180 results on '"Verri C"'
Search Results
2. Baseline computed tomography screening and blood microRNA predict lung cancer risk and define adequate intervals in the BioMILD trial
- Author
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Pastorino U., Boeri M., Sestini S., Sabia F., Milanese G., Silva M., Suatoni P., Verri C., Cantarutti A., Sverzellati N., Corrao G., Marchiano A., Sozzi G., Pastorino, U, Boeri, M, Sestini, S, Sabia, F, Milanese, G, Silva, M, Suatoni, P, Verri, C, Cantarutti, A, Sverzellati, N, Corrao, G, Marchiano, A, and Sozzi, G
- Subjects
Lung Neoplasms ,microRNA ,risk profile ,Hematology ,MicroRNAs ,Oncology ,Risk Factors ,lung cancer screening ,Humans ,Mass Screening ,Prospective Studies ,low-dose computed tomography ,Tomography, X-Ray Computed ,Early Detection of Cancer - Abstract
Background: Large randomized trials have demonstrated that lung cancer (LC) screening with low-dose computed tomography (LDCT) reduces LC mortality in heavy smokers. We previously showed in the MILD screening trial that the combination of a prespecified circulating microRNA (miRNA) signature classifier (MSC) and LDCT improves the accuracy of LDCT alone. The primary aim of the prospective BioMILD study was to assess the additional value of the blood MSC assay at the time of baseline LDCT with the goal of personalizing LC screening intervals. Patients and methods: The study enrolled 4119 volunteers from January 2013 to March 2016, with a median follow-up of 5.3 years. Baseline LDCT and miRNAs stratified participants into four groups: CT−/MSC− (n = 2664; 64.7%); CT−/MSC+ (n = 800; 19.4%); CT+/MSC− (n = 446; 10.8%); and CT+/MSC+ (n = 209; 5.1%). As per the protocol, those in the CT−/MSC− and CT−/MSC+ groups were allocated to LDCT repeat at 3-year and 1-year intervals; CT+ participants were allocated for 1-year or earlier intervals on the basis of LDCT features independent of MSC results. Results: CT+ participants had a 15.8-fold higher 4-year LC incidence than CT− participants (95% confidence interval 10.34-24.05), and MSC+ participants had a 2.0-fold higher 4-year LC incidence than MSC− participants (95% confidence interval 1.40-2.90); there was no evidence that the MSC effect differed between CT+ and CT− participants. LC incidence at 4 years was 0.8% in CT−/MSC−, 1.1% in CT−/MSC+, 10.8% in CT+/MSC−, and 20.1% in CT+/MSC+ participants. LC mortality rates at 5 years in the four risk groups were 0.5 in CT−/MSC−, 1.5 in CT−/MSC+, 4.2 in CT+/MSC−, and 10.1 in CT+/MSC+. Conclusion: The combined use of LDCT and blood miRNAs at baseline predicts individual LC incidence and mortality, with a major effect of MSC for LDCT-positive individuals. These findings may have important implications in personalizing screening intervals.
- Published
- 2022
- Full Text
- View/download PDF
3. Whole genome sequencing of Shigella sonnei through PulseNet Latin America and Caribbean: advancing global surveillance of foodborne illnesses
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Baker, K.S., Campos, J., Pichel, M., Della Gaspera, A., Duarte-Martínez, F., Campos-Chacón, E., Bolaños-Acuña, H.M., Guzmán-Verri, C., Mather, A.E., Diaz Velasco, S., Zamudio Rojas, M.L., Forbester, J.L., Connor, T.R., Keddy, K.H., Smith, A.M., López de Delgado, E.A., Angiolillo, G., Cuaical, N., Fernández, J., Aguayo, C., Morales Aguilar, M., Valenzuela, C., Morales Medrano, A.J., Sirok, A., Weiler Gustafson, N., Diaz Guevara, P.L., Montaño, L.A., Perez, E., and Thomson, N.R.
- Published
- 2017
- Full Text
- View/download PDF
4. The Two-Component System BvrR/BvrS Essential for Brucella abortus Virulence Regulates the Expression of Outer Membrane Proteins with Counterparts in Members of the Rhizobiaceae
- Author
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Guzmán-Verri, C., Manterola, L., Sola-Landa, A., Parra, A., Cloeckaert, A., Garin, J., Moriyón, I., Moreno, E., and López-Goñi, I.
- Published
- 2002
5. Baseline computed tomography screening and blood microRNA predict lung cancer risk and define adequate intervals in the BioMILD trial
- Author
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Pastorino, U, Boeri, M, Sestini, S, Sabia, F, Milanese, G, Silva, M, Suatoni, P, Verri, C, Cantarutti, A, Sverzellati, N, Corrao, G, Marchiano, A, Sozzi, G, Pastorino U., Boeri M., Sestini S., Sabia F., Milanese G., Silva M., Suatoni P., Verri C., Cantarutti A., Sverzellati N., Corrao G., Marchiano A., Sozzi G., Pastorino, U, Boeri, M, Sestini, S, Sabia, F, Milanese, G, Silva, M, Suatoni, P, Verri, C, Cantarutti, A, Sverzellati, N, Corrao, G, Marchiano, A, Sozzi, G, Pastorino U., Boeri M., Sestini S., Sabia F., Milanese G., Silva M., Suatoni P., Verri C., Cantarutti A., Sverzellati N., Corrao G., Marchiano A., and Sozzi G.
- Abstract
Background: Large randomized trials have demonstrated that lung cancer (LC) screening with low-dose computed tomography (LDCT) reduces LC mortality in heavy smokers. We previously showed in the MILD screening trial that the combination of a prespecified circulating microRNA (miRNA) signature classifier (MSC) and LDCT improves the accuracy of LDCT alone. The primary aim of the prospective BioMILD study was to assess the additional value of the blood MSC assay at the time of baseline LDCT with the goal of personalizing LC screening intervals. Patients and methods: The study enrolled 4119 volunteers from January 2013 to March 2016, with a median follow-up of 5.3 years. Baseline LDCT and miRNAs stratified participants into four groups: CT−/MSC− (n = 2664; 64.7%); CT−/MSC+ (n = 800; 19.4%); CT+/MSC− (n = 446; 10.8%); and CT+/MSC+ (n = 209; 5.1%). As per the protocol, those in the CT−/MSC− and CT−/MSC+ groups were allocated to LDCT repeat at 3-year and 1-year intervals; CT+ participants were allocated for 1-year or earlier intervals on the basis of LDCT features independent of MSC results. Results: CT+ participants had a 15.8-fold higher 4-year LC incidence than CT− participants (95% confidence interval 10.34-24.05), and MSC+ participants had a 2.0-fold higher 4-year LC incidence than MSC− participants (95% confidence interval 1.40-2.90); there was no evidence that the MSC effect differed between CT+ and CT− participants. LC incidence at 4 years was 0.8% in CT−/MSC−, 1.1% in CT−/MSC+, 10.8% in CT+/MSC−, and 20.1% in CT+/MSC+ participants. LC mortality rates at 5 years in the four risk groups were 0.5 in CT−/MSC−, 1.5 in CT−/MSC+, 4.2 in CT+/MSC−, and 10.1 in CT+/MSC+. Conclusion: The combined use of LDCT and blood miRNAs at baseline predicts individual LC incidence and mortality, with a major effect of MSC for LDCT-positive individuals. These findings may have important implications in personalizing screening intervals.
- Published
- 2022
6. Introduzione
- Author
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Baris, T, Verri C, Baris, B, Verri, C, Baris, T, and Verri C
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Italy Resistence II world war - Abstract
The essay surves the historiographical on the structure of the Resistence of South Italy
- Published
- 2019
7. PL02.04 Blood MicroRNA and LDCT Reduce Unnecessary LDCT Repeats in Lung Cancer Screening: Results of Prospective BioMILD Trial
- Author
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Pastorino, U., primary, Boeri, M., additional, Sestini, S., additional, Sabia, F., additional, Silva, M., additional, Suatoni, P., additional, Verri, C., additional, Cantarutti, A., additional, Sverzellati, N., additional, Corrao, G., additional, Marchianò, A., additional, and Sozzi, G., additional
- Published
- 2019
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8. MA07.03 A Circulating MicroRNAs-Based Test as Biomarker of Primary and Secondary Resistance in PD-L1 ≥50% NSCLC Treated with Immunotherapy
- Author
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Proto, C., primary, Prelaj, A., additional, Verri, C., additional, Signorelli, D., additional, Lo Russo, G., additional, Ferrara, R., additional, Galli, G., additional, Trevisan, B., additional, Mensah, M., additional, De Braud, F., additional, Garassino, M., additional, Sozzi, G., additional, and Boeri, M., additional
- Published
- 2019
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9. Regulation of Brucella virulence by the two-component system BvrR/BvrS
- Author
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López-Goñi, I, Guzmán-Verri, C, Manterola, L, Sola-Landa, A, Moriyón, I, and Moreno, E
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- 2002
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10. Is intravesical BCG alone still the only truly effective intravesical therapy for non-muscle invasive bladder cancer?
- Author
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Di Stasi, Sm, Riedl, C, Giannantoni, A, Verri, C, Celestino, F, De Carlo, F, Masedu, Francesco, and Valenti, Marco
- Published
- 2015
11. Intravesical baobab oil in the management of bcg-induced lower urinary tract symptoms
- Author
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Verri, C, Liberati, E, De Carlo, F, and DI STASI, Sm
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Settore MED/24 - Urologia - Published
- 2013
12. The stability and electromotive administration of resiniferatoxin into the pig bladder wall
- Author
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DI STASI, Sm, Liberati, E, Verri, C, Massoud, R, Navarra, P, and Giannantoni, A
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Settore MED/24 - Urologia - Published
- 2013
13. Intravesical sequential BCG and electromotive mitomycin versus BCG alone for stage pT1 urothelial bladder cancer
- Author
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DI STASI, Sm, Verri, C, Liberati, E, Masedu, F, and Valenti, M
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Settore MED/24 - Urologia - Published
- 2013
14. Non-small cell lung cancer can be detected and its subtypes differentiated by a blood test of methylation in cell-free DNA from plasma
- Author
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Melnikov, A, Shrestha, S, Yi, Q, Replogle, C, Borgia, J, Bonomi, P, Liptay, M, Ugolini, Donatella, Neri, M, Verri, C, Sozzi, G, and Levenson, V.
- Subjects
Non-small cell lung cancer ,biomarkers - Published
- 2013
15. Intravesical Adjuvant Electromotive Mitomycin-C in Patients with Primary Intermediate-Risk Non-Muscle Invasive Bladder Cancer: A Randomized Controlled Trial
- Author
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Verri, C, Liberati, E, Topazio, L, Valenti, Marco, and Di Stasi, S.
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Settore MED/24 - Urologia - Published
- 2012
16. Intravesical adjuvant electromotive drug administration (EMDA®) of mitomycin-C in patients with intermediate-risk non-muscle invasive bladder cancer: A randomized controlled trial
- Author
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Di Stasi SM, Verri, C, Liberati, E, Micali, F, Masedu, Francesco, Zampa, G, and Valenti, Marco
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Settore MED/24 - Urologia - Published
- 2012
17. Intravesical sequential bacillus Calmette-Guérin and electromotive mitomycin versus bacillus Calmette-Guérin alone for stage pt1 urothelial bladder cancer
- Author
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Di Stasi SM, Verri, C, Liberati, E, Masedu, Francesco, Topazio, L, and Valenti, Marco
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Settore MED/24 - Urologia - Published
- 2012
18. Intravesical Sequential BCG and Elecromotive Mitomycin-C versus BCG Alone for Stage pT1 Urothelial Bladder Cancer
- Author
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Liberati, E, Verri, C, Topazio, L, Valenti, M, and DI STASI, Sm
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Settore MED/24 - Urologia - Published
- 2012
19. INTRAVESICAL ADJUVANT ELECTROMOTIVE MITOMYCIN-C IN PATIENTS WITH INTERMEDIATE-RISK NON-MUSCLE INVASIVE BLADDER CANCER: A RANDOMIZED CONTROLLED TRIAL
- Author
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DI STASI, Sm, Verri, C, Liberati, E, Micali, F, Masedu, F, and Valenti, M
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Settore MED/24 - Urologia - Published
- 2012
20. Electromotive instillation of mitomycin-immediately before transurethral resection for patients with primary urothelial non-muscle invasive bladder cancer: a randomised controlled trial
- Author
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Di Stasi SM, Valenti, Marco, Verri, C, Liberati, E, Giurioli, A, Leprini, G, Masedu, Francesco, Ricci, Ar, Micali, F, and Vespasiani, G.
- Published
- 2011
21. Single preoperative intravesical instillation of electromotive anitomycin-C for primary non-muscle-invasive bladder cancer: A prospective randonsied trial
- Author
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DI STASI, Sm, Verri, C, Capelli, G, Brausi, M, Leprini, G, Casilio, M, and Zampa, G
- Subjects
Settore MED/24 - Urologia - Published
- 2010
22. Single preoperative intravesical instillation of electromotive mitomycin-c for primary non-muscle invasive bladder cancer: a prospective randomized trial
- Author
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Liberati, E, Verri, C, Casilio, M, Brausi, M, Leprini, G, Zampa, G, Valenti, Marco, and Di Stasi, S. M.
- Subjects
Settore MED/24 - Urologia - Published
- 2010
23. Tissue pharmacokinetics of mitomycin-c in the human bladder wall after passive diffusion, thermo-chemotherapy and electromotive drug administration
- Author
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Verri, C, Liberati, E, Casilio, M, Massoud, R, Fucci, G, Dolci, S, Navarra, P, Torelli, F, and DI STASI, Sm
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Settore MED/24 - Urologia - Published
- 2010
24. 945 Is intravesical BCG alone still the only truly effective intravesical therapy for high risk nonmuscle invasive bladder cancer?
- Author
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Di Stasi, S.M., primary, Riedl, C., additional, Verri, C., additional, Celestino, F., additional, De Carlo, F., additional, Giannantoni, A., additional, and Valenti, M., additional
- Published
- 2015
- Full Text
- View/download PDF
25. Genotoxicity of air particulate organic extract in human epithelial lung cells (A549)
- Author
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Verri, C., Pagliani, T., Sallese, M., DI BUCCHIANICO, S., and Poma, Anna Maria Giuseppina
- Published
- 2009
26. Diverticolo dell'uretra femminile: raro caso di calcolosi gigante intradiverticolare
- Author
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De Carolis, A, Scarfini, M, Torelli, F, Vannozzi, E, Liberati, E, Verri, C, Iorio, B, and Spera, E
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Settore MED/24 - Urologia - Published
- 2008
27. COMPLICANZE PRECOCI E TARDIVE NELL'IMPIANTO DI PROTESI PENIENE MALLEABILI: NOSTRA ESPERIENZA
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Iorio, B, Scarfini, M, Torelli, F, Sciarra, M, Dutto, L, Verri, C, Liberati, E, and Spera, E
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Settore MED/24 - Urologia - Published
- 2008
28. Electromotive drug administration (EMDA) with mitomycyn-C for non-muscle invasive bladder cancer
- Author
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DI STASI, Sm, Dutto, L, and Verri, C
- Subjects
Settore MED/24 - Urologia - Published
- 2008
29. Intravesical electromotive drug administration of mitomycin-C for non-muscle invasive bladder cancer
- Author
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DI STASI, Sm, Liberati, E, Dutto, L, and Verri, C
- Subjects
Antibiotics, Antineoplastic ,Electrochemotherapy ,Humans ,Mitomycin ,Neoplasm Invasiveness ,Urinary Bladder Neoplasms ,Antibiotics ,Antineoplastic ,Settore MED/24 - Urologia - Published
- 2008
30. Human Brucella melitensis infections in southern Vietnam
- Author
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Campbell, J.I., Lan, N.P.H., Phuong, P.M., Chau, L.B., Trung Pham Duc, Guzmán-Verri, C., Ruiz-Villalobos, N., Minh, T.P.T., Muñoz Álvaro, P.M., Moreno, E., Thwaites, G.E., Rabaa, M.A., Chau, N.V.V., and Baker, S.
- Published
- 2017
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31. Pathology of Striped Dolphins ( Stenella coeruleoalba) Infected with Brucella ceti
- Author
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González-Barrientos, R., Morales, J.-A., Hernández-Mora, G., Barquero-Calvo, E., Guzmán-Verri, C., Chaves-Olarte, E., and Moreno, E.
- Published
- 2010
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32. Mir-660 is downregulated in lung cancer patients and its replacement inhibits lung tumorigenesis by targeting MDM2-p53 interaction
- Author
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Fortunato, O, primary, Boeri, M, additional, Moro, M, additional, Verri, C, additional, Mensah, M, additional, Conte, D, additional, Caleca, L, additional, Roz, L, additional, Pastorino, U, additional, and Sozzi, G, additional
- Published
- 2014
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33. Nervo alveolare inferiore bifido: revisione della letteratura e presentazione di un caso clinico
- Author
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Borgonovo, A.E., primary, Verri, C., additional, Bosio, P., additional, Bosio, C., additional, and Tafuro, C.M., additional
- Published
- 2014
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34. 698 Intravesical sequential BCG and electromotive mitomycin versus BCG alone for stage pT1 urothelial bladder cancer
- Author
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Di Stasi, S.M., primary, Verri, C., additional, Liberati, E., additional, Masedu, F., additional, and Valenti, M., additional
- Published
- 2013
- Full Text
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35. RISCHIO DI PATOLOGIA CARDIOVASCOLARE IN AGRICOLTURA
- Author
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Tomei, Francesco, Rosati, Maria Valeria, Danna, M, Magrini, L, Paolucci, M, Persechino, B, Ruffino, M. G., Pacchiarotti, U, Gamberale, D, Verri, C, Palmi, S, Maglione, M. F., Bosco, M. G., DI FRANCESCO, M, and Scarselli, R.
- Published
- 1996
36. 1045 Intravesical adjuvant electromotive drug administration (EMDA®) of mitomycin-C in patients with intermediate-risk non-muscle invasive bladder cancer: A randomized controlled trial
- Author
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Di Stasi, S.M., primary, Verri, C., additional, Liberati, E., additional, Micali, F., additional, Masedu, F., additional, Zampa, G., additional, and Valenti, M., additional
- Published
- 2012
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- View/download PDF
37. Concentration-depth profiles of mitomycin-C in the human bladder wall after passive diffusion, thermochemotherapy, and electromotive drug administration.
- Author
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Leprini, G., primary, Massoud, R., additional, Dolci, S., additional, Navarra, P., additional, Verri, C., additional, Torelli, F., additional, Angelini, F., additional, and Di Stasi, S. M., additional
- Published
- 2010
- Full Text
- View/download PDF
38. Single preoperative intravesical instillation of electromotive mitomycin-C for primary non-muscle-invasive bladder cancer: A prospective randomized trial.
- Author
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Di Stasi, S. M., primary, Verri, C., additional, Capelli, G., additional, Brausi, M., additional, Leprini, G., additional, Casilio, M., additional, and Zampa, G., additional
- Published
- 2010
- Full Text
- View/download PDF
39. 196 SIGLE IMMEDIATE PREOPERATIVE INTRAVESICAL INSTILLATION OF ELECTROMOTIVE MITOMYCIN-C FOR PRIMARY NON-MUSCLE INVASIVE BLADDER CANCER: A RANDOMIZED PROSPECTIVE TRIAL
- Author
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Di Stasi, S.M., primary, Verri, C., additional, Capelli, G., additional, Brausi, M., additional, Leprini, G., additional, Zampa, G., additional, and Stephen, R.L., additional
- Published
- 2010
- Full Text
- View/download PDF
40. 197 CONCENTRATION-DEPTH PROFILES OF MITOMYCIN-C IN THE HUMAN BLADDER WALL AFTER PASSIVE DIFFUSION, THERMO-CHEMOTHERAPY AND ELECTROMOTIVE DRUG ADMINISTRATION
- Author
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Di Stasi, S.M., primary, Massoud, R., additional, Dolci, S., additional, Navarra, P., additional, Fucci, G., additional, Verri, C., additional, Leprini, G., additional, Torelli, F., additional, and Stephen, R.L., additional
- Published
- 2010
- Full Text
- View/download PDF
41. Intravesical Electromotive Drug Administration® (EMDA) with Mitomycin-C for non-muscle invasive bladder cancer
- Author
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Di Stasi, S.M., primary, Dutto, L., additional, and Verri, C., additional
- Published
- 2008
- Full Text
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42. Incomplete activation of Escherichia coli hemolysin (HlyA) due to mutations in the 3' region of hlyC
- Author
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Guzmán-Verri, C, primary, García, F, additional, and Arvidson, S, additional
- Published
- 1997
- Full Text
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43. Fragile histidine triad gene inactivation in lung cancer: the European Early Lung Cancer project.
- Author
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Verri C, Roz L, Conte D, Liloglou T, Livio A, Vesin A, Fabbri A, Andriani F, Brambilla C, Tavecchio L, Calarco G, Calabrò E, Mancini A, Tosi D, Bossi P, Field JK, Brambilla E, Sozzi G, EUELC Consortium, and Verri, Carla
- Abstract
Rationale: Fragile histidine triad (FHIT) is a tumor suppressor gene involved in the pathogenesis of lung cancer.Objectives: The purpose of this study was to investigate the different molecular alterations leading to the inactivation of FHIT gene function and to validate their use as biomarkers of risk for progression of the disease in patients belonging to the multicentric European study for the Early detection of Lung Cancer (EUELC) who were resected for early-stage lung tumors.Methods: FHIT immunostaining was performed on 305 tumor samples. The methylation status of FHIT promoter was assessed by nested methylation-specific polymerase chain reaction (MSP-PCR) in 232 tumor and 225 normal lung samples of which a subset of 187 patients had available normal/tumor DNA pairs. Loss of heterozygosity (LOH) at the FHIT locus was analyzed in 202 informative cases by D3S1300 and D3S1234 microsatellite markers.Measurements and Main Results: Lost or reduced FHIT expression was found in 36.7 and 75.7% of the tumor samples, respectively. Methylation of the FHIT promoter was found in 36.7% of tumor and 32.7% of normal lung samples, whereas LOH was detected in 61.9% of the tumors. A strong association with complete loss of FHIT expression was present when methylation and LOH were analyzed together (P = 0.0064). Loss of FHIT protein expression was significantly more frequent in squamous cell carcinoma histotype (P < 0.0001) and in smokers (P = 0.008). FHIT methylation in normal lung was associated with an increased risk of progressive disease (OR, 2.27; P = 0.0415).Conclusions: Our results indicate that different molecular mechanisms interplay to inactivate FHIT expression and support the proposition that FHIT methylation in normal lung tissue could represent a prognostic marker for progressive disease. [ABSTRACT FROM AUTHOR]- Published
- 2009
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44. Plasma DNA quantification in lung cancer computed tomography screening: five-year results of a prospective study.
- Author
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Sozzi G, Roz L, Conte D, Mariani L, Andriani F, Lo Vullo S, Verri C, Pastorino U, Sozzi, Gabriella, Roz, Luca, Conte, Davide, Mariani, Luigi, Andriani, Francesca, Lo Vullo, Salvatore, Verri, Carla, and Pastorino, Ugo
- Abstract
Rationale: Free circulating plasma DNA has emerged as a potential biomarker for early lung cancer detection. In a previous case-control study we have shown that high levels of plasma DNA are a strong risk factor for lung cancer.Objectives: To assess the diagnostic performance and prognostic value of plasma DNA levels in a cohort of 1,035 heavy smokers monitored by annual spiral computed tomography (CT) for 5 years.Methods: Plasma DNA levels were determined through real-time quantitative PCR at baseline and at time of lung cancer diagnosis. Screening performance of the assay was calculated through the area under the receiver-operating characteristic curve (AUC-ROC). Kaplan-Meier analyses were computed for association with prognosis.Measurements and Main Results: Median baseline concentration of plasma DNA was not different in individuals who developed CT-detected lung cancers in the 5-year period (n = 38) versus cancer-free control subjects (AUC-ROC, 0.496; P = 0.9330), and only slightly higher at the time of cancer diagnosis (AUC-ROC, 0.607; P = 0.0369). At surgery, plasma DNA was higher in tumors detected at baseline (AUC-ROC, 0.80; P < 0.0001) and in Stage II to IV tumors detected during the first 2 years of screening (AUC-ROC, 0.87; P < 0.0001). A longitudinal study of plasma DNA levels showed increased values approaching to lung cancer diagnosis (P = 0.0010). Higher plasma DNA was significantly associated with poorer 5-year survival (P = 0.0066).Conclusions: Baseline assessment of plasma DNA level does not improve the accuracy of lung cancer screening by spiral CT in heavy smokers. Higher levels of plasma DNA at surgery might represent a risk factor for aggressive disease. [ABSTRACT FROM AUTHOR]- Published
- 2009
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45. Electromotive Drug Administration (EMDA) intravescicale con Mitomicina-C nel trattamento dei tumori della vescica non-infiltranti la muscolare.
- Author
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Di Stasi, S. M., Dutto, L., and Verri, C.
- Subjects
DRUG delivery systems ,BLADDER cancer ,DRUG delivery devices ,DOSAGE forms of drugs ,DRUG administration ,MITOMYCIN C ,ANTINEOPLASTIC antibiotics ,AMINO compounds ,CANCER treatment - Abstract
Electromotive Drug Administration® (EMDA) offers a means of controlling and enhancing the tissue transport of certain drugs, when applied to a surface epithelium, where they have a local therapeutic effect, in order to increase their efficacy. One application option is the treatment of non-muscle invasive bladder cancer with intravesical mitomycin-C (MMC). Laboratory studies demonstrated that EMDA/MMC can reduce the variability and enhance the drug administration rate into all layers of the bladder wall, and that the applied electric current causes no histological damage to tissue and no chemical modification of MMC. A prospective randomized study, performed in patients with in situ carcinoma, validated the prediction that electromotive enhancement of MMC delivery would provide results superior to those achieved using passive MMC transport. A further randomized study in patients with pTl bladder cancer demonstrated that a regimen combining intravesical BCG and EMDA/MMC increased the disease-free interval and reduced the recurrence rate, as well as the disease progression and mortality rate if compared with BCG alone. The possibility that BCG may enhance the efficacy of MMC against high-grade pTl transitional cell carcinoma and in situ carcinoma represents an important new therapeutic perspective in the high-risk non-muscle invasive bladder cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2008
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46. GTPases of the Rho subfamily are required for Brucella abortus internalization in nonprofessional phagocytes: direct activation of Cdc42.
- Author
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Guzmán-Verri, C, Chaves-Olarte, E, von Eichel-Streiber, C, López-Goñi, I, Thelestam, M, Arvidson, S, Gorvel, J P, and Moreno, E
- Abstract
Members of the genus Brucella are intracellular alpha-Proteobacteria responsible for brucellosis, a chronic disease of humans and animals. Little is known about Brucella virulence mechanisms, but the abilities of these bacteria to invade and to survive within cells are decisive factors for causing disease. Transmission electron and fluorescence microscopy of infected nonprofessional phagocytic HeLa cells revealed minor membrane changes accompanied by discrete recruitment of F-actin at the site of Brucella abortus entry. Cell uptake of B. abortus was negatively affected to various degrees by actin, actin-myosin, and microtubule chemical inhibitors. Modulators of MAPKs and protein-tyrosine kinases hampered Brucella cell internalization. Inactivation of Rho small GTPases using clostridial toxins TcdB-10463, TcdB-1470, TcsL-1522, and TcdA significantly reduced the uptake of B. abortus by HeLa cells. In contrast, cytotoxic necrotizing factor from Escherichia coli, known to activate Rho, Rac, and Cdc42 small GTPases, increased the internalization of both virulent and non-virulent B. abortus. Expression of dominant-positive Rho, Rac, and Cdc42 forms in HeLa cells promoted the uptake of B. abortus, whereas expression of dominant-negative forms of these GTPases in HeLa cells hampered Brucella uptake. Cdc42 was activated upon cell contact by virulent B. abortus, but not by a noninvasive isogenic strain, as proven by affinity precipitation of active Rho, Rac, and Cdc42. The polyphasic approach used to discern the molecular events leading to Brucella internalization provides new alternatives for exploring the complexity of the signals required by intracellular pathogens for cell invasion.
- Published
- 2001
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47. Genetic and Phenotypic Characterization of the Etiological Agent of Canine Orchiepididymitis Smooth Brucella sp. BCCN84.3
- Author
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Guzman-Verri, C. (Caterina)
- Subjects
- Materias Investigacion::Ciencias de la vida::Genética, Brucella, Brucella melitensis, Brucella suis, Brucella canis, Brucellosis, Dog, Species, Epididymitis
- Abstract
Members of the genus Brucella cluster in two phylogenetic groups: classical and non-classical species. The former group is composed of Brucella species that cause disease in mammals, including humans. A Brucella species, labeled as Brucella sp. BCCN84.3, was isolated from the testes of a Saint Bernard dog suffering orchiepididymitis, in Costa Rica. Following standard microbiological methods, the bacterium was first defined as “Brucella melitensis biovar 2.” Further molecular typing, identified the strain as an atypical “Brucella suis.” Distinctive Brucella sp. BCCN84.3 markers, absent in other Brucella species and strains, were revealed by fatty acid methyl ester analysis, high resolution melting PCR and omp25 and omp2a/omp2b gene diversity. Analysis of multiple loci variable number of tandem repeats and whole genome sequencing demonstrated that this isolate was different from the currently described Brucella species. The smooth Brucella sp. BCCN84.3 clusters together with the classical Brucella clade and displays all the genes required for virulence. Brucella sp. BCCN84.3 is a species nova taxonomical entity displaying pathogenicity; therefore, relevant for differential diagnoses in the context of brucellosis. Considering the debate on the Brucella species concept, there is a need to describe the extant taxonomical entities of these pathogens in order to understand the dispersion and evolution.
- Published
- 2019
48. Corrigendum: genetic and phenotypic characterization of the etiological agent of canine orchiepididymitis smooth brucella sp. BCCN84.3
- Author
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Guzman-Verri, C. (Caterina)
- Subjects
- Correction
- Abstract
In the original article, there was an error. In the Funding statement is written that MZ was granted with a fellowship from SEP, Universidad de Costa Rica. The correct Initials are MS-E.
- Published
- 2019
49. Effect of congenital blindness on EMG activity of the facial muscles
- Author
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Tosello, D. O., Vitti, M., Siéssere, S., Santos, C. M., Verri, C. M., Hallak, J. E. C., marisa semprini, Cecilio, F. A., and Regalo, S. C. H.
50. 40 EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004
- Author
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Veitenhansl, M., Stegner, K., Hierl, F-X, Dieterle, C., Feldmeier, H., Gutt, B., Landgraf, R., Garrow, A. P., Vileikyte, L., Findlow, A., Waterman, C., Boulton, A. J. M., Shankhdhar, K., Shankhdhar, L., Shankhdhar, U., Petrova, N. L., Foster, A. V. M., Edmonds, M. E., Ferraresi, R., Caravaggi, C., Giglio, R., Cavaiani, P., Pogliaghi, I., Sommariva, E., Katz, I. A., Harlan, A., Miranda-Palma, B., Prieto-Sanchez, L., Armstrong, D. G., Bowker, J. H., Mizel, M. S., Cernea, S., Wohlgelernter, J., Kidron, M., Modi, P., Raz, I., Arbit, E., Nosek, L., Kapitza, C., Beckett, P., Gelfand, R., Goldberg, M., Heise, T., Testa, M. A., Turner, R. R., Hayes, J. F., Scranton, R. E., Simonson, D. C., Yang, Y-W, Hsu, Y-J, Naujok, O., Francini, F., Jorns, A., Tiedge, M., Lenzen, S., Abdel-Wahab, Y. H. A., Marenah, L., Orr, D. F., Shaw, C., Flatt, P. R., Chokkalingam, K., Mansell, P. I., Clausen, P., Ekbom, P., Damm, P., Feldt-Rasmussen, U., Nielsen, B., Mathiesen, E. R., Feldt-Rasmussen, B., Dewan, S., Da Silva, N., Ternan, P. Mc, Leong, K. S., Wilding, J. P. H., Asatiani, N., Kurashvili, R., Dundua, M., Shelestova, E., Pagava, K., Ramazashvili, M., Hod, M., Smirnov, S., Petersen, J. L. A., Justesen, T. I., Ringholm Nielsen, L., Muller, C., Hojlund, K., Wensaas, A., Kase, E. T., Aas, V., Rustan, A. C., Thoresen, G. H., Levin, K., Beck-Nielsen, H., Gaster, M., Im, S-S, Kang, S-Y, Kim, S-Y, Ahn, Y-H, Lihn, A. S., Schmoll, D., Werner, T., Kienitz, A., Meyer, M., Barthel, A., Ailett, F., Sutherland, C., Walther, R., Grempler, R., Sasson, S., Reich, R., Tenenbaum, T., Alpert, E., Anfossi, G., Russo, I., Traversa, M., Massucco, P., Mattiello, L., Doronzo, G., Trovati, M., Lally, S., Tan, C. Y., Owens, D., Tomkin, G. H., Porchay, I., Pean, F., Bellili, N., Betoulle, D., Balkau, B., Tichet, J., Marre, M., Fumeron, F., Group D.E.S.I.R., Chatellier, G., Alhenc-Gelas, F., Diabhycar, Study Group, Nichols, G. A., Brown, J. B., Hayes, R. P., Bowman, L., Drexel, H., Saely, C. H., Marte, T., Benzer, W., Langer, P., Hoefle, G., Moll, W., Aczel, S., Karagiannis, E., Lubben, G., Urquhart, R., Edwards, G., Bruce, S., Howlett, H. S. C., Cugnardey, N., Turner, K. C., Park, J-S, Fiedorek, F. T., Avogaro, A., Gallo, A., Pinton, P., Rizzuto, R., Murphy, E., Ceolotto, G., Caterson, I., Guy-Grand, B., Hill, J., Barone, M., Aiello, A., Allochis, G., Borzi, V., Cannata, F., Caronna, S., D Avanzo, A., Elli, R., Formoso, G., Paroli, A., Scardapane, R., Sorichetti, P., Tatti, P., Viviani, G., Santeusanio, F., Italian Repaglinide Study Group, Manzella, D., Grella, R., Abbatecola, A. M., Paolisso, G., Sondergaard, L. G., Monster, T. B. M., Johnsen, S. P., Olsen, M. L., Mclaughlin, J. K., Sorensen, H. T., Lervang, H. H., Rungby, J., Lyssenko, V., Fredriksson, J., Almgren, P., Anevski, D., Orho-Melander, M., Sjogren, M., Tuomi, T., Groop, L., Jaziri, R., Aubert, R., Tuomilehto, J., Hu, G., Jousilahti, P., Peltonen, M., Lindstrom, J., Laina, A., Alevizaki, M., Philippou, G., Souvatzoglou, A., Anastasiou, E., Alba, S., Metcalf, B. S., Voss, L. D., Jeffery, A. N., Wilkin, T. J., Gluimer, C., Colagiuri, S., Vistisen, D., Borch-Johnsen, K., Haynes, A., Bower, C., Bulsara, M. K., Jones, T. W., Davis, E. A., Mortensen, H. B., Hougaard, P., Holl, R., Swift, P., Pociot, F., Knip, M., Hansen, L., Szadkowska, A., Pietrzak, I., Zmyslowska, A., Wyka, K., Bodalski, J., Holl, R. W., Swift, R., Hougaard, R., Gerstl, E-M, Engelsberger, I., Rabl, W., Rosenbauer, J., Grobe, H., Hofer, S. E., Krause, U., DPV-Wiss-Study Group, Dabelea, D., Morgan, T., Pettitt, D. J., Dolan, L., Mayer-Davis, E. J., Pihoker, C., Hillier, T. A., Imperatore, G., Ruggiero, A., Hamman, R. E., Stylianou, A., Tentolouris, N., Perrea, D., Tselepis, A. D., Lourida, E., Kitsou, E., Katsilambros, N., Vedovato, M., Dodesini, A. R., Lepore, G., Tiengo, A., Trevisan, R., Penno, G., Miccoli, R., Pucci, L., Lucchesi, D., Bandinelli, S., Fotino, C., Triscornia, S., Baldassari, E., Del Prato, S., Reboldi, P., Santeusanio, E., Fuller, J., Langham, R. G., Gow, R. M., Zhang, Y., Kelly, D. J., Christensen, P. K., Parving, H-H, Gilbert, R. E., Chibalin, A. V., Zhong, Z., Kotova, O., Davidescu, A., Ehren, I., Ekberg, K., Wahren, J., Wassef, L., Buckley, A. J., Rooney, K. B., Briody, J., Thompson, M., Ozanne, S. E., Thompson, C. H., Chamson-Reig, A., Summers, K., Arany, E. J. R., Hill, D. J., Solerte, S. B., Gazzaruso, C., Locatelli, E., Precerutti, S., Schifino, N., Ferrari, E., Fioravanti, M., Phenekos, C. V., Ginis, A., Fragaki, I., Chalkiadaki, M., Tzioras, C., Powell, L. A., Mcguire, G. M., Jewhurst, V., Trimble, E. R., Rasmussen, B. M., Vessby, B., Uusitupa, M., Berglund, L., Pedersen, E., Riccardi, G., Rivellese, A. A., Tapsell, L., Hermansen, K., Kanwu, Study Group, Da Silva Xavier, G., Rutter, J., Rutter, G. A., Briaud, I. M., Lingohr, M. K., Dickson, L. M., Mccuaig, J. R., Lawrence, J. C., Rhodes, C. J., Wikstrom, J. D., Katzman, S. M., Shirihai, O. S., Yang, J., Deng, S., Wang, X., Hessner, M. J., Wu, J., Wong, R. K., Sukumvanich, S., Markman, J. F., Naji, A., Wolf, B. A., Gao, Z., Rubi, B., Del Arco, A., Satrustegui, J., Maechler, P., Del Guerra, S., Lupi, R., Bugliani, M., Sbrana, S., Torri, S., Boggi, U., Vistoli, F., Mosca, F., Marchetti, P., Rennings, A. J. M., Smits, P., Stewart, M. W., Tack, C. J. J., Li, L., Nystrom, T., Gutniak, M., Ahren, B., Holst, J., Sjoholm, A., Gomes, M. B., Cailleaux, S., Tibirica, E., Albertini, J-P, Chen, H., Mather, R., Valensi, P. E., Chisalita, S. I., Arnqvist, H. J., Kraenkel, N., Adams, V., Linke, A., Gielen, S., Schuler, G., Humbrecht, R., Cipollone, F., Iezzi, A., Fazia, M., Pini, B., Cucurullo, C., Cesare, D., Schmidt, A. M., Mazurek, T., Zang, L. F., Mannion, J., Diehl, J., Martin, J., Martella, A., Zalewski, A., Shi, Y., Otter, W., Winter, M., Doering, W., Standi, E., Schnell, O., Kragelund, C., Kober, L., Faber, J., Hildebrandt, P., Steffensen, R., Pankowska, E., Szypowska, A., Lipka, M., Herwig, J., Scholl-Schilling, G., Bohles, H., Robertson, K. J., Schonle, E., Gucev, Z., Mordhorst, L., Tamer, S. C., Gall, M-A, Ludvigsson, J., Hoogma, R. P. L., Hammond, P. J., Gomis, R., Kerr, D., Bruttomesso, D., Bouter, P., Wiefels, K. J., La Calle, H., Schweitzer, D. H., Pfohl, M., Torlone, E., Krinelke, L. G., 205-Nations Study Group, Conget, I., Storms, F., Rodriguez, J., Leperlier, C., Davies, M., At Lantus, Study Group, Peter, R., Luzio, S. D., Dunseath, G., Miles, A., Hare, B., Backx, K., Pauvaday, V., Owens, D. R., Caselli, A., Marfia, G. A., Battista, C., Veves, A., Spallone, V., Uccioli, L., Gonzalez, J. S., Peyrot, M. F., Rubin, R. R., Leventhal, H., Scheffler, N., Ulbrecht, J. S., Cavanagh, P. R., Boulton, A. J., Perrin, N. A., Oglesby, A., Bastyr, E. J., Ziegler, D., Siekierka-Kleiser, E., Meyer, B., Schweers, M., Selvarajah, D., Wilkinson, I. D., Emery, C. J., Shaw, P. J., Griffiths, P. D., Tesfaye, S., Obrosova, I. G., Arezzo, J., Phillips, K., Fidarestat Study Group, Gribble, F. M., Williams, L., Reimann, F., Iakoubov, R., Whiteside, C., Brubaker, P. L., Acitores, A., Gonzalez, N., Sancho, V., Valverde, I., Villanueva-Penacarrillo, M. L., Martin-Duce, A., Trigo, M. V., Arnes, L., Burkart, V., Ichino, N., Ohashi, A., Klein, B. S., Paxian, S., Schmid, R., Karlsen, A. E., Heding, P. E., Frobose, H., Ronn, S. G., Kruhoffer, M., Orntoft, T. F., Nerup, J., Mandrup-Poulsen, T., Billestrup, N., Cardozo, A. K., Ortis, F., Feng, Y-M, Rasschaert, J., Eylen, F., Storling, J., Herchuelz, A., Eizirik, D. L., Wang, H., Kouri, G., Wollheim, C. B., Ribaux, P., Hammar, E., Parnaud, G., Rouiller, D., Bosco, D., Halban, P., Midthjell, K., Carlsson, S., Grill, V., Lau, C., Farch, K., Glumer, C., Tetens, I., Jorgensen, T., Tillin, T., Forouhi, N., Mckeigue, P., Chaturvedi, N., Zethelius, B., Hales, C. N., Berne, C., Coleman, R. L., Stevens, R. J., Holman, R. R., Christensen, J. O., Sandbak, A., Lauritzen, T., Irwin, N., Gault, V. A., Green, B. D., Harriott, P., O Harte, F. P. M., Bouman, S. D., Urso, B., Brand, C. L., Rolin, B., Ribel, U., Schaffer, L., Maggs, D. G., Ceriello, A., Frias, J. P., Wang, Y., Ruggles, J. A., Kolterman, O. G., Piconi, L., Weyer, C., Want, L. L., Ratner, R. E., Uwaifo, G. I., Thornberry, N. A., Eiermann, G., Kim, D., Lankas, G., Leiting, B., Li, Z., Lyons, K., Petrov, A., Sinha Roy, R., Woods, A., Woods, J., Zhang, B. B., Fisher, M., Moller, D. E., Weber, A. E., Dreyer, M., Bellin, C., Schmitz, V., Roesen, R., Nescheret, A. P., Bose, A. K., Mocanu, M. M., Carr, R. D., Yellon, D. M., Manolopoulos, K., Born, S., Wagner, A., Jeziorska, M., Ben Drief, A., Bashir, M., Tomlinson, D., Malik, R. A., Zeymer, U., Schwarzmaier-D Assie, A., Petzinna, D., Chiasson, J-L, Stratton, I. M., Af Bjorkesten, C-G, Fagerudd, J., Rosengard-Barlund, M., Forsblom, C., Pettersson-Fernholm, K., Waden, J., Saraheimo, M., Ronnback, M., Thorn, L., Groop, P-H, Mollsten, A., Svensson, M., Kockum, I., Rudberg, S., Brismar, K., Dahlquist, G., Hovind, P., Hansen, T. K., Tarnow, L., Thiel, S., Jensen, B. R., Flyvbjerg, A., Kankova, K., Hertlova, M., Krusova, D., Schwenke, S., Ott, J., Thom, S. A. M., Mistry, P., Sjolie, A., Larsen, B., Witt, N., Hughes, A. D., Samira, H. H., Lahiry, S., Howlader, S. R., Parveen, S., Azad Khan, A. K., Clarke, P. M., Gray, A., Stevens, R., Holman, R., Phillips, L., Phillips, P. J., Chittleborough, C., Baldock, K., Taylor, A., North West Adelaide Health Study Team, Davis, W. A., Davis, T. M. E., Knuiman, M. W., Hendrie, D., Worthley, D., Nicolucci, A., Pellegrini, F., Berardis, G., Franciosi, M., Belfiglio, M., Rossi, M. C. E., Sacco, M., Valentini, M., Richardson, C. C., Jones, P., Persaud, S., Hussain, K., Clark, A., Christie, M. R., Gniuli, D., Hribal, M. L., Accili, D., Khan, M., Zervou, S., Cheung, L., Abouna, S., Ifandi, V., Pelengaris, S., Luco, R. F., Ferrer, J., Ma, D., Shield, J. P. H., Dean, W., Leclerc, I., Knauf, C., Burcelin, R., Kelsey, G., Powers, A. C., Shostak, A., Ferrara, N., Poffenberger, G., Jerome, W. G., Brissova, M., Geloneze, S. R., Tambascia, M. A., Pareja, J. C., Chaim, E., Silveira, H. V., Geloneze, B., Ravikumar, B., Carey, P. E., Snaar, J. E., Dheelchand, D., Cook, D. B., Neely, D., Taylor, G., Morris, P. G., Taylor, R., Stears, A. J., Masding, M. G., Wootton, S. A., Sandeman, D. D., Klimes, I., Wein, S., Gasperikova, D., Ukropec, J., Wiernsperger, N., Sebokova, E., Manco, M., Mingrone, G., Granato, L., Greco, A. V., Nanni, G., Castagneto, M., Vidal, H., Calvani, M., Ferrannini, E., Alvarsson, M., Sundkvist, G., Lager, I., Henricsson, M., Berntorp, K., Fernqvist-Forbes, E., Steen, L., Orn, T., Shutler, S., Bianchi-Biscay, M., Rosenstock, J., Sugimoto, D., Strange, P., Stewart, J., Soltes Rak, E., Dailey, G., Kloos, C., Muller, U., Samann, A., Femerling, M., Risse, A., Jecht, M., Haak, T., Garg, R., Lawrence, I. G., Akinsola, M. O., Davies, M. J., Mcnally, P. G., Garber, A. J., Kim, H., Draeger, E., Aydin, L., Sengul, A., Kurklu, A., Ucak, S., Basat, O., Seber, S., Altuntas, Y., Jin, J., Yu, Y., Yu, H., Zhang, X., Mattoo, V., Eckland, D., Widel, M., Duran, S., Fajardo, C., Strand, J., Knight, D., Oakley, D., Tan, M., Sato, A., Nagao, M., Aki, N., Nakagami, T., Iwamoto, Y., Zhou, Z., Li, X., Huang, G., Yan, X., Yang, L., Peng, J., Wang, J., Tan, S., Tang, W., Furnsinn, C., Brunmair, B., Wagner, L., Gras, F., Artwohl, M., Zierhut, B., Waldhausl, W., Shine, B. 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M., Krusinova, E., Wohl, P., Klementova, M., Lanska, V., Mcdougall, C., Thomas, S. J., Kelly, I., Abbas, Z. G., Lutale, J. K., Archibald, L. K., Karunajeewa, H., Stingemore, N., Stuccio, G., Mcgechie, D., Muller, L. M. A., Hak, E., Goudzwaard, W. L., Montorsi, F., Homering, M., Sprenger, K., Goldstein, I., Asnaghi, V., Ferrari, G., Rastaldi, M., Gabellini, D., Antonio, G., Maestroni, A., Ruggieri, D., Luzi, L., Piemonti, L., Zerbini, G., Anafaroglu, I., Tutuncu, N. B., Sultana, M., Siddiqua, N., Iwasaki, T., Nakajima, A., Yoneda, M., Mukasa, K., Tanaka, S., and Sekihara, H.
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