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Your search keyword '"Vernooij, L. M."' showing total 17 results
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17 results on '"Vernooij, L. M."'

3. The effect of postoperative intravenous iron in anaemic, older cardiac surgery patients on disability-free survival (AGE ANEMIA study): study protocol for a multi-centre, double-blind, randomized, placebo-controlled trial

Author

Onderzoek, Infection & Immunity, Sepsis and Inflammation, Smoor, R M, Rettig, T C D, Vernooij, L M, Groenewegen, E M, van Dongen, H P A, Noordzij, P G, Onderzoek, Infection & Immunity, Sepsis and Inflammation, Smoor, R M, Rettig, T C D, Vernooij, L M, Groenewegen, E M, van Dongen, H P A, and Noordzij, P G

Published
2023

4. Quality of recovery after day care surgery with app-controlled remote monitoring: study protocol for a randomized controlled trial

Author

Onderzoek Heart at Risk, Onderzoek, Medische staf Anesthesiologie, Thiel, B., Godfried, M. B., van Emst, M. E., Vernooij, L. M., van Vliet, L. M., Rumke, E., van Dongen, R. T.M., Gerrits, W., Koopman, J. S.H.A., Kalkman, C. J., Onderzoek Heart at Risk, Onderzoek, Medische staf Anesthesiologie, Thiel, B., Godfried, M. B., van Emst, M. E., Vernooij, L. M., van Vliet, L. M., Rumke, E., van Dongen, R. T.M., Gerrits, W., Koopman, J. S.H.A., and Kalkman, C. J.

Published
2023

5. Performance and usability of pre-operative prediction models for 30-day peri-operative mortality risk: a systematic review

Author

DHS-Bedrijfsvoering 2, Geneeskunde, Medische staf Anesthesiologie, Onderzoek, Vernooij, J. E.M., Koning, N. J., Geurts, J. W., Holewijn, S., Preckel, B., Kalkman, C. J., Vernooij, L. M., DHS-Bedrijfsvoering 2, Geneeskunde, Medische staf Anesthesiologie, Onderzoek, Vernooij, J. E.M., Koning, N. J., Geurts, J. W., Holewijn, S., Preckel, B., Kalkman, C. J., and Vernooij, L. M.

Published
2023

13. The effect of remote ischaemic preconditioning on postoperative cardiac and inflammatory biomarkers in pancreatic surgery: a randomized controlled trial

Author

Onderzoek, Genetica, MS CGO, Cancer, MS HOD, van Zeggeren, L., Visser, R. A., Vernooij, L. M., Dijkstra, I. M., Bosma, M., Molenaar, Q., van Santvoort, H. C., Noordzij, P. G., Onderzoek, Genetica, MS CGO, Cancer, MS HOD, van Zeggeren, L., Visser, R. A., Vernooij, L. M., Dijkstra, I. M., Bosma, M., Molenaar, Q., van Santvoort, H. C., and Noordzij, P. G.

Published
2021

16. Different methods of modelling intraoperative hypotension and their association with postoperative complications in patients undergoing non-cardiac surgery

Author

Epi Methoden Team 3, Onderzoek Heart at Risk, Management Vitale Functies, Circulatory Health, Trialbureau Vitale Functies, Infection & Immunity, JC onderzoeksprogramma Methodologie, Vernooij, L. M., van Klei, W. A., Machina, M., Pasma, W., Beattie, W. S., Peelen, L. M., Epi Methoden Team 3, Onderzoek Heart at Risk, Management Vitale Functies, Circulatory Health, Trialbureau Vitale Functies, Infection & Immunity, JC onderzoeksprogramma Methodologie, Vernooij, L. M., van Klei, W. A., Machina, M., Pasma, W., Beattie, W. S., and Peelen, L. M.

Published
2018

17. Postoperative myocardial injury and platelet reactivity in patients undergoing vascular surgery: The platelet reactivity and postoperative myocardial injury after major vascular surgery (PROMISE) study.

Author

Zheng KL, Bor WL, Vernooij LM, Breet NC, Kelder JC, Hackeng CM, Kropman RHJ, Ten Berg JM, and Noordzij PG

Subjects
Humans, Adenosine Diphosphate, Aspirin, Cohort Studies, Diterpenes, Myocardium, P-Selectin, Postoperative Period, Prospective Studies, Troponin, Heart Injuries, Platelet Activation, Vascular Surgical Procedures adverse effects
Abstract

Background: Postoperative myocardial injury (PMI) after major vascular surgery, detected by elevated cardiac troponin (cTn), has been associated with morbidity and mortality. It is unclear whether the pathophysiology of PMI is determined by increased platelet activity., Objective: To examine the relationship between platelet activation (P-selectin expression) and PMI in patients undergoing elective open abdominal aortic surgery., Methods: This prospective, single-centre, observational, cohort study included 33 patients undergoing elective open abdominal aortic surgery between March 2018 and April 2021. Patients were routinely treated with aspirin. Unstimulated platelet activation was measured by platelet bound P-selectin expression (range 0-100 %). Explorative coagulation measurements were: stimulated platelet aggregation measured with the VerifyNow® assay (aspirin cartridge), with the Multiplate® analyzer (ASPI, ADP and TRAP) and stimulated coagulation status evaluated by the TEG® Hemostasis Analyzer System (global hemostasis cartridge). The primary outcome was cTn release assessed by the fifth generation high-sensitive cTn assay. Multivariable generalized linear mixed models were used to evaluate the association between platelet function and cTn concentrations over time., Results: Ten patients (30.3 %) developed PMI. Increased P-selectin expression directly after surgery was associated with the cTn concentrations over 48 h (β = 1.39 (1.1-1.75), P = 0.0064). No association was found between P-selectin measured later after surgery (at 24 h or 48 h) and cTn concentrations. Furthermore, there was no association between the explorative coagulation parameters and cTn release., Conclusion: Platelet reactivity, assessed by P-selectin expression measured directly after surgery is associated with PMI, assessed by elevated cTn concentrations in the early postoperative period in patients undergoing elective open abdominal aortic surgery., (Copyright © 2022 Elsevier Ltd. All rights reserved.)

Published
2022
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