1. Anti-AT1R autoantibodies and prediction of the severity of Covid-19
- Author
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Carla Cervelli, Franco Marinangeli, Anna Cecilia Carucci, Alessandro Grimaldi, Vincenza Cofini, Chiara Angeletti, Stefano Necozione, Franco Papola, Veronica Biancofiore, and Alessia Rosciano
- Subjects
Adult ,Male ,Angiotensin II ,AT1R autoantibodies ,SARS-CoV-2 infection ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Short Communication ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Immunology ,Stimulation ,Autoantigens ,SARS-CoV-2, severe acute respiratory syndrome coronavirus 2 ,Gastroenterology ,Receptor, Angiotensin, Type 1 ,Internal medicine ,medicine ,Humans ,Immunology and Allergy ,Respiratory system ,AngII, Angiotensin II ,Aged ,Autoantibodies ,Retrospective Studies ,Aged, 80 and over ,Angiotensin II receptor type 1 ,SARS-CoV-2 ,business.industry ,Autoantibody ,COVID-19 ,General Medicine ,Middle Aged ,medicine.disease ,ACE-2, Angiotensin Converting Enzyme ,Hospitalization ,Italy ,Female ,business ,Cytokine storm ,AT1Rab, autoantibodies direct vs Angiotensin II Receptor1 - Abstract
The stimulation of AT1R (Angiotensin II Receptor Type 1) by Angiotensin II has, in addition to the effects on the renin-angiotensin system, also pro-inflammatory effects through stimulation of ADAM17 and subsequent production of INF-gamma and Interleukin-6. This pro-inflammatory action stimulate the cytokine storm that characterizes the most severe forms of SARS-CoV-2 infection. We studied the effect of AT1Rab on the AT1R on 74 subjects with SARS-CoV-2 infection with respiratory symptoms requiring hospitalization. We divided the patients into 2 groups: 34 with moderate and 40 with severe symptoms that required ICU admission. Hospitalized subjects showed a 50% reduction in the frequency of AT1Rab compared to healthy reference population. Of the ICU patients, 33/40 (82.5%) were AT1Rab negative and 16/33 of them (48.5%) died. All 7 patients positive for AT1Rab survived. These preliminary data seem to indicate a protective role played by AT1R autoantibodies on inflammatory activation in SARS-CoV-2 infection pathology.
- Published
- 2022
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