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3. Identification of frequent la Niña events during the early 1800s in the east equatorial Pacific

Author

Druffel, ERM, Griffin, S, Vetter, D, Dunbar, RB, and Mucciarone, DM

Subjects
Meteorology & Atmospheric Sciences
Abstract

We report measurements of near monthly Δ14C and δ18O during selected decades from an east equatorial Pacific coral that grew during the past four centuries. We find that El Niño events occurred regularly during the late 1700s. During the early 1800s, El Niño events occurred less often, and La Niña conditions prevailed, which were accompanied by unprecedented, low cool season Δ14C values and high cool season δ18O values. These results indicate that shallow overturning water (e.g., Central Mode Water) from the North Pacific was likely an important source of water to the Galapagos area during the early 1800s.

Published
2015

7. Metastatic Pheochromocytoma and Paraganglioma: Somatostatin Receptor 2 Expression, Genetics, and Therapeutic Responses.

Author

Fischer, A., Kloos, S., Maccio, U., Friemel, J., Remde, H., Fassnacht, M., Pamporaki, C., Eisenhofer, G., Timmers, H.J.L.M., Robledo, M., Fliedner, S.M.J., Wang, K., Maurer, J., Reul, A., Zitzmann, K., Bechmann, N., Žygienė, G., Richter, S., Hantel, C., Vetter, D., Lehmann, K., Mohr, H., Pellegata, N.S., Ullrich, M., Pietzsch, J., Ziegler, C.G., Bornstein, S.R., Kroiss, M., Reincke, M., Pacak, K., Grossman, A.B., Beuschlein, F., Nölting, S., Fischer, A., Kloos, S., Maccio, U., Friemel, J., Remde, H., Fassnacht, M., Pamporaki, C., Eisenhofer, G., Timmers, H.J.L.M., Robledo, M., Fliedner, S.M.J., Wang, K., Maurer, J., Reul, A., Zitzmann, K., Bechmann, N., Žygienė, G., Richter, S., Hantel, C., Vetter, D., Lehmann, K., Mohr, H., Pellegata, N.S., Ullrich, M., Pietzsch, J., Ziegler, C.G., Bornstein, S.R., Kroiss, M., Reincke, M., Pacak, K., Grossman, A.B., Beuschlein, F., and Nölting, S.

Abstract

Contains fulltext : 296796.pdf (Publisher’s version ) (Open Access), CONTEXT: Pheochromocytomas and paragangliomas (PPGLs) with pathogenic mutations in the succinate dehydrogenase subunit B (SDHB) are associated with a high metastatic risk. Somatostatin receptor 2 (SSTR2)-dependent imaging is the most sensitive imaging modality for SDHB-related PPGLs, suggesting that SSTR2 expression is a significant cell surface therapeutic biomarker of such tumors. OBJECTIVE: Exploration of the relationship between SSTR2 immunoreactivity and SDHB immunoreactivity, mutational status, and clinical behavior of PPGLs. Evaluation of SSTR-based therapies in metastatic PPGLs. METHODS: Retrospective analysis of a multicenter cohort of PPGLs at 6 specialized Endocrine Tumor Centers in Germany, The Netherlands, and Switzerland. Patients with PPGLs participating in the ENSAT registry were included. Clinical data were extracted from medical records, and immunohistochemistry (IHC) for SDHB and SSTR2 was performed in patients with available tumor tissue. Immunoreactivity of SSTR2 was investigated using Volante scores. The main outcome measure was the association of SSTR2 IHC positivity with genetic and clinical-pathological features of PPGLs. RESULTS: Of 202 patients with PPGLs, 50% were SSTR2 positive. SSTR2 positivity was significantly associated with SDHB- and SDHx-related PPGLs, with the strongest SSTR2 staining intensity in SDHB-related PPGLs (P = .01). Moreover, SSTR2 expression was significantly associated with metastatic disease independent of SDHB/SDHx mutation status (P < .001). In metastatic PPGLs, the disease control rate with first-line SSTR-based radionuclide therapy was 67% (n = 22, n = 11 SDHx), and with first-line "cold" somatostatin analogs 100% (n = 6, n = 3 SDHx). CONCLUSION: SSTR2 expression was independently associated with SDHB/SDHx mutations and metastatic disease. We confirm a high disease control rate of somatostatin receptor-based therapies in metastatic PPGLs.

Published
2023

9. Assessing Trustworthy AI in Times of COVID-19: Deep Learning for Predicting a Multiregional Score Conveying the Degree of Lung Compromise in COVID-19 Patients.

Author

Allahabadi, H, Amann, J, Balot, I, Beretta, A, Binkley, C, Bozenhard, J, Bruneault, F, Brusseau, J, Candemir, S, Cappellini, LA, Chakraborty, S, Cherciu, N, Cociancig, C, Coffee, M, Ek, I, Espinosa-Leal, L, Farina, D, Fieux-Castagnet, G, Frauenfelder, T, Gallucci, A, Giuliani, G, Golda, A, van Halem, I, Hildt, E, Holm, S, Kararigas, G, Krier, SA, Kuhne, U, Lizzi, F, Madai, VI, Markus, AF, Masis, S, Mathez, EW, Mureddu, F, Neri, E, Osika, W, Ozols, M, Panigutti, C, Parent, B, Pratesi, F, Moreno-Sanchez, PA, Sartor, G, Savardi, M, Signoroni, A, Sormunen, H-M, Spezzatti, A, Srivastava, A, Stephansen, AF, Theng, LB, Tithi, JJ, Tuominen, J, Umbrello, S, Vaccher, F, Vetter, D, Westerlund, M, Wurth, R, Zicari, RV, Allahabadi, H, Amann, J, Balot, I, Beretta, A, Binkley, C, Bozenhard, J, Bruneault, F, Brusseau, J, Candemir, S, Cappellini, LA, Chakraborty, S, Cherciu, N, Cociancig, C, Coffee, M, Ek, I, Espinosa-Leal, L, Farina, D, Fieux-Castagnet, G, Frauenfelder, T, Gallucci, A, Giuliani, G, Golda, A, van Halem, I, Hildt, E, Holm, S, Kararigas, G, Krier, SA, Kuhne, U, Lizzi, F, Madai, VI, Markus, AF, Masis, S, Mathez, EW, Mureddu, F, Neri, E, Osika, W, Ozols, M, Panigutti, C, Parent, B, Pratesi, F, Moreno-Sanchez, PA, Sartor, G, Savardi, M, Signoroni, A, Sormunen, H-M, Spezzatti, A, Srivastava, A, Stephansen, AF, Theng, LB, Tithi, JJ, Tuominen, J, Umbrello, S, Vaccher, F, Vetter, D, Westerlund, M, Wurth, R, and Zicari, RV

Abstract

This article's main contributions are twofold: 1) to demonstrate how to apply the general European Union's High-Level Expert Group's (EU HLEG) guidelines for trustworthy AI in practice for the domain of healthcare and 2) to investigate the research question of what does "trustworthy AI" mean at the time of the COVID-19 pandemic. To this end, we present the results of a post-hoc self-assessment to evaluate the trustworthiness of an AI system for predicting a multiregional score conveying the degree of lung compromise in COVID-19 patients, developed and verified by an interdisciplinary team with members from academia, public hospitals, and industry in time of pandemic. The AI system aims to help radiologists to estimate and communicate the severity of damage in a patient's lung from Chest X-rays. It has been experimentally deployed in the radiology department of the ASST Spedali Civili clinic in Brescia, Italy, since December 2020 during pandemic time. The methodology we have applied for our post-hoc assessment, called Z-Inspection®, uses sociotechnical scenarios to identify ethical, technical, and domain-specific issues in the use of the AI system in the context of the pandemic.

Published
2022

16. Multicentre randomised phase III trial comparing Tamoxifen alone or with Transarterial Lipiodol Chemoembolisation for unresectable hepatocellular carcinoma in cirrhotic patients (Fédération Francophone de Cancérologie Digestive 9402)

Author

Doffoël, M., Bonnetain, F., Bouché, O., Vetter, D., Abergel, A., Fratté, S., Grangé, J.D., Stremsdoerfer, N., Blanchi, A., Bronowicki, J.P., Caroli-Bosc, F.X., Causse, X., Masskouri, F., Rougier, P., and Bedenne, L.

Published
2008
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18. Fit-for-Discharge Criteria after Esophagectomy: An International Expert Delphi Consensus

Author

Mueller, P. C., Kapp, J. R., Vetter, D., Bonavina, L., Brown, W., Castro, S., Cheong, E., Darling, G. E., Egberts, J., Ferri, L., Gisbertz, S. S., Gockel, I, Grimminger, P. P., Hofstetter, W. L., Hoelscher, A. H., Low, D. E., Luyer, M., Markar, S. R., Moenig, S. P., Moorthy, K., Morse, C. R., Mueller-Stich, B. P., Nafteux, P., Nieponice, A., Nieuwenhuijzen, G. A. P., Nilsson, M., Palanivelu, C., Pattyn, P., Pera, M., Rasanen, J., Ribeiro, U., Rosman, C., Schroeder, W., Sgromo, B., van Berge Henegouwen, M., I, van Hillegersberg, R., van Veer, H., van Workum, F., Watson, D., I, Wijnhoven, B. P. L., Gutschow, C. A., Mueller, P. C., Kapp, J. R., Vetter, D., Bonavina, L., Brown, W., Castro, S., Cheong, E., Darling, G. E., Egberts, J., Ferri, L., Gisbertz, S. S., Gockel, I, Grimminger, P. P., Hofstetter, W. L., Hoelscher, A. H., Low, D. E., Luyer, M., Markar, S. R., Moenig, S. P., Moorthy, K., Morse, C. R., Mueller-Stich, B. P., Nafteux, P., Nieponice, A., Nieuwenhuijzen, G. A. P., Nilsson, M., Palanivelu, C., Pattyn, P., Pera, M., Rasanen, J., Ribeiro, U., Rosman, C., Schroeder, W., Sgromo, B., van Berge Henegouwen, M., I, van Hillegersberg, R., van Veer, H., van Workum, F., Watson, D., I, Wijnhoven, B. P. L., and Gutschow, C. A.

Abstract

There are no internationally recognized criteria available to determine preparedness for hospital discharge after esophagectomy. This study aims to achieve international consensus using Delphi methodology. The expert panel consisted of 40 esophageal surgeons spanning 16 countries and 4 continents. During a 3-round, web-based Delphi process, experts voted for discharge criteria using 5-point Likert scales. Data were analyzed using descriptive statistics. Consensus was reached if agreement was >= 75% in round 3. Consensus was achieved for the following basic criteria: nutritional requirements are met by oral intake of at least liquids with optional supplementary nutrition via jejunal feeding tube. The patient should have passed flatus and does not require oxygen during mobilization or at rest. Central venous catheters should be removed. Adequate analgesia at rest and during mobilization is achieved using both oral opioid and non-opioid analgesics. All vital signs should be normal unless abnormal preoperatively. Inflammatory parameters should be trending down and close to normal (leucocyte count <= 12G/l and C-reactive protein <= 80 mg/dl). This multinational Delphi survey represents the first expert-led process for consensus criteria to determine 'fit-for-discharge' status after esophagectomy. Results of this Delphi survey may be applied to clinical outcomes research as an objective measure of short-term recovery. Furthermore, standardized endpoints identified through this process may be used in clinical practice to guide decisions regarding patient discharge and may help to reduce the risk of premature discharge or prolonged admission.

Published
2021

20. Fit-for-Discharge Criteria after Esophagectomy: An International Expert Delphi Consensus

Author

MS CGO, Cancer, Müller, P. C., Kapp, J. R., Vetter, D., Bonavina, L., Brown, W., Castro, S., Cheong, E., Darling, G. E., Egberts, J., Ferri, L., Gisbertz, S. S., Gockel, I., Grimminger, P. P., Hofstetter, W. L., Hölscher, A. H., Low, D. E., Luyer, M., Markar, S. R., Mönig, S. P., Moorthy, K., Morse, C. R., Müller-Stich, B. P., Nafteux, P., Nieponice, A., Nieuwenhuijzen, G. A.P., Nilsson, M., Palanivelu, C., Pattyn, P., Pera, M., Räsänen, J., Ribeiro, U., Rosman, C., Schröder, W., Sgromo, B., Van Berge Henegouwen, M. I., Van Hillegersberg, R., Van Veer, H., Van Workum, F., Watson, D. I., Wijnhoven, B. P.L., Gutschow, C. A., MS CGO, Cancer, Müller, P. C., Kapp, J. R., Vetter, D., Bonavina, L., Brown, W., Castro, S., Cheong, E., Darling, G. E., Egberts, J., Ferri, L., Gisbertz, S. S., Gockel, I., Grimminger, P. P., Hofstetter, W. L., Hölscher, A. H., Low, D. E., Luyer, M., Markar, S. R., Mönig, S. P., Moorthy, K., Morse, C. R., Müller-Stich, B. P., Nafteux, P., Nieponice, A., Nieuwenhuijzen, G. A.P., Nilsson, M., Palanivelu, C., Pattyn, P., Pera, M., Räsänen, J., Ribeiro, U., Rosman, C., Schröder, W., Sgromo, B., Van Berge Henegouwen, M. I., Van Hillegersberg, R., Van Veer, H., Van Workum, F., Watson, D. I., Wijnhoven, B. P.L., and Gutschow, C. A.

Published
2021

38. Fit-for-Discharge Criteria after Esophagectomy: An International Expert Delphi Consensus

Author

Müller, P C, primary, Kapp, J R, additional, Vetter, D, additional, Bonavina, L, additional, Brown, W, additional, Castro, S, additional, Cheong, E, additional, Darling, G E, additional, Egberts, J, additional, Ferri, L, additional, Gisbertz, S S, additional, Gockel, I, additional, Grimminger, P P, additional, Hofstetter, W L, additional, Hölscher, A H, additional, Low, D E, additional, Luyer, M, additional, Markar, S R, additional, Mönig, S P, additional, Moorthy, K, additional, Morse, C R, additional, Müller-Stich, B P, additional, Nafteux, P, additional, Nieponice, A, additional, Nieuwenhuijzen, G A P, additional, Nilsson, M, additional, Palanivelu, C, additional, Pattyn, P, additional, Pera, M, additional, Räsänen, J, additional, Ribeiro, U, additional, Rosman, C, additional, Schröder, W, additional, Sgromo, B, additional, van Berge Henegouwen, M I, additional, van Hillegersberg, R, additional, van Veer, H, additional, van Workum, F, additional, Watson, D I, additional, Wijnhoven, B P L, additional, and Gutschow, C A, additional

Published
2020
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40. Retreatment with interferon and ribavirin vs interferon alone according to viraemia in interferon responder-relapser hepatitis C patients: a prospective multicentre randomized controlled study

Author

Portal, I., Bourlière, M., Halfon, P., De Lédinghen, V., Couzigou, P., Bernard, P. H., Blanc, F., Caroli-Bosc, F., Arpurt, J. P., Vetter, D., Mathieu-Chandelier, C., Chazouillères, O., Thiefin, G., Pol, S., Sogni, P., Abergel, A., Bailly, F., Picon, M., Debonne, J. M., Zamora, C., Alleman, I., Moreau, X., Doll, F., Eugène, C., Ducloux, S., Larrey, D., Ouzan, D., Grimaud, J. C., Gouvernet, J., Botti, G., Gérolami, V., Khiri, H., Gérolami, A., Gauthier, A. P., and Botta-Fridlund, D.

Published
2003

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