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2. Value of Serial Multiparametric Magnetic Resonance Imaging and Magnetic Resonance Imaging–guided Biopsies in Men with Low-risk Prostate Cancer on Active Surveillance After 1 Yr Follow-up

Author

Hamoen, Esther Hendrika Johanna, Hoeks, Caroline M.A., Somford, Diederik M., van Oort, Inge M., Vergunst, Henk, Oddens, Jorg R., Smits, Geert A., Bokhorst, Leonard P., Witjes, J. Alfred, Rovers, Maroeska M., Hulsbergen-van de Kaa, Christina A., and Barentsz, Jelle O.

Published
2019
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21. Value of Serial Multiparametric Magnetic Resonance Imaging and Magnetic Resonance Imaging-guided Biopsies in Men with Low-risk Prostate Cancer on Active Surveillance After 1 Yr Follow-up

Author

Hamoen, E.H.J., Hoeks, C.M.A., Somford, D.M., Oort, Inge M. van, Vergunst, Henk, Oddens, Jorg R., Witjes, J.A., Rovers, M.M., Hulsbergen-van de Kaa, C.A., Barentsz, J.O., Hamoen, E.H.J., Hoeks, C.M.A., Somford, D.M., Oort, Inge M. van, Vergunst, Henk, Oddens, Jorg R., Witjes, J.A., Rovers, M.M., Hulsbergen-van de Kaa, C.A., and Barentsz, J.O.

Abstract

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Published
2019

23. Functional and oncological outcomes of salvage cryosurgery for radiorecurrent prostate cancer.

Author

Exterkate, Leonie, Peters, Max, Somford, Diederik M., and Vergunst, Henk

Subjects
FUNCTIONAL assessment, CRYOSURGERY, OVERALL survival, URINARY fistula, PROSTATE-specific antigen, PROSTATE cancer, URINARY incontinence
Abstract

Objectives: To evaluate the oncological and functional outcomes of salvage cryosurgery (SCS) for radiorecurrent prostate cancer (rrPCa). Patients and Methods: A total of 169 consecutive patients with biopsy confirmed rrPCa were retrospectively analysed. All patients underwent SCS in a single referral centre between 2006 and 2018. The primary outcome was biochemical recurrence‐free survival (BRFS) according to the Phoenix definition (prostate‐specific antigen [PSA] nadir +2 ng/mL). The secondary outcomes were overall survival, BRFS defined as a PSA level of >0.5 ng/mL, metastasis‐free survival, androgen‐deprivation therapy (ADT)‐free survival, and functional outcomes. Complications were classified according to the Clavien–Dindo system. PSA was measured every 3–6 months postoperatively. Functional outcomes were scored as reported by patients at outpatient visits. Kaplan–Meier survival analysis and uni‐ and multivariable Cox regression were performed. Results: The median (interquartile range) follow‐up was 36 (18–66) months. The BRFS after 5 and 8 years was 52% (95% confidence interval [CI] 43–62%) and 45% (95% CI 35–57%), respectively. At multivariable analysis PSA level at initial diagnosis, initial treatment, interval between primary treatment and SCS, age at SCS, and post‐SCS PSA nadir were significant factors for BRFS. The 5‐year ADT‐free survival was 70% (95% CI 62–79%). Clavien–Dindo Grade ≥III complications occurred in 1.2% (two/169) of patients. In all, 19% (29/156) of patients had new‐onset urinary incontinence defined as >1 pad/24 h and 92% (57/62) of patients had new‐onset erectile dysfunction. Persistent urinary fistula occurred in 6.5% (11/169) of patients. Conclusions: The present study shows acceptable oncological outcomes of SCS considering the salvage character of the treatment. The occurrence of serious complications such as urinary incontinence and fistula should not be underestimated. [ABSTRACT FROM AUTHOR]

Published
2021
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25. Detection of High-grade Prostate Cancer Using a Urinary Molecular Biomarker–Based Risk Score

Author

Van Neste, Leander, primary, Hendriks, Rianne J., additional, Dijkstra, Siebren, additional, Trooskens, Geert, additional, Cornel, Erik B., additional, Jannink, Sander A., additional, de Jong, Hans, additional, Hessels, Daphne, additional, Smit, Frank P., additional, Melchers, Willem J.G., additional, Leyten, Gisèle H.J.M., additional, de Reijke, Theo M., additional, Vergunst, Henk, additional, Kil, Paul, additional, Knipscheer, Ben C., additional, Hulsbergen-van de Kaa, Christina A., additional, Mulders, Peter F.A., additional, van Oort, Inge M., additional, Van Criekinge, Wim, additional, and Schalken, Jack A., additional

Published
2016
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26. The AVOCAT study: Bicalutamide monotherapy versus combined bicalutamide plus dutasteride therapy for patients with locally advanced or metastatic carcinoma of the prostate—a long-term follow-up comparison and quality of life analysis

Author

Dijkstra, Siebren, primary, Witjes, Wim P. J., additional, Roos, Erik P. M., additional, Vijverberg, Peter L. M., additional, Geboers, Arno D. H., additional, Bruins, Jos L., additional, Smits, Geert A. H. J., additional, Vergunst, Henk, additional, and Mulders, Peter F. A., additional

Published
2016
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27. MP02-02 MULTICENTER VALIDATION STUDY OF A MOLECULAR URINE TEST TO PREDICT HIGH-GRADE PROSTATE CANCER.

Author

Hendriks, Rianne, primary, Dijkstra, Siebren, additional, Cornel, Erik, additional, Jannink, Sander, additional, de Jong, Hans, additional, Hessels, Daphne, additional, Smit, Frank, additional, Melchers, Willem, additional, Leyten, Gisele, additional, De Reijke, Theo, additional, Vergunst, Henk, additional, Kil, Paul, additional, Knipscheer, Ben, additional, Hulsbergen-van de Kaa, Christina, additional, Mulders, Peter, additional, Van Oort, Inge, additional, and Schalken, Jack, additional

Published
2016
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28. Elevated HOXC6/DLX1 mRNA biomarker levels in urine to help select patients at increased risk for high-grade prostate cancer detection upon prostate biopsy.

Author

Hendriks, Rianne, primary, Dijkstra, Siebren, additional, Cornel, Erik Bastiaan, additional, Jannink, Sander, additional, de Jong, Hans, additional, Hessels, Daphne, additional, Melchers, Willem, additional, Smit, Frank, additional, Leyten, Gisele, additional, De Reijke, Theo, additional, Vergunst, Henk, additional, Kil, Paul, additional, Knipscheer, Ben, additional, Hulsbergen-van de Kaa, Christina, additional, Mulders, Peter, additional, Van Oort, Inge, additional, and Schalken, Jack, additional

Published
2016
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29. Identification of a Candidate Gene Panel for the Early Diagnosis of Prostate Cancer

Author

Leyten, Gisele H.J.M., primary, Hessels, Daphne, additional, Smit, Frank P., additional, Jannink, Sander A., additional, de Jong, Hans, additional, Melchers, Willem J.G., additional, Cornel, Erik B., additional, de Reijke, Theo M., additional, Vergunst, Henk, additional, Kil, Paul, additional, Knipscheer, Ben C., additional, Hulsbergen-van de Kaa, Christina A., additional, Mulders, Peter F.A., additional, van Oort, Inge M., additional, and Schalken, Jack A., additional

Published
2015
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31. Value of 3-T Multiparametric Magnetic Resonance Imaging and Magnetic Resonance–Guided Biopsy for Early Risk Restratification in Active Surveillance of Low-Risk Prostate Cancer

Author

Hoeks, Caroline M.A., primary, Somford, Diederik M., additional, van Oort, Inge M., additional, Vergunst, Henk, additional, Oddens, Jorg R., additional, Smits, Geert A., additional, Roobol, Monique J., additional, Bul, Meelan, additional, Hambrock, Thomas, additional, Witjes, J. Alfred, additional, Fütterer, Jurgen J., additional, Hulsbergen-van de Kaa, Christina A., additional, and Barentsz, Jelle O., additional

Published
2014
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32. Prospective Multicentre Evaluation of PCA3 and TMPRSS2-ERG Gene Fusions as Diagnostic and Prognostic Urinary Biomarkers for Prostate Cancer

Author

Leyten, Gisele H.J.M., primary, Hessels, Daphne, additional, Jannink, Sander A., additional, Smit, Frank P., additional, de Jong, Hans, additional, Cornel, Erik B., additional, de Reijke, Theo M., additional, Vergunst, Henk, additional, Kil, Paul, additional, Knipscheer, Ben C., additional, van Oort, Inge M., additional, Mulders, Peter F.A., additional, Hulsbergen-van de Kaa, Christina A., additional, and Schalken, Jack A., additional

Published
2014
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34. Active Surveillance for Low-Risk Prostate Cancer Worldwide: The PRIAS Study

Author

Bul, Meelan, primary, Zhu, Xiaoye, additional, Valdagni, Riccardo, additional, Pickles, Tom, additional, Kakehi, Yoshiyuki, additional, Rannikko, Antti, additional, Bjartell, Anders, additional, van der Schoot, Deric K., additional, Cornel, Erik B., additional, Conti, Giario N., additional, Boevé, Egbert R., additional, Staerman, Frédéric, additional, Vis-Maters, Jenneke J., additional, Vergunst, Henk, additional, Jaspars, Joris J., additional, Strölin, Petra, additional, van Muilekom, Erik, additional, Schröder, Fritz H., additional, Bangma, Chris H., additional, and Roobol, Monique J., additional

Published
2013
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35. Evaluation of Diffusion-Weighted MR Imaging at Inclusion in an Active Surveillance Protocol for Low-Risk Prostate Cancer

Author

Somford, Diederik M., primary, Hoeks, Caroline M., additional, Hulsbergen-van de Kaa, Christina A., additional, Hambrock, Thomas, additional, Fütterer, Jurgen J., additional, Witjes, J. Alfred, additional, Bangma, Chris H., additional, Vergunst, Henk, additional, Smits, Geert A., additional, Oddens, Jorg R., additional, van Oort, Inge M., additional, and Barentsz, Jelle O., additional

Published
2013
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36. Does a decision aid for prostate cancer affect different aspects of decisional regret, assessed with new regret scales? A randomized, controlled trial.

Author

Tol‐Geerdink, Julia J., Leer, Jan Willem H., Wijburg, Carl J., Oort, Inge M., Vergunst, Henk, Lin, Emile J., Witjes, J. Alfred, and Stalmeier, Peep F. M.

Subjects
ANALYSIS of variance, CHI-squared test, PATIENT education, PROBABILITY theory, PROSTATE tumors, PROSTATECTOMY, QUESTIONNAIRES, RADIOISOTOPE brachytherapy, RADIOTHERAPY, RESEARCH evaluation, STATISTICAL sampling, T-test (Statistics), RANDOMIZED controlled trials, TREATMENT effectiveness, PATIENTS' attitudes, PATIENT decision making
Abstract

Objective: To develop and validate new regret scales and examine whether a decision aid affects different aspects of regret in the treatment choice for prostate cancer. Methods: This was a multicentre trial (three sites) with imbalanced randomization (1 : 2). From 2008 to 2011, patients with localized prostate cancer were randomized 1 : 2 to usual care (N = 77) or usual care plus a decision aid presenting risks and benefits of different treatments (N = 163). The treatments were surgery and (external or interstitial) radiotherapy. Regret was assessed before, and 6 and 12 months after treatment, using the Decisional regret scale by Brehaut et al. (Medical Decision Making, 23, 2003, 281), and three new scales focusing on process, option and outcome regret. The relation between decision aid and regret was analysed by anova. Results: The concurrent validity of the new regret scales was confirmed by correlations between regret and anxiety, depression, decision evaluation scales and health‐related quality of life. With a decision aid, patient participation was increased (P = 0.002), but regret was not. If anything, in patients with serious morbidity the decision aid resulted in a trend to less option regret and less Brehaut regret (P = 0.075 and P = 0.061, with effect sizes of 0.35 and 0.38, respectively). Exploratory analyses suggest that high‐risk patients benefitted most from the decision aid. Conclusion: The new regret scales may be of value in distinguishing separate aspects of regret. In general, regret was not affected by the decision aid. In patients with serious morbidity, a trend to lower option regret with a decision aid was observed. [ABSTRACT FROM AUTHOR]

Published
2016
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37. Three-Tesla Magnetic Resonance–Guided Prostate Biopsy in Men With Increased Prostate-Specific Antigen and Repeated, Negative, Random, Systematic, Transrectal Ultrasound Biopsies: Detection of Clinically Significant Prostate Cancers

Author

Hoeks, Caroline M.A., primary, Schouten, Martijn G., additional, Bomers, Joyce G.R., additional, Hoogendoorn, Stefan P., additional, Hulsbergen-van de Kaa, Christina A., additional, Hambrock, Thomas, additional, Vergunst, Henk, additional, Sedelaar, J.P. Michiel, additional, Fütterer, Jurgen J., additional, and Barentsz, Jelle O., additional

Published
2012
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38. Patterns of outcome and toxicity after salvage prostatectomy, salvage cryosurgery and salvage brachytherapy for prostate cancer recurrences after radiation therapy: a multi-center experience and literature review

Author

Peters, Max, primary, Moman, Maaike R., additional, van der Poel, Henk G., additional, Vergunst, Henk, additional, de Jong, Igle Jan, additional, Vijverberg, Peter L. M., additional, Battermann, Jan J., additional, Horenblas, Simon, additional, and van Vulpen, Marco, additional

Published
2012
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40. 2104 PROSPECTIVE MULTICENTER EVALUATION OF PCA3 AND TMPRSS2-ERG GENE FUSIONS AS DIAGNOSTIC AND PROGNOSTIC BIOMARKERS FOR PROSTATE CANCER

Author

Leyten, Gisele, primary, Hessels, Daphne, additional, Cornel, Erik, additional, de Reyke, Theo, additional, Vergunst, Henk, additional, Kil, Paul, additional, Knipscheer, Ben, additional, Jannink, Sander, additional, Smit, Frank, additional, de Jong, Hans, additional, van Oort, Inge, additional, Mulders, Peter, additional, and Schalken, Jack, additional

Published
2012
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41. Value of multimodality MRI and MR-guided biopsy at inclusion in an active surveillance protocol for prostate cancer.

Author

Somford, Diederik Meindert, primary, Hoeks, Caroline M., additional, van den Bergh, Roderick C., additional, Vergunst, Henk, additional, van Oort, Inge M, additional, Smits, Geert A., additional, Oddens, Jorg R., additional, Hulsbergen - van de Kaa, Christina A, additional, Bangma, Chris H., additional, Witjes, J. Alfred, additional, and Barentsz, Jelle O., additional

Published
2012
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42. Feasibility of 3T Dynamic Contrast-Enhanced Magnetic Resonance-Guided Biopsy in Localizing Local Recurrence of Prostate Cancer After External Beam Radiation Therapy

Author

Yakar, Derya, primary, Hambrock, Thomas, additional, Huisman, Henkjan, additional, Hulsbergen-van de Kaa, Christina A., additional, van Lin, Emile, additional, Vergunst, Henk, additional, Hoeks, Caroline M.A., additional, van Oort, Inge M., additional, Witjes, J Alfred, additional, Barentsz, Jelle O., additional, and Fütterer, Jurgen J., additional

Published
2010
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44. Sequence variant on 8q24 confers susceptibility to urinary bladder cancer

Author

Kiemeney, Lambertus A, primary, Thorlacius, Steinunn, additional, Sulem, Patrick, additional, Geller, Frank, additional, Aben, Katja K H, additional, Stacey, Simon N, additional, Gudmundsson, Julius, additional, Jakobsdottir, Margret, additional, Bergthorsson, Jon T, additional, Sigurdsson, Asgeir, additional, Blondal, Thorarinn, additional, Witjes, J Alfred, additional, Vermeulen, Sita H, additional, Hulsbergen-van de Kaa, Christina A, additional, Swinkels, Dorine W, additional, Ploeg, Martine, additional, Cornel, Erik B, additional, Vergunst, Henk, additional, Thorgeirsson, Thorgeir E, additional, Gudbjartsson, Daniel, additional, Gudjonsson, Sigurjon A, additional, Thorleifsson, Gudmar, additional, Kristinsson, Kari T, additional, Mouy, Magali, additional, Snorradottir, Steinunn, additional, Placidi, Donatella, additional, Campagna, Marcello, additional, Arici, Cecilia, additional, Koppova, Kvetoslava, additional, Gurzau, Eugene, additional, Rudnai, Peter, additional, Kellen, Eliane, additional, Polidoro, Silvia, additional, Guarrera, Simonetta, additional, Sacerdote, Carlotta, additional, Sanchez, Manuel, additional, Saez, Berta, additional, Valdivia, Gabriel, additional, Ryk, Charlotta, additional, de Verdier, Petra, additional, Lindblom, Annika, additional, Golka, Klaus, additional, Bishop, D Timothy, additional, Knowles, Margaret A, additional, Nikulasson, Sigfus, additional, Petursdottir, Vigdis, additional, Jonsson, Eirikur, additional, Geirsson, Gudmundur, additional, Kristjansson, Baldvin, additional, Mayordomo, Jose I, additional, Steineck, Gunnar, additional, Porru, Stefano, additional, Buntinx, Frank, additional, Zeegers, Maurice P, additional, Fletcher, Tony, additional, Kumar, Rajiv, additional, Matullo, Giuseppe, additional, Vineis, Paolo, additional, Kiltie, Anne E, additional, Gulcher, Jeffrey R, additional, Thorsteinsdottir, Unnur, additional, Kong, Augustine, additional, Rafnar, Thorunn, additional, and Stefansson, Kari, additional

Published
2008
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45. Choice between prostatectomy and radiotherapy when men are eligible for both: a randomized controlled trial of usual care vs decision aid.

Author

Tol‐Geerdink, Julia J., Willem Leer, Jan, Weijerman, Philip C., Oort, Inge M., Vergunst, Henk, Lin, Emile N., Alfred Witjes, J., and Stalmeier, Peep F.

Subjects
PROSTATECTOMY, RADIOTHERAPY, PROSTATE cancer treatment, MEDICAL decision making, PATIENT participation, RADIOISOTOPE brachytherapy, RANDOMIZED controlled trials
Abstract

What's known on the subject? and What does the study add? Many patients are eligible for more than one treatment option for prostate cancer. In usual care, urologists have a large influence on the treatment choice. Decision aids, providing balanced information on the pros and cons of different treatment options, improve the match between patient preferences and treatment received., In men eligible for both surgery and external beam radiotherapy, treatment choice differed by hospital. Across the participating hospitals, the decision aid consistently led to fewer patients remaining undecided on their treatment preference and more patients choosing brachytherapy., Objectives To examine the treatment choice for localized prostate cancer in selected men who were eligible for both prostatectomy and radiotherapy., To examine whether increased patient participation, using a decision aid, affected the treatment choice., Patients and Methods From 2008 to 2011, 240 patients with localized prostate cancer were enrolled from three separate hospitals., They were selected to be eligible for both prostatectomy and external beam radiotherapy. Brachytherapy was a third option for about half of the patients., In this randomized controlled trial, patients were randomized to a group which only discussed their treatment with their specialist (usual care group) and a group which received additional information from a decision aid presented by a researcher (decision aid group). The decision aid was based on a literature review., Predictors of treatment choice were examined., Results Treatment choice was affected by the decision aid ( P = 0.03) and by the hospital of intake ( P < 0.001)., The decision aid led to more patients choosing brachytherapy ( P = 0.02) and fewer patients remaining undecided ( P < 0.05)., Prostatectomy remained the most frequently preferred treatment., Age, tumour characteristics or pretreatment urinary, bowel or erectile functioning did not affect the choice in this selected group., Patients choosing brachytherapy assigned more weight to convenience of the procedure and to maintaining erectile function., Conclusions Traditionally, patient characteristics differ between surgery and radiotherapy groups, but not in this selected group of patients., Men eligible for both prostatectomy and radiotherapy mostly preferred prostatectomy, and the treatment choice was influenced by the hospital they visited., Giving patients evidence-based information, by means of a decision aid, led to an increase in brachytherapy. [ABSTRACT FROM AUTHOR]

Published
2013
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50. Electromagnetic Shock Wave Lithotripsy of Gallbladder Stones: A Wide Range of Inclusion Criteria.

Author

Den Toom, René, Vergunst, Henk, Nijs, Huub G. T., Brakel, Koen, Laméris, Johan S., and Terpstra, Onno T.

Subjects
GALLBLADDER, LITHOTRIPSY, BILE acids, PANCREATITIS, BILIARY tract, CALCULI, SURGERY, CHOLAGOGUES
Abstract

From April 1988 until November 1990, 83 patients with symptomatic gallbladder stones were treated in the University Hospital "Dijkzigt" Rotterdam with extracorporeal shock wave lithotripsy (ESWL) followed by oral administration of bile acids (urso- and chenodeoxycholic acid). According to our inclusion criteria, patients with up to 10 stones without any limit to the size of the stone(s) were accepted for treatment. On average, these patients underwent two sessions of ESWL with an electromagnetic lithotriptor (Lithostar and Lithostar Plus, Siemens AG, Erlangen, Germany). Fragmentation of stones was achieved in 70/83 (84% patients). The best results were achieved in patients with a solitary gallstone (50% of these patients were stone-free 12 months after ESWL). Four percent of the patients with two to three stones, and 12% of the patients with four to 10 stones were free of stones 12 months after ESWL. Twenty-eight (34%) patients suffered from biliary colics after ESWL, and three patients (3.5%) developed pan-creatitis. The administration of oral bile acids was complicated by transient diarrhoea in 15 (18%) patients. ESWL followed by oral bile acid therapy is a relatively effective and safe therapy for a highly select population of patients with gallbladder stones, which can be performed on an outpatient basis. Although the results for multiple stones were poor, the usage of wide inclusion criteria (up to 10 stones of any size) did not affect the success rate of ESWL for multiple stones. [ABSTRACT FROM AUTHOR]

Published
1992

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