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204 results on '"Verschuren W.M."'

1. Depressive Symptoms and Plasma Markers of Alzheimer's Disease and Neurodegeneration: A Coordinated Meta-Analysis of 8 Cohort Studies

Author

Twait, Emma L., Kamarioti, Maria, Verberk, Inge M.W., Teunissen, Charlotte E., Nooyens, Astrid C.J., Monique Verschuren, W.M., Visser, Pieter Jelle, Huisman, Martijn, Kok, Almar A.L., Eline Slagboom, P., Beekman, Marian, Vojinovic, Dina, Lakenberg, Nico, Arfan Ikram, M., Schuurmans, Isabel K., Wolters, Frank J., Moonen, Justine E.F., Gerritsen, Lotte, van der Flier, Wiesje M., and Geerlings, Mirjam I.

Published
2024
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2. Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies

Author

O’Keefe, James H., Tintle, Nathan L., Harris, William S., O’Keefe, Evan L., Sala-Vila, Aleix, Attia, John, Garg, G. Manohar, Hure, Alexis, Bork, Christian Sørensen, Schmidt, Erik Berg, Venø, Stine Krogh, Chien, Kuo-Liong, Chen, Yun-Yu (Amelia), Egert, Sarah, Feldreich, Tobias Rudholm, Ärnlöv, Johan, Lind, Lars, Forouhi, Nita G., Geleijnse, Johanna M., Pertiwi, Kamalita, Imamura, Fumiaki, de Mello Laaksonen, Vanessa, Uusitupa, W. Matti, Tuomilehto, Jaakko, Laakso, Markku, Lankinen, Maria Anneli, Laurin, Danielle, Carmichael, Pierre-Hugues, Lindsay, Joan, Leander, Karin, Laguzzi, Federica, Swenson, Brenton R., Longstreth, William T., Manson, JoAnn E., Mora, Samia, Cook, Nancy R., Marklund, Matti, Melo van Lent, Debora, Murphy, Rachel, Gudnason, Vilmundur, Ninomiya, Toshihara, Hirakawa, Yoichiro, Qian, Frank, Sun, Qi, Hu, Frank, Ardisson Korat, Andres V., Risérus, Ulf, Lázaro, Iolanda, Samieri, Cecilia, Le Goff, Mélanie, Helmer, Catherine, Steur, Marinka, Voortman, Trudy, Ikram, M. Kamran, Tanaka, Toshiko, Das, Jayanta K., Ferrucci, Luigi, Bandinelli, Stefania, Tsai, Michael, Guan, Weihua, Garg, Parveen, Verschuren, W.M. Monique, Boer, Jolanda M.A., Biokstra, Anneke, Virtanen, Jyrki, Wagner, Michael, Westra, Jason, Albuisson, Luc, Yamagishi, Kazumasa, Siscovick, David S., Lemaitre, Rozenn N., and Mozaffarian, Dariush

Published
2024
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4. Associations between dietary inflammatory scores and biomarkers of inflammation in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author

Lécuyer, Lucie, Laouali, Nasser, Viallon, Vivian, Artaud, Fanny, Hébert, James R., Shivappa, Nitin, Agudo, Antonio, Tjønneland, Anne, Mellemkjær, Lene, Kaaks, Rudolf, Katzke, Verena A., Schulze, Matthias B., Frenoy, Pauline, Mancini, Francesca Romana, De Magistris, Maria Santucci, Macciotta, Alessandra, Masala, Giovanna, Agnoli, Claudia, Tumino, Rosario, Boer, Jolanda M.A., Verschuren, W.M. Monique, Enget Jensen, Torill M., Olsen, Karina Standahl, Skeie, Guri, Chirlaque, María-Dolores, Petrova, Dafina, Castro-Espin, Carlota, Quirós, J. Ramón, Guevara, Marcela, Amiano, Pilar, Borné, Yan, Sandström, Maria, Nilsson, Lena Maria, Heath, Alicia K., Mayen, Ana-Lucia, Huybrechts, Inge, Weiderpass, Elisabete, Boutron-Ruault, Marie-Christine, Dossus, Laure, Rinaldi, Sabina, and Truong, Thérèse

Published
2023
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7. Self-Rated Health among Older Adults: Longitudinal Analyses Examining Sex Differences across Different Birth Cohorts and Educational Levels.

Author

Schaap, Laura A., Sialino, Lena D., de la Court, Feline, van Oostrom, Sandra H., Picavet, H. Susan J., Verschuren, W.M. Monique, Visser, Marjolein, and Wijnhoven, Hanneke A.H.

Subjects
OLDER people, GENERAL Health Questionnaire, COHORT analysis, EDUCATIONAL attainment, LONGITUDINAL method
Abstract

Introduction: Given the known female disadvantage in physical and mental health, this study aimed to investigate sex differences in self-rated health (SRH) among older adults, considering the longitudinal course by age, birth cohort, and educational level. Methods: Data from birth cohort 1911–1937 with baseline age 55–81 years (n = 3,107) and birth cohort 1938–1947 with baseline age 55–65 years (n = 1,002) from the Longitudinal Aging Study Amsterdam (LASA) were used. Mixed model analyses were used to examine sex differences in SRH (RAND General Health Perception Questionnaire [RAND-GHPQ], range 0–16) over the age course, testing for effect modification by the birth cohort and educational level (low, middle, high). Results: For both sexes, a decline in SRH was seen with increasing age. Over the age course, there was no significant sex difference in SRH within the older (1911–1937) birth cohort (0.13 lower score on SRH for women compared to men, 95% CI: −0.35 to 0.09) and only a small sex difference in the more recent (1938–1947) birth cohort (0.35 lower score on SRH for women compared to men [95% CI: −0.69 to −0.02], p = 0.04). There was no significant cohort difference in the size of the sex difference (p = 0.279). Those with a higher level of education reported a higher SRH, but between educational levels, there was no significant difference in the size of the sex difference in SRH. Discussion: In this study, no relevant sex difference in SRH over the age course was observed among older adults. Future research on SRH trajectories by sex during aging should take health-related, cognitive, psychosocial, and behavioral factors into account. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Genomics Research of Lifetime Depression in the Netherlands: The BIObanks Netherlands Internet Collaboration (BIONIC) Project

Author

Huider, Floris, primary, Milaneschi, Yuri, additional, Hottenga, Jouke-Jan, additional, Bot, Mariska, additional, Rietman, M. Liset, additional, Kok, Almar A.L., additional, Galesloot, Tessel E., additional, ‘t Hart, Leen M., additional, Rutters, Femke, additional, Blom, Marieke T., additional, Rhebergen, Didi, additional, Visser, Marjolein, additional, Brouwer, Ingeborg, additional, Feskens, Edith, additional, Hartman, Catharina A., additional, Oldehinkel, Albertine J., additional, de Geus, Eco J.C., additional, Kiemeney, Lambertus A., additional, Huisman, Martijn, additional, Picavet, H. Susan J., additional, Verschuren, W.M. Monique, additional, van Loo, Hanna M., additional, Penninx, Brenda W.J.H., additional, and Boomsma, Dorret I., additional

Published
2024
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10. Spatial Lifecourse Epidemiology Reporting Standards (ISLE-ReSt) statement

Author

Jia, Peng, Yu, Chao, Remais, Justin V., Stein, Alfred, Liu, Yu, Brownson, Ross C., Lakerveld, Jeroen, Wu, Tong, Yang, Lijian, Smith, Melody, Amer, Sherif, Pearce, Jamie, Kestens, Yan, Kwan, Mei-Po, Lai, Shengjie, Xu, Fei, Chen, Xi, Rundle, Andrew, Xiao, Qian, Xue, Hong, Luo, Miyang, Zhao, Li, Cheng, Guo, Yang, Shujuan, Zhou, Xiaolu, Li, Yan, Panter, Jenna, Kingham, Simon, Jones, Andy, Johnson, Blair T., Shi, Xun, Zhang, Lin, Wang, Limin, Wu, Jianguo, Mavoa, Suzanne, Toivonen, Tuuli, Mwenda, Kevin M., Wang, Youfa, Verschuren, W.M. Monique, Vermeulen, Roel, and James, Peter

Published
2020
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12. Dietary amino acids and risk of stroke subtypes: a prospective analysis of 356,000 participants in seven European countries

Author

Tong, Tammy Y.N., primary, Clarke, Robert, additional, Schmidt, Julie A., additional, Huybrechts, Inge, additional, Noor, Urwah, additional, Forouhi, Nita G., additional, Imamura, Fumiaki, additional, Travis, Ruth C., additional, Weiderpass, Elisabete, additional, Aleksandrova, Krasimira, additional, Dahm, Christina C., additional, van der Schouw, Yvonne T., additional, Overvad, Kim, additional, Kyrø, Cecilie, additional, Tjønneland, Anne, additional, Kaaks, Rudolf, additional, Katzke, Verena, additional, Schiborn, Catarina, additional, Schulze, Matthias B., additional, Mayen-Chacon, Ana-Lucia, additional, Masala, Giovanna, additional, Sieri, Sabina, additional, de Magistris, Maria Santucci, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Boer, Jolanda M.A., additional, Verschuren, W.M. Monique, additional, Brustad, Magritt, additional, Nøst, Therese Haugdahl, additional, Crous-Bou, Marta, additional, Petrova, Dafina, additional, Amiano, Pilar, additional, Huerta, José María, additional, Moreno-Iribas, Conchi, additional, Engström, Gunnar, additional, Melander, Olle, additional, Johansson, Kristina, additional, Lindvall, Kristina, additional, Aglago, Elom K., additional, Heath, Alicia K., additional, Butterworth, Adam S., additional, Danesh, John, additional, and Key, Timothy J., additional

Published
2023
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16. Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality: An Individual-Level Pooled Analysis of 30 Cohort Studies

Author

Marklund, Matti, Wu, Jason H.Y., Imamura, Fumiaki, Del Gobbo, Liana C., Fretts, Amanda, de Goede, Janette, Shi, Peilin, Tintle, Nathan, Wennberg, Maria, Aslibekyan, Stella, Chen, Tzu-An, de Oliveira Otto, Marcia C., Hirakawa, Yoichiro, Eriksen, Helle Højmark, Kröger, Janine, Laguzzi, Federica, Lankinen, Maria, Murphy, Rachel A., Prem, Kiesha, Samieri, Cécilia, Virtanen, Jyrki, Wood, Alexis C., Wong, Kerry, Yang, Wei-Sin, Zhou, Xia, Baylin, Ana, Boer, Jolanda M.A., Brouwer, Ingeborg A., Campos, Hannia, Chaves, Paulo H. M., Chien, Kuo-Liong, de Faire, Ulf, Djoussé, Luc, Eiriksdottir, Gudny, El-Abbadi, Naglaa, Forouhi, Nita G., Gaziano, J. Michael, Geleijnse, Johanna M., Gigante, Bruna, Giles, Graham, Guallar, Eliseo, Gudnason, Vilmundur, Harris, Tamara, Harris, William S., Helmer, Catherine, Hellenius, Mai-Lis, Hodge, Allison, Hu, Frank B., Jacques, Paul F., Jansson, Jan-Håkan, Kalsbeek, Anya, Khaw, Kay-Tee, Koh, Woon-Puay, Laakso, Markku, Leander, Karin, Lin, Hung-Ju, Lind, Lars, Luben, Robert, Luo, Juhua, McKnight, Barbara, Mursu, Jaakko, Ninomiya, Toshiharu, Overvad, Kim, Psaty, Bruce M., Rimm, Eric, Schulze, Matthias B., Siscovick, David, Skjelbo Nielsen, Michael, Smith, Albert V., Steffen, Brian T., Steffen, Lyn, Sun, Qi, Sundström, Johan, Tsai, Michael Y., Tunstall-Pedoe, Hugh, Uusitupa, Matti I. J., van Dam, Rob M., Veenstra, Jenna, Verschuren, W.M. Monique, Wareham, Nick, Willett, Walter, Woodward, Mark, Yuan, Jian-Min, Micha, Renata, Lemaitre, Rozenn N, Mozaffarian, Dariush, and Risérus, Ulf

Published
2019
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17. 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias: The Task Force for the Management of Dyslipidaemias of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS) Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR)

Author

Catapano, Alberico L., Graham, Ian, De Backer, Guy, Wiklund, Olov, Chapman, M. John, Drexel, Heinz, Hoes, Arno W., Jennings, Catriona S., Landmesser, Ulf, Pedersen, Terje R., Reiner, Željko, Riccardi, Gabriele, Taskinen, Marja-Riita, Tokgozoglu, Lale, Verschuren, W.M. Monique, Vlachopoulos, Charalambos, Wood, David A., and Zamorano, Jose Luis

Published
2016
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18. Sociodemographic, lifestyle and clinical characteristics of energy-related depression symptoms: A pooled analysis of 13,965 depressed cases in 8 Dutch cohorts

Author

Vreijling, Sarah R., primary, van Haeringen, Marije, additional, Milaneschi, Yuri, additional, Huider, Floris, additional, Bot, Mariska, additional, Amin, Najaf, additional, Beulens, Joline W., additional, Bremmer, Marijke A., additional, Elders, Petra J., additional, Galesloot, Tessel E., additional, Kiemeney, Lambertus A., additional, van Loo, Hanna M., additional, Picavet, H. Susan J., additional, Rutters, Femke, additional, van der Spek, Ashley, additional, van de Wiel, Anne M., additional, van Duijn, Cornelia, additional, Feskens, Edith J.M., additional, Hartman, Catharina A., additional, Oldehinkel, Albertine J., additional, Smit, Jan H., additional, Verschuren, W.M. Monique, additional, Willemsen, Gonneke, additional, de Geus, Eco J.C., additional, Boomsma, Dorret I., additional, Penninx, Brenda W.J.H., additional, Lamers, Femke, additional, and Jansen, Rick, additional

Published
2023
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20. 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts) Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR)

Author

Piepoli, Massimo F., Hoes, Arno W., Agewall, Stefan, Albus, Christian, Brotons, Carlos, Catapano, Alberico L., Cooney, Marie-Therese, Corrà, Ugo, Cosyns, Bernard, Deaton, Christi, Graham, Ian, Hall, Michael Stephen, Hobbs, F.D. Richard, Løchen, Maja-Lisa, Löllgen, Herbert, Marques-Vidal, Pedro, Perk, Joep, Prescott, Eva, Redon, Josep, Richter, Dimitrios J., Sattar, Naveed, Smulders, Yvo, Tiberi, Monica, Bart van der Worp, H., van Dis, Ineke, and Verschuren, W.M. Monique

Published
2016
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21. Consumption of Meat, Fish, Dairy Products, and Eggs and Risk of Ischemic Heart Disease: A Prospective Study of 7198 Incident Cases Among 409 885 Participants in the Pan-European EPIC Cohort

Author

Key, Timothy J., Appleby, Paul N., Bradbury, Kathryn E., Sweeting, Michael, Wood, Angela, Johansson, Ingegerd, Kühn, Tilman, Steur, Marinka, Weiderpass, Elisabete, Wennberg, Maria, Lund Würtz, Anne Mette, Agudo, Antonio, Andersson, Jonas, Arriola, Larraitz, Boeing, Heiner, Boer, Jolanda M.A., Bonnet, Fabrice, Boutron-Ruault, Marie-Christine, Cross, Amanda J., Ericson, Ulrika, Fagherazzi, Guy, Ferrari, Pietro, Gunter, Marc, Huerta, José María, Katzke, Verena, Khaw, Kay-Tee, Krogh, Vittorio, La Vecchia, Carlo, Matullo, Giuseppe, Moreno-Iribas, Conchi, Naska, Androniki, Nilsson, Lena Maria, Olsen, Anja, Overvad, Kim, Palli, Domenico, Panico, Salvatore, Molina-Portillo, Elena, Quirós, J. Ramón, Skeie, Guri, Sluijs, Ivonne, Sonestedt, Emily, Stepien, Magdalena, Tjønneland, Anne, Trichopoulou, Antonia, Tumino, Rosario, Tzoulaki, Ioanna, van der Schouw, Yvonne T., Verschuren, W.M. Monique, di Angelantonio, Emanuele, Langenberg, Claudia, Forouhi, Nita, Wareham, Nick, Butterworth, Adam, Riboli, Elio, and Danesh, John

Published
2019
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23. Evaluation of epigenetic and metabolomic biomarkers indicating biological age

Author

Kuiper, Lieke M., primary, Polinder-Bos, Harmke A., additional, Bizzarri, Daniele, additional, Vojinovic, Dina, additional, Vallerga, Costanza L., additional, Beekman, Marian, additional, Dollé, Martijn E.T., additional, Ghanbari, Mohsen, additional, Voortman, Trudy, additional, Reinders, Marcel J.T., additional, Verschuren, W.M. Monique, additional, Slagboom, P. Eline, additional, van den Akker, Erik B., additional, and van Meurs, Joyce B.J., additional

Published
2022
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24. Long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in a large pooled European cohort: ELAPSE study

Author

Andersen, Zorana J., primary, Zhang, Jiawei, additional, Jørgensen, Jeanette T., additional, Samoli, Evangelia, additional, Liu, Shuo, additional, Chen, Jie, additional, Strak, Maciej, additional, Wolf, Kathrin, additional, Weinmayr, Gudrun, additional, Rodopolou, Sophia, additional, Remfry, Elizabeth, additional, de Hoogh, Kees, additional, Bellander, Tom, additional, Brandt, Jørgen, additional, Concin, Hans, additional, Zitt, Emanuel, additional, Fecht, Daniela, additional, Forastiere, Francesco, additional, Gulliver, John, additional, Hoffmann, Barbara, additional, Hvidtfeldt, Ulla A., additional, Monique Verschuren, W.M., additional, Jöckel, Karl-Heinz, additional, So, Rina, additional, Cole-Hunter, Tom, additional, Mehta, Amar J., additional, Mortensen, Laust H., additional, Ketzel, Matthias, additional, Lager, Anton, additional, Leander, Karin, additional, Ljungman, Petter, additional, Severi, Gianluca, additional, Boutron-Ruault, Marie-Christine, additional, Magnusson, Patrik K.E., additional, Nagel, Gabriele, additional, Pershagen, Göran, additional, Peters, Annette, additional, Rizzuto, Debora, additional, van der Schouw, Yvonne T., additional, Schramm, Sara, additional, Stafoggia, Massimo, additional, Katsouyanni, Klea, additional, Brunekreef, Bert, additional, Hoek, Gerard, additional, and Lim, Youn-Hee, additional

Published
2022
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25. Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses

Author

Gaziano, Liam, primary, Sun, Luanluan, additional, Arnold, Matthew, additional, Bell, Steven, additional, Cho, Kelly, additional, Kaptoge, Stephen K., additional, Song, Rebecca J., additional, Burgess, Stephen, additional, Posner, Daniel C., additional, Mosconi, Katja, additional, Robinson-Cohen, Cassianne, additional, Mason, Amy M., additional, Bolton, Thomas R., additional, Tao, Ran, additional, Allara, Elias, additional, Schubert, Petra, additional, Chen, Lingyan, additional, Staley, James R., additional, Staplin, Natalie, additional, Altay, Servet, additional, Amiano, Pilar, additional, Arndt, Volker, additional, Ärnlöv, Johan, additional, Barr, Elizabeth L.M., additional, Björkelund, Cecilia, additional, Boer, Jolanda M.A., additional, Brenner, Hermann, additional, Casiglia, Edoardo, additional, Chiodini, Paolo, additional, Cooper, Jackie A., additional, Coresh, Josef, additional, Cushman, Mary, additional, Dankner, Rachel, additional, Davidson, Karina W., additional, de Jongh, Renate T., additional, Donfrancesco, Chiara, additional, Engström, Gunnar, additional, Freisling, Heinz, additional, de la Cámara, Agustín Gómez, additional, Gudnason, Vilmundur, additional, Hankey, Graeme J., additional, Hansson, Per-Olof, additional, Heath, Alicia K., additional, Hoorn, Ewout J., additional, Imano, Hironori, additional, Jassal, Simerjot K., additional, Kaaks, Rudolf, additional, Katzke, Verena, additional, Kauhanen, Jussi, additional, Kiechl, Stefan, additional, Koenig, Wolfgang, additional, Kronmal, Richard A., additional, Kyrø, Cecilie, additional, Lawlor, Deborah A., additional, Ljungberg, Börje, additional, MacDonald, Conor, additional, Masala, Giovanna, additional, Meisinger, Christa, additional, Melander, Olle, additional, Moreno Iribas, Conchi, additional, Ninomiya, Toshiharu, additional, Nitsch, Dorothea, additional, Nordestgaard, Børge G., additional, Onland-Moret, Charlotte, additional, Palmieri, Luigi, additional, Petrova, Dafina, additional, Garcia, Jose Ramón Quirós, additional, Rosengren, Annika, additional, Sacerdote, Carlotta, additional, Sakurai, Masaru, additional, Santiuste, Carmen, additional, Schulze, Matthias B., additional, Sieri, Sabina, additional, Sundström, Johan, additional, Tikhonoff, Valérie, additional, Tjønneland, Anne, additional, Tong, Tammy, additional, Tumino, Rosario, additional, Tzoulaki, Ioanna, additional, van der Schouw, Yvonne T., additional, Monique Verschuren, W.M., additional, Völzke, Henry, additional, Wallace, Robert B., additional, Wannamethee, S. Goya, additional, Weiderpass, Elisabete, additional, Willeit, Peter, additional, Woodward, Mark, additional, Yamagishi, Kazumasa, additional, Zamora-Ros, Raul, additional, Akwo, Elvis A., additional, Pyarajan, Saiju, additional, Gagnon, David R., additional, Tsao, Philip S., additional, Muralidhar, Sumitra, additional, Edwards, Todd L., additional, Damrauer, Scott M., additional, Joseph, Jacob, additional, Pennells, Lisa, additional, Wilson, Peter W.F., additional, Harrison, Seamus, additional, Gaziano, Thomas A., additional, Inouye, Michael, additional, Baigent, Colin, additional, Casas, Juan P., additional, Langenberg, Claudia, additional, Wareham, Nick, additional, Riboli, Elio, additional, Gaziano, J.Michael, additional, Danesh, John, additional, Hung, Adriana M., additional, Butterworth, Adam S., additional, Wood, Angela M., additional, Di Angelantonio, Emanuele, additional, Koettgen, Anna, additional, Shaw, Jonathan, additional, Atkins, Robert, additional, Zimmet, Paul, additional, Whincup, Peter, additional, Willeit, Johann, additional, Leitner, Christoph, additional, Tybjaerg-Hansen, Anne, additional, Schnohr, Peter, additional, Afzal, Shoaib, additional, Pablos, David Lora, additional, Arriscado, Cristina Martin, additional, Ferreiro, Carmen Romero, additional, Stocker, Hannah, additional, Schöttker, Ben, additional, Holleczek, Bernd, additional, Chetrit, Angela, additional, Welin, Lennart, additional, Svärdsudd, Kurt, additional, Lissner, Lauren, additional, Hange, Dominique, additional, Mehlig, Kirsten, additional, Nagel, Dorothea, additional, Norman, Paul E., additional, Almeida, Osvaldo, additional, Flicker, Leon, additional, Hata, Jun, additional, Honda, Takanori, additional, Furuta, Yoshihiko, additional, Iso, Hiroyasu, additional, Kitamura, Akihiko, additional, Muraki, Isao, additional, Salonen, Jukka T., additional, Tuomainen, Tomi-Pekka, additional, van Zutphen, E. M., additional, van Schoor, N. M., additional, Lo Noce, Cinzia, additional, Kronmal, Richard, additional, Lappas, Georg, additional, Nilsson, Peter M., additional, Hedblad, Bo, additional, Shaffer, Jonathan, additional, Schwartz, Joseph, additional, Shimbo, Daichi, additional, Sato, Shinichi, additional, Hayama-Terada, Mina, additional, Jassal, Simerjot, additional, Aspelund, Thor, additional, Thorsson, Bolli, additional, Sigurdsson, Gunnar, additional, Chaker, Layal, additional, Ikram, Kamran M., additional, Kavousi, Maryam, additional, Tunstall-Pedoe, Hugh, additional, Can, Günay, additional, Yüksel, Hüsniye, additional, Özkan, Uğur, additional, Nakagawa, Hideaki, additional, Morikawa, Yuko, additional, Ishizaki, Masao, additional, Feskens, Edith, additional, Geleijnse, Johanna M, additional, and Kromhout, Daan, additional

Published
2022
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26. Breast Cancer Incidence in Relation to Long-Term Low-Level Exposure to Air Pollution in the ELAPSE Pooled Cohort

Author

Hvidtfeldt, Ulla Arthur, primary, Chen, Jie, additional, Rodopoulou, Sophia, additional, Strak, Maciej, additional, de Hoogh, Kees, additional, Andersen, Zorana J., additional, Bellander, Tom, additional, Brandt, Jørgen, additional, Fecht, Daniela, additional, Forastiere, Francesco, additional, Gulliver, John, additional, Hertel, Ole, additional, Hoffmann, Barbara H., additional, Katsouyanni, Klea, additional, Ketzel, Matthias, additional, Brynedal, Boel, additional, Leander, Karin, additional, Ljungman, Petter L.S., additional, Magnusson, Patrik K.E., additional, Nagel, Gabriele, additional, Pershagen, Göran, additional, Rizzuto, Debora, additional, Boutron-Ruault, Marie-Christine, additional, Samoli, Evangelia, additional, So, Rina, additional, Stafoggia, Massimo, additional, Tjønneland, Anne, additional, Vermeulen, Roel, additional, Verschuren, W.M. Monique, additional, Weinmayr, Gudrun, additional, Wolf, Kathrin, additional, Zhang, Jiawei, additional, Zitt, Emanuel, additional, Brunekreef, Bert, additional, Hoek, Gerard, additional, and Raaschou-Nielsen, Ole, additional

Published
2022
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27. Genetically determined reproductive aging and coronary heart disease: a bidirectional two-sample Mendelian Randomization

Author

Dam, Veerle, Onland-Moret, N. Charlotte, Burgess, Stephen, Chirlaque, Maria Dolores, Peters, Sanne A.E., Schuit, Ewoud, Tikk, Kaja, Weiderpass, Elisabete, Oliver-Williams, Clare, Wood, Angela M., Tjønneland, Anne, Dahm, Christina C, Overvad, Kim, Boutron-Rualt, Marie-Christine, Schulze, Matthias B., Trichopoulou, Antonia, Ferrari, Pietro, Masala, Giovanna, Krogh, Vittorio, Tumino, Rosario, Matullo, Giuseppe, Panico, Salvatore, Boer, Jolanda M. A., Verschuren, W.M. Monique, Waaseth, Marit, Pérez, María José Sánchez, Amiano, Pilar, Imaz, Liher, Moreno-Iribas, Conchi, Melander, Olle, Harlid, Sophia, Nordendahl, Maria, Wennberg, Patrik, Key, Timothy J., Riboli, Elio, Santiuste, Carmen, Kaaks, Rudolf, Katzke, Verena, Langenberg, Claudia, Wareham, Nicholas J., Schunkert, Heribert, Erdmann, Jeanette, Willenborg, Christina, Hengstenberg, Christian, Kleber, Marcus E., Delgado, Graciela, März, Winfried, Kanoni, Stavroula, Dedoussis, George, Deloukas, Panos, Nikpay, Majid, McPherson, Ruth, Scholz, Markus, Teren, Andrej, Butterworth, Adam S., and van der Schouw, Yvonne T.

Subjects
Mendelian Randomization, Reproductive aging, coronary heart disease, risk factors, cardiovascular diseases
Abstract

Background: Accelerated reproductive aging, in women indicated by early natural menopause, is associated with increased coronary heart disease (CHD) risk in observational studies. Conversely, an adverse CHD risk profile has been suggested to accelerate menopause. Objectives: To study the direction and evidence for causality of the relationship between reproductive aging and (non-)fatal CHD and CHD risk factors in a bidirectional Mendelian randomization (MR) approach, using age at natural menopause (ANM) genetic variants as a measure for genetically determined reproductive aging in women. We also studied the association of these variants with CHD risk (factors) in men. Design: Two-sample MR, using both cohort data as well as summary statistics, with 4 methods: simple and weighted median-based, standard inverse-variance weighted (IVW) regression, and MR-Egger regression. Participants: Data from EPIC-CVD and summary statistics from UK Biobank and publicly available genome-wide association studies were pooled for the different analyses. Main Outcome Measures: CHD, CHD risk factors, and ANM. Results: Across different methods of MR, no association was found between genetically determined reproductive aging and CHD risk in women (relative risk estimateIVW = 0.99; 95% confidence interval (CI), 0.97-1.01), or any of the CHD risk factors. Similarly, no associations were found in men. Neither did the reversed analyses show evidence for an association between CHD (risk factors) and reproductive aging. Conclusion: Genetically determined reproductive aging is not causally associated with CHD risk (factors) in women, nor were the genetic variants associated in men. We found no evidence for a reverse association in a combined sample of women and men.

Published
2022

29. Type 2 Diabetes Partitioned Polygenic Scores Associate With Disease Outcomes in 454,193 Individuals Across 13 Cohorts

Author

DiCorpo, Daniel, primary, LeClair, Jessica, additional, Cole, Joanne B., additional, Sarnowski, Chloé, additional, Ahmadizar, Fariba, additional, Bielak, Lawrence F., additional, Blokstra, Anneke, additional, Bottinger, Erwin P., additional, Chaker, Layal, additional, Chen, Yii-Der I., additional, Chen, Ye, additional, de Vries, Paul S., additional, Faquih, Tariq, additional, Ghanbari, Mohsen, additional, Gudmundsdottir, Valborg, additional, Guo, Xiuqing, additional, Hasbani, Natalie R., additional, Ibi, Dorina, additional, Ikram, M. Arfan, additional, Kavousi, Maryam, additional, Leonard, Hampton L., additional, Leong, Aaron, additional, Mercader, Josep M., additional, Morrison, Alanna C., additional, Nadkarni, Girish N., additional, Nalls, Mike A., additional, Noordam, Raymond, additional, Preuss, Michael, additional, Smith, Jennifer A., additional, Trompet, Stella, additional, Vissink, Petra, additional, Yao, Jie, additional, Zhao, Wei, additional, Boerwinkle, Eric, additional, Goodarzi, Mark O., additional, Gudnason, Vilmundur, additional, Jukema, J. Wouter, additional, Kardia, Sharon L.R., additional, Loos, Ruth J.F., additional, Liu, Ching-Ti, additional, Manning, Alisa K., additional, Mook-Kanamori, Dennis, additional, Pankow, James S., additional, Picavet, H. Susan J., additional, Sattar, Naveed, additional, Simonsick, Eleanor M., additional, Verschuren, W.M. Monique, additional, Willems van Dijk, Ko, additional, Florez, Jose C., additional, Rotter, Jerome I., additional, Meigs, James B., additional, Dupuis, Josée, additional, and Udler, Miriam S., additional

Published
2022
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32. 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias

Author

Catapano, Alberico L., Graham, Ian, De Backer, Guy, Wiklund, Olov, Chapman, M. John, Drexel, Heinz, Hoes, Arno W., Jennings, Catriona S., Landmesser, Ulf, Pedersen, Terje R., Reiner, Željko, Riccardi, Gabriele, Taskinen, Marja-Riita, Tokgozoglu, Lale, Monique Verschuren, W.M., Vlachopoulos, Charalambos, Wood, David A., Luis Zamorano, Jose, and Cooney, Marie-Therese

Published
2017
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33. A new pipeline for the normalization and pooling of metabolomics data

Author

Viallon, V., His, M., Rinaldi, S., Breeur, M., Gicquiau, A., Hemon, B., Overvad, K., Tjønneland, A., Rostgaard-Hansen, A.L., Rothwell, J.A., Lecuyer, L., Severi, G., Kaaks, R., Johnson, T., Schulze, M.B., Palli, D., Agnoli, C., Panico, S., Tumino, R., Ricceri, F., Monique Verschuren, W.M., Engelfriet, P., Onland-Moret, C., Vermeulen, R., Nøst, T.H., Urbarova, I., Zamora-Ros, R., Rodriguez-Barranco, M., Amiano, P., Huerta, J.M., Ardanaz, E., Melander, O., Ottoson, F., Vidman, L., Rentoft, M., Schmidt, J.A., Travis, R.C., Weiderpass, E., Johansson, M., Dossus, L., Jenab, M., Gunter, M.J., Bermejo, J.L., Scherer, D., Salek, R.M., Keski-Rahkonen, P., Ferrari, P., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Sub Inorganic Chemistry and Catalysis, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, and Sub Inorganic Chemistry and Catalysis

Subjects
Normalization (statistics), Pooling, Computer science, Pipeline (computing), Endocrinology, Diabetes and Metabolism, computer.software_genre, Microbiology, Biochemistry, Generalized linear mixed model, Statistical power, Article, 03 medical and health sciences, Endocrinology, 0302 clinical medicine, Cancer epidemiology, Metabolites, Metabolomics, Imputation (statistics), Càncer, Molecular Biology, 030304 developmental biology, Cancer, 0303 health sciences, Cancer och onkologi, Bioinformatics (Computational Biology), Normalization, Technical variability, VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801, Missing data, QR1-502, 3. Good health, Diabetes and Metabolism, Metabolòmica, 030220 oncology & carcinogenesis, Cancer and Oncology, Outlier, Bioinformatik (beräkningsbiologi), Data mining, VDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801, computer
Abstract

Pooling metabolomics data across studies is often desirable to increase the statistical power of the analysis. However, this can raise methodological challenges as several preanalytical and analytical factors could introduce differences in measured concentrations and variability between datasets. Specifically, different studies may use variable sample types (e.g., serum versus plasma) collected, treated, and stored according to different protocols, and assayed in different laboratories using different instruments. To address these issues, a new pipeline was developed to normalize and pool metabolomics data through a set of sequential steps: (i) exclusions of the least informative observations and metabolites and removal of outliers, imputation of missing data, (ii) identification of the main sources of variability through principal component partial R-square (PC-PR2) analysis, (iii) application of linear mixed models to remove unwanted variability, including samples’ originating study and batch, and preserve biological variations while accounting for potential differences in the residual variances across studies. This pipeline was applied to targeted metabolomics data acquired using Biocrates AbsoluteIDQ kits in eight case-control studies nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Comprehensive examination of metabolomics measurements indicated that the pipeline improved the comparability of data across the studies. Our pipeline can be adapted to normalize other molecular data, including biomarkers as well as proteomics data, and could be used for pooling molecular datasets, for example in international consortia, to limit biases introduced by inter-study variability. This versatility of the pipeline makes our work of potential interest to molecular epidemiologists.

Published
2021

36. 2016 European Guidelines on cardiovascular disease prevention in clinical practice

Author

Piepoli, Massimo F., Hoes, Arno W., Agewall, Stefan, Albus, Christian, Brotons, Carlos, Catapano, Alberico L., Cooney, Marie-Therese, Corrà, Ugo, Cosyns, Bernard, Deaton, Christi, Graham, Ian, Hall, Michael Stephen, Richard Hobbs, F.D., Løchen, Maja-Lisa, Löllgen, Herbert, Marques-Vidal, Pedro, Perk, Joep, Prescott, Eva, Redon, Josep, Richter, Dimitrios J., Sattar, Naveed, Smulders, Yvo, Tiberi, Monica, Bart van der Worp, H., van Dis, Ineke, and Monique Verschuren, W.M.

Published
2016
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40. FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals

Author

Qi, Qibin, Kilpeläinen, Tuomas O., Downer, Mary K., Tanaka, Toshiko, Smith, Caren E., Sluijs, Ivonne, Sonestedt, Emily, Chu, Audrey Y., Renström, Frida, Lin, Xiaochen, Ängquist, Lars H., Huang, Jinyan, Liu, Zhonghua, Li, Yanping, Asif Ali, Muhammad, Xu, Min, Ahluwalia, Tarunveer Singh, Boer, Jolanda M.A., Chen, Peng, Daimon, Makoto, Eriksson, Johan, Perola, Markus, Friedlander, Yechiel, Gao, Yu-Tang, Heppe, Denise H.M., Holloway, John W., Houston, Denise K., Kanoni, Stavroula, Kim, Yu-Mi, Laaksonen, Maarit A., Jääskeläinen, Tiina, Lee, Nanette R., Lehtimäki, Terho, Lemaitre, Rozenn N., Lu, Wei, Luben, Robert N., Manichaikul, Ani, Männistö, Satu, Marques-Vidal, Pedro, Monda, Keri L., Ngwa, Julius S., Perusse, Louis, van Rooij, Frank J.A., Xiang, Yong-Bing, Wen, Wanqing, Wojczynski, Mary K, Zhu, Jingwen, Borecki, Ingrid B., Bouchard, Claude, Cai, Qiuyin, Cooper, Cyrus, Dedoussis, George V., Deloukas, Panos, Ferrucci, Luigi, Forouhi, Nita G., Hansen, Torben, Christiansen, Lene, Hofman, Albert, Johansson, Ingegerd, Jørgensen, Torben, Karasawa, Shigeru, Khaw, Kay-Tee, Kim, Mi-Kyung, Kristiansson, Kati, Li, Huaixing, Lin, Xu, Liu, Yongmei, Lohman, Kurt K., Long, Jirong, Mikkilä, Vera, Mozaffarian, Dariush, North, Kari, Pedersen, Oluf, Raitakari, Olli, Rissanen, Harri, Tuomilehto, Jaakko, van der Schouw, Yvonne T., Uitterlinden, André G., Zillikens, M. Carola, Franco, Oscar H., Shyong Tai, E., Ou Shu, Xiao, Siscovick, David S., Toft, Ulla, Verschuren, W.M. Monique, Vollenweider, Peter, Wareham, Nicholas J., Witteman, Jacqueline C.M., Zheng, Wei, Ridker, Paul M., Kang, Jae H., Liang, Liming, Jensen, Majken K., Curhan, Gary C., Pasquale, Louis R., Hunter, David J., Mohlke, Karen L., Uusitupa, Matti, Cupples, L. Adrienne, Rankinen, Tuomo, Orho-Melander, Marju, Wang, Tao, Chasman, Daniel I., Franks, Paul W., Sørensen, Thorkild I.A., Hu, Frank B., Loos, Ruth J. F., Nettleton, Jennifer A., and Qi, Lu

Published
2014
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41. Marine (n-3) fatty acids, fish consumption, and the 10-year risk of fatal and nonfatal coronary heart disease in a large population of dutch adults with low fish intake

Author

de Goede, Janette, Geleijnse, Johanna M., Boer, Jolanda M.A., Kromhout, Daan, and Verschuren, W.M. Monique

Subjects
Omega-3 fatty acids -- Health aspects, Heart attack -- Prevention, Fish as food -- Nutritional aspects, Food/cooking/nutrition
Abstract

We assessed the dose-response relations within a low range of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and fish intake on fatal coronary heart disease (CHD) and nonfatal myocardial infarction (MI). In a Dutch population- based cohort study, EPA+DHA and fish intake were assessed at baseline among 21,342 participants aged 20-65 y with no history of MI or stroke. Hazard ratios were calculated with Cox proportional-hazard models. During 9-14 y of follow-up (mean 11.3 y), 647 participants (3%) died, of which 82 of CHD. Fatal CHD mainly comprised MI (64 cases). In total, 252 participants survived an MI. Median intakes in quartiles of EPA+DHA were 40, 84, 151, and 234 mg/d. Medians of fish consumption in quartiles were 1.1,4.2, 10.7, and 17.3 g/d. Compared with the lowest quartile of EPA+DHA, participants in the top quartile had a 49% lower risk of fatal CHD (95% CI: 6-73%) and a 62% lower risk of fatal MI (95% CI: 23-81%). We observed inverse dose-response relations for EPA+DHA intake and fatal CHD (P-trend = 0.05) and fatal MI (P-trend = 0.01 ). Results were similar for fish consumption. Nonfatal MI was not associated with EPA+DHA or fish intake. In conclusion, in populations with a low fish consumption, EPA+DHA and fish may lower fatal CHD and MI risk in a dose-responsive manner. Low intakes of EPA+DHA or fish do not seem to protect against nonfatal MI. doi: 10.3945/jn.109.119271.

Published
2010

42. Matrix Gla protein species and risk of cardiovascular events in type 2 diabetic patients

Author

Dalmeijer, Geertje W., Van Der Schouw, Yvonne T., Magdeleyns, Elke J., Vermeer, Cees, Verschuren, W.M. Monique, Boer, Jolanda M.A., and Beulens, Joline W.J.

Subjects
Cholesterol, Coronary heart disease -- Risk factors, Diabetes -- Risk factors, Enzyme-linked immunosorbent assay, Diabetics, Heart failure -- Risk factors, Health
Abstract

OBJECTIVE--To investigate the relationship of circulating matrix Gla protein (MGP) species with incident cardiovascular disease (CVD) or coronary heart disease (CHD) in type 2 diabetic patients. RESEARCH DESIGN AND METHODS--EPIC-NL [...]

Published
2013
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43. Dairy intake, blood pressure, and incident hypertension in a general Dutch population

Author

Engberink, Marielle F., Geleijnse, Johanna M., de Jong, Nynke, Smit, Henriette A., Kok, Frans J., and Verschuren, W.M. Monique

Subjects
Hypertension -- Risk factors, Diet -- Health aspects, Blood pressure -- Research, Life style -- Health aspects, Dutch -- Health aspects, Dutch -- Food and nutrition, Food/cooking/nutrition
Abstract

Diet and lifestyle are important for maintaining a healthy blood pressure (BP). The role of dairy in the prevention of hypertension, however, is not yet clear. We studied the relation of dairy intake with BP in 21,553 Dutch participants aged 20-65 y who did not use antihypertensive medication. In addition, the risk of hypertension was examined in 3454 of these participants with a 5-y follow-up. Dairy consumption was assessed at baseline (1993-1997) using a semiquantitative FFQ that included 178 foods and beverages. Baseline BP and odds ratios (QR) (95% CI) for incident hypertension were calculated in categories of energy-adjusted dairy intake with adjustment for age, sex, socioeconomic status, BMI, smoking, alcohol use, and dietary intakes. Participants had a median intake of 344 g/d (~2.3 servings) for total dairy and 174 g/d (~1.2 servings) for low-fat dairy. Mean BP was 120/76 mm Hg. Intake of total dairy, specific dairy groups (i.e. low-fat, high-fat, fermented) and dairy products (i.e. cheese, yogurt) were not consistently related to BP. Of 3454 participants who were followed, 713 developed hypertension. The risk of hypertension tended to be inversely related to low-fat dairy intake, with multivariate OR (95% CI) of 1.00, 0.78 (0.61, 1.00), 0.81 (0.63, 1.03), and 0.82 (0.64, 1.06; P-trend: 0.24) in consecutive quartiles. We conclude that variations in BP in a general middle-aged Dutch population cannot be explained by overall dairy intake. A beneficial effect of low-fat dairy on risk of hypertension, however, cannot be excluded, which warrants further investigation in prospective population-based studies.

Published
2009

44. Anti-Müllerian Hormone Levels and Risk of Cancer in Women

Author

Verdiesen, Renée M.G., primary, van Gils, Carla H., additional, Stellato, Rebecca K., additional, Verschuren, W.M. Monique, additional, Broekmans, Frank J.M., additional, de Kat, Annelien C., additional, van der Schouw, Yvonne T., additional, and Onland-Moret, N. Charlotte, additional

Published
2021
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46. Smoking and cognitive decline among middle-aged men and women: the Doetinchem Cohort Study

Author

Nooyens, Astrid C.J., van Gelder, Boukje M., and Verschuren, W.M. Monique

Subjects
Smoking -- Health aspects, Smoking -- Psychological aspects, Cognition disorders -- Risk factors, Cognition disorders -- Research, Middle age -- Health aspects, Middle age -- Psychological aspects, Government, Health care industry
Abstract

Objectives. We studied the effect of smoking on cognitive decline over a 5-year period at middle age (43 to 70 years). Methods. In the Doetinchem Cohort Study, 1964 men and women in the Netherlands were examined for cognitive function at baseline and 5 years later. The association between smoking status and memory function, speed of cognitive processes, cognitive flexibility, and global cognitive function were assessed. Results. At baseline, smokers scored lower than never smokers in global cognitive function, speed, and flexibility. At 5-year follow-up, decline among smokers was 1.9 times greater for memory function, 2.4 times greater for cognitive flexibility, and 1.7 times greater for global cognitive function than among never smokers. Among ever smokers, the declines in all cognitive domains were larger with increasing number of pack-years smoked. Conclusions. Interventions to prevent or stop people from smoking may postpone cognitive decline in middle-aged persons. doi:10.2105/AJPH.2007.130294

Published
2008

47. Association between nutritional profiles of foods underlying Nutri-Score front-of-pack labels and mortality: EPIC cohort study in 10 European countries

Author

Deschasaux, M. Huybrechts, I. Julia, C. Hercberg, S. Egnell, M. Srour, B. Kesse-Guyot, E. Latino-Martel, P. Biessy, C. Casagrande, C. Murphy, N. Jenab, M. Ward, H.A. Weiderpass, E. Overvad, K. Tjønneland, A. Rostgaard-Hansen, A.L. Boutron-Ruault, M.-C. Mancini, F.R. Mahamat-Saleh, Y. Kühn, T. Katzke, V. Bergmann, M.M. Schulze, M.B. Trichopoulou, A. Karakatsani, A. Peppa, E. Masala, G. Agnoli, C. De Magistris, M.S. Tumino, R. Sacerdote, C. Boer, J.M.A. Monique Verschuren, W.M. Van Der Schouw, Y.T. Skeie, G. Braaten, T. Luisa Redondo, M. Agudo, A. Petrova, D. Colorado-Yohar, S.M. Barricarte, A. Amiano, P. Sonestedt, E. Ericson, U. Otten, J. Sundström, B. Wareham, N.J. Forouhi, N.G. Vineis, P. Tsilidis, K.K. Knuppel, A. Papier, K. Ferrari, P. Riboli, E. Gunter, M.J. Touvier, M.

Abstract

Objective To determine if the Food Standards Agency nutrient profiling system (FSAm-NPS), which grades the nutritional quality of food products and is used to derive the Nutri-Score front-of-packet label to guide consumers towards healthier food choices, is associated with mortality. Design Population based cohort study. Setting European Prospective Investigation into Cancer and Nutrition (EPIC) cohort from 23 centres in 10 European countries. Participants 521 324 adults; at recruitment, country specific and validated dietary questionnaires were used to assess their usual dietary intakes. A FSAm-NPS score was calculated for each food item per 100 g content of energy, sugars, saturated fatty acids, sodium, fibre, and protein, and of fruit, vegetables, legumes, and nuts. The FSAm-NPS dietary index was calculated for each participant as an energy weighted mean of the FSAm-NPS score of all foods consumed. The higher the score the lower the overall nutritional quality of the diet. Main outcome measure Associations between the FSAm-NPS dietary index score and mortality, assessed using multivariable adjusted Cox proportional hazards regression models. Results After exclusions, 501 594 adults (median follow-up 17.2 years, 8 162 730 person years) were included in the analyses. Those with a higher FSAm-NPS dietary index score (highest versus lowest fifth) showed an increased risk of all cause mortality (n=53 112 events from non-external causes; hazard ratio 1.07, 95% confidence interval 1.03 to 1.10, P

Published
2020

48. Glycemic index, glycemic load, and risk of coronary heart disease: A pan-European cohort study

Author

Sieri, S. Agnoli, C. Grioni, S. Weiderpass, E. Mattiello, A. Sluijs, I. Sanchez, M.J. Jakobsen, M.U. Sweeting, M. van der Schouw, Y.T. Nilsson, L.M. Wennberg, P. Katzke, V.A. Kühn, T. Overvad, K. Tong, T.Y.N. Conchi, M.-I. Quirós, J.R. García-Torrecillas, J.M. Mokoroa, O. Gómez, J.-H. Tjønneland, A. Sonestedt, E. Trichopoulou, A. Karakatsani, A. Valanou, E. Boer, J.M.A. Monique Verschuren, W.M. Boutron-Ruault, M.-C. Fagherazzi, G. Madika, A.-L. Bergmann, M.M. Schulze, M.B. Ferrari, P. Freisling, H. Lennon, H. Sacerdote, C. Masala, G. Tumino, R. Riboli, E. Wareham, N.J. Danesh, J. Forouhi, N.G. Butterworth, A.S. Krogh, V.

Abstract

Background: High carbohydrate intake raises blood triglycerides, glucose, and insulin; reduces HDLs; and may increase risk of coronary heart disease (CHD). Epidemiological studies indicate that high dietary glycemic index (GI) and glycemic load (GL) are associated with increased CHD risk. Objectives: The aim of this study was to determine whether dietary GI, GL, and available carbohydrates are associated with CHD risk in both sexes. Methods: This large prospective study-the European Prospective Investigation into Cancer and Nutrition-consisted of 338,325 participants who completed a dietary questionnaire. HRs with 95% CIs for a CHD event, in relation to intake of GI, GL, and carbohydrates, were estimated using covariate-adjusted Cox proportional hazard models. Results: After 12.8 y (median), 6378 participants had experienced a CHD event. High GL was associated with greater CHD risk [HR 1.16 (95% CI: 1.02, 1.31) highest vs. lowest quintile, p-trend 0.035; HR 1.18 (95% CI: 1.07, 1.29) per 50 g/day of GL intake]. The association between GL and CHD risk was evident in subjects with BMI (in kg/m2) =25 [HR: 1.22 (95% CI: 1.11, 1.35) per 50 g/d] but not in those with BMI

Published
2020

49. Customary use of plant sterol and plant stanol enriched margarine is associated with changes in serum plant sterol and stanol concentrations in humans

Author

Fransen, Heidi P., de Jong, Nynke, Wolfs, Marion, Verhagen, Hans, Verschuren, W.M. Monique, Lutjohann, Dieter, von Bergmann, Klaus, Plat, Jogchum, and Mensink, Ronald P.

Subjects
Blood cholesterol -- Observations, Phytosterols -- Nutritional aspects, Sterols -- Research, Food research, Food/cooking/nutrition
Abstract

The consumption of products enriched with plant sterol or stanol esters lowers serum total and LDL-cholesterol concentrations, thereby most likely reducing the risk of coronary heart disease. However, using plant sterol (not plant stanol) enriched products elevates serum plant sterol concentrations in humans. This may be unwanted because health effects of elevated serum plant sterol concentrations are still controversial. Within postlaunch monitoring of functional foods, we compared serum plant sterol and plant stanol concentrations among users of plant sterol (n = 67) or plant stanol (n = 13) enriched margarines with those of matched nonusers (n = 81) in the ongoing Dutch Doetinchem cohort study. Subjects (aged 29-67 y) were examined in 1994-1998 (before the introduction of enriched margarines) and re-examined in 1999-2003. Serum concentrations of plant sterols and stanols were measured in samples from nonfasting subjects by GLC-MS. Intake of plant sterols was 1.1 [+ or -] 0.6 g/d and was associated with a decrease of serumtotal cholesterol concentration of 0.25 [+ or -] 0.91 mmol/L (4%, P < 0.05), a change that differed (P < 0.05) from the nonsignificant increase in nonusers (+2 %, 0.12 [+ or -] 0.78 mmol/L, P = 0.16). Cholesterol-standardized serum sitosterol and campesterol increased in plant sterol users by 22% (P< 0.0001) and 103% (P< 0.0001), respectively. Cholesterol-standardized serum sitostanol and campestanol increased in plant stanol users by 197% (P = 0.02) and 196% (P = 0.01). To our knowledge, these data are the first to show changes in serum cholesterol, plant sterol, and plant stanol concentrations after (long-term) consumption of plant sterol and stanol enriched margarines in a free-living population in a nonexperimental setting. Whether the increased serum sterol concentrations result in adverse side effects needs to be investigated in future postlaunch monitoring studies.

Published
2007

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