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505 results on '"Vermeulen, Peter B."'

1. Reproducible radiomics through automated machine learning validated on twelve clinical applications

Author

Starmans, Martijn P. A., van der Voort, Sebastian R., Phil, Thomas, Timbergen, Milea J. M., Vos, Melissa, Padmos, Guillaume A., Kessels, Wouter, Hanff, David, Grunhagen, Dirk J., Verhoef, Cornelis, Sleijfer, Stefan, Bent, Martin J. van den, Smits, Marion, Dwarkasing, Roy S., Els, Christopher J., Fiduzi, Federico, van Leenders, Geert J. L. H., Blazevic, Anela, Hofland, Johannes, Brabander, Tessa, van Gils, Renza A. H., Franssen, Gaston J. H., Feelders, Richard A., de Herder, Wouter W., Buisman, Florian E., Willemssen, Francois E. J. A., Koerkamp, Bas Groot, Angus, Lindsay, van der Veldt, Astrid A. M., Rajicic, Ana, Odink, Arlette E., Deen, Mitchell, T., Jose M. Castillo, Veenland, Jifke, Schoots, Ivo, Renckens, Michel, Doukas, Michail, de Man, Rob A., IJzermans, Jan N. M., Miclea, Razvan L., Vermeulen, Peter B., Bron, Esther E., Thomeer, Maarten G., Visser, Jacob J., Niessen, Wiro J., and Klein, Stefan

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition
Abstract

Radiomics uses quantitative medical imaging features to predict clinical outcomes. Currently, in a new clinical application, finding the optimal radiomics method out of the wide range of available options has to be done manually through a heuristic trial-and-error process. In this study we propose a framework for automatically optimizing the construction of radiomics workflows per application. To this end, we formulate radiomics as a modular workflow and include a large collection of common algorithms for each component. To optimize the workflow per application, we employ automated machine learning using a random search and ensembling. We evaluate our method in twelve different clinical applications, resulting in the following area under the curves: 1) liposarcoma (0.83); 2) desmoid-type fibromatosis (0.82); 3) primary liver tumors (0.80); 4) gastrointestinal stromal tumors (0.77); 5) colorectal liver metastases (0.61); 6) melanoma metastases (0.45); 7) hepatocellular carcinoma (0.75); 8) mesenteric fibrosis (0.80); 9) prostate cancer (0.72); 10) glioma (0.71); 11) Alzheimer's disease (0.87); and 12) head and neck cancer (0.84). We show that our framework has a competitive performance compared human experts, outperforms a radiomics baseline, and performs similar or superior to Bayesian optimization and more advanced ensemble approaches. Concluding, our method fully automatically optimizes the construction of radiomics workflows, thereby streamlining the search for radiomics biomarkers in new applications. To facilitate reproducibility and future research, we publicly release six datasets, the software implementation of our framework, and the code to reproduce this study., Comment: 33 pages, 4 figures, 4 tables, 2 supplementary figures, 3 supplementary table, submitted to Medical Image Analysis; revision

Published
2021

2. An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver

Author

Fernández Moro, Carlos, Geyer, Natalie, Harrizi, Sara, Hamidi, Yousra, Söderqvist, Sara, Kuznyecov, Danyil, Tidholm Qvist, Evelina, Salmonson Schaad, Media, Hermann, Laura, Lindberg, Amanda, Heuchel, Rainer L., Martín-Bernabé, Alfonso, Dhanjal, Soniya, Navis, Anna C., Villard, Christina, del Valle, Andrea C., Bozóky, Lorand, Sparrelid, Ernesto, Dirix, Luc, Strell, Carina, Östman, Arne, Schmierer, Bernhard, Vermeulen, Peter B., Engstrand, Jennie, Bozóky, Béla, and Gerling, Marco

Published
2023
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3. Histopathological growth patterns of liver metastasis: updated consensus guidelines for pattern scoring, perspectives and recent mechanistic insights

Author

Latacz, Emily, Höppener, Diederik, Bohlok, Ali, Leduc, Sophia, Tabariès, Sébastien, Fernández Moro, Carlos, Lugassy, Claire, Nyström, Hanna, Bozóky, Béla, Floris, Giuseppe, Geyer, Natalie, Brodt, Pnina, Llado, Laura, Van Mileghem, Laura, De Schepper, Maxim, Majeed, Ali W., Lazaris, Anthoula, Dirix, Piet, Zhang, Qianni, Petrillo, Stéphanie K., Vankerckhove, Sophie, Joye, Ines, Meyer, Yannick, Gregorieff, Alexander, Roig, Nuria Ruiz, Vidal-Vanaclocha, Fernando, Denis, Larsimont, Oliveira, Rui Caetano, Metrakos, Peter, Grünhagen, Dirk J., Nagtegaal, Iris D., Mollevi, David G., Jarnagin, William R., D’Angelica, Michael I, Reynolds, Andrew R., Doukas, Michail, Desmedt, Christine, Dirix, Luc, Donckier, Vincent, Siegel, Peter M., Barnhill, Raymond, Gerling, Marco, Verhoef, Cornelis, and Vermeulen, Peter B.

Published
2022
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6. Predicting 10-year survival after resection of colorectal liver metastases; an international study including biomarkers and perioperative treatment

Author

Buisman, Florian E., Giardiello, Daniele, Kemeny, Nancy E., Steyerberg, Ewout W., Höppener, Diederik J., Galjart, Boris, Nierop, Pieter M.H., Balachandran, Vinod P., Cercek, Andrea, Drebin, Jeffrey A., Gönen, Mithat, Jarnagin, William R., Kingham, T.P., Vermeulen, Peter B., Wei, Alice C., Grünhagen, Dirk J., Verhoef, Cornelis, D'Angelica, Micheal I., and Koerkamp, Bas Groot

Published
2022
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11. Consensus guidelines for the use and interpretation of angiogenesis assays

Author

Nowak-Sliwinska, Patrycja, Alitalo, Kari, Allen, Elizabeth, Anisimov, Andrey, Aplin, Alfred C, Auerbach, Robert, Augustin, Hellmut G, Bates, David O, van Beijnum, Judy R, Bender, R Hugh F, Bergers, Gabriele, Bikfalvi, Andreas, Bischoff, Joyce, Böck, Barbara C, Brooks, Peter C, Bussolino, Federico, Cakir, Bertan, Carmeliet, Peter, Castranova, Daniel, Cimpean, Anca M, Cleaver, Ondine, Coukos, George, Davis, George E, De Palma, Michele, Dimberg, Anna, Dings, Ruud PM, Djonov, Valentin, Dudley, Andrew C, Dufton, Neil P, Fendt, Sarah-Maria, Ferrara, Napoleone, Fruttiger, Marcus, Fukumura, Dai, Ghesquière, Bart, Gong, Yan, Griffin, Robert J, Harris, Adrian L, Hughes, Christopher CW, Hultgren, Nan W, Iruela-Arispe, M Luisa, Irving, Melita, Jain, Rakesh K, Kalluri, Raghu, Kalucka, Joanna, Kerbel, Robert S, Kitajewski, Jan, Klaassen, Ingeborg, Kleinmann, Hynda K, Koolwijk, Pieter, Kuczynski, Elisabeth, Kwak, Brenda R, Marien, Koen, Melero-Martin, Juan M, Munn, Lance L, Nicosia, Roberto F, Noel, Agnes, Nurro, Jussi, Olsson, Anna-Karin, Petrova, Tatiana V, Pietras, Kristian, Pili, Roberto, Pollard, Jeffrey W, Post, Mark J, Quax, Paul HA, Rabinovich, Gabriel A, Raica, Marius, Randi, Anna M, Ribatti, Domenico, Ruegg, Curzio, Schlingemann, Reinier O, Schulte-Merker, Stefan, Smith, Lois EH, Song, Jonathan W, Stacker, Steven A, Stalin, Jimmy, Stratman, Amber N, Van de Velde, Maureen, van Hinsbergh, Victor WM, Vermeulen, Peter B, Waltenberger, Johannes, Weinstein, Brant M, Xin, Hong, Yetkin-Arik, Bahar, Yla-Herttuala, Seppo, Yoder, Mervin C, and Griffioen, Arjan W

Subjects
Biochemistry and Cell Biology, Biological Sciences, Regenerative Medicine, Animals, Biological Assay, Guidelines as Topic, Humans, Mice, Neoplasms, Neovascularization, Pathologic, Angiogenesis, Aortic ring, Endothelial cell migration, Proliferation, Microfluidic, Zebrafish, Chorioallantoic membrane, Vascular network, Intussusceptive angiogenesis, Retinal vasculature, Corneal angiogenesis, Hindlimb ischemia, Myocardial angiogenesis, Recombinant proteins, Tip cells, Plug assay, Vessel co-option, Clinical Sciences, Pharmacology and Pharmaceutical Sciences, Oncology & Carcinogenesis, Biochemistry and cell biology
Abstract

The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation. As such, this collaborative work is the first edition of consensus guidelines on angiogenesis bioassays to serve for current and future reference.

Published
2018

13. Transcriptomic characterization of the histopathological growth patterns in breast cancer liver metastases

Author

Leduc, Sophia, Nguyen, Ha Linh, Richard, François, Zels, Gitte, Mahdami, Amena, De Schepper, Maxim, Maetens, Marion M., Pabba, Anirudh, Jaekers, Joris, Latacz, Emily, Bohlok, Ali, Vanderheyden, Evy, Van Brussel, Thomas, Boeckx, Bram, Schepers, Rogier, Lambrechts, Diether, DIrix, Luc, Larsimont, Denis, Vankerckhove, Sophie, Lucidi, Valerio, Topal, Baki, Bachir, Imane, Donckier De Donceel, Vincent, Floris, Giuseppe, Vermeulen, Peter B., Desmedt, Christine, Leduc, Sophia, Nguyen, Ha Linh, Richard, François, Zels, Gitte, Mahdami, Amena, De Schepper, Maxim, Maetens, Marion M., Pabba, Anirudh, Jaekers, Joris, Latacz, Emily, Bohlok, Ali, Vanderheyden, Evy, Van Brussel, Thomas, Boeckx, Bram, Schepers, Rogier, Lambrechts, Diether, DIrix, Luc, Larsimont, Denis, Vankerckhove, Sophie, Lucidi, Valerio, Topal, Baki, Bachir, Imane, Donckier De Donceel, Vincent, Floris, Giuseppe, Vermeulen, Peter B., and Desmedt, Christine

Abstract

Metastatic breast cancer (mBC) remains incurable and liver metastases (LM) are observed in approximately 50% of all patients with mBC. In some cases, surgical resection of breast cancer liver metastases (BCLM) is associated with prolonged survival. However, there are currently no validated marker to identify these patients. The interactions between the metastatic cancer cells and the liver microenvironment result in two main histopathological growth patterns (HGP): replacement (r-HGP), characterized by a direct contact between the cancer cells and the hepatocytes, and desmoplastic (d-HGP), in which a fibrous rim surrounds the tumor cells. In patients who underwent resection of BCLM, the r-HGP is associated with a worse postoperative prognosis than the d-HGP. Here, we aim at unraveling the biological differences between these HGP within ten patients presenting both HGP within the same metastasis. The transcriptomic analyses reveal overexpression of genes involved in cell cycle, DNA repair, vessel co-option and cell motility in r-HGP while angiogenesis, wound healing, and several immune processes were found overexpressed in d-HGP LM. Understanding the biology of the LM could open avenues to refine treatment of BC patients with LM., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2024

14. Histopathological growth patterns as biomarker for adjuvant systemic chemotherapy in patients with resected colorectal liver metastases

Author

Buisman, Florian E., van der Stok, Eric P., Galjart, Boris, Vermeulen, Peter B., Balachandran, Vinod P., Coebergh van den Braak, Robert R. J., Creasy, John M., Höppener, Diederik J., Jarnagin, William R., Kingham, T. Peter, Nierop, Pieter M. H., Sadot, Eran, Shia, Jinru, Groot Koerkamp, Bas, Grünhagen, Dirk J., D’Angelica, Michael, and Verhoef, Cornelis

Published
2020
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25. Supplementary Figures 1-5 and Supplementary Table 1 from Preclinical Evidence That Trametinib Enhances the Response to Antiangiogenic Tyrosine Kinase Inhibitors in Renal Cell Carcinoma

Author

Bridgeman, Victoria L., primary, Wan, Elaine, primary, Foo, Shane, primary, Nathan, Mark R., primary, Welti, Jonathan C., primary, Frentzas, Sophia, primary, Vermeulen, Peter B., primary, Preece, Natasha, primary, Springer, Caroline J., primary, Powles, Thomas, primary, Nathan, Paul D., primary, Larkin, James, primary, Gore, Martin, primary, Vasudev, Naveen S., primary, and Reynolds, Andrew R., primary

Published
2023
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30. Table S3 from XIAP Regulation by MNK Links MAPK and NFκB Signaling to Determine an Aggressive Breast Cancer Phenotype

Author

Evans, Myron K., primary, Brown, Michael C., primary, Geradts, Joseph, primary, Bao, Xuhui, primary, Robinson, Timothy J., primary, Jolly, Mohit Kumar, primary, Vermeulen, Peter B., primary, Palmer, Gregory M., primary, Gromeier, Matthias, primary, Levine, Herbert, primary, Morse, Michael A., primary, Van Laere, Steven J., primary, and Devi, Gayathri R., primary

Published
2023
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31. Supplementary Table 2 from Gene Expression Profiles Associated with the Presence of a Fibrotic Focus and the Growth Pattern in Lymph Node–Negative Breast Cancer

Author

Van den Eynden, Gert G., primary, Smid, Marcel, primary, Van Laere, Steven J., primary, Colpaert, Cecile G., primary, Van der Auwera, Ilse, primary, Bich, Trinh Xuan, primary, van Dam, Peter, primary, den Bakker, Michael A., primary, Dirix, Luc Y., primary, Van Marck, Eric A., primary, Vermeulen, Peter B., primary, and Foekens, John A., primary

Published
2023
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32. Data from XIAP Regulation by MNK Links MAPK and NFκB Signaling to Determine an Aggressive Breast Cancer Phenotype

Author

Evans, Myron K., primary, Brown, Michael C., primary, Geradts, Joseph, primary, Bao, Xuhui, primary, Robinson, Timothy J., primary, Jolly, Mohit Kumar, primary, Vermeulen, Peter B., primary, Palmer, Gregory M., primary, Gromeier, Matthias, primary, Levine, Herbert, primary, Morse, Michael A., primary, Van Laere, Steven J., primary, and Devi, Gayathri R., primary

Published
2023
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33. Supplementary Figure from Suppression of Endothelial Cell FAK Expression Reduces Pancreatic Ductal Adenocarcinoma Metastasis after Gemcitabine Treatment

Author

Roy-Luzarraga, Marina, primary, Reynolds, Louise E., primary, de Luxán-Delgado, Beatriz, primary, Maiques, Oscar, primary, Wisniewski, Laura, primary, Newport, Emma, primary, Rajeeve, Vinothini, primary, Drake, Rebecca J.G., primary, Gómez-Escudero, Jesús, primary, Richards, Frances M., primary, Weller, Céline, primary, Dormann, Christof, primary, Meng, Ya-Ming, primary, Vermeulen, Peter B., primary, Saur, Dieter, primary, Sanz-Moreno, Victoria, primary, Wong, Ping-Pui, primary, Géraud, Cyrill, primary, Cutillas, Pedro R., primary, and Hodivala-Dilke, Kairbaan, primary

Published
2023
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34. Supplementary Figures and Tables from XIAP Regulation by MNK Links MAPK and NFκB Signaling to Determine an Aggressive Breast Cancer Phenotype

Author

Evans, Myron K., primary, Brown, Michael C., primary, Geradts, Joseph, primary, Bao, Xuhui, primary, Robinson, Timothy J., primary, Jolly, Mohit Kumar, primary, Vermeulen, Peter B., primary, Palmer, Gregory M., primary, Gromeier, Matthias, primary, Levine, Herbert, primary, Morse, Michael A., primary, Van Laere, Steven J., primary, and Devi, Gayathri R., primary

Published
2023
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35. Supplementary Data from Suppression of Endothelial Cell FAK Expression Reduces Pancreatic Ductal Adenocarcinoma Metastasis after Gemcitabine Treatment

Author

Roy-Luzarraga, Marina, primary, Reynolds, Louise E., primary, de Luxán-Delgado, Beatriz, primary, Maiques, Oscar, primary, Wisniewski, Laura, primary, Newport, Emma, primary, Rajeeve, Vinothini, primary, Drake, Rebecca J.G., primary, Gómez-Escudero, Jesús, primary, Richards, Frances M., primary, Weller, Céline, primary, Dormann, Christof, primary, Meng, Ya-Ming, primary, Vermeulen, Peter B., primary, Saur, Dieter, primary, Sanz-Moreno, Victoria, primary, Wong, Ping-Pui, primary, Géraud, Cyrill, primary, Cutillas, Pedro R., primary, and Hodivala-Dilke, Kairbaan, primary

Published
2023
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36. Supplementary Table 3 from Gene Expression Profiles Associated with the Presence of a Fibrotic Focus and the Growth Pattern in Lymph Node–Negative Breast Cancer

Author

Van den Eynden, Gert G., primary, Smid, Marcel, primary, Van Laere, Steven J., primary, Colpaert, Cecile G., primary, Van der Auwera, Ilse, primary, Bich, Trinh Xuan, primary, van Dam, Peter, primary, den Bakker, Michael A., primary, Dirix, Luc Y., primary, Van Marck, Eric A., primary, Vermeulen, Peter B., primary, and Foekens, John A., primary

Published
2023
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37. Supplementary Table 1 from Gene Expression Profiles Associated with the Presence of a Fibrotic Focus and the Growth Pattern in Lymph Node–Negative Breast Cancer

Author

Van den Eynden, Gert G., primary, Smid, Marcel, primary, Van Laere, Steven J., primary, Colpaert, Cecile G., primary, Van der Auwera, Ilse, primary, Bich, Trinh Xuan, primary, van Dam, Peter, primary, den Bakker, Michael A., primary, Dirix, Luc Y., primary, Van Marck, Eric A., primary, Vermeulen, Peter B., primary, and Foekens, John A., primary

Published
2023
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38. Data from Suppression of Endothelial Cell FAK Expression Reduces Pancreatic Ductal Adenocarcinoma Metastasis after Gemcitabine Treatment

Author

Roy-Luzarraga, Marina, primary, Reynolds, Louise E., primary, de Luxán-Delgado, Beatriz, primary, Maiques, Oscar, primary, Wisniewski, Laura, primary, Newport, Emma, primary, Rajeeve, Vinothini, primary, Drake, Rebecca J.G., primary, Gómez-Escudero, Jesús, primary, Richards, Frances M., primary, Weller, Céline, primary, Dormann, Christof, primary, Meng, Ya-Ming, primary, Vermeulen, Peter B., primary, Saur, Dieter, primary, Sanz-Moreno, Victoria, primary, Wong, Ping-Pui, primary, Géraud, Cyrill, primary, Cutillas, Pedro R., primary, and Hodivala-Dilke, Kairbaan, primary

Published
2023
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40. An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver

Author

Moro, Carlos Fernandez, Geyer, Natalie, Harrizi, Sara, Hamidi, Yousra, Söderqvist, Sara, Kuznyecov, Danyil, Tidholm Qvist, Evelina, Salmonson Schaad, Media, Hermann, Laura, Lindberg, Amanda, Heuchel, Rainer L., Martin-Bernabe, Alfonso, Dhanjal, Soniya, Navis, Anna C., Villard, Christina, del Valle, Andrea C., Bozoky, Lorand, Sparrelid, Ernesto, Dirix, Luc, Strell, Carina, Östman, Arne, Schmierer, Bernhard, Vermeulen, Peter B., Engstrand, Jennie, Bozoky, Bela, Gerling, Marco, Moro, Carlos Fernandez, Geyer, Natalie, Harrizi, Sara, Hamidi, Yousra, Söderqvist, Sara, Kuznyecov, Danyil, Tidholm Qvist, Evelina, Salmonson Schaad, Media, Hermann, Laura, Lindberg, Amanda, Heuchel, Rainer L., Martin-Bernabe, Alfonso, Dhanjal, Soniya, Navis, Anna C., Villard, Christina, del Valle, Andrea C., Bozoky, Lorand, Sparrelid, Ernesto, Dirix, Luc, Strell, Carina, Östman, Arne, Schmierer, Bernhard, Vermeulen, Peter B., Engstrand, Jennie, Bozoky, Bela, and Gerling, Marco

Abstract

A perimetastatic capsule is a strong positive prognostic factor in liver metastases, but its origin remains unclear. Here, we systematically quantify the capsule's extent and cellular composition in 263 patients with colorectal cancer liver metastases to investigate its clinical significance and origin. We show that survival improves proportionally with increasing encapsulation and decreasing tumor-hepatocyte contact. Immunostaining reveals the gradual zonation of the capsule, transitioning from benign-like NGFR(high) stroma at the liver edge to FAP(high) stroma towards the tumor. Encapsulation correlates with decreased tumor viability and preoperative chemotherapy. In mice, chemotherapy and tumor cell ablation induce capsule formation. Our results suggest that encapsulation develops where tumor invasion into the liver plates stalls, representing a reparative process rather than tumor-induced desmoplasia. We propose a model of metastases growth, where the efficient tumor colonization of the liver parenchyma and a reparative liver injury reaction are opposing determinants of metastasis aggressiveness.

Published
2023
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41. Histopathological growth patterns and tumor-infiltrating lymphocytes in breast cancer liver metastases.

Author

Leduc, Sophia, De Schepper, Maxim, Richard, François, Maetens, Marion, Pabba, Anirudh, Borremans, Kristien, Jaekers, Joris, Latacz, Emily, Zels, Gitte, Bohlok, Ali, Van Baelen, Karen, Nguyen, Ha Linh, Geukens, Tatjana, Dirix, Luc Y, Larsimont, Denis, Vankerckhove, Sophie, Santos, Eva, Oliveira, Rui Caetano, Dede, Kristòf, Kulka, Janina, Borbala, Székely, Salamon, Ferenc, Madaras, Lilla, Marcell Szasz, A, Lucidi, Valerio, Meyer, Yannick Y.M., Topal, Baki, Verhoef, Cornelis, Engstrand, Jennie, Moro, Carlos Fernandez, Gerling, Marco, Bachir, Imane, Biganzoli, Elia, Donckier De Donceel, Vincent, Floris, Giuseppe, Vermeulen, Peter B., Desmedt, Christine, Leduc, Sophia, De Schepper, Maxim, Richard, François, Maetens, Marion, Pabba, Anirudh, Borremans, Kristien, Jaekers, Joris, Latacz, Emily, Zels, Gitte, Bohlok, Ali, Van Baelen, Karen, Nguyen, Ha Linh, Geukens, Tatjana, Dirix, Luc Y, Larsimont, Denis, Vankerckhove, Sophie, Santos, Eva, Oliveira, Rui Caetano, Dede, Kristòf, Kulka, Janina, Borbala, Székely, Salamon, Ferenc, Madaras, Lilla, Marcell Szasz, A, Lucidi, Valerio, Meyer, Yannick Y.M., Topal, Baki, Verhoef, Cornelis, Engstrand, Jennie, Moro, Carlos Fernandez, Gerling, Marco, Bachir, Imane, Biganzoli, Elia, Donckier De Donceel, Vincent, Floris, Giuseppe, Vermeulen, Peter B., and Desmedt, Christine

Abstract

Liver is the third most common organ for breast cancer (BC) metastasis. Two main histopathological growth patterns (HGP) exist in liver metastases (LM): desmoplastic and replacement. Although a reduced immunotherapy efficacy is reported in patients with LM, tumor-infiltrating lymphocytes (TIL) have not yet been investigated in BCLM. Here, we evaluate the distribution of the HGP and TIL in BCLM, and their association with clinicopathological variables and survival. We collect samples from surgically resected BCLM (n = 133 patients, 568 H&E sections) and post-mortem derived BCLM (n = 23 patients, 97 H&E sections). HGP is assessed as the proportion of tumor liver interface and categorized as pure-replacement ('pure r-HGP') or any-desmoplastic ('any d-HGP'). We score the TIL according to LM-specific guidelines. Associations with progression-free (PFS) and overall survival (OS) are assessed using Cox regressions. We observe a higher prevalence of 'any d-HGP' (56%) in the surgical samples and a higher prevalence of 'pure r-HGP' (83%) in the post-mortem samples. In the surgical cohort, no evidence of the association between HGP and clinicopathological characteristics is observed except with the laterality of the primary tumor (p value = 0.049) and the systemic preoperative treatment before liver surgery (p value = .039). TIL is less prevalent in 'pure r-HGP' as compared to 'any d-HGP' (p value = 0.001). 'Pure r-HGP' predicts worse PFS (HR: 2.65; CI: (1.45-4.82); p value = 0.001) and OS (HR: 3.10; CI: (1.29-7.46); p value = 0.011) in the multivariable analyses. To conclude, we demonstrate that BCLM with a 'pure r-HGP' is associated with less TIL and with the worse outcome when compared with BCLM with 'any d-HGP'. These findings suggest that HGP could be considered to refine treatment approaches., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2023

42. The Prognostic Value of Distinct Histological Growth Patterns of Colorectal Peritoneal Metastases: A Pilot Study.

Author

El Asmar, Antoine, Demetter, Pieter, Fares, Fahd, Sclafani, Francesco, Hendlisz, Alain, Donckier De Donceel, Vincent, Vermeulen, Peter B., Liberale, Gabriel, El Asmar, Antoine, Demetter, Pieter, Fares, Fahd, Sclafani, Francesco, Hendlisz, Alain, Donckier De Donceel, Vincent, Vermeulen, Peter B., and Liberale, Gabriel

Abstract

Different histological growth patterns (HGP) describing the tumor-to-liver interface have been described in colorectal liver metastases and have been associated with a strong prognostic value. However, HGP of peritoneal metastases (PM) of colorectal cancer (CRC) have not yet been described. Our objective was to determine whether distinct HGP can be identified in PMCRC and to evaluate their potential prognostic value in these patients., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2023

43. Association of body mass index with clinicopathological features and survival in patients with primary invasive lobular breast cancer

Author

Van Baelen, Karen, Nguyen, Ha Linh, Hamy-Petit, Anne Sophie, Richard, François, Karsten, Maria Margarete, Marta, Guilherme Nader, Vermeulen, Peter B., Toussaint, Aullene, Reyal, F., Vincent-Salomon, A., Dirix, Luc Y, Dordevic, Adam David, de Azambuja, Evandro, Larsimont, Denis, Amato, Ottavia, Maetens, Marion M., De Schepper, Maxim, Geukens, Tatjana, Han, Sileny, Baert, Thaïs, Punie, Kevin, Wildiers, Hans, Smeets, Ann, Nevelsteen, Ines, Floris, Giuseppe, Biganzoli, Elia, Neven, Patrick, Desmedt, Christine, Van Baelen, Karen, Nguyen, Ha Linh, Hamy-Petit, Anne Sophie, Richard, François, Karsten, Maria Margarete, Marta, Guilherme Nader, Vermeulen, Peter B., Toussaint, Aullene, Reyal, F., Vincent-Salomon, A., Dirix, Luc Y, Dordevic, Adam David, de Azambuja, Evandro, Larsimont, Denis, Amato, Ottavia, Maetens, Marion M., De Schepper, Maxim, Geukens, Tatjana, Han, Sileny, Baert, Thaïs, Punie, Kevin, Wildiers, Hans, Smeets, Ann, Nevelsteen, Ines, Floris, Giuseppe, Biganzoli, Elia, Neven, Patrick, and Desmedt, Christine

Abstract

Purpose: Invasive lobular carcinoma (ILC) represents up to 15% of all breast carcinomas. While the proportion of women with overweight and obesity increases globally, the impact of body mass index (BMI) at primary diagnosis on clinicopathological features of ILC and the prognosis of the patients has not been investigated yet. Patients and methods: We performed a multicentric retrospective study including patients diagnosed with non-metastatic pure ILC. The association of BMI at diagnosis with clinicopathological variables was assessed using linear or multinomial logistic regression. Univariable and multivariable survival analyses were performed to evaluate the association of BMI with disease-free survival (DFS), distant recurrence-free survival (DRFS), and overall survival (OS). Results: The data of 2856 patients with ILC and available BMI at diagnosis were collected, of which 2570/2856 (90.0%) had oestrogen receptor (ER)-positive and human epidermal growth factor receptor (HER2) not amplified/overexpressed (ER+/HER2−) ILC. Of these 2570 patients, 80 were underweight (3.1%), 1410 were lean (54.9%), 712 were overweight (27.7%), and 368 were obese (14.3%). Older age at diagnosis, a higher tumour grade, a larger tumour size, a nodal involvement, and multifocality were associated with a higher BMI. In univariable models, higher BMI was associated with worse outcomes for all end-points (DFS: hazard ratio (HR) 1.21, 95CI 1.12–1.31, p value < 0.01; DRFS: HR 1.25, 95CI 1.12–1.40, p value < 0.01; OS: HR 1.25, 95CI 1.13–1.37, p value < 0.01). This association was not statistically significant in multivariable analyses (DFS: HR 1.09, 95CI 0.99–1.20, p value 0.08; DRFS: HR 1.03, 95CI 0.89–1.20, p value 0.67; OS: HR 1.11, 95CI 0.99–1.24, p value 0.08), whereas grade, tumour size, and nodal involvement were still prognostic for all end-points. Conclusion: Worse prognostic factors such as higher grade, larger tumour size, and nodal involvement are associated with higher BMI in ER+, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2023

44. Histopathological growth patterns of neuroendocrine tumor liver metastases

Author

Meyer, Yannick Y.M., Bohlok, Ali, Olthof, Pim P.B., Donckier De Donceel, Vincent, Doukas, Michail, Lucidi, Valerio, Vermeulen, Peter B., Grünhagen, Dirk Jan, Verhoef, Cornelis (Kees) C., Meyer, Yannick Y.M., Bohlok, Ali, Olthof, Pim P.B., Donckier De Donceel, Vincent, Doukas, Michail, Lucidi, Valerio, Vermeulen, Peter B., Grünhagen, Dirk Jan, and Verhoef, Cornelis (Kees) C.

Abstract

Histopathological growth patterns (HGPs) of liver metastases represent a potential biomarker for prognosis after resection. They have never been studied in neuroendocrine tumor liver metastases (NETLM). This study evaluated if distinct HGPs can be observed in resected NETLM and if they have prognostic value. Sixty-three patients who underwent resection of NETLM between 01–01-2001 and 31–12-2021 were retrospectively included. HGPs were scored on Haematoxylin&Eosin slides using light microscopy, distinguishing desmoplastic- (dHGP), pushing- (pHGP) and replacement HGP (rHGP). Average HGP scores were calculated per patient. Each patient was classified according to predominant HGP. Overall and Disease-Free Survival (OS and DFS) were evaluated through Kaplan–Meier analysis and Cox regression. Eighteen patients had predominant dHGP (29%), 33 had predominant pHGP (52%) and 11 had predominant rHGP (17%). One patient had mixed HGP (2%). Five-year OS was 76% (95%CI: 66–87%) for the overall cohort. Five-year OS was 92% (95%CI: 77–100%) for dHGP, was 73% (95%CI: 59–91%) for pHGP, 50% (95%CI: 25–100%) for rHGP. Five-year DFS was 39% (95%CI: 19–83%) for dHGP, 44% (95%CI: 27–71%) for rHGP and 50% (95%CI: 23–100%) for pHGP. There was no significant association between HGP and OS or DFS in multivariable analysis. Distinct HGPs could be identified in NETLM. In patients who underwent resection of NETLM, no association was found between HGPs and postoperative survival. Half of the patients with NETLM have a predominant pushing growth pattern, which is a rare growth pattern in liver metastases from breast and colorectal cancer., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2023

46. Generation of vessel co-option lung metastases mouse models for single-cell isolation of metastases-derived cells and endothelial cells

Author

Cuypers, Anne, primary, Teuwen, Laure-Anne, additional, Bridgeman, Victoria L., additional, de Rooij, Laura P.M.H., additional, Eelen, Guy, additional, Dewerchin, Mieke, additional, Cantelmo, Anna Rita, additional, Kalucka, Joanna, additional, Bouché, Ann, additional, Vinckier, Stefan, additional, Carton, An, additional, Manderveld, Ann, additional, Vermeulen, Peter B., additional, Reynolds, Andrew R., additional, and Carmeliet, Peter, additional

Published
2022
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47. Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases

Author

Frentzas, Sophia, Simoneau, Eve, Bridgeman, Victoria L, Vermeulen, Peter B, Foo, Shane, Kostaras, Eleftherios, Nathan, Mark R, Wotherspoon, Andrew, Gao, Zu-hua, Shi, Yu, Van den Eynden, Gert, Daley, Frances, Peckitt, Clare, Tan, Xianming, Salman, Ayat, Lazaris, Anthoula, Gazinska, Patrycja, Berg, Tracy J, Eltahir, Zak, Ritsma, Laila, van Rheenen, Jacco, Khashper, Alla, Brown, Gina, Nyström, Hanna, Sund, Malin, Van Laere, Steven, Loyer, Evelyne, Dirix, Luc, Cunningham, David, Metrakos, Peter, and Reynolds, Andrew R

Subjects
Angiogenesis inhibitors -- Patient outcomes, Liver cancer -- Drug therapy, Cancer metastasis -- Drug therapy, Biological sciences, Health
Abstract

The efficacy of angiogenesis inhibitors in cancer is limited by resistance mechanisms that are poorly understood. Notably, instead of through the induction of angiogenesis, tumor vascularization can occur through the nonangiogenic mechanism of vessel co-option. Here we show that vessel co-option is associated with a poor response to the anti-angiogenic agent bevacizumab in patients with colorectal cancer liver metastases. Moreover, we find that vessel co-option is also prevalent in human breast cancer liver metastases, a setting in which results with anti-angiogenic therapy have been disappointing. In preclinical mechanistic studies, we found that cancer cell motility mediated by the actin-related protein 2/3 complex (Arp2/3) is required for vessel co-option in liver metastases in vivo and that, in this setting, combined inhibition of angiogenesis and vessel co-option is more effective than the inhibition of angiogenesis alone. Vessel co-option is therefore a clinically relevant mechanism of resistance to anti-angiogenic therapy and combined inhibition of angiogenesis and vessel co-option might be a warranted therapeutic strategy., Author(s): Sophia Frentzas [1, 2]; Eve Simoneau [3]; Victoria L Bridgeman [1]; Peter B Vermeulen [1, 4]; Shane Foo [1]; Eleftherios Kostaras [1]; Mark R Nathan [1]; Andrew Wotherspoon [2]; [...]

Published
2016
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50. An idiosyncratic, zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver

Author

Fernández Moro, Carlos, primary, Harrizi, Sara, additional, Hamidi, Yousra, additional, Geyer, Natalie, additional, Kuznyecov, Danyil, additional, Tidholm-Qvist, Evelina, additional, Salmonson Schaad, Media, additional, del Valle, Andrea C., additional, Söderqvist, Sara, additional, Bozóky, Lorand, additional, Sparrelid, Ernesto, additional, Dirix, Luc, additional, Vermeulen, Peter B, additional, Bozóky, Béla, additional, Engstrand, Jennie, additional, and Gerling, Marco, additional

Published
2022
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