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2. Integrating mental health and psychosocial support into economic inclusion programming for displaced families in Ecuador

Author

Moyano, Arianna, Vergara, Daniela, Mirti, Amaleah, Bonz, Annie G., Monar, Adriana, Astudillo, Efrén, Vaca, Sara, Cordova, Karen, Armijos, Andrea, Barroso, Adrian, Cherrez, Cesar, Cottle, Jennie, DuBois, Aimée, Capriles, Isabella Fernandez, Grandes, Jean Pierre, Irarrazaval, Matias, Jaramillo, Belen, Kane, Jeremy C., Martinez-Viciana, Carmen, Mascayano, Franco, Rodríguez, Yescárleth, Schojan, Matthew, Sikkema, Kathleen, Susser, Ezra, Ventevogel, Peter, Wessells, Mike, Zambrano López, Aaron, Lovero, Kathryn L., and Greene, M. Claire

Published
2024
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3. Integrating mental health and psychosocial support into economic inclusion programming for displaced families in Ecuador

Author

Arianna Moyano, Daniela Vergara, Amaleah Mirti, Annie G. Bonz, Adriana Monar, Efrén Astudillo, Sara Vaca, Karen Cordova, Andrea Armijos, Adrian Barroso, Cesar Cherrez, Jennie Cottle, Aimée DuBois, Isabella Fernandez Capriles, Jean Pierre Grandes, Matias Irarrazaval, Belen Jaramillo, Jeremy C. Kane, Carmen Martinez-Viciana, Franco Mascayano, Yescárleth Rodríguez, Matthew Schojan, Kathleen Sikkema, Ezra Susser, Peter Ventevogel, Mike Wessells, Aaron Zambrano López, Kathryn L. Lovero, and M. Claire Greene

Subjects
Mental health and psychosocial support, Poverty alleviation, Economic inclusion, Forcibly displaced persons, Special situations and conditions, RC952-1245, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Abstract Background Poverty is a key social determinant of mental health among forcibly displaced persons. This study aimed to design and pilot test a strategy to integrate existing mental health and economic inclusion interventions for displaced families in Ecuador. Methods We conducted a series of qualitative interviews (n = 30), focus groups (n = 6), and workshops (n = 3) to develop a set of strategies for integrating cross-cutting and focused mental health and psychosocial support (MHPSS) strategies into an existing economic inclusion program for displaced families in Quito. We non-randomly assigned two field offices in Quito to (1) integrate cross-cutting strategies focused on improving economic outcomes or (2) integrate both those cross-cutting strategies plus focused MHPSS strategies into an economic inclusion program. We measured site-level implementation outcomes (adoption, appropriateness, acceptability, feasibility, fidelity, reach, retention, usability) and participant-level psychosocial (wellbeing, depressive symptoms, anxiety symptoms, functioning) and economic inclusion outcomes (financial resources, diet diversity, social capital/networks, self-reliance) over six months. We conducted a mixed-methods analysis to explore the acceptability and feasibility of the integration strategies and the ability to evaluate their effects in a future cluster randomized trial. Results We developed a toolkit that included 10 strategies for integrating MHPSS into economic inclusion interventions. Fifty displaced persons participating in an existing economic inclusion program (25 per study condition) were enrolled and 88% remained in the study through the six-month follow-up. Participants and implementers reported that the integration strategy was appropriate, acceptable, feasible, and usable. Implementers, including people without prior experience in delivering mental health services, were able to deliver the intervention with high fidelity. Integration of focused MHPSS intervention components into an economic inclusion program appeared to improve MHPSS outcomes, the strength of social capital and networks, and engagement in economic and other programs. Conclusions This study provides preliminary evidence of the acceptability and feasibility of integrating MHPSS into economic inclusion programs for displaced people. We found evidence supporting evaluation methods that can be employed in a future study to definitively test the added value of integrated approaches to mental health and economic wellbeing for displaced persons.

Published
2024
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5. Greater traditionalism predicts COVID-19 precautionary behaviors across 27 societies.

Author

Samore, Theodore, Fessler, Daniel MT, Sparks, Adam Maxwell, Holbrook, Colin, Aarøe, Lene, Baeza, Carmen Gloria, Barbato, María Teresa, Barclay, Pat, Berniūnas, Renatas, Contreras-Garduño, Jorge, Costa-Neves, Bernardo, Del Pilar Grazioso, Maria, Elmas, Pınar, Fedor, Peter, Fernandez, Ana Maria, Fernández-Morales, Regina, Garcia-Marques, Leonel, Giraldo-Perez, Paulina, Gul, Pelin, Habacht, Fanny, Hasan, Youssef, Hernandez, Earl John, Jarmakowski, Tomasz, Kamble, Shanmukh, Kameda, Tatsuya, Kim, Bia, Kupfer, Tom R, Kurita, Maho, Li, Norman P, Lu, Junsong, Luberti, Francesca R, Maegli, María Andrée, Mejia, Marinés, Morvinski, Coby, Naito, Aoi, Ng'ang'a, Alice, de Oliveira, Angélica Nascimento, Posner, Daniel N, Prokop, Pavol, Shani, Yaniv, Solorzano, Walter Omar Paniagua, Stieger, Stefan, Suryani, Angela Oktavia, Tan, Lynn KL, Tybur, Joshua M, Viciana, Hugo, Visine, Amandine, Wang, Jin, and Wang, Xiao-Tian

Subjects
Humans, Motivation, Public Health, Pandemics, COVID-19, Basic Behavioral and Social Science, Behavioral and Social Science
Abstract

People vary both in their embrace of their society's traditions, and in their perception of hazards as salient and necessitating a response. Over evolutionary time, traditions have offered avenues for addressing hazards, plausibly resulting in linkages between orientations toward tradition and orientations toward danger. Emerging research documents connections between traditionalism and threat responsivity, including pathogen-avoidance motivations. Additionally, because hazard-mitigating behaviors can conflict with competing priorities, associations between traditionalism and pathogen avoidance may hinge on contextually contingent tradeoffs. The COVID-19 pandemic provides a real-world test of the posited relationship between traditionalism and hazard avoidance. Across 27 societies (N = 7844), we find that, in a majority of countries, individuals' endorsement of tradition positively correlates with their adherence to costly COVID-19-avoidance behaviors; accounting for some of the conflicts that arise between public health precautions and other objectives further strengthens this evidence that traditionalism is associated with greater attention to hazards.

Published
2023

6. The Andaluzoʼs adventure: A cluster-randomized controlled trial in Physical Education of a gamified intermittent programming unit with activity wristbands on perceived physical activity and its psychological mediators. Fit Person study

Author

Santiago Guijarro-Romero, Daniel Mayorga-Vega, Carolina Casado-Robles, Pedro Almendral Lara, and Jesús Viciana

Subjects
Medicine, Sports medicine, RC1200-1245
Abstract

The World Health Organization (2020) recommends that schoolchildren achieve at least 60 minutes of daily moderate-to-vigorous physical activity (PA). Unfortunately, only 19% of this population meets this recommendation (Guthold et al., 2020). Physical Education (PE) is an ideal setting to encourage students to practice regular PA (Association for PE, 2020). However, studentsʼ adherence to PA practice is mediated by psychological determinants like motivation (Rhodes et al., 2017) and intention to practice PA (Hagger & Chatzisarantis, 2016). Several strategies like the use of activity wristbands, education counselling (Casado-Robles et al., 2022) or gamification (Arufe-Giráldez et al., 2022) have been shown to be effective for promoting schoolchildrenʼs PA. Consequently, the purpose of this study was to analyse the effect of a gamified intermittent teaching unit based on the use of activity wristbands and behaviour modification strategies on primary school studentsʼ motivation towards PE, their intention to be physically active and their perceived PA. A sample of 182 primary school students (39% females; Mage = 10.1 ± 0.9 years old) was cluster-randomly assigned to the control group (CG, n = 80) and gamified group (GG, n = 102). The GG students performed a gamified intermittent teaching unit (Viciana & Mayorga-Vega, 2016) based on the use of activity wristbands, educational counselling and goal-setting strategies three times per week during five weeks. Specifically, the first 15 minutes of each lesson were used. The narrative of the intervention was a travel performed by its main character, “Andaluzo”, through the provinces of the Andalucia region. Before and after the intervention, students filled out the Spanish versions of the Motivation in PE (Miguel Leo et al., 2016), intention to be physically active (Arias-Estero et al., 2013), and Pictorial Childrenʼs PA (Morera-Castro et al., 2018) questionnaires. The Mann-Whitney U test showed statistically significant differences in identified regulation, autonomous motivation towards PE, and PA performed during school recess (p < 0.05). No statistically significant differences were found for the rest of the variables (p > 0.05). Results of this study suggest that a gamified intermittent teaching unit based on the use of activity wristbands and behaviour modification strategies seems to be effective for improving schoolchildrenʼs autonomous motivation towards PE, as well as PA performed during recess. Nevertheless, future research is needed to incorporate other social agents, such as parents or tutors, to try to obtain improvements in weekly PA, as well as in the different periods of it.

Published
2024

7. Could an intermittent programming unit based on the use of activity wristbands in Physical Education improve adolescentsʼ objective habitual physical activity and sedentary behavior levels? A cluster-randomized controlled trial. Fit-Person study

Author

Jesús Viciana, Daniel Mayorga-Vega, Carolina Casado-Robles, Pedro Almendral Lara, and Santiago Guijarro-Romero

Subjects
Medicine, Sports medicine, RC1200-1245
Abstract

The benefits of regular PA practice have been clearly proved by research in previous literature (World Health Organization, 2020). Unfortunately, most children and adolescents do not accomplish the recommendations (60 minutes daily of moderate-to-vigorous PA) (Guthold et al., 2020). According to this situation, promoting adequate levels of PA in schoolchildren is a priority public health challenge. Consequently, this study aimed to analyse the effect of an intermittent teaching unit based on activity wristbands and behaviour modification strategies on habitual PA and SB levels in high school students in the Physical Education (PE) context. Following a cluster-randomized controlled trial, 176 participants (45.5% females) aged between 11-17 years old were divided into a control group (CG, n = 76) and an experimental group (EG, n = 100). The EG performed an intermittent teaching unit (Viciana & Mayorga-Vega, 2016) during eight weeks (with two PE sessions a week). Using scientific evidence regarding the use of behaviour modification techniques towards more active behaviour (Casado-Robles et al., 2022), PA wristbands, educational counselling, progressive objectives toward 10000 steps/day, and alerts and messages to encourage active behaviour were applied during the last 15 minutes of the 16 PE sessions. Objective measurements of PA and SB were registered by GT3X+ accelerometers during eight days with a one-second epochs before and after the intervention. Results of the Multilevel Lineal Model did not show statistically significant differences in PA variables (i.e., light PA, moderate-to-vigorous PA, steps per day) or SB between participants in the CG and the EG (p > 0.05). In previous research, the results of comparable interventions have been similar. For instance, Corepal et al. (2019) did not find any positive results in their 22-week intervention using the Fitbit Zip monitor in adolescents. Evans et al. (2017) with an intervention of six weeks, Kerner et al. (2019) with a five-week intervention program, and Remmert et al. (2019) with a 12-week program did not find any positive results either. Although it has been shown that wearing a PA wristband is considered a highly recommended tool to increase motivation towards PA practice in schoolchildren (Casado-Robles et al., 2022), as they have a great affinity to new technologies, it seems that similar to previous cases, short programs have not had positive results in changing active behaviour in PE setting.

Published
2024

9. Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome.

Author

Bonsor, Daniel, Alexander, Patrick, Snead, Kelly, Hartig, Nicole, Drew, Matthew, Messing, Simon, Finci, Lorenzo, Nissley, Dwight, Esposito, Dominic, Rodriguez-Viciana, Pablo, Stephen, Andrew, Simanshu, Dhirendra, and Mccormick, Frank

Subjects
Humans, Intracellular Signaling Peptides and Proteins, MAP Kinase Signaling System, Mitogen-Activated Protein Kinase Kinases, Noonan Syndrome, Phosphoserine, Protein Phosphatase 1, Proto-Oncogene Proteins p21(ras), raf Kinases, ras Proteins
Abstract

SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell lines. SHOC2 forms a heterotrimeric complex with MRAS and PP1C that is essential for regulating RAF and MAPK-pathway activation by dephosphorylating a specific phosphoserine on RAF kinases. Here we present the high-resolution crystal structure of the SHOC2-MRAS-PP1C (SMP) complex and apo-SHOC2. Our structures reveal that SHOC2, MRAS, and PP1C form a stable ternary complex in which all three proteins synergistically interact with each other. Our results show that dephosphorylation of RAF substrates by PP1C is enhanced upon interacting with SHOC2 and MRAS. The SMP complex forms only when MRAS is in an active state and is dependent on SHOC2 functioning as a scaffolding protein in the complex by bringing PP1C and MRAS together. Our results provide structural insights into the role of the SMP complex in RAF activation and how mutations found in Noonan syndrome enhance complex formation, and reveal new avenues for therapeutic interventions.

Published
2022

10. Development of an Earth-Field Nuclear Magnetic Resonance Spectrometer: Paving the Way for AI-Enhanced Low-Field Nuclear Magnetic Resonance Technology

Author

Eduardo Viciana, Juan Antonio Martínez-Lao, Emilio López-Lao, Ignacio Fernández, and Francisco Manuel Arrabal-Campos

Subjects
Earth’s field NMR, NMR spectrometer, EFNMR, Chemical technology, TP1-1185
Abstract

Today, it is difficult to have a high-field nuclear magnetic resonance (NMR) device due to the high cost of its acquisition and maintenance. These high-end machines require significant space and specialist personnel for operation and offer exceptional quality in the acquisition, processing, and other advanced functions associated with detected signals. However, alternative devices are low-field nuclear magnetic resonance devices. They benefit from the elimination of high-tech components that generate static magnetic fields and advanced instruments. Instead, they used magnetic fields induced by ordinary conductors. Another category of spectrometers uses the Earth’s magnetic field, which is simple and economical but limited in use. These devices are called Earth-Field Nuclear Magnetic Resonance (EFNMR) devices. This device is ideal for educational purposes, especially for engineers and those who study nuclear magnetic resonance, such as chemistry or other experimental sciences. Students can observe their internal workings and conduct experiments that complement their education without worrying about damaging equipment. This article provides a detailed explanation of the design and construction of electrical technology devices for the excitation of atomic spin resonance using Earth’s magnetic fields. It covers all necessary stages, from research to analysis, including simulation, assembly, construction of each component, and the development of comprehensive software for spectrometer control.

Published
2024
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11. Pre-Service Teachers' Perception on Their EFL Competence and Professional Requirements

Author

Ramos-García, Ana María and Fernández-Viciana, Ana

Abstract

Language teaching and teaching through language have undergone a standardization process all over Europe. In the Spanish context, a myriad of programs has emerged in the last ten years whose main aim is to guarantee a plurilingual education. That means implementing and consolidating European directives on the matter from the Council of Europe. Universities have joined this trend in their need for internationalization. This contribution analyses pre-service teachers' perceptions on their English Foreign Language level and the professional requirements regarding language competence in the current context in which language is a key aspect in education at any level. In spite of the fact that most students (95.5%) consider that a language teacher should master the language (C1 CEFR level or at least B2), some of them (19.3%) acknowledge not having any language accreditation yet, and most are in between B1 and B2 (70%). Therefore, there is a lack of consistency between their real language level and their perception of what is needed in order to be a successful primary education language teacher. Unquestioningly, their desired level is above their real competence, that is the reason why they plan to continue their English studies once they finish their university degree.

Published
2019

12. The Youth Fitness International Test (YFIT) battery for monitoring and surveillance among children and adolescents: A modified Delphi consensus project with 169 experts from 50 countries and territories

Author

Oyeyemi, Adewale L., Marques, Adilson, Gribbon, Aidan, Gaya, Anelise Reis Reis, García-Hermoso, Antonio, Sääkslahti, Arja, Faigenbaum, Avery, Nakabazzi, Bernadette, Leskošek, Bojan, Popovic, Boris, O'Keeffe, Brendan, Timmons, Brian W., Mieziene, Brigita, Fraser, Brooklyn, Brand, Caroline, Anza-Ramirez, Cecilia, Alvarez-Bueno, Celia, Agostinis-Sobrinho, Cesar A., Hillman, Charles H., Niessner, Claudia, Drenowatz, Clemens, Magnussen, Costan G., Cadenas-Sanchez, Cristina, Berglind, Daniel, da Silva, Danilo Rodrigues Pereira, Colella, Dario, Lubans, David, Matelot, David, Tladi, Dawn M., Silva, Diego Augusto Santos, Moliner-Urdiales, Diego, Dumuid, Dot, Blain, Dylan, Ulloa, Edtna Jáuregui, Arunas, Emeljanovas, Pintos-Toledo, Enrique, Poon, Eric Tsz Chun, Lee, Eun-Young, Riso, Eva Maria, Mäestu, Evelin, Bardid, Farid, Cañete, Felicia, Rodríguez, Fernando Rodríguez, De Roia, Gabriela, Tabacchi, Garden, Stratton, Gareth, Sandercock, Gavin R., Georgiev, Georgi, Vicente-Rodríguez, Germán, Ferrari, Gerson, Rosa, Gil, Welk, Greg, Jurak, Gregor, Starc, Gregor, Labayen, Idoia, Cigarroa, Igor, Esteban-Cornejo, Irene, Emeterio, Iván Clavel San, Milanović, Ivana, Clarke, Janine, Dobosz, Janusz, Mäestu, Jarek, Brazo-Sayavera, Javier, Sacheck, Jennifer, Servais, Jennifer, Secchi, Jeremías David, Vanhelst, Jérémy, Ramírez, Jesús Viciana, Magalhães, João, Soto-Sánchez, Johana, Jaunig, Johannes, Reilly, John J., Smith, Jordan, Mota, Jorge, Castro-Piñero, Jose, López-Gil, José Francisco, Githang'a, Juliah Wambui, Mello, Júlio Brugnara, Janz, Kathleen, Weston, Kathryn L., Laurson, Kelly, Till, Kevin, Dlamini, Khanyile, Tambalis, Konstantinos D., Basterfield, Laura, Joensuu, Laura, Béghin, Laurent, Santos, Leandro dos, Mugisha, Lillian, Zou, Liye, Taylor, Juan Ricardo López Y, Štefan, Lovro, Léger, Luc, Wachira, Lucy-Joy, Sardinha, Luís B., Rubin, Lukas, Thuany, Mabliny, Cuenca-García, Magdalena, Paw, Mai Chin A, Sanchez-Lopez, Mairena, Pihu, Maret, Noriega, Maria Jose, Medrano-Echeverría, María, Beltran-Valls, Maria Reyes, Löf, Marie, Misigoj-Durakovic, Marjeta, Tremblay, Mark, Gerber, Markus, Sorić, Maroje, Giuriato, Matteo, Vandoni, Matteo, Lenoir, Matthieu, Santander, Mauro D., Peralta, Miguel, Huhtiniemi, Mikko, Said, Mohamed Ahmed, Kaj, Mónika, Burn, Naomi, Ridgers, Nicola D., Lovecchio, Nicola, Aguilar-Farias, Nicolas, Wedderkopp, Niels, Veiga, Oscar L., Saint-Maurice, Pedro, Katzmarzyk, Peter, Henriksson, Pontus, Colley, Rachel, Ocansey, Reginald T-A., Kliegl, Reinhold, Ramírez-Vélez, Robinson, Ssenyonga, Ronald, Naidoo, Rowena, Pate, Russell R., McGrath, Ryan, Kuu, Saima, Salaj, Sanja, Gontarev, Seryozha, Morrison, Shawnda A., Nqweniso, Siphesihle, Chen, Sitong, Kagunda, Stanley, Ware, Stephanie Prince, Wong, Stephen H., Popovic, Stevo R., Fairclough, Stuart J., Andrade, Susana, Kriemler, Susi, Csányi, Tamás, Manyanga, Taru, Mwase-Vuma, Tawonga W., Kidokoro, Tetsu, Gomes, Thayse Natacha, Gisladottir, Thordis, Takken, Tim, Jaakkola, Timo, Lakka, Timo, Olds, Timothy, Tammelin, Tuija, Granacher, Urs, Carson, Valerie, Martinez-Vizcaino, Vincent, Onywera, Vincent, Pellino, Vittoria Carnevale, Huang, Wendy Y., Yin, Xiaojian, Liu, Yang, Song, Yi, Sun, Yi, Liu, Yuan, Ortega, Francisco B., Zhang, Kai, Tremblay, Mark S., Tomkinson, Grant R., Ruiz, Jonatan R., Keller, Katja, Nyström, Christine Delisle, Pate, Russell, Kidokoro, Tetsuhiro, Poon, Eric, Wachira, Lucy-Joy M., Gomes, Thayse Natacha Q.F., Cristi-Montero, Carlos, Fraser, Brooklyn J., Onywera, Vincent O., Liang, Li-Lin, Prince, Stephanie A., Lubans, David R., and Lang, Justin J.

Published
2024
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17. Optimization of the molecular diagnosis of the acute hepatitis E virus infection

Author

Pedro Lopez‐Lopez, Mario Frias, Ana Belén Perez‐Jimenez, Carolina Freyre‐Carrillo, Juan A. Pineda, Antonio Aguilera, Ana Fuentes, Juan Carlos Alados, Gabriel Reina, Encarnación Ramirez‐Arellano, Isabel Viciana, Joao Mesquita, Javier Caballero‐Gomez, Antonio Rivero‐Juarez, Antonio Rivero, and for the HEPAVIR and GEHEP‐014 Study Groups

Subjects
Biotechnology, TP248.13-248.65
Abstract

Abstract To evaluate the diagnostic value of the combination of two broad‐range PCR assays targeting two different and conserved regions of the viral genome for the diagnosis of acute Hepatitis E virus (HEV) infection. Patients with acute hepatitis were prospectively recruited. In all, HEV‐IgM antibodies were tested together with evaluation of HEV viraemia by two PCR assays (ORF3 and ORF1). The number of individuals exhibiting negative IgM antibody results but carrying viral RNA was calculated by each PCR assay. Four‐hundred and seventy individuals were included, of whom 145 (30.8%) were diagnosed as having acute HEV. Of them, 122 (84.1%) exhibited HEV‐IgM antibodies, and 81 (55.8%) had detectable viral RNA for at least one PCR. Using the ORF3 molecular assay, 70 (48.3%) individuals were identified with HEV infection. When the ORF1 molecular assay was applied, 49 (33.8%) individuals were identified. The ORF3 assay detected viral RNA in 32 patients not detected by the ORF1 assay. In contrast, the ORF1 assay could amplify viral RNA in 11 patients who were not detected by the ORF3 assay. The parallel use of two broad‐range PCR assays significantly increased the performance of the molecular diagnosis of HEV.

Published
2023
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18. Greater traditionalism predicts COVID-19 precautionary behaviors across 27 societies

Author

Theodore Samore, Daniel M. T. Fessler, Adam Maxwell Sparks, Colin Holbrook, Lene Aarøe, Carmen Gloria Baeza, María Teresa Barbato, Pat Barclay, Renatas Berniūnas, Jorge Contreras-Garduño, Bernardo Costa-Neves, Maria del Pilar Grazioso, Pınar Elmas, Peter Fedor, Ana Maria Fernandez, Regina Fernández-Morales, Leonel Garcia-Marques, Paulina Giraldo-Perez, Pelin Gul, Fanny Habacht, Youssef Hasan, Earl John Hernandez, Tomasz Jarmakowski, Shanmukh Kamble, Tatsuya Kameda, Bia Kim, Tom R. Kupfer, Maho Kurita, Norman P. Li, Junsong Lu, Francesca R. Luberti, María Andrée Maegli, Marinés Mejia, Coby Morvinski, Aoi Naito, Alice Ng’ang’a, Angélica Nascimento de Oliveira, Daniel N. Posner, Pavol Prokop, Yaniv Shani, Walter Omar Paniagua Solorzano, Stefan Stieger, Angela Oktavia Suryani, Lynn K. L. Tan, Joshua M. Tybur, Hugo Viciana, Amandine Visine, Jin Wang, and Xiao-Tian Wang

Subjects
Medicine, Science
Abstract

Abstract People vary both in their embrace of their society’s traditions, and in their perception of hazards as salient and necessitating a response. Over evolutionary time, traditions have offered avenues for addressing hazards, plausibly resulting in linkages between orientations toward tradition and orientations toward danger. Emerging research documents connections between traditionalism and threat responsivity, including pathogen-avoidance motivations. Additionally, because hazard-mitigating behaviors can conflict with competing priorities, associations between traditionalism and pathogen avoidance may hinge on contextually contingent tradeoffs. The COVID-19 pandemic provides a real-world test of the posited relationship between traditionalism and hazard avoidance. Across 27 societies (N = 7844), we find that, in a majority of countries, individuals’ endorsement of tradition positively correlates with their adherence to costly COVID-19-avoidance behaviors; accounting for some of the conflicts that arise between public health precautions and other objectives further strengthens this evidence that traditionalism is associated with greater attention to hazards.

Published
2023
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19. Adult T-cell leukemia/lymphoma in HTLV-1 non-endemic regions

Author

Calderón, E., Rodríguez-Iglesias, M., Montiel, N., Trujillo, T., Viciana, I., Cabezas, T., Lozano, A., Fernández-Fuertes, E., Fernández, J.M., García, F., Benito, R., Algarate, S., Ducons, M., Roc, L., Cifuentes, C., Fernández-Baca, V., Fernández-Montero, J.V, Maciá, MD., Hernández-Betancor, A., Martín, A.M., Pena, M.J., Hernández, M., López-Lirola, A.M., Gómez-Sirvent, J.L., Copado, R., Cano, M.E., Rojo, S., Eirós, J.M., Rodríguez, M., Gómez-Hernando, C., González-Praetorius, A., Rando, A., Force, L., Miró, E., Cebollero, A., Delgado, J.F., Rodríguez, G., Fernández-Pereira, L., Aguilera, A., Pereira, S., García, J., Trigo, M., Diz, J., García-Campello, M., Cortizo, S., Pérez, S., Morano, L., Reina, G., Arazamendi, M., Salicio, Y., Ugalde, E., Nieto, M.C., Liendo, P., Goikoetxea, A.J., Ocete, M.D., Ramos, J.M., Escribano, I., Sauleda, S., Pirón, M., González, R., Richart, A., Barea, L., Jiménez, A., Blanco, L., Navarro, L., Ayerdi, O., Baza, B., Rodriguez, C., del Romero, J., Galar, A., Aldamiz, T., Valeiro, M., Pérez, L., Rodríguez-Avial, I., Martín-Carbonero, L., Fernández-Ruiz, M., Parra, P., Redondo, N., Ruiz-Merlo, T., Pozuelo, M.J., Barreiro, P., Treviño, A., Corral, O., Soriano, V., Pintos, I., Moreno-Torres, V., Carrizo, P., Huertas, A., Vargas-Núñez, J.A., de Mendoza, C., de Mendoza, Carmen, Rando, Ariadna, Miró, Elisenda, Pena, María José, Rodríguez-Avial, Iciar, Ortega, Diego, González-Praetorius, Alejandro, Reina, Gabriel, Pintos, Ilduara, Pozuelo, María José, and Soriano, Vicente

Published
2023
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20. Cell-cell adhesion regulates Merlin/NF2 interaction with the PAF complex

Author

Roehrig, Anne E, Klupsch, Kristina, Oses-Prieto, Juan A, Chaib, Selim, Henderson, Stephen, Emmett, Warren, Young, Lucy C, Surinova, Silvia, Blees, Andreas, Pfeiffer, Anett, Tijani, Maha, Brunk, Fabian, Hartig, Nicole, Muñoz-Alegre, Marta, Hergovich, Alexander, Jennings, Barbara H, Burlingame, Alma L, and Rodriguez-Viciana, Pablo

Subjects
Biochemistry and Cell Biology, Biological Sciences, Genetics, Rare Diseases, Neurofibromatosis, Neurosciences, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Aetiology, Underpinning research, Cancer, Cell Adhesion, Cell Proliferation, Chromatin, Chromatin Assembly and Disassembly, Contact Inhibition, DNA Helicases, DNA-Binding Proteins, Gene Expression Regulation, HEK293 Cells, Humans, Neoplasms, Neurofibromin 2, Protein Binding, Protein Interaction Maps, Signal Transduction, Tumor Suppressor Proteins, General Science & Technology
Abstract

The PAF complex (PAFC) coordinates transcription elongation and mRNA processing and its CDC73/parafibromin subunit functions as a tumour suppressor. The NF2/Merlin tumour suppressor functions both at the cell cortex and nucleus and is a key mediator of contact inhibition but the molecular mechanisms remain unclear. In this study we have used affinity proteomics to identify novel Merlin interacting proteins and show that Merlin forms a complex with multiple proteins involved in RNA processing including the PAFC and the CHD1 chromatin remodeller. Tumour-derived inactivating mutations in both Merlin and the CDC73 PAFC subunit mutually disrupt their interaction and growth suppression by Merlin requires CDC73. Merlin interacts with the PAFC in a cell density-dependent manner and we identify a role for FAT cadherins in regulating the Merlin-PAFC interaction. Our results suggest that in addition to its function within the Hippo pathway, Merlin is part of a tumour suppressor network regulated by cell-cell adhesion which coordinates post-initiation steps of the transcription cycle of genes mediating contact inhibition.

Published
2021

21. Effect of an Inside-Outside School Alternated Teaching Unit of Knowledge of the Environment for Practicing Physical Activity: A Cluster Randomized Control Trial

Author

Casado-Robles, Carolina, Viciana, Jesús, Guijarro-Romero, Santiago, and Mayorga-Vega, Daniel

Abstract

Purpose: To examine the effect of two physical education-based alternated teaching units on students' environmental knowledge for practicing out-of-school physical activity (PA), perceived autonomy support, self-determined and controlled motivation toward PA, intention to be physically active, self-reported and objective PA levels, and sedentary behavior. Method: A sample of 179 students (94 females) aged 13-15 years old was cluster randomly assigned to the innovative group (two alternated teaching units for practicing PA, with one lesson inside and one outside the school grounds) or the traditional group (a teaching unit for practicing PA, solely inside the school center). Results: The alternated teaching units improved students' knowledge of their environment for practicing PA, perceived autonomy, autonomous motivation, intention to be physically active, and self-reported PA during the whole week (p < 0.05). Discussion/Conclusion: The innovative program improved students' knowledge about their environment for practicing PA and self-reported PA but did not improve objectively measured PA levels.

Published
2022
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22. The Town Crier: A Use-Case Design and Implementation for a Socially Assistive Robot in Retirement Homes

Author

Ana Iglesias, Raquel Viciana, José Manuel Pérez-Lorenzo, Karine Lan Hing Ting, Alberto Tudela, Rebeca Marfil, Malak Qbilat, Antonio Hurtado, Antonio Jerez, and Juan Pedro Bandera

Subjects
social robot, well-being, human-centred design, participatory design, human–robot interfaces, Mechanical engineering and machinery, TJ1-1570
Abstract

The use of new assistive technologies in general, and Socially Assistive Robots (SARs) in particular, is becoming increasingly common for supporting people’s health and well-being. However, it still faces many issues regarding long-term adherence, acceptability and utility. Most of these issues are due to design processes that insufficiently take into account the needs, preferences and values of intended users. Other issues are related to the currently very limited amount of long-term evaluations, performed in real-world settings, for SARs. This study presents the results of two regional projects that consider as a starting hypothesis that the assessment in controlled environments and/or with short exposures may not be enough in the design of an SAR deployed in a retirement home and the necessity of designing for and with users. Thus, the proposed methodology has focused on use-cases definitions that follow a human-centred and participatory design approach. The main goals have been facilitating system acceptance and attachment by involving stakeholders in the robots design and evaluation, overcoming usage barriers and considering user’s needs integration. The implementation of the first use-case deployed and the two-phase pilot test performed in a retirement home are presented. In particular, a detailed description of the interface redesign process based on improving a basic prototype with users’ feedback and recommendations is presented, together with the main results of a formal evaluation that has highlighted the impact of changes and improvements addressed in the first redesign loop of the system.

Published
2024
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23. Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS events

Author

Jarrín, Inma, Dalmau, David, Navarro, M. Luisa, González, M. Isabel, Garcia, Federico, Poveda, Eva, Iribarren, Jose Antonio, Gutiérrez, Félix, Rubio, Rafael, Vidal, Francesc, Berenguer, Juan, González, Juan, Muñoz-Fernández, M. Ángeles, Jarrín, Inmaculada, Moreno, Cristina, Rava, Marta, Izquierdo, Rebeca, Mauleón, Elba, Portilla, Joaquín, Portilla, Irene, Merino, Esperanza, García, Gema, Agea, Iván, Sánchez-Payá, José, Rodríguez, Juan Carlos, Giner, Livia, Reus, Sergio, Boix, Vicente, Torrus, Diego, Pérez, Verónica, Portilla, Julia, Gómez, Juan Luís, Hernández, Jehovana, Lirola, Ana López, García, Dácil, Díaz-Flores, Felicitas, Alonso, M. Mar, Pelazas, Ricardo, Alemán, M. Remedios, Asensi, Víctor, Rivas Carmenado, María Eugenia, Suarez-Zarracina, Tomás, Pulido, Federico, Bisbal, Otilia, Hernando, M. Asunción, Rial, David, de Lagarde, María, Arce, Octavio, Pinto, Adriana, Bermejo, Laura, Santacreu, Mireia, Navarro, Roser, Gonzalez, Candela, Aramburu, M. José, Camino, Xabier, Ángel von Wichmann, Miguel, Goenaga, Miguel Ángel, Bustinduy, M. Jesús, Azkune, Harkaitz, Ibarguren, Maialen, Kortajarena, Xabier, Álvarez-Rodriguez, Ignacio, Gil, Leire, Martínez, Lourdes, Robledano, Catalina, Masiá, Mar, Padilla, Sergio, Adsuar, Araceli, Pascual, Rafael, Fernández, Marta, Galiana, Antonio, García, José Alberto, Barber, Xavier, Agullo, Vanessa, Abellán, Javier Garcia, Pascual, Reyes, Telenti, Guillermo, Guillén, Lucia, Botella, Ángela, Muga, Roberto, Sanvisens, Arantza, Fuster, Daniel, Gutierrez, Isabel, López, Juan Carlos, Ramírez, Margarita, Padilla, Belén, Gijón, Paloma, Aldamiz-Echevarría, Teresa, Tejerina, Francisco, Diez, Cristina, Pérez, Leire, Fanciulli, Chiara, Corral, Saray, Martí, Anna, Peraire, Joaquín, Viladés, Consuelo, Vargas, Montserrat, Olona, Montserrat, Rull, Anna, Alba, Verónica, Yeregui, Elena, Masip, Jenifer, García-Pardo, Graciano, Bertomeu, Frederic Gómez, Espineira, Sonia, Montero, Marta, Cuéllar, Sandra, Blanes, Marino, Tasias, María, Calabuig, Eva, Salavert, Miguel, Fernández, Juan, Segarra, Inmaculada, González-García, Juan, Delgado, Ana, Arnalich, Francisco, Arribas, José Ramón, Bernardino, Jose Ignacio, Castro, Juan Miguel, Escosa, Luis, Herranz, Pedro, Hontañón, Victor, García-Bujalance, Silvia, García, Milagros, González-Baeza, Alicia, Martín-Carbonero, M. Luz, Mayoral, Mario, Mellado, M. Jose, Esteban, Rafael, Montejano, Rocío, Montes, M. Luisa, Moreno, Victoria, Pérez-Valero, Ignacio, Rodés, Berta, Rúa, Guadalupe, Sainz, Talía, Sendagorta, Elena, Valencia, Eulalia, Busca, Carmen, Cano, Joanna, Cardiñanos, Julen, de Miguel, Rosa, Blanco, Jose Ramón, Pérez-Martínez, Laura, Oteo, José Antonio, Ibarra, Valvanera, Metola, Luis, Sanz, Mercedes, Arazo, Piedad, Sampériz, Gloria, Martinez, Marina, Jaén, Angels, Sanmartí, Montse, Cairó, Mireia, Martinez-Lacasa, Javier, Velli, Pablo, Font, Roser, Xercavins, Mariona, Alonso, Noemí, Aiello, Francesco, Rivero, María, Piérola, Beatriz, Goikoetxea, Maider, Gracia, María, Ibero, Carlos, Moreno, Estela, Repáraz, Jesús, Navarro, Gemma, Garcia, Manel Cervantes, Isbert, Sonia Calzado, Vilasaro, Marta Navarro, Garcia, Belen Lopez, Santos, Ignacio de los, Santos, Alejandro de los, Sanz, Jesús, García-Fraile, Lucio, Martín, Enrique, Sánchez-Cerrillo, Ildefonso, Calvet, Marta, Barrios, Ana, Bautista, Azucena, Sáez, Carmen, Ciudad, Marianela, Gutiérrez, Ángela, Moreno, Santiago, Campo, Santos del, Casado, José Luis, Dronda, Fernando, Moreno, Ana, Pérez, M. Jesús, Serrano, Sergio, Vivancos, M<ce:sup loc='post">a</ce:sup> Jesús, Martínez-Sanz, Javier, Vallejo, Alejandro, Sanchez, Matilde, Pérez-Molina, Jose Antonio, Hermida, José Manuel, Bernal, Enrique, Alcaraz, Antonia, Bravo, Joaquín, Muñoz, Ángeles, Tomás, Cristina, Martínez, Mónica, Villalba, M. Carmen, García, Federico, Martínez, Clara, Hernández, José, Medina, Leopoldo Muñoz, Álvarez, Marta, Chueca, Natalia, Vinuesa, David, de Salazar, Adolfo, Fuentes, Ana, Guirao, Emilio, Viñuela, Laura, Ruiz-Sancho, Andrés, Anguita, Francisco, Del Romero, Jorge, Raposo, Montserrat, Rodríguez, Carmen, Puerta, Teresa, Carrió, Juan Carlos, Vera, Mar, Ballesteros, Juan, Ayerdi, Oskar, Baza, Begoña, Orviz, Eva, Antela, Antonio, Losada, Elena, Riera, Melchor, Peñaranda, María, Ribas, M. Angels, Campins, Antoni A., Garcia-Gazalla, Mercedes, Fanjul, Francisco J., Murillas, Javier, Homar, Francisco, Vilchez, Helem H., Martin, Luisa, Payeras, Antoni, Santos, Jesús, López, María, Gómez, Crisitina, Viciana, Isabel, Palacios, Rosario, López-Cortés, Luis Fernando, Espinosa, Nuria, Roca, Cristina, Llaves, Silvia, Tiraboschi, Juan Manuel, Imaz, Arkaitz, Silva, Ana Karina, Saumoy, María, Scévola, Sofía Catalina, Curran, Adrián, Falcó, Vicenç, Navarro, Jordi, Burgos, Joaquin, Suanzes, Paula, García, Jorge, Descalzo, Vicente, Álvarez, Patricia, Planas, Bibiana, Sanchiz, Marta, Rodríguez, Lucía, Olalla, Julián, Sánchez, M José, Pérez, Javier, Arco, Alfonso del, Torre, Javier de la, Prada, José Luis, Martínez, Onofre Juan, Martinez, Lorena, Vera, Francisco Jesús, García, Josefina, Alcaraz, Begoña, Sánchez Guirao, Antonio Jesús, Mena, Alvaro, Castro, Angeles, Pernas, Berta, Vázquez, Pilar, López, Soledad, Ibarra, Sofía, García, Guillermo, Mirena, Josu, Ferrero, Oscar Luis, López, Josefina, Cámara, M. Mar, Peña, Mireia de la, Lopez, Miriam, Lopez, Iñigo, Lombide, Itxaso, Polo, Victor, de Miguel, Joana, Galera, Carlos, Fernández, Marian, Albendin, Helena, Castillo, Antonia, Iborra, Asunción, Moreno, Antonio, Merlos, M. Angustias, Vidal, Asunción, Amador, Concha, Pasquau, Francisco, Gil, Concepcion, Algado, Jose Tomás, Suarez-García, Inés, Malmierca, Eduardo, González-Ruano, Patricia, Ruiz, M. Pilar, Pascual, José Francisco, Sáez, Elena, Balsalobre, Luz, López, M. Villa, Omar, Mohamed, Herrero, Carmen, Gómez, M. Amparo, Alberto de Zarraga, Miguel, Pérez, Desiré, Estrada, Vicente, Sanz, Nieves, Cabello, Noemí, García, Jorge Vergas, Núñez, Maria Jose, Sagastagoitia, Iñigo, Górgolas, Miguel, Cabello, Alfonso, Álvarez, Beatriz, Prieto, Laura, Carrillo, Irene, Sanz, José, Arranz, Alberto, Hernández, Cristina, Novella, María, Galindo, M. José, Ferrer, Ana, Román, Antonio Rivero, Ruíz, Inma, Juárez, Antonio Rivero, López, Pedro, Machuca, Isabel, Frias, Mario, Camacho, Ángela, Pérez, Ignacio, Corona, Diana, Cervero, Miguel, Torres, Rafael, Pineda, Juan Antonio, Rincón, Pilar, Macías, Juan, Real, Luis Miguel, Corma, Anais, Gonzalez-Serna, Alejandro, Pérez, Alexandre, Morano, Luis, Miralles, Celia, Ocampo, Antonio, Pousada, Guillermo, Patiño, Lucía, Dueñas, Carlos, Gutiérrez, Sara, Tapia, Elena, Novoa, Cristina, Egües, Xjoylin, Telleria, Pablo, Díaz-Álvarez, Jorge, Rosas Cancio-Suarez, Marta, Ron, Raquel, Iribarren, José Antonio, Ruiz Sancho, Andrés, Cabello, Noemi, and Serrano-Villar, Sergio

Published
2023
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24. The sixth international RASopathies symposium: Precision medicine-From promise to practice.

Author

Gripp, Karen W, Schill, Lisa, Schoyer, Lisa, Stronach, Beth, Bennett, Anton M, Blaser, Susan, Brown, Amanda, Burdine, Rebecca, Burkitt-Wright, Emma, Castel, Pau, Darilek, Sandra, Dias, Alwyn, Dyer, Tuesdi, Ellis, Michelle, Erickson, Gregg, Gelb, Bruce D, Green, Tamar, Gross, Andrea, Ho, Alan, Holder, James Lloyd, Inoue, Shin-Ichi, Jelin, Angie C, Kennedy, Annie, Klein, Richard, Kontaridis, Maria I, Magoulas, Pilar, McConnell, Darryl B, McCormick, Frank, Neel, Benjamin G, Prada, Carlos E, Rauen, Katherine A, Roberts, Amy, Rodriguez-Viciana, Pablo, Rosen, Neal, Rumbaugh, Gavin, Sablina, Anna, Solman, Maja, Tartaglia, Marco, Thomas, Angelica, Timmer, William C, Venkatachalam, Kartik, Walsh, Karin S, Wolters, Pamela L, Yi, Jae-Sung, Zenker, Martin, and Ratner, Nancy

Subjects
Humans, Genetic Diseases, Inborn, ras Proteins, Mitogen-Activated Protein Kinase Kinases, Signal Transduction, Germ-Line Mutation, Costello syndrome, Noonan syndrome, RASopathy, cardio-facio-cutaneous syndrome, kinases, neurofibromatosis, Rare Diseases, Genetics, Good Health and Well Being, Clinical Sciences
Abstract

The RASopathies are a group of genetic disorders that result from germline pathogenic variants affecting RAS-mitogen activated protein kinase (MAPK) pathway genes. RASopathies share RAS/MAPK pathway dysregulation and share phenotypic manifestations affecting numerous organ systems, causing lifelong and at times life-limiting medical complications. RASopathies may benefit from precision medicine approaches. For this reason, the Sixth International RASopathies Symposium focused on exploring precision medicine. This meeting brought together basic science researchers, clinicians, clinician scientists, patient advocates, and representatives from pharmaceutical companies and the National Institutes of Health. Novel RASopathy genes, variants, and animal models were discussed in the context of medication trials and drug development. Attempts to define and measure meaningful endpoints for treatment trials were discussed, as was drug availability to patients after trial completion.

Published
2020

25. Temporal changes in the genotypes of Paslahepevirus balayani in southern Spain and their possible link with changes in pig trade imports

Author

Lopez-Lopez, Pedro, Frias, Mario, Perez-Jimenez, Ana Belén, Freyre-Carrillo, Carolina, Pineda, Juan A., Fuentes, Ana, Alados, Juan Carlos, Ramirez-Arellano, Encarnación, Viciana, Isabel, Corona-Mata, Diana, Caballero-Gomez, Javier, Garcia-Bocanegra, Ignacio, Risalde, María A., Rivero-Juarez, Antonio, and Rivero, Antonio

Published
2023
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29. Effect of an activity wristband-based intermittent teaching unit in Physical Education on studentsʼ physical activity and its psychological mediators: a cluster-randomized controlled trial. School-fit study

Author

Santiago Guijarro-Romero, Daniel Mayorga-Vega, Carolina Casado-Robles, and Jesús Viciana

Subjects
innovative program, wrist-worn wearables, autonomy support, motivation, physical activity levels, trans-contextual model, Psychology, BF1-990
Abstract

ObjectiveThe main objective of the present study was to examine the effects of an intermittent teaching unit based on the use of activity wristbands and behavior modification strategies on high school studentsʼ perceptions of autonomy support, satisfaction of basic psychological needs, motivation toward Physical Education and physical activity, intention to be physically active, and habitual physical activity levels.Materials and methodsAn initial sample of 353 high school students (final sample = 175; 45.7% females; mean age = 13.3 ± 1.2 years) from two public high schools were cluster-randomly assigned into the intermittent (IG, n = 100) and control (CG, n = 75) groups. The IG performed an intermittent teaching unit twice a week for eight weeks. Specifically, the last 15 min of each lesson were used. As the main strategy to promote the practice of regular physical activity, students wore an activity wristband the whole day during the intervention period. Additionally, other behavior modification strategies were also applied (e.g., educational counseling, physical activity goals or reminders). Regarding the CG, during the intervention period (i.e,, the eight weeks that took place the intermittent teaching unit) they also performed two Physical Education sessions, but without using activity wristbands or other behavior modification strategies. Before and after the intervention, as well as at the end of the follow-up period (six weeks), students’ physical activity practice mediators and physical activity levels were measured by validated questionnaires.ResultsThe Multilevel Linear Model results showed that the IG students statistically significantly improved cognitive and procedural autonomy support from pre- to post-intervention (p

Published
2023
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30. Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS eventsResearch in context

Author

Javier Martínez-Sanz, Jorge Díaz-Álvarez, Marta Rosas, Raquel Ron, José Antonio Iribarren, Enrique Bernal, Félix Gutiérrez, Andrés Ruiz Sancho, Noemi Cabello, Julián Olalla, Santiago Moreno, Sergio Serrano-Villar, Inma Jarrín, David Dalmau, M. Luisa Navarro, M. Isabel González, Federico Garcia, Eva Poveda, Jose Antonio Iribarren, Rafael Rubio, Francesc Vidal, Juan Berenguer, Juan González, M. Ángeles Muñoz-Fernández, Inmaculada Jarrín, Cristina Moreno, Marta Rava, Rebeca Izquierdo, Elba Mauleón, Joaquín Portilla, Irene Portilla, Esperanza Merino, Gema García, Iván Agea, José Sánchez-Payá, Juan Carlos Rodríguez, Livia Giner, Sergio Reus, Vicente Boix, Diego Torrus, Verónica Pérez, Julia Portilla, Juan Luís Gómez, Jehovana Hernández, Ana López Lirola, Dácil García, Felicitas Díaz-Flores, M. Mar Alonso, Ricardo Pelazas, M. Remedios Alemán, Víctor Asensi, María Eugenia Rivas Carmenado, Tomás Suarez-Zarracina, Federico Pulido, Otilia Bisbal, M. Asunción Hernando, David Rial, María de Lagarde, Octavio Arce, Adriana Pinto, Laura Bermejo, Mireia Santacreu, Roser Navarro, Candela Gonzalez, M. José Aramburu, Xabier Camino, Miguel Ángel von Wichmann, Miguel Ángel Goenaga, M. Jesús Bustinduy, Harkaitz Azkune, Maialen Ibarguren, Xabier Kortajarena, Ignacio Álvarez-Rodriguez, Leire Gil, Lourdes Martínez, Catalina Robledano, Mar Masiá, Sergio Padilla, Araceli Adsuar, Rafael Pascual, Marta Fernández, Antonio Galiana, José Alberto García, Xavier Barber, Vanessa Agullo, Javier Garcia Abellán, Reyes Pascual, Guillermo Telenti, Lucia Guillén, Ángela Botella, Roberto Muga, Arantza Sanvisens, Daniel Fuster, Isabel Gutierrez, Juan Carlos López, Margarita Ramírez, Belén Padilla, Paloma Gijón, Teresa Aldamiz-Echevarría, Francisco Tejerina, Cristina Diez, Leire Pérez, Chiara Fanciulli, Saray Corral, Anna Martí, Joaquín Peraire, Consuelo Viladés, Montserrat Vargas, Montserrat Olona, Anna Rull, Verónica Alba, Elena Yeregui, Jenifer Masip, Graciano García-Pardo, Frederic Gómez Bertomeu, Sonia Espineira, Marta Montero, Sandra Cuéllar, Marino Blanes, María Tasias, Eva Calabuig, Miguel Salavert, Juan Fernández, Inmaculada Segarra, Juan González-García, Ana Delgado, Francisco Arnalich, José Ramón Arribas, Jose Ignacio Bernardino, Juan Miguel Castro, Luis Escosa, Pedro Herranz, Victor Hontañón, Silvia García-Bujalance, Milagros García, Alicia González-Baeza, M. Luz Martín-Carbonero, Mario Mayoral, M. Jose Mellado, Rafael Esteban, Rocío Montejano, M. Luisa Montes, Victoria Moreno, Ignacio Pérez-Valero, Berta Rodés, Guadalupe Rúa, Talía Sainz, Elena Sendagorta, Eulalia Valencia, Carmen Busca, Joanna Cano, Julen Cardiñanos, Rosa de Miguel, Jose Ramón Blanco, Laura Pérez-Martínez, José Antonio Oteo, Valvanera Ibarra, Luis Metola, Mercedes Sanz, Piedad Arazo, Gloria Sampériz, Marina Martinez, Angels Jaén, Montse Sanmartí, Mireia Cairó, Javier Martinez-Lacasa, Pablo Velli, Roser Font, Mariona Xercavins, Noemí Alonso, Francesco Aiello, María Rivero, Beatriz Piérola, Maider Goikoetxea, María Gracia, Carlos Ibero, Estela Moreno, Jesús Repáraz, Gemma Navarro, Manel Cervantes Garcia, Sonia Calzado Isbert, Marta Navarro Vilasaro, Belen Lopez Garcia, Ignacio de los Santos, Alejandro de los Santos, Jesús Sanz, Lucio García-Fraile, Enrique Martín, Ildefonso Sánchez-Cerrillo, Marta Calvet, Ana Barrios, Azucena Bautista, Carmen Sáez, Marianela Ciudad, Ángela Gutiérrez, Santos del Campo, José Luis Casado, Fernando Dronda, Ana Moreno, M. Jesús Pérez, Sergio Serrano, Ma Jesús Vivancos, Alejandro Vallejo, Matilde Sanchez, Jose Antonio Pérez-Molina, José Manuel Hermida, Antonia Alcaraz, Joaquín Bravo, Ángeles Muñoz, Cristina Tomás, Mónica Martínez, M. Carmen Villalba, Federico García, Clara Martínez, José Hernández, Leopoldo Muñoz Medina, Marta Álvarez, Natalia Chueca, David Vinuesa, Adolfo de Salazar, Ana Fuentes, Emilio Guirao, Laura Viñuela, Andrés Ruiz-Sancho, Francisco Anguita, Jorge Del Romero, Montserrat Raposo, Carmen Rodríguez, Teresa Puerta, Juan Carlos Carrió, Mar Vera, Juan Ballesteros, Oskar Ayerdi, Begoña Baza, Eva Orviz, Antonio Antela, Elena Losada, Melchor Riera, María Peñaranda, M. Angels Ribas, Antoni A. Campins, Mercedes Garcia-Gazalla, Francisco J. Fanjul, Javier Murillas, Francisco Homar, Helem H. Vilchez, Luisa Martin, Antoni Payeras, Jesús Santos, María López, Crisitina Gómez, Isabel Viciana, Rosario Palacios, Luis Fernando López-Cortés, Nuria Espinosa, Cristina Roca, Silvia Llaves, Juan Manuel Tiraboschi, Arkaitz Imaz, Ana Karina Silva, María Saumoy, Sofía Catalina Scévola, Adrián Curran, Vicenç Falcó, Jordi Navarro, Joaquin Burgos, Paula Suanzes, Jorge García, Vicente Descalzo, Patricia Álvarez, Bibiana Planas, Marta Sanchiz, Lucía Rodríguez, M José Sánchez, Javier Pérez, Alfonso del Arco, Javier de la Torre, José Luis Prada, Onofre Juan Martínez, Lorena Martinez, Francisco Jesús Vera, Josefina García, Begoña Alcaraz, Antonio Jesús Sánchez Guirao, Alvaro Mena, Angeles Castro, Berta Pernas, Pilar Vázquez, Soledad López, Sofía Ibarra, Guillermo García, Josu Mirena, Oscar Luis Ferrero, Josefina López, M. Mar Cámara, Mireia de la Peña, Miriam Lopez, Iñigo Lopez, Itxaso Lombide, Victor Polo, Joana de Miguel, Carlos Galera, Marian Fernández, Helena Albendin, Antonia Castillo, Asunción Iborra, Antonio Moreno, M. Angustias Merlos, Asunción Vidal, Concha Amador, Francisco Pasquau, Concepcion Gil, Jose Tomás Algado, Inés Suarez-García, Eduardo Malmierca, Patricia González-Ruano, M. Pilar Ruiz, José Francisco Pascual, Elena Sáez, Luz Balsalobre, M. Villa López, Mohamed Omar, Carmen Herrero, M. Amparo Gómez, Miguel Alberto de Zarraga, Desiré Pérez, Vicente Estrada, Nieves Sanz, Noemí Cabello, Jorge Vergas García, Maria Jose Núñez, Iñigo Sagastagoitia, Miguel Górgolas, Alfonso Cabello, Beatriz Álvarez, Laura Prieto, Irene Carrillo, José Sanz, Alberto Arranz, Cristina Hernández, María Novella, M. José Galindo, Ana Ferrer, Antonio Rivero Román, Inma Ruíz, Antonio Rivero Juárez, Pedro López, Isabel Machuca, Mario Frias, Ángela Camacho, Ignacio Pérez, Diana Corona, Miguel Cervero, Rafael Torres, Juan Antonio Pineda, Pilar Rincón, Juan Macías, Luis Miguel Real, Anais Corma, Alejandro Gonzalez-Serna, Alexandre Pérez, Luis Morano, Celia Miralles, Antonio Ocampo, Guillermo Pousada, Lucía Patiño, Carlos Dueñas, Sara Gutiérrez, Elena Tapia, Cristina Novoa, Xjoylin Egües, and Pablo Telleria

Subjects
HIV, Non-AIDS events, Neoplasia, Cardiovascular event, CD4/CD8 ratio, Medicine, Medicine (General), R5-920
Abstract

Summary: Background: While a low CD4/CD8 ratio during HIV treatment correlates with immunosenescence, its value in identifying patients at an increased risk for clinical events remains unclear. Methods: We analyzed data from the CoRIS cohort to determine whether CD4 count, CD8 count, and CD4/CD8 ratio at year two of antiretroviral therapy (ART) could predict the risk of serious non-AIDS events (SNAEs) during the next five years. These included major adverse cardiovascular events, non-AIDS-defining malignancies, and non-accidental deaths. We used pooled logistic regression with inverse probability weighting to estimate the survival curves and cumulative risk of clinical events. Findings: The study included 4625 participants, 83% male, of whom 200 (4.3%) experienced an SNAE during the follow-up period. A CD4/CD8 ratio

Published
2023
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31. Síndrome de Contarini: ¿una entidad olvidada?

Author

Elena Viciana-Martín, Sindy Cedeño-Berenice, and José D. García-Jiménez

Subjects
Síndrome de Contarini. Derrame pleural bilateral., Diseases of the respiratory system, RC705-779
Abstract

El síndrome de Contarini es una presentación infrecuente de derrame pleural bilateral en la cual el líquido pleural en cada hemitórax presenta diferentes características, y puede explicarse por diferentes causas. Hay escasa literatura al respecto, por lo que presentamos un caso de derrame pleural bilateral que sería compatible con dicho síndrome.

Published
2023
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32. Validity of activity wristbands for estimating daily physical activity in primary schoolchildren under free-living conditions: School-Fit study

Author

Daniel Mayorga-Vega, Carolina Casado-Robles, Santiago Guijarro-Romero, and Jesús Viciana

Subjects
consumer-wearable activity trackers, wrist-worn wearables, fitness trackers, agreement, steps, moderate-to-vigorous physical activity, Public aspects of medicine, RA1-1270
Abstract

IntroductionThe use of activity wristbands to monitor and promote schoolchildren's physical activity (PA) is increasingly widespread. However, their validity has not been sufficiently studied, especially among primary schoolchildren. Consequently, the main purpose was to examine the validity of the daily steps and moderate-to-vigorous PA (MVPA) scores estimated by the activity wristbands Fitbit Ace 2, Garmin Vivofit Jr 2, and the Xiaomi Mi Band 5 in primary schoolchildren under free-living conditions.Materials and methodsAn initial sample of 67 schoolchildren (final sample = 62; 50% females), aged 9–12 years old (mean = 10.4 ± 1.0 years), participated in the present study. Each participant wore three activity wristbands (Fitbit Ace 2, Garmin Vivofit Jr 2, and Xiaomi Mi Band 5) on his/her non-dominant wrist and a research-grade accelerometer (ActiGraph wGT3X-BT) on his/her hip as the reference standard (number of steps and time in MVPA) during the waking time of one day.ResultsResults showed that the validity of the daily step scores estimated by the Garmin Vivofit Jr 2 and Xiaomi Mi Band 5 were good and acceptable (e.g., MAPE = 9.6/11.3%, and lower 95% IC of ICC = 0.87/0.73), respectively, as well as correctly classified schoolchildren as meeting or not meeting the daily 10,000/12,000-step-based recommendations, obtaining excellent/good and good/acceptable results (e.g., Garmin Vivofit Jr 2, k = 0.75/0.62; Xiaomi Mi Band 5, k = 0.73/0.53), respectively. However, the Fitbit Ace 2 did not show an acceptable validity (e.g., daily steps: MAPE = 21.1%, and lower 95% IC of ICC = 0.00; step-based recommendations: k = 0.48/0.36). None of the three activity wristbands showed an adequate validity for estimating daily MVPA (e.g., MAPE = 36.6–90.3%, and lower 95% IC of ICC = 0.00–0.41) and the validity for the MVPA-based recommendation tended to be considerably lower (e.g., k = −0.03–0.54).ConclusionsThe activity wristband Garmin Vivofit Jr 2 obtained the best validity for monitoring primary schoolchildren's daily steps, offering a feasible alternative to the research-grade accelerometers. Furthermore, this activity wristband could be used during PA promotion programs to provide accurate feedback to primary schoolchildren to ensure their accomplishment with the PA recommendations.

Published
2023
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39. SHOC2 complex-driven RAF dimerization selectively contributes to ERK pathway dynamics

Author

del Río, Isabel Boned, Young, Lucy C, Sari, Sibel, Jones, Greg G, Ringham-Terry, Benjamin, Hartig, Nicole, Rejnowicz, Ewa, Lei, Winnie, Bhamra, Amandeep, Surinova, Silvia, and Rodriguez-Viciana, Pablo

Subjects
Biochemistry and Cell Biology, Biological Sciences, Cancer, 1.1 Normal biological development and functioning, Underpinning research, CRISPR-Associated Protein 9, CRISPR-Cas Systems, Cell Line, Tumor, Gene Editing, Gene Knockout Techniques, Humans, Intracellular Signaling Peptides and Proteins, MAP Kinase Signaling System, Phosphorylation, Protein Multimerization, raf Kinases, ras Proteins, SHOC2, RAF, MRAS, RAS, ERK
Abstract

Despite the crucial role of RAF kinases in cell signaling and disease, we still lack a complete understanding of their regulation. Heterodimerization of RAF kinases as well as dephosphorylation of a conserved "S259" inhibitory site are important steps for RAF activation but the precise mechanisms and dynamics remain unclear. A ternary complex comprised of SHOC2, MRAS, and PP1 (SHOC2 complex) functions as a RAF S259 holophosphatase and gain-of-function mutations in SHOC2, MRAS, and PP1 that promote complex formation are found in Noonan syndrome. Here we show that SHOC2 complex-mediated S259 RAF dephosphorylation is critically required for growth factor-induced RAF heterodimerization as well as for MEK dissociation from BRAF. We also uncover SHOC2-independent mechanisms of RAF and ERK pathway activation that rely on N-region phosphorylation of CRAF. In DLD-1 cells stimulated with EGF, SHOC2 function is essential for a rapid transient phase of ERK activation, but is not required for a slow, sustained phase that is instead driven by palmitoylated H/N-RAS proteins and CRAF. Whereas redundant SHOC2-dependent and -independent mechanisms of RAF and ERK activation make SHOC2 dispensable for proliferation in 2D, KRAS mutant cells preferentially rely on SHOC2 for ERK signaling under anchorage-independent conditions. Our study highlights a context-dependent contribution of SHOC2 to ERK pathway dynamics that is preferentially engaged by KRAS oncogenic signaling and provides a biochemical framework for selective ERK pathway inhibition by targeting the SHOC2 holophosphatase.

Published
2019

40. SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers

Author

Jones, Greg G, del Río, Isabel Boned, Sari, Sibel, Sekerim, Aysen, Young, Lucy C, Hartig, Nicole, Areso Zubiaur, Itziar, El-Bahrawy, Mona A, Hynds, Rob E, Lei, Winnie, Molina-Arcas, Miriam, Downward, Julian, and Rodriguez-Viciana, Pablo

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Biological Sciences, Cancer, Lung, Lung Cancer, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Animals, Apoptosis, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Drug Resistance, Neoplasm, Female, HEK293 Cells, Humans, Intracellular Signaling Peptides and Proteins, Lung Neoplasms, MAP Kinase Signaling System, Male, Mice, Knockout, Mice, Nude, Mutation, Neoplasm Transplantation, Protein Kinase Inhibitors, Protein Multimerization, raf Kinases, ras Proteins
Abstract

Targeted inhibition of the ERK-MAPK pathway, upregulated in a majority of human cancers, has been hindered in the clinic by drug resistance and toxicity. The MRAS-SHOC2-PP1 (SHOC2 phosphatase) complex plays a key role in RAF-ERK pathway activation by dephosphorylating a critical inhibitory site on RAF kinases. Here we show that genetic inhibition of SHOC2 suppresses tumorigenic growth in a subset of KRAS-mutant NSCLC cell lines and prominently inhibits tumour development in autochthonous murine KRAS-driven lung cancer models. On the other hand, systemic SHOC2 ablation in adult mice is relatively well tolerated. Furthermore, we show that SHOC2 deletion selectively sensitizes KRAS- and EGFR-mutant NSCLC cells to MEK inhibitors. Mechanistically, SHOC2 deletion prevents MEKi-induced RAF dimerization, leading to more potent and durable ERK pathway suppression that promotes BIM-dependent apoptosis. These results present a rationale for the generation of SHOC2 phosphatase targeted therapies, both as a monotherapy and to widen the therapeutic index of MEK inhibitors.

Published
2019

41. Temporal changes in the genotypes of Paslahepevirus balayani in southern Spain and their possible link with changes in pig trade imports

Author

Pedro Lopez-Lopez, Mario Frias, Ana Belén Perez-Jimenez, Carolina Freyre-Carrillo, Juan A. Pineda, Ana Fuentes, Juan Carlos Alados, Encarnación Ramirez-Arellano, Isabel Viciana, Diana Corona-Mata, Javier Caballero-Gomez, Ignacio Garcia-Bocanegra, María A. Risalde, Antonio Rivero-Juarez, and Antonio Rivero

Subjects
Hepatitis E, Pig, One health, Genotype, Acute hepatitis, Epidemiology, Medicine (General), R5-920
Abstract

Introduction: Paslahepevirus balayani (HEV) is an endemic zoonotic disease ranked as a major cause of acute hepatitis in Europe. Most infections occurring in Europe are due to the endemic several subtypes of genotype 3, through the consumption of raw or undercooked pork, observing a genotype geographical distribution pattern among countries Because of global changes in the pig and pork trading markets, subtype distribution might vary. We aimed to evaluate the temporal distribution of HEV genotypes in patients from southern Spain with acute hepatitis to determine whether these changes were related to the pig import trade during the study period between 2018 and 2022. Methods: Prospective longitudinal study including patients with acute hepatitis from southern Spain between 2018 and 2022. HEV RNA and antibodies was tested in all patients. In patients with detectable HEV RNA, genotype was obtained. To determine the number of imported pigs and their origins, we checked the official data from the Spanish statistics on international trade of Spanish Minister of Industry during by country of origin during the same study period. Results: A total of 659 patients with acute hepatitis were included in the study. Among them, 162 (24.5%) had at least one marker (IgM or RNA) of acute HEV infection. Among the 71 patients with detectable viral RNA, genotypes could be obtained for 58 (81.6%). The most prevalent HEV genotype was 3f (n = 48; 78.6%), showing a decreasing prevalence of over time, from 100% in 2018 to 70.6% in 2022. Since 2021, the emergence of other genotypes has been determined. A significant increase in the number of animals imported was observed since the beginning of the study. Denmark experienced a significant rise, from 0.03% in 2018 of total imports to 10.4% in 2022. Conclusions: HEV molecular diversity is changing in Spain, could be linked to changes in fattening pig import origin.

Published
2023
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42. Effects of first-line antiretroviral therapy on the CD4/CD8 ratio and CD8 cell counts in CoRIS: a prospective multicentre cohort study

Author

Jarrin, Inmaculada, Moreno, Santiago, Alejos, Belén, Muñoz-Fernández, MÁngeles, Consuegra, Irene, Merino, Esperanza, García, Gema, Lirola, Ana López, García, Dácil, Asensi, Víctor, Valle, Eulalia, Rubio, Rafael, Pulido, Federico, Iribarren, José Antonio, Arrizabalaga, Julio, Gutiérrez, Félix, Masiá, Mar, Muga, Roberto, Sanvisens, Arantza, Berenguer, Juan, Vidal, Francesc, Montero, Marta, Blanco, José Ramón, López Bernarlo de Quirós, Juan Carlos, González-Garcia, Juan, Peraire, Joaquín, Arazo, Piedad, López-Aldeguer, José, Dalmau, David, Arnalich, Francisco, Rivero, Maria, Oteo, José Antonio, Sampériz, Gloria, Amengual, María José, Jaén, Angels, de los Santos, Ignacio, Repáraz, Jesús, Navarro, Gemma, Bernal, Enrique, Sanz, Jesús, Viciana, Pompeyo, García, Federico, Casado, José Luis, Del Romero, Jorge, Cano, Alfredo, Antela, Antonio, Quero, José Hernández, Riera, Melchor, Raposo, Montserrat, Santos, Jesús, Losada, Elena, Daniel, Podzamczer, Peñaranda, María, Ayerbe, Cristina Gómez, Espinosa, Nuria, Olalla, Julián, Imaz, Arkaitz, Martínez, Onofre, Curran, Adrian, Castro, Ángeles, Pérez Stachowski, Javier, Muñoz, Josefa, Vera, Francisco Jesús, Galera, Carlos, Pernas, Berta, Amador, Concha, Zuriñe, Miren, Albendin, Helena, Suárez-García, Inés, Pasquau, Francisco, Omar, Mohamed, Malmierca, Eduardo, de Zarraga, Miguel Alberto, Gómez Vidal, María Amparo, Estrada, Vicente, Górgolas, Miguel, Sanz, José, Téllez, María Jesús, Galindo, María José, Cabello, Alfonso, Rivero, Antonio, Arranz, Alberto, Cervero, Miguel, Vilalta, Ramón, Pineda, Juan A, Rivero-Juárez, Antonio, Torres, Rafael, Poveda, Eva, Rincón, Pilar, Pérez, Alexandre, Moreno, Cristina, Portilla, Irene, Díaz-Flores, Felicitas, Rivas, María E, Bisbal, Otilia, Aramburu, María J, Padilla, Sergio, Fuster, Daniel, Gutiérrez, Isabel, Viladés, Consuelo, Blanes, Marino, Arribas, José Ramón, Ibarra, Valvanera, Sanmartí, Montse, de Alda, María Ruiz, Cervantes, Manel, Salas, Ana, Dronda, Fernando, Alcaraz, Antonia, Muñoz, Leopoldo, Rodríguez, Carmen, Ribas, María Angels, Viciana, Isabel, López-Cortés, Luis, Tiraboschi, Juan, del Arco, Alfonso, Martínez, Lorena, Mena, Álvaro, Mirena, Josu, Pérez, Aurora, Ena, Javier, González-Ruano, Patricia, Vergas, Jorge, Álvarez, Beatriz, Hernández, Cristina, Ferrer, Ana, López, Pedro, Macías, Juan, Crespo, Manuel, Navarro, Maria Luisa, Iniesta, Carlos, Agea, Iván, Gómez, Juan Luis, Suárez-Zarracina, Tomás, Hernando, Asunción, Camino, Xabier, Robledano, Catalina, Ramírez, Margarita, Veloso, Sergio, Tasias, María, Bernardino, Jose Ignacio, Metola, Luis, Cairó, Mireia, de León Cano, María Teresa, Calzado, Sonia, Sarria, Cristina, Moreno, Ana, Bravo, Joaquín, Alvarez, Marta, Puerta, Teresa, Campins, Antoni A, Palacios, Rosario, Silva, Ana, de la Torre, Javier, García, Josefina, Ibarra, Sofía, Iborra, Asunción, Benito, Concha, Martín, Dolores, Pérez-Somarriba, Juncal, Prieto, Laura, Novella, María, Machuca, Isabel, Merchante, Nicolás, Morano, Luis, González, Maria Isabel, García, Luis NM, Portilla, Joaquín, Alonso, María del Mar, Pérez, Laura, Domínguez, Lourdes, Rodríguez-Arrondo, Francisco, Colomé, Joan Gregori, Padilla, Belén, Vargas, Montserrat, Castro, Iván, Castro, Juan Miguel, Sanz, Mercedes, Martinez-Lacasa, Javier, Pierola, Beatriz, Navarro, Marta, Garcia-Fraile, Lucio, Pérez-Elias, Maria Jesús, Muñoz, Ángeles, Chueca, Natalia, Carrió, Juan Carlos, Vidal, Carmen, Pérez, Carmen, Saumoy, María, Prada, José Luis, Alcaraz, Begoña, Ferrero, Oscar, Moreno, Antonio, Fenoll, Vicenta, Ruiz, Mª Pilar, Frias, Mario, Real, Luis Miguel, Miralles, Celia, Garcia, Federico, Sanz, Nieves, Sánchez-Payá, José, Pelazas, Ricardo, Rial, David, von Wichman, Miguel Ángel, Adsuar, Araceli, Gijón, Paloma, Olona, Montserrat, Calabuig, Eva, Delgado, Ana, Pérez-Martínez, Laura, Velli, Pablo, Martín-Gayo, Enrique, Gutiérrez, Carolina, Alcaraz, Maria José, Vinuesa, David, Vera, Mar, Fanjul, Francisco, Gonzalez-Domenec, Carmen, Prieto, Paula, de las Lomas, José N García, Jimeno, Amaya, López, Josefina, Merlos, Maria, Gil, Concepción, Camacho, Angela, Corma, Anais, Ocampo, Antonio, Rava, Marta, Rodríguez, Juan Carlos, Hernández, Jehovana, Bermejo, Laura, Pascual, Lidia, Pascual, Rafael, Aldamiz-Echevarría, Teresa, Rull, Anna, Cuéllar, Sandra, Escosa, Luis, Font, Roser, Madrid, Nadia, del Carmen Villalba, Maria, Martinez-Montes, Clara, Ballesteros, Juan, Murillas, Javier, Cámara, María Mar, Vidal, Asunción, Algado, José Tomas, Fernández, Marta, Pousada, Guillermo, Iribarren, Jose Antonio, Gimeno, Lina, Alemán, María Remedios, Santacreu, Mireia, Goenaga, Miguel Ángel, Tejerina, Francisco, Rodríguez-Gallego, Esther, Salavert, Miguel, Herranz, Pedro, Martinez, Marina, del Campo, Santos, Guerrero, Carlos, Ayerdi, Oskar, Homar, Francisco, de la Peña, Mireia, Meca, Marisa, Díez, Marcos, Azkune, Harkaitz, Barber, Xavier, Balsalobre, Pascual, Castellanos, Alfonso Javier, García-Bujalance, Silvia, Vivancos, Maria Jesús, Fuentes, Ana, Martin, Maria Luisa, Lopez, Iñigo, Vilchez, Helem, Lopez, Miriam, Carreres, Melissa, Ibarguren, Maialen, Agullo, Vanessa, Diez, Cristina, López-Dupla, Miguel, García, Milagros, Umerez, Maitane, Martínez-Sanz, Javier, Payeras, Antoni, Reus, Sergio, Lizardi, Aitziber, Garcia, Javier, Pérez, Leire, González-Baeza, Alicia, Anxa, Usua, González, Juan, Boix, Vicente, Kortajarena, Xabier, Pascual, Reyes, Fanciulli, Chiara, Martín-Carbonero, Maria Luz, Mellado, Maria José, Micán, Rafael, Montejano, Rocio, Montes, María Luisa, Moreno, Victoria, Pérez-Valero, Ignacio, Rúa, Guadalupe, Rodés, Berta, Sainz, Talia, Sendagorta, Elena, Stella, Natalia, Valencia, Eulalia, Velasco, Tamara, Muñoz-Fernández, María Ángeles, Torrús, Diego, Carmona, María Pilar, Roca, María, Mayoral, Mario, Vallejo, Alejandro, Serrano-Villar, Sergio, Ron, Raquel, Talavera-Rodríguez, Alba, Fernández-Felix, Borja M, Herrera, Sabina, Muriel, Alfonso, de Zárraga, Miguel Alberto, and Vivancos, María J

Published
2020
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45. Physical education-based intervention with activity wristbands to promote students' weekly physical activity.

Author

Guijarro-Romero, Santiago, Mayorga-Vega, Daniel, Casado-Robles, Carolina, and Viciana, Jesús

Subjects
PHYSICAL education, HIGH school students, PHYSICAL activity, EDUCATIONAL counseling, STUDENTS
Abstract

The purpose was to examine the effect of an intermittent teaching unit based on the use of an activity wristband combined with other behavior modification techniques on secondary students' weekly objectively-measured physical activity (PA). 176 secondary students (12-16 years) were cluster-randomly assigned into the activity wristband (AWG) and control groups. The AWG performed an eight-week intermittent teaching unit (last 15 min of each session) twice a week. The teaching unit consisted in the following strategies: activity wristband (24 h), adaptative step goals, and educational counseling, among others. Results showed that the AWG students improved activity wristband-measured weekly steps from baseline to the last week of the intervention (p < 0.001). Furthermore, the percentage of AWG students that did at least an average of 10,000 steps per day increased (p = 0.026). The studied intermittent teaching unit increased studentsʼ weekly PA, and the proportion of students that achieved the PA. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Opiniones de los participantes en una intervención para el fomento de la actividad física en el contexto escolar: Estudio Fit-Person.

Author

López-Fernández, Iván, Mayorga-Vega, Daniel, Guijarro-Romero, Santiago, and Viciana, Jesús

Subjects
BEHAVIOR modification, SCHOOL children, PHYSICAL activity, PHYSICAL education, HOME environment
Abstract

Copyright of Retos: Nuevas Perspectivas de Educación Física, Deporte y Recreación is the property of Federacion Espanola de Asociaciones de Docentes de Educacion Fisica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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47. Evaluation of a Multi-speaker System for Socially Assistive HRI in Real Scenarios

Author

Martínez-Colón, Antonio, Viciana-Abad, Raquel, Perez-Lorenzo, Jose Manuel, Evers, Christine, Naylor, Patrick A., Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Bergasa, Luis M., editor, Ocaña, Manuel, editor, Barea, Rafael, editor, López-Guillén, Elena, editor, and Revenga, Pedro, editor

Published
2021
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