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684 results on '"Verhaeghe, J"'

2. Semi-quantification and grading of amyloid PET: A project of the European Alzheimer's Disease Consortium (EADC)

Author

Chincarini, A., Peira, E., Morbelli, S., Pardini, M., Bauckneht, M., Arbizu, J., Castelo-Branco, M., Büsing, K.A., de Mendonça, A., Didic, M., Dottorini, M., Engelborghs, S., Ferrarese, C., Frisoni, G.B., Garibotto, V., Guedj, E., Hausner, L., Hugon, J., Verhaeghe, J., Mecocci, P., Musarra, M., Queneau, M., Riverol, M., Santana, I., Guerra, U.P., and Nobili, F.

Published
2019
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6. Sentinel lymph node biopsy without axillary lymphadenectomy after neoadjuvant chemotherapy is accurate and safe for selected patients: the GANEA 2 study

Author

Classe, Jean-Marc, Loaec, Cecile, Gimbergues, P., Alran, S., de Lara, C. Tunon, Dupre, P. F., Rouzier, Roman, Faure, C., Paillocher, N., Chauvet, M. P., Houvenaeghel, G., Gutowski, M., De Blay, P., Verhaeghe, J. L., Barranger, E., Lefebvre, C., Ngo, C., Ferron, G., Palpacuer, C., and Campion, L.

Published
2019
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9. Quantitative Rezeptor-PET in der präklinischen Bildgebung: Vergleich von intravenöser und intraperitonealer Radiotracerapplikation anhand des Beispiels des Adenosin A1 Rezeptor-Tracers F-18-CPFPX

Author

Kroll, T., additional, Miranda, A., additional, Drechsel, A., additional, Klein, S., additional, Elmenhorst, D., additional, Beer, S., additional, Neumaier, B., additional, Drzezga, A., additional, Verhaeghe, J., additional, and Bauer, A., additional

Published
2023
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10. Bayesian Integrated Reservoir Characterization, BIRCh, and its Application to the Raven Field

Author

Paramo, P., primary, Wolf, K., additional, Zhang, J., additional, Biswas, R., additional, Walker, M., additional, Winterbourne, J., additional, Roy, A., additional, Morris, P., additional, Decalf, C., additional, Cook, P., additional, Verhaeghe, J., additional, Brown, R., additional, Gerth, S., additional, Packer, K., additional, and Zheng, Y., additional

Published
2023
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11. Gaussian Mixture Models as Priors in a Gradient-Based Variational Algorithm for Bayesian Elastic Inversion

Author

Walker, M., primary, Paramo, P., additional, Wolf, K., additional, Zhang, J., additional, Biswas, R., additional, Decalf, C., additional, Gerth, S., additional, Packer, K., additional, Winterbourne, J., additional, Roy, A., additional, Morris, P., additional, Verhaeghe, J., additional, Brown, R., additional, Cook, P., additional, Zheng, Y., additional, and Warnick, R., additional

Published
2023
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23. Semi-quantification and grading of amyloid PET: A project of the European Alzheimer's Disease Consortium (EADC)

Author

Chincarini, A, Peira, E, Morbelli, S, Pardini, M, Bauckneht, M, Arbizu, J, Castelo-Branco, M, Busing, K, de Mendonca, A, Didic, M, Dottorini, M, Engelborghs, S, Ferrarese, C, Frisoni, G, Garibotto, V, Guedj, E, Hausner, L, Hugon, J, Verhaeghe, J, Mecocci, P, Musarra, M, Queneau, M, Riverol, M, Santana, I, Guerra, U, Nobili, F, Chincarini A., Peira E., Morbelli S., Pardini M., Bauckneht M., Arbizu J., Castelo-Branco M., Busing K. A., de Mendonca A., Didic M., Dottorini M., Engelborghs S., Ferrarese C., Frisoni G. B., Garibotto V., Guedj E., Hausner L., Hugon J., Verhaeghe J., Mecocci P., Musarra M., Queneau M., Riverol M., Santana I., Guerra U. P., Nobili F., Chincarini, A, Peira, E, Morbelli, S, Pardini, M, Bauckneht, M, Arbizu, J, Castelo-Branco, M, Busing, K, de Mendonca, A, Didic, M, Dottorini, M, Engelborghs, S, Ferrarese, C, Frisoni, G, Garibotto, V, Guedj, E, Hausner, L, Hugon, J, Verhaeghe, J, Mecocci, P, Musarra, M, Queneau, M, Riverol, M, Santana, I, Guerra, U, Nobili, F, Chincarini A., Peira E., Morbelli S., Pardini M., Bauckneht M., Arbizu J., Castelo-Branco M., Busing K. A., de Mendonca A., Didic M., Dottorini M., Engelborghs S., Ferrarese C., Frisoni G. B., Garibotto V., Guedj E., Hausner L., Hugon J., Verhaeghe J., Mecocci P., Musarra M., Queneau M., Riverol M., Santana I., Guerra U. P., and Nobili F.

Abstract

Background: amyloid-PET reading has been classically implemented as a binary assessment, although the clinical experience has shown that the number of borderline cases is non negligible not only in epidemiological studies of asymptomatic subjects but also in naturalistic groups of symptomatic patients attending memory clinics. In this work we develop a model to compare and integrate visual reading with two independent semi-quantification methods in order to obtain a tracer-independent multi-parametric evaluation. Methods: We retrospectively enrolled three cohorts of cognitively impaired patients submitted to 18 F-florbetaben (53 subjects), 18 F-flutemetamol (62 subjects), 18 F-florbetapir (60 subjects)PET/CT respectively, in 6 European centres belonging to the EADC. The 175 scans were visually classified as positive/negative following approved criteria and further classified with a 5-step grading as negative, mild negative, borderline, mild positive, positive by 5 independent readers, blind to clinical data. Scan quality was also visually assessed and recorded. Semi-quantification was based on two quantifiers: the standardized uptake value (SUVr)and the ELBA method. We used a sigmoid model to relate the grading with the quantifiers. We measured the readers accord and inconsistencies in the visual assessment as well as the relationship between discrepancies on the grading and semi-quantifications. Conclusion: It is possible to construct a map between different tracers and different quantification methods without resorting to ad-hoc acquired cases. We used a 5-level visual scale which, together with a mathematical model, delivered cut-offs and transition regions on tracers that are (largely)independent from the population. All fluorinated tracers appeared to have the same contrast and discrimination ability with respect to the negative-to-positive grading. We validated the integration of both visual reading and different quantifiers in a more robust framework thus bri

Published
2019

27. TSPO PET upregulation predicts epileptic phenotype at disease onset independently from chronic TSPO expression in a rat model of temporal lobe epilepsy

Author

Bertoglio, D, Amhaoul, H, Goossens, J, Ali, I, Jonckers, E, Bijnens, T, Siano, M, Wyffels, L, Verhaeghe, J, Van Der Linden, A, Staelens, S, Dedeurwaerdere, S, Bertoglio, D, Amhaoul, H, Goossens, J, Ali, I, Jonckers, E, Bijnens, T, Siano, M, Wyffels, L, Verhaeghe, J, Van Der Linden, A, Staelens, S, and Dedeurwaerdere, S

Abstract

Neuroinflammation is a key component of epileptogenesis, the process leading to acquired epilepsy. In recent years, with the development of non-invasive in vivo positron emission tomography (PET) imaging of translocator protein 18 kDa (TSPO), a marker of neuroinflammation, it has become possible to perform longitudinal studies to characterize neuroinflammation at different disease stages in animal models of epileptogenesis. This study aimed to utilize the prognostic capability of TSPO PET imaging at disease onset (2 weeks post-SE) to categorize epileptic rats with distinct seizure burden based on TSPO levels at disease onset and investigate their association to TSPO expression at the chronic epilepsy stage. Controls (n = 14) and kainic acid-induced status epilepticus (KASE) rats (n = 41) were scanned non-invasively with [18F]PBR111 PET imaging measuring TSPO expression. Animals were monitored using video-electroencephalography (vEEG) up to chronic disease (12 weeks post-SE), at which TSPO levels ([3H]PK11195) as well as other post-mortem abnormalities (namely synaptic density ([3H]UCB-J), neuronal loss (NeuN), and neurodegeneration (FjC)) were investigated. By applying multivariate analysis, TSPO PET imaging at disease onset identified three KASE groups with significantly different spontaneous recurrent seizures (SRS) burden (defined as rare SRS, sporadic SRS, and frequent SRS) (p = 0.003). Interestingly, TSPO levels were significantly different when comparing the three KASE groups (p < 0.0001), with the frequent SRS group characterized only by a limited focal TSPO increase at disease onset. On the contrary, TSPO measured during chronic epilepsy was found to be the highest in the frequent SRS group and correlated with seizure burden (r = 0.826, p < 0.0001). Importantly, early and chronic TSPO levels did not correlate (r = -0.05). Finally, significant pathological changes in neuronal loss, synaptic density, and neurodegeneration were found not only when compared to c

Published
2021

30. Combining oxytocin and cognitive bias modification training in a randomized controlled trial: Effects on trust in maternal support

Author

Verhees, M.W.F.T., van IJzendoorn, M.H., Bakermans-Kranenburg, M.J., Ceulemans, E., de Winter, S., Santens, T., Alaerts, K., Casteels, K., Salemink, E., Verhaeghe, J., Bosmans, G., Experimental psychopathology, Leerstoel Engelhard, Clinical Child and Family Studies, LEARN! - Child rearing, Experimental psychopathology, and Leerstoel Engelhard

Subjects
Male, 050103 clinical psychology, Cognitive bias modification, endocrine system, education, Attachment, Experimental and Cognitive Psychology, Placebo, Oxytocin, Trust, law.invention, 03 medical and health sciences, 0302 clinical medicine, Cognition, Randomized controlled trial, Bias, Arts and Humanities (miscellaneous), law, Intervention (counseling), Oxytocics, medicine, Humans, 0501 psychology and cognitive sciences, Levels-of-processing effect, Child, Maternal Behavior, Administration, Intranasal, Cognitive Behavioral Therapy, 05 social sciences, Middle childhood, Social learning, Moderation, Social Learning, 030227 psychiatry, 3. Good health, Clinical Psychology, Psychiatry and Mental health, Female, Psychology, hormones, hormone substitutes, and hormone antagonists, medicine.drug, Clinical psychology
Abstract

BACKGROUND AND OBJECTIVES: Research on the social effects of intranasal oxytocin in children is scarce. Oxytocin has been proposed to have clearer beneficial effects when added to social learning paradigms. The current study tested this proposition in middle childhood by assessing effects of cognitive bias modification (CBM) training and oxytocin on trust in maternal support. METHODS: Children (N = 100, 8-12 years) were randomly assigned to one of two training conditions: CBM training aimed at increasing trust or neutral placebo training. Within each training condition, half the participants received oxytocin and half a placebo. Main and interaction effects were assessed on measures of trust-related interpretation bias and trust. We explored whether child characteristics moderated intervention effects. RESULTS: Children in the CBM training were faster to interpret maternal behaviour securely versus insecurely. Effects did not generalize to interpretation bias measures or trust. There were no main or interaction effects of oxytocin. Exploratory moderation analyses indicated that combining CBM training with oxytocin had less positive effects on trust for children with more internalizing problems. LIMITATIONS: As this was the first study combining CBM and oxytocin, replication of the results is needed. CONCLUSIONS: This study combined a social learning paradigm with oxytocin in children. CBM training was effective at an automatic level of processing. Oxytocin did not enhance CBM effects or independently exert effects. Research in larger samples specifying when oxytocin might have beneficial effects is necessary before oxytocin can be used as intervention option in children. ispartof: Journal Of Behavior Therapy And Experimental Psychiatry vol:66 pages:1-9 ispartof: location:Netherlands status: Published online

Published
2020
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31. Combining oxytocin and cognitive bias modification training in a randomized controlled trial: Effects on trust in maternal support

Author

Experimental psychopathology, Leerstoel Engelhard, Verhees, M.W.F.T., van IJzendoorn, M.H., Bakermans-Kranenburg, M.J., Ceulemans, E., de Winter, S., Santens, T., Alaerts, K., Casteels, K., Salemink, E., Verhaeghe, J., Bosmans, G., Experimental psychopathology, Leerstoel Engelhard, Verhees, M.W.F.T., van IJzendoorn, M.H., Bakermans-Kranenburg, M.J., Ceulemans, E., de Winter, S., Santens, T., Alaerts, K., Casteels, K., Salemink, E., Verhaeghe, J., and Bosmans, G.

Published
2020

38. Vaginal Er:YAG laser application in the menopausal ewe model: a randomised estrogen and sham‐controlled trial

Author

Mackova, K, primary, Mazzer, AM, additional, Mori Da Cunha, MGMC, additional, Hajkova Hympanova, L, additional, Urbankova, I, additional, Kastelein, AW, additional, Vodegel, E, additional, Vander Linden, K, additional, Fehervary, H, additional, Guler, Z, additional, Roovers, JP, additional, Krofta, L, additional, Verhaeghe, J, additional, and Deprest, J, additional

Published
2020
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46. Increased clearance of 1,25(OH)2D3 and tissue-specific responsiveness to 1, 25(OH)2D3 in diabetic rats

Author

Verhaeghe, J., Suiker, A.M.H., Bree, R. van, Herck, E. van, Jans, I., Visser, W.J., Thomasset, M., Allewaert, K., and Bouillon, R.

Subjects
Type 1 diabetes -- Research, Vitamin D metabolism -- Observations, Tissue specific antigens -- Analysis, Biological sciences
Abstract

Male spontaneously diabetic and control BB rats were used to explore the kinetics of 1,25 dihydroxyvitamin D3 and the in wivo response to 1,25 (OH)2D3, injected subcutaneously for 12-14 days. In control rats, the enhancement in plasma 1,25 (OH)2D3 and calcium, urinary calcium, duodenal CaBP9k and renal CaBP28K were equalled by increasing the doses of 1,25 (OH)2D3, which produced these enhancements. Bone mineralization rate was impaired by 1,25 (OH)2D3 at 30ng/100g, which greatly enhanced plasma osteocalcin and osteoblan/osteoid surfaces in the tibial metaphysis.

Published
1993

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