30 results on '"Verkauskienė R"'
Search Results
2. Emotional state, cognitive functioning and quality of life of adult women with Turner syndrome in Lithuania
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Lašaitė, L., Krikščiūnienė, R., Žilaitienė, B., and Verkauskienė, R.
- Published
- 2019
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3. Agreement of different methods for assessment of progesterone concentrations in beef cattle serum
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Rekešiūtė, A., primary, Januškauskas, A., additional, Šiukščius, A., additional, Riškevičienė, V., additional, Vitkauskienė, A., additional, Verkauskienė, R., additional, Antanaitis, R., additional, and Žilinskas, H., additional
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- 2023
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4. Agreement of different methods for assessment of progesterone concentrations in beef cattle serum
- Author
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Rekešiūtė, A., Januškauskas, A., Šiukščius, A., Riškevičienė, V., Vitkauskienė, A., Verkauskienė, R., Antanaitis, R., and Žilinskas, Henrikas
- Subjects
agreement ,confidence interval ,assessment methods ,progesterone ,sample extraction ,ELISA ,RIA - Abstract
Progesterone (P4) is responsible for the main reproduction processes. Concentration of P4 varies widely among different determination methods, and interpretation of these values may be difficult. The objective of the current study was to assess the agreement of three different enzyme immunoassays (ELISA) in relation to radioimmunoassay (RIA) of P4 concentration assessment of beef cow serum samples. Samples were collected randomly considering high (pregnant cows) and low (non-pregnant cows) P4 concentrations. Depending on the P4 assessment method, four groups were created as follows: Group 1 – direct samples assessed by ELISA, Group 2 – extracted samples assessed by ELISA, Group 3 – samples assessed by automated ELISA, and Group 4 – samples assessed by RIA. The mean progesterone concentration was 4.50 ng/mL, 1.24 ng/mL, 4.07 ng/mL and 4.39 ng/mL from Group 1 to Group 4, respectively. The mean difference (MD) between Group 1, Group 2 and Group 3 individually compared with Group 4 was −0.10 ± 1.24 ng/mL, 3.15 ± 3.58 ng/mL and 0.33 ± 1.42 ng/mL, and the 95% confidence interval (CI) for the differences (s) was from −0.99 to 0.78 ng/mL, from 0.59 to 5.71 ng/mL, and from −0.69 to 1.34 ng/mL, respectively. The confidence interval for the lower and upper limit of the agreement ranged from −4.12 to −1.05 ng/mL and from 0.84 to 3.91 ng/mL between Group 1 and Group 4, from −8.45 to 0.42 ng/ mL and from 5.88 to 14.75 ng/mL between Group 2 and Group 4, from −4.29 to −0.76 ng/mL, and from 1.41 to 4.94 ng/mL between Group 3 and Group 4. Our findings show that the best agreement with RIA was observed for Group 1 and Group 3, while the agreement in the extraction method was least accurate.
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- 2019
5. 286 Masturbation of Healthy and Type 1 Diabetics Males Using the European Male Ageing Study Sexual Function Questionnaire
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Tribusauskaite, S., Matuleviciute, I., Banisauskaite, I., Urbanavicius, V., Verkauskiene, R., and Matulevicius, V.
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- 2017
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6. P.1.l.008 - Associations between depressive and anxiety symptoms severity and decline in cognitive domains among patients with type 2 diabetes without dementia: cross-sectional study
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Audaraitė, V., Lukosiute, D., Verkauskiene, R., Adomaitiene, V., and Steibliene, V.
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- 2016
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7. HP-02-005 Sexual function in women with Turner syndrome in Lithuanian population
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Kriksciuniene, R., Zilaitiene, B., Sematonyte, J., and Verkauskiene, R.
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- 2016
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8. PS-05-009 Influences of hormone-based contraception on female sexual function
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Ciaplinskiene, L., Zilaitiene, B., Verkauskiene, R., Zalinkevicius, R., Bumbuliene, Z., Vanagiene, V., Pagareckaite, M., and Johannes, B.
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- 2016
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9. P-06-010 Sexual function in women with Turner syndrome in Lithuanian population
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Kriksciuniene, R., Sematonyte, J., Zilaitiene, B., and Verkauskiene, R.
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- 2016
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10. P-01-058 Evaluation of sexuality between 26-36-year-old healthy and type 1 diabetic men using European male ageing study sexual functioning questionnaire
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Kurakovas, T., Matuleviciute, I., Banisauskaite, I., Jureviciute, J., Galkine, A., Urbanavicius, V., Matulevicius, V., Ostrauskas, R., and Verkauskiene, R.
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- 2016
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11. O64 Relation entre l’environnement intra utérin et l’insulinémie à la naissance dans une cohorte prospective de nouveau-nés
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Beltrand, J., Nicolescu, R., Verkauskiene, R., Deghmoun, S., Claris, O., Gaucherand, P., Sibony, O., and Lévy-Marchal, C.
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- 2008
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12. The Association of Thyroid Disease with Risk of Dementia and Cognitive Impairment: A Systematic Review.
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Alšauskė SV, Liseckienė I, and Verkauskienė R
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- Humans, Risk Factors, Hypothyroidism complications, Hypothyroidism physiopathology, Dementia etiology, Dementia complications, Cognitive Dysfunction etiology, Cognitive Dysfunction physiopathology, Thyroid Diseases complications, Thyroid Diseases physiopathology
- Abstract
Background and Objectives : Cognitive impairment is defined as a reduced ability to perform one or more cognitive functions, potentially leading to dementia if the condition worsens. With dementia being a rapidly growing public health issue affecting approximately 50 million people worldwide, understanding modifiable risk factors such as thyroid disease is crucial for prevention and early diagnosis. Thyroid hormones play a vital role in brain development and functioning, impacting processes such as neuron growth, myelination, and neurotransmitter synthesis. Recent decades have seen thyroid disorders emerging as potential independent risk factors for reversible cognitive impairment. Materials and Methods : The review adheres to PRISMA guidelines, utilizing a structured PICO question to explore whether individuals with thyroid diseases have a higher risk of developing dementia and cognitive impairments compared to those without. The literature search was conducted in PubMed, Cochrane, and ScienceDirect databases, including studies published from 1 January 2019 to 31 December 2023. The literature review discusses nine selected articles. Results : The findings highlight a complex association between thyroid dysfunction and cognitive decline, with some studies indicating significant links, particularly with hypothyroidism, and others suggesting the relationship may depend on the specific type of thyroid dysfunction or cognitive domain affected. Six out of nine articles found a link between thyroid disease and cognitive impairment, while three articles refuted this link. Conclusions : The review reveals a complex and ambiguous relationship between thyroid dysfunction and cognitive impairment. Further research is needed to elucidate the mechanisms underlying these associations and to determine whether thyroid dysfunction may be a modifiable risk factor for dementia.
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- 2024
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13. Impact of Nutrient Intake on Body Composition in Very Low-Birth Weight Infants Following Early Progressive Enteral Feeding.
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Brinkis R, Albertsson-Wikland K, Šmigelskas K, Vanckavičienė A, Aldakauskienė I, Tamelienė R, and Verkauskienė R
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- Humans, Female, Male, Infant, Newborn, Gestational Age, Adiposity, Infant, Premature growth & development, Infant, Nutrients, Absorptiometry, Photon, Infant, Extremely Premature, Energy Intake, Food, Fortified, Skinfold Thickness, Enteral Nutrition methods, Infant, Very Low Birth Weight growth & development, Body Composition, Infant Nutritional Physiological Phenomena
- Abstract
Preterm infants have increased body adiposity at term-equivalent age and risk of adverse metabolic outcomes. The aim of the study was to define how nutrient intake may impact body composition (BC) of very low-birth weight infants fed with early progressive enteral feeding and standard fortification. Eighty-six infants with <1500 g birth weight were included in the BC study and stratified into extremely preterm (EP) and very preterm (VP) groups. Nutrient intake was calculated during the first 28 days and BC assessed by dual X-ray absorptiometry at discharge and by skinfold thickness at 12 months of corrected age (CA). Total nutrient intake did not differ between the groups. EP infants had a higher fat mass percentage at discharge than VP infants (24.8% vs. 19.4%, p < 0.001); lean mass did not differ. None of the nutrients had any impact on BC of EP infants. Protein intake did not result in a higher lean mass in either group; fat intake was a significant predictor of increased fat mass percentage in VP infants at discharge ( p = 0.007) and body adiposity at 12 months of CA ( p = 0.021). Nutritional needs may depend on gestational age and routine fortification should be used with caution in more mature infants.
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- 2024
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14. Impact of Early Nutrient Intake and First Year Growth on Neurodevelopment of Very Low Birth Weight Newborns.
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Brinkis R, Albertsson-Wikland K, Tamelienė R, Aldakauskienė I, Rimdeikienė I, Marmienė V, Šmigelskas K, and Verkauskienė R
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- Carbohydrates, Eating, Humans, Infant, Infant Nutritional Physiological Phenomena, Infant, Newborn, Infant, Very Low Birth Weight, Patient Discharge, Aftercare, Infant, Premature
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Optimal nutrient intake ensuring better neurodevelopment for very low birth weight (VLBW) infants remains unknown. The aim of this study was to assess the relationship between early (first 28 days) nutritional intake, first year growth, and neurodevelopment. In total, 120 VLBW infants were included into the study. A group of 95 infants completed follow-up to 12 months of corrected gestational age (CGA). Nutrient intake was assessed, and weight, length, and head circumference (HC) were measured weekly until discharge and at 3, 6, 9, and 12 months of CGA. Neurodevelopment was assessed at 12 months of CGA. Two groups-extremely preterm (EP) and very/moderately preterm (VP)-were compared. Growth before discharge was slower in the EP group than the VP group. At 12 months, there was no difference in anthropometric characteristics or neurodevelopmental scores between the groups. Higher carbohydrate intake during the first 28 days was the single significant predictor for better cognitive scores only in the EP group (β
s = 0.60, p = 0.017). Other nutrients and growth before discharge were not significant for cognitive and motor scores in either group in multivariable models, whereas post-discharge HC growth was associated with both cognitive and motor scores in the VP group. Monitoring intake of all nutrients and both pre-discharge and post-discharge growth is essential for gaining knowledge about individualized nutrition for optimal neurodevelopment.- Published
- 2022
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15. Reply to Manzar, S. Comment on "Brinkis et al. Nutrient Intake with Early Progressive Enteral Feeding and Growth of Very Low-Birth-Weight Newborns. Nutrients 2022, 14 , 1181".
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Brinkis R, Albertsson-Wikland K, Tamelienė R, Vinskaitė A, Šmigelskas K, and Verkauskienė R
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- Eating, Humans, Infant, Newborn, Infant, Very Low Birth Weight, Nutrients, Enteral Nutrition, Infant, Premature
- Abstract
We appreciate Dr. Shabih Manzar's interest [...].
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- 2022
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16. Nutrient Intake with Early Progressive Enteral Feeding and Growth of Very Low-Birth-Weight Newborns.
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Brinkis R, Albertsson-Wikland K, Tamelienė R, Vinskaitė A, Šmigelskas K, and Verkauskienė R
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- Eating, Energy Intake, Humans, Infant, Infant, Newborn, Infant, Very Low Birth Weight, Enteral Nutrition, Infant, Premature
- Abstract
Early nutrition is one of the most modifiable factors influencing postnatal growth. Optimal nutrient intakes for very preterm infants remain unknown, and poor postnatal growth is common in this population. The aim of this study was to assess nutrient intake during the first 4 weeks of life with early progressive enteral feeding and its impact on the in-hospital growth of very low-birth-weight (VLBW) infants. In total, 120 infants with birth weights below 1500 g and gestational ages below 35 weeks were included in the study. Nutrient intakes were assessed daily for the first 28 days. Growth was measured weekly until discharge. Median time of parenteral nutrition support was 6 days. Target enteral nutrient and energy intake were reached at day 10 of life, and remained stable until day 28, with slowly declining protein intake. Median z-scores at discharge were -0.73, -0.49, and -0.31 for weight, length, and head circumference, respectively. Extrauterine growth restriction was observed in 30.3% of the whole cohort. Protein, carbohydrates, and energy intakes correlated positively with weight gain and head circumference growth. Early progressive enteral feeding with human milk is well tolerated in VLBW infants. Target enteral nutrient intake may be reached early and improve in-hospital growth.
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- 2022
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17. Impact of Newborn Screening on Clinical Presentation of Congenital Adrenal Hyperplasia.
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Navardauskaitė R, Banevičiūtė K, Songailienė J, Grigalionienė K, Čereškevičius D, Šukys M, Mockevicienė G, Smirnova M, Utkus A, and Verkauskienė R
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- Birth Weight, Humans, Infant, Infant, Newborn, Male, Neonatal Screening, Retrospective Studies, Sensitivity and Specificity, Adrenal Hyperplasia, Congenital diagnosis, Adrenal Hyperplasia, Congenital epidemiology
- Abstract
Background and Objectives : The main reason for Newborn screening (NBS) for congenital adrenal hyperplasia (CAH) is to prevent adrenal insufficiency that can lead to life-threatening conditions. On the other hand, screening programs are not always sensitive and effective enough to detect the disease. We aimed to evaluate impact of the national NBS on the clinical presentation of patients with CAH in Lithuania. Materials and Methods : A retrospective study was performed on data of 88 patients with CAH from 1989 to 2020. Patients with confirmed CAH were divided into two groups: (1) 75 patients diagnosed before NBS: 52 cases with salt-wasting (SW), 21 with simple virilising (SV) and two with non-classical (NC) form; (2) 13 patients diagnosed with NBS: 12 cases with SW and 1 case with SV form. For the evaluation of NBS effectiveness, data of only male infants with salt-wasting CAH were analysed ( n = 36, 25 unscreened and nine screened). Data on gestational age, birth weight, weight, symptoms, and laboratory tests (serum potassium and sodium levels) on the day of diagnosis, were analysed. Results : A total of 158,486 neonates were screened for CAH from 2015 to 2020 in Lithuania and CAH was confirmed in 13 patients (12 SW, one-SV form), no false negative cases were found. The sensitivity and specificity of NBS program for classical CAH forms were 100%; however, positive predictive value was only 4%. There were no significant differences between unscreened and screened male infant groups in terms of age at diagnosis, serum potassium, and serum sodium levels. Significant differences were found in weight at diagnosis between the groups (-1.67 ± 1.12 SDS versus 0.046 ± 1.01 SDS of unscreened and screened patients respectively, p = 0.001). Conclusions : The sensitivity and specificity of NBS for CAH program were 100%, but positive predictive value-only 4%. Weight loss was significantly lower and the weight SDS at diagnosis was significantly higher in the group of screened patients.
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- 2021
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18. Papillary Thyroid Carcinoma Tissue miR-146b, -21, -221, -222, -181b Expression in Relation with Clinicopathological Features.
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Kondrotienė A, Daukša A, Pamedytytė D, Kazokaitė M, Žvirblienė A, Daukšienė D, Simanavičienė V, Klimaitė R, Golubickaitė I, Stakaitis R, Šarauskas V, Verkauskienė R, and Žilaitienė B
- Abstract
We analyzed miR-146b, miR-21, miR-221, miR-21, and miR-181b in formalin fixed paraffin-embedded papillary thyroid carcinoma (PTC) tissue samples of 312 individuals and evaluated their expression relationship with clinicopathological parameters. A higher expression of miR-21 was related to unifocal lesions ( p < 0.011) and autoimmune thyroiditis (0.007). miR-221, miR-222 expression was higher in the PTC tissue samples with extrathyroidal extension ( p = 0.049, 0.003, respectively). In a group of PTC patients with pT1a and pT1b sized tumors, the expression of miR-146b, miR-21, miR-221, and miR-222 in PTC tissue samples was lower than in patients with pT2, pT3, and pT4 ( p = 0.032; 0.0044; 0.003; 0.001; 0.001, respectively). Patients with lymph node metastases had higher expression of miR-21, -221, -222, and -181b ( p < 0.05). A high expression of miR-146b, miR-21, miR-221 panel was associated with decreased overall survival (OS) (Log rank p = 0.019). Univariate analysis revealed that presence of metastatic lymph nodes and high expression of miR-146b, miR-21, and miR-221 panels were associated with increased hazard of shorter OS. After multivariate analysis, only sex (male) and age (≥55 years) emerged as independent prognostic factors associated with shorter OS (HR 0.28 (95% CI 0.09-0.86) and HR 0.05 (95% CI 0.01-0.22), respectively). In conclusion, 5 analyzed miRs expression have significant relations to clinicopathologic parameters so further investigations of these molecules are expedient while searching for prognostic PTC biomarkers.
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- 2021
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19. Prevalence of Metabolic Syndrome and Impaired Glucose Metabolism among 10- to 17-Year-Old Overweight and Obese Lithuanian Children and Adolescents.
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Smetanina N, Valickas R, Vitkauskiene A, Albertsson-Wikland K, and Verkauskienė R
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- Adolescent, Adult, Blood Glucose, Body Mass Index, Child, Humans, Obesity epidemiology, Overweight epidemiology, Prevalence, Diabetes Mellitus, Type 2 epidemiology, Insulin Resistance, Metabolic Syndrome epidemiology
- Abstract
Background: Overweight (Ow) and obesity among adults and children increases the risk of metabolic consequences. Metabolic syndrome (MS) and impaired glucose metabolism are well-known risk factors for cardiovascular diseases and type 2 diabetes. The aim of this study was to evaluate the prevalence of MS and impaired glucose metabolism among Ow and obese (Ob) children and adolescents (aged 10-17 years) in Lithuania, and to evaluate the associations between insulin resistance (IR) indices and anthropometric parameters as well as metabolic disturbances., Methods: The study population consisted of 344 OwOb children and adolescents of all pubertal stages. Oral glucose tolerance tests (OGTTs), IR and β cell function indices, lipid profile, and anthropometric parameters of all subjects were analyzed. MS was defined according to the International Diabetes Federation consensus guidelines., Results: MS was found in 21.3% of the OwOb children and adolescents, and 12.1% had impaired glucose metabolism (6.9% with impaired fasting glucose, 4.5% with impaired glucose tolerance, and 0.6% with type 2 diabetes). IR was directly related to body mass index and waist circumference, waist-to-height and waist-to-hip ratios, and sum of skin-fold thicknesses. Children with MS were more insulin-resistant, had higher odds ratio for prediabetes and had a more disturbed lipid profile than subjects without MS. Moreover, total cholesterol and low-density lipoprotein cholesterol levels were significantly lower in the more mature OwOb adolescents., Conclusion: MS and lipid profile disturbances are common in OwOb children and adolescents. MS is directly associated with IR. Therefore, OwOb children and adolescents should be carefully followed up for metabolic abnormalities during late childhood as these can persist into adulthood., (© 2021 The Author(s) Published by S. Karger AG, Basel.)
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- 2021
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20. Plasma-Derived miRNA-222 as a Candidate Marker for Papillary Thyroid Cancer.
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Kondrotienė A, Daukša A, Pamedytytė D, Kazokaitė M, Žvirblienė A, Daukšienė D, Simanavičienė V, Klimaitė R, Golubickaitė I, Stakaitis R, Šarauskas V, Verkauskienė R, and Žilaitienė B
- Subjects
- Biomarkers, Tumor blood, Carcinoma, Papillary blood, Carcinoma, Papillary genetics, Carcinoma, Papillary surgery, Case-Control Studies, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Male, MicroRNAs blood, Middle Aged, ROC Curve, Thyroid Neoplasms blood, Thyroid Neoplasms genetics, Thyroid Neoplasms surgery, Biomarkers, Tumor genetics, Carcinoma, Papillary diagnosis, MicroRNAs genetics, Thyroid Neoplasms diagnosis
- Abstract
We analyzed five miRNA molecules (miR-221; miR-222; miR-146b; miR-21; miR-181b) in the plasma of patients with papillary thyroid cancer (PTC), nodular goiter (NG) and healthy controls (HC) and evaluated their diagnostic value for differentiation of PTC from NG and HC. Preoperative PTC plasma miRNA expression ( n = 49) was compared with plasma miRNA in the HC group ( n = 57) and patients with NG ( n = 23). It was demonstrated that miR-221; miR-222; miR-146b; miR-21 and miR-181b were overexpressed in preoperative PTC plasma samples compared to HC ( p < 0.0001; p < 0.0001; p < 0.0001; p < 0.0001; p < 0.002; respectively). The upregulation in tumor tissue of these miRNAs was consistent with The Cancer Genome Atlas Thyroid Carcinoma dataset. A significant decrease in miR-21; miR-221; miR-146b and miR-181b expression was observed in the plasma of PTC patients after total thyroidectomy ( p = 0.004; p = 0.001; p = 0.03; p = 0.036; respectively). The levels of miR-222 were significantly higher in the preoperative PTC compared to the NG group ( p = 0.004). ROC curve (receiver operating characteristic curve) analysis revealed miR-222 as a potential marker in distinguishing PTC from NG (AUC 0.711; p = 0.004). In conclusion; circulating miR-222 profiles might be useful in discriminating PTC from NG.
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- 2020
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21. Agreement of different methods for assessment of progesterone concentrations in beef cattle serum.
- Author
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Rekešiūtė A, Januškauskas A, Šiukščius A, Riškevičienė V, Vitkauskienė A, Verkauskienė R, Antanaitis R, and Žilinskas H
- Subjects
- Animals, Blood Chemical Analysis methods, Female, Blood Chemical Analysis veterinary, Cattle blood, Enzyme-Linked Immunosorbent Assay veterinary, Progesterone blood, Radioimmunoassay veterinary
- Abstract
Progesterone (P4) is responsible for the main reproduction processes. Concentration of P4 varies widely among different determination methods, and interpretation of these values may be difficult. The objective of the current study was to assess the agreement of three different enzyme immunoassays (ELISA) in relation to radioimmunoassay (RIA) of P4 concentration assessment of beef cow serum samples. Samples were collected randomly considering high (pregnant cows) and low (non-pregnant cows) P4 concentrations. Depending on the P4 assessment method, four groups were created as follows: Group 1 - direct samples assessed by ELISA, Group 2 - extracted samples assessed by ELISA, Group 3 - samples assessed by automated ELISA, and Group 4 - samples assessed by RIA. The mean progesterone concentration was 4.50 ng/mL, 1.24 ng/mL, 4.07 ng/mL and 4.39 ng/mL from Group 1 to Group 4, respectively. The mean difference (MD) between Group 1, Group 2 and Group 3 individually compared with Group 4 was -0.10 ± 1.24 ng/mL, 3.15 ± 3.58 ng/mL and 0.33 ± 1.42 ng/mL, and the 95% confidence interval (CI) for the differences (s) was from -0.99 to 0.78 ng/mL, from 0.59 to 5.71 ng/mL, and from -0.69 to 1.34 ng/mL, respectively. The confidence interval for the lower and upper limit of the agreement ranged from -4.12 to -1.05 ng/mL and from 0.84 to 3.91 ng/mL between Group 1 and Group 4, from -8.45 to 0.42 ng/ mL and from 5.88 to 14.75 ng/mL between Group 2 and Group 4, from -4.29 to -0.76 ng/mL, and from 1.41 to 4.94 ng/mL between Group 3 and Group 4. Our findings show that the best agreement with RIA was observed for Group 1 and Group 3, while the agreement in the extraction method was least accurate., (Copyright© by the Polish Academy of Sciences.)
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- 2019
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22. Relationship between Echocardiographic and Magnetic Resonance-Derived Measurements of the Thoracic Aorta in Turner Syndrome Patients.
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Krikščiūnienė R, Navickaitė I, Ereminienė E, Lukoševičius S, Žilaitienė B, and Verkauskienė R
- Abstract
Introduction: Turner syndrome (TS) is assigned to the rare diseases group. Morbidity and mortality of TS patients are high, particularly due to the cardiovascular disorders, so monitoring for cardiovascular complications must be ensured. The data demonstrate a strong correlation between 2-dimensional echocardiographic (2Decho) evaluation and magnetic resonance imaging (MRI); still, according to recent guidelines, MRI remains a gold standard. In this study, we aimed to compare aortic dimensions on MRI and 2Decho in TS patients., Methods: 50 TS patients (≥18 years) were enrolled into the cross-sectional study. 2Decho and MRI were performed. The measurements of the aorta were assessed in five standard positions on 2Decho and in 9 standard positions on MRI; ASI (aortic size index) of the ascending aorta was calculated since reduced adult height is observed in TS patients., Results: ASI on echocardiography strongly correlated with ASI on MRI in all positions of the ascending aorta, but significantly larger medians of ASI were found on 2Decho in all positions of the ascending aorta and arch when compared with MRI measurements. Still, the prevalence of aortic sinus dilation was significantly and more frequently (52% vs. 38%, p < 0.001) observed on MRI when compared with 2Decho., Conclusion: The relation of aortic size was significant in all positions when comparing the MRI and 2Decho methods; still, the dilatation of the sinus of aorta was more frequently found on MRI compared with echocardiography., Competing Interests: The authors declare that there are no conflicts of interest in preparing this article.
- Published
- 2019
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23. Adrenal Function in Adolescence is Related to Intrauterine and Postnatal Growth.
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Petraitienė I, Valūnienė M, Albertsson-Wikland K, and Verkauskienė R
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- Adolescent, Adrenal Glands metabolism, Body Mass Index, Child, Child, Preschool, Cohort Studies, Dehydroepiandrosterone analysis, Dehydroepiandrosterone blood, Female, Humans, Hydrocortisone analysis, Hydrocortisone blood, Infant, Infant, Small for Gestational Age growth & development, Linear Models, Male, Sex Factors, Adrenal Glands enzymology, Fetal Growth Retardation enzymology, Growth and Development physiology
- Abstract
Background and objectives: Intrauterine growth restriction is thought to be implicated in long-term programming of hypothalamic-pituitary-adrenal axis activity. We investigated adrenal function in adolescents born small for gestational age (SGA) in relation to their postnatal growth and cardiovascular parameters. Materials and Methods: Anthropometric parameters, blood pressure, heart rate, dehydroepiandrosterone sulfate (DHEAS), and cortisol levels were assessed in 102 adolescents aged 11-14 years followed from birth (47 SGA and 55 born appropriate for gestational age (AGA)). Results: Mean DHEAS levels were higher in SGA adolescents with catch-up growth (SGA
CU+ ), compared with AGA. Second-year height velocity and body mass index (BMI) gain during preschool years were positively related to DHEAS levels. Morning cortisol levels and systolic and diastolic blood pressure were higher in SGA adolescents without catch-up growth (SGACU - ) compared with AGA. Second-year BMI gain was inversely, and 2-12 years increase in subscapular skinfold thickness was directly associated with cortisol levels. Size at birth and postnatal growth explained 47.8% and 38.2% of variation in DHEAS and cortisol levels, respectively. Conclusion: Adrenal function in adolescence is affected by prenatal and postnatal growth: small size at birth with postnatal catch-up growth is related to higher DHEAS secretion, whereas increased cortisol levels and blood pressure are higher in short SGA adolescents., Competing Interests: All authors have no financial or other conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.- Published
- 2019
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24. Paediatric Endocrinology Subspecialty - The European Map, 55 Years Later.
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Lebl J, Luczay A, Darendeliler F, and Verkauskienė R
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- Europe, Female, History, 20th Century, History, 21st Century, Humans, Male, Endocrinology history, Endocrinology trends, Pediatrics history, Pediatrics trends
- Published
- 2018
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25. Thirty-Five Years of Thyroid Cancer Experience in a Paediatric Population: Incidence Trends in Lithuania between 1980 and 2014.
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Bėrontienė R, Jašinskienė E, Kiudelienė R, Kuprionis G, Makštienė J, Macaitytė R, Marčiulionytė D, Poškienė L, Šemetaitė A, Šidlauskas V, Valickas R, Žalinkevičius R, and Verkauskienė R
- Abstract
Background: Thyroid cancer (TC) is a rare condition in children. It may be associated with radiation, iodine deficiency or familial inheritance., Aims: The objectives of this study were to analyse the prevalence and incidence trends over 3 decades and clinical features of TC in the paediatric population in Lithuania., Methods: We reviewed all TC cases diagnosed in children aged less than 18 years during the period 1980-2014 using medical records from 3 main hospitals in Lithuania where such TC cases are managed., Results: During the 35-year period (1980-2014) there were 57 cases (45 females) of TC in children in Lithuania. The mean age at the time of diagnosis was 14.51 ± 0.52 years. The crude incidence rate of TC ranged from 0 to 0.93 cases per 100,000 children per year and the mean annual increase was 5.26% (p < 0.001). Papillary carcinoma was the most common histological type (73.7%). No association was found between the incidence of TC and the reported areas of radioactive contamination after the Chernobyl accident. In total, 8.8% of patients had secondary TC after initial radiotherapy of a primary oncologic disease., Conclusion: The incidence of TC in the Lithuanian paediatric population between 1980 and 2014 ranged from 0 to 0.93 cases per 100,000 children per year and there was a 5.26% annual increase (p < 0.001), most probably related to the increased use of ultrasound testing.
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- 2017
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26. Diabetes distress in males and females with type 1 diabetes in adolescence and emerging adulthood.
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Lašaitė L, Dobrovolskienė R, Danytė E, Stankutė I, Ražanskaitė-Virbickienė D, Schwitzgebel V, Marčiulionytė D, and Verkauskienė R
- Subjects
- Adolescent, Adult, Chronic Disease psychology, Cross-Sectional Studies, Emotions, Female, Humans, Lithuania, Male, Young Adult, Diabetes Mellitus, Type 1 psychology, Self Care, Stress, Psychological epidemiology
- Abstract
Background: Age and gender are important factors in the adjustment and psychological well-being of patients with chronic physical illness., Aim: To explore the gender and age differences in diabetes distress between adolescents and emerging adults with type 1 diabetes (T1D)., Subjects and Methods: Diabetes distress was compared in 255 adolescents and 283 emerging adults with T1D using Problem Areas in Diabetes scale., Results: High diabetes distress level was found in 22.8% of participants. Lack of confidence in self-care (6.0 vs 3.0, p=0.002), negative emotional consequences (10.0 vs 6.0, p=0.004), and overall score (18.75 vs 11.25, p=0.002) were higher in adult than in adolescent males, when adjusted for age at T1D onset. Negative emotional consequences (13.0 vs 10.0, p=0.005) and overall score (25.0 vs 20.0, p=0.016) were higher in adult compared to adolescent females, when adjusted for age at T1D onset. Lack of confidence in self-care (6.0 vs 3.0, p=0.002), negative emotional consequences (10.0 vs 6.0, p=0.015), and overall score (20.0 vs 11.2, p=0.005) were higher in adolescent females compared to males, when adjusted for age at T1D onset. Negative emotional consequences score was higher in adult females compared to males (13.0 vs 10.0, p=0.029), when adjusted for age at T1D onset. In conclusion, our findings show that patients with T1D have greater burden of diabetes distress in emerging adulthood than in adolescence and add to evidence suggesting the importance of addressing diabetes distress in clinical care and the necessity of wider picture beyond the physical manifestation of diabetes to be taken into consideration., (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
27. The effect of a drospirenone-containing combined oral contraceptive on female sexual function: a prospective randomised study.
- Author
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Čiaplinskienė L, Žilaitienė B, Verkauskienė R, Žalinkevičius R, Bumbulienė Ž, Vanagienė V, and Bitzer J
- Subjects
- Adult, Contraception, Barrier, Female, Humans, Natural Family Planning Methods, Odds Ratio, Risk Factors, Surveys and Questionnaires, Young Adult, Androstenes therapeutic use, Contraceptives, Oral, Combined therapeutic use, Ethinyl Estradiol therapeutic use, Libido, Sexual Dysfunction, Physiological epidemiology, Sexual Dysfunctions, Psychological epidemiology
- Abstract
Objectives: The study investigated the effects on female sexual function of a progestogen-containing combined oral contraceptives (COCs) with an antiandrogenic profile taken in a continuous regimen., Methods: In this prospective randomised single-institution study, 80 healthy women with a monogamous partner and an active sexual life were randomised into two groups for a period of 3 months. Women in the exposed group (n = 40) took a COCs containing 30 μg ethinylestradiol (EE) and 3 mg drospirenone (DRSP) in a 21/7 regimen. Women in the control group (n = 40) used either a barrier contraceptive method (BCM) or a natural family planning method (NFPM). Participants were asked to complete a set of validated questionnaires to assess sociodemographic variables and measure Female Sexual Function Index (FSFI)., Results: The total FSFI score (p < 0.0001), as well as the desire (p = 0.04) and arousal (p = 0.03) scores, were significantly lower in the COCs group after 3 months of hormonal contraceptive use compared with baseline. Women using BCM or NFPM showed an improvement in total FSFI score (p = 0.02). Hormonal contraception with DRSP increased the likelihood of worse sexual function in the desire (odds ratio [OR] 2.47; 95% confidence interval [CI] 1.22, 4.98; p = 0.01) and arousal domains (OR 2.85; 95%CI 1.34, 5.93; p = 0.005) and in total FSFI score (OR 2.01; 95%CI 1.45, 2.79; p < 0.001). The results remained statistically significant even after adjustment for smoking status., Conclusions: The study found evidence that women taking a combined EE/DRSP COCs for 3 months may have a worsening of sexual function as measured by FSFI.
- Published
- 2016
- Full Text
- View/download PDF
28. Congenital hyperinsulinism.
- Author
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Petraitienė I, Barauskas G, Gulbinas A, Malcius D, Hussain K, Verkauskas G, and Verkauskienė R
- Subjects
- Codon, Nonsense, Combined Modality Therapy, Congenital Hyperinsulinism genetics, Humans, Infant, Male, Sulfonylurea Receptors genetics, Treatment Outcome, Congenital Hyperinsulinism diagnosis, Congenital Hyperinsulinism surgery
- Abstract
Hyperinsulinism is the most common cause of hypoglycemia in infants. In many cases conservative treatment is not effective and surgical intervention is required. Differentiation between diffuse and focal forms and localization of focal lesions are the most important issues in preoperative management. We present a case of persistent infancy hyperinsulinism. Clinical presentation, conservative treatment modalities, diagnostic possibilities of focal and diffuse forms, and surgical treatment, which led to total recovery, are discussed., (Copyright © 2014 Lithuanian University of Health Sciences. Production and hosting by Elsevier Urban & Partner Sp. z o.o. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
29. Early development of endocrine and metabolic consequences after treatment of central nervous system tumors in children.
- Author
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Ramanauskienė E, Labanauskas L, Verkauskienė R, and Sileikienė R
- Subjects
- Brain Neoplasms radiotherapy, Brain Neoplasms surgery, Child, Combined Modality Therapy adverse effects, Endocrine System Diseases etiology, Female, Glioma radiotherapy, Glioma surgery, Glioma therapy, Humans, Hydrocortisone deficiency, Hypothyroidism epidemiology, Hypothyroidism etiology, Incidence, Male, Medulloblastoma radiotherapy, Medulloblastoma surgery, Medulloblastoma therapy, Metabolic Diseases etiology, Obesity epidemiology, Obesity etiology, Prevalence, Receptor, IGF Type 1 deficiency, Thyroid Gland physiopathology, Brain Neoplasms therapy, Endocrine System Diseases epidemiology, Metabolic Diseases epidemiology
- Abstract
Background and Objective: Survival after childhood cancer has dramatically improved during last few decades, implying the need for evaluation and correction of late consequences of the disease and its treatment. The aim of this study was to characterize endocrine and metabolic late effects after treatment of brain tumors in children., Materials and Methods: Late complications were analyzed in 51 children treated for brain tumors at the Hospital of Lithuanian University of Health Sciences during 2000-2011. Data on late endocrine and metabolic effects were collected from medical records. Most frequently patients suffered from low-grade glioma (n=17, 33.3%) and medulloblastoma (n=13, 25.5%). The majority (n=42, 82.4%) of the patients underwent surgery; 29 (56.9%) received radiotherapy (RT); 26 (51.0%), chemotherapy; and 17 (33.4%), combined treatment., Results: The median follow-up was 21 months (range 0.25-10.6 years). Most common endocrine consequence was low serum insulin-like growth factor (IGF-I) levels (58.3%), found on average in 30.7 months after cancer treatment. Short stature was observed in 34.6% (mean time to development, 47.7 months), and hypothyroidism in 40.7% of patients (mean time to development, 63.6 months). Low bone mineral density was found in 50.0% of the cases after 44.5 months and overweight in 30.0% after 49.9 months of follow-up., Conclusions: Survivors of brain tumors suffer from numerous endocrine and metabolic consequences, majority of them developing within the first 5 years after brain tumor therapy. An active follow-up aiming for early diagnosis and therapy is essential for improvement of quality of life in these patients., (Copyright © 2014 Lithuanian University of Health Sciences. Production and hosting by Elsevier Urban & Partner Sp. z o.o. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
30. Carcinoma of two parathyroid glands caused by a novel MEN1 gene mutation - a rare feature of the MEN 1 syndrome.
- Author
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Juodelė L, Serapinas D, Sabaliauskas G, Krasauskienė A, Krasauskas V, Verkauskienė R, Barkauskienė D, and Juozaitytė E
- Subjects
- Adult, Carcinoma surgery, Female, Humans, Male, Multiple Endocrine Neoplasia Type 1 surgery, Pedigree, Carcinoma genetics, Carcinoma pathology, Germ-Line Mutation, Multiple Endocrine Neoplasia Type 1 genetics, Multiple Endocrine Neoplasia Type 1 pathology, Parathyroid Glands pathology, Proto-Oncogene Proteins genetics
- Abstract
Multiple endocrine neoplasia type 1 (MEN 1) is a rare syndrome inherited in an autosomal dominant pattern, characterized by combinations of tumors of the parathyroid glands, pituitary gland, and pancreatic islet cells and more rare tumors of endocrine organs and nonendocrine tissues. Germline mutations in the MEN1 gene are responsible for the MEN 1 syndrome, leading to an inactive form of menin protein. Benign lesions of the parathyroid glands are characteristic in patients with the MEN 1 syndrome; however, patients can develop parathyroid carcinomas very rarely. This report presents a clinical case of the MEN 1 syndrome: a 39-year-old woman underwent surgery for carcinoma of two parathyroid glands as well as was treated for pituitary prolactinoma, which caused infertility, and malignant insulinoma; the patient had multiple subcutaneous lipomas as well. Genetic analysis revealed a novel germline mutation in the MEN1 gene - a nucleotide insertion at codon 43 in exon 2 (c.129insA), which caused the occurrence of the MEN1 syndrome. The clinical case of the MEN 1 syndrome presented here is relevant in gathering the data on etiopathogenesis of not only MEN 1 syndrome, but an extremely rare pathology - parathyroid carcinoma - as well.
- Published
- 2011
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