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1. Amyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal Dominant Alzheimer’s Disease

Author

Allegri, Ricardo, Amtashar, Fatima, Bateman, Randy, Benzinger, Tammie, Berman, Sarah, Bodge, Courtney, Brandon, Susan, Brooks, William (Bill), Buck, Jill, Buckles, Virginia, Chea, Sochenda, Chhatwal, Jasmeer, Chrem, Patricio, Chui, Helena, Cinco, Jake, Clifford, Jack, Cruchaga, Carlos, D‘Mello, Mirelle, Donahue, Tamara, Douglas, Jane, Edigo, Noelia, Erekin-Taner, Nilufer, Fagan, Anne, Farlow, Marty, Farrar, Angela, Feldman, Howard, Flynn, Gigi, Fox, Nick, Franklin, Erin, Fujii, Hisako, Gant, Cortaiga, Gardener, Samantha, Ghetti, Bernardino, Goate, Alison, Goldman, Jill, Gordon, Brian, Graff-Radford, Neill, Gray, Julia, Gurney, Jenny, Hassenstab, Jason, Hirohara, Mie, Holtzman, David, Hornbeck, Russ, DiBari, Siri Houeland, Ikeuchi, Takeshi, Ikonomovic, Snezana, Jerome, Gina, Jucker, Mathias, Karch, Celeste, Kasuga, Kensaku, Kawarabayashi, Takeshi, Klunk, William (Bill), Koeppe, Robert, Kuder-Buletta, Elke, Laske, Christoph, Lee, Jae-Hong, Levin, Johannes, Marcus, Daniel, Martins, Ralph, Mason, Neal Scott, Masters, Colin, Maue-Dreyfus, Denise, McDade, Eric, Montoya, Lucy, Mori, Hiroshi, Morris, John, Nagamatsu, Akem, Neimeyer, Katie, Noble, James, Norton, Joanne, Perrin, Richard, Raichle, Marc, Ringman, John, Roh, Jee Hoon, Salloway, Stephen, Schofield, Peter, Shimada, Hiroyuki, Shiroto, Tomoyo, Shoji, Mikio, Sigurdson, Wendy, Sohrabi, Hamid, Sparks, Paige, Suzuki, Kazushi, Swisher, Laura, Taddei, Kevin, Wang, Jen, Wang, Peter, Weiner, Mike, Wolfsberger, Mary, Xiong, Chengjie, Xu, Xiong, Tam, Angela, Labonté, Anne, Pichet Binette, Alexa, Faubert, Anne-Marie, Mathieu, Axel, Madjar, Cécile, Carrier, Charles Edouard, Dansereau, Christian, Kazazian, Christina, Lepage, Claude, Picard, Cynthia, Maillet, David, Michaud, Diane, Couture, Doris, Dea, Doris, Cuello, Claudio, Barkun, Alan, Evans, Alan, Courcot, Blandine, Tardif, Christine, Debacker, Clément, Jack, Clifford R., Fontaine, David, Knopman, David S., Maultaup, Gerhard, Near, Jamie, Leoutsakos, Jeannie-Marie, Maltais, Jean-Robert, Brandt, Jason, Pruessner, Jens, Morris, John C., Breitner, John C.S., Poirier, Judes, Cheewakriengkrai, Laksanun, Münter, Lisa-Marie, Collins, Louis, Chakravarty, Mallar, Sager, Mark A., Dauar-Tedeschi, Marina, Eisenberg, Mark, Rajah, Natasha, Aisen, Paul, Toussaint, Joanne, Rosa-Neto, Pedro, Bellec, Pierre, Kostopoulos, Penelope, Etienne, Pierre, Tariot, Pierre N., Orban, Pierre, Sperling, Reisa A., Hoge, Rick, Thomas, Ronald G., Gauthier, Serge, Craft, Suzanne, Villeneuve, Sylvia, Montine, Thomas J., Nair, Vasavan, Bohbot, Véronique, Venugopalan, Vinod, Fonov, Vladimir, Ituria-Medina, Yasser, Khachaturian, Zaven S., Teigner, Eduard, Anthal, Elena, Yu, Elsa, Ferdinand, Fabiola, Pogossova, Galina, Mayrand, Ginette, Duclair, Guerda, Gagné, Guylaine, Newbold-Fox, Holly, Leppert, Illana, Vallée, Isabelle, Vogel, Jacob W., Tremblay-Mercier, Jennifer, Frenette, Joanne, Frappier, Josée, Kat, Justin, Miron, Justin, Wan, Karen, Mahar, Laura, Carmo, Leopoldina, Théroux, Louise, Dadar, Mahsa, Dufour, Marianne, Lafaille-Magnan, Marie-Elyse, Appleby, Melissa, Savard, Mélissa, Tuwaig, Miranda, Petkova, Mirela, Rioux, Pierre, Meyer, Pierre-François, El-Khoury, Rana, Gordon, Renee, Giles, Renuka, Das, Samir, Wang, Seqian, Tabrizi, Shirin, Mathotaarachchi, Sulantha, Dubuc, Sylvie, Lee, Tanya, Beaudry, Thomas, Gervais, Valérie, Pagé, Véronique, Gonneaud, Julie, Ayranci, Gülebru, Pascoal, Tharick A., Desautels, René, Benbouhoud, Fatiha, Saint-Fort, Eunice Farah, Verfaillie, Sander C.J., Farzin, Sarah, Salaciak, Alyssa, Tullo, Stephanie, Vachon-Presseau, Etienne, Daoust, Leslie-Ann, Köbe, Theresa, Spreng, Nathan, McSweeney, Melissa, Nilsson, Nathalie, Pishnamazi, Morteza, Bedetti, Christophe, Vachon-Presseau, Étienne, Bateman, Randall, and Collins, D. Louis

Published
2021
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6. Subjective cognitive decline and rates of incident Alzheimer's disease and non–Alzheimer's disease dementia

Author

Boada, Mercè, de Deyn, Peter Paul, Jones, Roy, Frisoni, Giovanni, Spiru, Luiza, Nobili, Flavio, Freund-Levi, Yvonne, Soininen, Hilkka, Verhey, Frans, Wallin, Åsa K., Touchon, Jacques, Rikkert, Marcel Olde, Rigaud, Anne-Sophie, Bullock, Roger, Tsolaki, Magda, Vellas, Bruno, Wilcock, Gordon, Hampel, Harald, Froelich, Lutz, Bakardjian, Hovagim, Benali, Habib, Bertin, Hugo, Bonheur, Joel, Boukadida, Laurie, Boukerrou, Nadia, Cavedo, Enrica, Chiesa, Patrizia, Colliot, Olivier, Dubois, Bruno, Dubois, Marion, Epelbaum, Stéphane, Gagliardi, Geoffroy, Genthon, Remy, Habert, Marie-Odile, Houot, Marion, Kas, Aurélie, Lamari, Foudil, Levy, Marcel, Lista, Simone, Metzinger, Christiane, Mochel, Fanny, Nyasse, Francis, Poisson, Catherine, Potier, Marie-Claude, Revillon, Marie, Santos, Antonio, Andrade, Katia Santos, Sole, Marine, Surtee, Mohmed, Thiebaud de Schotten, Michel, Vergallo, Andrea, Younsi, Nadjia, Slot, Rosalinde E.R., Sikkes, Sietske A.M., Berkhof, Johannes, Brodaty, Henry, Buckley, Rachel, Dardiotis, Efthimios, Guillo-Benarous, Francoise, Kochan, Nicole A., Luck, Tobias, Maruff, Paul, Molinuevo, José Luis, Kornhuber, Johannes, Reisberg, Barry, Riedel-Heller, Steffi G., Risacher, Shannon L., Roehr, Susanne, Sachdev, Perminder S., Scarmeas, Nikolaos, Scheltens, Philip, Shulman, Melanie B., Saykin, Andrew J., Verfaillie, Sander C.J., Visser, Pieter Jelle, Vos, Stephanie J.B., Wagner, Michael, Wolfsgruber, Steffen, Jessen, Frank, and van der Flier, Wiesje M.

Published
2019
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7. Smaller medial temporal lobe volumes in individuals with subjective cognitive decline and biomarker evidence of Alzheimer's disease—Data from three memory clinic studies

Author

Hu, Xiaochen, Teunissen, Charlotte E., Spottke, Annika, Heneka, Michael T., Düzel, Emrah, Peters, Oliver, Li, Siyao, Priller, Josef, Buerger, Katharina, Teipel, Stefan, Laske, Christoph, Verfaillie, Sander C.J., Barkhof, Frederik, Coll-Padrós, Nina, Rami, Lorena, Molinuevo, Jose Luis, van der Flier, Wiesje M., and Jessen, Frank

Published
2019
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8. Neuropsychological functioning after COVID-19: minor differences between individuals with and without persistent complaints after SARS-CoV-2 infection.

Author

Verveen, Anouk, Verfaillie, Sander C.J, Visser, Denise, Koch, Dook W., Verwijk, Esmée, Geurtsen, Gert J., Roor, Jeroen, Appelman, Brent, Boellaard, Ronald, van Heugten, Caroline M., Horn, Janneke, Hulst, Hanneke E., de Jong, Menno D., Kuut, Tanja A., van der Maaden, Tessa, van Os, Yvonne M.G, Prins, Maria, Visser-Meily, Johanna M.A, van Vugt, Michele, and van den Wijngaard, Cees C.

Subjects
*EXECUTIVE function, *COGNITIVE processing speed, *SARS-CoV-2, *FATIGUE (Physiology), *COVID-19, *TRAIL Making Test
Abstract

AbstractObjective: It is unclear how self-reported severe fatigue and difficulty concentrating after SARS-CoV-2 infection relate to objective neuropsychological functioning. The study aimed to compare neuropsychological functioning between individuals with and without these persistent subjective complaints. Method: Individuals with and without persistent severe fatigue (Checklist Individual Strength (CIS) fatigue ≥ 35) and difficulty concentrating (CIS concentration ≥ 18) at least 3 months after SARS-CoV-2 infection were included. Neuropsychological assessment was performed on overall cognitive functioning, attention, processing speed, executive functioning, memory, visuo-construction, and language (18 tests). T-scores −1.5 SD below population normative data (T ≤ 35) were classified as “impaired”. Results: 230 participants were included in the study, of whom 22 were excluded from the analysis due to invalid performance. Of the participants included in the analysis, 111 reported persistent complaints of severe fatigue and difficulty concentrating and 97 did not. Median age was 54 years, 59% (n = 126) were female, and participants were assessed a median of 23 months after first infection (IQR: 16–28). With bivariate logistic regression, individuals with persistent complaints had an increased likelihood of slower information processing speed performance on the Stroop word reading (OR = 2.45, 95%CI = 1.02–5.84) compared to those without persistent complaints. Demographic or clinical covariates (e.g. hospitalization) did not influence this association. With linear regression techniques, persistent complaints were associated with lower t-scores on the D2 CP, TMT B, and TMT B|A. There were no differences in performance on the other neuropsychological tests. Conclusions: Individuals with subjective severe fatigue and difficulty concentrating after COVID-19 do not typically demonstrate cognitive impairment on extensive neuropsychological testing. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Longitudinal tau binding in tau‐PET negative patients with clinical Alzheimer’s disease

Author

Rikken, Roos M., primary, Coomans, Emma M., additional, de Koning, Lotte A., additional, Visser, Denise, additional, Verfaillie, Sander C.J., additional, den Braber, Anouk, additional, Collij, Lyduine E., additional, Golla, Sandeep S.V., additional, Barkhof, Frederik, additional, Visser, Pieter Jelle, additional, Scheltens, Philip, additional, van der Flier, Wiesje M., additional, Boellaard, Ronald, additional, Ossenkoppele, Rik, additional, van Berckel, Bart N.M., additional, Vijverberg, Everard G.B., additional, and van de Giessen, Elsmarieke, additional

Published
2023
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10. The association between AD biomarkers and neuropsychiatric symptoms in subjective cognitive decline; the SCIENCe project

Author

Trieu, Calvin, primary, van Harten, Argonde C., additional, van Leeuwenstijn, Mardou S. S. A., additional, Kroeze, Lior A., additional, Ebenau, Jarith L., additional, Verberk, Inge M.W., additional, Sikkes, Sietske A.M., additional, Verfaillie, Sander C.J., additional, Giessen, Elsmarieke, additional, Teunissen, Charlotte E., additional, and van der Flier, Wiesje M., additional

Published
2023
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11. Performance of a [18F]Flortaucipir PET Visual Read Method Across the Alzheimer Disease Continuum and in Dementia With Lewy Bodies

Author

Coomans, Emma M., primary, de Koning, Lotte A., additional, Rikken, Roos M., additional, Verfaillie, Sander C.J., additional, Visser, Denise, additional, den Braber, Anouk, additional, Tomassen, Jori, additional, van de Beek, Marleen, additional, Collij, Lyduine E., additional, Lemstra, Afina W., additional, Windhorst, Albert D., additional, Barkhof, Frederik, additional, Golla, Sandeep S.V., additional, Visser, Pieter Jelle, additional, Scheltens, Philip, additional, van der Flier, Wiesje M., additional, Ossenkoppele, Rik, additional, van Berckel, Bart N.M., additional, and van de Giessen, Elsmarieke, additional

Published
2023
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12. Subjective Cognitive Decline Is Associated With Altered Default Mode Network Connectivity in Individuals With a Family History of Alzheimer’s Disease

Author

Aisen, Paul, Anthal, Elena, Appleby, Melissa, Ayranci, Gülebru, Barkun, Alan, Beaudry, Thomas, Bellec, Pierre, Benbouhoud, Fatiha, Bohbot, Veronique, Brandt, Jason, Breitner, John, Carmo, Leopoldina, Carrier Charles, Edouard, Chakravarty, Mallar, Cheewakriengkrai, Laksanun, Collins, Louis, Courcot, Blandine, Couture, Doris, Craft, Suzanne, Cuello, Claudio, Dadar, Mahsa, Dansereau, Christian, DasSamir, Marina, Dauar-Tedeschi, Dea, Doris, Debacker, Clement, Desautels, Rene, Dubuc, Sylvie, Duclair, Guerda, Dufour, Marianne, Eisenberg, Mark, El-Khoury, Rana, Etienne, Pierre, Evans, Alan, Faubert, Anne-Marie, Ferdinand, Fabiola, Fonov, Vladimir, Fontaine, David, Frappier, Josée, Joanne, Frenette, Gagne, Guylaine, Gauthier, Serge, Gervais, Valérie, Giles, Renuka, Gonneaud, Julie, Gordon, Renee, Hoge, Rick, Hyman, Bradley, Ituria-Medina, Yasser, Jack, Clifford, Kat, Justin, Kazazian, Christina, Khachaturian, Zaven, Knopman, David, Kostopoulos, Penelope, Labonte, Anne, Lafaille-Magnan, Marie-Elyse, Lee, Tanya, Leoutsakos, Jeannie-Marie, Lepage, Claude, Leppert, Illana, Madjar, Cécile, Mahar, Laura, Maillet, David, Maltais, Jean-Robert, Mathieu, Axel, Mathotaarachchi, Sulantha, Maultaup, Gerhard, Mayrand, Ginette, Meyer, Pierre-François, Michaud, Diane, Miron, Justin, Montine, Thomas, Morris, John, Münter, Lisa-Marie, Nair, Vasavan, Near, Jamie, Newbold-Fox, Holly, Orban, Pierre, Page, Véronique, Pascoal, Tharick, Petkova, Mirela, Picard, Cynthia, Pichet Binette, Alexa, Pogossova, Galina, Poirier, Judes, Pruessner, Jens, Rajah, Natasha, Rioux, Pierre, Rosa-Neto, Pedro, Sager, Mark, Saint-Fort, Eunice Farah, Savard, Mélissa, Sperling, Reisa, Tabrizi, Shirin, Tam, Angela, Tardif, Christine, Tariot, Pierre, Teigner, Eduard, Theroux, Louise, Thomas, Ronald, Toussaint, Paule-Joanne, Tremblay-Mercier, Jennifer, Tuwaig, Miranda, Vallee, Isabelle, Venugopalan, Vinod, Verfaillie, Sander, Villeneuve, Sylvia, Vogel, Jacob, Wan, Karen, Wang, Seqian, Yu, Elsa, Verfaillie, Sander C.J., Vachon-Presseau, Etienne, Ossenkoppele, Rik, Scheltens, Philip, van der Flier, Wiesje M., and Breitner, John C.S.

Published
2018
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13. Computer-assisted prediction of clinical progression in the earliest stages of AD

Author

Rhodius-Meester, Hanneke F.M., Liedes, Hilkka, Koikkalainen, Juha, Wolfsgruber, Steffen, Coll-Padros, Nina, Kornhuber, Johannes, Peters, Oliver, Jessen, Frank, Kleineidam, Luca, Molinuevo, José Luis, Rami, Lorena, Teunissen, Charlotte E., Barkhof, Frederik, Sikkes, Sietske A.M., Wesselman, Linda M.P., Slot, Rosalinde E.R., Verfaillie, Sander C.J., Scheltens, Philip, Tijms, Betty M., Lötjönen, Jyrki, and van der Flier, Wiesje M.

Published
2018
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16. ATN classification and clinical progression in subjective cognitive decline: The SCIENCe project

Author

Ebenau, Jarith L., Timmers, Tessa, Wesselman, Linda M.P., Verberk, Inge M.W., Verfaillie, Sander C.J., Slot, Rosalinde E.R., van Harten, Argonde C., Teunissen, Charlotte E., Barkhof, Frederik, van den Bosch, Karlijn A., van Leeuwenstijn, Mardou, Tomassen, Jori, Braber, Anouk den, Visser, Pieter Jelle, Prins, Niels D., Sikkes, Sietske A.M., Scheltens, Philip, van Berckel, Bart N.M., and van der Flier, Wiesje M.

Published
2020
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20. A Head-to-Head Comparison Between Plasma pTau181 and Tau PET Along the Alzheimer’s Disease Continuum

Author

Coomans, Emma M., primary, Verberk, Inge M.W., additional, Ossenkoppele, Rik, additional, Verfaillie, Sander C.J., additional, Visser, Denise, additional, Gouda, Mariam, additional, Tuncel, Hayel, additional, Wolters, Emma E., additional, Timmers, Tessa, additional, Windhorst, Albert D., additional, Golla, Sandeep S.V., additional, Scheltens, Philip, additional, van, Wiesje M., additional, Flier, der, additional, van Berckel, Bart N.M., additional, and Teunissen, Charlotte E., additional

Published
2022
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22. Predicting cortical thickness with [18F]flortaucipir PET: A longitudinal MRI study.

Author

Visser, Denise, Ossenkoppele, Rik, Bosch, Iris W.M., Brouwer, Iman, Tuncel, Hayel, Coomans, Emma M., Rikken, Roos M., Mastenbroek, Sophie E, Verfaillie, Sander C.J., Golla, Sandeep S.V., Barkhof, Frederik, van der Flier, Wiesje M., and van Berckel, Bart N.M.

Abstract

Background: The association between tau pathology and neurodegeneration (atrophy) in Alzheimer's disease (AD) is not fully understood. This study aimed to investigate whether tau pathology is associated with concurrent and longitudinal cortical thickness in individuals along the AD continuum. Method: We included 92 amyloid‐positive cognitively impaired individuals (age 65±7, 48% female, MMSE 23±4) with AD dementia (n = 73) or mild cognitive impairment due to AD (MCI, n = 19) and 61 cognitively normal individuals (CN; age 66±8, 48% female, MMSE 29±1) with subjective cognitive decline (SCD, n = 55, 19 amyloid‐positive) or healthy controls (HC, n = 6, amyloid‐status unknown). All participants underwent dynamic [18F]flortaucipir PET and structural 3T‐MRI at baseline. A subset underwent two‐year follow‐up structural 3T‐MRI (CN: n = 35, time‐interval 24±8 months; AD: n = 26; time‐interval 28±4 months). Parametric [18F]flortaucipir binding potential (BPND) images were generated using receptor parametric mapping (cerebellar gray matter reference region) to quantify tau pathology. Cortical thickness (over time) was measured using Freesurfer (version 6.0.1). Regional associations between [18F]flortaucipir BPND and cortical thickness were assessed using linear mixed models in three commonly used a priori defined regions‐of‐interest, including entorhinal, middle‐and inferior temporal, and neocortical areas. Models were adjusted for age, sex and amyloid status (in case of CN individuals). Result: For cognitively impaired individuals, higher [18F]flortaucipir BPND (in all three regions) was associated with lower concurrent cortical thickness in the entorhinal cortex [Table‐1&Fig‐1]. Higher middle‐ and inferior temporal and neocortical BPND was associated with cortical thinning over time within the same region (intra‐regionally). Higher middle‐ and inferior temporal BPND additionally showed associations with cortical thinning over time in the neocortex (inter‐regionally). For cognitively normal individuals, we found no associations between [18F]flortaucipir BPND and cortical thickness (over time) [Table‐1&Figure‐1]. Conclusion: Tau pathology is associated with both concurrent and longitudinal atrophy in a region‐specific manner in cognitively impaired individuals (MCI/AD), but not in cognitively normal individuals (HC/SCD). The regional‐specificity of these associations might suggest that there are similarities between tau‐related progression patterns and patterns of neurodegeneration. Taking into account a temporal delay between the development of region‐specific tau pathology and neurodegeneration, this potentially suggests that tau pathology is a (partial) driver of neurodegeneration in AD. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Long COVID is associated with extensive in-vivo neuroinflammation on [18F]DPA-714 PET

Author

Visser, Denise, primary, Golla, Sandeep S.V., additional, Verfaillie, Sander C.J., additional, Coomans, Emma M., additional, Rikken, Roos M., additional, van de Giessen, Elsmarieke M., additional, den Hollander, Marijke E., additional, Verveen, Anouk, additional, Yaqub, Maqsood, additional, Barkhof, Frederik, additional, Horn, Janneke, additional, Koopman, Bart, additional, Schober, Patrick, additional, Koch, Dook W., additional, Schuit, Robert C., additional, Windhorst, Albert D., additional, Kassiou, Michael, additional, Boellaard, Ronald, additional, van Vugt, Michele, additional, Knoop, Hans, additional, Tolboom, Nelleke, additional, and van Berckel, Bart N.M., additional

Published
2022
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25. [ 18 F]Flortaucipir PET Across Various MAPT Mutations in Presymptomatic and Symptomatic Carriers

Author

Wolters, Emma E., primary, Papma, Janne M., additional, Verfaillie, Sander C.J., additional, Visser, Denise, additional, Weltings, Emma, additional, Groot, Colin, additional, van der Ende, Emma L., additional, Giannini, Lucia A.A., additional, Tuncel, Hayel, additional, Timmers, Tessa, additional, Boellaard, Ronald, additional, Yaqub, Maqsood, additional, van Assema, Danielle M.E., additional, Kuijper, Dennis A., additional, Segbers, Marcel, additional, Rozemuller, Annemieke J.M., additional, Barkhof, Frederik, additional, Windhorst, Albert D., additional, van der Flier, Wiesje M., additional, Pijnenburg, Yolande A.L., additional, Scheltens, Philip, additional, van Berckel, Bart N.M., additional, van Swieten, John C., additional, Ossenkoppele, Rik, additional, and Seelaar, Harro, additional

Published
2021
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26. Correction to: Regional [18F]flortaucipir PET is more closely associated with disease severity than CSF p-tau in Alzheimer’s disease (European Journal of Nuclear Medicine and Molecular Imaging, (2020), 47, 12, (2866-2878), 10.1007/s00259-020-04758-2)

Author

Wolters, Emma E., Ossenkoppele, Rik, Verfaillie, Sander C.J., Coomans, Emma M., Timmers, Tessa, Visser, Denise, Tuncel, Hayel, Golla, Sandeep S.V., Windhorst, Albert D., Boellaard, Ronald, van der Flier, Wiesje M., Teunissen, Charlotte E., Scheltens, Philip, van Berckel, Bart N.M., Radiology and nuclear medicine, Amsterdam Neuroscience - Neurodegeneration, Neurology, Clinical chemistry, Amsterdam Reproduction & Development (AR&D), APH - Personalized Medicine, and APH - Methodology

Abstract

The authors regret to inform readers that the following error was detected in the original article. The values for entorhinal, limbic and neortical SUVr were switched between SCD Aβ + and Aβ- in Table 1 and have now been corrected. Unnecessary symbols in Table 2 have been removed.

Published
2020

27. Correction to:Regional [18F]flortaucipir PET is more closely associated with disease severity than CSF p-tau in Alzheimer’s disease (European Journal of Nuclear Medicine and Molecular Imaging, (2020), 47, 12, (2866-2878), 10.1007/s00259-020-04758-2)

Author

Wolters, Emma E., Ossenkoppele, Rik, Verfaillie, Sander C.J., Coomans, Emma M., Timmers, Tessa, Visser, Denise, Tuncel, Hayel, Golla, Sandeep S.V., Windhorst, Albert D., Boellaard, Ronald, van der Flier, Wiesje M., Teunissen, Charlotte E., Scheltens, Philip, and van Berckel, Bart N.M.

Abstract

The authors regret to inform readers that the following error was detected in the original article. The values for entorhinal, limbic and neortical SUVr were switched between SCD Aβ + and Aβ- in Table 1 and have now been corrected. Unnecessary symbols in Table 2 have been removed.

Published
2020
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28. 18F]Flortaucipir PET Across Various MAPT Mutations in Presymptomatic and Symptomatic Carriers

Author

Wolters, Emma E., Papma, Janne M., Verfaillie, Sander C.J., Visser, Denise, Weltings, Emma, Groot, Colin, van der Ende, Emma L., Giannini, Lucia A.A., Tuncel, Hayel, Timmers, Tessa, Boellaard, Ronald, Yaqub, Maqsood, van Assema, Danielle M.E., Kuijper, Dennis A., Segbers, Marcel, Rozemuller, Annemieke J.M., Barkhof, Frederik, Windhorst, Albert D., van der Flier, Wiesje M., Pijnenburg, Yolande A.L., Scheltens, Philip, van Berckel, Bart N.M., van Swieten, John C., Ossenkoppele, Rik, Seelaar, Harro, Wolters, Emma E., Papma, Janne M., Verfaillie, Sander C.J., Visser, Denise, Weltings, Emma, Groot, Colin, van der Ende, Emma L., Giannini, Lucia A.A., Tuncel, Hayel, Timmers, Tessa, Boellaard, Ronald, Yaqub, Maqsood, van Assema, Danielle M.E., Kuijper, Dennis A., Segbers, Marcel, Rozemuller, Annemieke J.M., Barkhof, Frederik, Windhorst, Albert D., van der Flier, Wiesje M., Pijnenburg, Yolande A.L., Scheltens, Philip, van Berckel, Bart N.M., van Swieten, John C., Ossenkoppele, Rik, and Seelaar, Harro

Abstract

OBJECTIVE: To assess the [18F]flortaucipir binding distribution across MAPT mutations in presymptomatic and symptomatic carriers. METHODS: We compared regional [18F]flortaucipir binding potential (BPND) derived from a 130-minute dynamic [18F]flortaucipir PET scan in 9 (pre)symptomatic MAPT mutation carriers (4 with P301L [1 symptomatic], 2 with R406W [1 symptomatic], 1 presymptomatic L315R, 1 presymptomatic S320F, and 1 symptomatic G272V carrier) with 30 cognitively normal controls and 52 patients with Alzheimer disease. RESULTS: [18F]Flortaucipir BPND images showed overall highest binding in the symptomatic carriers. This was most pronounced in the symptomatic R406W carrier in whom tau binding exceeded the normal control range in the anterior cingulate cortex, insula, amygdala, temporal, parietal, and frontal lobe. Elevated medial temporal lobe BPND was observed in a presymptomatic R406W carrier. The single symptomatic carrier and 1 of the 3 presymptomatic P301L carriers showed elevated [18F]flortaucipir BPND in the insula, parietal, and frontal lobe compared to controls. The symptomatic G272V carrier exhibited a widespread elevated cortical BPND, with at neuropathologic examination a combination of 3R pathology and encephalitis. The L315R presymptomatic mutation carrier showed higher frontal BPND compared to controls. The BPND values of the S320F presymptomatic mutation carrier fell within the range of controls. CONCLUSION: Presymptomatic MAPT mutation carriers already showed subtle elevated tau binding, whereas symptomatic MAPT mutation carriers showed a more marked increase in [18F]flortaucipir BPND. Tau deposition was most pronounced in R406W MAPT (pre)symptomatic mutation carriers, which is associated with both 3R and 4R tau accumulation. Thus, [18F]flortaucipir may serve as an early biomarker for MAPT mutation carriers in mutations that cause 3R/4R tauopathies.

Published
2021

29. Amyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal Dominant Alzheimer’s Disease

Author

Pichet Binette, Alexa, primary, Vachon-Presseau, Étienne, additional, Morris, John, additional, Bateman, Randall, additional, Benzinger, Tammie, additional, Collins, D. Louis, additional, Poirier, Judes, additional, Breitner, John C.S., additional, Villeneuve, Sylvia, additional, Allegri, Ricardo, additional, Amtashar, Fatima, additional, Bateman, Randy, additional, Berman, Sarah, additional, Bodge, Courtney, additional, Brandon, Susan, additional, Brooks, William (Bill), additional, Buck, Jill, additional, Buckles, Virginia, additional, Chea, Sochenda, additional, Chhatwal, Jasmeer, additional, Chrem, Patricio, additional, Chui, Helena, additional, Cinco, Jake, additional, Clifford, Jack, additional, Cruchaga, Carlos, additional, D‘Mello, Mirelle, additional, Donahue, Tamara, additional, Douglas, Jane, additional, Edigo, Noelia, additional, Erekin-Taner, Nilufer, additional, Fagan, Anne, additional, Farlow, Marty, additional, Farrar, Angela, additional, Feldman, Howard, additional, Flynn, Gigi, additional, Fox, Nick, additional, Franklin, Erin, additional, Fujii, Hisako, additional, Gant, Cortaiga, additional, Gardener, Samantha, additional, Ghetti, Bernardino, additional, Goate, Alison, additional, Goldman, Jill, additional, Gordon, Brian, additional, Graff-Radford, Neill, additional, Gray, Julia, additional, Gurney, Jenny, additional, Hassenstab, Jason, additional, Hirohara, Mie, additional, Holtzman, David, additional, Hornbeck, Russ, additional, DiBari, Siri Houeland, additional, Ikeuchi, Takeshi, additional, Ikonomovic, Snezana, additional, Jerome, Gina, additional, Jucker, Mathias, additional, Karch, Celeste, additional, Kasuga, Kensaku, additional, Kawarabayashi, Takeshi, additional, Klunk, William (Bill), additional, Koeppe, Robert, additional, Kuder-Buletta, Elke, additional, Laske, Christoph, additional, Lee, Jae-Hong, additional, Levin, Johannes, additional, Marcus, Daniel, additional, Martins, Ralph, additional, Mason, Neal Scott, additional, Masters, Colin, additional, Maue-Dreyfus, Denise, additional, McDade, Eric, additional, Montoya, Lucy, additional, Mori, Hiroshi, additional, Nagamatsu, Akem, additional, Neimeyer, Katie, additional, Noble, James, additional, Norton, Joanne, additional, Perrin, Richard, additional, Raichle, Marc, additional, Ringman, John, additional, Roh, Jee Hoon, additional, Salloway, Stephen, additional, Schofield, Peter, additional, Shimada, Hiroyuki, additional, Shiroto, Tomoyo, additional, Shoji, Mikio, additional, Sigurdson, Wendy, additional, Sohrabi, Hamid, additional, Sparks, Paige, additional, Suzuki, Kazushi, additional, Swisher, Laura, additional, Taddei, Kevin, additional, Wang, Jen, additional, Wang, Peter, additional, Weiner, Mike, additional, Wolfsberger, Mary, additional, Xiong, Chengjie, additional, Xu, Xiong, additional, Tam, Angela, additional, Labonté, Anne, additional, Pichet Binette, Alexa, additional, Faubert, Anne-Marie, additional, Mathieu, Axel, additional, Madjar, Cécile, additional, Carrier, Charles Edouard, additional, Dansereau, Christian, additional, Kazazian, Christina, additional, Lepage, Claude, additional, Picard, Cynthia, additional, Maillet, David, additional, Michaud, Diane, additional, Couture, Doris, additional, Dea, Doris, additional, Cuello, Claudio, additional, Barkun, Alan, additional, Evans, Alan, additional, Courcot, Blandine, additional, Tardif, Christine, additional, Debacker, Clément, additional, Jack, Clifford R., additional, Fontaine, David, additional, Knopman, David S., additional, Maultaup, Gerhard, additional, Near, Jamie, additional, Leoutsakos, Jeannie-Marie, additional, Maltais, Jean-Robert, additional, Brandt, Jason, additional, Pruessner, Jens, additional, Morris, John C., additional, Cheewakriengkrai, Laksanun, additional, Münter, Lisa-Marie, additional, Collins, Louis, additional, Chakravarty, Mallar, additional, Sager, Mark A., additional, Dauar-Tedeschi, Marina, additional, Eisenberg, Mark, additional, Rajah, Natasha, additional, Aisen, Paul, additional, Toussaint, Joanne, additional, Rosa-Neto, Pedro, additional, Bellec, Pierre, additional, Kostopoulos, Penelope, additional, Etienne, Pierre, additional, Tariot, Pierre N., additional, Orban, Pierre, additional, Sperling, Reisa A., additional, Hoge, Rick, additional, Thomas, Ronald G., additional, Gauthier, Serge, additional, Craft, Suzanne, additional, Montine, Thomas J., additional, Nair, Vasavan, additional, Bohbot, Véronique, additional, Venugopalan, Vinod, additional, Fonov, Vladimir, additional, Ituria-Medina, Yasser, additional, Khachaturian, Zaven S., additional, Teigner, Eduard, additional, Anthal, Elena, additional, Yu, Elsa, additional, Ferdinand, Fabiola, additional, Pogossova, Galina, additional, Mayrand, Ginette, additional, Duclair, Guerda, additional, Gagné, Guylaine, additional, Newbold-Fox, Holly, additional, Leppert, Illana, additional, Vallée, Isabelle, additional, Vogel, Jacob W., additional, Tremblay-Mercier, Jennifer, additional, Frenette, Joanne, additional, Frappier, Josée, additional, Kat, Justin, additional, Miron, Justin, additional, Wan, Karen, additional, Mahar, Laura, additional, Carmo, Leopoldina, additional, Théroux, Louise, additional, Dadar, Mahsa, additional, Dufour, Marianne, additional, Lafaille-Magnan, Marie-Elyse, additional, Appleby, Melissa, additional, Savard, Mélissa, additional, Tuwaig, Miranda, additional, Petkova, Mirela, additional, Rioux, Pierre, additional, Meyer, Pierre-François, additional, El-Khoury, Rana, additional, Gordon, Renee, additional, Giles, Renuka, additional, Das, Samir, additional, Wang, Seqian, additional, Tabrizi, Shirin, additional, Mathotaarachchi, Sulantha, additional, Dubuc, Sylvie, additional, Lee, Tanya, additional, Beaudry, Thomas, additional, Gervais, Valérie, additional, Pagé, Véronique, additional, Gonneaud, Julie, additional, Ayranci, Gülebru, additional, Pascoal, Tharick A., additional, Desautels, René, additional, Benbouhoud, Fatiha, additional, Saint-Fort, Eunice Farah, additional, Verfaillie, Sander C.J., additional, Farzin, Sarah, additional, Salaciak, Alyssa, additional, Tullo, Stephanie, additional, Vachon-Presseau, Etienne, additional, Daoust, Leslie-Ann, additional, Köbe, Theresa, additional, Spreng, Nathan, additional, McSweeney, Melissa, additional, Nilsson, Nathalie, additional, Pishnamazi, Morteza, additional, and Bedetti, Christophe, additional

Published
2021
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30. Regional tau pathology is associated with loss of synapses and reduced synaptic activity: A combined [18F]flortaucipir, [11C]UCB‐J and magnetoencephalography study

Author

Coomans, Emma M., primary, Schoonhoven, Deborah N., additional, Tuncel, Hayel, additional, Verfaillie, Sander C.J., additional, Wolters, Emma E., additional, Boellaard, Ronald, additional, Ossenkoppele, Rik, additional, Scheper, Wiep, additional, Schober, Patrick, additional, Sweeney, Steven P., additional, Ryan, J. Michael, additional, Schuit, Robert C., additional, Windhorst, Albert D., additional, Barkhof, Frederik, additional, Scheltens, Philip, additional, Golla, Sandeep S.V., additional, Arjan, Hillebrand, additional, Gouw, Alida A., additional, and Van Berckel, Bart N.M., additional

Published
2020
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31. Early‐onset Alzheimer’s disease is related to differential spatial patterns of tau pathology and cognitive impairment

Author

Verfaillie, Sander C.J., primary, Visser, Denise, additional, Wolters, Emma E., additional, Coomans, Emma M., additional, Timmers, Tessa, additional, Tuncel, Hayel, additional, Boellaard, Ronald, additional, Golla, Sandeep S.V., additional, Windhorst, Albert D., additional, Scheltens, Philip, additional, van Der Flier, Wiesje, additional, Ossenkoppele, Rik, additional, and Van Berckel, Bart N.M., additional

Published
2020
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32. Tau pathology, relative cerebral flow and cognition in dementia with Lewy bodies

Author

Wolters, Emma E., primary, van de Beek, Marleen, additional, Ossenkoppele, Rik, additional, Verfaillie, Sander C.J., additional, Coomans, Emma M., additional, Timmers, Tessa, additional, Visser, Denise, additional, Tuncel, Hayel, additional, Golla, Sandeep S.V., additional, Windhorst, Albert D., additional, Scheltens, Philip, additional, van Der Flier, Wiesje, additional, Lemstra, Afina W., additional, and Van Berckel, Bart N.M., additional

Published
2020
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33. Grey zone amyloid burden heralds future memory decline: The SCIENCe Project

Author

Ebenau, Jarith L., primary, Verfaillie, Sander C.J., additional, van den Bosch, Karlijn A., additional, Timmers, Tessa, additional, Wesselman, Linda M.P., additional, van Leeuwenstijn, Mardou, additional, Barkhof, Frederik, additional, Prins, Niels D., additional, Scheltens, Philip, additional, van Der Flier, Wiesje, additional, and Van Berckel, Bart N.M., additional

Published
2020
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34. PARAMETRIC IMAGING OF [18F]FLORBETAPIR: A TEST-RETEST STUDY IN HEALTHY SUBJECTS AND PATIENTS WITH ALZHEIMER’S DISEASE

Author

Verfaillie, Sander C.J., Golla, Sandeep S.V., van der Weijden, Chris W.J., Timmers, Tessa, Schober, Patrick, Schuit, Robert C., Windhorst, Albert D., Scheltens, Philip, Van der Flier, Wiesje M., Lammertsma, Adriaan A., van Berckel, Bart N.M., Boellaard, Ronald, Radiology and nuclear medicine, Neurology, Amsterdam Neuroscience - Neurodegeneration, Anesthesiology, CCA - Imaging and biomarkers, CCA - Cancer Treatment and quality of life, Amsterdam Neuroscience - Brain Imaging, CCA - Cancer biology and immunology, APH - Personalized Medicine, APH - Methodology, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Quality of Care, ACS - Heart failure & arrhythmias, and ACS - Microcirculation

Published
2018
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35. O5‐01‐03: EARLY TAU PET PATHOLOGY IS ASSOCIATED WITH MEMORY PERFORMANCE IN COGNITIVELY UNIMPAIRED INDIVIDUALS WITH SCD: THE SCIENCE PROJECT

Author

Timmers, Tessa, primary, Ossenkoppele, Rik, additional, Verfaillie, Sander C.J., additional, Wolters, Emma E., additional, Visser, Denise, additional, Scheltens, Philip, additional, Schmidt, Mark E., additional, Boellaard, Ronald, additional, Golla, Sandeep S.V., additional, van der Flier, Wiesje M., additional, and Van Berckel, Bart N.M., additional

Published
2019
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36. F1‐04‐03: ATN BIOMARKER MODEL AS A DETERMINANT OF COGNITIVE DECLINE AND INCIDENT CLINICAL PROGRESSION IN SUBJECTIVE COGNITIVE DECLINE: THE SCIENCE PROJECT

Author

Ebenau, Jarith, primary, Timmers, Tessa, additional, Wesselman, Linda M.P., additional, Verberk, Inge M.W., additional, Verfaillie, Sander C.J., additional, Slot, Rosalinde E.R., additional, Teunissen, Charlotte E., additional, Barkhof, Frederik, additional, van den Bosch, Karlijn, additional, van Leeuwenstijn, Mardou, additional, Prins, Niels D., additional, Sikkes, Sietske A.M., additional, Scheltens, Philip, additional, Van Berckel, Bart N.M., additional, and van der Flier, Wiesje M., additional

Published
2019
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37. P4‐316: LONGITUDINAL DYNAMIC [18F]FLORTAUCIPIR PET REVEALS INCREASED EARLY STAGE TAU PATHOLOGY IN INDIVIDUALS WITH SUBJECTIVE COGNITIVE DECLINE

Author

Visser, Denise, primary, Ossenkoppele, Rik, additional, Verfaillie, Sander C.J., additional, Timmers, Tessa, additional, Wolters, Emma E., additional, Tuncel, Hayel, additional, Coomans, Emma, additional, Schmidt, Mark E., additional, Boellaard, Ronald, additional, Windhorst, Albert D., additional, Scheltens, Philip, additional, van der Flier, Wiesje M., additional, and Van Berckel, Bart N.M., additional

Published
2019
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39. IC‐P‐184: LONGITUDINAL DYNAMIC [18F]FLORTAUCIPIR PET REVEALS INCREASED EARLY STAGE TAU PATHOLOGY IN INDIVIDUALS WITH SUBJECTIVE COGNITIVE DECLINE

Author

Visser, Denise, primary, Ossenkoppele, Rik, additional, Verfaillie, Sander C.J., additional, Timmers, Tessa, additional, Wolters, Emma E., additional, Tuncel, Hayel, additional, Coomans, Emma, additional, Schmidt, Mark E., additional, Boellaard, Ronald, additional, Windhorst, Albert D., additional, Scheltens, Philip, additional, van der Flier, Wiesje M., additional, and Van Berckel, Bart N.M., additional

Published
2019
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40. P2-375: A STUDY TO EVALUATE THE KINETICS AND 28 DAY TEST-RETEST REPEATABILITY AND REPRODUCIBILITY OF THE RADIOLIGAND [11 C]UCB-J FOR BRAIN PET IMAGING IN HEALTHY SUBJECTS AND MILD-MODERATE ALZHEIMER'S DISEASE SUBJECTS

Author

Wolters, Emma E., primary, Tuncel, Hayel, additional, Golla, Sandeep S.V., additional, Verfaillie, Sander C.J., additional, Van Berckel, Bart N.M., additional, Windhorst, Albert D., additional, de Vries, E.F.J., additional, Feltes, Paula K., additional, Glaudemans, A.W.J.M., additional, Sweeney, Steven P., additional, Ryan, J. Michael, additional, Ivarsson, Magnus, additional, Lynch, Berkley A., additional, Scheltens, Philip, additional, De Deyn, Peter Paul, additional, and Boellaard, Ronald, additional

Published
2019
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41. P1-412: [18 F]FLORTAUCIPIR BINDING STRONGLY CORRELATES TO COGNITION ACROSS THE CLINICAL ALZHEIMER'S DISEASE CONTINUUM, INDEPENDENTLY OF CSF TAU

Author

Wolters, Emma E., primary, Ossenkoppele, Rik, additional, Verfaillie, Sander C.J., additional, Coomans, Emma, additional, Timmers, Tessa, additional, Visser, Denise, additional, Tuncel, Hayel, additional, Windhorst, Albert D., additional, Boellaard, Ronald, additional, van der Flier, Wiesje M., additional, Teunissen, Charlotte E., additional, Scheltens, Philip, additional, and Van Berckel, Bart N.M., additional

Published
2019
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42. IC‐P‐187: [18F]FLORTAUCIPIR BINDING STRONGLY CORRELATES TO COGNITION ACROSS THE CLINICAL ALZHEIMER'S DISEASE CONTINUUM, INDEPENDENTLY OF CSF TAU

Author

Wolters, Emma E., primary, Ossenkoppele, Rik, additional, Verfaillie, Sander C.J., additional, Coomans, Emma, additional, Timmers, Tessa, additional, Visser, Denise, additional, Tuncel, Hayel, additional, Windhorst, Albert D., additional, Boellaard, Ronald, additional, van der Flier, Wiesje M., additional, Teunissen, Charlotte E., additional, Scheltens, Philip, additional, and Van Berckel, Bart N.M., additional

Published
2019
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43. Dietary Patterns Are Related to Clinical Characteristics in Memory Clinic Patients with Subjective Cognitive Decline: The SCIENCe Project

Author

Wesselman, Linda M.P., Doorduijn, Astrid S., Leeuw, Francisca A., de, Verfaillie, Sander C.J., Leeuwenstijn-Koopman, Mardou, van, Slot, Rosalinde E.R., Kester, Maartje I., Prins, Niels D., Rest, Ondine, van de, Schueren, Marian A.E., van der, Scheltens, Philip, Sikkes, Sietske A.M., Flier, Wiesje M., van der, Wesselman, Linda M.P., Doorduijn, Astrid S., Leeuw, Francisca A., de, Verfaillie, Sander C.J., Leeuwenstijn-Koopman, Mardou, van, Slot, Rosalinde E.R., Kester, Maartje I., Prins, Niels D., Rest, Ondine, van de, Schueren, Marian A.E., van der, Scheltens, Philip, Sikkes, Sietske A.M., and Flier, Wiesje M., van der

Abstract

As nutrition is one of the modifiable risk factors for cognitive decline, we studied the relationship between dietary quality and clinical characteristics in cognitively normal individuals with subjective cognitive decline (SCD). We included 165 SCD subjects (age: 64 ± 8 years; 45% female) from the SCIENCe project, a prospective memory clinic based cohort study on SCD. The Dutch Healthy Diet Food Frequency Questionnaire (DHD-FFQ) was used to assess adherence to Dutch guidelines on vegetable, fruit, fibers, fish, saturated fat, trans fatty acids, salt and alcohol intake (item score 0-10, higher score indicating better adherence). We measured global cognition (Mini Mental State Examination), cognitive complaints (Cognitive Change Index self-report; CCI) and depressive symptoms (Center for Epidemiologic Studies Depression Scale; CES-D). Using principal component analysis, we identified dietary components and investigated their relation to clinical characteristics using linear regression models adjusted for age, sex and education. We identified three dietary patterns: (i) "low-Fat-low-Salt", (ii) "high-Veggy", and (iii) "low-Alcohol-low-Fish". Individuals with lower adherence on "low-Fat-low-Salt" had more depressive symptoms (β -0.18 (-2.27--0.16)). Higher adherence to "high-Veggy" was associated with higher MMSE scores (β 0.30 (0.21-0.64)). No associations were found with the low-Alcohol-low-Fish component. We showed that in SCD subjects, dietary quality was related to clinically relevant outcomes. These findings could be useful to identify individuals that might benefit most from nutritional prevention strategies to optimize brain health.

Published
2019

45. [18F]Flortaucipir PET Across Various MAPTMutations in Presymptomatic and Symptomatic Carriers

Author

Wolters, Emma E., Papma, Janne M., Verfaillie, Sander C.J., Visser, Denise, Weltings, Emma, Groot, Colin, van der Ende, Emma L., Giannini, Lucia A.A., Tuncel, Hayel, Timmers, Tessa, Boellaard, Ronald, Yaqub, Maqsood, van Assema, Danielle M.E., Kuijper, Dennis A., Segbers, Marcel, Rozemuller, Annemieke J.M., Barkhof, Frederik, Windhorst, Albert D., van der Flier, Wiesje M., Pijnenburg, Yolande A.L., Scheltens, Philip, van Berckel, Bart N.M., van Swieten, John C., Ossenkoppele, Rik, and Seelaar, Harro

Published
2021
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46. Regional distribution of tau pathology in cognitively unimpaired, genetically identical twins: Neuroimaging / Normal brain aging.

Author

Coomans, Emma M., Tomassen, Jori, Wolters, Emma E., Golla, Sandeep S.V., den Hollander, Marijke, Verfaillie, Sander C.J., Collij, Lyduine, Windhorst, Albert D., Boellaard, Ronald, Barkhof, Frederik, Ossenkoppele, Rik, de Geus, Eco J.C., Scheltens, Philip, Visser, Pieter Jelle, Van Berckel, Bart N.M., and den Braber, Anouk

Abstract

Background: Limited information is available on the genetic and environmental contributions to early AD pathology. Within a sample of cognitively unimpaired genetically identical older twins we aimed to assess 1) effects of amyloid‐ß pathology on [18F]flortaucipir (tau) binding and 2) spatial similarities in tau patterns within twin pairs. Method: To date, ten twin pairs (i.e. twenty twins) from the on‐going EMIF‐AD PreclinAD study underwent dynamic (0‐30min and 80‐100min) [18F]flortaucipir PET. Two twin pairs were concordant amyloid‐ß positive, four twin pairs concordant amyloid‐ß negative and four twin pairs amyloid‐ß discordant (i.e. one twin positive and co‐twin negative) based on [18F]flutemetamol visual read. [18F]flortaucipir binding potential (BPND) images were generated using receptor parametric mapping (reference region: cerebellar gray matter). First, we compared [18F]flortaucipir BPND in an early (entorhinal), intermediate (limbic) and late (neocortical) stage tau pathology region between amyloid‐ß positive and negative twins using generalized estimated equation correcting for twin dependency. Next, we examined spatial tau pattern similarities within twin pairs by correlating (Spearman) [18F]flortaucipir BPND across 46 ROIs from the Hammers template between each twin and their co‐twin for each true twin pair. Correlations were also performed for all non‐twin "random" pairs. Correlation coefficients within true twin pairs were compared to the correlation coefficients within random pairs, correcting for age and twin amyloid‐ß status. Results: Amyloid‐ß positive twins showed higher [18F]flortaucipir BPND in entorhinal (p=0.01) and limbic (p=0.04) regions(Table‐1). Fig‐1 shows representative [18F]flortaucipir images of an amyloid‐ß concordant positive, concordant negative and discordant pair, with regional similarities observed in amyloid‐ß concordant pairs as well as dissimilarities in amyloid‐ß discordant pairs (Fig‐1;Fig‐2). Between‐twin correlations across regional [18F]flortaucipir BPND, to assess spatial tau pattern similarities, were higher for true twin pairs (r=0.71±0.17) compared to random pairs (r=0.45±0.23) (p=0.002)(Table‐2). Conclusion: In line with previous studies, amyloid‐ß positive cognitively unimpaired twins showed higher tau deposition in early and intermediate tau stage regions. Furthermore, we observed higher spatial tau pattern similarities within true twin pairs compared to random pairs, suggesting a moderate genetic contribution to mechanisms underlying tau spread. With the upcoming larger sample we aim to further assess genetic and environmental contributions to early AD pathology. [ABSTRACT FROM AUTHOR]

Published
2020
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47. Smaller medial temporal lobe volumes in individuals with subjective cognitive decline and biomarker evidence of Alzheimer's disease—Data from three memory clinic studies

Author

Hu, Xiaochen, primary, Teunissen, Charlotte E., additional, Spottke, Annika, additional, Heneka, Michael T., additional, Düzel, Emrah, additional, Peters, Oliver, additional, Li, Siyao, additional, Priller, Josef, additional, Buerger, Katharina, additional, Teipel, Stefan, additional, Laske, Christoph, additional, Verfaillie, Sander C.J., additional, Barkhof, Frederik, additional, Coll‐Padrós, Nina, additional, Rami, Lorena, additional, Molinuevo, Jose Luis, additional, Flier, Wiesje M., additional, and Jessen, Frank, additional

Published
2018
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49. O2‐06‐03: AMYLOID‐β LOAD IS RELATED TO WORRIES IN INDIVIDUALS WITH SUBJECTIVE COGNITIVE DECLINE

Author

Verfaillie, Sander C.J., primary, Timmers, Tessa, additional, Slot, Rosalinde E.R., additional, van der Weijden, Chris W.J., additional, Wesselman, Linda M.P., additional, Prins, Niels D., additional, Sikkes, Sietske A.M., additional, Lammertsma, Adriaan A., additional, Scheltens, Philip, additional, Ossenkoppele, Rik, additional, van Berckel, Bart N.M., additional, and Van der Flier, Wiesje M., additional

Published
2018
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50. IC‐P‐111: [ 18 F]FLORBETAPIR‐SPECIFIC BINDING IN RELATION TO COGNITION IN SUBJECTIVE COGNITIVE DECLINE

Author

Timmers, Tessa, primary, Ossenkoppele, Rik, additional, Verfaillie, Sander C.J., additional, Wesselman, Linda M.P., additional, Slot, Rosalinde E.R., additional, Prins, Niels D., additional, van der Weijden, Chris W.J., additional, Yaqub, Maqsood M., additional, Lammertsma, Adriaan A., additional, Boellaard, Ronald, additional, Van der Flier, Wiesje M., additional, and van Berckel, Bart N.M., additional

Published
2018
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