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23 results on '"Viaggi, Cristina"'

1. Melanocortin receptor 4 as a new target in melanoma therapy: Anticancer activity of the inhibitor ML00253764 alone and in association with B-raf inhibitor vemurafenib

Author

Orlandi, Paola, Banchi, Marta, Vaglini, Francesca, Carli, Marco, Aringhieri, Stefano, Bandini, Arianna, Pardini, Carla, Viaggi, Cristina, Lai, Michele, Alì, Greta, Ottani, Alessandra, Vandini, Eleonora, Guidi, Patrizia, Bernardeschi, Margherita, La Rocca, Veronica, Francia, Giulio, Fontanini, Gabriella, Pistello, Mauro, Frenzilli, Giada, Giuliani, Daniela, Scarselli, Marco, and Bocci, Guido

Published
2024
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2. Glial cells are affected more than interneurons by the loss of Engrailed 2 gene in the mouse cerebellum.

Author

Lazzarini, Giulia, Gatta, Alessandra, Miragliotta, Vincenzo, Vaglini, Francesca, Viaggi, Cristina, and Pirone, Andrea

Subjects
NEUROGLIA, CEREBELLUM, INTERNEURONS, AUTISM spectrum disorders, VOXEL-based morphometry
Abstract

Glial cells play a pivotal role in the inflammatory processes, which are common features of several neurodevelopmental and neurodegenerative disorders. Their major role in modulating neuroinflammation underscores their significance in these conditions. Engrailed‐2 knockout mice (En2−/−) are considered a valuable model for autism spectrum disorder (ASD) due to their distinctive neuroanatomical and behavioral traits. Given the higher prevalence of ASD in males, our objective was to investigate glial and interneuron alterations in the cerebellum of En2−/− mice compared with wild‐type (WT) mice in both sexes. We employed immunohistochemical analysis to assess cell density for all cell types studied and analyzed the area (A) and shape factor (SF) of microglia cell bodies. Our findings revealed the following: (a) In WT mice, the density of microglia and astrocytes was higher in females than in males, while interneuron density was lower in females. Notably, in En2‐mutant mice, these differences between males and females were not present. (b) In both male and female En2−/− mice, astrocyte density exceeded that in WT mice, with microglia density being greater only in females. (c) In WT females, microglia cell bodies exhibited a larger area and a lower shape factor compared to WT males. Remarkably, the En2 mutation did not appear to influence these sex‐related differences. (d) In both male and female En2−/− mice, we observed a consistent pattern: microglia cell bodies displayed a larger area and a smaller shape factor. Given the ongoing debate surrounding the roles of glia and sex‐related factors in ASD, our observations provide valuable insights into understanding how an ASD‐associated gene En2 affects specific cell types in the cerebellum. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Melanocortin receptor 4 as a new target in melanoma therapy: Anticancer activity of the inhibitor ML00253764 alone and in association with B-raf inhibitor vemurafenib

Author

Orlandi, Paola, primary, Banchi, Marta, additional, Vaglini, Francesca, additional, Carli, Marco, additional, Aringhieri, Stefano, additional, Bandini, Arianna, additional, Pardini, Carla, additional, Viaggi, Cristina, additional, Lai, Michele, additional, Alì, Greta, additional, Ottani, Alessandra, additional, Vandini, Eleonora, additional, Guidi, Patrizia, additional, Bernardeschi, Margherita, additional, La Rocca, Veronica, additional, Francia, Giulio, additional, Fontanini, Gabriella, additional, Pistello, Mauro, additional, Frenzilli, Giada, additional, Giuliani, Daniela, additional, Scarselli, Marco, additional, and Bocci, Guido, additional

Published
2023
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5. Pharmacological Strategies for Bipolar Disorders in Acute Phases and Chronic Management with a Special Focus on Lithium, Valproic Acid, and Atypical Antipsychotics

Author

Scarselli, Marco, primary, Carli, Marco, additional, Weiss, Francesco, additional, Grenno, Giovanna, additional, Ponzini, Sergio, additional, Kolachalam, Shivakumar, additional, Vaglini, Francesca, additional, Viaggi, Cristina, additional, Pardini, Carla, additional, Tidona, Simone, additional, Longoni, Biancamaria, additional, and Maggio, Roberto, additional

Published
2023
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12. Grafted Neural Precursors Integrate Into Mouse Striatum, Differentiate and Promote Recovery of Function Through Release of Erythropoietin in MPTP-Treated Mice

Author

Stephana Carelli1,, Giallongo, Toniella, Viaggi, Cristina, Gombalova, Zuzana, Latorre, Elisa, Mazza, Massimiliano, Vaglini, Francesca, Giulio, Anna Maria Di, and Gorio, Alfredo

Subjects
Male, Tyrosine 3-Monooxygenase, adult neural stem cells, Cell- and Tissue-Based Therapy, regenerative medicine, Mice, Transgenic, Nerve Tissue Proteins, Choline O-Acetyltransferase, lcsh:RC321-571, Mice, Neural Stem Cells, Antigens, Neoplasm, otorhinolaryngologic diseases, Animals, Muscle Strength, Antigens, Erythropoietin, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, MPTP, gamma-Aminobutyric Acid, Movement Disorders, MPTP Poisoning, Recovery of Function, Corpus Striatum, Mice, Inbred C57BL, Disease Models, Animal, stomatognathic diseases, Parkinson’s disease, Original Article, Proteoglycans, cell therapy
Abstract

Erythropoietin-releasing neural precursor cells (Er-NPCs) are a subclass of subventricular zone-derived neural progenitors, capable of surviving for 6 hr after death of donor. They present higher neural differentiation. Here, Er-NPCs were studied in animal model of Parkinson’s disease. Dopaminergic degeneration was caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intraperitoneal administration in C57BL/6 mice. The loss of function was evaluated by specific behavioral tests. Er-NPCs (2.5 × 10 5 ) expressing the green fluorescent protein were administered by stereotaxic injection unilaterally in the left striatum. At the end of observational research period (2 weeks), most of the transplanted Er-NPCs were located in the striatum, while several had migrated ventrally and caudally from the injection site, up to ipsilateral and contralateral substantia nigra. Most of transplanted cells had differentiated into dopaminergic, cholinergic, or GABAergic neurons. Er-NPCs administration also promoted a rapid functional improvement that was already evident at the third day after cells administration. This was accompanied by enhanced survival of nigral neurons. These effects were likely promoted by Er-NPCs-released erythropoietin (EPO), since the injection of Er-NPCs in association with anti-EPO or anti-EPOR antibodies had completely neutralized the recovery of function. In addition, intrastriatal administration of recombinant EPO mimics the effects of Er-NPCs. We suggest that Er-NPCs, and cells with similar properties, may represent good candidates for cellular therapy in neurodegenerative disorders of this kind.

Published
2016

14. Fluorescent light induces neurodegeneration in the rodent nigrostriatal system but near infrared LED light does not

Author

Romeo, Stefania, primary, Vitale, Flora, additional, Viaggi, Cristina, additional, di Marco, Stefano, additional, Aloisi, Gabriella, additional, Fasciani, Irene, additional, Pardini, Carla, additional, Pietrantoni, Ilaria, additional, Di Paolo, Mattia, additional, Riccitelli, Serena, additional, Maccarone, Rita, additional, Mattei, Claudia, additional, Capannolo, Marta, additional, Rossi, Mario, additional, Capozzo, Annamaria, additional, Corsini, Giovanni U., additional, Scarnati, Eugenio, additional, Lozzi, Luca, additional, Vaglini, Francesca, additional, and Maggio, Roberto, additional

Published
2017
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16. Serotonin abnormalities in Engrailed-2 knockout mice: New insight relevant for a model of Autism Spectrum Disorder

Author

Viaggi, Cristina, Gerace, Claudio, Pardini, CARLA MARIA FRANCESCA, Corsini, GIOVANNI UMBERTO, Vaglini, Francesca, and Viaggi, MARIA CRISTINA

Subjects
Cerebellum, medicine.medical_specialty, Serotonin, Autism Spectrum Disorder, Hippocampus, Nerve Tissue Proteins, Cellular and Molecular Neuroscience, Mice, Cortex (anatomy), Internal medicine, medicine, Animals, Animal model, Engrailed 2, Homeodomain Proteins, Mice, Knockout, Serotonin Plasma Membrane Transport Proteins, Brain, Cell Biology, medicine.disease, medicine.anatomical_structure, Endocrinology, Cerebral cortex, Autism spectrum disorder, Cerebellar cortex, Knockout mouse, Psychology, Neuroscience
Abstract

Autism spectrum disorder (ASD) is a congenital neurodevelopmental behavioral disorder that appears in early childhood. Recent human genetic studies identified the homeobox transcription factor, Engrailed 2 (EN2), as a possible ASD susceptibility gene. En2 knockout mice (En2-/-) display subtle cerebellar neuropathological changes and reduced levels of tyrosine hydroxylase, noradrenaline and serotonin in the hippocampus and cerebral cortex similar to those ones which have been observed in the ASD brain. Furthermore other similarities link En2 knockout mice to ASD patients. Several lines of evidence suggest that serotonin may play an important role in the pathophysiology of the disease. In the present study we measured, by using an HPLC, the 5-HT levels in different brain areas and at different ages in En2-/- mice. In the frontal and occipital cortex, the content of 5HT was reduced in En2-/- 1 and 3 months old mice; in 6 month old mice, the difference was still present, but it was not statistically significant. The 5-HT content of cerebellar cortex was significantly reduced at 1 month old but significantly high when the KO mice reached 3 months of age. The increase was present even at 6 months of age. A similar trend was highlighted by SERT immunolabeling in En2-/- mice compared to control in the same areas and age analyzed. Our findings, in agreement with the current knowledge on the 5-HT system alterations in ASD, confirm the early neurotransmitter deficit with a late compensatory recovery in En2 KO-mice further suggesting that this experimental animal may be considered a good predictive model for the human disease.

Published
2014

18. Bright light exposure reduces TH-positive dopamine neurons: implications of light pollution in Parkinson's disease epidemiology

Author

Romeo, Stefania, primary, Viaggi, Cristina, additional, Di Camillo, Daniela, additional, Willis, Allison W., additional, Lozzi, Luca, additional, Rocchi, Cristina, additional, Capannolo, Marta, additional, Aloisi, Gabriella, additional, Vaglini, Francesca, additional, Maccarone, Rita, additional, Caleo, Matteo, additional, Missale, Cristina, additional, Racette, Brad A., additional, Corsini, Giovanni U., additional, and Maggio, Roberto, additional

Published
2013
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23. Pharmacological Strategies for Bipolar Disorders in Acute Phases and Chronic Management with a Special Focus on Lithium, Valproic Acid, and Atypical Antipsychotics.

Author

Carli M, Weiss F, Grenno G, Ponzini S, Kolachalam S, Vaglini F, Viaggi C, Pardini C, Tidona S, Longoni B, Maggio R, and Scarselli M

Subjects
Humans, Valproic Acid therapeutic use, Lithium therapeutic use, Antimanic Agents therapeutic use, Anticonvulsants therapeutic use, Cyclothymic Disorder, Antipsychotic Agents therapeutic use, Bipolar Disorder diagnosis
Abstract

Bipolar disorders (BDs) are a heterogeneous group of severe affective disorders generally described by the alternation of (hypo)manic, depressive, and mixed phases, with euthymic intervals of variable duration. BDs are burdened with high psychiatric and physical comorbidity, increased suicide risk and reduced life expectancy. In addition, BDs can progress into complicated forms (e.g., mixed states, rapid/irregular cycling), which are more difficult to treat and often require personalized pharmacological combinations. Mood stabilizers, particularly Lithium and Valproic acid (VPA), still represent the cornerstones of both acute and chronic pharmacotherapies of BDs. Lithium is the gold standard in BD-I and BDII with typical features, while VPA seems more effective for atypical forms (e.g., mixed-prevalence and rapid-cycling). However, despite appropriate mood stabilization, many patients show residual symptoms, and more than a half recur within 1-2 years, highlighting the need of additional strategies. Among these, the association of atypical antipsychotics (AAPs) with mood stabilizers is recurrent in the treatment of acute phases, but it is also being growingly explored in the maintenance pharmacotherapy. These combinations are clinically more aggressive and often needed in the acute phases, whereas simplifying pharmacotherapies to mood stabilizers only is preferable in the long-term, whenever possible. When mood stabilizers are not enough for maintenance treatment, Quetiapine and, less consistently, Aripiprazole have been proposed as the most advisable adjunctive strategies, for their safety and tolerability profiles. However, in view of the increased risk of serious adverse effects, a careful patient-centered balance between costs and benefits is mandatory., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Published
2023
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