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281 results on '"Vervoort, Stephin J."'

1. Epigenetic modulators of B cell fate identified through coupled phenotype-transcriptome analysis

Author

Kong, Isabella Y., Trezise, Stephanie, Light, Amanda, Todorovski, Izabela, Arnau, Gisela Mir, Gadipally, Sreeja, Yoannidis, David, Simpson, Kaylene J., Dong, Xueyi, Whitehead, Lachlan, Tempany, Jessica C., Farchione, Anthony J., Sheikh, Amania A., Groom, Joanna R., Rogers, Kelly L., Herold, Marco J., Bryant, Vanessa L., Ritchie, Matthew E., Willis, Simon N., Johnstone, Ricky W., Hodgkin, Philip D., Nutt, Stephen L., Vervoort, Stephin J., and Hawkins, Edwin D.

Published
2022
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2. CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity

Author

House, Imran G., Derrick, Emily B., Sek, Kevin, Chen, Amanda X.Y., Li, Jasmine, Lai, Junyun, Todd, Kirsten L., Munoz, Isabelle, Michie, Jessica, Chan, Cheok Weng, Huang, Yu-Kuan, Chan, Jack D., Petley, Emma V., Tong, Junming, Nguyen, DatMinh, Engel, Sven, Savas, Peter, Hogg, Simon J., Vervoort, Stephin J., Kearney, Conor J., Burr, Marian L., Lam, Enid Y.N., Gilan, Omer, Bedoui, Sammy, Johnstone, Ricky W., Dawson, Mark A., Loi, Sherene, Darcy, Phillip K., and Beavis, Paul A.

Published
2023
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4. Mapping the IMiD‐dependent cereblon interactome using BioID‐proximity labelling.

Author

Costacurta, Matteo, Sandow, Jarrod J., Maher, Belinda, Susanto, Olivia, Vervoort, Stephin J., Devlin, Jennifer R., Garama, Daniel, Condina, Mark R., Steele, Joel R., Kahrood, Hossein V., Gough, Daniel, Johnstone, Ricky W., and Shortt, Jake

Abstract

Immunomodulatory imide drugs (IMiDs) are central components of therapy for multiple myeloma (MM). IMiDs bind cereblon (CRBN), an adaptor for the CUL4‐DDB1‐RBX1 E3 ligase to change its substrate specificity and induce degradation of 'neosubstrate' transcription factors that are essential to MM cells. Mechanistic studies to date have largely focussed on mediators of therapeutic activity and insight into clinical IMiD toxicities is less developed. We adopted BioID2‐dependent proximity labelling (BioID2‐CRBN) to characterise the CRBN interactome in the presence and absence of various IMiDs and the proteasome inhibitor, bortezomib. We aimed to leverage this technology to further map CRBN interactions beyond what has been achieved by conventional proteomic techniques. In support of this approach, analysis of cells expressing BioID2‐CRBN following IMiD treatment displayed biotinylation of known CRBN interactors and neosubstrates. We observed that bortezomib alone significantly modifies the CRBN interactome. Proximity labelling also suggested that IMiDs augment the interaction between CRBN and proteins that are not degraded, thus designating 'neointeractors' distinct from previously disclosed 'neosubstrates'. Here we identify Non‐Muscle Myosin Heavy Chain IIA (MYH9) as a putative CRBN neointeractor that may contribute to the haematological toxicity of IMiDs. These studies provide proof of concept for proximity labelling technologies in the mechanistic profiling of IMiDs and related E3‐ligase‐modulating drugs. [ABSTRACT FROM AUTHOR]

Published
2024
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6. PRMT1 acts as a suppressor of MHC-I and anti-tumor immunity

Author

Djajawi, Tirta M., primary, Pijpers, Lizzy, additional, Srivaths, Akash, additional, Chisanga, David, additional, Chan, Kok Fei, additional, Hogg, Simon J., additional, Neil, Liam, additional, Rivera, Sarahi Mendoza, additional, Bartonicek, Nenad, additional, Ellis, Sarah L., additional, Lim Kam Sian, Terry C.C., additional, Faridi, Pouya, additional, Liao, Yang, additional, Pal, Bhupinder, additional, Behren, Andreas, additional, Shi, Wei, additional, Vervoort, Stephin J., additional, Johnstone, Ricky W., additional, and Kearney, Conor J., additional

Published
2024
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8. CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity

Author

House, Imran G., primary, Derrick, Emily B., additional, Sek, Kevin, additional, Chen, Amanda X.Y., additional, Li, Jasmine, additional, Lai, Junyun, additional, Todd, Kirsten L., additional, Munoz, Isabelle, additional, Michie, Jessica, additional, Chan, Cheok Weng, additional, Huang, Yu-Kuan, additional, Chan, Jack D., additional, Petley, Emma V., additional, Tong, Junming, additional, Nguyen, DatMinh, additional, Engel, Sven, additional, Savas, Peter, additional, Hogg, Simon J., additional, Vervoort, Stephin J., additional, Kearney, Conor J., additional, Burr, Marian L., additional, Lam, Enid Y.N., additional, Gilan, Omer, additional, Bedoui, Sammy, additional, Johnstone, Ricky W., additional, Dawson, Mark A., additional, Loi, Sherene, additional, Darcy, Phillip K., additional, and Beavis, Paul A., additional

Published
2024
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9. Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance

Author

Wagle, Mayura V., Vervoort, Stephin J., Kelly, Madison J., Van Der Byl, Willem, Peters, Timothy J., Martin, Ben P., Martelotto, Luciano G., Nüssing, Simone, Ramsbottom, Kelly M., Torpy, James R., Knight, Deborah, Reading, Sinead, Thia, Kevin, Miosge, Lisa A., Howard, Debbie R., Gloury, Renee, Gabriel, Sarah S., Utzschneider, Daniel T., Oliaro, Jane, Powell, Jonathan D., Luciani, Fabio, Trapani, Joseph A., Johnstone, Ricky W., Kallies, Axel, Goodnow, Christopher C., and Parish, Ian A.

Published
2021
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10. Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity

Author

Lai, Junyun, Mardiana, Sherly, House, Imran G., Sek, Kevin, Henderson, Melissa A., Giuffrida, Lauren, Chen, Amanda X. Y., Todd, Kirsten L., Petley, Emma V., Chan, Jack D., Carrington, Emma M., Lew, Andrew M., Solomon, Benjamin J., Trapani, Joseph A., Kedzierska, Katherine, Evrard, Maximilien, Vervoort, Stephin J., Waithman, Jason, Darcy, Phillip K., and Beavis, Paul A.

Published
2020
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11. Complexity and Diversity of the Mammalian Sialome Revealed by Nidovirus Virolectins.

Author

Langereis, Martijn A, Bakkers, Mark JG, Deng, Lingquan, Padler-Karavani, Vered, Vervoort, Stephin J, Hulswit, Ruben JG, van Vliet, Arno LW, Gerwig, Gerrit J, de Poot, Stefanie AH, Boot, Willemijn, van Ederen, Anne Marie, Heesters, Balthasar A, van der Loos, Chris M, van Kuppeveld, Frank JM, Yu, Hai, Huizinga, Eric G, Chen, Xi, Varki, Ajit, Kamerling, Johannis P, and de Groot, Raoul J

Subjects
Animals, Mammals, Humans, Nidovirales, Sialic Acids, N-Acetylneuraminic Acid, Acetylesterase, Lipids, Proteins, Viral Fusion Proteins, Hemagglutinins, Viral, Species Specificity, Gene Expression Regulation, Acetylation, Genome, Hemagglutinins, Viral, Biochemistry and Cell Biology, Medical Physiology
Abstract

Sialic acids (Sias), 9-carbon-backbone sugars, are among the most complex and versatile molecules of life. As terminal residues of glycans on proteins and lipids, Sias are key elements of glycotopes of both cellular and microbial lectins and thus act as important molecular tags in cell recognition and signaling events. Their functions in such interactions can be regulated by post-synthetic modifications, the most common of which is differential Sia-O-acetylation (O-Ac-Sias). The biology of O-Ac-Sias remains mostly unexplored, largely because of limitations associated with their specific in situ detection. Here, we show that dual-function hemagglutinin-esterase envelope proteins of nidoviruses distinguish between a variety of closely related O-Ac-Sias. By using soluble forms of hemagglutinin-esterases as lectins and sialate-O-acetylesterases, we demonstrate differential expression of distinct O-Ac-sialoglycan populations in an organ-, tissue- and cell-specific fashion. Our findings indicate that programmed Sia-O-acetylation/de-O-acetylation may be critical to key aspects of cell development, homeostasis, and/or function.

Published
2015

14. Tumor immune evasion: insights from CRISPR screens and future directions.

Author

Djajawi, Tirta Mario, Wichmann, Johannes, Vervoort, Stephin J., and Kearney, Conor J.

Subjects
CRISPRS, MEDICAL screening, IMMUNE checkpoint proteins, CELLULAR therapy, IMMUNE system
Abstract

Despite the clinical success of cancer immunotherapies including immune checkpoint blockade and adoptive cellular therapies across a variety of cancer types, many patients do not respond or ultimately relapse; however, the molecular underpinnings of this are not fully understood. Thus, a system‐level understating of the routes to tumor immune evasion is required to inform the design of the next generation of immunotherapy approaches. CRISPR screening approaches have proved extremely powerful in identifying genes that promote tumor immune evasion or sensitize tumor cells to destruction by the immune system. These large‐scale efforts have brought to light decades worth of fundamental immunology and have uncovered the key immune‐evasion pathways subverted in cancers in an acquired manner in patients receiving immune‐modulatory therapies. The comprehensive discovery of the main pathways involved in immune evasion has spurred the development and application of novel immune therapies to target this process. Although successful, conventional CRISPR screening approaches are hampered by a number of limitations, which obfuscate a complete understanding of the precise molecular regulation of immune evasion in cancer. Here, we provide a perspective on screening approaches to interrogate tumor‐lymphocyte interactions and their limitations, and discuss further development of technologies to improve such approaches and discovery capability. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Supplementary Table from Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML

Author

Salmon, Jessica M., primary, Todorovski, Izabela, primary, Stanley, Kym L., primary, Bruedigam, Claudia, primary, Kearney, Conor J., primary, Martelotto, Luciano G., primary, Rossello, Fernando, primary, Semple, Timothy, primary, Arnau, Gisela Mir, primary, Zethoven, Magnus, primary, Bots, Michael, primary, Bjelosevic, Stefan, primary, Cluse, Leonie A., primary, Fraser, Peter J., primary, Litalien, Veronique, primary, Vidacs, Eva, primary, McArthur, Kate, primary, Matthews, Antony Y., primary, Gressier, Elise, primary, de Weerd, Nicole A., primary, Lichte, Jens, primary, Kelly, Madison J., primary, Hogg, Simon J., primary, Hertzog, Paul J., primary, Kats, Lev M., primary, Vervoort, Stephin J., primary, De Carvalho, Daniel D., primary, Scheu, Stefanie, primary, Bedoui, Sammy, primary, Kile, Benjamin T., primary, Lane, Steven W., primary, Perkins, Andrew C., primary, Wei, Andrew H., primary, Dominguez, Pilar M., primary, and Johnstone, Ricky W., primary

Published
2023
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18. Supplementary Table S1 from BET Inhibition Enhances TNF-Mediated Antitumor Immunity

Author

Wellinger, Lisa C., primary, Hogg, Simon J., primary, Newman, Dane M., primary, Friess, Thomas, primary, Geiss, Daniela, primary, Michie, Jessica, primary, Ramsbottom, Kelly M., primary, Bacac, Marina, primary, Fauti, Tanja, primary, Marbach, Daniel, primary, Jarassier, Laura, primary, Thienger, Phillip, primary, Paehler, Axel, primary, Cluse, Leonie A., primary, Kearney, Conor J., primary, Vervoort, Stephin J., primary, Trapani, Joseph A., primary, Oliaro, Jane, primary, Shortt, Jake, primary, Ruefli-Brasse, Astrid, primary, Rohle, Daniel, primary, and Johnstone, Ricky W., primary

Published
2023
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19. Video 1 from BET Inhibition Enhances TNF-Mediated Antitumor Immunity

Author

Wellinger, Lisa C., primary, Hogg, Simon J., primary, Newman, Dane M., primary, Friess, Thomas, primary, Geiss, Daniela, primary, Michie, Jessica, primary, Ramsbottom, Kelly M., primary, Bacac, Marina, primary, Fauti, Tanja, primary, Marbach, Daniel, primary, Jarassier, Laura, primary, Thienger, Phillip, primary, Paehler, Axel, primary, Cluse, Leonie A., primary, Kearney, Conor J., primary, Vervoort, Stephin J., primary, Trapani, Joseph A., primary, Oliaro, Jane, primary, Shortt, Jake, primary, Ruefli-Brasse, Astrid, primary, Rohle, Daniel, primary, and Johnstone, Ricky W., primary

Published
2023
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20. Data from Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML

Author

Salmon, Jessica M., primary, Todorovski, Izabela, primary, Stanley, Kym L., primary, Bruedigam, Claudia, primary, Kearney, Conor J., primary, Martelotto, Luciano G., primary, Rossello, Fernando, primary, Semple, Timothy, primary, Arnau, Gisela Mir, primary, Zethoven, Magnus, primary, Bots, Michael, primary, Bjelosevic, Stefan, primary, Cluse, Leonie A., primary, Fraser, Peter J., primary, Litalien, Veronique, primary, Vidacs, Eva, primary, McArthur, Kate, primary, Matthews, Antony Y., primary, Gressier, Elise, primary, de Weerd, Nicole A., primary, Lichte, Jens, primary, Kelly, Madison J., primary, Hogg, Simon J., primary, Hertzog, Paul J., primary, Kats, Lev M., primary, Vervoort, Stephin J., primary, De Carvalho, Daniel D., primary, Scheu, Stefanie, primary, Bedoui, Sammy, primary, Kile, Benjamin T., primary, Lane, Steven W., primary, Perkins, Andrew C., primary, Wei, Andrew H., primary, Dominguez, Pilar M., primary, and Johnstone, Ricky W., primary

Published
2023
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21. Data from BET Inhibition Enhances TNF-Mediated Antitumor Immunity

Author

Wellinger, Lisa C., primary, Hogg, Simon J., primary, Newman, Dane M., primary, Friess, Thomas, primary, Geiss, Daniela, primary, Michie, Jessica, primary, Ramsbottom, Kelly M., primary, Bacac, Marina, primary, Fauti, Tanja, primary, Marbach, Daniel, primary, Jarassier, Laura, primary, Thienger, Phillip, primary, Paehler, Axel, primary, Cluse, Leonie A., primary, Kearney, Conor J., primary, Vervoort, Stephin J., primary, Trapani, Joseph A., primary, Oliaro, Jane, primary, Shortt, Jake, primary, Ruefli-Brasse, Astrid, primary, Rohle, Daniel, primary, and Johnstone, Ricky W., primary

Published
2023
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22. Video 3 from BET Inhibition Enhances TNF-Mediated Antitumor Immunity

Author

Wellinger, Lisa C., primary, Hogg, Simon J., primary, Newman, Dane M., primary, Friess, Thomas, primary, Geiss, Daniela, primary, Michie, Jessica, primary, Ramsbottom, Kelly M., primary, Bacac, Marina, primary, Fauti, Tanja, primary, Marbach, Daniel, primary, Jarassier, Laura, primary, Thienger, Phillip, primary, Paehler, Axel, primary, Cluse, Leonie A., primary, Kearney, Conor J., primary, Vervoort, Stephin J., primary, Trapani, Joseph A., primary, Oliaro, Jane, primary, Shortt, Jake, primary, Ruefli-Brasse, Astrid, primary, Rohle, Daniel, primary, and Johnstone, Ricky W., primary

Published
2023
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23. Supplementary Figure from Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML

Author

Salmon, Jessica M., primary, Todorovski, Izabela, primary, Stanley, Kym L., primary, Bruedigam, Claudia, primary, Kearney, Conor J., primary, Martelotto, Luciano G., primary, Rossello, Fernando, primary, Semple, Timothy, primary, Arnau, Gisela Mir, primary, Zethoven, Magnus, primary, Bots, Michael, primary, Bjelosevic, Stefan, primary, Cluse, Leonie A., primary, Fraser, Peter J., primary, Litalien, Veronique, primary, Vidacs, Eva, primary, McArthur, Kate, primary, Matthews, Antony Y., primary, Gressier, Elise, primary, de Weerd, Nicole A., primary, Lichte, Jens, primary, Kelly, Madison J., primary, Hogg, Simon J., primary, Hertzog, Paul J., primary, Kats, Lev M., primary, Vervoort, Stephin J., primary, De Carvalho, Daniel D., primary, Scheu, Stefanie, primary, Bedoui, Sammy, primary, Kile, Benjamin T., primary, Lane, Steven W., primary, Perkins, Andrew C., primary, Wei, Andrew H., primary, Dominguez, Pilar M., primary, and Johnstone, Ricky W., primary

Published
2023
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24. Video 2 from BET Inhibition Enhances TNF-Mediated Antitumor Immunity

Author

Wellinger, Lisa C., primary, Hogg, Simon J., primary, Newman, Dane M., primary, Friess, Thomas, primary, Geiss, Daniela, primary, Michie, Jessica, primary, Ramsbottom, Kelly M., primary, Bacac, Marina, primary, Fauti, Tanja, primary, Marbach, Daniel, primary, Jarassier, Laura, primary, Thienger, Phillip, primary, Paehler, Axel, primary, Cluse, Leonie A., primary, Kearney, Conor J., primary, Vervoort, Stephin J., primary, Trapani, Joseph A., primary, Oliaro, Jane, primary, Shortt, Jake, primary, Ruefli-Brasse, Astrid, primary, Rohle, Daniel, primary, and Johnstone, Ricky W., primary

Published
2023
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25. Video 4 from BET Inhibition Enhances TNF-Mediated Antitumor Immunity

Author

Wellinger, Lisa C., primary, Hogg, Simon J., primary, Newman, Dane M., primary, Friess, Thomas, primary, Geiss, Daniela, primary, Michie, Jessica, primary, Ramsbottom, Kelly M., primary, Bacac, Marina, primary, Fauti, Tanja, primary, Marbach, Daniel, primary, Jarassier, Laura, primary, Thienger, Phillip, primary, Paehler, Axel, primary, Cluse, Leonie A., primary, Kearney, Conor J., primary, Vervoort, Stephin J., primary, Trapani, Joseph A., primary, Oliaro, Jane, primary, Shortt, Jake, primary, Ruefli-Brasse, Astrid, primary, Rohle, Daniel, primary, and Johnstone, Ricky W., primary

Published
2023
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26. Supplementary Video Legends and Figures from BET Inhibition Enhances TNF-Mediated Antitumor Immunity

Author

Wellinger, Lisa C., primary, Hogg, Simon J., primary, Newman, Dane M., primary, Friess, Thomas, primary, Geiss, Daniela, primary, Michie, Jessica, primary, Ramsbottom, Kelly M., primary, Bacac, Marina, primary, Fauti, Tanja, primary, Marbach, Daniel, primary, Jarassier, Laura, primary, Thienger, Phillip, primary, Paehler, Axel, primary, Cluse, Leonie A., primary, Kearney, Conor J., primary, Vervoort, Stephin J., primary, Trapani, Joseph A., primary, Oliaro, Jane, primary, Shortt, Jake, primary, Ruefli-Brasse, Astrid, primary, Rohle, Daniel, primary, and Johnstone, Ricky W., primary

Published
2023
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27. Movie 1 from Antagonism of IAPs Enhances CAR T-cell Efficacy

Author

Michie, Jessica, primary, Beavis, Paul A., primary, Freeman, Andrew J., primary, Vervoort, Stephin J., primary, Ramsbottom, Kelly M., primary, Narasimhan, Vignesh, primary, Lelliott, Emily J., primary, Lalaoui, Najoua, primary, Ramsay, Robert G., primary, Johnstone, Ricky W., primary, Silke, John, primary, Darcy, Phillip K., primary, Voskoboinik, Ilia, primary, Kearney, Conor J., primary, and Oliaro, Jane, primary

Published
2023
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28. Suppllementary Methods and Supplementary Figures 1-5 from BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members

Author

Hogg, Simon J., primary, Newbold, Andrea, primary, Vervoort, Stephin J., primary, Cluse, Leonie A., primary, Martin, Benjamin P., primary, Gregory, Gareth P., primary, Lefebure, Marcus, primary, Vidacs, Eva, primary, Tothill, Richard W., primary, Bradner, James E., primary, Shortt, Jake, primary, and Johnstone, Ricky W., primary

Published
2023
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29. Data from BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members

Author

Hogg, Simon J., primary, Newbold, Andrea, primary, Vervoort, Stephin J., primary, Cluse, Leonie A., primary, Martin, Benjamin P., primary, Gregory, Gareth P., primary, Lefebure, Marcus, primary, Vidacs, Eva, primary, Tothill, Richard W., primary, Bradner, James E., primary, Shortt, Jake, primary, and Johnstone, Ricky W., primary

Published
2023
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30. Data from CDK4/6 Inhibition Promotes Antitumor Immunity through the Induction of T-cell Memory

Author

Lelliott, Emily J., primary, Kong, Isabella Y., primary, Zethoven, Magnus, primary, Ramsbottom, Kelly M., primary, Martelotto, Luciano G., primary, Meyran, Deborah, primary, Zhu, Joe Jiang, primary, Costacurta, Matteo, primary, Kirby, Laura, primary, Sandow, Jarrod J., primary, Lim, Lydia, primary, Dominguez, Pilar M., primary, Todorovski, Izabela, primary, Haynes, Nicole M., primary, Beavis, Paul A., primary, Neeson, Paul J., primary, Hawkins, Edwin D., primary, McArthur, Grant A., primary, Parish, Ian A., primary, Johnstone, Ricky W., primary, Oliaro, Jane, primary, Sheppard, Karen E., primary, Kearney, Conor J., primary, and Vervoort, Stephin J., primary

Published
2023
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31. Data from Antagonism of IAPs Enhances CAR T-cell Efficacy

Author

Michie, Jessica, primary, Beavis, Paul A., primary, Freeman, Andrew J., primary, Vervoort, Stephin J., primary, Ramsbottom, Kelly M., primary, Narasimhan, Vignesh, primary, Lelliott, Emily J., primary, Lalaoui, Najoua, primary, Ramsay, Robert G., primary, Johnstone, Ricky W., primary, Silke, John, primary, Darcy, Phillip K., primary, Voskoboinik, Ilia, primary, Kearney, Conor J., primary, and Oliaro, Jane, primary

Published
2023
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32. Supplementary Figures 1 and 2 from Antagonism of IAPs Enhances CAR T-cell Efficacy

Author

Michie, Jessica, primary, Beavis, Paul A., primary, Freeman, Andrew J., primary, Vervoort, Stephin J., primary, Ramsbottom, Kelly M., primary, Narasimhan, Vignesh, primary, Lelliott, Emily J., primary, Lalaoui, Najoua, primary, Ramsay, Robert G., primary, Johnstone, Ricky W., primary, Silke, John, primary, Darcy, Phillip K., primary, Voskoboinik, Ilia, primary, Kearney, Conor J., primary, and Oliaro, Jane, primary

Published
2023
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33. TableS1.xlsx from CDK4/6 Inhibition Promotes Antitumor Immunity through the Induction of T-cell Memory

Author

Lelliott, Emily J., primary, Kong, Isabella Y., primary, Zethoven, Magnus, primary, Ramsbottom, Kelly M., primary, Martelotto, Luciano G., primary, Meyran, Deborah, primary, Zhu, Joe Jiang, primary, Costacurta, Matteo, primary, Kirby, Laura, primary, Sandow, Jarrod J., primary, Lim, Lydia, primary, Dominguez, Pilar M., primary, Todorovski, Izabela, primary, Haynes, Nicole M., primary, Beavis, Paul A., primary, Neeson, Paul J., primary, Hawkins, Edwin D., primary, McArthur, Grant A., primary, Parish, Ian A., primary, Johnstone, Ricky W., primary, Oliaro, Jane, primary, Sheppard, Karen E., primary, Kearney, Conor J., primary, and Vervoort, Stephin J., primary

Published
2023
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34. Supplementary Data Legends from Antagonism of IAPs Enhances CAR T-cell Efficacy

Author

Michie, Jessica, primary, Beavis, Paul A., primary, Freeman, Andrew J., primary, Vervoort, Stephin J., primary, Ramsbottom, Kelly M., primary, Narasimhan, Vignesh, primary, Lelliott, Emily J., primary, Lalaoui, Najoua, primary, Ramsay, Robert G., primary, Johnstone, Ricky W., primary, Silke, John, primary, Darcy, Phillip K., primary, Voskoboinik, Ilia, primary, Kearney, Conor J., primary, and Oliaro, Jane, primary

Published
2023
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35. Movie 2 from Antagonism of IAPs Enhances CAR T-cell Efficacy

Author

Michie, Jessica, primary, Beavis, Paul A., primary, Freeman, Andrew J., primary, Vervoort, Stephin J., primary, Ramsbottom, Kelly M., primary, Narasimhan, Vignesh, primary, Lelliott, Emily J., primary, Lalaoui, Najoua, primary, Ramsay, Robert G., primary, Johnstone, Ricky W., primary, Silke, John, primary, Darcy, Phillip K., primary, Voskoboinik, Ilia, primary, Kearney, Conor J., primary, and Oliaro, Jane, primary

Published
2023
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36. Supplementary Figures from CDK4/6 Inhibition Promotes Antitumor Immunity through the Induction of T-cell Memory

Author

Lelliott, Emily J., primary, Kong, Isabella Y., primary, Zethoven, Magnus, primary, Ramsbottom, Kelly M., primary, Martelotto, Luciano G., primary, Meyran, Deborah, primary, Zhu, Joe Jiang, primary, Costacurta, Matteo, primary, Kirby, Laura, primary, Sandow, Jarrod J., primary, Lim, Lydia, primary, Dominguez, Pilar M., primary, Todorovski, Izabela, primary, Haynes, Nicole M., primary, Beavis, Paul A., primary, Neeson, Paul J., primary, Hawkins, Edwin D., primary, McArthur, Grant A., primary, Parish, Ian A., primary, Johnstone, Ricky W., primary, Oliaro, Jane, primary, Sheppard, Karen E., primary, Kearney, Conor J., primary, and Vervoort, Stephin J., primary

Published
2023
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37. Supplementary Information from HDAC Inhibitor Panobinostat Engages Host Innate Immune Defenses to Promote the Tumoricidal Effects of Trastuzumab in HER2+ Tumors

Author

Medon, Mikolaj, primary, Vidacs, Eva, primary, Vervoort, Stephin J, primary, Li, Jason, primary, Jenkins, Misty R., primary, Ramsbottom, Kelly M., primary, Trapani, Joseph A., primary, Smyth, Mark J., primary, Darcy, Phillip K., primary, Atadja, Peter W., primary, Henderson, Michael A., primary, Johnstone, Ricky W., primary, and Haynes, Nicole M., primary

Published
2023
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38. Epigenetic changes in inflammatory arthritis monocytes contribute to disease and can be targeted by JAK inhibition

Author

CMM Groep Coffer, CDL Cluster Onderzoek en Onderwijs, CTI Van Loosdregt, CMM Sectie Stem Cells, Onderzoek, Cancer, Infection & Immunity, Regenerative Medicine and Stem Cells, CDL Onderzoek Pasterkamp, Experimentele Afd. Cardiologie 1, Child Health, Circulatory Health, Immuno/reuma onderzoek 1 (Vastert), Immunologie/Reumatologie, CTI Van Wijk, CTI Research, Immuno/reuma onderzoek 3 (Loosdregt), Peeters, Janneke G C, Boltjes, Arjan, Scholman, Rianne C, Vervoort, Stephin J, Coffer, Paul J, Mokry, Michal, Vastert, Sebastiaan J, van Wijk, Femke, van Loosdregt, Jorg, CMM Groep Coffer, CDL Cluster Onderzoek en Onderwijs, CTI Van Loosdregt, CMM Sectie Stem Cells, Onderzoek, Cancer, Infection & Immunity, Regenerative Medicine and Stem Cells, CDL Onderzoek Pasterkamp, Experimentele Afd. Cardiologie 1, Child Health, Circulatory Health, Immuno/reuma onderzoek 1 (Vastert), Immunologie/Reumatologie, CTI Van Wijk, CTI Research, Immuno/reuma onderzoek 3 (Loosdregt), Peeters, Janneke G C, Boltjes, Arjan, Scholman, Rianne C, Vervoort, Stephin J, Coffer, Paul J, Mokry, Michal, Vastert, Sebastiaan J, van Wijk, Femke, and van Loosdregt, Jorg

Published
2023

39. Intracellular zinc protects tumours from T cell-mediated cytotoxicity

Author

Lelliott, Emily J., Naddaf, Jonathan, Ganio, Katherine, Michie, Jessica, Wang, Shelly, Liu, Lin, Silke, Natasha, Ahn, Antonio, Ramsbottom, Kelly M., Brennan, Amelia J., Freeman, Andrew J., Goel, Shom, Vervoort, Stephin J., Kearney, Conor J., Beavis, Paul A., McDevitt, Christopher A., Silke, John, and Oliaro, Jane

Abstract

Tumour immune evasion presents a significant challenge to the effectiveness of cancer immunotherapies. Recent advances in high-throughput screening techniques have uncovered that loss of antigen presentation and cytokine signalling pathways are central mechanisms by which tumours evade T cell immunity. To uncover additional vulnerabilities in tumour cells beyond the well-recognized antigen presentation pathway, we conducted a genome-wide CRISPR/Cas9 screen to identify genes that mediate resistance to chimeric-antigen receptor (CAR)-T cells, which function independently of classical antigen presentation. Our study revealed that loss of core-binding factor subunit beta (CBFβ) enhances tumour cell resistance to T cell killing, mediated through T cell-derived TNF. Mechanistically, RNA-sequencing and elemental analyses revealed that deletion of CBFβ disrupts numerous pathways including those involved in zinc homoeostasis. Moreover, we demonstrated that modulation of cellular zinc, achieved by supplementation or chelation, significantly altered tumour cell susceptibility to TNF by regulating the levels of inhibitor of apoptosis proteins. Consistent with this, treatment of tumour cells with a membrane-permeable zinc chelator had no impact on tumour cell viability alone, but significantly increased tumour cell lysis by CD8+ T cells in a TNF-dependent but perforin-independent manner. These results underscore the crucial role of intracellular zinc in regulating tumour cell susceptibility to T cell-mediated killing, revealing a novel vulnerability in tumour cells that might be exploited for the development of future cancer immunotherapeutics.

Published
2024
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43. RNA decay defines the response to transcriptional perturbation in leukaemia

Author

Todorovski, Izabela, primary, Feran, Breon, additional, Fan, Zheng, additional, Gadipally, Sreeja, additional, Yoannidis, David, additional, Kong, Isabella Y, additional, Bjelosevic, Stefan, additional, Zethoven, Magnus, additional, Hawkins, Edwin D, additional, Simpson, Kaylene J, additional, Arnau, Gisela Mir, additional, Papenfuss, Anthony T, additional, Johnstone, Ricky W, additional, and Vervoort, Stephin J, additional

Published
2022
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44. Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML

Author

Salmon, Jessica M., primary, Todorovski, Izabela, additional, Stanley, Kym L., additional, Bruedigam, Claudia, additional, Kearney, Conor J., additional, Martelotto, Luciano G., additional, Rossello, Fernando, additional, Semple, Timothy, additional, Arnau, Gisela Mir, additional, Zethoven, Magnus, additional, Bots, Michael, additional, Bjelosevic, Stefan, additional, Cluse, Leonie A., additional, Fraser, Peter J., additional, Litalien, Veronique, additional, Vidacs, Eva, additional, McArthur, Kate, additional, Matthews, Antony Y., additional, Gressier, Elise, additional, de Weerd, Nicole A., additional, Lichte, Jens, additional, Kelly, Madison J., additional, Hogg, Simon J., additional, Hertzog, Paul J., additional, Kats, Lev M., additional, Vervoort, Stephin J., additional, De Carvalho, Daniel D., additional, Scheu, Stefanie, additional, Bedoui, Sammy, additional, Kile, Benjamin T., additional, Lane, Steven W., additional, Perkins, Andrew C., additional, Wei, Andrew H., additional, Dominguez, Pilar M., additional, and Johnstone, Ricky W., additional

Published
2022
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45. BET Inhibition Enhances TNF-Mediated Antitumor Immunity

Author

Wellinger, Lisa C., primary, Hogg, Simon J., additional, Newman, Dane M., additional, Friess, Thomas, additional, Geiss, Daniela, additional, Michie, Jessica, additional, Ramsbottom, Kelly M., additional, Bacac, Marina, additional, Fauti, Tanja, additional, Marbach, Daniel, additional, Jarassier, Laura, additional, Thienger, Phillip, additional, Paehler, Axel, additional, Cluse, Leonie A., additional, Kearney, Conor J., additional, Vervoort, Stephin J., additional, Trapani, Joseph A., additional, Oliaro, Jane, additional, Shortt, Jake, additional, Ruefli-Brasse, Astrid, additional, Rohle, Daniel, additional, and Johnstone, Ricky W., additional

Published
2022
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46. Targeting transcription cycles in cancer

Author

Vervoort, Stephin J., primary, Devlin, Jennifer R., additional, Kwiatkowski, Nicholas, additional, Teng, Mingxing, additional, Gray, Nathanael S., additional, and Johnstone, Ricky W., additional

Published
2021
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47. The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer

Author

Vervoort, Stephin J., primary, Welsh, Sarah A., additional, Devlin, Jennifer R., additional, Barbieri, Elisa, additional, Knight, Deborah A., additional, Offley, Sarah, additional, Bjelosevic, Stefan, additional, Costacurta, Matteo, additional, Todorovski, Izabela, additional, Kearney, Conor J., additional, Sandow, Jarrod J., additional, Fan, Zheng, additional, Blyth, Benjamin, additional, McLeod, Victoria, additional, Vissers, Joseph H.A., additional, Pavic, Karolina, additional, Martin, Ben P., additional, Gregory, Gareth, additional, Demosthenous, Elena, additional, Zethoven, Magnus, additional, Kong, Isabella Y., additional, Hawkins, Edwin D., additional, Hogg, Simon J., additional, Kelly, Madison J., additional, Newbold, Andrea, additional, Simpson, Kaylene J., additional, Kauko, Otto, additional, Harvey, Kieran F., additional, Ohlmeyer, Michael, additional, Westermarck, Jukka, additional, Gray, Nathanael, additional, Gardini, Alessandro, additional, and Johnstone, Ricky W., additional

Published
2021
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48. Antigen-driven EGR2 expression is required for exhausted CD8 + T cell stability and maintenance

Author

Wagle, Mayura, Vervoort, Stephin J., Kelly, Madison J, Van Der Byl, Willem, Peters, Timothy J., Martin, Benjamin, Martelotto, Luciano G., Nüssing, Simone, Ramsbottom, Kelly M., Torpy, James, Knight, Deborah, Reading, Sinead, Thia, Kevin Y.T., Miosge, Lisa, Howard, Debbie, Goodnow, Christopher, Parish, Ian, Wagle, Mayura, Vervoort, Stephin J., Kelly, Madison J, Van Der Byl, Willem, Peters, Timothy J., Martin, Benjamin, Martelotto, Luciano G., Nüssing, Simone, Ramsbottom, Kelly M., Torpy, James, Knight, Deborah, Reading, Sinead, Thia, Kevin Y.T., Miosge, Lisa, Howard, Debbie, Goodnow, Christopher, and Parish, Ian

Abstract

Chronic stimulation of CD8 T cells triggers exhaustion, a distinct differentiation state with diminished effector function. Exhausted cells exist in multiple differentiation states, from stem-like progenitors that are the key mediators of the response to checkpoint blockade, through to terminally exhausted cells. Due to its clinical relevance, there is substantial interest in defining the pathways that control differentiation and maintenance of these subsets. Here, we show that chronic antigen induces the anergy-associated transcription factor EGR2 selectively within progenitor exhausted cells in both chronic LCMV and tumours. EGR2 enables terminal exhaustion and stabilizes the exhausted transcriptional state by both direct EGR2-dependent control of key exhaustion-associated genes, and indirect maintenance of the exhausted epigenetic state. We show that EGR2 is a regulator of exhaustion that epigenetically and transcriptionally maintains the differentiation competency of progenitor exhausted cells. +

Published
2021

49. CDK4/6 Inhibition Promotes Antitumor Immunity through the Induction of T-cell Memory

Author

Lelliott, Emily J., primary, Kong, Isabella Y., additional, Zethoven, Magnus, additional, Ramsbottom, Kelly M., additional, Martelotto, Luciano G., additional, Meyran, Deborah, additional, Zhu, Joe Jiang, additional, Costacurta, Matteo, additional, Kirby, Laura, additional, Sandow, Jarrod J., additional, Lim, Lydia, additional, Dominguez, Pilar M., additional, Todorovski, Izabela, additional, Haynes, Nicole M., additional, Beavis, Paul A., additional, Neeson, Paul J., additional, Hawkins, Edwin D., additional, McArthur, Grant A., additional, Parish, Ian A., additional, Johnstone, Ricky W., additional, Oliaro, Jane, additional, Sheppard, Karen E., additional, Kearney, Conor J., additional, and Vervoort, Stephin J., additional

Published
2021
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50. Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition

Author

Hogg, Simon J., primary, Motorna, Olga, additional, Cluse, Leonie A., additional, Johanson, Timothy M., additional, Coughlan, Hannah D., additional, Raviram, Ramya, additional, Myers, Robert M., additional, Costacurta, Matteo, additional, Todorovski, Izabela, additional, Pijpers, Lizzy, additional, Bjelosevic, Stefan, additional, Williams, Tobias, additional, Huskins, Shannon N., additional, Kearney, Conor J., additional, Devlin, Jennifer R., additional, Fan, Zheng, additional, Jabbari, Jafar S., additional, Martin, Ben P., additional, Fareh, Mohamed, additional, Kelly, Madison J., additional, Dupéré-Richer, Daphné, additional, Sandow, Jarrod J., additional, Feran, Breon, additional, Knight, Deborah, additional, Khong, Tiffany, additional, Spencer, Andrew, additional, Harrison, Simon J., additional, Gregory, Gareth, additional, Wickramasinghe, Vihandha O., additional, Webb, Andrew I., additional, Taberlay, Phillippa C., additional, Bromberg, Kenneth D., additional, Lai, Albert, additional, Papenfuss, Anthony T., additional, Smyth, Gordon K., additional, Allan, Rhys S., additional, Licht, Jonathan D., additional, Landau, Dan A., additional, Abdel-Wahab, Omar, additional, Shortt, Jake, additional, Vervoort, Stephin J., additional, and Johnstone, Ricky W., additional

Published
2021
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