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10. Response to the letter-to-the-editor “Comments on: Accounting for fractionation and heterogeneous dose distributions in the modelling of osteoradionecrosis in oropharyngeal carcinoma treatment’’

Author

Verduijn, Gerda M., primary, Sijtsema, Nienke D., additional, van Norden, Yvette, additional, Heemsbergen, Wilma D., additional, Mast, Hetty, additional, Sewnaik, Aniel, additional, Chin, Denzel, additional, Baker, Sarah, additional, Capala, Marta E., additional, van der Lugt, Aad, additional, van Meerten, Esther, additional, Hoogeman, Mischa S., additional, and Petit, Steven F., additional

Published
2023
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16. Magnetic Resonance Imaging–Based Delineation of Organs at Risk in the Head and Neck Region

Author

Paczona, Viktor R., primary, Capala, Marta E., additional, Deák-Karancsi, Borbála, additional, Borzási, Emőke, additional, Együd, Zsófia, additional, Végváry, Zoltán, additional, Kelemen, Gyöngyi, additional, Kószó, Renáta, additional, Ruskó, László, additional, Ferenczi, Lehel, additional, Verduijn, Gerda M., additional, Petit, Steven F., additional, Oláh, Judit, additional, Cserháti, Adrienne, additional, Wiesinger, Florian, additional, and Hideghéty, Katalin, additional

Published
2023
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17. HYpofractionated, Dose-redistributed RAdiotherapy with protons and photons to combat radiation-induced immunosuppression in head and neck squamous cell carcinoma: study protocol of the phase-I HYDRA trial

Author

Elbers, Joris B.W., primary, Gunsch, Pascal A., additional, Vulpen, Marco van, additional, Debets, Reno, additional, Keereweer, Stijn, additional, Meerten, Esther van, additional, Zindler, Jaap, additional, Norden, Yvette van, additional, Hoogeman, Mischa, additional, Verduijn, Gerda M., additional, Kroesen, Michiel, additional, and Nout, Remi A., additional

Published
2023
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19. Ex Vivo Functional Assay for Evaluating Treatment Response in Tumor Tissue of Head and Neck Squamous Cell Carcinoma

Author

Capala, Marta E., primary, Pachler, Katrin S., additional, Lauwers, Iris, additional, de Korte, Maarten A., additional, Verkaik, Nicole S., additional, Mast, Hetty, additional, Jonker, Brend P., additional, Sewnaik, Aniel, additional, Hardillo, Jose A., additional, Keereweer, Stijn, additional, Monserez, Dominiek, additional, Koljenovic, Senada, additional, Mostert, Bianca, additional, Verduijn, Gerda M., additional, Petit, Steven, additional, and van Gent, Dik C., additional

Published
2023
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20. Post radiation mucosal ulcer risk after a hypofractionated stereotactic boost and conventional fractionated radiotherapy for oropharyngeal carcinoma

Author

Verduijn, Gerda M., primary, Petit, Steven F., additional, Lauwers, Iris, additional, van Norden, Yvette, additional, Sijtsema, Nienke D., additional, Sewnaik, Aniel, additional, Mast, Hetty, additional, Capala, Marta, additional, Nout, Remi, additional, Baker, Sarah, additional, van Meerten, Esther, additional, Hoogeman, Mischa S., additional, van der Lugt, Aad, additional, and Heemsbergen, Wilma D., additional

Published
2022
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23. Protocol Letter: A multi-institutional retrospective case-control cohort investigating PREDiction models for mandibular OsteoRadioNecrosis in head and neck cancer (PREDMORN)

Author

Humbert-Vidan, Laia, primary, Hansen, Christian R., additional, Fuller, Clifton D., additional, Petit, Steven, additional, van der Schaaf, Arjen, additional, van Dijk, Lisanne V., additional, Verduijn, Gerda M., additional, Langendijk, Hans, additional, Muñoz-Montplet, Carles, additional, Heemsbergen, Wilma, additional, Witjes, Max, additional, Mohamed, Abdallah S.R., additional, Khan, Abdul A., additional, Marruecos Querol, Jordi, additional, Oliveras Cancio, Irene, additional, Patel, Vinod, additional, King, Andrew P., additional, Johansen, Jørgen, additional, and Guerrero Urbano, Teresa, additional

Published
2022
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27. The COMPLETE trial: HolistiC early respOnse assessMent for oroPharyngeaL cancEr paTiEnts; Protocol for an observational study

Author

Verduijn, Gerda M, primary, Capala, Marta E, additional, Sijtsema, Nienke D, additional, Lauwers, Iris, additional, Hernandez Tamames, Juan A, additional, Heemsbergen, Wilma D, additional, Sewnaik, Aniel, additional, Hardillo, Jose A, additional, Mast, Hetty, additional, van Norden, Yvette, additional, Jansen, Maurice P H M, additional, van der Lugt, Aad, additional, van Gent, Dik C, additional, Hoogeman, Mischa S, additional, Mostert, Bianca, additional, and Petit, Steven F, additional

Published
2022
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31. Post radiation mucosal ulcer risk after a hypofractionated stereotactic boost and conventional fractionated radiotherapy for oropharyngeal carcinoma.

Author

Verduijn, Gerda M., Petit, Steven F., Lauwers, Iris, van Norden, Yvette, Sijtsema, Nienke D., Sewnaik, Aniel, Mast, Hetty, Capala, Marta, Nout, Remi, Baker, Sarah, van Meerten, Esther, Hoogeman, Mischa S., van der Lugt, Aad, and Heemsbergen, Wilma D.

Subjects
*CANKER sores, *MULTIPLE regression analysis, *OROPHARYNGEAL cancer, *HEAD & neck cancer, *RETROSPECTIVE studies, *ACQUISITION of data, *RISK assessment, *CANCER patients, *COMPARATIVE studies, *MEDICAL records, *RADIATION doses, *DESCRIPTIVE statistics, *RADIOSURGERY, *RADIATION injuries, *ORAL mucosa, *PROGRESSION-free survival, *SQUAMOUS cell carcinoma, *LONGITUDINAL method, *PROPORTIONAL hazards models, *DISEASE risk factors
Abstract

Post radiation mucosal ulcers (PRMU) after treatment for oropharyngeal squamous cell carcinoma (OPSCC) can have a huge negative impact on patients' quality of life, but little is known concerning risk factors and the impact of fraction size. Therefore, the goal of this study was to determine the pattern of PRMU development and to identify risk factors after a hypofractionated stereotactic body radiotherapy boost (SBRT) compared to conventionally fractionated radiotherapy for OPSCC. We performed a retrospective cohort study (N = 332) of OPSCC patients with ≥ 1-year disease-free survival, treated with 46 Gy Intensity Modulated Radiotherapy (IMRT) (2 Gy fractions) followed by either an SBRT boost of 16.5 Gy (5.5 Gy fractions) (N = 180), or 24 Gy IMRT (2 Gy fractions) (N = 152). PRMU (grade ≥ 2) was scored when observed > three months after the last radiotherapy (RT) fraction (CTCAE v5.0). Potential risk factors were analyzed with Cox regression models using death as competing risk. Dose at the PRMU site was calculated by projecting delineated PRMU on the planning CT. All cases of PRMU (N = 64) occurred within 24 months; all were grade 2. The cumulative incidence at 2 years in the SBRT boost group was 26% (N = 46) vs. 12% (N = 18) for conventional fractionation (p = 0.003). Most PRMU developed within nine months (N = 48). PRMU occurring > nine months (N = 16) were mainly observed in the SBRT boost group (N = 15). Sex (p = 0.048), acute tube feeding (p = < 0.001), tumor subsite tonsil (p = 0.001), and N stage (p = 0.017) were associated with PRMU risk at multivariable regression in the hypofractionated SBRT boost group. All 25 delineated PRMU were located within the high dose regions. The risk of PRMU should be included in the cost benefit analysis when considering future research using a hypofractionated SBRT boost for OPSCC patients. [ABSTRACT FROM AUTHOR]

Published
2023
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35. P-64 Incidence and risk factors of osteoradionecrosis of the mandible after modern radiotherapy for oropharyngeal carcinoma

Author

Verduijn, Gerda M., primary, Sijtsema, Nienke D., additional, van Norden, Yvette, additional, Heemsbergen, Wilma D., additional, Mast, Hetty, additional, Sewnaik, Aniel, additional, Hove, Ivo ten, additional, Chin, Denzel, additional, Baker, Sarah, additional, van der Lugt, Aad, additional, Hoogeman, Mischa S., additional, and Petit, Steven, additional

Published
2021
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36. P-102 Dissemination patterns and chronology of distant metastasis affect survival of patients with head and neck squamous cell carcinoma

Author

Berzenji, Diako, primary, Sewnaik, Aniel, additional, Keereweer, Stijn, additional, Monserez, Dominiek A., additional, Verduijn, Gerda M., additional, van Meerten, Esther, additional, Mast, Hetty, additional, Mureau, Marc A.M., additional, van der Lugt, Aad, additional, Koljenovic, Senada, additional, Dronkers, Emilie A.C., additional, de Jong, Robert J. Baatenburg, additional, and Hardillo, Jose A., additional

Published
2021
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38. Deep-Learning-based Segmentation of Organs-at-Risk in the Head for MR-assisted Radiation Therapy Planning

Author

Ruskó, László, Capala, Marta E., Czipczer, Vanda, Kolozsvári, Bernadett, Deák-Karancsi, Borbála, Czabány, Renáta, Gyalai, Bence, Tan, Tao, Végváry, Zoltán, Borzasi, Emőke, Együd, Zsófia, Kószó, Renáta, Paczona, Viktor, Fodor, Emese, Bobb, Chad, Cozzini, Cristina, Kaushik, Sandeep, Darázs, Barbara, Verduijn, Gerda M., Pearson, Rachel, Maxwell, Ross, McCallum, Hazel, Hernandez Tamames, Juan A., Hideghéty, Katalin, Petit, Steven F., Wiesinger, Florian, Douplik, Alexandre, Fred, Ana, Gamboa, Hugo, Radiotherapy, and Radiology & Nuclear Medicine

Subjects
medicine.medical_specialty, business.industry, Head (linguistics), Deep learning, Medicine, Segmentation, Artificial intelligence, Radiology, business, Radiation treatment planning
Abstract

Segmentation of organs-at-risk (OAR) in MR images has several clinical applications; including radiation therapy (RT) planning. This paper presents a deep-learning-based method to segment 15 structures in the head region. The proposed method first applies 2D U-Net models to each of the three planes (axial, coronal, sagittal) to roughly segment the structure. Then, the results of the 2D models are combined into a fused prediction to localize the 3D bounding box of the structure. Finally, a 3D U-Net is applied to the volume of the bounding box to determine the precise contour of the structure. The model was trained on a public dataset and evaluated on both public and private datasets that contain T2-weighted MR scans of the head-and-neck region. For all cases the contour of each structure was defined by operators trained by expert clinical delineators. The evaluation demonstrated that various structures can be accurately and efficiently localized and segmented using the presented framework. The contours generated by the proposed method were also qualitatively evaluated. The majority (92%) of the segmented OARs was rated as clinically useful for radiation therapy.

Published
2021

42. Survival of patients with head and neck cancer with metachronous multiple primary tumors is surprisingly favorable

Author

Bugter, Oisín, primary, Iwaarden, Dirk L.P., additional, Dronkers, Emilie A.C., additional, Herdt, Martine J., additional, Wieringa, Marjan H., additional, Verduijn, Gerda M., additional, Mureau, Marc A.M., additional, Hove, Ivo, additional, Meerten, Esther, additional, Hardillo, José A., additional, and Baatenburg de Jong, Robert J., additional

Published
2019
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44. An optimal acquisition and post‐processing pipeline for hybrid IVIM‐DKI in head and neck.

Author

Sijtsema, Nienke D., Petit, Steven F., Poot, Dirk H. J., Verduijn, Gerda M., Lugt, Aad, Hoogeman, Mischa S., and Hernandez‐Tamames, Juan A.

Subjects
DIFFUSION coefficients, PIPELINES, NECK, KURTOSIS, RECORDING & registration
Abstract

Purpose: To optimize the diffusion‐weighting b values and postprocessing pipeline for hybrid intravoxel incoherent motion diffusion kurtosis imaging in the head and neck region. Methods: Optimized diffusion‐weighting b value sets ranging between 5 and 30 b values were constructed by optimizing the Cramér‐Rao lower bound of the hybrid intravoxel incoherent motion diffusion kurtosis imaging model. With this model, the perfusion fraction, pseudodiffusion coefficient, diffusion coefficient, and kurtosis were estimated. Sixteen volunteers were scanned with a reference b value set and 3 repeats of the optimized sets, of which 1 with volunteers swallowing on purpose. The effects of (1) b value optimization and number of b values, (2) registration type (none vs. intervolume vs. intra‐ and intervolume registration), and (3) manual swallowing artifact rejection on the parameter precision were assessed. Results: The SD was higher in the reference set for perfusion fraction, diffusion coefficient, and kurtosis by a factor of 1.7, 1.5, and 2.3 compared to the optimized set, respectively. A smaller SD (factor 0.7) was seen in pseudodiffusion coefficient. The sets containing 15, 20, and 30 b values had comparable repeatability in all parameters, except pseudodiffusion coefficient, for which set size 30 was worse. Equal repeatability for the registration approaches was seen in all parameters of interest. Swallowing artifact rejection removed the bias when present. Conclusion: To achieve optimal hybrid intravoxel incoherent motion diffusion kurtosis imaging in the head and neck region, b value optimization and swallowing artifact image rejection are beneficial. The optimized set of 15 b values yielded the optimal protocol efficiency, with a precision comparable to larger b value sets and a 50% reduction in scan time. [ABSTRACT FROM AUTHOR]

Published
2021
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47. Heat-induced BRCA2 degradation in human tumours provides rationale for hyperthermia-PARP-inhibitor combination therapies

Author

van den Tempel, Nathalie, primary, Odijk, Hanny, additional, van Holthe, Netteke, additional, Naipal, Kishan, additional, Raams, Anja, additional, Eppink, Berina, additional, van Gent, Dik C., additional, Hardillo, Jose, additional, Verduijn, Gerda M., additional, Drooger, Jan C., additional, van Rhoon, Gerard C., additional, Smedts, Dineke (H.) P.M., additional, van Doorn, Helena C., additional, Boormans, Joost L., additional, Jager, Agnes, additional, Franckena, Martine, additional, and Kanaar, Roland, additional

Published
2017
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50. Heat-induced BRCA2 degradation in human tumours provides rationale for hyperthermia-PARP-inhibitor combination therapies.

Author

van den Tempel, Nathalie, Odijk, Hanny, van Holthe, Netteke, Naipal, Kishan, Raams, Anja, Eppink, Berina, van Gent, Dik C., Hardillo, Jose, Verduijn, Gerda M., Drooger, Jan C., van Rhoon, Gerard C., Smedts, Dineke (H.) P.M., van Doorn, Helena C., Boormans, Joost L., Jager, Agnes, Franckena, Martine, and Kanaar, Roland

Subjects
FEVER, CANCER chemotherapy, CANCER treatment, CANCER cells, BRCA genes
Abstract

Purpose: Hyperthermia (40-44 °C) effectively sensitises tumours to radiotherapy by locally altering tumour biology. One of the effects of heat at the cellular level is inhibition of DNA repair by homologous recombination via degradation of the BRCA2-protein. This suggests that hyperthermia can expand the group of patients that benefit from PARP-inhibitors, a drug exploiting homologous recombination deficiency. Here, we explore whether the molecular mechanisms that cause heat-mediated degradation of BRCA2 are conserved in cell lines from various origins and, most importantly, whether, BRCA2 protein levels can be attenuated by heat in freshly biopted human tumours. Experimental design: Cells from four established cell lines and from freshly biopsied material of cervical (15), head- and neck (9) or bladder tumours (27) were heated to 42 °C for 60 min ex vivo. In vivo hyperthermia was studied by taking two biopsies of the same breast or cervical tumour: one before and one after treatment. BRCA2 protein levels were measured by immunoblotting. Results: We found decreased BRCA2-levels after hyperthermia in all established cell lines and in 91% of all tumours treated ex vivo. For tumours treated with hyperthermia in vivo, technical issues and intra-tumour heterogeneity prevented obtaining interpretable results. Conclusions: This study demonstrates that heat-mediated degradation of BRCA2 occurs in tumour material directly derived from patients. Although BRCA2-degradation may not be a practical biomarker for heat deposition in situ, it does suggest that application of hyperthermia could be an effective method to expand the patient group that could benefit from PARP-inhibitors. [ABSTRACT FROM AUTHOR]

Published
2018
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