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Your search keyword '"Victor V. Zyev"' showing total 2 results
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2 results on '"Victor V. Zyev"'

1. Magnetic Composite Submicron Carriers with Structure-Dependent MRI Contrast

Author

Anastasiia A. Kozlova, Sergey V. German, Vsevolod S. Atkin, Victor V. Zyev, Maxwell A. Astle, Daniil N. Bratashov, Yulia I. Svenskaya, and Dmitry A. Gorin

Subjects
magnetically-guided drug delivery systems, magnetite nanoparticles, magnetic resonance imaging (mri), polymeric core–shells, magnetic submicron core–shells, drug delivery, Inorganic chemistry, QD146-197
Abstract

Magnetic contrast agents are widely used in magnetic resonance imaging in order to significantly change the signals from the regions of interest in comparison with the surrounding tissue. Despite a high variety of single-mode T1 or T2 contrast agents, there is a need for dual-mode contrast from the one agent. Here, we report on the synthesis of magnetic submicron carriers, containing Fe3O4 nanoparticles in their structure. We show the ability to control magnetic resonance contrast by changing not only the number of magnetite nanoparticles in one carrier or the concentration of magnetite in the suspension but also the structure of the core−shell itself. The obtained data open up the prospects for dual-mode T1/T2 magnetic contrast formation, as well as provides the basis for future investigations in this direction.

Published
2020
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2. In vitro and in vivo MRI visualization of nanocomposite biodegradable microcapsules with tunable contrast

Author

Victor V. Zyev, Marina V. Novoselova, Gleb B. Sukhorukov, Dmitry A. Gorin, Nikita A. Navolokin, Sergey V. German, Daniil N. Bratashov, Boris N. Khlebtsov, Alla B. Bucharskaya, Maria V. Lomova, Evgeniya A. Burilova, Anastasia A. Kozlova, Georgy S. Terentyuk, Rustem Amirov, and Galina N. Maslyakova

Subjects
Materials science, Nanocomposite, In vivo degradation, Depot, General Physics and Astronomy, Nanoparticle, Biocompatible Materials, Capsules, Nanotechnology, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, Magnetic Resonance Imaging, 01 natural sciences, Biodegradable polymer, In vitro, Nanocomposites, 0104 chemical sciences, Drug Delivery Systems, In vivo, Drug delivery, Physical and Theoretical Chemistry, Magnetite Nanoparticles, 0210 nano-technology, Biomedical engineering
Abstract

Microcapsules, made of biodegradable polymers, containing magnetite nanoparticles with tunable contrast in both the T1 and T2 MRI modes, were successfully prepared using a layer-by-layer approach. The MRI contrast of the microcapsules was shown to depend on the distance between magnetite nanoparticles in the polymeric layers, which is controlled by their concentration in the microcapsule shell. A fivefold increase in the average distance between the nanoparticles in the microcapsule shell led to a change in the intensity of the MR signal of 100% for both the T1 and T2 modes. Enzyme treatment of biodegradable shells resulted in a change of the microcapsules' MRI contrast. In vivo degradation of nanocomposite microcapsules concentrated in the liver after intravenous injection was demonstrated by MRI. This method can be used for the creation of a new generation of drug delivery systems, including drug depot, with combined navigation, visualization and remote activated release of bioactive substances in vivo.

Published
2016
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