1. Lesion patterns in successful and failed thrombolysis in middle cerebral artery stroke
- Author
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Mario Siebler, Riidiger J. Seitz, Hans-Jörg Wittsack, and Verena Sondermann
- Subjects
Male ,medicine.medical_specialty ,Middle Cerebral Artery ,Internal capsule ,medicine.medical_treatment ,Infarction ,Sensitivity and Specificity ,Magnetic resonance angiography ,Lesion ,Fibrinolytic Agents ,Internal medicine ,medicine.artery ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Thrombolytic Therapy ,cardiovascular diseases ,Stroke ,Aged ,medicine.diagnostic_test ,business.industry ,Reproducibility of Results ,Infarction, Middle Cerebral Artery ,Thrombolysis ,Tirofiban ,Middle Aged ,medicine.disease ,Surgery ,Treatment Outcome ,Middle cerebral artery ,Cardiology ,Female ,Neurology (clinical) ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Magnetic Resonance Angiography ,medicine.drug - Abstract
Thrombolysis has been shown to improve neurological recovery in acute stroke. But the response to thrombolysis is variable across patients. We sought to investigate this variability by analyzing the lesion patterns following systemic thrombolysis with recombinant tissue plasminogen activator (rtPA) and tirofiban in middle cerebral artery (MCA) stroke. One hundred three consecutive stroke patients (67 ± 14 years) were grouped according to the site of MCA occlusion and successful or failed recanalization as assessed with magnetic resonance angiography. Infarct lesions were analyzed in T2-weighted magnetic resonance images after 10 days. Patients recovered markedly upon successful recanalization following thrombolysis (p
- Published
- 2009