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4. Pedalling toward a deeper understanding of exercise effects on immune function.

Author

Via, Jeremy, Reid, Jill, and Oehlert, Garrett

Subjects
*EXERCISE physiology, *TRANSCRIPTION factors, *LEUKOCYTE count, *T helper cells, *PYRIN (Protein), *LACTATES
Abstract

This article examines the effects of exercise on immune function, specifically inflammation and cardiovascular health. It discusses how exercise can stimulate the production of anti-inflammatory cytokines and leukocytes, aiding in tissue repair and reducing inflammation. However, intense exercise has been found to temporarily suppress the immune system and decrease the effectiveness of anti-inflammatory cytokines in individuals at risk for heart disease. The study also investigates the impact of exercise on monocyte polarization and finds that exercise does not significantly influence the polarization of monocytes towards pro-inflammatory or anti-inflammatory states. The study emphasizes the importance of measuring both anti-inflammatory activity and phenotype polarization when studying the effects of exercise on inflammation. Further research is needed to understand the effects of different exercise protocols on immune function, particularly in less active individuals, and to explore sex differences. Additionally, more research is warranted on the mechanisms by which exercise affects monocyte subset polarization and the production and effects of other inflammatory cytokines. Overall, this study provides valuable insights into the relationship between exercise and inflammation, laying the groundwork for future research in exercise immunology. [Extracted from the article]

Published
2024
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9. Prevalence of Cardiovascular Diseases Among Breast Cancer Survivors: Findings From the NHANES 2003-2018

Author

Kim, Youngdeok, primary, Franco, R. Lee, additional, Lucas, Alexander R., additional, Sutton, Arnethea L., additional, LaRose, Jessica G., additional, Kenyon, Jonathan, additional, Via, Jeremy, additional, Cheng, Richard K., additional, D’Agostino, Ralph, B., additional, Sheppard, Vanessa B., additional, and Hundley, W. Gregory, additional

Published
2022
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12. Prevalence of Cardiovascular Diseases Among Breast Cancer Survivors: Findings From the NHANES 2003-2018

Author

Kim, Youngdeok, Franco, R. Lee, Lucas, Alexander R., Sutton, Arnethea L., LaRose, Jessica G., Kenyon, Jonathan, Via, Jeremy, Cheng, Richard K., Ralph, D’Agostino, B., Sheppard, Vanessa B., and Hundley, W. Gregory

Abstract

Purpose To examine the prevalence of cardiovascular diseases (CVD) among breast cancer (BC) survivors.Design Cross-sectional observational study using the data from the National Health and Nutrition Examination Survey (NHANES) 2003–2018.Setting United States (US).Subjects A nationally representative sample of US women with a history of BC.Measures Self-reported CVD status (i.e., coronary artery disease (CAD), heart failure, and stroke) and time of the CVD diagnosis were used to categorize BC survivors into three groups: No CVD, preexisting CVD, and post-acquired CVD after BC diagnosis.Analysis The prevalence of CVD among BC survivors were estimated by demographic characteristics. Complex sampling design of the NHANES was accounted to estimate the population-level prevalence.Results A total of 658 BC survivors were identified, representing 3.01% (≈3.4 million) of the US women aged ≥18 years old. Of those, ≈6% (≈.2 million) had preexisting CVD and ≈11% (≈.4 million) had at least one CVD diagnosed after BC diagnosis, with an average time elapsed ranging from ≈5 years for heart failure to ≈9 years for CAD and stroke. The prevalence of CVD among BC survivors differed by demographic characteristics including age, education, marital status, menopausal, and physical activity levels.Conclusion Our findings suggest that BC survivors are at risk of suffering from CVD and public health strategies for the long-term management of CVD risk factors in this vulnerable population group is recommended.

Published
2023
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