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122 results on '"Versaci, Antonino"'

7. [Gastrointestinal stromal tumour: our experience]

Author

Versaci, Antonino, Macri', Antonio, Ieni, Antonio, Terranova, Maria Luisa, Leonello, Grazia, Saladino, Edoardo, Speciale, Giuseppe, and Famulari, Ciro

Subjects
Male, Jejunal Neoplasms, Gastrointestinal Stromal Tumors, gastrointestinal stromal tumour (GIST), Antineoplastic Agents, Middle Aged, Survival Analysis, Piperazines, Ileal Neoplasms, Pyrimidines, Treatment Outcome, imatinib mesylate, Chemotherapy, Adjuvant, Stomach Neoplasms, Benzamides, Colonic Neoplasms, Imatinib Mesylate, Humans, Female, Aged, Follow-Up Studies, Retrospective Studies
Abstract

Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. These tumours originate in Cajal interstitial cells and the majority are located in the stomach and small intestine. They frequently develop in males aged 50-60 years. The symptoms of GIST are non-specific and depend on the size and location of the lesion. Imaging difficulties impede an early diagnosis; sometimes these tumours represent an unexpected intraoperative finding or an emergency abdominal picture. GISTs are classified as tumours with low- and high-risk of malignancy, depending on tumour size and mitotic count. Tumour site and acute onset are also significant parameters for prognostic purposes. Fifteen patients with GIST - gastric in 7 cases, ileal in 6, jejunal in 1 and colonic in 1 - were treated surgically and, in 9 cases, with adjuvant therapy (chemotherapy in 4 patients and imatinib mesylate in 5). The mean follow-up was 38 months. No postoperative mortality was recorded, and the morbidity was 13.3%. Histological examinations documented 6 benign tumours and 9 malignancies. Two patients, one with gastric and one with colonic GIST, were lost to follow-up. One patient, with two synchronous gastric neoplasms (GIST + adenocarcinoma) died after 16 months, while the other 5 patients with gastric GIST are still alive; two patients with ileal GIST, treated with chemotherapy, died after 15 and 18 months, respectively. The mean survival of patients treated with imatinib mesylate was 36 months. Surgical management and the use of imatinib constitute the therapeutic gold standard for GIST. The use of imatinib mesylate is recommended today in the treatment of advanced GIST, especially in cases with liver and peritoneal metastases.

Published
2009

8. Evaluation of quality of life of patients submitted to cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal carcinosis of gastrointestinal and ovarian origin and identification of factors influencing outcome

Author

Macri', Antonio, Maugeri, Ilaria, Trimarchi, Giuseppe, Caminiti, Rocco, Saffioti, MARIA CRISTINA, Incardona, Salvatore, Sinardi, Angelo, Irato, Stefano, Altavilla, Giuseppe, Adamo, Vincenzo, Versaci, Antonino, and Famulari, Ciro

Subjects
Quality of life, Hyperthermic intraperitoneal chemotherapy, Peritoneal carcinosis, Ovarian cancer, Cytoreductive surgery, Gastric cancer, Colon cancer
Published
2009

22. [Diagnostic and therapeutic implications in two cases of pancreatic cystic tumours: mucinous and serous]

Author

Versaci, Antonino, Macri', Antonio, Scuderi, G, Ascenti, Giorgio, Crescenti, F, Sfuncia, G, Grosso, Maddalena, and Famulari, Ciro

Subjects
Diagnosis, Differential, Pancreatic Neoplasms, Pancreatectomy, Treatment Outcome, Cystadenoma, Mucinous, Cystadenoma, Serous, Biomarkers, Tumor, Humans, Antigens, Tumor-Associated, Carbohydrate, Female, Middle Aged, Immunohistochemistry, Aged
Abstract

Cystic tumours of the pancreas include a pathologically heterogeneous and rare group of tumours, which however have many common clinical features. They represent about 10% of pancreatic cystic lesions and 1% of all forms of neoplasms, thus having a certain relevance in organ surgery. So far two distinct categories of cystic tumours have been identified, the basically benign serous form and the potentially malign mucinous form, which may sometimes show malignant features as early as the diagnostic stage. As neoplasms are very difficult to interpret before operation, it is essential that diagnosis is as accurate as possible in order to streamline surgery, which will have to be carried out after histological tests have been performed on an adequate number of tumour sections. Basing on these two cases of cystic tumours of the pancreas and on current literature, the Authors discuss the effectiveness of imaging techniques, such as contrast echography, dosage of specific tumour markers and histological tests backed up by immunohistochemistry in identifying these neoplasms, in order to study this rare but interesting pathology more accurately.

Published
2005

38. The Allgrove syndrome

Author

Macri', Antonio, Scuderi, G, Terranova, Maria Luisa, Leonello, G, Mastrojeni, Claudio, and Versaci, Antonino

Published
2001

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