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2. Sodium intake and urinary losses in children on dialysis: a European multicenter prospective study

Author

Paglialonga, Fabio, Shroff, Rukshana, Zagozdzon, Ilona, Bakkaloglu, Sevcan A., Zaloszyc, Ariane, Jankauskiene, Augustina, Gual, Alejandro Cruz, Consolo, Silvia, Grassi, Maria Rosa, McAlister, Louise, Skibiak, Aleksandra, Yazicioglu, Burcu, Puccio, Giuseppe, Edefonti, Alberto, Ariceta, Gema, Aufricht, Christoph, Holtta, Tuula, Klaus, Guenter, Ranchin, Bruno, Schmitt, Claus Peter, Snauwaert, Evelien, Stefanidis, Costantinos, Walle, Johan Vande, Stabouli, Stella, Verrina, Enrico, Vidal, Enrico, Vondrak, Karel, and Zurowska, Alexandra

Published
2023
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4. Vaccines and nephrotic syndrome: efficacy and safety

Author

Angeletti, Andrea, Lugani, Francesca, La Porta, Edoardo, Verrina, Enrico, Caridi, Gianluca, and Ghiggeri, Gian Marco

Subjects
Drugs -- Adverse and side effects, Nephrotic syndrome -- Risk factors, Communicable diseases in children -- Prevention, Vaccines -- Complications and side effects, Pediatric research, Health
Abstract

Vaccines represent the most important medical evolution in the last two centuries allowing prevention and formally eradication of a wide number of infectious diseases. Safety and effectiveness are main issues that still require an open discussion. A few clinical reports described a critical temporal relationship between vaccination and acute nephrotic syndrome, indirectly suggesting an association. For this review, the literature was reviewed to identify articles reporting associations of nephrotic syndrome with vaccines against a vast array of infectious diseases (including bacteria, virus and Sars-Cov-2). As specific aims, we evaluated effectiveness and safety in terms of occurrence of either 'de novo' nephrotic syndrome in health subjects or 'relapse' in those already affected by the disease. In total, 377 articles were found; 166 duplicates and 71 non-full text, animal studies or non-English language were removed. After excluding another 50 articles not containing relevant data on generic side effects or on relapses or new onset nephrotic syndrome, 90 articles met the search criteria. Overall, studies reported the effect of vaccines in 1015 patients, plus 4 nationwide epidemiologic investigations. Limited experience on vaccination of NS patients with measles, mumps, and rubella live attenuated vaccines does not allow any definitive conclusion on their safeness. VZV has been administered more frequently without side effects. Vaccines utilizing virus inactivated, recombinant, and toxoid can be utilized without risks in NS. Vaccines for influenza reduce the risk of infections during the pandemic and are associated with reduced risk of relapse of NS typically induced by the infection. Vaccines for SARS-CoV-2 (all kinds) offer a concrete approach to reduce the pandemic. 'De novo' NS or recurrence are very rare and respond to common therapies., Author(s): Andrea Angeletti [sup.1] , Francesca Lugani [sup.1] , Edoardo La Porta [sup.1] , Enrico Verrina [sup.1] , Gianluca Caridi [sup.1] , Gian Marco Ghiggeri [sup.1] Author Affiliations: (1) grid.419504.d, [...]

Published
2023
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5. Metabolic Acidosis Is Associated With an Accelerated Decline of Allograft Function in Pediatric Kidney Transplantation

Author

Ariceta, Gema, Awan, Atif, Bakkaloğlu, Sevcan, Bonthuis, Marjolein, Robroeks, Charlotte Bootsma, Bouts, Antonia, Christian, Martin, Cornelissen, Marlies, Duzova, Ali, Esfandiar, Nasrin, Ghio, Luciana, Grenda, Ryszard, Guzzo, Isabella, Goni, Maria Herrero, Hogan, Julien, Hongsawong, Nattaphorn, Kanzelmeyer, Nele, Bayazit, Aysun Karabay, Aksoy, Gülşah Kaya, Knops, Noel, Kamphuis, Linda Koster, Erez, Daniella Levy, Lopez-Baez, Victor, Madrid, Alvaro, Marks, Stephen, Melk, Anette, Murer, Luisa, Pape, Lars, Peruzzi, Licia, Petrosyan, Edita, Preka, Evgenia, Printza, Nikoleta, Rachisan, Andreea Liana, Raes, Ann, Shenoy, Mohan, Soylemezoglu, Oguz, Strologo, Luca Dello, Teixeira, Ana, Topaloglu, Rezan, Weitz, Markus, Zieg, Jakub, Zlatanova, Galia, Patry, Christian, Harambat, Jerome, Ağbaş, Ayşe, Askiti, Varvara, Avramescu, Marina, Bacchetta, Justine, Bakkaloglu, Sevcan, Bontuis, Marjolein, Booth, Caroline, Dehoux, Laurene, Dizazzo, Giacomo, Drozdz, Dorota, Dursun, Ismail, Gessner, Michaela, Groothoff, Jaap, Guido, Giuliana, Klaus, Guenter, Koster-Kamphuis, Linda, Lalayiannis, Alexander, Leifheit-Nestler, Maren, Manish, Sinha, Matteucci, Chiara, Oh, Jun, Ozkaya, Ozan, Pietrement, Christine, Prytula, Agnieszka, Reusz, George, Schaefer, Franz, Schmitt, Claus Peter, Schön, Anne, Sever, Fatma Lale, Stabouli, Stella, Döven, Serra Sürmeli, Tondel, Camilla, Verrina, Enrico, Vidal, Enrico, Wallace, Dean, Arslan, Zainab, Bald, M., Fehrenbach, H., Haffner, D., Hansen, M., Hempel, C., John, U., Klaus, G., König, J., Lange-Sperandio, B., Müller, D., Oh, J., Pape, L., Pohl, M., Sauerstein, K., Schalk, G., Staude, H., Strotmann, P., Weber, L.T., Weitz, M., Berta, L., Heindl-Rusai, K., Shroff, Rukshana, van Gremberghe, Ineke, Krupka, Kai, Benetti, Elisa, Büyükkaragöz, Bahar, Kranz, Birgitta, Nalçacıoğlu, Hülya, Sellier-Leclerc, Anne-Laure, and Tönshoff, Burkhard

Published
2024
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6. Best Practice of Peritoneal Dialysis-Associated Gram-Negative Peritonitis in Children: Insights From the International Pediatric Peritoneal Dialysis Network Registry

Author

Borzych-Dużałka, Dagmara, Same, Rebeca, Neu, Alicia, Yap, Hui Kim, Verrina, Enrico, Bakkaloglu, Sevcan A., Cano, Francisco, Patel, Hiren, Szczepańska, Maria, Obrycki, Łukasz, Spizzirri, Ana Paula, Sartz, Lisa, Vondrak, Karel, Rebori, Anabella, Milosevski-Lomic, Gordana, Chan, Eugene Yu-hin, Basu, Biswanath, Pezo, Andrea Lazcano, Zaloszyc, Ariane, Chadha, Vimal, Schaefer, Franz, and Warady, Bradley A.

Published
2024
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7. A critical view on autoantibodies in lupus nephritis: Concrete knowledge based on evidence

Author

Bruschi, Maurizio, Angeletti, Andrea, Prunotto, Marco, Meroni, Pier Luigi, Ghiggeri, Gian Marco, Moroni, Gabriella, Sinico, Renato Alberto, Franceschini, Franco, Fredi, Micaela, Vaglio, Augusto, Cavalli, Andrea, Scapozza, Leonardo, Patel, Jigar J., Tan, John C., Lo, Ken C., Cavagna, Lorenzo, Petretto, Andrea, Pratesi, Federico, Migliorini, Paola, Locatelli, Francesco, Pazzola, Giulia, Pesce, Giampaola, Giannese, Domenico, Manfredi, Angelo, Ramirez, Giuseppe A., Esposito, Pasquale, Murdaca, Giuseppe, Negrini, Simone, Bui, Federica, Trezzi, Barbara, Emmi, Giacomo, Cavazzana, Ilaria, Binda, Valentina, Fenaroli, Paride, Pisan, Isabella, Montecucco, Carlomaurizio, Santoro, Domenico, Scolari, Francesco, Mescia, Federica, Volpi, Stefano, Mosca, Marta, Tincani, Angela, Ravelli, Angelo, Murtas, Corrado, Candiano, Giovanni, Caridi, Gianluca, La Porta, Edoardo, and Verrina, Enrico

Published
2024
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8. MicroRaman spectroscopy detects the presence of microplastics in human urine and kidney tissue

Author

Massardo, Sara, Verzola, Daniela, Alberti, Stefano, Caboni, Claudia, Santostefano, Matteo, Eugenio Verrina, Enrico, Angeletti, Andrea, Lugani, Francesca, Ghiggeri, Gian Marco, Bruschi, Maurizio, Candiano, Giovanni, Rumeo, Noemi, Gentile, Micaela, Cravedi, Paolo, La Maestra, Sebastiano, Zaza, Gianluigi, Stallone, Giovanni, Esposito, Pasquale, Viazzi, Francesca, Mancianti, Nicoletta, La Porta, Edoardo, and Artini, Cristina

Published
2024
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9. Adequacy of Dialysis

Author

Verrina, Enrico Eugenio, Mammen, Cherry, Emma, Francesco, editor, Goldstein, Stuart L., editor, Bagga, Arvind, editor, Bates, Carlton M., editor, and Shroff, Rukshana, editor

Published
2022
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10. Safety and efficacy of cinacalcet in children below 3 years of age on maintenance dialysis

Author

Bernardor, Julie, primary, Flammier, Sacha, additional, Zagozdzon, Ilona, additional, Lalayiannis, Alexander D., additional, Koster-Kamphuis, Linda, additional, Verrina, Enrico, additional, Dorresteijn, Eiske, additional, Guzzo, Isabella, additional, Haffner, Dieter, additional, Shroff, Rukshana, additional, Schmitt, Claus P., additional, and Bacchetta, Justine, additional

Published
2024
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14. Proteomic Profiling of Cerebrospinal Fluid and Its Extracellular Vesicles from Extraventricular Drainage in Pediatric Pilocytic Astrocytoma, towards Precision Oncology

Author

Spinelli, Sonia, primary, Kajana, Xhuliana, additional, Garbarino, Andrea, additional, Bartolucci, Martina, additional, Petretto, Andrea, additional, Pavanello, Marco, additional, Verrina, Enrico, additional, Candiano, Giovanni, additional, Panfoli, Isabella, additional, and Bruschi, Maurizio, additional

Published
2024
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15. Best practice of PD-associated gram-negative peritonitis in children: Insights from the IPPN Registry.

Author

Borzych-Dużałka, Dagmara, primary, Same, Rebeca, additional, Neu, Alicia, additional, Yap, Hui Kim, additional, Verrina, Enrico, additional, Bakkaloglu, Sevcan A., additional, Cano, Francisco, additional, Patel, Hiren, additional, Szczepańska, Maria, additional, Obrycki, Łukasz, additional, Spizzirri, Ana Paula, additional, Sartz, Lisa, additional, Vondrak, Karel, additional, Rebori, Anabella, additional, Milosevski-Lomic, Gordana, additional, Chan, Eugene Yu-hin, additional, Basu, Biswanath, additional, Pezo, Andrea Lazcano, additional, Zaloszyc, Ariane, additional, Chadha, Vimal, additional, Schaefer, Franz, additional, and Warady, Bradley A., additional

Published
2024
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16. Ten-year trends in epidemiology and outcomes of pediatric kidney replacement therapy in Europe: data from the ESPN/ERA-EDTA Registry

Author

Bonthuis, Marjolein, Vidal, Enrico, Bjerre, Anna, Aydoğ, Özlem, Baiko, Sergey, Garneata, Liliana, Guzzo, Isabella, Heaf, James G., Jahnukainen, Timo, Lilien, Marc, Mallett, Tamara, Mirescu, Gabriel, Mochanova, Elena A., Nüsken, Eva, Rascher, Katherine, Roussinov, Dimitar, Szczepanska, Maria, Tsimaratos, Michel, Varvara, Askiti, Verrina, Enrico, Veselinović, Bojana, Jager, Kitty J., and Harambat, Jérôme

Published
2021
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22. Resident foreign patients receive adequate dialysis but fewer preemptive transplantations: data from the Italian pediatric dialysis registry

Author

Paglialonga, Fabio, Consolo, Silvia, Vidal, Enrico, Parolin, Mattia, Minale, Bruno, Giordano, Mario, Guzzo, Isabella, Benevenuta, Chiara, Roperto, Rosa, Corrado, Ciro, Mencarelli, Francesca, Chimenz, Roberto, Ratsch, Ilse-Maria, Pieri, Giovanni, Montini, Giovanni, Edefonti, Alberto, and Verrina, Enrico

Subjects
Kidneys -- Transplantation, Health care disparities -- Statistics, Hemodialysis -- Statistics -- Demographic aspects, Pediatric research, Health
Abstract

Background Sociocultural issues play a key role in children needing kidney replacement therapy (KRT). Methods Data of incident patients < 18 years treated with chronic dialysis or preemptive kidney transplantation (pTx) between 2007 and 2016 were retrospectively collected from the Italian Pediatric Dialysis Registry; KRT modality and outcome were compared between patients with at least one non-Italian parent ('resident foreign patients,' RFPs) and those from native parents ('domestic patients,' DPs) and between the quinquennium 2007-2011 (period 1) and 2012-2016 (period 2). Results We included 448 children (26.8% RFPs). The percentage of RFPs increased from 23 to 30.3% (p = 0.08) from periods 1 to 2. They were younger (6.7 vs. 9.4 years, p = 0.025) and less often treated with pTx (3.3 vs. 13.4%, p = 0.009) than DPs. The percentage of pTx increased from period 1 to 2 in RFPs only (8.4-18.6%, p = 0.006). Independent predictors of a lower probability of pTx were lower age, belonging to RFPs group, starting KRT in period 1 and focal segmental glomerulosclerosis or glomerulopathy as primary kidney disease. Peritoneal dialysis was the preferred dialysis modality in both groups. Age, primary kidney disease, and center size were independently associated with dialysis modality choice. Patient survival, waiting time to Tx, and dialysis modality survival were not different between the two groups. Conclusions The proportion of patients receiving KRT born from immigrant families increased in recent years in Italy. They were younger and less often treated with pTx than domestic patients. In case of dialysis, the outcome was not different between the two groups., Author(s): Fabio Paglialonga [sup.1] , Silvia Consolo [sup.1] , Enrico Vidal [sup.2] , Mattia Parolin [sup.3] , Bruno Minale [sup.4] , Mario Giordano [sup.5] , Isabella Guzzo [sup.6] , Chiara [...]

Published
2020
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25. Novel biomarkers and pathophysiology of membranous nephropathy: PLA2R and beyond.

Author

Murtas, Corrado, Bruschi, Maurizio, Spinelli, Sonia, Kajana, Xhuliana, Verrina, Enrico E, Angeletti, Andrea, Caridi, Gianluca, Candiano, Giovanni, Feriozzi, Sandro, Prunotto, Marco, and Ghiggeri, Gian Marco

Subjects
BIOMARKERS, PATHOLOGICAL physiology, AUTOIMMUNITY, G proteins, MASS spectrometry
Abstract

Research on membranous nephropathy truly exploded in the last 15 years. This happened because of the application of new techniques (laser capture microdissection, mass spectrometry, protein G immunoprecipitation, arrays) to the study of its pathogenesis. After the discovery of PLA2R as the major target antigen, many other antigens were identified and others are probably ongoing. Clinical and pathophysiology rebounds of new discoveries are relevant in terms of diagnosis and prognosis and it is time to make a first assessment of the innovative issues. In terms of classification, target antigens can be divided into: 'membrane antigens' and 'second wave' antigens. The first group consists of antigens constitutionally expressed on the podocyte membrane (as PLA2R) that may become a target of an autoimmune process because of perturbation of immune-tolerance. 'Second wave' antigens are antigens neo-expressed by the podocyte or by infiltrating cells after a stressing event: this allows the immune system to produce antibodies against them that intensify and maintain glomerular damage. With this abundance of target antigens it is not possible, at the moment, to test all antibodies at the bedside. In the absence of this possibility, the role of histological evaluation is still irreplaceable. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Microplastics and Kidneys: An Update on the Evidence for Deposition of Plastic Microparticles in Human Organs, Tissues and Fluids and Renal Toxicity Concern

Author

La Porta, Edoardo, primary, Exacoustos, Ottavia, additional, Lugani, Francesca, additional, Angeletti, Andrea, additional, Chiarenza, Decimo Silvio, additional, Bigatti, Carolina, additional, Spinelli, Sonia, additional, Kajana, Xhuliana, additional, Garbarino, Andrea, additional, Bruschi, Maurizio, additional, Candiano, Giovanni, additional, Caridi, Gianluca, additional, Mancianti, Nicoletta, additional, Calatroni, Marta, additional, Verzola, Daniela, additional, Esposito, Pasquale, additional, Viazzi, Francesca, additional, Verrina, Enrico, additional, and Ghiggeri, Gian Marco, additional

Published
2023
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29. Peritonitis

Author

Verrina, Enrico Eugenio, Warady, Bradley A, editor, Schaefer, Franz, editor, and Alexander, Steven R., editor

Published
2017
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30. Acute pancreatitis in children on chronic maintenance dialysis

Author

Vidal, Enrico, Alberici, Irene, and Verrina, Enrico

Subjects
Kidneys -- Transplantation, Chronic kidney failure -- Care and treatment -- Risk factors, Pancreatitis -- Risk factors, Pediatric research, Health
Abstract

Patients on dialysis are exposed to a series of factors that are known to be associated with risk of acute pancreatitis (AP), including medications, hyperparathyroidism, hypercalcemia, and hypertriglyceridemia; the role of the dialysis modality itself is still debated. Data regarding AP in children on chronic dialysis are scarce. Data from the Italian Registry of Pediatric Chronic Dialysis (IRPCD) confirm that children on dialysis have a significant increased relative risk (RR) for AP as compared with the general pediatric population (RR 60.4; 95% CI 3.2-214). Diagnosis of AP in patients on dialysis may be troublesome, because it can mimic other acute intraabdominal conditions and the role of serum pancreatic enzyme assays may be confounding. In this setting, instrumental imaging is mandatory. Conservative management such as fluid, bowel rest, and antibiotics is the mainstay of AP management, as necrotizing forms are rare. Mortality in the series of 12 patients from the IRPCD was high (25%), but deaths were not directly related to AP. Adult case series confirm that mortality among patients on dialysis who develop AP is highly variable (8-58%), but higher as compared to 10% mortality from AP in non-renal failure patients., Author(s): Enrico Vidal [sup.1] , Irene Alberici [sup.1] , Enrico Verrina [sup.2] Author Affiliations: (Aff1) 0000 0004 1760 2630, grid.411474.3, Pediatric Nephrology, Dialysis and Transplant Unit, Department for Woman's and [...]

Published
2019
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32. Infants with congenital nephrotic syndrome have comparable outcomes to infants with other renal diseases

Author

Dufek, Stephanie, Ylinen, Elisa, Trautmann, Agnes, Alpay, Harika, Ariceta, Gema, Aufricht, Christoph, Bacchetta, Justine, Bakkaloglu, Sevcan, Bayazit, Aysun, Caliskan, Salim, do Sameiro Faria, Maria, Dursun, Ismail, Ekim, Mesiha, Jankauskiene, Augustina, Klaus, Günter, Paglialonga, Fabio, Pasini, Andrea, Printza, Nikoleta, Conti, Valerie Said, Schmitt, Claus Peter, Stefanidis, Constantinos, Verrina, Enrico, Vidal, Enrico, Webb, Hazel, Zampetoglou, Argyroula, Edefonti, Alberto, Holtta, Tuula, Shroff, Rukshana, and On behalf of the ESPN Dialysis Working Group

Published
2019
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35. Case Report: Multisystem inflammatory syndrome in children with associated proximal tubular injury

Author

Orsi, Silvia Maria, primary, Pepino, Carlotta, additional, Rossoni, Lisa, additional, Serafino, Margherita, additional, Caorsi, Roberta, additional, Volpi, Stefano, additional, Palmieri, Serena, additional, Faragli, Alessandro, additional, Lugani, Francesca, additional, Bigatti, Carolina, additional, Ghiggeri, Gian Marco, additional, Verrina, Enrico Eugenio, additional, La Porta, Edoardo, additional, and Angeletti, Andrea, additional

Published
2023
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36. #6111 FIRST IDENTIFICATION AND CHARACTERIZATION OF MICROPLASTICS IN HUMAN KIDNEY AND URINE

Author

Exacoustos, Ottavia, primary, Artini, Cristina, additional, Massardo, Sara, additional, Caboni, Claudia, additional, Pastorino, Andrea, additional, Chiarenza, Silvio, additional, Zaza, Gianluigi, additional, Stallone, Giovanni, additional, Ghiggeri, Gian Marco, additional, Angeletti, Andrea, additional, Lugani, Francesca, additional, Verrina, Enrico Eugenio, additional, La Porta, Edoardo, additional, Esposito, Pasquale, additional, Viazzi, Francesca, additional, Verzola, Daniela, additional, Paccagnella, Chiara, additional, and Alberti, Stefano, additional

Published
2023
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37. #5502 PRO-INFLAMMATORY EFFECTS OF BISPHENOL A AND POLYETHYLENE MICROPLASTICS ON HUMAN RENAL TUBULAR CELLS

Author

Beltrame, Alice, primary, Rumeo, Noemi, additional, La Porta, Edoardo, additional, Verzola, Daniela, additional, Angeletti, Andrea, additional, Lugani, Francesca, additional, Gentile, Micaela, additional, Cravedi, Paolo, additional, Artini, Cristina, additional, Alberti, Stefano, additional, Caboni, Claudia, additional, Bertoli, Marika, additional, Chiarenza, Silvio, additional, Verrina, Enrico Eugenio, additional, Ghiggeri, Gian Marco, additional, Esposito, Pasquale, additional, and Viazzi, Francesca, additional

Published
2023
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38. #6225 MICROPLASTICS: FIRST EXTENDED PROTEOMIC ANALYSIS ON KIDNEY TUBULAR CELLS

Author

Cervello, Carla, primary, Bruschi, Maurizio, additional, Candiano, Giovanni, additional, Kajana, Xhuliana, additional, Garbarino, Andrea, additional, Rumeo, Noemi, additional, Petretto, Andrea, additional, Cravedi, Paolo, additional, Gentile, Micaela, additional, Angeletti, Andrea, additional, Lugani, Francesca, additional, Ghiggeri, Gian Marco, additional, Verrina, Enrico Eugenio, additional, Bigatti, Carolina, additional, Giordano, Paolo, additional, Esposito, Pasquale, additional, Viazzi, Francesca, additional, Verzola, Daniela, additional, and La Porta, Edoardo, additional

Published
2023
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39. Mechanisms Limiting Renal Tissue Protection and Repair in Glomerulonephritis

Author

Angeletti, Andrea, primary, Bruschi, Maurizio, additional, Kajana, Xuliana, additional, Spinelli, Sonia, additional, Verrina, Enrico, additional, Lugani, Francesca, additional, Caridi, Gialuca, additional, Murtas, Corrado, additional, Candiano, Giovanni, additional, Prunotto, Marco, additional, and Ghiggeri, Gian Marco, additional

Published
2023
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40. Peritoneal Dialysis in Children

Author

Verrina, Enrico, Schmitt, Claus Peter, Avner, Ellis D., editor, Harmon, William E., editor, Niaudet, Patrick, editor, Yoshikawa, Norishige, editor, Emma, Francesco, editor, and Goldstein, Stuart L., editor

Published
2016
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46. Anti-glutathione S-transferase theta 1 antibodies correlate with graft loss in non-sensitized pediatric kidney recipients

Author

Comoli, Patrizia, primary, Cioni, Michela, additional, Ray, Bryan, additional, Tagliamacco, Augusto, additional, Innocente, Annalisa, additional, Caridi, Gianluca, additional, Bruschi, Maurizio, additional, Hariharan, Jayasree, additional, Fontana, Iris, additional, Trivelli, Antonella, additional, Magnasco, Alberto, additional, Nocco, Angela, additional, Klersy, Catherine, additional, Muscianisi, Stella, additional, Ghiggeri, Gian Marco, additional, Cardillo, Massimo, additional, Verrina, Enrico, additional, Nocera, Arcangelo, additional, and Ginevri, Fabrizio, additional

Published
2022
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47. Evidence for charge-based mimicry in anti dsDNA antibody generation

Author

Bruschi, Maurizio, primary, Angeletti, Andrea, additional, Kajana, Xhuliana, additional, Moroni, Gabriella, additional, Sinico, Renato Alberto, additional, Fredi, Micaela, additional, Vaglio, Augusto, additional, Cavagna, Lorenzo, additional, Pratesi, Federico, additional, Migliorini, Paola, additional, Locatelli, Francesco, additional, Pazzola, Giulia, additional, Pesce, Giampaola, additional, Bagnasco, Marcello, additional, Manfredi, Angelo, additional, Ramirez, Giuseppe Alvise, additional, Esposito, Pasquale, additional, Negrini, Simone, additional, Bui, Federica, additional, Trezzi, Barbara, additional, Emmi, Giacomo, additional, Cavazzana, Ilaria, additional, Binda, Valentina, additional, Fenaroli, Paride, additional, Pisani, Isabella, additional, Montecucco, Carlomaurizio, additional, Santoro, Domenico, additional, Scolari, Francesco, additional, Volpi, Stefano, additional, Mosca, Marta, additional, Tincani, Angela, additional, Candiano, Giovanni, additional, Verrina, Enrico, additional, Franceschini, Franco, additional, Ravelli, Angelo, additional, Prunotto, Marco, additional, Meroni, Pier Luigi, additional, and Ghiggeri, Gian Marco, additional

Published
2022
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49. Lessons learned from the ESPN/ERA-EDTA Registry

Author

Harambat, Jerôme, Bonthuis, Marjolein, Groothoff, Jaap W., Schaefer, Franz, Tizard, E. Jane, Verrina, Enrico, van Stralen, Karlijn J., and Jager, Kitty J.

Subjects
Renal replacement therapy -- Research -- Health aspects, Chronic kidney failure -- Research -- Care and treatment, Health
Abstract

End-stage renal disease (ESRD) in children is a medically challenging condition. Due to its rarity and special features, methodologically sound collaborative studies are required. In 2007, a new European registry of pediatric renal replacement therapy (RRT), the ESPN/ERA-EDTA Registry, was launched. In recent years, the Registry has provided comprehensive data on incidence, prevalence, patient characteristics, RRT modalities, and mortality in pediatric ESRD, along with relevant insights into cardiovascular risk, anemia, nutrition and growth, transplantation outcomes, and rare diseases. In this review, we describe the study design and structure underlying the ESPN/ERA-EDTA Registry, summarize the major research findings from more than 20 publications, and discuss current limitations and the future challenges to overcome., Author(s): Jerôme Harambat[sup.1] , Marjolein Bonthuis[sup.2] , Jaap W. Groothoff[sup.3] , Franz Schaefer[sup.4] , E. Jane Tizard[sup.5] , Enrico Verrina[sup.6] , Karlijn J. van Stralen[sup.2] , Kitty J. Jager[sup.2] Author [...]

Published
2016
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