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Normal bone remodeling depends of a balance between bone forming cells, osteoblasts and bone resorbing cells, the osteoclasts. In chronic arthritides and some inflammatory and autoimmune diseases such as rheumatoid arthritis, there is a great constellation of cytokines produced by pannus that impair bone formation and stimulate bone resorption by inducing osteoclast differentiation and inhibiting osteoblast maturation. Patients with chronic inflammation have multiple causes that lead to low bone mineral density, osteoporosis and a high risk of fracture including circulating cytokines, impaired mobility, chronic administration of glucocorticoids, low vitamin D levels and post-menopausal status in women, among others. Biologic agents and other therapeutic measures to reach prompt remission might ameliorate these deleterious effects. In many cases, bone acting agents need to be added to conventional treatment to reduce the risk of fractures and to preserve articular integrity and independency for daily living activities. A limited number of studies related to fractures in chronic arthritides were published, and future investigation is needed to determine the risk of fractures and the protective effects of different treatments to reduce this risk.

This paper discusses the design of automated lines, taking into account the use of industrial robots to perform technological operations. When planning manufacturing processes, as well as the placement of process equipment and robots in the production area, optimization techniques are usually used to ensure critical performance and efficiency indicators. The considered design methods are shown on the example of an automated line for the production of lithium-ion batteries. To design this line, 3D CAD models of technological equipment and transport lines were built. Based on the results of time analysis, those technological operations were opted, for which it would be advisable to use robots. The design of the robotic production for the technological operations was carried out using ABB robots. The robots required were chosen from the ABB catalog by weight, size of work area, speed and power. The plan of the robotic zones was drawn up using the ABB RobotStudio software, which allows visualizing the movements and programming robots off-line.