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525 results on '"Verri, Tiziano"'

1. Phenotyping of Fecal Microbiota of Winnie, a Rodent Model of Spontaneous Chronic Colitis, Reveals Specific Metabolic, Genotoxic, and Pro-inflammatory Properties

Author

Talà, Adelfia, Guerra, Flora, Resta, Silvia Caterina, Calcagnile, Matteo, Barca, Amilcare, Tredici, Salvatore Maurizio, De Donno, Maria Dolores, Vacca, Mirco, Liso, Marina, Chieppa, Marcello, De Angelis, Maria, Verri, Tiziano, Bozzetti, Maria Giuseppina, Bucci, Cecilia, and Alifano, Pietro

Published
2022
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6. Dysregulation of a Subset of Circulating and Vesicle-Associated miRNA in Pancreatic Cancer

Author

Girolimetti, Giulia, primary, Pelisenco, Iulia Andreea, additional, Eusebi, Leonardo Henry, additional, Ricci, Claudio, additional, Cavina, Beatrice, additional, Kurelac, Ivana, additional, Verri, Tiziano, additional, Calcagnile, Matteo, additional, Alifano, Pietro, additional, Salvi, Alessandro, additional, Bucci, Cecilia, additional, and Guerra, Flora, additional

Published
2024
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10. Characterization of Chemoresistance in Pancreatic Cancer: A Look at MDR-1 Polymorphisms and Expression in Cancer Cells and Patients.

Author

Girolimetti, Giulia, Balena, Barbara, Cordella, Paola, Verri, Tiziano, Eusebi, Leonardo Henry, Bozzetti, Maria Pia, Bucci, Cecilia, and Guerra, Flora

Subjects
DRUG resistance in cancer cells, GENE expression, WESTERN immunoblotting, SINGLE nucleotide polymorphisms, PANCREATIC cancer
Abstract

Pancreatic malignancy is the fourth cause of cancer-related death in Western countries and is predicted to become the second leading cause of cancer-related mortality by 2030. The standard therapies (FOLFIRINOX and gemcitabine with nab-paclitaxel) are not resolutive because this type of cancer is also characterized by a high chemoresistance, due in part to the activity of the ATP Binding Cassette (ABC) pumps accounting for the reduction in the intracellular concentration of the drugs. In this work, we analyze the occurrence of single-nucleotide polymorphisms (SNPs) in the MDR-1 gene, in different pancreatic cancer cell lines, and in tissues from pancreatic cancer patients by DNA sequencing, as well as the expression levels of MDR-1 mRNA and protein, by qRT-PCR and Western Blot analysis. We found that gemcitabine-resistant cells, in conjunction with homozygosis of analyzed SNPs, showed high MDR-1 basal levels with further increases after gemcitabine treatment. Nevertheless, we did not observe in the human PDAC samples a correlation between the level of MDR-1 mRNA and protein expression and SNPs. Preliminary, we conclude that in our small cohort, these SNPs cannot be used as molecular markers for predicting the levels of MDR-1 mRNA/protein levels and drug responses in patients with PDAC. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Human Organ-on-a-Chip: Around the Intestine Bends

Author

Giampetruzzi, Lucia, Barca, Amilcare, De Pascali, Chiara, Capone, Simonetta, Verri, Tiziano, Siciliano, Pietro, Casino, Flavio, Francioso, Luca, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Ruediger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Andò, Bruno, editor, Baldini, Francesco, editor, Di Natale, Corrado, editor, Ferrari, Vittorio, editor, Marletta, Vincenzo, editor, Marrazza, Giovanna, editor, Militello, Valeria, editor, Miolo, Giorgia, editor, Rossi, Marco, editor, Scalise, Lorenzo, editor, and Siciliano, Pietro, editor

Published
2019
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22. Assessment of Subjective Well-Being in a Cohort of University Students and Staff Members: Association with Physical Activity and Outdoor Leisure Time during the COVID-19 Pandemic

Author

Fundação para a Ciência e a Tecnologia (Portugal), Ministério da Educação e Ciência (Portugal), Quarta, Stefano [0000-0003-1589-4177], Levante, Annalisa [0000-0002-3250-3839], García Conesa, María-Teresa [0000-0002-4125-853X], Scoditti, Egeria [0000-0003-2753-8487], Carluccio, Maria Annunziata [0000-0002-8307-1829], Calabriso, Nadia [0000-0003-0726-2081], Damiano, Fabrizio [0000-0001-7828-9519], Verri, Tiziano [0000-0003-4983-2767], Pinto, Paula [0000-0001-6379-1768], Siculella, Luisa [0000-0002-6890-3674], Quarta, Stefano, Levante, Annalisa, García-Conesa, María Teresa, Lecciso, Flavia, Scoditti, Egeria, Carluccio, Maria Annunziata, Calabriso, Nadia, Damiano, Fabrizio, Verri, Tiziano, Pinto, Paula, Siculella, Luisa, Massaro, Marika, Fundação para a Ciência e a Tecnologia (Portugal), Ministério da Educação e Ciência (Portugal), Quarta, Stefano [0000-0003-1589-4177], Levante, Annalisa [0000-0002-3250-3839], García Conesa, María-Teresa [0000-0002-4125-853X], Scoditti, Egeria [0000-0003-2753-8487], Carluccio, Maria Annunziata [0000-0002-8307-1829], Calabriso, Nadia [0000-0003-0726-2081], Damiano, Fabrizio [0000-0001-7828-9519], Verri, Tiziano [0000-0003-4983-2767], Pinto, Paula [0000-0001-6379-1768], Siculella, Luisa [0000-0002-6890-3674], Quarta, Stefano, Levante, Annalisa, García-Conesa, María Teresa, Lecciso, Flavia, Scoditti, Egeria, Carluccio, Maria Annunziata, Calabriso, Nadia, Damiano, Fabrizio, Verri, Tiziano, Pinto, Paula, Siculella, Luisa, and Massaro, Marika

Abstract

Time spent outdoors and physical activity (PA) promote mental health. To confirm this relationship in the aftermath of COVID-19 lockdowns, we explored individual levels of anxiety, depression, stress and subjective well-being (SWB) in a cohort of academic students and staff members and tested their association with sport practice, PA at leisure time and time spent outdoors. Our cross-sectional study collected data during the COVID-19 outbreak (April–May 2021) on 939 students and on 238 employees, who completed an online survey on sociodemographic and lifestyle features, depression, anxiety, stress, and SWB. Results showed that the students exhibited higher levels of anxiety, depression, and stress, and lower levels of SWB (p < 0.001 for all domains) compared to the staff members. Correlation analysis confirmed that PA and time spent in nature were associated to high mental health scores among staff and, more consistently, among students. Finally, mediation analyses indicated that the time spent in nature, social relationships, and levels of energy play a mediator role in the relationship between sport practice and SWB. Our evidence reinforces the protective role of time spent in nature in improving mental health, and provides support for policymakers to make appropriate choices for a better management of COVID-19 pandemic consequences

Published
2022

26. Hermetia illucens for Replacing Fishmeal in Aquafeeds: Effects on Fish Growth Performance, Intestinal Morphology, and Gene Expression in the Zebrafish (Danio rerio) Model

Author

Barca, Amilcare, primary, Abramo, Francesca, additional, Nazerian, Sareh, additional, Coppola, Francesca, additional, Sangiacomo, Chiara, additional, Bibbiani, Carlo, additional, Licitra, Rosario, additional, Susini, Francesca, additional, Verri, Tiziano, additional, and Fronte, Baldassare, additional

Published
2023
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29. Anorectic role of high dietary leucine in farmed Atlantic salmon (Salmo salar L.): Effects on feed intake, growth, amino acid transporters and appetite-control neuropeptides

Author

Lai, Floriana, Comesaña, Sara, Gomes, Ana S., Flatejord, Daniel, Tolås, Ingvill, Espe, Marit, De Santis, Christian, Hartviksen, Mali B., Verri, Tiziano, Soengas, Jose L., and Rønnestad, Ivar

Subjects
Aquatic Science
Abstract

Leucine has been identified to modulate feed intake and energy homeostasis in fish as in other vertebrates. Under allostatic conditions, energy expenditure may change, and adjustments to the processes that govern the energy homeostatic system may be necessary. We investigated the responsiveness of appetite-related neuropeptides involved in feed intake regulation in Atlantic salmon (Salmo salar) reared with high (35 g/kg leucine) or control (27.3 g/kg leucine) leucine-supplemented diets and/or under chronic stressor conditions (chasing) for eight weeks. We also analysed the response of amino acid transporters potentially involved in uptake of branched-chain amino acids (BCAA), including leucine, into areas of the brain where nutrient sensors may signal locally or to other areas involved in appetite control. At the end of the experiment, all fish were subjected to a novel-acute stressor (confinement). Our results show that fish fed with high leucine diet had a lower feed intake, growth, and hepatosomatic index (HSI) when compared to fish fed control leucine diet. In addition, increased mRNA expression of amino acid solute carrier (slc) genes in the diencephalon, and genes related to appetite control, such as proopiomelanocortin a1 (pomca1), in both the diencephalon and telencephalon, imply their involvement in leucine anorectic effect. Stress, as high leucine, reduced feed intake, growth and HSI of fish fed control or high leucine diet and antagonized the high leucine effect on the slc genes mRNA expression. An increase of neuropeptide y a1 (npya1) was observed both due to high dietary leucine and/or stress treatment which may represent a compensatory regulatory mechanism with the aim to reverse the decrease in feed intake. In summary, our results confirm an anorectic role of high dietary leucine via the activation of amino acid sensing mechanisms in the brain. Further, corticotropin-releasing hormone 1 b1 (crh1b1) and npya1 showed to play a role in the regulation of appetite in Atlantic salmon under stress conditions and/or high leucine levels. publishedVersion

Published
2023

32. Identification of SLC15A4/PHT1 Gene Products Upregulation Marking the Intestinal Epithelial Monolayer of Ulcerative Colitis Patients

Author

Mazzei, Aurora, primary, Serino, Grazia, additional, Romano, Alessandro, additional, Piccinno, Emanuele, additional, Scalavino, Viviana, additional, Valentini, Anna Maria, additional, Armentano, Raffaele, additional, Schiavone, Roberta, additional, Giannelli, Gianluigi, additional, Verri, Tiziano, additional, and Barca, Amilcare, additional

Published
2022
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33. Analysis of the Anti-Inflammatory and Anti-Osteoarthritic Potential of Flonat Fast®, a Combination of Harpagophytum Procumbens DC. ex Meisn., Boswellia Serrata Roxb., Curcuma longa L., Bromelain and Escin (Aesculus hippocastanum), Evaluated in In Vitro Models of Inflammation Relevant to Osteoarthritis

Author

Quarta, Stefano, primary, Santarpino, Giuseppe, additional, Carluccio, Maria Annunziata, additional, Calabriso, Nadia, additional, Scoditti, Egeria, additional, Siculella, Luisa, additional, Damiano, Fabrizio, additional, Maffia, Michele, additional, Verri, Tiziano, additional, De Caterina, Raffaele, additional, and Massaro, Marika, additional

Published
2022
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39. Phenotyping of fecal microbiota of Winnie, a rodent model of spontaneous chronic colitis, reveals specific metabolic, genotoxic, and pro-inflammatory properties

Author

Talà, Adelfia, primary, Guerra, Flora, additional, Resta, Silvia Caterina, additional, Calcagnile, Matteo, additional, Barca, Amilcare, additional, Tredici, Salvatore Maurizio, additional, De Donno, Maria Dolores, additional, Vacca, Mirco, additional, Liso, Marina, additional, Chieppa, Marcello, additional, De Angelis, Maria, additional, Verri, Tiziano, additional, Bozzetti, Maria Giuseppina, additional, Bucci, Cecilia, additional, and Alifano, Pietro, additional

Published
2022
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41. Assessment of Subjective Well-Being in a Cohort of University Students and Staff Members: Association with Physical Activity and Outdoor Leisure Time during the COVID-19 Pandemic

Author

Quarta, Stefano, primary, Levante, Annalisa, additional, García-Conesa, María-Teresa, additional, Lecciso, Flavia, additional, Scoditti, Egeria, additional, Carluccio, Maria Annunziata, additional, Calabriso, Nadia, additional, Damiano, Fabrizio, additional, Santarpino, Giuseppe, additional, Verri, Tiziano, additional, Pinto, Paula, additional, Siculella, Luisa, additional, and Massaro, Marika, additional

Published
2022
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50. Cytoskeletal Responses and Aif-1 Expression in Caco-2 Monolayers Exposed to Phorbol-12-Myristate-13-Acetate and Carnosine.

Author

Mazzei, Aurora, Pagliara, Patrizia, Del Vecchio, Gianmarco, Giampetruzzi, Lucia, Croce, Francesca, Schiavone, Roberta, Verri, Tiziano, and Barca, Amilcare

Subjects
CYTOSKELETAL proteins, MONOMOLECULAR films, CARNOSINE, CYTOSKELETON, CELL differentiation, GASTROINTESTINAL system, TIGHT junctions
Abstract

Simple Summary: The functionality of the enterocyte monolayer is directly impaired by inflammatory insults targeting the major cellular processes, including the cytoskeletal dynamics involving actin elements. Enterocyte's actin cytoskeleton plays key roles in maintaining the epithelial monolayer's integrity, and its remodeling is critically intertwined with the transition from physiological to pathological states of the gastrointestinal epithelial barrier challenged by inflammation onsets. Hence, understanding the behavior of the actin cytoskeleton in enterocytes forming the epithelial monolayer is a primary aim for clarifying fundamental aspects of inflammatory mechanisms in the gastrointestinal tract. Here, we analyzed the changing aspects of cytoskeletal actin in the human Caco-2 epithelial cell model at two different stages of differentiation: undifferentiated cells and spontaneously differentiated enterocyte-like cells. An in vitro inflammation-mimicking stimulus (phorbol-12-myristate-13-acetate) was used for challenging intestinal epithelial cells in association with the naturally occurring carnosine dipeptide, which showed its potential counteraction against alterations of the actin cytoskeleton in the enterocyte-like monolayers. Through such experiments, for the first time, we described in enterocyte-like monolayers the expression, localization, and variations of the allograft inflammatory factor 1, a protein functionally related to both inflammatory and cytoskeletal pathways, that we suggest considering as interesting features potentially marking the intestinal epithelial monolayers. The dis(re)organization of the cytoskeletal actin in enterocytes mediates epithelial barrier dys(re)function, playing a key role in modulating epithelial monolayer's integrity and remodeling under transition from physiological to pathological states. Here, by fluorescence-based morphological and morphometric analyses, we detected differential responses of cytoskeletal actin in intestinal epithelial Caco-2 cell monolayers at two different stages of their spontaneous differentiation, i.e., undifferentiated cells at 7 days post-seeding (dps) and differentiated enterocyte-like cells at 21 dps, upon challenge in vitro with the inflammation-mimicking stimulus of phorbol-12-myristate-13-acetate (PMA). In addition, specific responses were found in the presence of the natural dipeptide carnosine detecting its potential counteraction against PMA-induced cytoskeletal alterations and remodeling in differentiated Caco-2 monolayers. In such an experimental context, by both immunocytochemistry and Western blot assays in Caco-2 monolayers, we identified the expression of the allograft inflammatory factor 1 (AIF-1) as protein functionally related to both inflammatory and cytoskeletal pathways. In 21 dps monolayers, particularly, we detected variations of its intracellular localization associated with the inflammatory stimulus and its mRNA/protein increase associated with the differentiated 21 dps enterocyte-like monolayer compared to the undifferentiated cells. [ABSTRACT FROM AUTHOR]

Published
2023
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