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238 results on '"Verhaar, M. C."'

6. Sex differences in modifiable risk factors for stroke incidence and recurrence: the UCC-SMART study.

Author

Rissanen, Ina, Basten, Maartje, Exalto, Lieza G., Peters, Sanne A. E., Visseren, Frank L. J., Geerlings, Mirjam I., For the UCC-SMART-Study Group, Cramer, M. J., van der Meer, M. G., Nathoe, H. M., de Borst, G. J., Bots, M. L., Geerlings, M. I., Emmelot-Vonk, M. H., de Jong, P. A., Lely, A. T., van der Kaaij, N. P., Kappelle, L. J., Ruigrok, Y. M., and Verhaar, M. C.

Subjects
SEX factors in disease, DISEASE risk factors, DYSLIPIDEMIA, HEMORRHAGIC stroke, PROPORTIONAL hazards models, STROKE
Abstract

Background and purpose: Risk factors for stroke differ between women and men in general populations. However, little is known about sex differences in secondary prevention. We investigated if sex interacted with modifiable risk factors for stroke in a large arterial disease cohort. Methods: Within the prospective UCC-SMART study, 13,898 patients (35% women) with atherosclerotic disease or high-risk factor profile were followed up to 23 years for stroke incidence or recurrence. Hypertension, smoking, diabetes, overweight, dyslipidemia, high alcohol use, and physical inactivity were studied as risk factors. Association between these factors and ischemic and hemorrhagic stroke incidence or recurrence was studied in women and men using Cox proportional hazard models and Poisson regression models. Women-to-men relative hazard ratios (RHR) and rate differences (RD) were estimated for each risk factor. Left-truncated age was used as timescale. Results: The age-adjusted stroke incidence rate was lower in women than men (3.9 vs 4.4 per 1000 person-years), as was the age-adjusted stroke recurrence rate (10.0 vs 11.7). Hypertension and smoking were associated with stroke risk in both sexes. HDL cholesterol was associated with lower stroke incidence in women but not in men (RHR 0.49; CI 0.27–0.88; and RD 1.39; CI − 1.31 to 4.10). Overweight was associated with a lower stroke recurrence in women but not in men (RHR 0.42; CI 0.23–0.80; and RD 9.05; CI 2.78–15.32). Conclusions: In high-risk population, sex modifies the association of HDL cholesterol on stroke incidence, and the association of overweight on stroke recurrence. Our findings highlight the importance of sex-specific secondary prevention. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations

Author

Pei, J., Schuldt, M., Nagyova, E., Gu, Z., el Bouhaddani, S., Yiangou, L., Jansen, M., Calis, J. J. A., Dorsch, L. M., Blok, C. Snijders, van den Dungen, N. A. M., Lansu, N., Boukens, B. J., Efimov, I. R., Michels, M., Verhaar, M. C., de Weger, R., Vink, A., van Steenbeek, F. G., Baas, A. F., Davis, R. P., Uh, H. W., Kuster, D. W. D., Cheng, C., Mokry, M., van der Velden, J., Asselbergs, F. W., and Harakalova, M.

Published
2021
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11. Mapping individual cardiac cell types and their contribution in the development of heart failure in a multiple comorbidity porcine model

Author

Van Dijk, C G M, primary, Peisker, F, additional, Halder, M, additional, Toft Hannani, M, additional, Brandt, M M, additional, Van Drie, R W A, additional, Van De Wouw, J, additional, Sorop, O, additional, Duncker, D J, additional, Merkus, D, additional, Verhaar, M C, additional, Kramann, R, additional, and Cheng, C, additional

Published
2023
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13. Differentiated mouse kidney tubuloids as a novel in vitro model to study collecting duct physiology

Author

UMC Utrecht, Nefro Vasculaire Geneeskunde, MS Nefrologie, Regenerative Medicine and Stem Cells, Circulatory Health, Olde Hanhof, C. J.A., Dilmen, E., Yousef Yengej, F. A., Latta, F., Ammerlaan, C. M.E., Schreurs, J., Hooijmaijers, L., Jansen, J., Rookmaaker, M. B., Orhon, I., Verhaar, M. C., Hoenderop, J. G., UMC Utrecht, Nefro Vasculaire Geneeskunde, MS Nefrologie, Regenerative Medicine and Stem Cells, Circulatory Health, Olde Hanhof, C. J.A., Dilmen, E., Yousef Yengej, F. A., Latta, F., Ammerlaan, C. M.E., Schreurs, J., Hooijmaijers, L., Jansen, J., Rookmaaker, M. B., Orhon, I., Verhaar, M. C., and Hoenderop, J. G.

Published
2023

14. Estimation of recurrent atherosclerotic cardiovascular event risk in patients with established cardiovascular disease

Author

Hageman, Steven H. J., McKay, Ailsa J., Ueda, Peter, Gunn, Laura H., Jernberg, Tomas, Hagström, Emil, Bhatt, Deepak L., Steg, Ph. Gabriel, Läll, Kristi, Mägi, Reedik, Gynnild, Mari Nordbø, Ellekjær, Hanne, Saltvedt, Ingvild, Tuñón, José, Mahíllo, Ignacio, Aceña, Álvaro, Kaminski, Karol, Chlabicz, Malgorzata, Sawicka, Emilia, Tillman, Taavi, McEvoy, John W., di Angelantonio, Emanuele, Graham, Ian, de Bacquer, Dirk, Ray, Kausik K., Dorresteijn, Jannick A. N., Visseren, Frank L. J., Asselbergs, F. W., Nathoe, H. M., de Borst, G. J., Bots, M. L., Geerlings, M. I., Emmelot, M. H., de Jong, P. A., Leiner, T., Lely, A. T., van der Kaaij, N. P., Kappelle, L. J., Ruigrok, Y. M., Verhaar, M. C., Visseren, F. L. J., Westerink, J., Halle, Martin, Timmis, Adam D., Lettino, Maddalena, Vardas, Panos E., McEvoy, John William, Graham, Ian M., and Academic Medical Center

Subjects
Cardiac & Cardiovascular Systems, PREDICTION, Myocardial Infarction, Residual risk, Risk Assessment, ARTERIAL-DISEASE, Recurrent risk, Risk Factors, Medicine and Health Sciences, Humans, Cardiac and Cardiovascular Systems, 1102 Cardiorespiratory Medicine and Haematology, METAANALYSIS, Science & Technology, Kardiologi, Secondary prevention, 1103 Clinical Sciences, ASSOCIATION, Atherosclerosis, Established ASCVD, COMPETING RISKS, PREVENTION, Risk prediction, Stroke, ASPIRIN, Cardiovascular System & Hematology, Cardiovascular Diseases, CLINICAL-PRACTICE, Personalized treatment, Cardiovascular System & Cardiology, Cardiology and Cardiovascular Medicine, OUTPATIENTS, Life Sciences & Biomedicine, Algorithms, Biomarkers, TASK-FORCE
Abstract

Aims The 10-year risk of recurrent atherosclerotic cardiovascular disease (ASCVD) events in patients with established ASCVD can be estimated with the Secondary Manifestations of ARTerial disease (SMART) risk score, and may help refine clinical management. To broaden generalizability across regions, we updated the existing tool (SMART2 risk score) and recalibrated it with regional incidence rates and assessed its performance in external populations. Methods and results Individuals with coronary artery disease, cerebrovascular disease, peripheral artery disease, or abdominal aortic aneurysms were included from the Utrecht Cardiovascular Cohort-SMART cohort [n = 8355; 1706 ASCVD events during a median follow-up of 8.2 years (interquartile range 4.2-12.5)] to derive a 10-year risk prediction model for recurrent ASCVD events (non-fatal myocardial infarction, non-fatal stroke, or cardiovascular mortality) using a Fine and Gray competing risk-adjusted model. The model was recalibrated to four regions across Europe, and to Asia (excluding Japan), Japan, Australia, North America, and Latin America using contemporary cohort data from each target region. External validation used data from seven cohorts [Clinical Practice Research Datalink, SWEDEHEART, the international REduction of Atherothrombosis for Continued Health (REACH) Registry, Estonian Biobank, Spanish Biomarkers in Acute Coronary Syndrome and Biomarkers in Acute Myocardial Infarction (BACS/BAMI), the Norwegian COgnitive Impairment After STroke, and Bialystok PLUS/Polaspire] and included 369 044 individuals with established ASCVD of whom 62 807 experienced an ASCVD event. C-statistics ranged from 0.605 [95% confidence interval (CI) 0.547-0.664] in BACS/BAMI to 0.772 (95% CI 0.659-0.886) in REACH Europe high-risk region. The clinical utility of the model was demonstrated across a range of clinically relevant treatment thresholds for intensified treatment options. Conclusion The SMART2 risk score provides an updated, validated tool for the prediction of recurrent ASCVD events in patients with established ASCVD across European and non-European populations. The use of this tool could allow for a more personalized approach to secondary prevention based upon quantitative rather than qualitative estimates of residual risk. Key objective To improve upon prediction of 10-year residual atherosclerotic cardiovascular disease (ASCVD) event risk in individuals with established ASCVD, by taking into account competing risks and geographical differences in ASCVD incidence. Key findings Derivation in 8355 individuals with established ASCVD from the Utrecht Cardiovascular Cohort-Secondary Manifestations of ARTerial disease (SMART) cohort. C-statistics ranged from 0.605 [95% confidence interval (CI) 0.547-0.664] to 0.772 (95% CI 0.659-0.886). Clinical utility was demonstrated across a range of treatment thresholds relevant to therapy intensification. Take-home messages The SMART2 risk score can be used to estimate 10-year residual risk of fatal and non-fatal ASCVD in individuals with established ASCVD. Adapted to the CVD incidence in several global regions. Facilitates shared decision-making on Step 2 prevention goals as recommended by the 2021 ESC Guidelines on cardiovascular prevention.

Published
2022

16. Differences in mental health status during the COVID-19 pandemic between patients undergoing in-center hemodialysis and peritoneal dialysis.

Author

Bouwmans, Pim, Skalli, Zeinab, Vernooij, Robin W. M., Hemmelder, Marc H., Konijn, Wanda S., Lips, Joy, Mulder, Janneke, Bonenkamp, Anna A., van Jaarsveld, Brigit C., Abrahams, Alferso C., the DOMESTICO study group, Abrahams, A. C., Verhaar, M. C., van Jaarsveld, B. C., Dekker, F. W., van Ittersum, F. J., Konijn, W., Hemmelder, M. H., ten Dam, M. A. G. J., and van Eck van der Sluijs, A.

Published
2023
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20. Microinfarcts in the Deep Gray Matter on 7T MRI: Risk Factors, MRI Correlates, and Relation to Cognitive Functioning-The SMART-MR Study

Author

Ghaznawi, R., Zwartbol, M. H. T., de Bresser, J., Kuijf, H. J., Vincken, K. L., Rissanen, I., Hendrikse, J., Geerlings, Mirjam I., Asselbergs, F. W., Nathoe, H. M., de Borst, G. J., Bots, M. L., Geerlings, M. I., Emmelot, M. H., de Jong, P. A., Leiner, T., Lely, A. T., van der Kaaij, N. P., Kappelle, L. J., Ruigrok, Y., Verhaar, M. C., Visseren, F. L. J., Westerink, J., General practice, APH - Aging & Later Life, APH - Personalized Medicine, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Amsterdam Neuroscience - Neurodegeneration, and ACS - Heart failure & arrhythmias

Subjects
Cognition, Risk Factors, Adult Brain, Humans, Radiology, Nuclear Medicine and imaging, Neurology (clinical), Gray Matter, Carotid Intima-Media Thickness, Magnetic Resonance Imaging, Biomarkers, Aged
Abstract

BACKGROUND AND PURPOSE: The clinical relevance of cortical microinfarcts has recently been established; however, studies on microinfarcts in the deep gray matter are lacking. We examined the risk factors and MR imaging correlates of microinfarcts in the deep gray matter on 7T MR imaging and their relation to cognitive functioning.\MATERIALS AND METHODS: Within the Second Manifestations of ARTerial disease?Magnetic Resonance (SMART-MR) study, 213 patients (mean age, 68 [SD, 8]?years) had a risk-factor assessment, 7T and 1.5T brain MR imaging, and a cognitive examination. Microinfarcts on 7T MR imaging were defined as lesions of < 5 mm. Regression models were used to examine the age-adjusted associations among risk factors, MR imaging markers, and microinfarcts. Cognitive function was summarized as composite and domain-specific z scores. RESULTS: A total of 47 microinfarcts were found in 28 patients (13%), most commonly in the thalamus. Older age, history of stroke, hypertension, and intima-media thickness were associated with microinfarcts. On 1.5T MR imaging, cerebellar infarcts (relative risk = 2.75; 95% CI, 1.4?5.33) and lacunes in the white (relative risk = 3.28; 95% CI, 3.28?6.04) and deep gray matter (relative risk?= 3.06; 95% CI, 1.75?5.35) were associated with microinfarcts, and on 7T MR imaging cortical microinfarcts (relative risk = 2.33; 95% CI, 1.32?4.13). Microinfarcts were also associated with poorer global cognitive functioning (mean difference in the global z score between patients with multiple microinfarcts versus none = ?0.97; 95% CI, ?1.66 to ?0.28, P = .006) and across all cognitive domains. CONCLUSIONS: Microinfarcts in the deep gray matter on 7T MR imaging were associated with worse cognitive functioning and risk factors and MR imaging markers of small-vessel and large-vessel disease. Our findings suggest that microinfarcts in the deep gray matter may represent a novel imaging marker of vascular brain injury.

Published
2022

21. Patients with diffuse idiopathic skeletal hyperostosis have an increased burden of thoracic aortic calcifications

Author

MS Interne Geneeskunde, Circulatory Health, MS Radiologie, Arts-assistenten Radiologie, Beeldverwerking ISI, MS Orthopaedie Algemeen, Regenerative Medicine and Stem Cells, Cancer, Researchgr. Systems Radiology, Infection & Immunity, Team Medisch, Zorgeenheid Vaatchirurgie Medisch, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 7a, Brain, MS Geriatrie, MS Verloskunde, Child Health, CTC, Neurologen, Nefro Vasculaire Geneeskunde, Interne Geneeskunde Vasculaire, Harlianto, Netanja I., Westerink, Jan, Hol, Marjolein E., Wittenberg, Rianne, Foppen, Wouter, Van Der Veen, Pieternella H., Van Ginneken, Bram, Verlaan, Jorrit Jan, De Jong, P. A., Mohamed Hoesein, Firdaus A.A., Asselbergs, F. W., Nathoe, H. M., De Borst, G. J., Bots, M. L., Geerlings, M. I., Emmelot, M. H., Leiner, T., Lely, A. T., Van Der Kaaij, N. P., Kappelle, L. J., Ruigrok, Y. M., Verhaar, M. C., Visseren, F. L.J., MS Interne Geneeskunde, Circulatory Health, MS Radiologie, Arts-assistenten Radiologie, Beeldverwerking ISI, MS Orthopaedie Algemeen, Regenerative Medicine and Stem Cells, Cancer, Researchgr. Systems Radiology, Infection & Immunity, Team Medisch, Zorgeenheid Vaatchirurgie Medisch, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 7a, Brain, MS Geriatrie, MS Verloskunde, Child Health, CTC, Neurologen, Nefro Vasculaire Geneeskunde, Interne Geneeskunde Vasculaire, Harlianto, Netanja I., Westerink, Jan, Hol, Marjolein E., Wittenberg, Rianne, Foppen, Wouter, Van Der Veen, Pieternella H., Van Ginneken, Bram, Verlaan, Jorrit Jan, De Jong, P. A., Mohamed Hoesein, Firdaus A.A., Asselbergs, F. W., Nathoe, H. M., De Borst, G. J., Bots, M. L., Geerlings, M. I., Emmelot, M. H., Leiner, T., Lely, A. T., Van Der Kaaij, N. P., Kappelle, L. J., Ruigrok, Y. M., Verhaar, M. C., and Visseren, F. L.J.

Published
2022

22. Deep learning body-composition analysis of clinically acquired CT-scans estimates creatinine excretion with high accuracy in patients and healthy individuals

Author

Nefro Vasculaire Geneeskunde, MS Radiologie, Circulatory Health, Cancer, Researchgr. Cardiovasculaire Radiologie, Regenerative Medicine and Stem Cells, CDL Cluster Speciële Diagnostiek, MS Nefrologie, Pieters, Tobias T., Veldhuis, W. B., Moeskops, P., de Vos, B. D., Verhaar, M. C., Haitjema, S., Huitema, A. D.R., Rookmaaker, M. B., Nefro Vasculaire Geneeskunde, MS Radiologie, Circulatory Health, Cancer, Researchgr. Cardiovasculaire Radiologie, Regenerative Medicine and Stem Cells, CDL Cluster Speciële Diagnostiek, MS Nefrologie, Pieters, Tobias T., Veldhuis, W. B., Moeskops, P., de Vos, B. D., Verhaar, M. C., Haitjema, S., Huitema, A. D.R., and Rookmaaker, M. B.

Published
2022

23. Residual cardiovascular risk reduction guided by lifetime benefit estimation in patients with symptomatic atherosclerotic disease: Effectiveness and cost-effectiveness

Author

Interne Geneeskunde Vasculaire, MS Interne Geneeskunde, Circulatory Health, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CCU Cardiologie, Team Medisch, HEE, Zorgeenheid Vaatchirurgie Medisch, Brain, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 7a, MS Geriatrie, Researchgr. Systems Radiology, Infection & Immunity, Cancer, MS Radiologie, MS Verloskunde, Child Health, CTC, Neurologen, Nefro Vasculaire Geneeskunde, Hageman, Steven H.J., Dorresteijn, Jannick A.N., Bots, Michiel L., Asselbergs, F. W., Westerink, Jan, Van Der Meulen, Miriam P., Mosterd, Arend, Visseren, F. L.J., Nathoe, H. M., De Borst, G. J., Geerlings, M. I., Emmelot, M. H., De Jong, P. A., Leiner, T., Lely, A. T., Van Der Kaaij, N. P., Kappelle, L. J., Ruigrok, Y. M., Verhaar, M. C., Interne Geneeskunde Vasculaire, MS Interne Geneeskunde, Circulatory Health, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CCU Cardiologie, Team Medisch, HEE, Zorgeenheid Vaatchirurgie Medisch, Brain, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 7a, MS Geriatrie, Researchgr. Systems Radiology, Infection & Immunity, Cancer, MS Radiologie, MS Verloskunde, Child Health, CTC, Neurologen, Nefro Vasculaire Geneeskunde, Hageman, Steven H.J., Dorresteijn, Jannick A.N., Bots, Michiel L., Asselbergs, F. W., Westerink, Jan, Van Der Meulen, Miriam P., Mosterd, Arend, Visseren, F. L.J., Nathoe, H. M., De Borst, G. J., Geerlings, M. I., Emmelot, M. H., De Jong, P. A., Leiner, T., Lely, A. T., Van Der Kaaij, N. P., Kappelle, L. J., Ruigrok, Y. M., and Verhaar, M. C.

Published
2022

24. Patients with diffuse idiopathic skeletal hyperostosis have an increased burden of thoracic aortic calcifications

Author

Harlianto, Netanja I., Westerink, Jan, Hol, Marjolein E., Wittenberg, Rianne, Foppen, Wouter, van der Veen, Pieternella H., van Ginneken, Bram, Verlaan, Jorrit-Jan, de Jong, Pim A., Mohamed Hoesein, Firdaus A. A., Asselbergs, F. W., Nathoe, H. M., de Borst, G. J., Bots, M. L., Geerlings, M. I., Emmelot, M. H., de Jong, P. A., Leiner, T., Lely, A. T., van der Kaaij, N. P., Kappelle, L. J., Ruigrok, Y. M., Verhaar, M. C., Visseren, F. L. J., General practice, APH - Personalized Medicine, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Amsterdam Neuroscience - Neurodegeneration, and APH - Aging & Later Life

Subjects
calcification, All institutes and research themes of the Radboud University Medical Center, Rheumatology, thoracic aortic calcification, atherosclerosis, diffuse idiopathic skeletal hyperostosis, Rare cancers Radboud Institute for Health Sciences [Radboudumc 9], bone formation
Abstract

Objectives. DISH has been associated with increased coronary artery calcifications and incident ischaemic stroke. The formation of bone along the spine may share pathways with calcium deposition in the aorta. We hypothesized that patients with DISH have increased vascular calcifications. Therefore we aimed to investigate the presence and extent of DISH in relation to thoracic aortic calcification (TAC) severity. Methods. This cross-sectional study included 4703 patients from the Second Manifestation of ARTerial disease cohort, consisting of patients with cardiovascular events or risk factors for cardiovascular disease. Chest radiographs were scored for DISH using the Resnick criteria. Different severities of TAC were scored arbitrarily from no TAC to mild, moderate or severe TAC. Using multivariate logistic regression, the associations between DISH and TAC were analysed with adjustments for age, sex, BMI, diabetes, smoking status, non-high-density lipoprotein cholesterol, cholesterol lowering drug usage, renal function and blood pressure. Results. A total of 442 patients (9.4%) had evidence of DISH and 1789 (38%) patients had TAC. The prevalence of DISH increased from 6.6% in the no TAC group to 10.8% in the mild, 14.3% in the moderate and 17.1% in the severe TAC group. After adjustments, DISH was significantly associated with the presence of TAC [odds ratio (OR) 1.46 [95% CI 1.17, 1.82)]. In multinomial analyses, DISH was associated with moderate TAC [OR 1.43 (95% CI 1.06, 1.93)] and severe TAC [OR 1.67 (95% CI 1.19, 2.36)]. Conclusions. Subjects with DISH have increased TACs, providing further evidence that patients with DISH have an increased burden of vascular calcifications.

Published
2022

28. Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations

Author

Afd Pharmacoepi & Clinical Pharmacology, Interne geneeskunde GD, dCSCA AVR, Sub Inorganic Chemistry and Catalysis, LS Vertaalwetenschap, CS_Genetics, Pei, J, Schuldt, M, Nagyova, E, Gu, Z, El Bouhaddani, S, Yiangou, L, Jansen, M, Calis, J J A, Dorsch, L M, Blok, C Snijders, van den Dungen, N A M, Lansu, N, Boukens, B J, Efimov, I R, Michels, M, Verhaar, M C, de Weger, R, Vink, A, van Steenbeek, F G, Baas, A F, Davis, R P, Uh, H W, Kuster, D W D, Cheng, C, Mokry, M, van der Velden, J, Asselbergs, F W, Harakalova, M, Afd Pharmacoepi & Clinical Pharmacology, Interne geneeskunde GD, dCSCA AVR, Sub Inorganic Chemistry and Catalysis, LS Vertaalwetenschap, CS_Genetics, Pei, J, Schuldt, M, Nagyova, E, Gu, Z, El Bouhaddani, S, Yiangou, L, Jansen, M, Calis, J J A, Dorsch, L M, Blok, C Snijders, van den Dungen, N A M, Lansu, N, Boukens, B J, Efimov, I R, Michels, M, Verhaar, M C, de Weger, R, Vink, A, van Steenbeek, F G, Baas, A F, Davis, R P, Uh, H W, Kuster, D W D, Cheng, C, Mokry, M, van der Velden, J, Asselbergs, F W, and Harakalova, M

Published
2021

29. GFR estimation is complicated by a high incidence of non-steady-state serum creatinine concentrations at the emergency department

Author

CDL Upod, Nefro Vasculaire Geneeskunde, CDL Arcadia, Circulatory Health, Regenerative Medicine and Stem Cells, MS Nefrologie, Centraal Diagnostisch Laboratorium, CDL Staf Patiëntenzorg KC, Niemantsverdriet, M. S.A., Pieters, T. T., Hoefer, I. E., Verhaar, M. C., Joles, J. A., van Solinge, W. W., Tiel Groenestege, W. M., Haitjema, S., Rookmaaker, M. B., CDL Upod, Nefro Vasculaire Geneeskunde, CDL Arcadia, Circulatory Health, Regenerative Medicine and Stem Cells, MS Nefrologie, Centraal Diagnostisch Laboratorium, CDL Staf Patiëntenzorg KC, Niemantsverdriet, M. S.A., Pieters, T. T., Hoefer, I. E., Verhaar, M. C., Joles, J. A., van Solinge, W. W., Tiel Groenestege, W. M., Haitjema, S., and Rookmaaker, M. B.

Published
2021

30. Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations

Author

Onderzoek Precision medicine, Other research (not in main researchprogram), Biostatistiek Onderzoek, Genetica Klinische Genetica, Immuno/reuma onderzoek 5 (Vastert2), CMM Groep Cuppen, Unit Opleiding Aios, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, Pathologie Laboratorium diagnostiek, Pathologie Pathologen staf, JC onderzoeksprogramma Methodologie, Onderzoek, Child Health, Team Medisch, Pei, J, Schuldt, M, Nagyova, E, Gu, Z, El Bouhaddani, S, Yiangou, L, Jansen, M, Calis, J J A, Dorsch, L M, Blok, C Snijders, van den Dungen, N A M, Lansu, N, Boukens, B J, Efimov, I R, Michels, M, Verhaar, M C, de Weger, R, Vink, A, van Steenbeek, F G, Baas, A F, Davis, R P, Uh, H W, Kuster, D W D, Cheng, C, Mokry, M, van der Velden, J, Asselbergs, F W, Harakalova, M, Onderzoek Precision medicine, Other research (not in main researchprogram), Biostatistiek Onderzoek, Genetica Klinische Genetica, Immuno/reuma onderzoek 5 (Vastert2), CMM Groep Cuppen, Unit Opleiding Aios, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, Pathologie Laboratorium diagnostiek, Pathologie Pathologen staf, JC onderzoeksprogramma Methodologie, Onderzoek, Child Health, Team Medisch, Pei, J, Schuldt, M, Nagyova, E, Gu, Z, El Bouhaddani, S, Yiangou, L, Jansen, M, Calis, J J A, Dorsch, L M, Blok, C Snijders, van den Dungen, N A M, Lansu, N, Boukens, B J, Efimov, I R, Michels, M, Verhaar, M C, de Weger, R, Vink, A, van Steenbeek, F G, Baas, A F, Davis, R P, Uh, H W, Kuster, D W D, Cheng, C, Mokry, M, van der Velden, J, Asselbergs, F W, and Harakalova, M

Published
2021

31. GeNepher: building a data- and biobank for (suspected) hereditary renal disease

Author

Claus, L. R., Boulogne, F., Lilien, M. R., Rookmaaker, M. B., van der Zwaag, A., Nguyen, T. Q., Verhaar, M. C., Knoers, N. V. A. M., Deelen, P., Franke, L., de Borst, M. H., van Eerde, A. M., Stem Cell Aging Leukemia and Lymphoma (SALL), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Groningen Institute for Organ Transplantation (GIOT), and Groningen Kidney Center (GKC)

Published
2020

32. Residual cardiovascular risk reduction guided by lifetime benefit estimation in patients with symptomatic atherosclerotic disease: effectiveness and cost-effectiveness

Author

Hageman, Steven H J, primary, Dorresteijn, Jannick A N, additional, Bots, Michiel L, additional, Asselbergs, Folkert W, additional, Westerink, Jan, additional, van der Meulen, Miriam P, additional, Mosterd, Arend, additional, Visseren, Frank L J, additional, Asselbergs, F W, additional, Nathoe, H M, additional, de Borst, G J, additional, Bots, M L, additional, Geerlings, M I, additional, Emmelot, M H, additional, de Jong, P A, additional, Leiner, T, additional, Lely, A T, additional, van der Kaaij, N P, additional, Kappelle, L J, additional, Ruigrok, Y M, additional, Verhaar, M C, additional, Visseren, F L J, additional, and Westerink, J, additional

Published
2021
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35. The association between chronic kidney disease, falls, and fractures: a systematic review and meta-analysis

Author

Unit Opleiding Geriatrie, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, MS Geriatrie, Goto, N A, Weststrate, A C G, Oosterlaan, F M, Verhaar, M C, Willems, H C, Emmelot-Vonk, M H, Hamaker, M E, Unit Opleiding Geriatrie, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, MS Geriatrie, Goto, N A, Weststrate, A C G, Oosterlaan, F M, Verhaar, M C, Willems, H C, Emmelot-Vonk, M H, and Hamaker, M E

Published
2020

42. The effect of computerized decision support systems on cardiovascular risk factors: a systematic review and meta-analysis

Author

Groenhof, T. Katrien J., Asselbergs, Folkert W., Groenwold, Rolf H. H., Grobbee, Diederick E., Visseren, Frank L. J., Bots, Michiel L., Nathoe, H. M., de Borst, G. J., Geerlings, M. I., Emmelot, M. H., de Jong, P. A., Leiner, T., Lely, A. T., van der Kaaij, N. P., Kappelle, L. J., Ruigrok, Y. M., Verhaar, M. C., and Westerink, J.

Subjects
medicine.medical_specialty, 020205 medical informatics, Health Informatics, Cardiovascular risk management, 02 engineering and technology, Disease, lcsh:Computer applications to medicine. Medical informatics, Research Support, Clinical decision support system, Health informatics, 03 medical and health sciences, 0302 clinical medicine, Journal Article, 0202 electrical engineering, electronic engineering, information engineering, Medicine, Humans, 030212 general & internal medicine, Medical Informatics Applications, Risk factor, Non-U.S. Gov't, Intensive care medicine, Risk management, Risk Management, business.industry, Research Support, Non-U.S. Gov't, Health Policy, Medical record, Computerized decision support, Decision Support Systems, Clinical, Computer Science Applications, Cardiovascular Diseases, Meta-analysis, Relative risk, lcsh:R858-859.7, CDSS, business, Research Article
Abstract

Background Cardiovascular risk management (CVRM) is notoriously difficult because of multi-morbidity and the different phenotypes and severities of cardiovascular disease. Computerized decision support systems (CDSS) enable the clinician to integrate the latest scientific evidence and patient information into tailored strategies. The effect on cardiovascular risk factor management is yet to be confirmed. Methods We performed a systematic review and meta-analysis evaluating the effects of CDSS on CVRM, defined as the change in absolute values and attainment of treatment goals of systolic blood pressure (SBP), low density lipoprotein cholesterol (LDL-c) and HbA1c. Also, CDSS characteristics related to more effective CVRM were identified. Eligible articles were methodologically appraised using the Cochrane risk of bias tool. We calculated mean differences, relative risks, and if appropriate (I2

Published
2019

46. Effect of Donor Variation on Osteogenesis and Vasculogenesis in Hydrogel Co-cultures

Author

Pennings, I, van Dijk, L A, van Huuksloot, J, Fledderus, J O, Schepers, K, Braat, A K, Hsiao, E C, Barruet, E, Morales, B M, Verhaar, M C, Rosenberg, A J W P, Gawlitta, D, Pennings, I, van Dijk, L A, van Huuksloot, J, Fledderus, J O, Schepers, K, Braat, A K, Hsiao, E C, Barruet, E, Morales, B M, Verhaar, M C, Rosenberg, A J W P, and Gawlitta, D

Published
2019

47. Effect of Donor Variation on Osteogenesis and Vasculogenesis in Hydrogel Co-cultures

Author

MKA/BT Onderzoek, Other research (not in main researchprogram), MS Nefrologie, CMM Groep Coffer, MS Radiologie, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, Zorgeenheid MKA/BT Medisch, Pennings, I, van Dijk, L A, van Huuksloot, J, Fledderus, J O, Schepers, K, Braat, A K, Hsiao, E C, Barruet, E, Morales, B M, Verhaar, M C, Rosenberg, A J W P, Gawlitta, D, MKA/BT Onderzoek, Other research (not in main researchprogram), MS Nefrologie, CMM Groep Coffer, MS Radiologie, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, Zorgeenheid MKA/BT Medisch, Pennings, I, van Dijk, L A, van Huuksloot, J, Fledderus, J O, Schepers, K, Braat, A K, Hsiao, E C, Barruet, E, Morales, B M, Verhaar, M C, Rosenberg, A J W P, and Gawlitta, D

Published
2019

48. Quality of life after the initiation of dialysis or maximal conservative management in elderly patients: a longitudinal analysis of the Geriatric assessment in OLder patients starting Dialysis (GOLD) study

Author

Unit Opleiding Aios, Unit Opleiding Geriatrie, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, van Loon, I N, Goto, N A, Boereboom, F T J, Verhaar, M C, Bots, M L, Hamaker, M E, Unit Opleiding Aios, Unit Opleiding Geriatrie, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, van Loon, I N, Goto, N A, Boereboom, F T J, Verhaar, M C, Bots, M L, and Hamaker, M E

Published
2019

49. Thoracic vertebral fractures and hyperkyphosis in elderly patients with end-stage kidney disease; do these patients have different clinical outcomes?

Author

Unit Opleiding Geriatrie, Unit Opleiding Aios, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, MS Geriatrie, Goto, N. A., Koele, M. C., van Loon, I. N., Boereboom, F. T. J., Verhaar, M. C., Emmelot-Vonk, M. H., Hamaker, M. E., Willems, H. C., Unit Opleiding Geriatrie, Unit Opleiding Aios, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, MS Geriatrie, Goto, N. A., Koele, M. C., van Loon, I. N., Boereboom, F. T. J., Verhaar, M. C., Emmelot-Vonk, M. H., Hamaker, M. E., and Willems, H. C.

Published
2019

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