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248 results on '"Vettoretti, Simone"'

8. Frailty Is Associated with Malnutrition–Inflammation Syndrome in Older CKD Patients.

Author

Molinari, Paolo, Caldiroli, Lara, Abinti, Matteo, Nardelli, Luca, Armelloni, Silvia, Cesari, Matteo, Castellano, Giuseppe, and Vettoretti, Simone

Abstract

Patients affected by chronic kidney disease (CKD) are generally considered to be frailer than those with preserved renal function. We cross-sectionally evaluated the associations between frailty, malnutrition–inflammation syndrome and circulating inflammatory cytokines in 115 older individuals with advanced CKD. As for frailty definition, we adopted Fried's frailty phenotype (FP), while malnutrition–inflammation syndrome was assessed using the Malnutrition–Inflammation Score (MIS) and circulating inflammatory cytokines (IL-6; TNFα; MCP-1). A total of 48 patients were frail, and mean eGFR was comparable in both frail and non-frail patients (24 ± 10 vs. 25 ± 11 mL/min/1.73 m2; p = 0.63). Frail patients had higher MIS (6 [4–11] vs. 4 [3–5]; p < 0.0001) but cytokine concentrations were comparable in both groups. At multivariate regression, FP was independently associated with MIS, age, gender and pre-albumin but not with cytokines. However, we found some associations between inflammatory cytokines and some specific frailty criteria: weight loss and slowness were associated with MCP-1 (respectively p = 0.049 and p < 0.0001) and weakness with IL-6 (p = 0.005); in conclusion, in older patients with advanced CKD, frailty is strictly associated with malnutrition–inflammation syndrome but not with circulating inflammatory cytokines. [ABSTRACT FROM AUTHOR]

Published
2024
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10. What Not to Overlook in the Management of Patients with Type 2 Diabetes Mellitus: The Nephrological and Hepatological Perspectives.

Author

Alfieri, Carlo Maria, Molinari, Paolo, Cinque, Felice, Vettoretti, Simone, Cespiati, Annalisa, Bignamini, Daniela, Nardelli, Luca, Fracanzani, Anna Ludovica, Castellano, Giuseppe, and Lombardi, Rosa

Subjects
TYPE 2 diabetes, DIABETIC nephropathies, CAROTID intima-media thickness, GLYCEMIC control, REDUCING diets, DIABETES
Abstract

Diabetes mellitus (DM) significantly impacts renal and hepatic function, necessitating comprehensive understanding and management strategies. Renal involvement, namely diabetic kidney disease (DKD), presents a global challenge, with increasing prevalence paralleling DM rates. Lifestyle modifications and pharmacotherapy targeting hypertension and glycemic control have pivotal roles in DKD management. Concurrently, hepatic involvement in DM, characterized by metabolic dysfunction-associated steatotic liver disease (MASLD), presents a bidirectional relationship. DM exacerbates MASLD progression, while MASLD predisposes to DM development and worsens glycemic control. Screening for MASLD in DM patients is of high importance, utilizing non-invasive methods like ultrasound and fibrosis scores. Lifestyle modifications, such as weight loss and a Mediterranean diet, mitigate MASLD progression. Promising pharmacotherapies, like SGLT2 inhibitors and GLP-1 agonists, demonstrate efficacy in both DM and MASLD management. Special populations, such as diabetic individuals undergoing hemodialysis or kidney transplant recipients, demand special care due to unique clinical features. Similarly, DM exacerbates complications in MASLD patients, elevating the risks of hepatic decompensation and hepatocellular carcinoma. Recognizing the interconnectedness of DM, renal, and hepatic diseases underscores the need for multidisciplinary approaches for optimal patient outcomes. The present review aims to present the main characteristics and crucial points not to be overlooked regarding the renal and hepatic involvement in DM patients focusing on the inter-relationships between the renal and the hepatic involvements. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Corrigendum: Impact of hyperparathyroidism and its different subtypes on long term graft outcome: a single Transplant Center cohort study

Author

Molinari, Paolo, primary, Regalia, Anna, additional, Leoni, Alessandro, additional, Campise, Mariarosaria, additional, Cresseri, Donata, additional, Cicero, Elisa, additional, Vettoretti, Simone, additional, Nardelli, Luca, additional, Brigati, Emilietta, additional, Favi, Evaldo, additional, Messa, Piergiorgio, additional, Castellano, Giuseppe, additional, and Alfieri, Carlo M., additional

Published
2024
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17. MCP1 Inverts the Correlation between FGF23 and Omega 6/3 Ratio: Is It Also True in Renal Transplantation?

Author

Mattinzoli, Deborah, primary, Turolo, Stefano, additional, Ikehata, Masami, additional, Vettoretti, Simone, additional, Montini, Giovanni, additional, Agostoni, Carlo, additional, Conti, Costanza, additional, Benedetti, Matteo, additional, Messa, Piergiorgio, additional, Alfieri, Carlo Maria, additional, and Castellano, Giuseppe, additional

Published
2023
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18. Impact of hyperparathyroidism and its different subtypes on long term graft outcome: a single Transplant Center cohort study

Author

Molinari, Paolo, primary, Regalia, Anna, additional, Leoni, Alessandro, additional, Campise, Mariarosaria, additional, Cresseri, Donata, additional, Cicero, Elisa, additional, Vettoretti, Simone, additional, Nardelli, Luca, additional, Brigatti, Emilietta, additional, Favi, Evaldo, additional, Messa, Piergiorgio, additional, Castellano, Giuseppe, additional, and Alfieri, Carlo M., additional

Published
2023
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25. Association of Autofluorescent Advanced Glycation End Products (AGEs) with Frailty Components in Chronic Kidney Disease (CKD): Data from a Single-Center Cohort Study

Author

Molinari, Paolo, primary, Caldiroli, Lara, additional, Dozio, Elena, additional, Rigolini, Roberta, additional, Giubbilini, Paola, additional, Carminati, Francesca Maria Ida, additional, Castellano, Giuseppe, additional, Corsi Romanelli, Massimiliano M., additional, and Vettoretti, Simone, additional

Published
2023
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26. MCP1 Could Mediate FGF23 and Omega 6/Omega 3 Correlation Inversion in CKD

Author

Mattinzoli, Deborah, primary, Turolo, Stefano, additional, Alfieri, Carlo Maria, additional, Ikehata, Masami, additional, Caldiroli, Lara, additional, Armelloni, Silvia, additional, Montini, Giovanni, additional, Agostoni, Carlo, additional, Messa, Piergiorgio, additional, Vettoretti, Simone, additional, and Castellano, Giuseppe, additional

Published
2022
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32. A new CHA2DS2VASC score integrated with estimated glomerular filtration rate, left ventricular hypertrophy, and pulse pressure is highly effective in predicting adverse cardiovascular outcome in chronic kidney disease

Author

Bussalino, Elisabetta, primary, Ravera, Maura, additional, Minutolo, Roberto, additional, Vettoretti, Simone, additional, Di Lullo, Luca, additional, Fusaro, Maria, additional, De Nicola, Luca, additional, and Paoletti, Ernesto, additional

Published
2022
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37. Association of Sarcopenia and Gut Microbiota Composition in Older Patients with Advanced Chronic Kidney Disease, Investigation of the Interactions with Uremic Toxins, Inflammation and Oxidative Stress

Author

Margiotta, Elisabetta, primary, Caldiroli, Lara, additional, Callegari, Maria Luisa, additional, Miragoli, Francesco, additional, Zanoni, Francesca, additional, Armelloni, Silvia, additional, Rizzo, Vittoria, additional, Messa, Piergiorgio, additional, and Vettoretti, Simone, additional

Published
2021
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38. Calcium carbonate-enriched cheese to improve nutrition, compliance and phosphorus control in patients on kidney replacement therapy

Author

Ardissino, Gianluigi, primary, Matta, Roberto, additional, Patricelli, Mariagrazia, additional, Capone, Valentina, additional, Leoni, Antonio, additional, Groppelli, Antonio, additional, Vettoretti, Simone, additional, Pavone, Laura, additional, Margiotta, Elisabetta, additional, Brancadoro, Annamaria, additional, Grimaldi, Emanuele, additional, Cropanese, Isabella, additional, Raffiotta, Francesca, additional, Messa, Piergiorgio, additional, and Montini, Giovanni, additional

Published
2021
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42. Gut microbiota composition and frailty in elderly patients with Chronic Kidney Disease

Author

Margiotta, Elisabetta, Miragoli, Francesco, Callegari, Maria Luisa, Vettoretti, Simone, Caldiroli, Lara, Meneghini, Maria, Zanoni, Francesca, Messa, Piergiorgio, Francesco Miragoli, Maria Luisa Callegari (ORCID:0000-0002-7811-5305), Margiotta, Elisabetta, Miragoli, Francesco, Callegari, Maria Luisa, Vettoretti, Simone, Caldiroli, Lara, Meneghini, Maria, Zanoni, Francesca, Messa, Piergiorgio, Francesco Miragoli, and Maria Luisa Callegari (ORCID:0000-0002-7811-5305)

Abstract

Background: Frailty is common in older patients affected by chronic kidney disease (CKD). Since gut microbiota (gMB) may contribute to frailty, we explored possible associations between gMB and frailty in CKD. Methods: We studied 64 CKD patients (stage 3b-4), categorized as frail (F, 38) and not frail (NF, 26) according to Fried criteria, and 15 controls (C), all older than 65 years. In CKD we assessed serum C-reactive protein, blood neutrophil/lymphocyte ratio, Malnutrition-inflammation Score (MIS); gMB was studied by denaturing gel gradient electrophoresis (DGGE), high-throughput sequencing (16S ribosomal RNA), and quantitative real-time PCR (qPCR). Results: No differences in alpha and beta diversity between CKD and C and between F and NF patients emerged, but high-throughput sequencing showed significantly higher abundance of potentially noxious bacteria (Citrobacter, Coprobacillus, etc) and lower abundance of saccharolytic and butyrate-producing bacteria (Prevotella, F. prausnitzii, Roseburia), in CKD respect to C. Mogibacteriaceae and Oscillospira abundance was positively related to inflammatory indices in the whole CKD cohort, while that of Akkermansia, Ruminococcus and Eubacterium was negatively related. Compared with NF, in F there was a higher abundance of some bacteria (Mogibacteriacee, Coriobacteriacee, Eggerthella, etc), many of which have been described as more abundant in other diseases. Conclusions: These results suggest that inflammation and frailty could be associated to gMB modifications in CKD.

Published
2020

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