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Thyroid nodules are usually explored non-invasively by ultrasonography followed by an invasive cytopunction in case of suspected cancer. Echogenicity of the thyroid nodule is a key parameter to differentiate benign and malignant nodules but its visual determination lacks reproducibility. The objective of this r.tudy was to define and evaluate a standardized measurement cf thvroid natures' echogenicity. In this monocentric study, ultrasound data .(2D recorded images, echogenicity and EU-TIRADS (European Thyroid Imaging Reporting And Data System) score determined visually by an experienced physician) and cytological results of cytopunctions performed between June 2016 and January 2019 were retrieved retrospectively. A manual segmentation on the 20 recorded images of the nodules, the healthy thyroid and the cervical muscles was performed to measure the nodules' echogenicity normalized by the healthy thyroid (Nt) and the muscles (Nm). Spearman's correlations were used to compare the parameters and a comparative analysis of diagnostic performance by ROC (Receiving Operator Characteristic) curves by using cytological Bethesda results as reference. 201 patients (224 nodules) with thyroid cytopunctions were included and analyzed. Concerning the Spearman's correlations, the measured parameters were moderately correlated to the EU-TIRADS (maximal p=-0,60, p