424 results on '"Verruciform xanthoma"'
Search Results
2. A Case of Verruciform Xanthoma of Labia in a Child
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He M, Liu M, and Tao X
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verruciform xanthoma ,labia ,child ,diagnose ,treatment ,Dermatology ,RL1-803 - Abstract
Meihua He,1– 5,* Mingqiang Liu,1– 5,* Xiaohua Tao1– 5,* 1Dermatology Hospital of Jiangxi Province, Nanchang, Jiangxi, People’s Republic of China; 2Jiangxi Provincial Clinical Research Center For Skin Diseases, Nanchang, Jiangxi, People’s Republic of China; 3Candidate Branch of National Clinical Research Center for Skin Diseases, Nanchang, Jiangxi, People’s Republic of China; 4Dermatology Institute of Jiangxi Province, Nanchang, Jiangxi, People’s Republic of China; 5The Affiliated Dermatology Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaohua Tao, Department of Dermatology, Dermatology Hospital of Jiangxi Province, Nanchang, Jiangxi, 330001, People’s Republic of China, Tel +86 15979086756, Fax +86-0791-85207512, Email taoxiaohua@126.comPurpose: Verruciform xanthoma (VX) is a rare, chronic, and benign lesion affecting the skin and mucous membranes. We reported a case of VX in the vulva of a female child.Patients and Methods: A 12-year-old female had vulvar lesions for over 10 years without any discomfort. Physical examination revealed red lobulated patches on the left labia majora with a few scales attached to the surface. Histopathological examination indicated excessive and incomplete keratinization, hypertrophic spinous layer hyperplasia, neutrophil infiltration in the epidermis, and foam-like tissue could be seen in the dermal papilla. Lymphocyte-dominated inflammatory cell infiltration was scattered around the blood vessels. Immunohistochemical results showed positive CD68.Results: The final diagnosis confirmed the presence of VX.Conclusion: Surgical intervention proved successful in achieving favorable outcomes for the patient.Plain Language Summary: Verruciform xanthoma (VX) is a rare and non-cancerous skin condition that usually appears in the mouth but can occur on the genitals. In this case, a 12-year-old girl had red, warty lesions on her left labia majora for over 10 years. The cause of VX is not well understood but may be linked to inflammation, trauma, or immune disorders rather than lipid metabolism. The girl’s condition was confirmed through a biopsy, and she underwent surgical removal with no recurrence after a year. VX in the genital area is known as Vegas xanthomas. Though VX can look like other skin issues, a detailed examination of tissue samples is crucial for an accurate diagnosis. Treatment options include surgery, laser therapy, or topical creams. While VX is generally benign, seeking medical attention is important to rule out other concerns.Keywords: verruciform xanthoma, labia, child, diagnose, treatment
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- 2024
3. Verruciform Xanthoma Presenting Within an Ear Piercing.
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Myers, Hannah E., Rangarajan, Subhapradha, Roberts, Michael, Buckley, Christopher, and Hammel, Josh
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Verruciform xanthomas are rare lesions affecting 0.025-0.5% of the population. They present as an asymptomatic, slow growing solitary lesion on the oral mucosa. Commonly misdiagnose as squamous cell carcinoma, verruca vulgaris, leukoplakia, and lichen planus. Presented is a 22 year old male with a painful verruciform xanthoma on the posterior ear lobe in a prior ear piercing. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Verruciform xanthoma on the anterior maxillary gingiva.
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Wu, Yu-Hsueh, Yu-Fong Chang, Julia, Jin, Ying-Tai, and Chiang, Chun-Pin
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GINGIVA ,INTERDENTAL papilla ,MACROPHAGES - Published
- 2024
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5. Verruciform xanthoma on the maxillary gingiva.
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Hwang, Ming-Jay, Chang, Julia Yu-Fong, Jin, Ying-Tai, and Chiang, Chun-Pin
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GINGIVA ,MACROPHAGES - Published
- 2024
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6. Verruciform Xanthoma: Clinical and Morphologic Spectrum Across Oral, Genital, and Cutaneous Sites.
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Javadi, Tiffany, Saeed, Faisel, Parker, Douglas C., and Magliocca, Kelly R.
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Background: Verruciform xanthoma (VX) is an uncommon, benign epithelial lesion of the oral mucosa. While this entity can also present extraorally, including on the skin and in anogenital areas, the variation in its histologic features in extraoral sites is not yet well defined. Differences in the demographics and morphologic features of oral versus extraoral VX were assessed to help facilitate the accurate diagnosis and management of this lesion. Methods: After obtaining IRB approval, 110 cases of diagnosed VX were retrospectively collected from our institutional archives spanning from 2000 to 2022. Patient age, gender, available medical history, lesion appearance, and duration were obtained for each case. Results: The median age was 55 years (range 13–86) with a male-to-female ratio of 1.2:1. The most common oral sites, in descending order, were the palate (n = 24, 22%), buccal mucosa (n = 18, 16%), gingiva (n = 16, 15%), and tongue (n = 13, 12%). Extraoral sites comprised 9% of all lesions, including the scrotum (9), vulva (2), cheek (1), wrist (1), gluteal region (1), and abdominal wall (1). The median size for all lesions was 6.0 mm, and extraoral lesions were associated with a 6.7 mm larger size compared to oral lesions (B ± SE: 6.7 ± 2.5 cm, p = 0.01). The lesions were most frequently pink or white in color and often described as papillary, pedunculated, verrucous, and/or exophytic. Microscopically, the presence of wedge-shaped parakeratosis, keratin projections above the epithelium/epidermis, and associated inflammation significantly differed between oral and extraoral lesions. Prominent wedge-shaped parakeratosis (p = 0.04) and keratin projections above the epithelium/epidermis (p < 0.001) were more prevalent in extraoral lesions. There was no significant link between keratin projections and epithelial atypia (p = 0.44). Conclusions: Familiarity with the broad morphological spectrum of VX, including the presence and degree of wedge-shaped parakeratosis, keratin projections above the epithelium/epidermis, and associated underlying inflammation, will be helpful in diagnosing it in unusual locations. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Oral verruciform xanthoma: Case report
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Ming-Jay Hwang, Julia Yu-Fong Chang, Chun-Pin Chiang, and Ying-Tai Jin
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Verruciform xanthoma ,Gingiva ,Macrophage ,Dentistry ,RK1-715 - Published
- 2023
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8. The Genital, Perianal, and Umbilical Regions
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Kumar, Piyush, Khare, Sanjay, Rathod, Santoshdev P., Nimisha, Esther, Khoja, Meenaz, Kulkarni, Sandeep, Tiwary, Anup Kumar, Madke, Bhushan, Smoller, Bruce, editor, and Bagherani, Nooshin, editor
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- 2022
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9. Oral potentially malignant disorders: a practical review for the diagnostic pathologist.
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Bates, Timothy John, Richards, Andrea, and Pring, Miranda
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This article provides a broad overview of oral potentially malignant disorders (OPMD) and associated entities. The review opens with an update on the terminology surrounding OPMD before summarizing the lesions and conditions currently recognized as OPMD by the World Health Organization (WHO). Approaches to diagnosing oral epithelial dysplasia (OED) are discussed in the context of the WHO's recently modified architectural and cytological criteria for OED. The spectrum of reactive epithelial changes – which may mimic OED - is explored for comparison. The review then focuses on four significant OPMD - proliferative verrucous leukoplakia, oral submucous fibrosis, HPV-associated OED, and oral lichen planus – with clinical and histopathological examples. Next, potential pitfalls - non-preneoplastic lesions that can mimic OPMD clinically and histopathologically - are highlighted; these include chronic hyperplastic candidosis, verruciform xanthoma, granular cell tumour, and hairy leukoplakia. Molecular tests for identifying and stratifying OPMD are commented on briefly as - to date - histopathology remains the most reliable prognosticator. Clinicopathological correlation is critical to accurate histopathological diagnosis, risk stratification, and clinical management. The review closes by highlighting clinical features – e.g., associated redness – indicative of high risk. [ABSTRACT FROM AUTHOR]
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- 2023
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10. Vulvar Verruciform Xanthoma: A Comprehensive Literature Review
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Wu W, Sun L, Lu J, Yang X, Liu Q, and Wang J
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verruciform xanthoma ,vulvar ,clinical features ,immunohistochemistry ,treatment ,etiology ,Dermatology ,RL1-803 - Abstract
Weiwei Wu,1,* Lengbing Sun,2,3,* Jiejie Lu,2 Xianxu Yang,2 Qiao Liu,3,4 Junzhi Wang5 1Department of Plastic and Dermatological Surgery, The Fifth People’s Hospital of Hainan Province, Haikou, People’s Republic of China; 2Department of Dermatology, The Fifth People’s Hospital of Hainan Province, Haikou, People’s Republic of China; 3School of Clinical Medicine, Jiangxi University of Chinese Medicine, Nanchang, People’s Republic of China; 4Department of Dermatology,The Second Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, People’s Republic of China; 5First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qiao Liu; Junzhi Wang, Email drliuqiao@163.com; drvolodia@163.comAbstract: Verruciform xanthoma (VX) is a rare, benign, mucocutaneous, verrucous, papillary lesion. This paper retrospectively summarizes clinical and pathologic features of 32 vulvar verruciform xanthoma reported from China and abroad. The skin lesions are generally single, mainly in labia minora, clitoris and fourchette with partly extending to the groin, buttocks and anus. The possible inducing factors include long-term scratching, local itching, severe lymphedema or lymphangioma circumscriptum. Severe cutaneous trauma and chronic inflammation may be the main causes. Clinically, it can easily be misdiagnosed as condylomata acuminata, squamous cell carcinoma, bowenoid papulosis, etc. It is reported to be related to underlying disorders. The main treatment is complete resection.Keywords: verruciform xanthoma, vulvar, clinical features, immunohistochemistry, treatment, etiology
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- 2022
11. Histopathology of Oral Hyperplastic and Neoplastic Lesions
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Krahl, Dieter, Rose, Christian, and Schmidt, Enno, editor
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- 2021
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12. AN UNUSUAL CASE OF PENILE TUMOR: GIANT SIZED VERRUCIFORM XANTHOMA OF PENIS
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Aditya Yogarama and Josep Joko Hendratno
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Penile ,verruciform xanthoma ,tumor ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Objective: This study aims to present a case of Verruciform Xanthoma (VX) on penile shaft. Case(s) Presentation: A 60 years old man was admitted to our hospital with a large sized (8cm) cauliflower like tumor on his penile shaft which started to appear 2 years prior to hospital admission. The tumor was continuously getting bigger during that period. The man did not feel any other signs and symptoms. Incision biopsy sample was taken and the histopathologic result was Verruciform Xanthoma. Then the patient took excision circumcision surgery. Discussion: Penile VX is a benign, asymptomatic, warty lesion that can occur in penile shaft, glans, coronal sulcus, and preputium. Its pathological mechanism is still unclear but the most accepted theories are mucocutaneous reaction to localized trauma and chronic inflammation. Due to its atypical appearance, it can be mistaken as other lesion, even a malignant one. Histopathological examination must be done to confirm diagnosis, and to plan the right treatment. We conduct excision and circumcision to compensate a wide skin loss and achieved satisfactory result. Conclusion: Penile VX can be mistaken as a malignant lesion, thus histopathological examination must be done to avoid over radical treatment. Excision and circumcision surgery for large sized penile VX achieve satisfactory result. Keywords: Penile, verruciform xanthoma, tumor.
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- 2023
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13. Oral Verruciform Xanthoma of the Lower Lip: A Rare Entity.
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Chatterjee A, Purkait SK, Banerjee I, Banerjee A, and Ramalingam K
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Oral verruciform xanthoma (OVX) is a rare entity, and only a handful of cases have been reported in the literature to date. This innocent-looking lesion can mimic any benign epithelial or connective tissue origin neoplasm. It can present with variations in surface color and texture. Cases have been reported in intra-osseous and extra-osseous sites, mainly in masticatory mucosa and very few in non-keratinized mucosal sites. Literature suggests the xanthoma cells possess a monocyte/macrophage lineage, although the exact etiopathogenesis remains unclear. Our patient was a 20-year-old male who presented with a soft, keratotic growth in the lower lip. It clinically mimicked a mucocele or a traumatic fibroma until the mystery was resolved by histopathology and immunohistochemistry. Histopathology revealed numerous foamy, granular xanthoma cells in the stroma along with inflammation and hyperplastic epithelium. Immunohistochemistry showed positivity to CD68 and Cathepsin-B but negative to S-100. The final diagnosis was made as oral verruciform xanthoma. It was surgically excised and remained recurrence-free on follow-up., Competing Interests: Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Chatterjee et al.)
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- 2024
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14. Diverse Roles of Macrophages in Oral Inflammatory and Benign Lesions - A Narrative Review.
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Desai, Karishma M., Kheur, Supriya, Ghoshal, Sushmita, and Govindool, Sharaschandra Reddy
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ORAL mucosa ,DATABASE searching ,ELECTRONIC information resource searching ,MACROPHAGES ,MOUTH - Abstract
Background: Macrophages are immune cells with diverse profiles and functions. Macrophages play significant roles in the repair and resolution of inflammatory and reactive lesions. They secrete cytokines and modulate the tissue microenvironment and surrounding cellular responses. Objectives: The present article reviews the histological presentation and role of macrophages in the pathogenesis of oral inflammatory and benign lesion. Materials and Methods: Data was collected by electronic search of databases including PubMed and Google Scholar for Macrophages, Periapical Granuloma, Mucocele, and Verruciform Xanthoma. Result: Distinct profiles of macrophages participate in regulation of pathogenesis, lesion size, and resolution of periapical lesions. In trauma-associated reactive or benign lesions, macrophages show phagocytosis and exhibit characteristic foamy histological appearance. The immunohistochemical profiles of macrophages aid in identifying the surface receptors and profiles of macrophages in oral lesions. Conclusion: Identifying and understanding macrophage-mediated pathogenesis can help diagnose and develop targeted therapies against various oral lesions. [ABSTRACT FROM AUTHOR]
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- 2022
15. Oral verruciform xanthoma: Case report.
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Hwang, Ming-Jay, Yu-Fong Chang, Julia, Chiang, Chun-Pin, and Jin, Ying-Tai
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MACROPHAGES - Published
- 2023
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16. Preputial Xanthoma and Rare Preputial Tumors
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Fahmy, Mohamed A. Baky and Fahmy, Mohamed A. Baky
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- 2020
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17. Oral Cavity
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Betz, Sasha Jane, Padilla, Ricardo J., Lin, Fan, Series Editor, Yang, Ximing J., Series Editor, Elliott Range, Danielle, editor, and “Sara” Jiang, Xiaoyin, editor
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- 2019
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18. Verruciform Xanthoma of the Ventral Surface of the Tongue: A Rare Case Report and Literature Review
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Saedeh Atarbashi Moghadam, Ali Lotfi, Farnoush Kabiri, and Soran Sijanivandi
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benign ,oral cavity ,tongue ,verruciform xanthoma ,Otorhinolaryngology ,RF1-547 - Abstract
Introduction: Verruciform xanthoma (VX) is an uncommon benign lesion with the subepithelial accumulation of foamy histiocytes and superficial papillary proliferations with a bright orange hue. This lesion exhibits an oral region predilection.Its clinical differential diagnosis includes verrucous leukoplakia, verrucous carcinoma, squamous papilloma, verruca vulgaris, condyloma accuminatum, squamous cell carcinoma, and fibroepithelial polyp. Case Report: This report presents a case of VX of the ventral surface of the tongue afflicting a 33-year-old otherwise healthy male. Conclusion: This case report can be valuable as a consequence of VX rarity and the similarity of its clinical features to papillary lesions. A biopsy is required for its definite diagnosis particularly when it occurs at sites with a high-risk of squamous cell carcinoma development, such as the lateral border and ventral surface of the tongue.
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- 2021
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19. Verruköser exophytischer Tumor der Glans penis
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Aebischer, Valentin and Forchhammer, Stephan
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- 2023
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20. Verruciform Genital-Associated (Vegas) Xanthoma: report of a patient with verruciform xanthoma of the scrotum and literature review
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Beutler, Bryce D and Cohen, Philip R
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anogenital ,foam cells ,penis ,scrotum ,verruciform ,verruciform xanthoma ,vulva ,xanthoma - Abstract
Background: Verruciform xanthoma is a benign verrucous lesion characterized by epithelial acanthosis and lipid-laden foamy histiocytes in the connective tissue papillae. It typically presents as a papillomatous, polypoid, or sessile lesion. Verruciform xanthoma is most commonly observed within the oral cavity. However, albeit less frequently, it develops on the penis, scrotum, or vulva.Purpose: We describe the clinical and pathologic findings of a man who developed a verruciform xanthoma on his scrotum. We also summarize the associated conditions, the differential diagnosis, the postulated pathogenesis, and the treatment options for this tumor.Materials and methods: The features of a man with a scrotal verruciform xanthoma are presented. Using PubMed, the following terms were searched and relevant citations assessed: anogenital, foam cells, penis, scrotum, verruciform, verruciform xanthoma, vulva, and xanthoma. In addition, the literature on verruciform xanthoma is reviewed.Results: Our patient developed an asymptomatic, exophytic, red filiform papule on his scrotum. A shave biopsy, attempting to remove the entire lesion, was performed. Based on correlation of the clinical presentation and histopathologic findings, a diagnosis of verruciform xanthoma was established. The patient applied mupirocin 2% ointment to the biopsy site, which subsequently healed without complication or recurrence.Conclusion: Verruciform xanthoma is a benign tumor commonly located within the oral cavity and characterized by the development of a small verrucous, papillomatous, polypoid, or sessile growth. Extraoral sites of verruciform xanthoma often include the penis, scrotum, or vulva; we introduce the term 'Vegas' (Verruciform Genital-Associated) xanthoma for these lesions. The lesions are often mistaken for viral warts or malignancies. Although the mechanism of pathogenesis is unknown, verruciform xanthoma may have a multifactorial etiology involving inflammation, local immunosuppression, and/or metabolic dysfunction. It has also been postulated that verruciform xanthoma is a secondary reaction to trauma-induced epithelial damage or degeneration. A biopsy for histopathologic examination is required to diagnose verruciform xanthoma. The treatment of verruciform xanthoma typically involves simple surgical excision.
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- 2015
21. Verruciform xanthoma of the vulva in the context of lichen sclerosus: A mimicker of HPV and p53-independent intraepithelial neoplasia
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Simon F. Roy, Jahg Wong, and Kurosh Rahimi
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Verruciform xanthoma ,Vulva ,VAAD ,DEVIL ,Lichensclerosus ,Vulvar acanthosis with altered differentiation ,Pathology ,RB1-214 - Abstract
A 67-year-old woman presented with a 2 x 1.5 cm white, asymptomatic verrucous plaque on the left labia minora. She was known for vulvar lichen sclerosus et atrophicus (LSA) for 1.5 years, treated with high-potency topical corticosteroids. A biopsy of the verrucous lesion demonstrated a small fragment of parakeratotic vulvar epithelium with papillomatosis and moderate basal atypia, spongiosis and mitoses. Neutrophils were present, forming microabscesses in the stratum corneum. The granular layer was lost in those acanthotic areas. The differential diagnosis included vulvar verruciform lichen simplex chronicus, verrucous carcinoma, vulvar acanthosis with altered differentiation, differentiated exophytic vulvar intraepithelial neoplasia or verruciform xanthoma. We demonstrate how accurately diagnosing verruciform xanthoma in the context of inflammatory dermatoses of genital sites is crucial to avoid overtreating as a preneoplastic mimicker lesion.
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- 2021
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22. Verruciform xanthoma of the tongue
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Ming-Jane Lang, Julia Yu-Fong Chang, Chun-Pin Chiang, and Ying-Tai Jin
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Verruciform xanthoma ,Tongue ,Etiology ,Dentistry ,RK1-715 - Published
- 2022
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23. Verruciform genital-associated xanthoma with acantholysis: Report of a rare case
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Sara Moradi, MD, Jeffrey Morgenstern, MD, and Torsten Ehrig, MD
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acantholysis ,histopathology ,Vegas ,verruciform genital-associated xanthoma ,verruciform xanthoma ,Dermatology ,RL1-803 - Published
- 2020
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24. Multiple oral verruciform xanthomas: A rare entity
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Jayati Shailesh Dave, Sunanda Arun Mahajan, Atul M Dongre, and Meghana Rane
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cryotherapy ,oral ,verruciform xanthoma ,Dermatology ,RL1-803 - Abstract
Verruciform xanthoma (VX) is an uncommon benign lesion that can affect oral, genital mucosa, and rarely skin. The characteristic foam cells seen in papillary dermis are a hallmark for diagnosing this entity. A 42-year-old male, tobacco-chewer presented with asymptomatic white-circular plaques on the bilateral buccal mucosa and yellow papules on retromolar area which on histopathological evaluation showed parakeratotic epithelium with surface and deep invagination of columns of parakeratosis throughout the hyperplastic epidermis, few neutrophils in upper spinous layers, and uniform elongation of rete ridges. The rete ridges showed numerous lipid-laden CD 68-positive foam cells. Punch excision coupled with cryotherapy was done, which resulted in the complete resolution of lesions. We publish this uncommon benign entity for increased awareness among physicians to consider it as a differential of verrucous lesion in the mucosa. Our patient had two different morphology of lesions, both suggestive of VX with characteristic foam cells on histopathology.
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- 2020
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25. Radicular cyst with features mimicking a verruciform xanthoma.
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Wu, Yu-Hsueh, Wu, Yang-Che, Sun, Andy, and Chiang, Chun-Pin
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RADICULAR cyst - Published
- 2022
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26. Oral verruciform xanthoma in chronic graft-versus-host disease patients.
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Bar, Ori, Elad, Sharon, Avni, Batia, Abu-Tair, Jawad, Zaharia, Bianca, Hanut, Aiham, and Zadik, Yehuda
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CHRONICALLY ill , *GRAFT versus host disease , *HARD palate , *HEMATOPOIETIC stem cell transplantation - Abstract
Background: Verruciform xanthoma (VX) is an uncommon benign epithelial lesion which mainly appears in inflamed oral epithelium. In this study, our aim was to present new cases of oral VX (OVX) in chronic graft-versus-host disease (cGVHD) and review the literature.Methods: We conducted a retrospective chart review of cGVHD patients (2012-2019) to reveal cases of OVX. The demographics, medical background, clinical presentation, treatment provided, and follow-up were obtained. Additionally, Medline was searched using the terms "graft-versus-host disease," "verruciform xanthoma," and "oral." Of the articles, the above-mentioned demographic and clinical features were retrieved.Results: The patient pool included 133 oral cGVHD patients. Three cGVHD patients (males, aged 15-49 years, post-hematologic malignancy) were diagnosed with OVX. All patients had oral mucosal lichenoid lesions, but not in close proximity to the VX lesion. Medline searches revealed 9 cases of OVX in cGVHD patients reported in the literature. Eleven of the 12 patients had oral mucosal lichenoid lesions. Four patients had multiple OVX lesions. All lesions were asymptomatic. Six patients had lesions in the masticatory mucosa (hard palate and gingiva) and 4 patients had lesions in the buccal mucosa.Conclusions: To the best of our knowledge, this is the largest published OVX in cGVHD series, including 12 patients. It appears that despite the higher prevalence in cGVHD patients relative to the general population, OVXs do not necessarily develop in sites with lichenoid lesions. It is advised that clinicians be familiar with the clinical and histological features in order to consider OVX in the differential diagnosis of oral lesions in cGVHD patients. [ABSTRACT FROM AUTHOR]- Published
- 2021
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27. Verruciform Xanthoma of the Ventral Surface of the Tongue: A Rare Case Report and Literature Review.
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Atarbashi-Moghadam, Saede, Lotfi, Ali, Kabiri, Farnoush, and Sijanivandi, Soran
- Subjects
- *
SQUAMOUS cell carcinoma , *LITERATURE reviews , *PAPILLOMA , *TONGUE diseases , *DIAGNOSIS , *MACROPHAGES , *DIFFERENTIAL diagnosis - Abstract
Introduction: Verruciform xanthoma (VX) is an uncommon benign lesion with the subepithelial accumulation of foamy histiocytes and superficial papillary proliferations with a bright orange hue. This lesion exhibits an oral region predilection. Its clinical differential diagnosis includes verrucous leukoplakia, verrucous carcinoma, squamous papilloma, verruca vulgaris, condyloma accuminatum, squamous cell carcinoma, and fibroepithelial polyp. Case Report: This report presents a case of VX of the ventral surface of the tongue afflicting a 33-year-old otherwise healthy male. Conclusion: This case report can be valuable as a consequence of VX rarity and the similarity of its clinical features to papillary lesions. A biopsy is required for its definite diagnosis particularly when it occurs at sites with a high-risk of squamous cell carcinoma development, such as the lateral border and ventral surface of the tongue. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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28. Three cases of verruciform xanthoma occurs gingiva
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歯肉 ,反応性変化 ,reactive changes ,benign tumor ,良性腫瘍 ,疣贅型黄色腫 ,verruciform xanthoma ,gingiva - Published
- 2023
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29. Rare case of large verrucous xanthoma of oral cavity managed with nasolabial flap and review of literature
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T. Balasundaram, P.K. Chattopadhyay, Ajay P. Desai, Ravinder Singh Semi, and K. Kamalpathey
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Verruciform xanthoma ,Gingiva ,Alveolar mucosa ,Nasolabial flap ,Surgery ,RD1-811 - Abstract
Verruciform Xanthoma (VX) is an rare benign mucocutaneous condition that occurs predominantly in the oral cavity which occasionally affects skin and genitals. It appears as a papule or single plaque showing a verrucous or papillomatous structure, with variable color from reddish pink to gray. In majority of oral cases, it affects gingiva and alveolar mucosa being a solitary lesion. It is often associated with pre-existing epithelial and/or inflammatory disorder and is characterized histopathologically by papillary epithelial hyperplasia and the presence of foamy macrophages in connective tissue papillae. We report a rare case of widespread verrucous xanthoma of gingiva and alveolar mucosa which was managed by wide local excision and defect was reconstructed using nasolabial flap.
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- 2020
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30. Genital verruciform xanthoma: lessons from a contemporary multi‐institutional series.
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Wang, Grace, Mochel, Mark C, Randall, M Barry, Gandhi, Jatin S, Udager, Aaron M, Chan, May P, Patel, Rajiv M, Amin, Mahul B, Osunkoya, Adeboye O, and Smith, Steven C
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ORAL mucosa , *SQUAMOUS cell carcinoma , *PERINEUM , *SCROTUM - Abstract
Aims: Verruciform xanthoma (VX) is an uncommon lesion, seen in the oral mucosa and rarely occurring at cutaneous genital sites. Reports of exceptional VX presentations dominate the literature; herein, we assess the clinical and histological features of a cohort of routine, consecutive cases. Methods and results: Clinicopathological features of genital VXs from four academic centres were reviewed. A cohort of 25 lesions from 24 patients (22 male, two female; median age = 62 years), occurred on the scrotum (84%), penis (8%) and perineum/vulva (8%). VX was never suspected clinically; considerations ranged from fibroepithelial polyps to squamous cell carcinoma. Classic diagnostic criteria were present at least focally in each lesion, including verrucous architecture, prominent wedge‐shaped parakeratosis extending between exophytic epidermal projections and neutrophils in the stratum corneum. Xanthomatous cells were present in all cases, but scattered to rare in 24%. Conclusions: Consecutive genital VXs reliably exhibited classic histopathological features, although the essential finding of xanthomatous cells may be scarce. Our comparison to meta‐analyses of published cases found relatively fewer penile and vulvar examples. Additionally, the median age was older than in published series, which have emphasised syndromic associations. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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31. Verruciform Xanthoma in the Marginal Gingiva: A Clinical Case Report.
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Khuntia, Prachi, Nayak, Rashmita, Mohanty, Neeta, Satpathy, Anurag, Das, Abhaya Chandra, Panda, Saurav, and Das, Sharmistha
- Subjects
GINGIVA ,VIRUS diseases ,MUCOUS membranes ,MACROPHAGES - Abstract
Verruciform xanthoma can be described as a rare, benign lesion. It can be classified as a papillary, asymptomatic or sessile. it can be well-demarcated from the adjacent tissue and can be seen frequently in the alveolar mucosa and gingiva. The salient histopathological feature is the abundance of foam cells (xanthoma cells) along with macrophages present in the soft papillary tissue. 1 The exact etiopathogenesis is still unknown, but the causative agents can be local factors like viral infections or trauma that have been suggested by hypothesis. Therefore this case report aims to present a case of verruciform xanthoma located in the marginal gingiva (lingual aspect) and describe the clinical features and histopathological aspects. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
32. Oral Verruciform Xanthoma: A Series of 212 Cases and Review of the Literature.
- Author
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Belknap, Austin N., Islam, Mohammed N., Bhattacharyya, Indraneel, Cohen, Donald M., and Fitzpatrick, Sarah G.
- Abstract
Verruciform xanthoma (VX) of the oral cavity is an uncommon, reactive lesion of unknown etiology. In this study, we present a large series of VX with analysis of demographics, clinical appearance, histologic presentation and extensive review of literature. To the best of our knowledge, this is the largest series of oral VX reported to date. Following IRB approval, all cases diagnosed as VX found in the archives of the University of Florida Oral Pathology Biopsy Service (1994–2018) were included. Patient age, gender, location, clinical appearance, clinical impression, and duration of each lesion was collected. A total of 212 cases were included in our database with a mean age of 61 years (range of 9–94), and a female: male ratio of 1.06:1. The most common location in descending order was the gingiva (n = 110, 51.2%), followed by palate (n = 41, 19.3%), buccal mucosa (n = 18, 8.5%), tongue (n = 20, 9.4%), vestibule (n = 13, 6.1%), lip (n = 4, 1.9%), floor of mouth (n = 3, 1.4%), and unspecified (n = 1, 0.5%). The lesions were most frequently pink in color, and most often described as bumpy, rough, verrucoid and/or papillary. Clinical impression in descending order was papillary (n = 67, 31.6%), not specified or unknown (n = 41, 19.3%), hyperkeratosis (n = 24, 11.3%), fibroma (n = 20, 9.4%), leukoplakia (n = 17, 8.0%), dysplastic lesion (n = 13, 6.1%), pyogenic granuloma (n = 7, 3.3%), granulomatous reaction (n = 5, 2.4%), lichen planus, VX (n = 4 each, 2.0%), pigmented, other lesions (n = 3 each, 1.4%), and salivary and periapical lesions (n = 2 each, 0.9%). Three of the lesions were recurrences. The demographics and clinical parameters of this case series were in concordance with that of previously published reports. In our series, only 4 cases were suspected as VX, demonstrating the lack of familiarity clinicians have with this lesion. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
33. Verruciform xanthoma accompanying a cystic growth: A case report.
- Author
-
Hara, Mariko, Kato, Yoichi, Kaku, Yo, and Tsujioka, Kaoru
- Subjects
- *
XANTHOMA , *ORAL mucosa , *DERMIS , *EPIDERMIS - Abstract
Verruciform xanthoma, an uncommon, benign lesion with characteristic histopathological features, usually develops on the oral mucosa or genital area. We present an unusual case of verruciform xanthoma observed on the inguinal skin of a 52‐year‐old healthy man along with an underlying cystic component. The superficial lesion was a pedunculated nodule with a fissured surface and an 18‐mm mound‐like pigmented tumor underneath it. The histopathologically deep lesion was continuously attached to the superficial lesion. It was composed of fistula or sinus‐like spaces and covered with acanthotic epithelium. The epidermis and upper dermis of both lesions showed identical histopathological findings: varying degrees of acanthosis, elongation of rete ridges, eosinophilic parakeratotic layer extending toward the dermis, and densely infiltrating foam cells confined to the papillary layer of the dermis. This finding of a cystic component in the deep dermis expands the histopathologic features of verruciform xanthoma. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
34. Verruciform Xanthoma of the Esophagus: Two Case Reports With Review of the Literature.
- Author
-
Noguchi, Hirotsugu, Kitazono, Ikumi, Hamada, Kazumasa, Tanaka, Takako, Tasaki, Takashi, Shirahama, Hiroshi, Yamamoto, Yoshimasa, and Tanimoto, Akihide
- Subjects
- *
ESOPHAGUS , *HELICOBACTER pylori infections , *XANTHOMA , *LITERATURE reviews , *ORAL mucosa - Abstract
Verruciform xanthoma is a rare benign verrucopapillary lesion that develops in the oral mucosa and genital skin. Its development in the esophagus is extremely rare, with only 5 reported cases. We present 2 cases of verruciform xanthoma of the esophagus. Case 1 involved a 91-year-old woman, who had hypertension and chronic gastritis with Helicobacter pylori infection, with a 12-year history of a 10-mm white-yellow elevated lesion on the esophagus, 35 cm from the incisor teeth. Case 2 involved a 70-year-old man with fundic gland polyp, hyperlipidemia, and lung cancer, who had a 10-mm whitish granular/verrucoid lesion on the esophagus, 28 cm from the incisor teeth. Microscopically, these lesions show verrucous and papillomatous epithelial hyperplasia with neutrophilic intraepithelial exocytosis. The histological hallmark is the presence of numerous foamy histiocytes infiltrating the elongated squamous epithelial papillae. Although its etiology is unknown, irritation or trauma caused by radiotherapy has been suggested. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
35. Verruciform xanthoma in recessive dystrophic epidermolysis bullosa and keratitis‐ichthyosis‐deafness syndrome: Report of two cases and a review of the literature.
- Author
-
Evan‐Browning, Eric, Rork, Jillian, O'Donnell, Patrick, Elaba, Zendee, Deng, April, and Wiss, Karen
- Subjects
- *
EPIDERMOLYSIS bullosa , *ICHTHYOSIS , *XANTHOMA , *LITERATURE reviews , *SQUAMOUS cell carcinoma , *SYNDROMES - Abstract
Verruciform xanthoma is a benign, wart‐like lesion that can clinically mimic squamous cell carcinoma. We describe two teenage patients with severe genodermatoses, recessive dystrophic epidermolysis bullosa (RDEB), and keratitis‐ichthyosis‐deafness (KID) syndrome, respectively, each found to have plaques suspicious for malignancy, later demonstrated on histopathologic examination to be verruciform xanthoma. We discuss the connection between these severe genodermatoses and the suspected pathophysiology of verruciform xanthoma. In addition, we highlight the importance of recognizing verruciform xanthoma as a clinical mimicker of squamous cell carcinoma, for which patients with RDEB and KID syndrome are at increased risk. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
36. Oral verruciform xanthoma and erythroplakia associated with chronic graft-versus-host disease: a rare case report and review of the literature
- Author
-
Giorgia Capocasale, Vera Panzarella, Pietro Tozzo, Rodolfo Mauceri, Vito Rodolico, Dorina Lauritano, and Giuseppina Campisi
- Subjects
Chronic graft versus-host-disease ,Verruciform xanthoma ,Oral potential malignant disorder ,Erythroplakia ,Medicine ,Biology (General) ,QH301-705.5 ,Science (General) ,Q1-390 - Abstract
Abstract Background Oral verruciform xanthoma is an uncommon benign lesion. Although oral verruciform xanthoma occurs in healthy individuals, it has been also reported in association with some inflammatory conditions. The aim of this study is to report a case of oral verruciform xanthoma associated with chronic graft-versus-host disease and to review the literature on this topic. Case presentation A 47-year-old Caucasian male presented to the Sector of Oral Medicine “V. Margiotta”, University Policlinic “P. Giaccone” of Palermo complaining of a mass on the gingiva. He first noticed the painless mass 1 year ago. He reported to have undergone allogenic hematopoietic stem cell transplantation 15 years ago for acute lymphoblastic leukaemia. Intraoral examination revealed a well-circumscribed, sessile yellowish and verrucous nodule upon canine, multiple yellowish and verrucous nodules on the hard palate, yellowish and verrucous nodules on left buccal mucosa. In addiction an area of white striae in a reticular pattern with erythema and ulceration was present on the dorsum of the tongue. This lesion was consistent with a known history of oral chronic graft versus host disease. Moreover, we observed a suspected area of oral erythroplakia yet on the dorsum of the tongue. In biopsy specimen of hard palate histopathological examination revealed a diagnosis of verrucous xanthoma of the oral cavity; in addiction in biopsy specimen of the dorsum of the tongue revealed the presence of erythroplakia with high grade dysplasia. Conclusion Verruciform xanthoma of the oral cavity associated with chronic graft-versus-host disease is a rare condition with a usually benign clinical course but malignant transformation has been described in association with oral potential malignant disorder (e.g. chronic graft versus host disease, erythroplakia). Very rare cases showed association with oral chronic graft versus-host-disease. To date, only eight cases were published in the world literature. Therefore it could be important follow up patients also for oral verruciform xanthoma onset.
- Published
- 2017
- Full Text
- View/download PDF
37. Verruciform Xanthoma of a Lower Lip Lesion: A New Case and Review of the Literature
- Author
-
Filiz Cebeci, Ayşegül Verim, Adnan Somay, and Emel Çalıkoğlu
- Subjects
Lip diseases ,Verruciform xanthoma ,Dermatology ,RL1-803 - Abstract
A non-smoking man in his seventh decade presented with a lesion he had had for about 5 years on the right external surface of the lip 1 mm from the vermilion border. On physical examination, a yellowish-coloured, non-tender, verrucous mass of 0.5 × 0.7 cm was observed. A histopathological examination of the first 3-mm punch biopsy was non-diagnostic. The histopathological evaluation of a second, 5-mm-deep punch biopsy made by a pathology expert in oral lesions revealed a diagnosis of verruciform xanthoma. The key to the diagnosis of verruciform xanthoma is to recognize xanthoma cells. However, these cells may be insufficient in number in small and superficial biopsy material and overlooked by a pathologist especially when lacking knowledge of this uncommon lesion. Verruciform xanthoma of the lower lip at the vermilion border is an extremely rare entity described in 5 cases worldwide to date. We aimed to bring verruciform xanthoma to readers’ attention for a differential diagnosis of lower lip diseases and to prevent overdiagnosis and overtreatment of this lesion unfamiliar to otorhinolaryngologists.
- Published
- 2017
- Full Text
- View/download PDF
38. Review of genodermatoses with characteristic histopathology and potential diagnostic delay.
- Author
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Ko, Christine J., Atzmony, Lihi, Lim, Young, McNiff, Jennifer M., Craiglow, Brittany G., Antaya, Richard J., and Choate, Keith A.
- Subjects
- *
SKIN diseases , *GENETIC disorders , *HISTOPATHOLOGY , *HUMAN genetics , *INFANTS - Abstract
Advances in human genetics have enabled discovery of new genes for inherited skin diseases and cutaneous malformations as well as refined categorization of genodermatoses. Careful phenotyping has been central to genetic discoveries, and it provides critical clues for clinical diagnoses, particularly when the skin disorder is not congenital. This article will review several lesser‐known genodermatoses that often present after infancy with recognizable histopathologic features. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
39. Verruciform Xanthoma of the Oral Mucosa: A Series of Eight Typical and Three Anomalous Cases.
- Author
-
Barrett, A. W., Boyapati, R. P., Bisase, B. S., Norris, P. M., Shelley, M. J., Collyer, J., Sneddon, K. J., and Gulati, A.
- Subjects
- *
ORAL mucosa , *XANTHOMA , *SQUAMOUS cell carcinoma - Abstract
In this series, there are 8 typical verruciform xanthomas of the oral mucosa and 3 anomalies, 1 polypoid, 1 florid, and 1 carcinomatous. All were characterized by infiltrates of CD68-positive xanthomatous histiocytes in the lamina propria. The 11 patients comprised 6 men and 5 women (mean age = 54.5 years, range = 40-69). Both keratinized and nonkeratinized sites were affected. A history of lichenoid inflammation was recorded in 5 patients. The polypoid xanthoma presented in a woman aged 54 years as a polyp of the labial commissure. The florid lesion affected the dorsum of the tongue of a man aged 54 years and at 20 mm was the largest of the 11 lesions, but the only one with candidal infection. The squamous cell carcinoma manifested as a papilloverrucous hyperkeratosis of the palatal gingiva in a man aged 69 years. The latter 2 (and 1 "typical" verruciform xanthoma) required re-excision, but none has since recurred. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
40. Non-HPV Papillary Lesions of the Oral Mucosa: Clinical and Histopathologic Features of Reactive and Neoplastic Conditions.
- Author
-
Mainville, Gisele N.
- Abstract
Excluding human papillomavirus (HPV)-driven conditions, oral papillary lesions consist of a variety of reactive and neoplastic conditions and, on occasion, can herald internal malignancy or be part of a syndrome. The objectives of this paper are to review the clinical and histopathological features of the most commonly encountered non-HPV papillary conditions of the oral mucosa. These include normal anatomic structures (retrocuspid papillae, lingual tonsils), reactive lesions (hairy tongue, inflammatory papillary hyperplasia), neoplastic lesions (giant cell fibroma), lesions of unknown pathogenesis (verruciform xanthoma, spongiotic gingival hyperplasia) and others associated with syndromes (for instance Cowden syndrome) or representing paraneoplastic conditions (malignant acanthosis nigricans). Common questions regarding differential diagnosis, management, and diagnostic pitfalls are addressed, stressing the importance of clinico-pathologic correlation and collaboration. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
41. Insight into verruciform xanthoma with oral submucous fibrosis: Case report and review of literature.
- Author
-
Gannepalli, Ashalata, Appala, Amruta, Reddy, Lavanya, and Babu, Dara Balaji
- Subjects
XANTHOMA ,ORAL mucosa ,FIBROSIS ,PAPILLOMA ,SQUAMOUS cell carcinoma - Abstract
Verruciform xanthoma (VX) is a rare benign mucocutaneous verrucopapillary lesion, which mainly involves masticatory mucosa and gingiva. Clinically, it presents as a solitary, sessile or pedunculated, white- or yellow-white-colored growth with a pebbled surface, hence often misdiagnosed as papilloma. The hallmark of histological diagnosis is the presence of foam cells or xanthoma cells confined to the connective tissue papillae. We present a case of VX on the maxillary gingiva in a 52-year-old male patient with oral submucous fibrosis (OSF) with a review on histopathology and concomitant oral lesions. The exact etiopathogenesis is not clearly delineated more so when it is associated with diverse local and systemic conditions. Its concomitant association with other conditions such as lichen planus, leukoplakia, oral squamous cell carcinoma and OSF is rare, with only three cases of VX associated with OSF reported earlier. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
42. Un xanthome verruciforme vulvaire
- Author
-
Françoise Plantier and Charly Liddell
- Subjects
0301 basic medicine ,Pathology ,medicine.medical_specialty ,integumentary system ,business.industry ,Papillary dermis ,Context (language use) ,medicine.disease ,Pathology and Forensic Medicine ,Vulva ,Squamous carcinoma ,Lesion ,stomatognathic diseases ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,medicine ,Epidermis ,medicine.symptom ,Parakeratosis ,business ,Verruciform xanthoma - Abstract
We report a case of a vulvar verruciform xanthoma. Verruciform xanthoma is a rare benign lesion that occurs most commonly on the oral and genital mucosa. Under the microscope, this lesion displays acanthotic papillary epidermis with parakeratosis that extends deep into the epithelium, elongated rete ridges and xanthomatous cells in the papillary dermis. Vulvar lesions almost always occur in a local pathological context (lichen planus or sclerosus). It is important to be aware of this entity as it can mimic squamous carcinoma.
- Published
- 2022
- Full Text
- View/download PDF
43. Wart on fire: A rare entity of verruciform xanthoma arising on a lower leg in a setting of chronic lymphedema
- Author
-
Simon F. Roy, Robert Prokopetz, MD, FRCPC, Yasmine Ayroud, MD, FRCPC, Laura Pickett, MD, and Ivan V. Litvinov, MD, PhD, FRCPC
- Subjects
leg ,lower extremity ,lymphedema ,parakeratosis ,trauma ,ulcer ,verruciform xanthoma ,Dermatology ,RL1-803 - Published
- 2017
- Full Text
- View/download PDF
44. An Asymptomatic Verrucous Nodule on the Scrotum: A Quiz
- Author
-
Yue-Tong Qian, Jia-Wei Liu, Wei Liu, and Dong-Lai Ma
- Subjects
verruciform xanthoma ,male genitelia ,scrotum ,Dermatology ,RL1-803 - Published
- 2019
- Full Text
- View/download PDF
45. Verruciform Xanthoma: An Unusual Lesion of Tongue- A Case Report and Review of Literature.
- Author
-
Rajalakshmi, G., Vinod, Sankar, Anjana, R., Mathews, Pramod P., and Rajan, Reeji
- Subjects
XANTHOMA ,LANGERHANS cells ,PHYSIOLOGICAL effects of tobacco - Abstract
Verruciform xanthoma (VX) is a rare entity and we could procure only very few publications in the literature. This innocuous lesion with a sessile or pedunculated base is normal, reddish in color but occasionally pale or hyperkeratotic with rough or pebbly surface; 75% of VX occurs in masticatory mucosa, gingiva, and palate and very few occurs in buccal mucosa, floor of the mouth, and rarely in the tongue. Our case on the tongue exhibited papillary or verrucous proliferation of squamous epithelium associated with hyperkeratosis and with copious foamy cells confined to lamina propria papillae. The hallmark of VX is the presence of vacuolated foam or xanthoma cells. The xanthoma cells have been shown to be cells of the monocyte/macrophage lineage. The exact etiopathogenesis of VX is not fully known, but various concepts have been postulated. Recurrence is unusual after surgical removal. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
46. Clinical, histological, and deep learning-based assessments and treatment of oral verruciform xanthoma: a case report
- Author
-
Lee Jae-Hong and Jeong Seong-Nyum
- Subjects
medicine.medical_specialty ,medicine.anatomical_structure ,medicine.diagnostic_test ,business.industry ,Biopsy ,Medicine ,Hard palate ,business ,medicine.disease ,Dermatology ,Verruciform xanthoma - Published
- 2021
- Full Text
- View/download PDF
47. Histological differential diagnosis of verruca vulgaris: A systematic review
- Author
-
Mustafa Alaziz and Noor Rafid Najim
- Subjects
Seborrheic keratosis ,medicine.medical_specialty ,business.industry ,Papillomatosis ,Epidermodysplasia verruciformis ,medicine.disease ,Dermatology ,medicine ,Confluent and reticulated papillomatosis ,medicine.symptom ,Differential diagnosis ,business ,Acanthosis nigricans ,Verruca Vulgaris ,Verruciform xanthoma - Abstract
The diagnosis of Verruca Vulgaris is usually clinically, but, in certain situations, confirmation of the diagnosis with biopsy is needed. Several dermatological conditions share microscopic features with Verruca Vulgaris; however, the combination of history, dermatological examination, and histological description would confirm the diagnosis. The purpose of this study is to describe pathological conditions that share histological characteristics with verruca Vulgaris. A systematic review of the literature was used in this study. The histological differential diagnosis of verruca Vulgaris was divided into two categories. First, dermatological conditions that characterized by the presence of vacuolated cells; these conditions are Bowen’s Disease and Epidermodysplasia Verruciformis. Second, dermatological conditions that show papillomatosis which includes Verrucous Epidermal Nevus, Hyperkeratotic Seborrheic keratosis, and Acanthosis Nigricans Verruciform xanthoma, Confluent and reticulated papillomatosis.
- Published
- 2021
- Full Text
- View/download PDF
48. Verruciform xanthoma in groin – A case report
- Author
-
Nirmala R. Gaikwad
- Subjects
medicine.medical_specialty ,Groin ,business.industry ,Mucocutaneous zone ,Hyperkeratosis ,Papillomatosis ,medicine.disease ,Dermatology ,Vulva ,body regions ,surgical procedures, operative ,medicine.anatomical_structure ,Scrotum ,medicine ,medicine.symptom ,Parakeratosis ,business ,human activities ,Verruciform xanthoma - Abstract
Verruciform xanthoma is a rare benign mucocutaneous lesion. Extra oral sites are also reported mainly on vulva, groin, penis and scrotum. Histopathologic diagnosis is diagnostic and confirmative. Histopathology shows subepithelial lipid laden foamy histiocytes associated with hyperkeratosis, parakeratosis, papillomatosis and elongation of rete ridges. Here we report a case of Verruciform xanthoma in groin. Keywords: Verruciform xanthoma, Groin, Foam cells.
- Published
- 2021
- Full Text
- View/download PDF
49. Carcinoma cuniculatum in maxillary gingiva mimicking verruciform xanthoma: a case report
- Author
-
Chen Jiang, Yanhua Yang, Siqi Xu, and Dongmei Jia
- Subjects
Cancer Research ,medicine.medical_specialty ,business.industry ,squamous cell carcinoma (SCC) ,maxillary gingiva ,medicine.disease ,Dermatology ,stomatognathic diseases ,Carcinoma cuniculatum (CC) ,Oncology ,medicine ,Carcinoma ,case report ,Radiology, Nuclear Medicine and imaging ,business ,Maxillary gingiva ,verruciform xanthoma ,Verruciform xanthoma - Abstract
Carcinoma cuniculatum (CC) is a rare and well-differentiated clinicopathological variant of squamous cell carcinoma (SCC) that is not common in head and neck. It is defined histologically by the infiltrative pattern of a deep, broad, and complex proliferation of stratified squamous epithelium with keratin cores and keratin-filled crypts. It has a propensity for local invasion and rare metastasis. This case report describes a 39-year-old man who was referred to our hospital with painful swelling in the right maxillary gingiva for 1 month and restriction of mouth opening for 1 week. Two biopsy examinations were negative for the diagnosis of malignancy, and the patient was misdiagnosed with verruciform xanthoma before an accurate diagnosis of CC. The biopsy reports were not in line with the imaging findings and clinical manifestations. Finally, he was diagnosed based on the combination of clinical manifestations and the pathological findings. Our case report provided a thorough clinical and histopathologic case of CC in maxillary gingiva, together with a brief review of the literature. In addition, we highlighted the difficulties in arriving at this uncommon diagnosis, and discussed the diagnosis of CC based on the combination of clinical manifestations and the pathological findings. To our knowledge, this is a very rare case of CC of the gingiva mimicking verruciform xanthoma.
- Published
- 2021
50. Oral verruciform xanthoma and erythroplakia associated with chronic graft-versus-host disease: a rare case report and review of the literature.
- Author
-
Capocasale, Giorgia, Panzarella, Vera, Tozzo, Pietro, Mauceri, Rodolfo, Rodolico, Vito, Lauritano, Dorina, and Campisi, Giuseppina
- Subjects
- *
ERYTHROPLAKIA , *GRAFT versus host disease , *INFLAMMATION , *ERYTHEMA - Abstract
Background: Oral verruciform xanthoma is an uncommon benign lesion. Although oral verruciform xanthoma occurs in healthy individuals, it has been also reported in association with some inflammatory conditions. The aim of this study is to report a case of oral verruciform xanthoma associated with chronic graft-versus-host disease and to review the literature on this topic. Case presentation: A 47-year-old Caucasian male presented to the Sector of Oral Medicine "V. Margiotta", University Policlinic "P. Giaccone" of Palermo complaining of a mass on the gingiva. He first noticed the painless mass 1 year ago. He reported to have undergone allogenic hematopoietic stem cell transplantation 15 years ago for acute lymphoblastic leukaemia. Intraoral examination revealed a well-circumscribed, sessile yellowish and verrucous nodule upon canine, multiple yellowish and verrucous nodules on the hard palate, yellowish and verrucous nodules on left buccal mucosa. In addiction an area of white striae in a reticular pattern with erythema and ulceration was present on the dorsum of the tongue. This lesion was consistent with a known history of oral chronic graft versus host disease. Moreover, we observed a suspected area of oral erythroplakia yet on the dorsum of the tongue. In biopsy specimen of hard palate histopathological examination revealed a diagnosis of verrucous xanthoma of the oral cavity; in addiction in biopsy specimen of the dorsum of the tongue revealed the presence of erythroplakia with high grade dysplasia. Conclusion: Verruciform xanthoma of the oral cavity associated with chronic graft-versus-host disease is a rare condition with a usually benign clinical course but malignant transformation has been described in association with oral potential malignant disorder (e.g. chronic graft versus host disease, erythroplakia). Very rare cases showed association with oral chronic graft versus-host-disease. To date, only eight cases were published in the world literature. Therefore it could be important follow up patients also for oral verruciform xanthoma onset. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
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