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2. Correction: The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium

Author

Bruin, Willem B, Abe, Yoshinari, Alonso, Pino, Anticevic, Alan, Backhausen, Lea L, Balachander, Srinivas, Bargallo, Nuria, Batistuzzo, Marcelo C, Benedetti, Francesco, Bertolin Triquell, Sara, Brem, Silvia, Calesella, Federico, Couto, Beatriz, Denys, Damiaan AJP, Echevarria, Marco AN, Eng, Goi Khia, Ferreira, Sónia, Feusner, Jamie D, Grazioplene, Rachael G, Gruner, Patricia, Guo, Joyce Y, Hagen, Kristen, Hansen, Bjarne, Hirano, Yoshiyuki, Hoexter, Marcelo Q, Jahanshad, Neda, Jaspers-Fayer, Fern, Kasprzak, Selina, Kim, Minah, Koch, Kathrin, Bin Kwak, Yoo, Kwon, Jun Soo, Lazaro, Luisa, Li, Chiang-Shan R, Lochner, Christine, Marsh, Rachel, Martínez-Zalacaín, Ignacio, Menchon, Jose M, Moreira, Pedro S, Morgado, Pedro, Nakagawa, Akiko, Nakao, Tomohiro, Narayanaswamy, Janardhanan C, Nurmi, Erika L, Zorrilla, Jose C Pariente, Piacentini, John, Picó-Pérez, Maria, Piras, Fabrizio, Piras, Federica, Pittenger, Christopher, Reddy, Janardhan YC, Rodriguez-Manrique, Daniela, Sakai, Yuki, Shimizu, Eiji, Shivakumar, Venkataram, Simpson, Blair H, Soriano-Mas, Carles, Sousa, Nuno, Spalletta, Gianfranco, Stern, Emily R, Evelyn Stewart, S, Szeszko, Philip R, Tang, Jinsong, Thomopoulos, Sophia I, Thorsen, Anders L, Yoshida, Tokiko, Tomiyama, Hirofumi, Vai, Benedetta, Veer, Ilya M, Venkatasubramanian, Ganesan, Vetter, Nora C, Vriend, Chris, Walitza, Susanne, Waller, Lea, Wang, Zhen, Watanabe, Anri, Wolff, Nicole, Yun, Je-Yeon, Zhao, Qing, van Leeuwen, Wieke A, van Marle, Hein JF, van de Mortel, Laurens A, van der Straten, Anouk, van der Werf, Ysbrand D, Thompson, Paul M, Stein, Dan J, van den Heuvel, Odile A, and van Wingen, Guido A

Subjects
Biomedical and Clinical Sciences, Biological Psychology, Clinical and Health Psychology, Clinical Sciences, Psychology, Machine Learning and Artificial Intelligence, Mental Illness, Serious Mental Illness, Brain Disorders, Anxiety Disorders, Mental Health, Good Health and Well Being, ENIGMA-OCD Working Group, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology, Clinical and health psychology
Abstract

Correction to: Molecular Psychiatry, published online 2 May 2023 In this article Honami Arai, Irene Bollettini, Rosa Calvo Escalona, Ana Coelho, Federica Colombo, Leila Darwich, Martine Fontaine, Toshikazu Ikuta, Jonathan C. Ipser, Asier Juaneda-Seguí, Hitomi Kitagawa, Gerd Kvale, Mafalda Machado-Sousa, Astrid Morer, Takashi Nakamae, Jin Narumoto, Joseph O’Neill, Sho Okawa, Eva Real, Veit Roessner, Joao R. Sato, Cinto Segalàs, Roseli G. Shavitt, Dick J. Veltman, Kei Yamada were missing from the author list indexed under the ENIGMA-OCD Working Group. Additionally, there was an error regarding Tokiko Yoshida’s name, where the first name and last name were written in the wrong order. The original article has been corrected.

Published
2023

3. The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium.

Author

Bruin, Willem, Abe, Yoshinari, Alonso, Pino, Anticevic, Alan, Backhausen, Lea, Balachander, Srinivas, Bargallo, Nuria, Batistuzzo, Marcelo, Benedetti, Francesco, Bertolin Triquell, Sara, Brem, Silvia, Calesella, Federico, Couto, Beatriz, Denys, Damiaan, Echevarria, Marco, Eng, Goi, Ferreira, Sónia, Feusner, Jamie, Grazioplene, Rachael, Gruner, Patricia, Guo, Joyce, Hagen, Kristen, Hansen, Bjarne, Hirano, Yoshiyuki, Hoexter, Marcelo, Jahanshad, Neda, Jaspers-Fayer, Fern, Kasprzak, Selina, Kim, Minah, Koch, Kathrin, Bin Kwak, Yoo, Kwon, Jun, Lazaro, Luisa, Li, Chiang-Shan, Lochner, Christine, Marsh, Rachel, Martínez-Zalacaín, Ignacio, Menchon, Jose, Moreira, Pedro, Morgado, Pedro, Nakagawa, Akiko, Nakao, Tomohiro, Narayanaswamy, Janardhanan, Nurmi, Erika, Zorrilla, Jose, Picó-Pérez, Maria, Piras, Fabrizio, Piras, Federica, Pittenger, Christopher, Reddy, Janardhan, Rodriguez-Manrique, Daniela, Sakai, Yuki, Shimizu, Eiji, Shivakumar, Venkataram, Simpson, Blair, Soriano-Mas, Carles, Sousa, Nuno, Spalletta, Gianfranco, Stern, Emily, Evelyn Stewart, S, Szeszko, Philip, Tang, Jinsong, Thomopoulos, Sophia, Thorsen, Anders, Yoshida, Tokiko, Tomiyama, Hirofumi, Vai, Benedetta, Veer, Ilya, Venkatasubramanian, Ganesan, Vetter, Nora, Vriend, Chris, Walitza, Susanne, Waller, Lea, Wang, Zhen, Watanabe, Anri, Wolff, Nicole, Yun, Je-Yeon, Zhao, Qing, van Leeuwen, Wieke, van Marle, Hein, van de Mortel, Laurens, van der Straten, Anouk, van der Werf, Ysbrand, Thompson, Paul, Stein, Dan, van den Heuvel, Odile, van Wingen, Guido, and Piacentini, John

Subjects
Humans, Connectome, Brain Mapping, Magnetic Resonance Imaging, Brain, Obsessive-Compulsive Disorder, Biomarkers, Neural Pathways
Abstract

Current knowledge about functional connectivity in obsessive-compulsive disorder (OCD) is based on small-scale studies, limiting the generalizability of results. Moreover, the majority of studies have focused only on predefined regions or functional networks rather than connectivity throughout the entire brain. Here, we investigated differences in resting-state functional connectivity between OCD patients and healthy controls (HC) using mega-analysis of data from 1024 OCD patients and 1028 HC from 28 independent samples of the ENIGMA-OCD consortium. We assessed group differences in whole-brain functional connectivity at both the regional and network level, and investigated whether functional connectivity could serve as biomarker to identify patient status at the individual level using machine learning analysis. The mega-analyses revealed widespread abnormalities in functional connectivity in OCD, with global hypo-connectivity (Cohens d: -0.27 to -0.13) and few hyper-connections, mainly with the thalamus (Cohens d: 0.19 to 0.22). Most hypo-connections were located within the sensorimotor network and no fronto-striatal abnormalities were found. Overall, classification performances were poor, with area-under-the-receiver-operating-characteristic curve (AUC) scores ranging between 0.567 and 0.673, with better classification for medicated (AUC = 0.702) than unmedicated (AUC = 0.608) patients versus healthy controls. These findings provide partial support for existing pathophysiological models of OCD and highlight the important role of the sensorimotor network in OCD. However, resting-state connectivity does not so far provide an accurate biomarker for identifying patients at the individual level.

Published
2023

6. Cannabis-Associated Psychotic-like Experiences Are Mediated by Developmental Changes in the Parahippocampal Gyrus

Author

Rapp, Michael, Artiges, Eric, Schneider, Sophia, Bach, Christine, Paus, Tomas, Barbot, Alexis, Barker, Gareth, Bokde, Arun, Vetter, Nora, Büchel, Christian, Cattrell, Anna, Constant, Patrick, Gowland, Penny, Crombag, Hans, Czech, Katharina, Dalley, Jeffrey, Decideur, Benjamin, Spranger, Tade, Ripley, Tamzin, Heym, Nadja, Flor, Herta, Sommer, Wolfgang, Fuchs, Birgit, Gallinat, Jürgen, Garavan, Hugh, Spanagel, Rainer, Kaviani, Mehri, Heinrichs, Bert, Heinz, Andreas, Subramaniam, Naresh, Jia, Tianye, Ihlenfeld, Albrecht, Delosis, James Ireland, Ittermann, Bernd, Conrod, Patricia, Banaschewski, Tobias, Jones, Jennifer, Klaassen, Arno, Lalanne, Christophe, Lanzerath, Dirk, Lawrence, Claire, Lemaitre, Hervé, Desrivieres, Sylvane, Mallik, Catherine, Mann, Karl, Mar, Adam, Martinez-Medina, Lourdes, Martinot, Jean-Luc, Mennigen, Eva, de Carvahlo, Fabiana Mesquita, Schwartz, Yannick, Bruehl, Ruediger, Müller, Kathrin, Nees, Frauke, Nymberg, Charlotte, Lathrop, Mark, Robbins, Trevor, Pausova, Zdenka, Pentilla, Jani, Biondo, Francesca, Poline, Jean-Baptiste, Hohmann, Sarah, Poustka, Luise, Millenet, Sabina, Smolka, Michael, Fröhner, Juliane, Struve, Maren, Williams, Steve, Hübner, Thomas, Bromberg, Uli, Aydin, Semiha, Rogers, John, Romanowski, Alexander, Schmäl, Christine, Schmidt, Dirk, Ripke, Stephan, Arroyo, Mercedes, Schubert, Florian, Pena-Oliver, Yolanda, Fauth-Bühler, Mira, Mignon, Xavier, Whelan, Robert, Speiser, Claudia, Fadai, Tahmine, Stephens, Dai, Ströhle, Andreas, Paillere, Marie-Laure, Strache, Nicole, Theobald, David, Jurk, Sarah, Vulser, Helene, Miranda, Ruben, Yacubilin, Juliana, Frouin, Vincent, Genauck, Alexander, Parchetka, Caroline, Gemmeke, Isabel, Kruschwitz, Johann, WeiB, Katharina, Walter, Henrik, Feng, Jianfeng, Papadopoulos, Dimitri, Filippi, Irina, Ing, Alex, Ruggeri, Barbara, Xu, Bing, Macare, Christine, Chu, Congying, Hanratty, Eanna, Quinlan, Erin Burke, Robert, Gabriel, Schumann, Gunter, Yu, Tao, Ziesch, Veronika, Stedman, Alicia, Zhu, Liping, Desrivières, Sylvane, Bi, Yan, Bokde, Arun L.W., Liu, ChuanXin, Ji, Lei, Ren, Decheng, Du, Li, Hou, Binyin, Paillère Martinot, Marie-Laure, Orfanos, Dimitri Papadopoulos, Luo, Qiang, Smolka, Michael N., Vetter, Nora C., Lei, Cai, Fröhner, Juliane H., He, Guang, and He, Lin

Published
2020
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7. New Work

Author

Schirmer, Tim, primary, Gillhuber, Andreas, additional, Klaffke, Martin, additional, Hellert, Ulrike, additional, Gutzeit, Oliver, additional, Kempner, Frauke, additional, Rump, Jutta, additional, Eilers, Silke, additional, Gerlach, Gisela, additional, Schuster, Meika, additional, Klös, Hans-Peter, additional, Monsef, Roschan, additional, Schweitzer, Alexander, additional, Heß, Sophie, additional, Vetter, Nora Magdalena, additional, Frischmuth, Carlos, additional, Hormuth, Julia, additional, Drescher, Simon, additional, Zumkeller, Alexander, additional, Klier, Julia, additional, and König, Sebastian, additional

Published
2024
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8. Neuroimaging evidence for structural correlates in adolescents resilient to polysubstance use: A five-year follow-up study

Author

Filippi, Irina, Galinowski, André, Lemaître, Hervé, Massot, Christian, Zille, Pascal, Frère, Pauline, Miranda-Marcos, Rubén, Trichard, Christian, Guldner, Stella, Vulser, Hélène, Paillère-Martinot, Marie-Laure, Quinlan, Erin Burke, Desrivieres, Sylvane, Gowland, Penny, Bokde, Arun, Garavan, Hugh, Heinz, Andreas, Walter, Henrik, Daedelow, Laura, Büchel, Christian, Bromberg, Uli, Conrod, Patricia J., Flor, Herta, Banaschewski, Tobias, Nees, Frauke, Heintz, Stefan, Smolka, Michael, Vetter, Nora C., Papadopoulos-Orfanos, Dimitri, Whelan, Robert, Poustka, Louise, Paus, Tomas, Schumann, Gunter, Artiges, Eric, and Martinot, Jean-Luc

Published
2021
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9. Substance Use Initiation, Particularly Alcohol, in Drug-Naive Adolescents: Possible Predictors and Consequences From a Large Cohort Naturalistic Study

Author

Rapp, Michael, Artiges, Eric, Schneider, Sophia, Paus, Tomas, Barbot, Alexis, Barker, Gareth, Bokde, Arun, Vetter, Nora, Büchel, Christian, Cattrell, Anna, Constant, Patrick, Gowland, Penny, Crombag, Hans, Dalley, Jeffrey, Decideur, Benjamin, Spranger, Tade, Ripley, Tamzin, Heym, Nadja, Flor, Herta, Sommer, Wolfgang, Fuchs, Birgit, Gallinat, Jürgen, Garavan, Hugh, Spanagel, Rainer, Kaviani, Mehri, Heinrichs, Bert, Andreas Heinz, Subramaniam, Naresh, Jia, Tianye, Ihlenfeld, Albrecht, Ireland, James, Ittermann, Bernd, Conrod, Patricia, Banaschewski, Tobias, Jones, Jennifer, Klaassen, Arno, Lalanne, Christophe, Lanzerath, Dirk, Lawrence, Claire, Lemaitre, Hervé, Desrivieres, Sylvane, Mallik, Catherine, Mann, Karl, Mar, Adam, Martinez-Medina, Lourdes, Martinot, Jean-Luc, Mennigen, Eva, Mesquita de Carvahlo, Fabiana, Schwartz, Yannick, Bruehl, Ruediger, Müller, Kathrin, Nees, Frauke, Nymberg, Charlotte, Lathrop, Mark, Robbins, Trevor, Pausova, Zdenka, Pentilla, Jani, Biondo, Francesca, Poline, Jean-Baptiste, Poustka, Luise, Millenet, Sabina, Smolka, Michael, Fröhner, Juliane, Struve, Maren, Williams, Steve, Hübner, Thomas, Bromberg, Uli, Aydin, Semiha, Rogers, John, Romanowski, Alexander, Schmäl, Christine, Schmidt, Dirk, Ripke, Stephan, Arroyo, Mercedes, Schubert, Florian, Pena-Oliver, Yolanda, Fauth-Bühler, Mira, Mignon, Xavier, Whelan, Robert, Speiser, Claudia, Fadai, Tahmine, Stephens, Dai, Ströhle, Andreas, Paillere, Marie-Laure, Strache, Nicole, Theobald, David, Jurk, Sarah, Vulser, Helene, Miranda, Ruben, Yacubilin, Juliana, Frouin, Vincent, Genauck, Alexander, Parchetka, Caroline, Gemmeke, Isabel, Kruschwitz, Johann, WeiB, Katharina, Walter, Henrik, Feng, Jianfeng, Papadopoulos, Dimitri, Filippi, Irina, Ing, Alex, Ruggeri, Barbara, Xu, Bing, Macare, Christine, Chu, Congying, Hanratty, Eanna, Burke Quinlan, Erin, Robert, Gabriel, Schumann, Gunter, Yu, Tao, Ziesch, Veronika, Stedman, Alicia, Ivanov, Iliyan, Parvaz, Muhammad A., Velthorst, Eva, Shaik, Riaz B., Sandin, Sven, Gan, Gabriela, Spechler, Philip, Albaugh, Matthew D., Chaarani, Bader, Mackey, Scott, Bokde, Arun L.W., Quinlan, Erin Burke, Desrivières, Sylvane, Grigis, Antoine, Heinz, Andreas, Paillère Martinot, Marie-Laure, Lemaitre, Herve, Orfanos, Dimitri Papadopoulos, Paus, Tomáš, Hohmann, Sarah, Fröhner, Juliane H., and Smolka, Michael N.

Published
2021
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11. Sex effects on structural maturation of the limbic system and outcomes on emotional regulation during adolescence

Author

Frere, Pauline Bezivin, Vetter, Nora C., Artiges, Eric, Filippi, Irina, Miranda, Rubén, Vulser, Hélène, Paillère-Martinot, Marie-Laure, Ziesch, Veronika, Conrod, Patricia, Cattrell, Anna, Walter, Henrik, Gallinat, Jurgen, Bromberg, Uli, Jurk, Sarah, Menningen, Eva, Frouin, Vincent, Papadopoulos Orfanos, Dimitri, Stringaris, Argyris, Penttilä, Jani, van Noort, Betteke, Grimmer, Yvonne, Schumann, Gunter, Smolka, Michael N., Martinot, Jean-Luc, and Lemaître, Hervé

Published
2020
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12. Distinct brain structure and behavior related to ADHD and conduct disorder traits

Author

Bayard, Frida, Nymberg Thunell, Charlotte, Abé, Christoph, Almeida, Rita, Banaschewski, Tobias, Barker, Gareth, Bokde, Arun L. W., Bromberg, Uli, Büchel, Christian, Quinlan, Erin Burke, Desrivières, Sylvane, Flor, Herta, Frouin, Vincent, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Paus, Tomáš, Poustka, Luise, Conrod, Patricia, Stringaris, Argyris, Struve, Maren, Penttilä, Jani, Kappel, Viola, Grimmer, Yvonne, Fadai, Tahmine, van Noort, Betteke, Smolka, Michael N., Vetter, Nora C., Walter, Henrik, Whelan, Robert, Schumann, Gunter, and Petrovic, Predrag

Published
2020
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13. Neuroimaging Evidence for Right Orbitofrontal Cortex Differences in Adolescents With Emotional and Behavioral Dysregulation

Author

Banaschewski, Tobias, Barker, Gareth, Bokde, Arun L.W., Bromberg, Uli, Büchel, Christian, Quinlan, Erin Burke, Desrivières, Sylvane, Flor, Herta, Frouin, Vincent, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Paillère Martinot, Marie-Laure, Artiges, Eric, Lemaitre, Herve, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Paus, Tomáš, Poustka, Luise, Smolka, Michael N., Vetter, Nora C., Jurk, Sarah, Mennigen, Eva, Walter, Henrik, Whelan, Robert, Schumann, Gunter, Spechler, Philip A., Chaarani, Bader, Orr, Catherine, Mackey, Scott, Higgins, Stephen T., Conrod, Patricia J., Fröhner, Juliane H., and Althoff, Robert R.

Published
2019
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14. Low Smoking Exposure, the Adolescent Brain, and the Modulating Role of CHRNA5 Polymorphisms

Author

Mann, Karl, Struve, Maren, Rietschel, Marcella, Spanagel, Rainer, Fauth-Bühler, Mira, Millenet, Sabina, Grimmer, Yvonne, Ivanov, Nikolay, Strache, Nicole, Rapp, Michael, Ströhle, Andreas, Reuter, Jan, Barbot, Alexis, Thyreau, Benjamin, Schwartz, Yannick, Lalanne, Christophe, Bricaud, Zuleima, Briand, Fanny Gollier, Lemaitre, Hervé, Massicotte, Jessica, Vulser, Helene, Pentillä, Jani, Galinowski, André, Jia, Tianye, Werts, Helen, Topper, Lauren, Reed, Laurence, Andrew, Chris, Mallik, Catherine, Ruggeri, Barbara, Nymberg, Charlotte, Smith, Lindsay, Loth, Eva, Havatzias, Stephanie, Stueber, Kerstin, Stringaris, Argyris, Constant, Patrick, Brühl, Ruediger, Ihlenfeld, Albrecht, Walaszek, Bernadeta, Hübner, Thomas, Müller, Kathrin, Ripke, Stephan, Rodehacke, Sarah, Mennigen, Eva, Schmidt, Dirk, Vetter, Nora, Ziesch, Veronika, Jones, Jennifer, Poline, Jean-Baptiste, Fadai, Tahmine, Yacubian, Juliana, Schneider, Sophia, Lawrence, Claire, Newman, Craig, Head, Kay, Heym, Nadja, Pausova, Zdenka, Tahmasebi, Amir, Chaarani, Bader, Kan, Kees-Jan, Mackey, Scott, Spechler, Philip A., Potter, Alexandra, Orr, Catherine, D’Alberto, Nicholas, Hudson, Kelsey E., Banaschewski, Tobias, Bokde, Arun L.W., Bromberg, Uli, Büchel, Christian, Cattrell, Anna, Conrod, Patricia J., Desrivières, Sylvane, Flor, Herta, Frouin, Vincent, Gallinat, Jürgen, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Nees, Frauke, Papadopoulos-Orfanos, Dimitri, Paus, Tomáš, Poustka, Luise, Smolka, Michael N., Walter, Henrik, Whelan, Robert, Higgins, Stephen T., Schumann, Gunter, Althoff, Robert R., Stein, Elliot A., and Garavan, Hugh

Published
2019
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15. Neural Correlates of Failed Inhibitory Control as an Early Marker of Disordered Eating in Adolescents

Author

Rapp, Michael, Artiges, Eric, Schneider, Sophia, Bach, Christine, Paus, Tomas, Barbot, Alexis, Gareth Barker, Bokde, Arun, Vetter, Nora, Büchel, Christian, Cattrell, Anna, Constant, Patrick, Gowland, Penny, Crombag, Hans, Czech, Katharina, Dalley, Jeffrey, Decideur, Benjamin, Spranger, Tade, Ripley, Tamzin, Heym, Nadja, Flor, Herta, Sommer, Wolfgang, Fuchs, Birgit, Gallinat, Jürgen, Spanagel, Rainer, Kaviani, Mehri, Heinrichs, Bert, Andreas Heinz, Subramaniam, Naresh, Jia, Tianye, Ihlenfeld, Albrecht, Ireland, James, Ittermann, Bernd, Conrod, Patricia, Banaschewski, Tobias, Jones, Jennifer, Klaassen, Arno, Lalanne, Christophe, Lanzerath, Dirk, Lawrence, Claire, Lemaitre, Hervé, Desrivieres, Sylvane, Mallik, Catherine, Karl Mann, Mar, Adam, Martinez-Medina, Lourdes, Jean-Luc Martinot, Mennigen, Eva, Mesquita de Carvahlo, Fabiana, Schwartz, Yannick, Bruehl, Ruediger, Müller, Kathrin, Nees, Frauke, Nymberg, Charlotte, Lathrop, Mark, Trevor Robbins, Pausova, Zdenka, Jani Pentilla, Biondo, Francesca, Jean-Baptiste Poline, Hohmann, Sarah, Poustka, Luise, Millenet, Sabina, Michael Smolka, Fröhner, Juliane, Struve, Maren, Steve Williams, Hübner, Thomas, Bromberg, Uli, Aydin, Semiha, Rogers, John, Romanowski, Alexander, Schmäl, Christine, Schmidt, Dirk, Ripke, Stephan, Arroyo, Mercedes, Schubert, Florian, Pena-Oliver, Yolanda, Fauth-Bühler, Mira, Mignon, Xavier, Whelan, Robert, Speiser, Claudia, Fadai, Tahmine, Dai Stephens, Ströhle, Andreas, Paillere, Marie-Laure, Strache, Nicole, Theobald, David, Jurk, Sarah, Vulser, Helene, Miranda, Ruben, Yacubian, Juliana, Frouin, Vincent, Genauck, Alexander, Parchetka, Caroline, Gemmeke, Isabel, Kruschwitz, Johann, Weiß, Katharina, Walter, Henrik, Feng, Jianfeng, Papadopoulos, Dimitri, Filippi, Irina, Ing, Alex, Ruggeri, Barbara, Xu, Bing, Macare, Christine, Chu, Congying, Hanratty, Eanna, Burke Quinlan, Erin, Robert, Gabriel, Schumann, Gunter, Yu, Tao, Ziesch, Veronika, Stedman, Alicia, Bartholdy, Savani, O’Daly, Owen G., Campbell, Iain C., Barker, Gareth, Bokde, Arun L.W., Quinlan, Erin Burke, Desrivières, Sylvane, Garavan, Hugh, Heinz, Andreas, Martinot, Jean-Luc, Paillère Martinot, Marie-Laure, Orfanos, Dimitri Papadopoulos, Fröhner, Juliane H., Smolka, Michael N., and Schmidt, Ulrike

Published
2019
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16. Impact of a Common Genetic Variation Associated With Putamen Volume on Neural Mechanisms of Attention-Deficit/Hyperactivity Disorder

Author

Banaschewski, Tobias, Barker, Gareth, Bokde, Arun L.W., Bromberg, Uli, Büchel, Christian, Quinlan, Erin Burke, Desrivières, Sylvane, Flor, Herta, Frouin, Vincent, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Paillère Martinot, Marie-Laure, Artiges, Eric, Lemaitre, Herve, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Paus, Tomáš, Poustka, Luise, Smolka, Michael N., Vetter, Nora C., Jurk, Sarah, Mennigen, Eva, Walter, Henrik, Whelan, Robert, Schumann, Gunter, Xu, Bing, Jia, Tianye, Macare, Christine, Cattrell, Anna, Conrod, Patricia J., and Gallinat, Jürgen

Published
2017
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18. Interplay of early negative life events, development of orbitofrontal cortical thickness and depression in young adulthood

Author

Backhausen, Lea L., Granzow, Jonas, Fröhner, Juliane H., Artiges, Eric, Paillère‐Martinot, Marie‐Laure, Lemaître, Hervé, Sticca, Fabio, Banaschewski, Tobias, Desrivières, Sylvane, Grigis, Antoine, Heinz, Andreas, Brühl, Rüdiger, Papadopoulos‐Orfanos, Dimitri, Poustka, Luise, Hohmann, Sarah, Robinson, Lauren, Walter, Henrik, Winterer, Jeanne, Schumann, Gunter, Martinot, Jean‐Luc, Smolka, Michael N., Vetter, Nora C., Backhausen, Lea L., Granzow, Jonas, Fröhner, Juliane H., Artiges, Eric, Paillère‐Martinot, Marie‐Laure, Lemaître, Hervé, Sticca, Fabio, Banaschewski, Tobias, Desrivières, Sylvane, Grigis, Antoine, Heinz, Andreas, Brühl, Rüdiger, Papadopoulos‐Orfanos, Dimitri, Poustka, Luise, Hohmann, Sarah, Robinson, Lauren, Walter, Henrik, Winterer, Jeanne, Schumann, Gunter, Martinot, Jean‐Luc, Smolka, Michael N., and Vetter, Nora C.

Abstract

Background: Early negative life events (NLE) have long-lasting influences on neurodevelopment and psychopathology. Reduced orbitofrontal cortex (OFC) thickness was frequently associated with NLE and depressive symptoms. OFC thinning might mediate the effect of NLE on depressive symptoms, although few longitudinal studies exist. Using a complete longitudinal design with four time points, we examined whether NLE during childhood and early adolescence predict depressive symptoms in young adulthood through accelerated OFC thinning across adolescence. Methods: We acquired structural MRI from 321 participants at two sites across four time points from ages 14 to 22. We measured NLE with the Life Events Questionnaire at the first time point and depressive symptoms with the Center for Epidemiologic Studies Depression Scale at the fourth time point. Modeling latent growth curves, we tested whether OFC thinning mediates the effect of NLE on depressive symptoms. Results: A higher burden of NLE, a thicker OFC at the age of 14, and an accelerated OFC thinning across adolescence predicted young adults' depressive symptoms. We did not identify an effect of NLE on OFC thickness nor OFC thickness mediating effects of NLE on depressive symptoms. Conclusions: Using a complete longitudinal design with four waves, we show that NLE in childhood and early adolescence predict depressive symptoms in the long term. Results indicate that an accelerated OFC thinning may precede depressive symptoms. Assessment of early additionally to acute NLEs and neurodevelopment may be warranted in clinical settings to identify risk factors for depression.

Published
2023

19. Predictive utility of the NEO-FFI for later substance experiences among 16-year-old adolescents

Author

Parchetka, Caroline, Strache, Nicole, Raffaelli, Bianca, Gemmeke, Isabel, Weiß, Katharina, Artiges, Eric, Banaschewski, Tobias, Bokde, Arun, Bromberg, Uli, Buechel, Christian, Conrod, Patricia, Desrivières, Sylvane, Flor, Herta, Frouin, Vincent, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Lemaitre, Herve, Martinot, Jean-Luc, Mennigen, Eva, Nees, Frauke, Paillère Martinot, Marie-Laure, Papadopoulos, Dimitri, Paus, Tomáš, Poustka, Luise, Jurk, Sarah, Smolka, Michael N., Vetter, Nora C., Walter, Henrik, Whelan, Robert, Schumann, Gunter, Gallinat, Juergen, and and the IMAGEN consortium

Published
2016
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23. Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex

Author

Guadalupe, Tulio, Mathias, Samuel R., vanErp, Theo G. M., Whelan, Christopher D., Zwiers, Marcel P., Abe, Yoshinari, Abramovic, Lucija, Agartz, Ingrid, Andreassen, Ole A., Arias-Vásquez, Alejandro, Aribisala, Benjamin S., Armstrong, Nicola J., Arolt, Volker, Artiges, Eric, Ayesa-Arriola, Rosa, Baboyan, Vatche G., Banaschewski, Tobias, Barker, Gareth, Bastin, Mark E., Baune, Bernhard T., Blangero, John, Bokde, Arun L.W., Boedhoe, Premika S.W., Bose, Anushree, Brem, Silvia, Brodaty, Henry, Bromberg, Uli, Brooks, Samantha, Büchel, Christian, Buitelaar, Jan, Calhoun, Vince D., Cannon, Dara M., Cattrell, Anna, Cheng, Yuqi, Conrod, Patricia J., Conzelmann, Annette, Corvin, Aiden, Crespo-Facorro, Benedicto, Crivello, Fabrice, Dannlowski, Udo, de Zubicaray, Greig I., de Zwarte, Sonja M.C., Deary, Ian J., Desrivières, Sylvane, Doan, Nhat Trung, Donohoe, Gary, Dørum, Erlend S., Ehrlich, Stefan, Espeseth, Thomas, Fernández, Guillén, Flor, Herta, Fouche, Jean-Paul, Frouin, Vincent, Fukunaga, Masaki, Gallinat, Jürgen, Garavan, Hugh, Gill, Michael, Suarez, Andrea Gonzalez, Gowland, Penny, Grabe, Hans J., Grotegerd, Dominik, Gruber, Oliver, Hagenaars, Saskia, Hashimoto, Ryota, Hauser, Tobias U., Heinz, Andreas, Hibar, Derrek P., Hoekstra, Pieter J., Hoogman, Martine, Howells, Fleur M., Hu, Hao, Hulshoff Pol, Hilleke E., Huyser, Chaim, Ittermann, Bernd, Jahanshad, Neda, Jönsson, Erik G., Jurk, Sarah, Kahn, Rene S., Kelly, Sinead, Kraemer, Bernd, Kugel, Harald, Kwon, Jun Soo, Lemaitre, Herve, Lesch, Klaus-Peter, Lochner, Christine, Luciano, Michelle, Marquand, Andre F., Martin, Nicholas G., Martínez-Zalacaín, Ignacio, Martinot, Jean-Luc, Mataix-Cols, David, Mather, Karen, McDonald, Colm, McMahon, Katie L., Medland, Sarah E., Menchón, José M., Morris, Derek W., Mothersill, Omar, Maniega, Susana Munoz, Mwangi, Benson, Nakamae, Takashi, Nakao, Tomohiro, Narayanaswaamy, Janardhanan C., Nees, Frauke, Nordvik, Jan E., Onnink, A. Marten H., Opel, Nils, Ophoff, Roel, Paillère Martinot, Marie-Laure, Papadopoulos Orfanos, Dimitri, Pauli, Paul, Paus, Tomáš, Poustka, Luise, Reddy, Janardhan YC., Renteria, Miguel E., Roiz-Santiáñez, Roberto, Roos, Annerine, Royle, Natalie A., Sachdev, Perminder, Sánchez-Juan, Pascual, Schmaal, Lianne, Schumann, Gunter, Shumskaya, Elena, Smolka, Michael N., Soares, Jair C., Soriano-Mas, Carles, Stein, Dan J., Strike, Lachlan T., Toro, Roberto, Turner, Jessica A., Tzourio-Mazoyer, Nathalie, Uhlmann, Anne, Hernández, Maria Valdés, van den Heuvel, Odile A., van der Meer, Dennis, van Haren, Neeltje E.M ., Veltman, Dick J., Venkatasubramanian, Ganesan, Vetter, Nora C., Vuletic, Daniella, Walitza, Susanne, Walter, Henrik, Walton, Esther, Wang, Zhen, Wardlaw, Joanna, Wen, Wei, Westlye, Lars T., Whelan, Robert, Wittfeld, Katharina, Wolfers, Thomas, Wright, Margaret J., Xu, Jian, Xu, Xiufeng, Yun, Je-Yeon, Zhao, JingJing, Franke, Barbara, Thompson, Paul M., Glahn, David C., Mazoyer, Bernard, Fisher, Simon E., and Francks, Clyde

Published
2016
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24. Sex-related differences in frequency and perception of stressful life events during adolescence

Author

Raffaelli, Bianca, Strache, Nicole, Parchetka, Caroline, Artiges, Eric, Banaschewski, Tobias, Bokde, Arun, Bromberg, Uli, Buechel, Christian, Cattrell, Anna, Conrod, Patricia, Flor, Herta, Frouin, Vincent, Garavan, Hugh, Heinrich, Angela, Heinz, Andreas, Ittermann, Bernd, Jurk, Sarah, Lemaitre, Herve, Martinot, Jean-Luc, Mennigen, Eva, Martinot, Marie-Laure Paillère, Papadopoulos, Dimitri, Paus, Tomáš, Poustka, Luise, Smolka, Michael N., Vetter, Nora C., Walter, Henrik, Whelan, Rob, Schumann, Gunter, and Gallinat, Juergen

Published
2016
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26. New evidence of factor structure and measurement invariance of the SDQ across five European nations

Author

Ortuño-Sierra, Javier, Fonseca-Pedrero, Eduardo, Aritio-Solana, Rebeca, Velasco, Alvaro Moreno, de Luis, Edurne Chocarro, Schumann, Gunter, Cattrell, Anna, Flor, Herta, Nees, Frauke, Banaschewski, Tobias, Bokde, Arun, Whelan, Rob, Buechel, Christian, Bromberg, Uli, Conrod, Patricia, Frouin, Vincent, Papadopoulos, Dimitri, Gallinat, Juergen, Garavan, Hugh, Heinz, Andreas, Walter, Henrik, Struve, Maren, Gowland, Penny, Paus, Tomáš, Poustka, Luise, Martinot, Jean-Luc, Paillère-Martinot, Marie-Laure, Vetter, Nora C., Smolka, Michael N., Lawrence, Claire, and IMAGEN consortium

Published
2015
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27. The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium

Author

Bruin, Willem B., primary, Abe, Yoshinari, additional, Alonso, Pino, additional, Anticevic, Alan, additional, Balachander, Srinivas, additional, Bargallo, Nuria, additional, Batistuzzo, Marcelo Camargo, additional, Benedetti, Francesco, additional, Bertolín, Sara, additional, Brem, Silvia, additional, Calesella, Federico, additional, couto, beatriz, additional, Denys, Damiaan, additional, Echevarria, Marco A.N., additional, Eng, Goi Khia, additional, Ferreira, Sónia, additional, Feusner, Jamie, additional, Grazioplene, Rachael, additional, Gruner, Patricia, additional, Guo, Joyce Y., additional, Hagen, Kristen, additional, Hansen, Bjarne, additional, Hirano, Yoshiyuki, additional, Hoexter, Marcelo Queiroz, additional, Jahanshad, Neda, additional, Jaspers-Fayer, Fern, additional, Kasprzak, Selina, additional, Kim, Minah, additional, koch, kathrin, additional, Bin Kwak, Yoo, additional, Kwon, Jun Soo, additional, Lazaro, Luisa, additional, Li, Chiang-Shan R., additional, Lochner, Christine, additional, Marsh, Rachel, additional, Martínez-Zalacaín, Ignacio, additional, Menchon, Jose M., additional, Moreira, Pedro Silva, additional, Morgado, Pedro, additional, Nakagawa, Akiko, additional, Nakao, Tomohiro, additional, Narayanaswamy, Janardhanan C., additional, Nurmi, Erika L., additional, Zorrilla, Jose C. Pariente, additional, Piacentini, John, additional, Picó-Pérez, Maria, additional, Piras, Federica, additional, Piras, Fabrizio, additional, Pittenger, Christopher, additional, Reddy, Janardhan Y.C., additional, Rodriguez-Manrique, Daniela, additional, Sakai, Yuki, additional, Shimizu, Eiji, additional, Shivakumar, Venkataram, additional, Simpson, Blair H., additional, Soriano-Mas, Carles, additional, Sousa, Nuno, additional, Spalletta, Gianfranco, additional, Stern, Emily R., additional, Stewart, S. Evelyn, additional, Szeszko, Philip R., additional, Tang, Jinsong, additional, Thomopoulos, Sophia I, additional, Thorsen, Anders Lillevik, additional, Tokiko, Yoshida, additional, Tomiyama, Hirofumi, additional, Vai, Benedetta, additional, Veer, Ilya, additional, G, Venkatasubramanian, additional, Vetter, Nora C., additional, Vriend, Chris, additional, Walitza, Susanne, additional, Waller, Lea, additional, Wang, Zhen, additional, Watanabe, Anri, additional, Wolff, Nicole, additional, Yun, Je-Yeon, additional, Zhao, Qing, additional, van Leeuwen, Wieke A., additional, van Marle, Hein J.F., additional, van de Mortel, Laurens A., additional, van der Straten, Anouk, additional, van der Werf, Ysbrand, additional, Thompson, Paul, additional, Stein, Dan J., additional, van den Heuvel, Odile A., additional, and van Wingen, Guido, additional

Published
2022
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28. Is loss avoidance differentially rewarding in adolescents versus adults?: Differences in ventral striatum and anterior insula activation during the anticipation of potential monetary losses

Author

Bretzke, Maria, Vetter, Nora C., Kohls, Gregor, Wahl, Hannes, Roessner, Veit, Plichta, Michael M., Buse, Judith, Bretzke, Maria, Vetter, Nora C., Kohls, Gregor, Wahl, Hannes, Roessner, Veit, Plichta, Michael M., and Buse, Judith

Abstract

Avoiding loss is a crucial, adaptive guide to human behavior. While previous developmental research has primarily focused on gaining rewards, less attention has been paid to loss processing and its avoidance. In daily life, it is often unknown how likely an action will result in a loss, making the role of uncertainty in loss processing particularly important. By using functional magnetic resonance imaging, we investigated the influence of varying outcome probabilities (12%, 34%, and 67%) on brain regions implicated in loss processing (ventral striatum (VS), anterior insula (AI)) by comparing 28 adolescents (10–18 years) and 24 adults (22–32 years) during the anticipation of potential monetary loss. Overall, results revealed slower RTs in adolescents compared to adults with both groups being faster in the experimental (monetary condition) vs. control trials (verbal condition). Fastest RTs were observed for the 67% outcome probability in both age groups. An age group × outcome probability interaction effect revealed the greatest differences between the groups for the 12% vs. the 67% outcome probability. Neurally, both age groups demonstrated a higher percent signal change in the VS and AI during the anticipation of potential monetary loss versus the verbal condition. However, adults demonstrated an even greater activation of VS and AI than adolescents during the anticipation of potential monetary loss, but not during the verbal condition. This may indicate that adolescents differ from adults regarding their experience of avoiding losing monetary rewards.

Published
2022

29. Adolescent to young adult longitudinal development across 8 years for matching emotional stimuli during functional magnetic resonance imaging

Author

Vetter, Nora C., Fröhner, Juliane H., Hoffmann, Klara, Backhausen, Lea L., Smolka, Michael N., Vetter, Nora C., Fröhner, Juliane H., Hoffmann, Klara, Backhausen, Lea L., and Smolka, Michael N.

Abstract

We investigated development from adolescence to young adulthood of neural bottom-up and top-down processes using a functional magnetic resonance imaging task on emotional attention. We followed 249 participants from age 14–22 in up to four waves resulting in 687 total scans of a matching task in which participants decided whether two pictures were the same including distracting emotional or neutral scenes. We applied generalized additive mixed models and a reliability approach for longitudinal analysis. Reaction times and error rates decreased longitudinally. For top-down processing, we found a longitudinal increase for the bilateral inferior frontal gyrus (IFG) for negative stimuli and in the left IFG also for positive and neutral stimuli. For bottom-up activation in the bilateral amygdala, we found a relative stability for negative and neutral stimuli. For positive stimuli, there was an increase starting in the twenties. Results show ongoing behavioral and top-down prefrontal development relatively independent from emotional valence. Amygdala bottom-up activation remained stable except for positive stimuli. Current findings add to the sparse literature on longitudinal top-down and bottom-up development into young adulthood and emphasize the role of reliability. These findings might help to characterize healthy in contrast to dysfunctional development of emotional attention.

Published
2022

31. The role of the cannabinoid receptor in adolescents′ processing of facial expressions

Author

Ewald, Anais, Becker, Susanne, Heinrich, Angela, Banaschewski, Tobias, Poustka, Luise, Bokde, Arun, Büchel, Christian, Bromberg, Uli, Cattrell, Anna, Conrod, Patricia, Desrivières, Sylvane, Frouin, Vincent, Papadopoulos-Orfanos, Dimitri, Gallinat, Jürgen, Garavan, Hugh, Heinz, Andreas, Walter, Henrik, Ittermann, Bernd, Gowland, Penny, Paus, Tomáš, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Smolka, Michael N., Vetter, Nora, Whelan, Rob, Schumann, Gunter, Flor, Herta, Nees, Frauke, and OʼDoherty, John

Published
2016
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32. Is loss avoidance differentially rewarding in adolescents versus adults? Differences in ventral striatum and anterior insula activation during the anticipation of potential monetary losses.

Author

Bretzke, Maria, Vetter, Nora C., Kohls, Gregor, Wahl, Hannes, Roessner, Veit, Plichta, Michael M., and Buse, Judith

Subjects
*FUNCTIONAL magnetic resonance imaging, *HUMAN behavior, *TEENAGERS, *AGE groups, *EXPECTATION (Psychology), *INSULAR cortex
Abstract

Avoiding loss is a crucial, adaptive guide to human behavior. While previous developmental research has primarily focused on gaining rewards, less attention has been paid to loss processing and its avoidance. In daily life, it is often unknown how likely an action will result in a loss, making the role of uncertainty in loss processing particularly important. By using functional magnetic resonance imaging, we investigated the influence of varying outcome probabilities (12%, 34%, and 67%) on brain regions implicated in loss processing (ventral striatum (VS), anterior insula (AI)) by comparing 28 adolescents (10-18 years) and 24 adults (22-32 years) during the anticipation of potential monetary loss. Overall, results revealed slower RTs in adolescents compared to adults with both groups being faster in the experimental (monetary condition) vs. control trials (verbal condition). Fastest RTs were observed for the 67% outcome probability in both age groups. An age group outcome probability interaction effect revealed the greatest differences between the groups for the 12% vs. the 67% outcome probability. Neurally, both age groups demonstrated a higher percent signal change in the VS and AI during the anticipation of potential monetary loss versus the verbal condition. However, adults demonstrated an even greater activation of VS and AI than adolescents during the anticipation of potential monetary loss, but not during the verbal condition. This may indicate that adolescents differ from adults regarding their experience of avoiding losing monetary rewards. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Differential predictors for alcohol use in adolescents as a function of familial risk

Author

Tschorn, Mira, Lorenz, Robert C., O’Reilly, Paul F., Reichenberg, Abraham, Quinlan, Erin B., Flor, Herta, Grigis, Antoine, Garavan, Hugh, Ittermann, Bernd, Papadopoulos Orfanos, Dimitri, Poustka, Luise, Millenet, Sabina, Smolka, Michael N., Whelan, Robert, Schumann, Gunter, Rapp, Michael A., Robbins, Trevor, Dalley, Jeffrey, Subramaniam, Naresh, Theobald, David, Mann, Karl, Bach, Christiane, Struve, Maren, Banaschewski, Tobias, Rietschel, Marcella, Spanagel, Rainer, Nees, Frauke, Fauth-Bühler, Mira, Grimmer, Yvonne, Lathrop, Mark, Heinz, Andreas, Albrecht, Lisa, Ivanov, Nikolay, Strache, Nicole, Rapp, Michael, Ströhle, Andreas, Reuter, Jan, Gallinat, Jürgen, Walter, Henrik, Gemmeke, Isabel, Genauck, Alexander, Parchetka, Caroline, Weiß, Katharina, Kruschwitz, Johann, Raffaelli, Bianca, Isci, Alev, Daedelow, Laura, Barbot, Alexis, Thyreau, Benjamin, Schwartz, Yannick, Lalanne, Christophe, Frouin, Vincent, Orfanos, Dimitri Papadopoulos, Rogers, John, Ireland, James, Lanzerath, Dirk, Feng, Jianfeng, Martinot, Jean-Luc, Bricaud, Zuleima, Briand, Fanny Gollier, LemaÎtre, Hervé, Miranda, Ruben, Artiges, Eric, Massicotte, Jessica, Martinot, Marie-Laure Paillère, Vulser, Helene, Pentillä, Jani, Filippi, Irina, Galinowski, André, Bezivin, Pauline, Cattrell, Anna, Jia, Tianye, Desrivières, Sylvane, Werts, Helen, Topper, Lauren, Reed, Laurence, Andrew, Chris, Mallik, Catherine, Ruggeri, Barbara, Nymberg, Charlotte, Barker, Gareth, Conrod, Patricia J., Smith, Lindsay, Loth, Eva, Havatzias, Stephanie, Shekarrizi, Sheyda, Kitson, Emily, Robinson, Alice, Hall, Deborah, Rubino, Chiara, Wright, Hannah, Stueber, Kerstin, Hanratty, Eanna, Kennedy, Eleanor, De Carvahlo, Fabiana Mesquita, Stringaris, Argyris, Robert, Gabriel, Ing, Alex, Macare, Christine, Xu, Bing, Yu, Tao, Quinlan, Erin Burke, Constant, Patrick, Aydin, Semiha, Brühl, Ruediger, Ihlenfeld, Albrecht, Walaszek, Bernadeta, Smolka, Michael, Hübner, Thomas, Müller, Kathrin, Ripke, Stephan, Jurk, Sarah, Mennigen, Eva, Schmidt, Dirk, Vetter, Nora, Ziesch, Veronika, Fröhner, Juliane H., Bokde, Arun L. W., Carter, Daniel, Walsh, Emily, O’Driscoll, Susanne, Agan, Maria Leonora Fatimah, McMorrow, Mairead, Nugent, Sinead, Connolly, Colm, Dooley, Eoin, Cremen, Clodagh, Jones, Jennifer, O’Keefe, John, O’Connor, Martin, Poline, Jean-Baptiste, Büchel, Christian, Bromberg, Uli, Fadai, Tahmine, Yacubian, Juliana, Schneider, Sophia, Lobatchewa, Maria, Lawrence, Claire, Newman, Craig, Head, Kay, Heym, Nadja, Gowland, Penny, Stedman, Alicia, Kaviani, Mehri, Taplin, Susannah, Stephens, Dai, Paus, Tomáš, Pausova, Zdenka, Tahmasebi, Amir, Banaschewski, Tobias [0000-0003-4595-1144], Bokde, Arun L. W. [0000-0003-0114-4914], Quinlan, Erin B. [0000-0003-2927-1632], Desrivières, Sylvane [0000-0002-9120-7060], Gowland, Penny [0000-0002-4900-4817], Martinot, Jean-Luc [0000-0002-0136-0388], Artiges, Eric [0000-0003-4461-7646], Nees, Frauke [0000-0002-7796-8234], Papadopoulos Orfanos, Dimitri [0000-0002-1242-8990], Fröhner, Juliane H. [0000-0002-8493-6396], Smolka, Michael N. [0000-0001-5398-5569], Walter, Henrik [0000-0002-9403-6121], Heinz, Andreas [0000-0001-5405-9065], Rapp, Michael A. [0000-0003-0106-966X], and Apollo - University of Cambridge Repository

Subjects
631/208, article, 59/36, 45/23, 631/378, 631/477, 692/699/476/5
Abstract

Traditional models of future alcohol use in adolescents have used variable-centered approaches, predicting alcohol use from a set of variables across entire samples or populations. Following the proposition that predictive factors may vary in adolescents as a function of family history, we used a two-pronged approach by first defining clusters of familial risk, followed by prediction analyses within each cluster. Thus, for the first time in adolescents, we tested whether adolescents with a family history of drug abuse exhibit a set of predictors different from adolescents without a family history. We apply this approach to a genetic risk score and individual differences in personality, cognition, behavior (risk-taking and discounting) substance use behavior at age 14, life events, and functional brain imaging, to predict scores on the alcohol use disorders identification test (AUDIT) at age 14 and 16 in a sample of adolescents (N = 1659 at baseline, N = 1327 at follow-up) from the IMAGEN cohort, a longitudinal community-based cohort of adolescents. In the absence of familial risk (n = 616), individual differences in baseline drinking, personality measures (extraversion, negative thinking), discounting behaviors, life events, and ventral striatal activation during reward anticipation were significantly associated with future AUDIT scores, while the overall model explained 22% of the variance in future AUDIT. In the presence of familial risk (n = 711), drinking behavior at age 14, personality measures (extraversion, impulsivity), behavioral risk-taking, and life events were significantly associated with future AUDIT scores, explaining 20.1% of the overall variance. Results suggest that individual differences in personality, cognition, life events, brain function, and drinking behavior contribute differentially to the prediction of future alcohol misuse. This approach may inform more individualized preventive interventions.

Published
2021
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34. Cannabis-Associated Psychotic-like Experiences Are Mediated by Developmental Changes in the Parahippocampal Gyrus

Author

Yu, Tao, primary, Jia, Tianye, additional, Zhu, Liping, additional, Desrivières, Sylvane, additional, Macare, Christine, additional, Bi, Yan, additional, Bokde, Arun L.W., additional, Quinlan, Erin Burke, additional, Heinz, Andreas, additional, Ittermann, Bernd, additional, Liu, ChuanXin, additional, Ji, Lei, additional, Banaschewski, Tobias, additional, Ren, Decheng, additional, Du, Li, additional, Hou, Binyin, additional, Flor, Herta, additional, Frouin, Vincent, additional, Garavan, Hugh, additional, Gowland, Penny, additional, Martinot, Jean-Luc, additional, Paillère Martinot, Marie-Laure, additional, Nees, Frauke, additional, Orfanos, Dimitri Papadopoulos, additional, Luo, Qiang, additional, Chu, Congying, additional, Paus, Tomas, additional, Poustka, Luise, additional, Hohmann, Sarah, additional, Millenet, Sabina, additional, Smolka, Michael N., additional, Vetter, Nora C., additional, Mennigen, Eva, additional, Lei, Cai, additional, Walter, Henrik, additional, Fröhner, Juliane H., additional, Whelan, Robert, additional, He, Guang, additional, He, Lin, additional, Schumann, Gunter, additional, Robert, Gabriel, additional, Rapp, Michael, additional, Artiges, Eric, additional, Schneider, Sophia, additional, Bach, Christine, additional, Barbot, Alexis, additional, Barker, Gareth, additional, Bokde, Arun, additional, Vetter, Nora, additional, Büchel, Christian, additional, Cattrell, Anna, additional, Constant, Patrick, additional, Crombag, Hans, additional, Czech, Katharina, additional, Dalley, Jeffrey, additional, Decideur, Benjamin, additional, Spranger, Tade, additional, Ripley, Tamzin, additional, Heym, Nadja, additional, Sommer, Wolfgang, additional, Fuchs, Birgit, additional, Gallinat, Jürgen, additional, Spanagel, Rainer, additional, Kaviani, Mehri, additional, Heinrichs, Bert, additional, Subramaniam, Naresh, additional, Ihlenfeld, Albrecht, additional, Delosis, James Ireland, additional, Conrod, Patricia, additional, Jones, Jennifer, additional, Klaassen, Arno, additional, Lalanne, Christophe, additional, Lanzerath, Dirk, additional, Lawrence, Claire, additional, Lemaitre, Hervé, additional, Desrivieres, Sylvane, additional, Mallik, Catherine, additional, Mann, Karl, additional, Mar, Adam, additional, Martinez-Medina, Lourdes, additional, de Carvahlo, Fabiana Mesquita, additional, Schwartz, Yannick, additional, Bruehl, Ruediger, additional, Müller, Kathrin, additional, Nymberg, Charlotte, additional, Lathrop, Mark, additional, Robbins, Trevor, additional, Pausova, Zdenka, additional, Pentilla, Jani, additional, Biondo, Francesca, additional, Poline, Jean-Baptiste, additional, Smolka, Michael, additional, Fröhner, Juliane, additional, Struve, Maren, additional, Williams, Steve, additional, Hübner, Thomas, additional, Bromberg, Uli, additional, Aydin, Semiha, additional, Rogers, John, additional, Romanowski, Alexander, additional, Schmäl, Christine, additional, Schmidt, Dirk, additional, Ripke, Stephan, additional, Arroyo, Mercedes, additional, Schubert, Florian, additional, Pena-Oliver, Yolanda, additional, Fauth-Bühler, Mira, additional, Mignon, Xavier, additional, Speiser, Claudia, additional, Fadai, Tahmine, additional, Stephens, Dai, additional, Ströhle, Andreas, additional, Paillere, Marie-Laure, additional, Strache, Nicole, additional, Theobald, David, additional, Jurk, Sarah, additional, Vulser, Helene, additional, Miranda, Ruben, additional, Yacubilin, Juliana, additional, Genauck, Alexander, additional, Parchetka, Caroline, additional, Gemmeke, Isabel, additional, Kruschwitz, Johann, additional, WeiB, Katharina, additional, Feng, Jianfeng, additional, Papadopoulos, Dimitri, additional, Filippi, Irina, additional, Ing, Alex, additional, Ruggeri, Barbara, additional, Xu, Bing, additional, Hanratty, Eanna, additional, Yu, Tao, additional, Ziesch, Veronika, additional, and Stedman, Alicia, additional

Published
2020
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36. Rumpf ist Trumpf! Bewegungsgeschichten mit Fokus Gesundheit unter Bezugnahme der Bildung für Nachhaltige Entwicklung

Author

Vetter, Nora and Vetter, Nora

Abstract

Gesund bleiben ist stets ein bedeutsames Thema in der Volksschule. Die Schule spielt bei der Umsetzung von langfristigen und nationalen Gesundheitszielen, die auch in den Lehrplänen verankert sind, eine zentrale Rolle. In dieser praxisorien-tierten Bachelorarbeit wird der Frage nachgegangen, wie Bewegungsgeschichten gezielt die Gesundheit fördern und gleichzeitig nachhaltig einen Beitrag für die Ge-sundheit der Primarschulkinder leisten können. In der vorliegenden Arbeit werden der Bedeutung sowie der Begrifflichkeit von Ge-sundheitsförderung in Verbindung mit der Bildung für Nachhaltige Entwicklung (BNE) im Primarschulalter nachgegangen. Spezifische Merkmale von Bewegungs-geschichten werden mit Hilfe einer Analyse bereits vorhandener bewegungsanre-gender Erzählungen herausgearbeitet. Gesundheitsfördernde Aspekte werden ausgewählt und in selbst verfasste Geschichtskonstruktionen integriert. Zudem wird der Aufbau von Geschichten im Sinne des Storytelling aufgezeigt. Alle fünf Ge-schichten, die im Geschichtenbüchlein Rumpf ist Trumpf! zusammengefasst sind, basieren auf erarbeiteten theoretischen Grundlagen. Eine dazugehörige Spielbox dient als visuelle Unterstützungshilfe. Die Bewegungsgeschichten werden mit ver-schiedenen Sequenzen angereichert, mit dem Ziel der Bewusstmachung des The-mas und der Förderung des Körperbewusstseins. Damit sollen die Schülerinnen und Schüler bereits im Primarschulalter auf die Gesundheit aufmerksam gemacht werden und somit soll diesbezüglich Nachhaltigkeit generiert werden. Die Erpro-bung der Bewegungsgeschichten zeigt auf, dass Bewegungen nicht nur aktives Nachmachen bedeuten, sondern durch die reflexive Auseinandersetzung der eige-nen Bewegungsbiografie für das persönliche gesund bleiben sensibilisieren sollen.

Published
2021

37. Ventral striatal activation during reward anticipation of different reward probabilities in adolescents and adults

Author

Bretzke, Maria, Wahl, Hannes, Plichta, Michael M., Wolff, Nicole, Rößner, Veit, Vetter, Nora, Buse, Judith, Bretzke, Maria, Wahl, Hannes, Plichta, Michael M., Wolff, Nicole, Rößner, Veit, Vetter, Nora, and Buse, Judith

Abstract

Adolescence has been linked to an enhanced tolerance of uncertainty and risky behavior and is possibly connected to an increased response toward rewards. However, previous research has produced inconsistent findings. To investigate whether these findings are due to different reward probabilities used in the experimental design, we extended a monetary incentive delay (MID) task by including three different reward probabilities. Using functional magnetic resonance imaging, 25 healthy adolescents and 22 adults were studied during anticipation of rewards in the VS. Differently colored cue stimuli indicated either a monetary or verbal trial and symbolized different reward probabilities, to which the participants were blinded. Results demonstrated faster reaction times for lower reward probabilities (33%) in both age groups. Adolescents were slower through all conditions and had less activation on a neural level. Imaging results showed a three-way interaction between age group x condition x reward probability with differences in percent signal change between adolescents and adults for the high reward probabilities (66%, 88%) while adolescents demonstrated differences for the lowest (33%). Therefore, previous inconsistent findings could be due to different reward probabilities, which makes examining these crucial for a better understanding of adolescent and adult behavior.

Published
2021

43. Adolescent Basic Facial Emotion Recognition Is Not Influenced by Puberty or Own-Age Bias

Author

Vetter, Nora C., Drauschke, Mandy, Thieme, Juliane, and Altgassen, Mareike

Subjects
puberty, ddc:150, own-age bias, pubertal dip, Psychology, emotion, adolescence, adolescence, puberty, emotion, pubertal dip, own-age bias, development, Technische Universität Dresden, Publishing Fund, Adoleszenz, Pubertät, Emotion, Pubertät, Eigensucht, Entwicklung, Technische Universität Dresden, Publikationsfond, development, Original Research
Abstract

Basic facial emotion recognition is suggested to be negatively affected by puberty onset reflected in a “pubertal dip” in performance compared to pre- or post-puberty. However, findings remain inconclusive. Further, research points to an own-age bias, i.e., a superior emotion recognition for peer faces. We explored adolescents’ ability to recognize specific emotions. Ninety-five children and adolescents, aged 8–17 years, judged whether the emotions displayed by adolescent or adult faces were angry, sad, neutral, or happy. We assessed participants a priori by pubertal status while controlling for age. Results indicated no “pubertal dip”, but decreasing reaction times across adolescence. No own-age bias was found. Taken together, basic facial emotion recognition does not seem to be disrupted during puberty as compared to pre- and post-puberty.

Published
2018

45. Neuroimaging Evidence for Right Orbitofrontal Cortex Differences in Adolescents With Emotional and Behavioral Dysregulation

Author

Spechler, Philip A., primary, Chaarani, Bader, additional, Orr, Catherine, additional, Mackey, Scott, additional, Higgins, Stephen T., additional, Banaschewski, Tobias, additional, Bokde, Arun L.W., additional, Bromberg, Uli, additional, Büchel, Christian, additional, Quinlan, Erin Burke, additional, Conrod, Patricia J., additional, Desrivières, Sylvane, additional, Flor, Herta, additional, Frouin, Vincent, additional, Gowland, Penny, additional, Heinz, Andreas, additional, Ittermann, Bernd, additional, Martinot, Jean-Luc, additional, Nees, Frauke, additional, Orfanos, Dimitri Papadopoulos, additional, Poustka, Luise, additional, Fröhner, Juliane H., additional, Smolka, Michael N., additional, Walter, Henrik, additional, Whelan, Robert, additional, Schumann, Gunter, additional, Garavan, Hugh, additional, Althoff, Robert R., additional, Barker, Gareth, additional, Paillère Martinot, Marie-Laure, additional, Artiges, Eric, additional, Lemaitre, Herve, additional, Paus, Tomáš, additional, Vetter, Nora C., additional, Jurk, Sarah, additional, and Mennigen, Eva, additional

Published
2019
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47. Low Smoking Exposure, the Adolescent Brain, and the Modulating Role of CHRNA5 Polymorphisms

Author

Chaarani, Bader, primary, Kan, Kees-Jan, additional, Mackey, Scott, additional, Spechler, Philip A., additional, Potter, Alexandra, additional, Orr, Catherine, additional, D’Alberto, Nicholas, additional, Hudson, Kelsey E., additional, Banaschewski, Tobias, additional, Bokde, Arun L.W., additional, Bromberg, Uli, additional, Büchel, Christian, additional, Cattrell, Anna, additional, Conrod, Patricia J., additional, Desrivières, Sylvane, additional, Flor, Herta, additional, Frouin, Vincent, additional, Gallinat, Jürgen, additional, Gowland, Penny, additional, Heinz, Andreas, additional, Ittermann, Bernd, additional, Martinot, Jean-Luc, additional, Nees, Frauke, additional, Papadopoulos-Orfanos, Dimitri, additional, Paus, Tomáš, additional, Poustka, Luise, additional, Smolka, Michael N., additional, Walter, Henrik, additional, Whelan, Robert, additional, Higgins, Stephen T., additional, Schumann, Gunter, additional, Althoff, Robert R., additional, Stein, Elliot A., additional, Garavan, Hugh, additional, Mann, Karl, additional, Struve, Maren, additional, Rietschel, Marcella, additional, Spanagel, Rainer, additional, Fauth-Bühler, Mira, additional, Millenet, Sabina, additional, Grimmer, Yvonne, additional, Ivanov, Nikolay, additional, Strache, Nicole, additional, Rapp, Michael, additional, Ströhle, Andreas, additional, Reuter, Jan, additional, Barbot, Alexis, additional, Thyreau, Benjamin, additional, Schwartz, Yannick, additional, Lalanne, Christophe, additional, Bricaud, Zuleima, additional, Briand, Fanny Gollier, additional, Lemaitre, Hervé, additional, Massicotte, Jessica, additional, Vulser, Helene, additional, Pentillä, Jani, additional, Galinowski, André, additional, Jia, Tianye, additional, Werts, Helen, additional, Topper, Lauren, additional, Reed, Laurence, additional, Andrew, Chris, additional, Mallik, Catherine, additional, Ruggeri, Barbara, additional, Nymberg, Charlotte, additional, Smith, Lindsay, additional, Loth, Eva, additional, Havatzias, Stephanie, additional, Stueber, Kerstin, additional, Stringaris, Argyris, additional, Constant, Patrick, additional, Brühl, Ruediger, additional, Ihlenfeld, Albrecht, additional, Walaszek, Bernadeta, additional, Hübner, Thomas, additional, Müller, Kathrin, additional, Ripke, Stephan, additional, Rodehacke, Sarah, additional, Mennigen, Eva, additional, Schmidt, Dirk, additional, Vetter, Nora, additional, Ziesch, Veronika, additional, Jones, Jennifer, additional, Poline, Jean-Baptiste, additional, Fadai, Tahmine, additional, Yacubian, Juliana, additional, Schneider, Sophia, additional, Lawrence, Claire, additional, Newman, Craig, additional, Head, Kay, additional, Heym, Nadja, additional, Pausova, Zdenka, additional, and Tahmasebi, Amir, additional

Published
2019
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49. Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents

Author

Ruggeri, Barbara, Macare, Christine, Stopponi, Serena, Jia, Tianye, Carvalho, Fabiana M, Robert, Gabriel, Banaschewski, Tobias, Bokde, Arun L W, Bromberg, Uli, Büchel, Christian, Cattrell, Anna, Conrod, Patricia J, Desrivières, Sylvane, Flor, Herta, Frouin, Vincent, Gallinat, Jürgen, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean Luc, Martinot, Marie-Laure Paillère, Nees, Frauke, Papadopoulos-Orfanos, Dimitri, Paus, Tomáš, Poustka, Luise, Smolka, Michael N, Vetter, Nora C, Walter, Henrik, Whelan, Robert, Sommer, Wolfgang H, Bakalkin, Georgy, Ciccocioppo, Roberto, Schumann, Gunter, Ruggeri, Barbara, Macare, Christine, Stopponi, Serena, Jia, Tianye, Carvalho, Fabiana M, Robert, Gabriel, Banaschewski, Tobias, Bokde, Arun L W, Bromberg, Uli, Büchel, Christian, Cattrell, Anna, Conrod, Patricia J, Desrivières, Sylvane, Flor, Herta, Frouin, Vincent, Gallinat, Jürgen, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean Luc, Martinot, Marie-Laure Paillère, Nees, Frauke, Papadopoulos-Orfanos, Dimitri, Paus, Tomáš, Poustka, Luise, Smolka, Michael N, Vetter, Nora C, Walter, Henrik, Whelan, Robert, Sommer, Wolfgang H, Bakalkin, Georgy, Ciccocioppo, Roberto, and Schumann, Gunter

Abstract

BACKGROUND: Nociceptin is a key regulator linking environmental stress and alcohol drinking. In a genome-wide methylation analysis, we recently identified an association of a methylated region in the OPRL1 gene with alcohol-use disorders. METHODS: Here, we investigate the biological basis of this observation by analysing psychosocial stressors, methylation of the OPRL1 gene, brain response during reward anticipation and alcohol drinking in 660 fourteen-year-old adolescents of the IMAGEN study. We validate our findings in marchigian sardinian (msP) alcohol-preferring rats that are genetically selected for increased alcohol drinking and stress sensitivity. RESULTS: We found that low methylation levels in intron 1 of OPRL1 are associated with higher psychosocial stress and higher frequency of binge drinking, an effect mediated by OPRL1 methylation. In individuals with low methylation of OPRL1, frequency of binge drinking is associated with stronger BOLD response in the ventral striatum during reward anticipation. In msP rats, we found that stress results in increased alcohol intake and decreased methylation of OPRL1 in the nucleus accumbens. CONCLUSIONS: Our findings describe an epigenetic mechanism that helps to explain how psychosocial stress influences risky alcohol consumption and reward processing, thus contributing to the elucidation of biological mechanisms underlying risk for substance abuse.

Published
2018
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50. The impact of emotional congruent and emotional neutral context on recognizing complex emotions in older adults.

Author

Vetter, Nora C., Oosterman, Joukje M., Mühlbach, Jasmin, Wolff, Sina, and Altgassen, Mareike

Subjects
*OLDER people, *EMOTION recognition, *FILM excerpts, *YOUNG adults, *EMOTIONS
Abstract

Adding context information has been shown to attenuate the age-related decline of emotion recognition. Specifically, older adults might benefit from emotional congruent context information due to their greater social knowledge. Contrary, emotional neutral context information might impair older adults' performance more due to their decline of inhibitory abilities. Our aim was to examine the age-related decline of complex emotion recognition across three context conditions (emotional congruent, emotional neutral and no context). We hypothesized that emotional congruent context will help older adults to perform at the same level as younger adults and expected worse performance of older adults in the emotional neutral and no context conditions. Twenty-eight older and 28 younger adults watched film clips with complex emotions preceded by a fixation cross (no context), emotional congruent context or emotional neutral context. Emotional neutral context affected older adults' performance more negatively than young adults', whereas emotional congruent improved performance of both young and older adults to a similar extent. Results suggest that emotional congruent context does not eliminate the overall age-related deficit in complex emotion recognition. In contrast, this deficit might be intensified by emotional neutral context. [ABSTRACT FROM AUTHOR]

Published
2020
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