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This study investigates the sensitivity of the one-way nested PRECIS regional climate model (RCM) to domain size for the Caribbean region. Simulated regional rainfall patterns from experiments using three domains with horizontal resolution of 50 km are compared with ERA reanalysis and observed datasets to determine if there is an optimal RCM configuration with respect to domain size and the ability to reproduce important observed climate features in the Caribbean. Results are presented for the early wet season (May-July) and late wet season (August-October). There is a relative insensitivity to domain size for simulating some important features of the regional circulation and key rainfall characteristics e.g. the Caribbean low level jet and the mid summer drought (MSD). The downscaled precipitation has a systematically negative precipitation bias, even when the domain was extended to the African coast to better represent circulation associated with easterly waves and tropical cyclones. The implications for optimizing modelling efforts within resource-limited regions like the Caribbean are discussed especially in the context of the region's participation in global initiatives such as CORDEX. [ABSTRACT FROM AUTHOR]