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286 results on '"Verhamme, Katia M. C."'

3. Drug utilization analysis of osteoporosis medications in seven European electronic health databases

Author

Tan, Eng Hooi, Robinson, Danielle E., Jödicke, Annika M., Mosseveld, Mees, Bødkergaard, Katrine, Reyes, Carlen, Moayyeri, Alireza, Voss, Annemarie, Marconi, Ettore, Lapi, Francesco, Reinold, Jonas, Verhamme, Katia M. C., Pedersen, Lars, Braitmaier, Malte, de Wilde, Marcel, Ruiz, Marc Far, Aragón, María, Bosco-Levy, Pauline, Lassalle, Regis, Prieto-Alhambra, Daniel, and Sanchez-Santos, Maria T.

Published
2023
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7. Parasitic infections related to anti-type 2 immunity monoclonal antibodies: a disproportionality analysis in the food and drug administration’s adverse event reporting system (FAERS)

Author

Pera, Victor, primary, Brusselle, Guy G., additional, Riemann, Sebastian, additional, Kors, Jan A., additional, Van Mulligen, Erik M., additional, Parry, Rowan, additional, de Wilde, Marcel, additional, Rijnbeek, Peter R., additional, and Verhamme, Katia M. C., additional

Published
2023
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8. Chronic Cough-Related Differences in Brain Morphometry in Adults:A Population-Based Study

Author

Arinze, Johnmary T, Vinke, Elisabeth J, Verhamme, Katia M C, de Ridder, Maria A J, Stricker, Bruno, Ikram, M K, Brusselle, Guy, Vernooij, Meike W, Arinze, Johnmary T, Vinke, Elisabeth J, Verhamme, Katia M C, de Ridder, Maria A J, Stricker, Bruno, Ikram, M K, Brusselle, Guy, and Vernooij, Meike W

Abstract

Background: Individuals with cough hypersensitivity have increased central neural responses to tussive stimuli, which may result in maladaptive morphometric changes in the central cough processing systems. Research Question: Are the volumes of the brain regions implicated in cough hypersensitivity different in adults with chronic cough compared with adults without chronic cough? Study Design and Methods: Between 2009 and 2014, participants in the Rotterdam Study, a population-based cohort, underwent brain MRI and were interviewed for chronic cough, which was defined as daily coughing for at least 3 months. Regional brain volumes were quantified with the use of parcellation software. Based on literature review, we identified and studied seven brain regions that previously had been associated with altered functional brain activity in chronic cough. The relationship between chronic cough and regional brain volumes was investigated with the use of multivariable regression models. Results: Chronic cough was prevalent in 9.6% (No. = 349) of the 3,620 study participants (mean age, 68.5 ± 9.0 years; 54.6% female). Participants with chronic cough had significantly smaller anterior cingulate cortex volume than participants without chronic cough (mean difference, ˗126.16 mm 3; 95% CI, −245.67 to −6.66; P = .039). Except for anterior cingulate cortex, there were no significant difference in the volume of other brain regions based on chronic cough status. The volume difference in the anterior cingulate cortex was more pronounced in the left hemisphere (mean difference, −88.11 mm 3; 95% CI, −165.16 to −11.06; P = .025) and in male participants (mean difference, −242.58 mm 3; 95% CI, −428.60 to −56.55; P = .011). Interpretation: Individuals with chronic cough have a smaller volume of the anterior cingulate cortex, which is a brain region involved in cough suppression. Clinical Trial Registration: The Netherlands National Trial Registry (NTR; www

Published
2023

9. Descriptive analysis on disproportionate medication errors and associated patient characteristics in the Food and Drug Administration's Adverse Event Reporting System.

Author

Pera, Victor, van Vaerenbergh, Frauke, Kors, Jan A., van Mulligen, Erik M., Parry, Rowan, de Wilde, Marcel, Lahousse, Lies, van der Lei, Johan, Rijnbeek, Peter R., and Verhamme, Katia M. C.

Abstract

Background: Medication errors (MEs) are a major public health concern which can cause harm and financial burden within the healthcare system. Characterizing MEs is crucial to develop strategies to mitigate MEs in the future. Objectives: To characterize ME‐associated reports, and investigate signals of disproportionate reporting (SDRs) on MEs in the Food and Drug Administration's Adverse Event Reporting System (FAERS). Methods: FAERS data from 2004 to 2020 was used. ME reports were identified with the narrow Standardised Medical Dictionary for Regulatory Activities® (MedDRA®) Query (SMQ) for MEs. Drug names were converted to the Anatomical Therapeutic Chemical (ATC) classification. SDRs were investigated using the reporting odds ratio (ROR). Results: In total 488 470 ME reports were identified, mostly (59%) submitted by consumers and mainly (55%) associated with females. Median age at time of ME was 57 years (interquartile range: 37–70 years). Approximately 1 out of 3 reports stated a serious health outcome. The most prevalent reported drug class was "antineoplastic and immunomodulating agents" (25%). The most common ME type was "incorrect dose administered" (9%). Of the 1659 SDRs obtained, adalimumab was the most common drug associated with MEs, noting a ROR of 1.22 (95% confidence interval: 1.21–1.24). Conclusion: This study offers a first of its kind characterization of MEs as reported to FAERS. Reported MEs are frequent and may be associated with serious health outcomes. This FAERS data provides insights on ME prevention and offers possibilities for additional in‐depth analyses. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Characterising the treatment of thromboembolic events after COVID-19 vaccination in 4 European countries and the US: An international network cohort study

Author

Markus, Aniek F., primary, Strauss, Victoria Y., additional, Burn, Edward, additional, Li, Xintong, additional, Delmestri, Antonella, additional, Reich, Christian, additional, Yin, Can, additional, Mayer, Miguel A., additional, Ramírez-Anguita, Juan-Manuel, additional, Marti, Edelmira, additional, Verhamme, Katia M. C., additional, Rijnbeek, Peter R., additional, Prieto-Alhambra, Daniel, additional, and Jödicke, Annika M., additional

Published
2023
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15. Drug Use in Children: Cohort Study in Three European Countries

Author

Sturkenboom, Miriam C. J. M., Verhamme, Katia M. C., Nicolosi, Alfredo, Murray, Macey L., Neubert, Antje, Caudri, Daan, Picelli, Gino, Sen, Elif Fatma, Giaquinto, Carlo, Cantarutti, Luigi, Baiardi, Paola, Felisi, Maria-Grazia, Ceci, Adriana, and Wong, Ian C. K.

Published
2008

21. Signal Detection of Potentially Drug-Induced Acute Liver Injury in Children Using a Multi-Country Healthcare Database Network

Author

Ferrajolo, Carmen, Coloma, Preciosa M., Verhamme, Katia M. C., Schuemie, Martijn J., de Bie, Sandra, Gini, Rosa, Herings, Ron, Mazzaglia, Giampiero, Picelli, Gino, Giaquinto, Carlo, Scotti, Lorenza, Avillach, Paul, Pedersen, Lars, Rossi, Francesco, Capuano, Annalisa, van der Lei, Johan, Trifiró, Gianluca, Sturkenboom, Miriam C. J. M., and EU-ADR consortium

Published
2014
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22. Challenges of Estimating Global Feature Importance in Real-World Health Care Data.

Author

MARKUS, Aniek F., FRIDGEIRSSON, Egill A., KORS, Jan A., VERHAMME, Katia M. C., and RIJNBEEK, Peter R.

Abstract

Feature importance is often used to explain clinical prediction models. In this work, we examine three challenges using experiments with electronic health record data: computational feasibility, choosing between methods, and interpretation of the resulting explanation. This work aims to create awareness of the disagreement between feature importance methods and underscores the need for guidance to practitioners how to deal with these discrepancies. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Data Resource Profile: The Integrated Primary Care Information (IPCI) database, The Netherlands.

Author

Ridder, Maria A J de, Wilde, Marcel de, Ben, Christina de, Leyba, Armando R, Mosseveld, Bartholomeus M T, Verhamme, Katia M C, van der Lei, Johan, and Rijnbeek, Peter R

Subjects
PRIMARY care, INTEGRATIVE medicine, HEALTH information technology, MEDICAL informatics, BARRETT'S esophagus
Abstract

Weaknesses Missing data The primary aim of data collection by GPs is patient management, and the data are therefore not customized for medical research purposes This implies that only information deemed to be relevant to the patient's care is collected and entered into the patient's file. Key Features The Integrated Primary Care Information Project (IPCI) database contains longitudinal data of patients of a group of general practitioners (GPs) in The Netherlands. Data validity Because data in the GP systems are collected with patient management as the main goal, caution is needed when using IPCI data for research purposes. The Integrated Primary Care Information database The Integrated Primary Care Information (IPCI) database is a database containing longitudinal, routinely collected data from computer-based patient records of around 350 GP practices throughout The Netherlands. [Extracted from the article]

Published
2022
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29. Identification of ROBO2 as a Potential Locus Associated with Inhaled Corticosteroid Response in Childhood Asthma

Author

Hernandez-Pacheco, Natalia, primary, Gorenjak, Mario, additional, Li, Jiang, additional, Repnik, Katja, additional, Vijverberg, Susanne J., additional, Berce, Vojko, additional, Jorgensen, Andrea, additional, Karimi, Leila, additional, Schieck, Maximilian, additional, Samedy-Bates, Lesly-Anne, additional, Tavendale, Roger, additional, Villar, Jesús, additional, Mukhopadhyay, Somnath, additional, Pirmohamed, Munir, additional, Verhamme, Katia M. C., additional, Kabesch, Michael, additional, Hawcutt, Daniel B., additional, Turner, Steve, additional, Palmer, Colin N., additional, Tantisira, Kelan G., additional, Burchard, Esteban G., additional, Maitland-van der Zee, Anke H., additional, Flores, Carlos, additional, Potočnik, Uroš, additional, and Pino-Yanes, Maria, additional

Published
2021
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30. Global epidemiology of hip fractures: a study protocol using a common analytical platform among multiple countries

Author

Sing, Chor-Wing, primary, Lin, Tzu-Chieh, additional, Bartholomew, Sharon, additional, Bell, J Simon, additional, Bennett, Corina, additional, Beyene, Kebede, additional, Bosco‐Lévy, Pauline, additional, Chan, Amy Hai Yan, additional, Chandran, Manju, additional, Cheung, Ching-Lung, additional, Doyon, Caroline Y, additional, Droz-Perroteau, Cécile, additional, Ganesan, Ganga, additional, Hartikainen, Sirpa, additional, Ilomaki, Jenni, additional, Jeong, Han Eol, additional, Kiel, Douglas P, additional, Kubota, Kiyoshi, additional, Lai, Edward Chia-Cheng, additional, Lange, Jeff, additional, Lewiecki, E Michael, additional, Liu, Jiannong, additional, Man, Kenneth K C, additional, Mendes de Abreu, Mirhelen, additional, Moore, Nicolas, additional, O’Kelly, James, additional, Ooba, Nobuhiro, additional, Pedersen, Alma B, additional, Prieto-Alhambra, Daniel, additional, Shin, Ju-Young, additional, Sørensen, Henrik T, additional, Tan, Kelvin Bryan, additional, Tolppanen, Anna-Maija, additional, Verhamme, Katia M C, additional, Wang, Grace Hsin-Min, additional, Watcharathanakij, Sawaeng, additional, Zhao, Hongxin, additional, and Wong, Ian C K, additional

Published
2021
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32. Combined analysis of transcriptomic and genetic data for the identification of loci involved in glucocorticosteroid response in asthma

Author

Hernández-Pacheco, Natalia, Gorenjak, Mario, Jurgec, Staša, Corrales, Almudena, Jorgensen, Andrea, Karimi, Leila, Vijverberg, Susanne J, Berce, Vojko, Schieck, Maximilian, Acosta-Herrera, Marialbert, Kerick, Martin, Samedy-Bates, Lesly-Anne, Tavendale, Roger, Villar, Jesús, Mukhopadhyay, S., Pirmohamed, Munir, Verhamme, Katia M C, Kabesch, Michael, Hawcutt, Daniel B, Turner, Steve, Palmer, Colin N, Burchard, Esteban G, Maitland-van der Zee, Anke H, Flores, Carlos, Potočnik, Uroš, Pino-Yanes, María, PiCA and SysPharmPedia consortia, Hernández-Pacheco, Natalia, Gorenjak, Mario, Jurgec, Staša, Corrales, Almudena, Jorgensen, Andrea, Karimi, Leila, Vijverberg, Susanne J, Berce, Vojko, Schieck, Maximilian, Acosta-Herrera, Marialbert, Kerick, Martin, Samedy-Bates, Lesly-Anne, Tavendale, Roger, Villar, Jesús, Mukhopadhyay, S., Pirmohamed, Munir, Verhamme, Katia M C, Kabesch, Michael, Hawcutt, Daniel B, Turner, Steve, Palmer, Colin N, Burchard, Esteban G, Maitland-van der Zee, Anke H, Flores, Carlos, Potočnik, Uroš, Pino-Yanes, María, and PiCA and SysPharmPedia consortia

Published
2021

33. Women are started on a lower daily dose of metoprolol than men irrespective of dose recommendations::A potential source of confounding by contraindication in pharmacoepidemiology

Author

Hendriksen, Linda C., Verhamme, Katia M. C., Van der Linden, Paul D., Stricker, Bruno H., Visser, Loes E., Hendriksen, Linda C., Verhamme, Katia M. C., Van der Linden, Paul D., Stricker, Bruno H., and Visser, Loes E.

Abstract

Purpose: Current guidelines have no sex-specific dosage advice for metoprolol. To evalu-ate whether women and men are prescribed the same dose a cohort analysis was per-formed in the population-based Rotterdam Study (RS). Results were replicated in theIntegrated Primary Care Information (IPCI) database of automated general practice data.Methods: The mean daily starting doses of metoprolol in both sexes were comparedwith independent-samples t-tests and a linear regression analysis was used to adjustin the RS for co-variables, notably, cardiovascular comorbidity, migraine, age, SBP,DBP, BMI, socioeconomic status, use of other antihypertensive drugs, smoking, andalcohol. In the IPCI-database, adjustment was for age only.Results: The mean daily starting dose was statistically significantly lower in womenthan in men in both the RS and IPCI database, with a mean difference of 4.8 mg (95%CI −7.8, −1.8) and 4.6 mg (95%CI −5.3,-4.0), respectively. Statistical significanceremained after adjustment in both databases.Conclusions: Women received lower starting doses of metoprolol than men in twoindependent data collections despite non-sex specific cardiovascular guideline rec-ommendations. This example of real-life pharmacotherapy can lead to a form of con-founding by contraindication in pharmacoepidemiology

Published
2021

41. Incidence, risk factors and re‐exacerbation rate of severe asthma exacerbations in a multinational, multidatabase pediatric cohort study

Author

Engelkes, Marjolein, primary, Baan, Esme J., additional, Ridder, Maria A. J., additional, Svensson, Elisabeth, additional, Prieto‐Alhambra, Daniel, additional, Lapi, Francesco, additional, Giaquinto, Carlo, additional, Picelli, Gino, additional, Boudiaf, Nada, additional, Albers, Frank, additional, Evitt, Lee A., additional, Cockle, Sarah, additional, Bradford, Eric, additional, Van Dyke, Melissa K., additional, Suruki, Robert, additional, Rijnbeek, Peter, additional, Sturkenboom, Miriam C. J. M., additional, Janssens, Hettie M., additional, and Verhamme, Katia M. C., additional

Published
2020
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47. Incidence, risk factors and re-exacerbation rate of severe asthma exacerbations in a multinational, multidatabase pediatric cohort study

Author

Engelkes, Marjolein, Baan, Esme J., de Ridder, Maria A. J., Svensson, Elisabeth, Prieto-Alhambra, Daniel, Lapi, Francesco, Giaquinto, Carlo, Picelli, Gino, Boudiaf, Nada, Albers, Frank, Evitt, Lee A., Cockle, Sarah, Bradford, Eric, Van Dyke, Melissa K., Suruki, Robert, Rijnbeek, Peter, Sturkenboom, Miriam C. J. M., Janssens, Hettie M., Verhamme, Katia M. C., and Universitat Autònoma de Barcelona

Subjects
prevalence [Epidemiology], immune system diseases, parasitic diseases, epidemiology [Asthma], respiratory tract diseases, risk factors [Asthma]
Abstract

Altres ajuts: This trial was funded by Eli Lilly and Company. There are sparse real-world data on severe asthma exacerbations (SAE) in children. This multinational cohort study assessed the incidence of and risk factors for SAE and the incidence of asthma-related rehospitalization in children with asthma. Asthma patients 5-17 years old with ≥1 year of follow-up were identified in six European electronic databases from the Netherlands, Italy, the UK, Denmark and Spain in 2008-2013. Asthma was defined as ≥1 asthma-specific disease code within 3 months of prescriptions/dispensing of asthma medication. Severe asthma was defined as high-dosed inhaled corticosteroids plus a second controller. SAE was defined by systemic corticosteroids, emergency department visit and/or hospitalization all for reason of asthma. Risk factors for SAE were estimated by Poisson regression analyses. The cohort consisted of 212 060 paediatric asthma patients contributing to 678 625 patient-years (PY). SAE rates ranged between 17 and 198/1000 PY and were higher in severe asthma and highest in severe asthma patients with a history of exacerbations. Prior SAE (incidence rate ratio 3-45) and younger age increased the SAE risk in all countries, whereas obesity, atopy and GERD were a risk factor in some but not all countries. Rehospitalization rates were up to 79% within 1 year. In a real-world setting, SAE rates were highest in children with severe asthma with a history of exacerbations. Many severe asthma patients were rehospitalized within 1 year. Asthma management focusing on prevention of SAE is important to reduce the burden of asthma.

Published
2020

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