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28 results on '"Verhoeff Arie"'

1. The OPTIMIST study: optimisation of cost effectiveness through individualised FSH stimulation dosages for IVF treatment. A randomised controlled trial

Author

van Tilborg Theodora C, Eijkemans Marinus JC, Laven Joop SE, Koks Carolien AM, de Bruin Jan, Scheffer Gabrielle J, van Golde Ron JT, Fleischer Kathrin, Hoek Annemieke, Nap Annemiek W, Kuchenbecker Walter KH, Manger Petra A, Brinkhuis Egbert A, van Heusden Arne M, Sluijmer Alexander V, Verhoeff Arie, van Hooff Marcel HA, Friederich Jaap, Smeenk Jesper MJ, Kwee Janet, Verhoeve Harold R, Lambalk Cornelis B, Helmerhorst Frans M, van der Veen Fulco, Mol Ben Willem J, Torrance Helen L, and Broekmans Frank JM

Subjects
Ovarian reserve, Antral follicle count, IVF, Individualised FSH stimulation dosages, Live birth rate, Gynecology and obstetrics, RG1-991, Public aspects of medicine, RA1-1270
Abstract

Abstract Background Costs of in vitro fertilisation (IVF) are high, which is partly due to the use of follicle stimulating hormone (FSH). FSH is usually administered in a standard dose. However, due to differences in ovarian reserve between women, ovarian response also differs with potential negative consequences on pregnancy rates. A Markov decision-analytic model showed that FSH dose individualisation according to ovarian reserve is likely to be cost-effective in women who are eligible for IVF. However, this has never been confirmed in a large randomised controlled trial (RCT). The aim of the present study is to assess whether an individualised FSH dose regime based on an ovarian reserve test (ORT) is more cost-effective than a standard dose regime. Methods/Design Multicentre RCT in subfertile women indicated for a first IVF or intracytoplasmic sperm injection cycle, who are aged Discussion The results of this study will be integrated into a decision model that compares cost-effectiveness of the three dose-adjustment strategies to a standard dose strategy. The study outcomes will provide scientific foundation for national and international guidelines. Trial registration NTR2657

Published
2012
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3. Individualized versus standard FSH dosing in women starting IVF/ICSI: an RCT. Part 1: The predicted poor responder

Author

van Tilborg, Theodora C, Torrance, Helen L, Oudshoorn, Simone C, Eijkemans, Marinus J C, Koks, Carolien A M, Verhoeve, Harold R, Nap, Annemiek W, Scheffer, Gabrielle J, Manger, A Petra, Schoot, Benedictus C, Sluijmer, Alexander V, Verhoeff, Arie, Groen, Henk, Laven, Joop S E, Mol, Ben Willem J, Broekmans, Frank J M, van Tilborg, Theodora C, Oudshoorn, Simone C, Eijkemans, Marinus J C, Mochtar, Monique H, Koks, Carolien A M, van Golde, Ron J T, Verhoeve, Harold R, Nap, Annemiek W, Scheffer, Gabrielle J, Manger, A Petra, Hoek, Annemieke, Schoot, Bendictus C, Oosterhuis, G Jur E, Kuchenbecker, Walter K H, Fleischer, Kathrin, de Bruin, Jan Peter, Sluijmer, Alexander V, Friederich, Jaap, Verhoeff, Arie, van Hooff, Marcel H A, van Santbrink, Evert J P, Brinkhuis, Egbert A, Smeenk, Jesper M J, Kwee, Janet, de Koning, Corry H, Groen, Henk, van Wely, Madelon, Lambalk, Cornelis B, Laven, Joop S E, Mol, Ben Willem J, Broekmans, Frank J M, and Torrance, Helen L

Published
2017
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4. Elevated early follicular progesterone levels and in vitro fertilization outcomes: a prospective intervention study and meta-analysis

Author

Hamdine, Ouijdane, Macklon, Nick S., Eijkemans, Marinus J.C., Laven, Joop S.E., Cohlen, Bernard J., Verhoeff, Arie, van Dop, Peter A., Bernardus, Rob E., Lambalk, Cornelis B., Oosterhuis, Gerrit J.E., Holleboom, Caspar A.G., van den Dool-Maasland, Grada C., Verburg, Harjo J., van der Heijden, Petrus F.M., Blankhart, Adrienne, Fauser, Bart C.J.M., and Broekmans, Frank J.

Published
2014
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5. Individualized versus standard FSH dosing in women starting IVF/ICSI: an RCT. Part 2: The predicted hyper responder

Author

Oudshoorn, Simone C, van Tilborg, Theodora C, Eijkemans, Marinus J C, Oosterhuis, G Jur E, Friederich, Jaap, van Hooff, Marcel H A, van Santbrink, Evert J P, Brinkhuis, Egbert A, Smeenk, Jesper M J, Kwee, Janet, de Koning, Corry H, Groen, Henk, Lambalk, Cornelis B, Mol, Ben Willem J, Broekmans, Frank J M, Torrance, Helen L, van Tilborg, Theodora C, Oudshoorn, Simone C, Eijkemans, Marinus J C, Mochtar, Monique H, Koks, Carolien A M, van Golde, Ron J T, Verhoeve, Harold R, Nap, Annemiek W, Scheffer, Gabrielle J, Manger, A Petra, Hoek, Annemieke, Schoot, Bendictus C, Oosterhuis, G Jur E, Kuchenbecker, Walter K H, Fleischer, Kathrin, de Bruin, Jan Peter, Sluijmer, Alexander V, Friederich, Jaap, Verhoeff, Arie, van Hooff, Marcel H A, van Santbrink, Evert J P, Brinkhuis, Egbert A, Smeenk, Jesper M J, Kwee, Janet, de Koning, Corry H, Groen, Henk, van Wely, Madelon, Lambalk, Cornelis B, Laven, Joop S E, Mol, Ben Willem J, Broekmans, Frank J M, and Torrance, Helen L

Published
2017
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6. Individualized FSH dosing based on ovarian reserve testing in women starting IVF/ICSI: a multicentre trial and cost-effectiveness analysis

Author

van Tilborg, Theodora C, Oudshoorn, Simone C, Eijkemans, Marinus J C, Mochtar, Monique H, van Golde, Ron J T, Hoek, Annemieke, Kuchenbecker, Walter K H, Fleischer, Kathrin, de Bruin, Jan Peter, Groen, Henk, van Wely, Madelon, Lambalk, Cornelis B, Laven, Joop S E, Mol, Ben Willem J, Broekmans, Frank J M, Torrance, Helen L, van Tilborg, Theodora C, Oudshoorn, Simone C, Eijkemans, Marinus J C, Mochtar, Monique H, Koks, Carolien A M, van Golde, Ron J T, Verhoeve, Harold R, Nap, Annemiek W, Scheffer, Gabrielle J, Manger, A Petra, Hoek, Annemieke, Schoot, Bendictus C, Oosterhuis, G Jur E., Kuchenbecker, Walter K H, Fleischer, Kathrin, de Bruin, Jan Peter, Sluijmer, Alexander V, Friederich, Jaap, Verhoeff, Arie, van Hooff, Marcel H A, van Santbrink, Evert J P, Brinkhuis, Egbert A, Smeenk, Jesper M J, Kwee, Janet, de Koning, Corry H, Groen, Henk, van Wely, Madelon, Lambalk, Cornelis B, Laven, Joop S E, Mol, Ben Willem J, Broekmans, Frank J M, and Torrance, Helen L

Published
2017
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11. Do female age and body weight modify the effect of individualized FSH dosing in IVF/ICSI treatment? A secondary analysis of the OPTIMIST trial

Author

Leijdekkers, Jori A., van Tilborg, Theodora C., Torrance, Helen L., Oudshoorn, Simone C., Brinkhuis, Egbert A., Koks, Carolien A. M., Lambalk, Cornelis B., de Bruin, Jan Peter, Fleischer, Kathrin, Mochtar, Monique H., Kuchenbecker, Walter K. H., Laven, Joop S. E., Mol, Ben Willem J., Broekmans, Frank J. M., Eijkemans, Marinus J. C., van Golde, Ron J. T., Verhoeve, Harold R., Nap, Annemiek W., Scheffer, Gabrielle J., Manger, A. Petra, Hoek, Annemieke, Schoot, Bendictus C., Oosterhuis, G. Jur E., Sluijmer, Alexander V., Friederich, Jaap, Verhoeff, Arie, van Hooff, Marcel H. A., van Santbrink, Evert J. P., Smeenk, Jesper M. J., Kwee, Janet, de Koning, Corry H., Groen, Henk, van Wely, Madelon, Graduate School, Center for Reproductive Medicine, Amsterdam Reproduction & Development (AR&D), APH - Personalized Medicine, APH - Methodology, Obstetrics and gynaecology, ACS - Atherosclerosis & ischemic syndromes, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, Cardiology, Obstetrics & Gynecology, Reproductive Origins of Adult Health and Disease (ROAHD), and Value, Affordability and Sustainability (VALUE)

Subjects
antral follicle count, in vitro fertilization/intracytoplasmic sperm injection, Adult, medicine.medical_specialty, medicine.medical_treatment, Ovarian hyperstimulation syndrome, intracytoplasmic sperm injection, Fertilization in Vitro, Logistic regression, Intracytoplasmic sperm injection, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], All institutes and research themes of the Radboud University Medical Center, individualized follicle-stimulating hormone dosing, Obstetrics and Gynaecology, ovarian hyperstimulation syndrome, Journal Article, Medicine, Humans, Dosing, Prospective Studies, Sperm Injections, Intracytoplasmic, Netherlands, In vitro fertilisation, business.industry, Obstetrics, Body Weight, Age Factors, Obstetrics and Gynecology, General Medicine, Antral follicle, medicine.disease, female age, Female, Follicle Stimulating Hormone, business, Live birth, in vitro fertilization, effect modification, Live Birth, Hormone
Abstract

Introduction: The OPTIMIST trial revealed that for women starting in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatment, no substantial differences exist in first cycle and cumulative live birth rates between an antral follicle count (AFC)-based individualized follicle-stimulating hormone (FSH) dose and a standard dose. Female age and body weight have been suggested to cause heterogeneity in the effect of FSH dose individualization. The objective of the current study is to evaluate whether these patient characteristics modify the effect of AFC-based individualized FSH dosing in IVF/ICSI treatment.Material and methods: A secondary data-analysis of the OPTIMIST trial. Women initiating IVF/ICSI treatment were classified as predicted poor (AFC 0-7), suboptimal (AFC 8-10) or hyper responders (AFC >15), and randomly allocated to a standard FSH dose (150 IU/d) or an individualized FSH dose (450, 225 or 100 IU/d for predicted poor, suboptimal and hyper responders, respectively). In each predicted response category, logistic regression models with interaction terms were used to evaluate the presence of effect modification. The first cycle was analyzed, and the primary outcomes were first complete cycle live birth rate (including fresh plus frozen-thawed embryo transfers) and ovarian hyperstimulation syndrome (OHSS) risks.Results: No effect modification was revealed in the predicted poor (n = 234) and suboptimal (n = 277) responders. In the predicted hyper responders (n = 521), the effect of the individualized FSH dose on the first cycle live birth rate was modified by female age (P = 0.02) and the effect on OHSS risks was modified by body weight (P = 0.02). A dose reduction from 150 to 100 IU/d generally decreased the OHSS risks in predicted hyper responders, but also reduced the chance of a live birth in young women, and had no beneficial impact on OHSS risks in women with a relatively low body weight.Conclusions: In women with a predicted hyper response undergoing IVF/ICSI treatment, female age and body weight seem to modify the effect of FSH dose individualization. Although a reduced FSH starting dose generally decreases the OHSS risks, it may also reduce the chance of a live birth, specifically for young women. Future studies could consider these findings when investigating the optimal approach to reduce OHSS risks while maintaining the probability of a live birth for predicted hyper responders in IVF/ICSI treatment.

Published
2018
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17. Oocytes—Will Travel?

Author

McDonough, Paul G., primary, Roest, Jan, additional, Verhoeff, Arie, additional, Coetsier, Tom, additional, De Sutter, Paul, additional, Dozortsev, Dima, additional, Dhont, Marc, additional, and Zeilmaker, Gerald H., additional

Published
1995
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27. Effects of Experimental Head Compression on Transcutaneous Scalp Po2in Fetal Lambs

Author

WALLENBURG, HENK C. S., VERHOEFF, ARIE, JANSEN, T. CEES, and WIEL, ANDRÉ R. VAN DER

Abstract

Equatorial compression of the fetal head is known to occur during labor; its effect on trancutaneous scalp Po2(Ptco2) was investigated in acute experiments in four fetal lambs. Fetal Ptco2, and oxygen tension (Pao2) and flow in a carotid artery were continuously measured. Equatorial head compression was obtained by inflating a cuff around the fetal head. A strong relationship was shown to exist between Ptco2and Pao2values in the normoxemic and hypoxemic fetus. Stepwise compression of the fetal head resulted in a Ptco2of zero at cuff pressures of 40 to 50 mmHg. Laborlike fetal head compression with an intensity of 50 to 70 mmHg and a duration of one minute resulted in a 30 to 60 fall in Ptco2. Fetal Pao2remained stable in all experiments. The present findings indicate that values of Ptco2during fetal head compression do not reflect fetal arterial oxygen tension. This questions the reliability of transcutaneous Po2monitoring as a method of intrapartum surveillance.

Published
1984

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