13 results on '"Vesel M"'
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2. Personalized guiding templates for pedicle screw placement
- Author
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Tominc, U., primary, Vesel, M., additional, Mawed, S. Al, additional, Dobravec, M., additional, Jug, M., additional, Herman, S., additional, and Kreuh, D., additional
- Published
- 2014
- Full Text
- View/download PDF
3. Supergene processes on ore deposits?a source of heavy metals
- Author
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Martyc�k, K., primary, Zeman, J., additional, and Vacek-Vesel�, M., additional
- Published
- 1994
- Full Text
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4. Serum Gastrin and Mucosal Somatostatin in Helicobacter pylori-Associated Gastritis.
- Author
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Götz, J. M., Veenendaal, R. A., Biemond, I., Muller, E. S. M., Vesel, M., and Lamers, C. B. H. W.
- Published
- 1995
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5. Angular Stable Plates in Lower Cervical Spine Fractures
- Author
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Vesel, M., Straus, I., Al Mawed, S., Dobravec, M., and Jug, M.
- Published
- 2006
- Full Text
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6. Schola ludus, serious games, and measurement of interestingness.
- Author
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Ferko, A., Cernekova, Z., Dadova, J., Major, V., Onacilova, D., Sikudova, E., Svarba, R., Valikova, M., Varhanikova, I., Vataha, M., Vesel, M., and Duskova, E.
- Published
- 2011
- Full Text
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7. Acute Cartilage Injury Induced by Trans-Articular Sutures.
- Author
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Ciglič M, Marš T, Maružin M, Alibegović A, Vesel M, and Drobnič M
- Subjects
- Humans, Wound Healing, Cartilage injuries, Polydioxanone, Polyglactin 910, Sutures adverse effects
- Abstract
Objective: To determine the extent of acute cartilage injury by using trans-articular sutures., Methods: Five different absorbable sutures, monofilament polydioxanone (PDS) and braided polyglactin (Vicryl), were compared on viable human osteochondral explants. An atraumatic needle with 30 cm of thread was advanced through the cartilage with the final thread left in the tissue. A representative 300 μm transversal slice from the cartilage midportion was stained with Live/Dead probes, scanned under the confocal laser microscope, and analyzed for the diameters of (a) central "Black zone" without any cells, representing in situ thread thickness and (b) "Green zone," including the closest Live cells, representing the maximum injury to the tissue. The exact diameters of suture needles and threads were separately measured under an optical microscope., Results: The diameters of the Black (from 144 to 219 µm) and the Green zones (from 282 to 487 µm) varied between the different sutures ( P < 0.001). The Green/Black zone ratio remained relatively constant (from 1.9 to 2.2; P = 0.767). A positive correlation between thread diameters and PDS suturing material, toward the Black and Green zone, was established, but needle diameters did not reveal any influence on the zones., Conclusions: The width of acute cartilage injury induced by the trans-articular sutures is about twice the thread thickness inside of the tissue. Less compressible monofilament PDS induced wider tissue injury in comparison to a softer braided Vicryl. Needle diameter did not correlate to the extent of acute cartilage injury.
- Published
- 2021
- Full Text
- View/download PDF
8. KRAS and EGFR Mutations Differentially Alter ABC Drug Transporter Expression in Cisplatin-Resistant Non-Small Cell Lung Cancer.
- Author
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Jaromi L, Csongei V, Vesel M, Abdelwahab EMM, Soltani A, Torok Z, Smuk G, Sarosi V, and Pongracz JE
- Subjects
- A549 Cells, Aged, Carcinoma, Non-Small-Cell Lung drug therapy, Cell Line, Cell Line, Tumor, Cisplatin pharmacology, ErbB Receptors genetics, Female, Gene Expression genetics, Human Umbilical Vein Endothelial Cells, Humans, Lung Neoplasms drug therapy, Male, Middle Aged, Tumor Microenvironment genetics, ATP-Binding Cassette Transporters genetics, Carcinoma, Non-Small-Cell Lung genetics, Drug Resistance, Multiple genetics, Drug Resistance, Neoplasm genetics, Lung Neoplasms genetics, Mutation genetics, Proto-Oncogene Proteins p21(ras) genetics
- Abstract
Lung carcinoma is still the most common malignancy worldwide. One of the major subtypes of non-small cell lung cancer (NSCLC) is adenocarcinoma (AC). As driver mutations and hence therapies differ in AC subtypes, we theorized that the expression and function of ABC drug transporters important in multidrug resistance (MDR) would correlate with characteristic driver mutations KRAS or EGFR. Cisplatin resistance (CR) was generated in A549 (KRAS) and PC9 (EGFR) cell lines and gene expression was tested. In three-dimensional (3D) multicellular aggregate cultures, both ABCB1 and ABCG2 transporters, as well as the WNT microenvironment, were investigated. ABCB1 and ABCG2 gene expression levels were different in primary AC samples and correlated with specific driver mutations. The drug transporter expression pattern of parental A549 and PC9, as well as A549-CR and PC9-CR, cell lines differed. Increased mRNA levels of ABCB1 and ABCG2 were detected in A549-CR cells, compared to parental A549, while the trend observed in the case of PC9 cells was different. Dominant alterations were observed in LEF1, RHOU and DACT1 genes of the WNT signalling pathway in a mutation-dependent manner. The study confirmed that, in lung AC-s, KRAS and EGFR driver mutations differentially affect both drug transporter expression and the cisplatin-induced WNT signalling microenvironment.
- Published
- 2021
- Full Text
- View/download PDF
9. Can telerehabilitation games lead to functional improvement of upper extremities in individuals with Parkinson's disease?
- Author
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Cikajlo I, Hukić A, Dolinšek I, Zajc D, Vesel M, Krizmanič T, Blažica B, Biasizzo A, Novak F, and Peterlin Potisk K
- Subjects
- Aged, Disability Evaluation, Female, Humans, Male, Parkinson Disease physiopathology, Parkinson Disease rehabilitation, Telerehabilitation methods, Upper Extremity physiopathology, Video Games
- Abstract
Parkinson's disease (PD) is treated by medication, less with deep brain stimulation and physiotherapy. Different opinions on the clinical meaningfulness of the physiotherapy or recommended intensive physiotherapy were found. Our objectives were to design intensive target-based physiotherapy for upper extremities suitable for telerehabilitation services and examine the clinical meaningfulness of the exergaming at an unchanged medication plan. A telerehabilitation exergaming system using the Kinect sensor was developed; 28 patients with PD participated in the study. The system followed the participants' movements and adapted the difficulty level of the game in real time. The outcomes of the study showed that seven out of 26 participants could set up the equipment at home alone. Clinical outcomes of Box and Blocks Test (mean: 47 vs. 52, P=0.002, Cohen's d=0.40), UPDRS III (mean: 27 vs. 29, P=0.001, d=0.22), and daily activity Jebsen's test; writing a letter (mean: 24.0 vs. 20.6, P=0.003, d=0.23); and moving light objects (mean: 4.4 vs. 3.9, P=0.006, d=0.46) were statistically significant (P<0.05) and considered clinically meaningful. The Nine-Hole Peg Test showed a statistically nonsignificant improvement (mean: 28.0 vs. 26.5, P=0.089, d=0.22). The participants claimed problems with mobility but less with activities of daily living and emotional well-being (PDQ-39). The findings lead to preliminary conclusions that exergaming is feasible, but may require technical assistance, whereas clinically meaningful results could be achieved according to validated instruments and an unchanged medication plan in individuals with PD.
- Published
- 2018
- Full Text
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10. Hyperbaric oxygenation and 20-hydroxyeicosatetreanoic acid inhibition reduce stroke volume in female diabetic Sprague-Dawley rats.
- Author
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Mišir M, Renić M, Novak S, Mihalj M, Ćosić A, Vesel M, and Drenjančević I
- Subjects
- Animals, Aryl Hydrocarbon Hydroxylases genetics, Aryl Hydrocarbon Hydroxylases metabolism, Brain metabolism, Brain pathology, Combined Modality Therapy, Cytochrome P-450 Enzyme System genetics, Cytochrome P-450 Enzyme System metabolism, Cytochrome P450 Family 2 genetics, Cytochrome P450 Family 2 metabolism, Cytochrome P450 Family 4 genetics, Cytochrome P450 Family 4 metabolism, Diabetes Mellitus, Experimental metabolism, Diabetes Mellitus, Experimental physiopathology, Diabetes Mellitus, Type 1 metabolism, Diabetes Mellitus, Type 1 physiopathology, Epoxide Hydrolases genetics, Epoxide Hydrolases metabolism, Female, Gene Expression Regulation, Enzymologic, Infarction, Middle Cerebral Artery metabolism, Infarction, Middle Cerebral Artery pathology, Infarction, Middle Cerebral Artery physiopathology, Nitric Oxide Synthase Type III genetics, Nitric Oxide Synthase Type III metabolism, RNA, Messenger genetics, RNA, Messenger metabolism, Rats, Sprague-Dawley, Reperfusion Injury metabolism, Reperfusion Injury pathology, Reperfusion Injury physiopathology, Steroid 16-alpha-Hydroxylase genetics, Steroid 16-alpha-Hydroxylase metabolism, Time Factors, Amidines pharmacology, Brain drug effects, Diabetes Mellitus, Experimental therapy, Diabetes Mellitus, Type 1 therapy, Hydroxyeicosatetraenoic Acids metabolism, Hyperbaric Oxygenation, Infarction, Middle Cerebral Artery therapy, Neuroprotective Agents pharmacology, Reperfusion Injury prevention & control
- Abstract
New Findings: What is the central question of this study? Is there a beneficial effect and what are the mechanisms of acute and multiple hyperbaric oxygenation (HBO
2 ) exposures on the outcome of cerebral tissue injury induced by a transient middle cerebral artery occlusion model in diabetic female rats? Are 20-hydroxyeicosatetreanoic acid and epoxyeicosatrienoic acids involved? What is the main finding and its importance? Equal reduction of cortical and total infarct size in rats treated with HBO2 and HET0016 (20-hydroxyeicosatetreanoic acid production inhibitor) and significant mRNA upregulation of epoxyeicosatrienoic acid-producing enzymes (Cyp2J3 and Cyp2C11) in treated groups suggest that HBO2 and HET0016 are highly effective stroke treatments and that cytochrome P450 metabolites are involved in this therapeutic effect. We evaluated the effects of acute and repetitive hyperbaric oxygenation (HBO2 ), 20-hydroxyeicosatetreanoic acid (20-HETE) inhibition by N-hydroxy-N'-(4-butyl-2methylphenyl)-formamidine (HET0016) and their combination on experimental stroke outcomes. Streptozotocin-induced type 1 diabetic Sprague-Dawley female rats (n = 42; n = 7 per group), were subjected to 30 min of transient middle cerebral artery occlusion (t-MCAO)-reperfusion and divided into the following groups: (1) control group, without treatment; and groups exposed to: (2) HBO2 ; (3) multiple HBO2 (HBO2 immediately and second exposure 12 h after t-MCAO); (4) HET0016 pretreatment (1 mg kg-1 , 3 days before t-MCAO) combined with HBO2 after t-MCAO; (5) HET0016 treatment (1 h before, during and for 6 h after t-MCAO); and (6) HET0016 treatment followed by HBO2 after t-MCAO. Messenger RNA expression of CYP2J3, CYP2C11, CYP4A1, endothelial nitric oxide synthase and epoxide hydrolase 2 was determined by real-time qPCR. Cortical infarct size and total infarct size were equally and significantly reduced in HBO2 - and HET0016-treated rats. Combined treatment with HET0016 and HBO2 provided no significant additive effect compared with HET0016 treatment only. Messenger RNA of Cyp2J3 was significantly increased in all study groups, and mRNA of Cyp2C11 was significantly increased in the multiple HBO2 group and the HET0016 treatment followed by HBO2 group, compared with the control group. Expression of endothelial nitric oxide synthase was significantly increased after HBO2 treatments, and expression of epoxide hydrolase 2 was increased in all groups compared with the control group. In diabetic female Sprague-Dawley rats, HBO2 and HET0016 are highly effective stroke treatments, suggesting the involvement of cytochrome P450 metabolites and the NO pathway in this therapeutic effect., (© 2017 The Authors. Experimental Physiology © 2017 The Physiological Society.)- Published
- 2017
- Full Text
- View/download PDF
11. Reduced Dietary Selenium Impairs Vascular Function by Increasing Oxidative Stress in Sprague-Dawley Rat Aortas.
- Author
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Stupin A, Cosic A, Novak S, Vesel M, Jukic I, Popovic B, Karalic K, Loncaric Z, and Drenjancevic I
- Subjects
- Animal Feed, Animals, Arginine analogs & derivatives, Gene Expression Regulation, Enzymologic drug effects, Male, Nitric Oxide metabolism, Rats, Rats, Sprague-Dawley, Selenium administration & dosage, Aorta drug effects, Diet, Endothelium, Vascular drug effects, Oxidative Stress drug effects, Selenium pharmacology
- Abstract
This study aimed to determine whether low dietary Se content affects the function and mechanisms mediating the vascular relaxation of rat aortas, and to test the role of oxidative stress in observed differences. Male Sprague Dawley (SD) rats were maintained for 10 weeks on low Se (low-Se group; N = 20) or normal Se content (norm-Se group; N = 20) rat chow. Dose responses to acetylcholine (ACh; 10
-9 -10-5 M) and the response to reduced pO₂ were tested in noradrenaline-precontracted aortic rings in the absence/presence of the nitric oxide synthase (NOS) inhibitor nitro-l-arginine methyl ester (l-NAME), the cyclooxygenase 1 and 2 (COX-1, 2) inhibitor Indomethacin, and the antioxidative agent Tempol in tissue bath. mRNA expression of glutathione peroxidase 1 (GPx1), catalase (CAT), and Cu/Zn superoxide dismutase (SOD) was measured in rat aortas. Oxidative stress (Thiobarbituric Acid Reactive Substances; TBARS), antioxidative plasma capacity (ferric reducing ability of plasma assay; FRAP), and protein levels of GPx1 were measured in plasma and serum samples, respectively. Reduced ACh-induced relaxation (AChIR) (dominantly mediated by NO) in the low-Se group compared to the norm-Se group was restored by Tempol administration. Hypoxia-induced relaxation (HIR) (dominantly mediated by COX-1, 2), TBARS, and FRAP as well as GPx1 serum concentrations were similar between the groups. mRNA GPx1 expression in rat aortas was significantly decreased in the low-Se compared to the norm-Se group. These data suggest that low dietary Se content increases the local oxidative stress level, which subsequently affects the NO-mediated vascular response.- Published
- 2017
- Full Text
- View/download PDF
12. Neurological Recovery after Traumatic Cervical Spinal Cord Injury Is Superior if Surgical Decompression and Instrumented Fusion Are Performed within 8 Hours versus 8 to 24 Hours after Injury: A Single Center Experience.
- Author
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Jug M, Kejžar N, Vesel M, Al Mawed S, Dobravec M, Herman S, and Bajrović FF
- Subjects
- Adult, Aged, Aged, 80 and over, Cohort Studies, Decompression, Surgical adverse effects, Female, Follow-Up Studies, Humans, Internal Fixators, Length of Stay, Male, Middle Aged, Neurosurgical Procedures adverse effects, Postoperative Complications epidemiology, Prospective Studies, Respiration, Artificial, Spinal Cord Compression, Spinal Cord Injuries mortality, Treatment Outcome, Cervical Vertebrae injuries, Decompression, Surgical methods, Neurosurgical Procedures methods, Recovery of Function, Spinal Cord Injuries physiopathology, Spinal Cord Injuries surgery, Spinal Fusion methods
- Abstract
A prospective study was performed to evaluate the impact of surgical decompression (SD) and instrumented fusion within 8 h versus 8-24 h after injury on neurological recovery after cervical traumatic spinal cord injury (tSCI) in patients operated on in the UMC Ljubljana, Slovenia. Only patients with the American Spinal Injury Association (ASIA) Impairment Scale (AIS) grades of A through C and with MRI-confirmed spinal cord compression were enrolled. The primary outcome was the change in AIS grade at the 6-month follow-up. Of the 48 enrolled patients, 22 patients who underwent surgery within 8 h (group 8 h) and 20 patients who underwent surgery between 8 and 24 h (Group 8-24 h) after injury concluded the study. At admission, there was no statistically significant difference in AIS grade between the study groups. At the 6-month follow-up, an improvement of at least two AIS grades was found in 45.5% of patients in group 8 h and in 10% of patients in group 8-24 h (p=0.017). The median improvement in the ASIA motor score was 38.5 (10.0-61.0) motor points in group 8 h and 15.0 (8.8-34.0) motor points in group 8-24 h (p=0.0468). In a multivariate analysis, adjusted for the preoperative AIS grade and the degree of spinal canal compromise, the odds of an at least two-grade AIS improvement were at least 106% higher for patients in group 8 h than for patients in group 8-24 h (odds ratio=11.08, p=0.004). No statistically significant difference was found in the rate of perioperative complications, pneumonia, and the number of ventilator-dependent days or the mortality between the groups. Our results suggest that the patients with tSCI who undergo SD within 8 h after injury have superior neurological outcomes than patients who undergo SD 8-24 h after injury, without any increase in the rate of adverse effects.
- Published
- 2015
- Full Text
- View/download PDF
13. Seeds in Chernobyl: the database on proteome response on radioactive environment.
- Author
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Klubicová K, Vesel M, Rashydov NM, and Hajduch M
- Abstract
Two serious nuclear accidents during the last quarter century (Chernobyl, 1986 and Fukushima, 2011) contaminated large agricultural areas with radioactivity. The database "Seeds in Chernobyl" (http://www.chernobylproteomics.sav.sk) contains the information about the abundances of hundreds of proteins from on-going investigation of mature and developing seed harvested from plants grown in radioactive Chernobyl area. This database provides a useful source of information concerning the response of the seed proteome to permanently increased level of ionizing radiation in a user-friendly format.
- Published
- 2012
- Full Text
- View/download PDF
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