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1. Pesticide residues in European sediments: A significant concern for the aquatic systems?

Author

Khurshid, Chrow, Silva, Vera, Gai, Lingtong, Osman, Rima, Mol, Hans, Alaoui, Abdallah, Christ, Florian, Schlünssen, Vivi, Vested, Anne, Abrantes, Nelson, Campos, Isabel, Baldi, Isabelle, Robelot, Elsa, Bureau, Mathilde, Pasković, Igor, Polić Pasković, Marija, Glavan, Matjaž, Hofman, Jakub, Harkes, Paula, Huerta Lwanga, Esperanza, Norgaard, Trine, Ritsema, Coen J., and Geissen, Violette

Published
2024
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2. Identifying pesticides of high concern for ecosystem, plant, animal, and human health: A comprehensive field study across Europe and Argentina

Author

Alaoui, Abdallah, Christ, Florian, Silva, Vera, Vested, Anne, Schlünssen, Vivi, González, Neus, Gai, Lingtong, Abrantes, Nelson, Baldi, Isabelle, Bureau, Mathilde, Harkes, Paula, Norgaard, Trine, Navarro, Irene, de la Torre, Adrián, Sanz, Paloma, Martínez, María Ángeles, Hofman, Jakub, Pasković, Igor, Pasković, Marija Polić, Glavan, Matjaž, Lwanga, Esperanza Huerta, Aparicio, Virginia Carolina, Campos, Isabel, Alcon, Francisco, Contreras, Josefa, Mandrioli, Daniele, Sgargi, Daria, Scheepers, Paul T.J., Ritsema, Coen, and Geissen, Violette

Published
2024
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3. Assessing pesticide residues occurrence and risks in water systems: A Pan-European and Argentina perspective

Author

Navarro, Irene, de la Torre, Adrián, Sanz, Paloma, Abrantes, Nelson, Campos, Isabel, Alaoui, Abdallah, Christ, Florian, Alcon, Francisco, Contreras, Josefina, Glavan, Matjaž, Pasković, Igor, Pasković, Marija Polić, Nørgaard, Trine, Mandrioli, Daniele, Sgargi, Daria, Hofman, Jakub, Aparicio, Virginia, Baldi, Isabelle, Bureau, Mathilde, Vested, Anne, Harkes, Paula, Huerta-Lwanga, Esperanza, Mol, Hans, Geissen, Violette, Silva, Vera, and Martínez, María Ángeles

Published
2024
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4. Occurrence of pesticide residues in indoor dust of farmworker households across Europe and Argentina

Author

Navarro, Irene, de la Torre, Adrián, Sanz, Paloma, Baldi, Isabelle, Harkes, Paula, Huerta-Lwanga, Esperanza, Nørgaard, Trine, Glavan, Matjaž, Pasković, Igor, Pasković, Marija Polić, Abrantes, Nelson, Campos, Isabel, Alcon, Francisco, Contreras, Josefina, Alaoui, Abdallah, Hofman, Jakub, Vested, Anne, Bureau, Mathilde, Aparicio, Virginia, Mandrioli, Daniele, Sgargi, Daria, Mol, Hans, Geissen, Violette, Silva, Vera, and Martínez, María Ángeles

Published
2023
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5. Pesticide residues with hazard classifications relevant to non-target species including humans are omnipresent in the environment and farmer residences

Author

Silva, Vera, Gai, Lingtong, Harkes, Paula, Tan, Gaowei, Ritsema, Coen J., Alcon, Francisco, Contreras, Josefa, Abrantes, Nelson, Campos, Isabel, Baldi, Isabelle, Bureau, Mathilde, Christ, Florian, Mandrioli, Daniele, Sgargi, Daria, Pasković, Igor, Polić Pasković, Marija, Glavan, Matjaž, Hofman, Jakub, Huerta Lwanga, Esperanza, Norgaard, Trine, Bílková, Zuzana, Osman, Rima, Khurshid, Chrow, Navarro, Irene, de la Torre, Adrián, Sanz, Paloma, Ángeles Martínez, María, Dias, Jonatan, Mol, Hans, Gort, Gerrit, Martins Figueiredo, Daniel, Scheepers, Paul T.J., Schlünssen, Vivi, Vested, Anne, Alaoui, Abdallah, and Geissen, Violette

Published
2023
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8. Narrative review of occupational exposures and noncommunicable diseases

Author

Peters, Susan, Undem, Karina, Solovieva, Svetlana, Selander, Jenny, Schlünssen, Vivi, Oude Hengel, Karen M, Albin, Maria, Ge, Calvin B, Kjellberg, Katarina, McElvenny, Damien M, Gustavsson, Per, Kolstad, Henrik A, Würtz, Anne Mette L, Brinchmann, Bendik C, Broberg, Karin, Fossum, Stine, Bugge, Merete, Christensen, Mette Wulf, Ghosh, Manosij, Christiansen, David Høyrup, Merkus, Suzanne L, Lunde, Lars-Kristian, Viikari-Juntura, Eira, Dalbøge, Annett, Falkstedt, Daniel, Willert, Morten Vejs, Huss, Anke, Würtz, Else Toft, Dumas, Orianne, Iversen, Inge Brosbøl, Leite, Mimmi, Cramer, Christine, Kirkeleit, Jorunn, Svanes, Cecilie, Tinnerberg, Håkan, Garcia-Aymerich, Judith, Vested, Anne, Wiebert, Pernilla, Nordby, Karl-Christian, Godderis, Lode, Vermeulen, Roel, Pronk, Anjoeka, and Mehlum, Ingrid Sivesind

Published
2024
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10. Development of a quantitative North and Central European job exposure matrix for wood dust

Author

Basinas, Ioannis, primary, Liukkonen, Tuula, additional, Sigsgaard, Torben, additional, Andersen, Nils T, additional, Vestergaard, Jesper M, additional, Galea, Karen S, additional, van Tongeren, Martie, additional, Wiggans, Ruth, additional, Savary, Barbara, additional, Eduard, Wijnand, additional, Kolstad, Henrik A, additional, Vested, Anne, additional, Kromhout, Hans, additional, and Schlünssen, Vivi, additional

Published
2023
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11. Occurrence of Pesticide Residues in Indoor Dust of Farmworker Households Across Europe and Argentina

Author

NAVARRO, IRENE, primary, de la Torre, Adrián, additional, Sanz, Paloma, additional, Baldi, Isabelle, additional, Harkes, Paula, additional, Lwanga, Esperanza Huerta, additional, Nørgaard, Trine, additional, Glavan, Matjaž, additional, Pasković, Igor, additional, Pasković, Marija Polić, additional, Abrantes, Nelson, additional, Campos, Isabel, additional, Alcon, Francisco, additional, Contreras, Josefina, additional, Alaoui, Abdallah, additional, Hofman, Jakub, additional, Vested, Anne, additional, Bureau, Mathilde, additional, Aparicio, Virginia, additional, Mandrioli, Daniele, additional, Sgargi, Daria, additional, Mol, Hans, additional, Geissen, Violette, additional, Silva, Vera, additional, and Martínez, María Ángeles, additional

Published
2023
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12. Maternal Pre-pregnancy BMI and Reproductive Health of Daughters in Young Adulthood

Author

Mariansdatter, Saga Elise, Ernst, Andreas, Toft, Gunnar, Olsen, Sjurdur Frodi, Vested, Anne, Kristensen, Susanne Lund, Hansen, Mette Lausten, and Ramlau-Hansen, Cecilia Høst

Subjects
Reproductive health -- Analysis, Daughters -- Health aspects, Menarche -- Research, Pregnant women -- Health aspects -- Physiological aspects, Health care industry
Abstract

Objective To investigate the possible associations between maternal pre-pregnancy body mass index (BMI) and daughters' age of menarche and subsequent markers of reproductive health. Methods Nine hundred eighty-five pregnant women (80 %) were enrolled at their routine 30th week examinations in 1988-1989. In 2008, a follow-up questionnaire was completed for 365 daughters (83 %), while 267 daughters (61 %) participated in a subsequent clinical examination. Main outcome measures were age of menarche, reproductive hormone profile, and ovarian follicle count in daughters. Results Daughters of mothers in the highest pre-pregnancy BMI tertile (BMI [greater than or equal to] 22.0 kg/m.sup.2) had an adjusted 4.1 (0.3; 8.0) months earlier menarche compared with the middle tertile group (BMI 20.0-21.9 kg/m.sup.2). Among non-users of hormonal contraceptives, daughters of mothers in the highest pre-pregnancy BMI tertile had non-significantly lower dehydroepiandrosterone-sulphate (DHEAS), estradiol, and free estrogen index (FEI), compared to the middle BMI tertile. This was supported by a sub-analysis using the WHO classification (underweight, BMI < 18.50; normal range, BMI 18.50-24.99; overweight/obese, BMI [greater than or equal to] 25.00 kg/m.sup.2) as exposure groups, in which daughters of overweight mothers had lower levels of DHEAS and estradiol, and lower FEI compared to daughters of normal weight mothers. No associations were found for ovarian follicle count in any of the groups. Conclusions for Practice We found that higher maternal BMI is associated with earlier age of menarche in daughters. A possible impact of maternal pre-pregnancy BMI on DHEAS and estradiol serum levels, and FEI in non-users of hormonal contraceptives was indicated, but the results were not statistically significant., Author(s): Saga Elise Mariansdatter[sup.1] [sup.2] , Andreas Ernst[sup.1] , Gunnar Toft[sup.2] [sup.3] , Sjurdur Frodi Olsen[sup.4] , Anne Vested[sup.2] , Susanne Lund Kristensen[sup.2] , Mette Lausten Hansen[sup.2] , Cecilia Høst [...]

Published
2016
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13. Development of a quantitative North and Central European job exposure matrix for wood dust

Author

Basinas, Ioannis, Liukkonen, Tuula, Sigsgaard, Torben, Andersen, Nils T, Vestergaard, Jesper M, Galea, Karen S, van Tongeren, Martie, Wiggans, Ruth, Savary, Barbara, Eduard, Wijnand, Kolstad, Henrik A, Vested, Anne, Kromhout, Hans, and Schlünssen, Vivi

Abstract

Wood dust is an established carcinogen also linked to several non malignant respiratory disorders. A major limitation in research on wood dust and its health effects is the lack of (historical) quantitative estimates of occupational exposure for use in general population-based case-control or cohort studies. The present study aimed to develop a multinational quantitative Job Exposure Matrix (JEM) for wood dust exposure using exposure data from several Northern and Central European countries. For this, an occupational exposure database containing 12653 personal wood dust measurements collected between 1978 and 2007 in Denmark, Finland, France, The Netherlands, Norway, and the United Kingdom (UK) was established. Measurement data were adjusted for differences in inhalable dust sampling efficiency resulting from the use of different dust samplers and analysed using linear mixed effect regression with job codes (ISCO-88) and country treated as random effects. Fixed effects were the year of measurement, the expert assessment of exposure intensity (no, low, and high exposure) for every ISCO-88 job code from an existing wood dust JEM and sampling duration. The results of the models suggest that wood dust exposure has declined annually by approximately 8%. Substantial differences in exposure levels between countries were observed with the highest levels in the United Kingdom and the lowest in Denmark and Norway, albeit with similar job rankings across countries. The jobs with the highest predicted exposure are floor layers and tile setters, wood-products machine operators, and building construction labourers with geometric mean levels for the year 1997 between 1.7 and 1.9 mg/m3. The predicted exposure estimates by the model are compared with the results of wood dust measurement data reported in the literature. The model predicted estimates for full-shift exposures were used to develop a time-dependent quantitative JEM for exposure to wood dust that can be used to estimate exposure for participants of general population studies in Northern European countries on the health effects from occupational exposure to wood dust.

Published
2023
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16. Collection of human and environmental data on pesticide use in Europe and Argentina

Author

Silva, Vera, Alaoui, Abdallah, Schlünssen, Vivi, Vested, Anne, Graumans, Martien H.F., Dael, Maurice van, Trevisan, Marco, Suciu, Nicoleta, Mol, Hans, Glavan, Matjaž, Geissen, Violette, and Scheepers, Paul T. J.

Subjects
Evropa, okolje, pesticide residues, Argentina, udc:504.5, pesticides, fitofarmacevtska sredstva, human health, zdravje, ecotoxicology, Europe, ekotoksikologija, ostanki pesticidov, soil contaminants, pesticidi, agriculture
Abstract

Current farm systems rely on the use of Plant Protection Products (PPP) to secure high productivity and control threats to the quality of the crops. However, PPP use may have considerable impacts on human health and the environment. A study protocol is presented aiming to determine the occurrence and levels of PPP residues in plants (crops), animals (livestock), humans and other non-target species (ecosystem representatives) for exposure modelling and impact assessment. To achieve this, we designed a cross-sectional study to compare conventional and organic farm systems across Europe. Environmental and biological samples were/are being/will be collected during the 2021 growing season, at 10 case study sites in Europe covering a range of climate zones and crops. An additional study site in Argentina will inform the impact of PPP use on growing soybean which is an important European protein-source in animal feed. We will study the impact of PPP mixtures using an integrated risk assessment methodology. The fate of PPP in environmental media (soil, water and air) and in the homes of farmers will be monitored. This will be complemented by biomonitoring to estimate PPP uptake by humans and farm animals (cow, goat, sheep and chicken), and by collection of samples from non-target species (earthworms, fish, aquatic and terrestrial macroinvertebrates, bats, and farm cats). We will use data on PPP residues in environmental and biological matrices to estimate exposures by modelling. These exposure estimates together with health and toxicity data will be used to predict the impact of PPP use on environment, plant, animal and human health. The outcome of this study will then be integrated with socio-economic information leading to an overall assessment used to identify transition pathways towards more sustainable plant protection and inform decision makers, practitioners and other stakeholders regarding farming practices and land use policy.

Published
2021

17. A longitudinal study of morning, evening, and night light intensities and nocturnal sleep quality in a working population

Author

Amdisen, Lau, primary, Daugaard, Stine, additional, Vestergaard, Jesper Medom, additional, Vested, Anne, additional, Bonde, Jens Peter, additional, Vistisen, Helene Tilma, additional, Christoffersen, Jens, additional, Garde, Anne Helene, additional, Hansen, Åse Marie, additional, Markvart, Jakob, additional, Schlünssen, Vivi, additional, and Kolstad, Henrik Albert, additional

Published
2021
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19. O-211 Occupational daytime light exposure and risk of initiating antidepressant treatment among men and women: a national follow-up study

Author

Vested, Anne, primary, Schlünssen, Vivi, additional, Burdorf, Lex, additional, Flachs, Esben Meulengracht, additional, Daugaard, Stine, additional, Ellekilde Bonde, Jens Peter, additional, Peters, Susan, additional, Garde, Anne Helene, additional, Stokholm, Zara Ann, additional, Willert, Morten Vejs, additional, Vestergaard, Jesper Medom, additional, and Kolstad, Henrik Albert, additional

Published
2021
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20. Associations of in utero exposure to perfluorinated alkyl acids with human semen quality and reproductive hormones in adult men

Author

Vested, Anne, Ramlau-Hansen, Cecilia Host, Olsen, Sjurdur Frodi, Bonde, Jens Peter, Kristensen, Susanne Lund, Halldorsson, Thorhallur Ingi, Becher, Georg, Haug, Line Smastuen, Ernst, Emil Hagen, and Toft, Gunnar

Subjects
Ammonium perfluorooctanoate -- Health aspects, Semen -- Research, Men -- Physiological aspects, Environmental issues, Health
Abstract

BACKGROUND: Perfluorinated alkyl acids (PFAAs), persistent chemicals with unique water-, dirt-, and oil-repellent properties, are suspected of having endocrine-disrupting activity. The PFAA compounds perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid [...]

Published
2013

21. A longitudinal study of morning, evening, and night light intensities and nocturnal sleep quality in a working population.

Author

Amdisen, Lau, Daugaard, Stine, Vestergaard, Jesper Medom, Vested, Anne, Bonde, Jens Peter, Vistisen, Helene Tilma, Christoffersen, Jens, Garde, Anne Helene, Hansen, Åse Marie, Markvart, Jakob, Schlünssen, Vivi, and Kolstad, Henrik Albert

Subjects
SLEEP quality, SLEEP latency, LIGHT intensity, SLEEP, LONGITUDINAL method, BLUE light
Abstract

We aimed to investigate whether higher light intensity in the morning is associated with better nocturnal sleep quality and whether higher light intensities in the evening or night have the opposite effect. Light intensity was recorded for 7 consecutive days across the year among 317 indoor and outdoor daytime workers in Denmark (55–56° N) equipped with a personal light recorder. Participants reported sleep quality after each nocturnal sleep. Sleep quality was measured using three parameters; disturbed sleep index, awakening index, and sleep onset latency. Associations between increasing light intensities and sleep quality were analyzed using mixed effects models with participant identity as a random effect. Overall, neither white nor blue light intensities during morning, evening, or night were associated with sleep quality, awakening, or sleep onset latency of the subsequent nocturnal sleep. However, secondary analyses suggested that artificial light during the morning and day contrary to solar light may increase vulnerability to evening light exposure. Altogether, we were not able to confirm that higher morning light intensity significantly improves self-reported sleep quality or that higher evening or night light intensities impair self-reported sleep quality at exposure levels encountered during daily life in a working population in Denmark. This suggests that light intensities alone are not important for sleep quality to a degree that it is distinguishable from other important parameters in daily life settings. [ABSTRACT FROM AUTHOR]

Published
2022
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22. Dust exposure and the impact on hospital readmission of farming and wood industry workers for asthma and chronic obstructive pulmonary disease (COPD)

Author

Vested, Anne, primary, Kolstad, Henrik A, additional, Basinas, Ioannis, additional, Burdorf, Alex, additional, Elholm, Grethe, additional, Heederik, Dick, additional, Jacobsen, Gitte H, additional, Kromhout, Hans, additional, Omland, Øyvind, additional, Schaumburg, Inger, additional, Sigsgaard, Torben, additional, Vestergaard, Jesper M, additional, Wouters, Inge M, additional, and Schlünssen, Vivi, additional

Published
2020
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24. A Quantitative General Population Job Exposure Matrix for Occupational Daytime Light Exposure

Author

Vested, Anne, primary, Schlünssen, Vivi, additional, Burdorf, Alex, additional, Andersen, Johan H, additional, Christoffersen, Jens, additional, Daugaard, Stine, additional, Flachs, Esben M, additional, Garde, Anne Helene, additional, Hansen, Åse Marie, additional, Markvart, Jakob, additional, Peters, Susan, additional, Stokholm, Zara, additional, Vestergaard, Jesper M, additional, Vistisen, Helene T, additional, and Kolstad, Henrik Albert, additional

Published
2019
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25. O3A.6 Recent organic dust exposure and prognosis of asthma and chronic obstructive lung disease (COPD). A nationwide register based follow-up study

Author

Vested, Anne, primary, Basinas, Ioannis, additional, Burdorf, Alex, additional, Elholm, Grethe, additional, Heederik, Dick, additional, Jacobsen, Gitte, additional, Kolstad, Henrik, additional, Kromhout, Hans, additional, Omland, Øyvind, additional, Sigsgaard, Torben, additional, Vestergaard, Jesper Medom, additional, Wouters, Inge, additional, and Schlünssen, Vivi, additional

Published
2019
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26. A nationwide follow-up study of occupational organic dust exposure and risk of chronic obstructive pulmonary disease (COPD)

Author

Vested, Anne, primary, Basinas, Ioannis, additional, Burdorf, Alex, additional, Elholm, Grethe, additional, Heederik, Dick J J, additional, Jacobsen, Gitte H, additional, Kolstad, Henrik A, additional, Kromhout, Hans, additional, Omland, Øyvind, additional, Sigsgaard, Torben, additional, Thulstrup, Ane M, additional, Toft, Gunnar, additional, Vestergaard, Jesper M, additional, Wouters, Inge M, additional, and Schlünssen, Vivi, additional

Published
2018
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29. O26-4 Inverse associations between occupational organic dust exposure and incidence of chronic obstructive pulmonary disease (copd) – healthy worker survivor bias?

Author

Vested, Anne, primary, Basinas, Ioannis, additional, Heederik, Dick, additional, Jacobsen, Gitte, additional, Kolstad, Henrik, additional, Kromhout, Hans, additional, Omland, Øyvind, additional, Sigsgaard, Torben, additional, Toft, Gunnar, additional, Thulstrup, Ane Marie, additional, Vestergaard, Jesper, additional, Elholm, Grethe, additional, Wouters, M Inge, additional, and Schlünssen, Vivi, additional

Published
2016
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30. P096 Statistical modelling and development of a quantitative job exposure matrix for wood dust in the wood manufacturing industry

Author

Basinas, Ioannis, primary, Liukkonen, Tuula, additional, Sigsgaard, Torben, additional, Andersen, Nils T, additional, Vestergaard, Jesper M, additional, Galea, Karen, additional, Wiggans, Ruth, additional, Vincent, Raymond, additional, Eduard, Wijnand, additional, Kolstad, Henrik A, additional, Vested, Anne, additional, Kromhout, Hans, additional, and Schlünssen, Vivi, additional

Published
2016
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33. Occupational organic dust exposure and risk of chronic obstructive pulmonary disease (COPD) in Denmark

Author

Vested, Anne, primary, Basinas, Ioannis, additional, Toft, Gunnar, additional, Kromhout, Hans, additional, Sigsgaard, Torben, additional, Kolstad, Henrik Albert, additional, Thulstrup, Ane Marie, additional, Wouters, Inge, additional, Heederik, Dick, additional, Omland, Øyvind, additional, Jacobsen, Gitte, additional, and Schlünssen, Vivi, additional

Published
2015
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36. MCAD deficiency in Denmark

Author

Andresen, Brage Storstein, primary, Lund, Allan Meldgaard, additional, Hougaard, David Michael, additional, Christensen, Ernst, additional, Gahrn, Birthe, additional, Christensen, Mette, additional, Bross, Peter, additional, Vested, Anne, additional, Simonsen, Henrik, additional, Skogstrand, Kristin, additional, Olpin, Simon, additional, Brandt, Niels Jacob, additional, Skovby, Flemming, additional, Nørgaard-Pedersen, Bent, additional, and Gregersen, Niels, additional

Published
2012
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43. Collection of human and environmental data on pesticide use in Europe and Argentina: Field study protocol for the SPRINT project

Author

Silva, Vera, Alaoui, Abdallah, Schlünssen, Vivi, Vested, Anne, Graumans, Martien, Van Dael, Maurice, Trevisan, Marco, Suciu, Nicoleta, Mol, Hans, Beekmann, Karsten, Figueiredo, Daniel, Harkes, Paula, Hofman, Jakub, Kandeler, Ellen, Abrantes, Nelson, Campos, Isabel, Martínez, María Ángeles, Pereira, Joana Luísa, Goossens, Dirk, Gandrass, Juergen, Debler, Freya, Lwanga, Esperanza Huerta, Jonker, Marlot, Van Langevelde, Frank, Sorensen, Martin T, Wells, Jerry M, Boekhorst, Jos, Huss, Anke, Mandrioli, Daniele, Sgargi, Daria, Nathanail, Paul, Nathanail, Judith, Tamm, Lucius, Fantke, Peter, Mark, Jennifer, Grovermann, Christian, Frelih-Larsen, Ana, Herb, Irina, Chivers, Charlotte-Anne, Mills, Jane, Alcon, Francisco, Contreras, Josefina, Baldi, Isabelle, Pasković, Igor, Matjaz, Glavan, Norgaard, Trine, Aparicio, Virginia, Ritsema, Coen J, Geissen, Violette, and Scheepers, Paul TJ

Subjects
2. Zero hunger, Crops, Agricultural, Europe, 13. Climate action, Argentina, Animals, Humans, 15. Life on land, Pesticides, 6. Clean water, Ecosystem, 12. Responsible consumption
Abstract

Current farm systems rely on the use of Plant Protection Products (PPP) to secure high productivity and control threats to the quality of the crops. However, PPP use may have considerable impacts on human health and the environment. A study protocol is presented aiming to determine the occurrence and levels of PPP residues in plants (crops), animals (livestock), humans and other non-target species (ecosystem representatives) for exposure modelling and impact assessment. To achieve this, we designed a cross-sectional study to compare conventional and organic farm systems across Europe. Environmental and biological samples were/are being/will be collected during the 2021 growing season, at 10 case study sites in Europe covering a range of climate zones and crops. An additional study site in Argentina will inform the impact of PPP use on growing soybean which is an important European protein-source in animal feed. We will study the impact of PPP mixtures using an integrated risk assessment methodology. The fate of PPP in environmental media (soil, water and air) and in the homes of farmers will be monitored. This will be complemented by biomonitoring to estimate PPP uptake by humans and farm animals (cow, goat, sheep and chicken), and by collection of samples from non-target species (earthworms, fish, aquatic and terrestrial macroinvertebrates, bats, and farm cats). We will use data on PPP residues in environmental and biological matrices to estimate exposures by modelling. These exposure estimates together with health and toxicity data will be used to predict the impact of PPP use on environment, plant, animal and human health. The outcome of this study will then be integrated with socio-economic information leading to an overall assessment used to identify transition pathways towards more sustainable plant protection and inform decision makers, practitioners and other stakeholders regarding farming practices and land use policy.

44. Collection of human and environmental data on pesticide use in Europe and Argentina: Field study protocol for the SPRINT project

Author

Silva, Vera, Alaoui, Abdallah, Schl��nssen, Vivi, Vested, Anne, Graumans, Martien, van Dael, Maurice, Trevisan, Marco, Suciu, Nicoleta, Mol, Hans, Beekmann, Karsten, Figueiredo, Daniel, Harkes, Paula, Hofman, Jakub, Kandeler, Ellen, Abrantes, Nelson, Campos, Isabel, ��ngeles Mart��nez, Mar��a, Lu��sa Pereira, Joana, Goossens, Dirk, Gandrass, Juergen, Debler, Freya, Huerta Lwanga, Esperanza, Jonker, Marlot, van Langevelde, Frank, Sorensen, Martin T., Wells, Jerry M., Boekhorst, Jos, Huss, Anke, Mandrioli, Daniele, Sgargi, Daria, Nathanail, Paul, Nathanail, Judith, Tamm, Lucius, Fantke, Peter, Mark, Jennifer, Grovermann, Christian, Frelih-Larsen, Ana, Herb, Irina, Chivers, Charlotte-Anne, Mills, Jane, Alcon, Francisco, Contreras, Josefina, Baldi, Isabelle, Paskovi��, Igor, Matjaz, Glavan, Norgaard, Trine, Aparicio, Virginia, Ritsema, Coen J., Geissen, Violette, and Scheepers, Paul T. J.

Subjects
2. Zero hunger, 13. Climate action, 550 Earth sciences & geology, 910 Geography & travel, 15. Life on land, 6. Clean water, 12. Responsible consumption
Abstract

Current farm systems rely on the use of Plant Protection Products (PPP) to secure high productivity and control threats to the quality of the crops. However, PPP use may have considerable impacts on human health and the environment. A study protocol is presented aiming to determine the occurrence and levels of PPP residues in plants (crops), animals (livestock), humans and other non-target species (ecosystem representatives) for exposure modelling and impact assessment. To achieve this, we designed a cross-sectional study to compare conventional and organic farm systems across Europe. Environmental and biological samples were/are being/will be collected during the 2021 growing season, at 10 case study sites in Europe covering a range of climate zones and crops. An additional study site in Argentina will inform the impact of PPP use on growing soybean which is an important European protein-source in animal feed. We will study the impact of PPP mixtures using an integrated risk assessment methodology. The fate of PPP in environmental media (soil, water and air) and in the homes of farmers will be monitored. This will be complemented by biomonitoring to estimate PPP uptake by humans and farm animals (cow, goat, sheep and chicken), and by collection of samples from non-target species (earthworms, fish, aquatic and terrestrial macroinvertebrates, bats, and farm cats). We will use data on PPP residues in environmental and biological matrices to estimate exposures by modelling. These exposure estimates together with health and toxicity data will be used to predict the impact of PPP use on environment, plant, animal and human health. The outcome of this study will then be integrated with socio-economic information leading to an overall assessment used to identify transition pathways towards more sustainable plant protection and inform decision makers, practitioners and other stakeholders regarding farming practices and land use policy.

45. Narrative review of occupational exposures and noncommunicable diseases.

Author

Peters S, Undem K, Solovieva S, Selander J, Schlünssen V, Oude Hengel KM, Albin M, Ge CB, Kjellberg K, McElvenny DM, Gustavsson P, Kolstad HA, Würtz AML, Brinchmann BC, Broberg K, Fossum S, Bugge M, Christensen MW, Ghosh M, Christiansen DH, Merkus SL, Lunde LK, Viikari-Juntura E, Dalbøge A, Falkstedt D, Willert MV, Huss A, Würtz ET, Dumas O, Iversen IB, Leite M, Cramer C, Kirkeleit J, Svanes C, Tinnerberg H, Garcia-Aymerich J, Vested A, Wiebert P, Nordby KC, Godderis L, Vermeulen R, Pronk A, and Mehlum IS

Subjects
Humans, Risk Factors, Cardiovascular Diseases etiology, Cardiovascular Diseases epidemiology, Musculoskeletal Diseases etiology, Musculoskeletal Diseases epidemiology, Occupational Diseases epidemiology, Occupational Diseases etiology, Neurodegenerative Diseases etiology, Neurodegenerative Diseases epidemiology, Respiratory Tract Diseases epidemiology, Respiratory Tract Diseases etiology, Exposome, Mental Disorders epidemiology, Mental Disorders etiology, Occupational Exposure adverse effects, Occupational Exposure statistics & numerical data, Occupational Exposure analysis, Noncommunicable Diseases epidemiology, Neoplasms epidemiology, Neoplasms etiology
Abstract

Objective: Within the scope of the Exposome Project for Health and Occupational Research on applying the exposome concept to working life health, we aimed to provide a broad overview of the status of knowledge on occupational exposures and associated health effects across multiple noncommunicable diseases (NCDs) to help inform research priorities., Methods: We conducted a narrative review of occupational risk factors that can be considered to have "consistent evidence for an association," or where there is "limited/inadequate evidence for an association" for 6 NCD groups: nonmalignant respiratory diseases; neurodegenerative diseases; cardiovascular/metabolic diseases; mental disorders; musculoskeletal diseases; and cancer. The assessment was done in expert sessions, primarily based on systematic reviews, supplemented with narrative reviews, reports, and original studies. Subsequently, knowledge gaps were identified, e.g. based on missing information on exposure-response relationships, gender differences, critical time-windows, interactions, and inadequate study quality., Results: We identified over 200 occupational exposures with consistent or limited/inadequate evidence for associations with one or more of 60+ NCDs. Various exposures were identified as possible risk factors for multiple outcomes. Examples are diesel engine exhaust and cadmium, with consistent evidence for lung cancer, but limited/inadequate evidence for other cancer sites, respiratory, neurodegenerative, and cardiovascular diseases. Other examples are physically heavy work, shift work, and decision latitude/job control. For associations with limited/inadequate evidence, new studies are needed to confirm the association. For risk factors with consistent evidence, improvements in study design, exposure assessment, and case definition could lead to a better understanding of the association and help inform health-based threshold levels., Conclusions: By providing an overview of knowledge gaps in the associations between occupational exposures and their health effects, our narrative review will help setting priorities in occupational health research. Future epidemiological studies should prioritize to include large sample sizes, assess exposures prior to disease onset, and quantify exposures. Potential sources of biases and confounding need to be identified and accounted for in both original studies and systematic reviews., (© The Author(s) 2024. Published by Oxford University Press on behalf of the British Occupational Hygiene Society.)

Published
2024
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