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The goal of the study was to investigate the concentration of 16 US EPA polycyclic aromatic hydrocarbons (PAHs) and check the sensory properties in 11 dry-cured meat products, smoked in three different ways (atmospheric simulation chamber (ATMOS), industrial chamber and traditional craft smokehouse) in one meat industry facility in Serbia. Controlled industrial production cannot provide all distinguishable and specific sensory properties of traditional dry-cured products, so more and more frequently meat industries decide to include the products smoked in traditional craft smokehouses in their product assortment. 16 US EPA PAHs were determined using a gas chromatography-mass spectrometry method (GC-MS). The obtained results are part of the production technology validating process of the tested smoked meat products. Total concentrations of benzo(a)pyrene, benzo(a)anthracene, benzo(b)fluranthene and chrysene (comprising the so-called "PAH4" group) in traditional homemade smoked bacon produced in compliance with all the guidelines of good manufacturing and hygiene practice, reached 15.82 µg/kg what was above the legal limits set by Serbian legislation. This indicates that there is a need for monitoring the PAH content compounds in traditional smoked meat products, and quite likely the revision of the current rulebook on traditional dry-cured meat products following the EU practice.

This paper investigates the experiences and opinions of students who learnt English for specific purposes via Moodle in the period between March and June 2020. The aim was to analyse the extent and forms of their engagement in this type of learning, explore their perceived positive and negative aspects of the course, and obtain suggestions for integration of this educational platform into English language classes in future. In addition, the paper aimed to investigate if there were any statistically significant differences related to the respondents' use of the platform and their participation in the course according to the level of their English language knowledge and digital competences. The sample comprised 107 students who completed an anonymous questionnaire. Quantitative and qualitative data were analysed using the descriptive statistics and content analysis. Kruskal-Wallis test was employed to detect the correlation between dependent and independent variables. The obtained results showed general satisfaction with the English language course run on Moodle, but also revealed the students' observation that the platform should accompany face to face classes in order to make learning more effective. The positive and negative aspects of the course identified by respondents were mostly in line with the existing research within the field of emergency remote teaching. Students pointed to the advantages of learning English via Moodle in terms of flexibility, accessibility of teaching materials, functions of tools such as tests, glossaries, forums. They also highlighted drawbacks, such as absence of real-time communication, work overload, and lack of self-discipline. It was interesting to discover that although research participants recognized the benefits of communication and collaboration tools, they did not engage with them to the anticipated extent. The fact that the mentioned issue has been identified in online learning in general suggests that the cause might lie in traditional, teacher-centred approach to teaching, which is still widespread in the educational system in Serbia. The obtained data carry important pedagogical implications for both learners and teachers in terms of incorporating digital tools in classes and devising a strategy for implementation of remote teaching in times of crisis. Students should be acquainted more thoroughly with virtual educational environment, which would, in turn, lead to the increased engagement and development of learner autonomy. In order to achieve this goal, teachers should strive to enhance their technological and pedagogic competences. This would also help them keep pace with technological educational innovations and encounter potential future educational emergencies better prepared.

Tumors of the thyroid gland, due to their localization in the neck, can as they grow pose a threat to the airway. Thyroid malignancies, aside from compression, can also infiltrate local tissue. The case presented is that of a female patient with advanced thyroid cancer that required urgent airway management, but due to the propagation of the malignancy into the mediastinum and consequent compression of distal trachea and lung tissue, the hospitalization ended with a fatal outcome regardless of the treatment undertaken. Even advanced airway management methods (endotracheal intubation or tracheotomy) are sometimes not enough to save our patients' lives.

The goal of learning in physical and health education (PHE) is for the student to improve physical abilities, motor skills and knowledge in physical and health culture, in order to preserve health and apply proper and regular physical exercise in modern living conditions and work. On the basis of the goal of the PHE teaching, the biological, pedagogical, and educational tasks are determined, the realization of which leads to the outcome of the PHE teaching. The biological tasks of physical education imply that a positive influence on students' proper growth and development is possible if the teacher is familiar with the structure and functions of the most important organic systems, the biological laws of development, and the impact of physical exercises on the organism. Pedagogical tasks include educational and learning tasks that intertwine and complement each other. Learning tasks should primarily contribute to the acquisition of motor skills and habits (sports-technical education), but also to the theoretical knowledge aiming to understanding the purpose of exercise, structure, method, and performance of certain exercises. Educational tasks, the teaching content, methods and forms of teaching are planned in accordance with their educational potential so that during the PHE classes, the students acquire the qualities and values contained in the PHE syllabus and at the same time represent universal human qualities and values that contribute to the development of the student's complete personality which is the ultimate ideal to strive for in education. By achieving the goals of the PHE syllabus, students acquire knowledge, skills, attitudes, and values about exercise (basic terms about exercise, how to perform an exercise and what a specific exercise is for), physical education, sports, recreation, and health. Specially planned and designed information about exercise and health is delivered immediately before, during, and after exercise in class. The goal, tasks, and outcomes of the course are achieved through the teaching of physical and health education (2 school hours per week) and compulsory physical activities for each student (1.5 school hours per week). This research is focused on the most frequent disruptive factors that lower the efficacy of implementation of PHE teaching in the higher grades of elementary school. The research was based on the general assumption that the teaching of physical and health education significantly contributes to the growth, development, health, upbringing, and education of students, but that it is not implemented as effectively as it could be. In contrast to many previous studies in which answers were collected from teachers or parents, in this research the answers were collected from the students in the higher grades of primary school themselves, since they are direct participants in the PHE classes and their development, education, and learning in PHE classes is the main outcome of teaching (Parkes et al, 2022; Amamou et al, 2021; Holden et al, 2020). It was interesting to analyse from the students' point of view what the most frequent disturbing factors are and whether some of the criterion variables affect it, such as the class the students attend; grade in physical education in the previous semester; and the general success of students in the previous semester. The research was conducted in January 2023 on a sample of 101 students at the Kirilo Savić Elementary School in Ivanjica. The data collected by the Scale - EE-MCDF-RPHET (a = 0,602) were processed by factor analysis, analysis of variance, and the Mann-Whitney U test. Factor analysis identified five factors that indicate educational efficiency and the most disruptive factors of PHE teaching. They are: 1) inconsistent practicing of different sports contrary to the student's assessment of the educational efficiency of the PHE teaching; 2) effectiveness of teaching; 3) the importance of active sports training; 4) football training contrary to the student's assessment of the educational efficiency of the PHE teaching; and 5) student safety. The analysis of variance showed that such assessments of students are not significantly influenced by the class they attend, success in physical and health education and education and general success in the previous semester, while the Mann-Whitney U test determined that such assessments of students are significantly influenced by actively playing a sport. Based on the results of the research, a proposal was made for an innovative approach to the implementation of physical and health education teaching in elementary schools, according to innovative teaching systems and innovative didactic-methodical teaching models. Teaching according to these models is planned, implemented, and evaluated in a multi-step and reverse design. In such a class, students are more involved in practicing, active learning, and participating in PHE classes. Based on the desired outcomes of the PHE classes, the goal is for as many students as possible, preferably all, to get involved in the work of sport clubs and in the future take up sports. In this way, the knowledge, skills, habits, and abilities the students develop in PHE classes and in sports clubs will be of fundamental importance for students outside the classroom and serve them in their daily activities in various situations in the family, school, local environment and wider social community. In order to achieve this, it is necessary to constantly strengthen the competences of teachers for planning, implementation, and evaluation of PHE teaching.

In metallurgical processes, metal sheet cutting is usually a basic technological operation that needs to be performed. All other technological operations follow the procedure of metal sheet cutting, with the final aim of manufacturing a final product. Machines used for that basic metal cutting operation shall be reliable, efficient, fast, and relatively easy to work with. While working with a laser, the authors noticed the inefficiency of cutting with nitrogen. Nitrogen bottles got empty too quickly, which caused additional costs. Inefficient, i.e., excessive nitrogen consumption requires a more frequent supply of nitrogen. During the COVID-19 pandemic, nitrogen was not always available, as suppliers shifted to manufacture oxygen bottles for medical needs. Therefore, the authors engaged in finding solutions to reduce the consumption of nitrogen at cutting. The mentioned problem was studied within the experiment that focused on the optimization of nitrogen use during fiber laser cutting, the procedure, and results of which are described in this paper. Specimens of different cutting parameters were prepared and cut to measure their roughness and burr height. The collected data were used to create a mathematical model with an ANOVA table. The experiment resulted in the determination of optimal cutting parameters achieved by the lowest possible cutting gas pressure.

Introduction/Objective. Revascularization in multivessel coronary artery disease (MVD) in patients with ST elevation myocardial infarction (STEMI) is a matter of debate. We sought to compare outcomes between revascularization strategies based on angiographic lesion severity or inducible ischemia. Methods. In prospective study, first ever STEMI patients with MVD, defined as > 70% stenosis in non-culprit vessel, treated with culprit only primary PCI were randomized to: A. Complete revascularization of all nonculprit significant lesions during initial hospitalization; B. Complete revascularization after 30 days, or C. Revascularization based on non-invasive testing for inducible ischemia. The study explored occurrence of major adverse cardio-cerebral events (MACCE) (cardiac death, repeated MI, cerebrovascular event). Results. The study enrolled 120 patients with door to balloon time within appropriate limits (A 51 ± 26 vs. B 47 ± 33 vs. C 44 ± 29 min, p = 0.604) The patients in group A underwent complete revascularization at 6 [4–7] days after primary PCI, while in the group B it was 35 [32–39] days. In group C, 16/43 (37.2%) patients underwent PCI at 82 [66–147] days after infarction (p < 0.001). The patients were followed for 2.7 ± 0.8 years. The events occurred less frequently in patients that underwent planned complete revascularization compared to those who underwent ischemia testing (7.8 vs. 20.9%, p = 0.040). Kaplan–Meier analysis favored complete delayed revascularization (MACCE A 8.8 vs. B 6.9 vs. C 20.9%, log rank p = 0.041). Conclusions. Planned, angiography guided, complete revascularization after initial event may be favorable strategy compared to single stress test for MVD in STEMI.

The exchange of large amount of data contributed to making information technologies an integral part of the modern world, often shaping public opinion, whether through its using, or abusing. In such a sense, modern terrorism uses or abuses various possibilities of information technologies, especially Internet, for the promotion of its own activities, as well as for the recruitment. Internet usage made the eradiation of terrorism propaganda such an easy task, so Internet practically became overwhelmed by it. Attitudes and threats expressed by terrorists that put their opponents under serious pressure, as well as recruitment of new members has contributed to to an increase in the number of terrorist groups that abuse the Internet for media purposes. Additional problems stem from the impossibility of their effective and timely control in a bid to prevent abuse aimed at terrorist propaganda, but also from the fact that most propaganda activities can neither be prevented nor limited in time, since such preventions and limitations infringe human rights, such as freedom of expression, religion and others. Since propaganda itself is not prohibited, the use of propaganda for promotion, financing, recruitment, training and commission of terrorism purposes is characterized as a criminal offense. In accordance with the European legislation, in order to provide evidence of incitement to terrorism, the connection between intent and direct causality has to be specified between the alleged propaganda, actual conspiracy or commission of terrorist acts. In this regard, the aim of this paper is to point out to danger of terrorist propaganda on the Internet, as well as to its types of manifestations (symbols) in an attempt to identify it in a timely manner and to curtail it in an adequate way.

Background/Aim. Patients in a neurologic intensive care unit (ICU) are especially susceptible to healthcare-associated infections (HAIs). HAIs are cause of significant morbidity and mortality. Aim of this study was to assess the incidence of HAIs, to identify significant risk factors (RFs) and causative microorganisms for HAIs and to identify RFs for inhospital mortality in a neurological ICU. Methods. A prospective cohort study was conducted in the six-bed ICU of the Clinic for Neurology, Military Medical Academy in Belgrade from January 1, 2014 to December 31, 2016. Active surveillance on HAIs was performed by the hospital infection control team, using methodologies of the European Centre for Disease Prevention and Control and the National Healthcare Safety Network/Centres for Disease Prevention and Control. Results. One hundred forty eight patients with a total of 2,708 patient-days were enrolled. There were 49 HAIs in 39 patients during the study period. The incidence and incidence density of HAIs were 26.3% and 18.1 per 1000 patient-days, respectively. The most frequent HAIs were urinary tract infections (15.5%), pneumonia (10.1%) and bloodstream infections (4%). RFs independently associated with HAIs in the neurological ICU were: urinary catheter [risk ratio (RR): 5.6; 95% confidence interval (CI): 1.153–27.632], urinary catheter-days (RR: 1.1; 95% CI: 1.057–1.188), central-line days (RR: 1.1; 95% CI: 1.010– 1.150), and mechanical ventilation (RR: 0.3; 95% CI: 0.079– 0.859). The most common microorganism was Klebsiella spp. RFs independently associated with in-hospital mortality in the neurological ICU were: mechanical ventilation (RR: 6.5; 95% CI: 2.868–14.116), Glasgow Coma Score (RR: 2.7; 95% CI: 1.135–6,396), and age (RR: 1.03; 95% CI: 1.005– 1.055). Conclusion. Usage of invasive procedures during ICU hospitalization carries significant risk for development of HAIs. HAIs in ICU setting are most often caused by Gram-negative bacteria with substantial antimicrobial resistance. These results stress the importance of infection prevention.

Diabetes is the most important non-infectious disease affecting 5% of the general population. Different plant and mushroom extracts with hypoglycemic and antioxidant properties have been used traditionally as antidiabetic herbal medicines. The aim of this study was to study the in vivo effect of extracts obtained from the edible mushroom, Lactarius deterrimus (Ld), and chestnut, Castanea sativa (Cs), on the alleviation of liver damage in streptozotocin (STZ)-induced diabetic rats. The extracts were applied, either alone or in combination, for four weeks, starting from the last day of STZ administration. Diabetic rats treated with the extracts exhibited reduced hyperglycemia and lower hepatic oxidative stress. Extract treatment decreased the level of O-linkage of N-acetylglucosamine modified superoxide dismutase, catalase and NF-κB. Masson trichrome staining showed a decrease in collagen fiber deposition in the liver. Immunoblot analysis revealed the activation of the prosurvival Akt kinase after extract application. The obtained results revealed that the hyperglycemiareducing and antioxidant effects of the Ld and Cs extracts suppressed cytotoxic signaling pathways, attenuating the negative effects of diabetes on the liver. The examined extracts are beneficial in the prevention of liver damage and could be considered for prediabetes and diabetes management after a definitive phytochemical description of extract constituents and subsequent evaluation in preclinical and clinical studies. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 451-03-68/2020-14/200007]

Oxidative stress is one of the major mechanisms that underlies the damage of pancreatic β-cells and defects in insulin secretion in diabetes. As herbal preparations can alleviate oxidative stress through their redox-active secondary metabolites, in this study we investigated the cytoprotective effects of Centaurium erythraea extract (CEe) against H2O2- and SNP-induced oxidative/nitrosative stress in Rin-5F β-cells. The antioxidant activity of CEe and its effect on cell survival and insulin expression/secretion were evaluated. The CEe increased cell viability and ameliorated the disturbance of redox homeostasis in H2O2- and SNP-treated cells by decreasing DNA damage, lipid peroxidation and protein S-glutathionylation. The CEe restored GSH homeostasis in H2O2-treated β-cells and attenuated the SNP-induced disturbance of the GSH/ GSSG ratio. The H2O2- and SNP-induced disruption of CAT, GPx, GR, MnSOD and CuZnSOD activities was adjusted by the CEe towards control values, as well as mRNA and protein levels of GPx, MnSOD and CAT. The CEe increased insulin expression/secretion particularly in H2O2-treated β-cells, which was in accordance with the more pronounced antioxidant effect of the CEe observed in H2O2-treated β-cells as compared to SNP-treated cells. These findings support the beneficial effect of the CEe in preventing or slowing down β-cell damage and dysfunction caused by oxidative/nitrosative stress during diabetes development. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 173020]

This paper presents research of the solid particle erosion of conventionally and duplex treated vanadium carbide (VC) coatings produced on the C45E steel substrate by the thermo-reactive diffusion (TRD) technique. The Response Surface Methodology (RSM) based on Central Composite Design (CCD) was used to evaluate the effect of moving speed and impact angle as input variables on the erosive wear mass loss as the response. It was established that moving speed of the samples and the impact angle of the abrasive particles are statistically significant factors, while their interaction does not have significant effect on the wear process. The mathematical model of the investigated wear process was derived as well.

Background/Aim. Hand impairment in systemic sclerosis (SSc) patients is the most frequent manifestation of this progressive disease and often cause problems in daily activities and working ability. The correlation of altered hand functions in patients with SSc and their impact on working ability is not fully explained. The objective of this study is to assess the impact of altered hand functions of patients with SSc on their working ability. Methods. We assessed 20 patients with SSc (17 females, 3 males), with mean age of 45.5 ± 11.9 years (min 29, max 69, Med 44.0 years). The movements of fingers, wrist and forearm were examined by measuring active range of motion of the hand and fingers, muscle strength of the fingers, the skin lesions by modified Rodnan score, the function of the fingers, hands and forearms by the Hand Mobility in Scleroderma (HAMIS) test, as well as the condition of the capillaries in the fingers by capillaroscopy and working capacity by Work Ability Index (WAI). Results. Reduced strength on at least one tested muscle, was established in all patients, thickening of the skin on the hands in 14/20 (70%) and the fingers in 19/20 (95%), “scleroderma type” capillary changes in 15/17 (85%), decreased range of motion in finger joints in 16/20 (80%) of the patients. Also, 14/20 (70%) of subjects reported problems at work [decrease performance achieved in 8/20 (40%), reduction of working hours in also 8/20 (40%), leaving out some of the work in 14/20 (70%), and investing of extra effort in 15/20 (75%)]. By means of WAI, work ability assessment questionnaire, it was found that the working capacity was reduced in 11/20 (55%) of our patients. None of the patients was in the group of the most serious cases, the “poor” category; in the “moderate” category there were 6/20 (30%), while 5/20 (25%) of the patients were in the group with minimally reduced working capacity (“good” category). There was a statistically significant correlation between the thickened skin on the fingers (p < 0.05), reduced muscle strength in the fingers (p < 0.002) and limited mobility of the individual finger joints (p < 0.05), with information on reduced working capacity obtained by means of WAI questionnaire and with answers to questions about problems at work. Conclusion. The thickened skin on the fingers, reduced fingers muscle strength and limited mobility of certain finger joints in patients with SSc cause decreasing working capacity for all jobs that include manual activities.

Background/Aim. Percutaneous coronary interventions (PCI) in bifurcation lesions having more than 50% stenosis of both the main branch (MB) and the side branch (SB) remain challenging. Measurements of the vessel diameters and angles using quantitative coronary angiography (QCA) software have been used in evaluating PCI outcomes. We investigated potential effects of provisional stenting of the MB on SB coronary blood flow by determining quantitative vessel parameters in “true” non-left main coronary bifurcation lesions using conventional two-dimensional QCA. Methods. The study was prospective and conducted in a highvolume university PCI center. Study included patients with “true” native coronary artery bifurcations (Medina 1.0.1; 0.1.1; 1.1.1) treated with “provisional” stenting of the MB. Patients were excluded from the study if having left ventricular ejection fraction of less than 30%, having renal failure with creatinine clearance below 30 mL/kg/m2 or bifurcation lesions within the culprit artery causing myocardial infarction, grafted surgically or previously treated by PCI. QCA analysis included measurements of reference vessel diameters (RVD), diameter stenosis (DS) and bifurcation angles. Results. The study included 70 patients with 72 “true” non-left main bifurcations. Most of the bifurcations were located in the left anterior descending (LAD) – diagonal (Dg) territory. Compromise of the SB ostium defined as thrombolysis in myocardial infarction (TIMI) < 3 coronary flow occurred in 17/72 (23.6%) bifurcations. It was treated by either balloon angioplasty only of the SB ostium (9/17, 52.9%) or stent implantation [8/17 (47.1%)]. In a logistic regression analysis, including previously recognized predictors of SB compromise (bifurcation’s angles, RVD, DS and ratio of MB RVD to stent diameter ratio), only MB RVD to stent diameter ratio after PCI remained independent predictor of SB coronary flow compromise after stent implantation in the MB [OR 2.758 (95% CI 1.298–5.862); p = 0.008]. Conclusions. It appears that SB decreased coronary blood flow after “provisional” stenting in “true” non-left main bifurcations is associated with greater MB to stent diameter ratio.

Phototrophic microorganisms can be found in biofilms at entrances to caves where they have access to sufficient sunlight, water and nutrients; however, they can also be found inside caves, where they are carried by animals and people, and can proliferate in the presence of artificial light. Although the genus Humidophila includes some well-known cosmopolitan species, further exploration of its rare, insufficiently investigated representatives in different geographical areas and unusual habitats is necessary. Caves remain unknown, little-explored habitats, and many species currently known to science were recorded for the first time. This study aimed to report species belonging to the genus Humidophila that were identified in 19 caves in Serbia. A total of ten species of this genus were recorded and some of them are documented for the first time in Serbia. The most abundant species were H. contenta (found in 16 caves), H. paracontenta, and H. aerophila (found in 13 caves), whereas H. pyrenaica was identified in only one cave. The rare species, H. brekkaensoides and H. vidalii, were also documented and described, but with different dimensions from those provided in current identification keys. [Projects of the Serbian Ministry of Education, Science and Technological Development, Grant no. 176018, Grant no. 176020, Grant no. 37009, and Project FP7 “Capacities” Program]

Contemporary culture is often characterized as the ''instant culture'', in which new mobile technologies and social nature of Web 2.0 enable individuals' continual access to seemingly unlimited scope of information and media content, no matter where they are. This creates a channel through which these individuals become constantly available for interaction, therefore by creating digital content it is now possible to engage them, in such a way that this interaction will not disturb their everyday habits and behavior in using digital media. That is where content marketing is created: a tool which strives to engage individuals through media content that will create a certain value for the consumer. Since content marketing demands quality and creative content that also has certain marketing purpose, here arises the question of the integrity of such creative process. Marketing activity, journalism, and creativity must be driven by certain ethical codes, which will insure the truthfulness, honesty, and safety of the interaction between the consumers and the creators of media content. This paper strives to divulge ethical ambiguities in content marketing, emphasizing truthfulness and transparency as key factors of its success as a tool in digital marketing, while also accentuating the importance of creating valuable and quality content for further evolution of this variety of expression through digital media.

Introduction. Since clinical and electrocardiographic features of various cardiac disorders may overlap, the differential diagnosis of left ventricular (LV) dysfunction may be difficult even for the most experienced physicians. Recent advances in cardiac imaging may help clinicians to establish an accurate diagnosis and initiate adequate treatment. The aim of this case report is to raise awareness of a very short-lasting LV dysfunction during respiratory infections and to underline the importance of multimodality imaging in this clinical setting. Case outline. A previously healthy 37-year-old male presented with atypical chest pain and ST-segment elevation in the inferolateral leads during severe mental stress and acute respiratory infection. Acute myocardial infarction, myocarditis, coronary vasospasm and stress cardiomyopathy were all considered as a differential diagnosis. A rapid onset of severe LV dysfunction and a complete recovery within 4 days was detected by echocardiography and further evaluated by multimodality imaging, including multislice computed tomography and cardiac magnetic resonance imaging. Conclusion. Severe, but very short-lasting LV dysfunction may be triggered by various causes, including upper respiratory tract infections. Since the symptoms of respiratory infections may obscure those of LV dysfunction, myocardial dysfunction in these patients may go undetected with possible serious consequences.

O plakatu kao sredstvu komunikacije Vrijeme u kojem živimo potpuno je usaglašeno sa novim medijima vizuelnih komunikacija u koje se nedvosmisleno ubraja i plakat, sa svojom apsolutno prijemčivom i likovno pretpostavljenom formom, koja prati, osluškuje, provocira, uzbuđuje, obavještava i uvodi u kompleksan svijet likovnosti i dizajna. Brojni teoretičari, istoričari i umjetnici raznih profila su se bavili njegovom pojavom i analizom, te predlaganjem raznih mogućnosti definisanja samog pojma plakata i plakatske umjetnosti, pa najčešće nailazimo na informacije o plakatu kao umoženoj obavijesti koja se postavlja na javnim mjestima (moguće od riječi plak -mrljica ili krpica)? U engleskom jeziku se koristi termin poster (prihvaćeno i u našem jeziku kao doslovni prevod), ili posted up (objavljeno, u smislu postavljanja na javno mjesto). U francuskom jeziku se koristi the World Biennial of Student Poster -A Case Study Abstract: The paper World Biennial of Student Poster -A Case Study aims to show the complex structure of the poster as an art form in a historico-analytical and content-wise manner. Viewing the poster in the light of the progressive technological and innovative possibilities of modern information technologies, constantly requires challenging of the scopes and justification of the existence of a "classic" poster. Its role in contemporary society has been analyzed through various forms of manifestation in the spheres of art and modern design. Insufficiently paid attention to the essence of artistic expression through the poster, which has historically been marginalized in relation to classical painting, has positively changed over time, and through the apostrofing of the strength and the range the poster reaches, it has pointed to the significant changes in the society that this type of communication has achieved. In this paper, a prominent event of the Academy of Arts in Novi Sad, the World Biennial of Student Poster, was selected for the case study, and through the analysis of eight exhibitions of the Biennial, its role since 2004 has been evaluated with an obvious improvement in pedagogical and creative work on the poster.

Background/Aim. Despite the modern ways of treating diabetes mellitus (DM), a half of the patients do not achieve the optimal metabolic control, which increases a risk of complications and occurrence of emotional “burnout” of patients. The goal of the research was to determine the level of emotional distress of patients with diabetes, and the association of the level of emotional distress with sociodemographic traits and the disease characteristics. Methods. The research was conducted from 01.01.2016. to 04.30.2016. in the Comunity Health Center in Banja Luka. The research was conducted in a group of 113 randomly selected patients (63 men, 50 women) with diabetes, with an average age of 63.93 years. A majority of respondents have type 2 DM (91.12%). The Problem Areas in Diabetes Questionniare (PAID) was used in the research. Another questionnaire used contained questions related to sociodemographic traits (sex, age, education), and disease traits (type of DM, duration of the illness, types of therapy that the patient uses in the treatment of DM, the value of hemoglobin A1c (HbA1c) over the last three months, the presence of microvascular complications). Results. According to the total score of the PAID questionnaire, 64 (56.6%) respondents had a moderate level of emotional distress. The level of emotional distress is higher in the group with a higher HbA1c values, but without a statistically significant difference compared to the group with the achieved goal HbA1c values. Two-thirds of respondents with microvascular complications manifest a moderate level of distress. The association between occurrence of distress with the occurrence of microvascular complications was confirmed. Conclusion. More than a half of patients with DM have an elevated level of distress of a moderate degree, and two-thirds of patients with DM with the microvascular complications have an elevated level of distress of a moderate degree, which indicates the importance of interdisciplinary cooperation of endocrinologists, vascular surgeons and psychiatrists.

This paper addresses professional development of teachers who run Business English courses in vocational high schools in Serbia. The analysis of professional development programmes offered in Serbia indicated that Business English teachers' needs are not sufficiently met. Therefore, by investigating teachers' attitudes, experience, and needs with regard to professional development, it is possible to gain valuable guidelines which might help improve the overall situation. The research, which was of both quantitative and qualitative nature, was conducted with 31 respondents who were asked to complete the questionnaire which centered on the topics such as frequency of attending professional development (PD) programmes, criteria for selecting them, types of PD activities that teachers undertake, attitudes towards features of PD programmes such as quality, relevance, applicability, etc., teachers' needs in terms of strengthening various professional competences (e.g. field competences, curricular competences, ICT competences, etc.), ways of improving professional development programmes and the like. The teachers' responses confirmed that the current situation regarding professional development in Serbia is unfavourable, but also reflected their understanding and awareness of the importance of this process for building their professional identity and improving their pedagogical practices. The respondents expressed a high level of need for developing both general and specific teaching competences. They also highlighted the importance of being provided with contemporary, relevant and applicable programmes which are delivered by educators who are well acquainted with both pedagogical theory and teachers' working environment. Taking into account teachers' needs while choosing the location and determining the time of PD activities could additionally increase PD attendance. Another factor that could improve the overall situation regarding professional development is the greater presence of virtual PD programmes.

Previously, we described the link between C-X-C motif chemokine 12 (Cxcl12) gene induction and DNA hypomethylation in the absence of poly(ADP-ribose) polymerase 1 (PARP-1). We have now firmly established that demethylation is the primary cause of gene induction on the basis of Cxcl12 gene upregulation upon treatment with the demethylating agent 5-azacytidine (5-aza). Since the demethylation state of Cxcl12 is favored by PARP-1 absence, we investigated the presence of ten-eleven translocation (TET) proteins on the Cxcl12 promoter in order to corroborate the relationship between the demethylation process and increased gene expression that occurs in the absence of PARP-1. Analysis was performed on the promoter region within CpG islands of Cxcl12 from control mouse embryonic fibroblasts (NIH3T3) and PARP-1 knock-out mouse embryonic fibroblasts (PARP1-/-). The lack of PARP-1 increased the abundance of TET2 on the Cxcl12 promoter, suggesting that TET-mediated demethylation provoked by the absence of PARP-1 could account for the observed increased expression of this chemokine. Deciphering the regulation of DNA (de)methylation factors that control Cxcl12 expression may provide an additional therapeutic approach in pharmacological interventions where gene switching on or off based on targeted stimulation or inhibition is necessary. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 173020]

Commercial feed intended for dogs and cats is an almost unrecognised source of human infection with various serovars of Salmonella enterica. However, people may catch the infection both via direct contact with contaminated pet feed and by contact with pets, which usually shed Salmonella without signs of infection. A relatively new trend of feeding dogs and cats with raw feed is considered to be a special risk owing to the fact that it usually contains foodborne pathogens, such as Salmonella spp., Escherichia coli and Campylobacter spp. Nonetheless, the epidemiological data do not support this idea. In the current review relevant data on the significance of pet feed in the outbreak of human salmonellosis are discussed and the recommendations for the prevention of the infection originating from these sources are suggested.

The results of the research into the microbiological contamination of litter used by broiler chickens are presented. Litter samples were taken prior to the introduction of chicks (day 0) and in 7-day intervals until the end of the fattening period. The total numbers of aerobic mesophilic microorganisms, yeasts, moulds and Clostridium perfringens spores, and the presence of bacteria of the Salmonella genus were determined. The total microbial count in newly laid litter was 7 log10 CFU/g, which increased to 9 log10 CFU/g by the 4th week. However, at the end of the 5th week, it was at the same level as in newly laid litter. C. perfringens spores, presumably originating from chicks' faeces, were first detected on day 7. In the next 7 days their number increased, reaching 3-4 log10 CFU/g, and remained at approximately same levels until the end of the research. The initial mould contamination was 5-6 log10 CFU/g. However, from day 21 moulds were not isolated, but only yeasts of the Saccharomyces genus. It is supposed that these were deposited with chicks' faeces, due to their presence in complete broiler feed. No bacteria of the Salmonella genus were ever isolated from the litter. In conclusion, the total numbers of microorganisms in deep litter reach their peak in approximately a month, which is followed by their decrease. Deep litter is a favourable environment for probiotic yeast cultures. Added to feed intended for broilers, they can positively influence the microbial composition of litter, providing healthier environment to fattening broilers.

The aims were: evaluation of the correlation between the Dental Aesthetic Index (DAI) and Index of Complexity, Outcome and Need (ICON); the assessment of orthodontic treatment need for schoolchildren in a population with two indices, separately for schoolchildren with mixed and permanent dentition; the estimation of the population share that could not receive orthodontic treatment because of the presence of caries and/or gingivitis.

We examined whether CXCL12α improves insulin secretion by influencing the Ca2+ oscillation pattern and Ca2+ influx ([Ca2+]i), thereby enhancing the viability of pancreatic islet cells in oxidative stress. The islets of Langerhans were isolated from male OF1 mice and pretreated with 40 ng/mL of CXCL12α prior to exposure to 7.5 μM hydrogen peroxide, which served to induce oxidative stress. Incubation of islets with CXCL12α induced pancreatic β-cell proliferation and improved the ability of β-cells to withstand oxidative stress. Consecutive treatments of isolated islets with hydrogen peroxide caused a decline in β-cell functioning over time, while the CXCL12α pretreatment of islets exhibited a physiological response to high glucose that was comparable to control islets. The attenuated response of islets to a high D-glucose challenge was observed as a partial to complete abolishment of [Ca2+]i. Treatments with increasing concentrations of CXCL12α decreased the number of Ca2+ oscillations that lasted longer, thus pointing to an overall increase in [Ca2+]i, which was followed by increased insulin secretion. In addition, treatment of islets with CXCL12α enhanced the transcription rate for insulin and the CXCR4 gene, pointing to the importance of CXCL12/CXCR4 signaling in the regulation of Ca2+ intake and insulin secretion in pancreatic islet cells. We propose that a potential treatment with CXCL12α could help to remove preexisting glucotoxicity and associated temporary β-cell stunning that might be present at the time of diabetes diagnosis in vivo. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 173020]

This review summarizes the effects of α-lipoic acid (LA) on liver damage and complications in diabetes and drug toxicity. LA is a naturally occurring dithiol compound that plays an essential role in mitochondrial metabolism in its protein-bound form. In contrast, free LA in supplements has diverse biological actions, and its antioxidant effect is its most studied and important activity. Due to its strong antioxidant potential, LA could have a promising role in the treatment of pathologies resulting from an imbalance in redox homeostasis. This includes diabetes, which produces deleterious effects on many organs, including the liver. In diabetes specifically, LA prevents β-cell destruction, enhances glucose uptake, and its antioxidant effects may be particularly useful in slowing down the development of diabetic complications. Diabetesrelated liver damage is a serious complication in which oxidative stress is the main contributor to tissue injury. Oxidative stress is regarded as one of the main pathological mechanisms underlying liver pathologies provoked by other insults, such as drug toxicity, where LA could also be a useful agent in therapeutic intervention. However, before wider application of LA in a clinical setting, experimental and clinical research needs to be extended. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 173020]

The technology and economy are constantly changing by their nature, and because of that, there is some pressure on educational institutions to change their structure and functional characteristics. Parallel to global development, especially in the last quarter of a century, there has been an evident change related to the presentation of educational programs, educational technology, learning and teaching, as well as roles in the educational process typically performed by teachers and students. Schools must create a more efficient educational environment, which will take into account the educational needs, generate the knowledge, skills, attitudes, and develop an organizational strategy that will ensure the development of individuals and the sustainability of social life, which will prepare individuals for the inevitable change. Therefore, the paper deals with the problems of resistance to changes in higher education through a theoretical analysis of the problem, while also examining ways for overcoming resistance through concrete actions. The willingness and ability of employees to be actively and appropriately involved in the process of change is one of the key elements that affects the efficiency, profitability, reputation and survival of any organization.

This paper looks at the professional development of Business English teachers at institutions of higher education in Serbia. The current situation regarding the possibilities for improving these teachers' competencies is unsatisfactory, and in view of this, the study sought to analyze their attitudes and needs in order to suggest guidelines for creating an adequate model of professional development. The sample comprised 30 teachers, and a questionnaire was used as a research instrument. The results indicate that teachers' attitudes coincide with contemporary trends in the area of professional development, at the same time highlighting deficiencies in the current system of professional development in Serbia. A new model of professional development should make it possible for teachers to improve their general and professional competencies as identified through needs analysis; it should be based on collaboration not only between teachers but between all actors in education, should include mechanisms of monitoring the application of new knowledge, and make more extensive use of virtual forms of development. The value of the paper is in its potential for practical application, since it provides crucial information for creating a relevant and effective model of professional development for Business English teachers. The paper can also be used as a starting point for further research in the area of professional development of teachers of foreign languages for specific purposes more generally.

Introduction: Although large multiple myomas are a well-known cause of infertility, it is not uncommon to encounter pregnancy with such myomas. Management of women with large multiple myomas is controversial, both during pregnancy and delivery. Such myomas can also cause significant morbidity during the puerperium. Caesarean section is the most common way of delivery. Case report: A patient with large multiple myomas underwent a cesarean myomectomy with intraoperative cell salvage at 36 weeks of gestation. Both fetal and maternal outcomes were favorable. The lower uterine segment was accessible, despite the presence of myomas, and a live fetus weighing 2600 g was delivered without difficulties. Following a hysterotomy suturing, the largest myoma (210 × 180 × 155 mm) was removed and the myoma bed was sutured in two layers. Cell-saver was introduced during myomectomy saving significant amount of blood. Careful inspection confirmed appropriate hemostasis, so it was decided to remove the remaining eight myomas, and this was done without breaching the uterine cavity. Conclusion: There are few literature reports on intraoperative cell salvage as a technique of handling intraoperative hemorrhage during a CM. As documented by our case, the use of intraoperative cell salvage represents a significant advantage in such cases when combined with extensive surgical experience in conventional myomectomy.

Diatoms are a widespread group of organisms with well-known ecological preferences. Knowledge of their diversity is of great importance for assessing the environmental status of different aquatic ecosystems. The present study was based on 55 different localities that included rivers, streams, channels, accumulations and salt marshes throughout Serbia. The results of this study expanded the diatom checklist by 80 taxa, including two new recorded genera (Fistulifera and Microfissurata) for Serbia. The data were obtained by combining light microscopy (LM) and scanning electron microscopy (SEM) that provided reliable identification, which is very important in diatom diversity studies. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. TR 037009]

Introduction: Breast milk is the optimal source of nourishment for babies up until the age of 6 months. Promotion of breastfeeding reflects public health policies, however an insufficient number of expectant mothers are aware of official the recommendations and the significance of breastfeeding. Socio-demographic characteristics of expectant mothers such as age, education and income, can modify attitudes towards breastfeeding. Positive attitudes of expectant mothers towards starting and continuing to breastfeed are an important component of proper child growth and development. Goal: The main goal of this study was to assess the knowledge and attitudes of expectant mothers about breastfeeding, and establishing if there is a difference in attitudes of expectant mothers in relation to their socio-demographic characteristics. Material and methods: Research was conducted as a cross section study by conducting a survey of 107 expectant mothers that have attended the School for expectant mothers at the community health centre in Novi Sad. The survey consisted of socio-demographic questions and the Iowa Infant Feeding Attitude Scale, IFFAS. Data processing included methods of descriptive and inferential statistics. Program pack SPSS (version 21) was used. Values of p

The health safety of honey includes the correctness in terms of the presence of different contaminants, which also implies the antibiotic residue. The presence of antibiotics in honey is prohibited, and methods of food analysis are prescribed in order to reliably determine antibiotics in food. In this paper the application of ELISA tests for determination of selected antibiotics and sulfonamides in honey is shown. The possibility of using four ELISA tests for the analysis of tetracyclines, streptomycines, chloramphenicol and sulfonamides was examined. Each test was evaluated after application on honey samples spiked with standard solution of a particular analyte. Samples were prepared according to the instructions of the ELISA test manufacturer referring to honey. Results of investigation of all ELISA tests, except for sulphonamides, have shown satisfactory accuracy (73-111%) and precision (14-16%). Recovery for sulfametoxypyridazin was low (40%), and for low tetracycline concentration was somewhat higher than acceptable (139%). The detection limits were in accordance with the limits given by the ELISA kit manufacturer and are also satisfactory in relation to the requirements of the legislation (0.075-3 μg/kg). The test kits can be used to screen the presence of tetracycline, chloramphenicol and streptomycin in the honey, taking into account the obtained validation parameters.

Endometriosis is characterized by endometrial tissue found outside of the uterus (primarily in the pelvic cavity), causing chronic inflammatory reaction, infertility, and pain. The impact of endometriosis on different aspects of women’s life is important, including family and social life, work, and reproduction. The usual way of examining endometriosis is history taking, recognition of typical symptoms, clinical examination, and the use of imaging techniques, but the diagnosis is made by histopathology findings, usually after laparoscopy. The aim is to represent current recommendations and guidelines referring to endometriosis diagnostics and therapy, proposed by two major societies dealing with reproductive medicine: European Society for Human Reproduction and Embryology (ESHRE) and American Society of Reproductive Medicine (ASRM). The recommendations refer primarily to the therapeutic modalities in infertility and pain problems caused by endometriosis, and represent the basis of appropriate strategy for overcoming numerous problems linked with this chronic illness.

In the recent years, extensive studies have been conducted on the application of bioremediation in order to prevent and solve the global problem of nitrate accumulation especially in water and soil. In the studies related to the biological denitrification, Pseduomonas stutzeri is usually used as a model microorganism due to its ability of performing a complete reduction of nitrate. The aim of this work is to establish a culture medium at a laboratory level for maximizing the biomass production of Pseduomonas stutzeri ATCC 17588 and Pseudomonas stutzeri D1, previously isolated from the Danube (Novi Sad, Serbia) by using a Box-Bhenken experimental design and response surface methodology. The selected independent variables (+, 0, - levels) were: glucose (0, 1 and 2 g/L), KNO3 (1, 2 and 3 g/L), and peptone (0.4, 2 and 4 g/L), while the number of viable cells (log/mL) was chosen as a dependent factor (response). Based on the obtained results, it can be noticed that the maximum number of P. stutzeri ATCC 17588 viable cells is achieved when the initial content of glucose, KNO3 and peptone in the medium are 0 g/L, 2 g/L and 4 g/L, respectively. In the case of P. stutzeri D1, the most appropriate media for enhancing the biomass production consists of glucose (1 g/L), KNO3 (3 g/L) and peptone (4 g/L). Тhe obtained results can be used for further technoeconomic analysis and scale up of the P. stutzeri biomass production. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. III45008]

Design of user-friendly and at the same time powerful robot programming methods is the subject of significant efforts undertaken by the international robotics community. For the purpose of facilitating robot programming, with regard to the most common present-day applications in industry, it would be useful to develop programming procedures for frequently used manipulator tasks which could be easily implemented and used as ready-made application software. Important class of industrial robot applications involves end-effector trajectories in planar surfaces. Development of robot programming language procedure intended for determination of object plane normal with respect to frame of interest, as well as programming of end-effector orientation is presented in this paper. This procedure can be used as integral part of task oriented robot programing applications as well as a procedure for explicit programming languages, and it is illustrated in practical example with the robot Lola 15.

This paper summarizes the programs intended for simulation of traffic processes in different telecommunications systems. These programs are developed, implemented and verified by the members of the Institute IRITEL through numerous scientific papers and doctoral dissertations taken during 50 years of the Institute activities. Two main areas of traffic simulations are related (but not limited) to the analyses of switching systems and mobile telephony systems.

Background: Our aim was to study the effect of GnRH agonist and antagonist protocols of ovarian stimulation on oxidative stress parameters in serum and the influence of oxidative stress parameters change on the outcome of IVF cycles. Methods: This prospective study included 82 patients who underwent IVF procedures. We determined SOD, MDA and SH groups in serum. Serum samples were obtained between the second and fourth day of the cycle and on the day of HCG administration during ovarian stimulation. Results: Patients were divided into two groups depending on the protocol of stimulation. The mean total and mature oocytes number and number of fertilized oocytes were higher in GnRH agonist group. There was no significant difference in biochemical pregnancy, miscarriage and live -birth rate in both groups. Mean serum SOD was significantly lower, while mean serum MDA and SH groups were significantly higher after ovarian stimulation. Delivery rate was higher in patients without OS while miscarriage rate was higher in patients with OS. Conclusions: Our study confirmed that there is a difference in the concentration of oxidative stress parameters before and after ovarian stimulation. IVF outcome is better in patients without OS after ovarian stimulation. However, the protocol of ovarian stimulation is neither associated with a change in oxidative stress parameters nor with the outcome of ART procedures.

This paper investigates the use of weasel claims in advertisements in English and Serbian. Weasel claims represent a form of covert communication and are characterized by the use of deliberately vague and misleading language. In the advertising discourse, this linguistic device helps advertisers to deal with sensitive issues, overcome consumers' distrust and thus influence their behavior. The research has been conducted on a corpus of 100 advertisements that belong to various categories, such as cars, cleaning products, cosmetics, drinks, food, etc., published in printed magazines and online sources from the year 2000 onwards. The aim of the analysis is to identify manifestations of weasel claims in the corpus, establish similarities and differences regarding their use in the given languages, and show how they influence the interpretation of the advertising message and create consumer behavioral patterns. Descriptive and contrastive analyses have been employed in the research. The study also draws on Grice's Cooperative Principle. The results will show that this deceptive tool is widespread in both languages and that its use in the advertising discourse in Serbian requires further research.

Introduction. Data on effects of thrombus aspiration on left ventricular diastolic function in ST-elevation myocardial infarction (STEMI) population are scarce. Objective. We sought to compare echocardiographic indices of the diastolic function and outcomes in STEMI patients treated with and without manual thrombus aspiration, in an academic, high-volume percutaneous coronary intervention (PCI) center. Methods. A total of 433 consecutive patients who underwent primary PCI in 2011-2012 were enrolled in the study. Patients were not eligible for the study if they already suffered a myocardial infarction, had been previously revascularized, received thrombolytics, presented with cardiogenic shock, had significant valvular disease, atrial fibrillation or had previously implanted pacemaker. Comprehensive echocardiogram was performed within 48 hours. During follow-up patients’ status was assessed by an office visit or telephone interview. Results. Patients treated with thrombus aspiration (TA+, n=216) had similar baseline characteristics as those without thrombus aspiration (TA-, n=217). Groups had similar total ischemic time (319 ± 276 vs. 333±372 min; p=0.665), but TA+ group had higher maximum values of troponin I (39.5 ± 30.5 vs. 27.6 ± 26.9 ng/ml; p15, as a marker of severe diastolic dysfunction (TA+ 23.1% vs. TA- 15.2%; p=0.050). During average follow-up of 14Ѓ}5 months, major adverse cardiac/ cerebral events occurred at the similar rate (log rank p=0.867). Conclusion. Thrombus aspiration is associated with a greater incidence of severe diastolic dysfunction in unselected STEMI patients treated with primary PCI, but it doesn’t influence the incidence of major adverse cardiovascular events. [Projekat Ministarstva nauke Republike Srbije, br. 175099]

Introduction. The role of tumor necrosis factor-α (TNFα) is well documented in pathogenesis of chronic periodontitis (CP) and type 2 diabetes (T2D). Considering short half-life of TNFα, tumor necrosis factor receptor-2 (TNFR2) is used as prosperous surrogate marker of TNFα activity. Objective. The aim was to detect TNFR2 serum concentration and correlate it with periodontal destruction in patients with diagnosed T2D and nondiabetics. Methods. The study included 85 patients divided into three groups: T2D + CP (group T2D, n = 34); nondiabetics + CP (Group PD, n = 27); and healthy controls (group HC, n = 24). T2D was diagnosed according to WHO criteria (2013) and periodontitis was diagnosed using International Workshop for a Classification of Periodontal Diseases and Conditions criteria (1999). TNFR2 level was measured by enzyme-linked immunosorbent assay (ELISA). Results. There was no difference in TNFR2 level among the groups (Kruskal-Wallis, p = 0.482). Significant correlation (Pearson’s correlation coefficient) was observed between clinical attachment loss (CAL) and TNFR2 concentration in PD group (rp = -0.460, p = 0.016). In T2D group, correlations were observed between TNFR2 concentration and CAL (rp = 0.363, p = 0.005) and periodontal inflamed surface area (PISA) (rp = 0.345, p = 0.046) and periodontal epithelial surface area (PESA) (rp = 0.578, p = 0.000). Conclusion. Higher concentration of TNFR2 was associated with higher CAL, PESA, and PISA scores in T2D group. Contrary to that, nondiabetics with higher values of CAL exhibited lower concentration of TNFR2, presenting potential protective effect on periodontal destruction. These results imply that diabetes may alter TNFR2 secretion originated from periodontium. [Projekat Ministarstva nauke Republike Srbije, br. 41008]

Introduction. Adherence to proposed lifestyle changes and prescribed medication in patients with stable coronary artery disease (SCAD) is poor. Objective. We sought to investigate the influence of adjusting guideline proposed medications on relief of angina in a large group of patients with SCAD in Serbia. Methods. The study included a total of 3,490 patients from 15 cardiology clinics with symptoms of stable angina and at least one of the following criteria: abnormal electrocardiogram (ECG), history of myocardial infarction (MI), positive stress test, significant coronary artery disease on coronary angiogram or previous revascularization. All the patients underwent comprehensive evaluation at initial visit and after two months. The relief of angina was study end-point defined as any reduction in Canadian Cardiology Society (CCS) class, number of angina attacks per week and/or number of tablets of short-acting nitrates per week. Results. Most patients were included based on abnormal ECG (48.4%). At Visit 1, the average number of prescribed classes of medications to a single patient increased from 4.16 ± 1.29 to 4.63 ± 1.57 (p < 0.001). At the follow-up, the patients had significantly lower blood pressure (141 ± 19 / 85 ± 11 vs. 130 ± 12 / 80 ± 8 mmHg; p < 0.001) and most of them reported CCS class I (63.3%). The average weekly number of angina attacks was reduced from 2.82 ± 2.50 at Visit 1 to 1.72 0 ± 1.66 at Visit 2, as well as average weekly use of short-acting nitrates to treat these attacks (2.69 ± 2.53 to 1.74 ± 1.47 tablets; p < 0.001 for all). Conclusion. Adjustment of prescribed medications to guideline recommendations in a large Serbian patient population with prevalent risk factors led to significant relief of angina.

Background: The aim of this study was to investigate the role of peripheral blood markers as additional diagnostic tools to transvaginal ultrasound (TVU) findings in the diagnosis of endometriosis. Methods: This study included 40 patients undergoing laparoscopy for suspected endometriosis from January to December 2012. Preoperative levels of serum CA125, CA19-9, CEA and mRNA expression levels for survivin and VEGF were obtained. Real-time PCR was used to determine relative gene expression. A new diagnostic score was obtained by deploying the peripheral blood markers to the TVU findings. Statistical methods used were Chi-square, Fisher's, Student's t-test or the Mann - Whitney test. Results: There was a statistically significant difference in serum CA125, survivin and VEGF levels in patients with endometriosis and those without endometriosis (p