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2. Greater male variability in daily energy expenditure develops through puberty.

Author

Haisma, Hinke, Hambly, Catherine, Hoffman, Daniel, Hoos, Marije, Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek, Katzmarzyk, Peter, Kempen, Kitty, Kimura, Misaka, Kraus, William, Kriengsinyos, Wantanee, Kuriyan, Rebecca, Kushner, Robert, Lambert, Estelle, Lanerolle, Pulani, Larsson, Christel, Lessan, Nader, Löf, Marie, Martin, Corby, Matsiko, Eric, Meijer, Gerwin, Morehen, James, Morton, James, Must, Aviva, Neuheuser, Marian, Nicklas, Theresa, Ojiambo, Robert, Pietilainen, Kirsi, Pitsiladis, Yannis, Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross, Rabinovich, Roberto, Racette, Susan, Raichen, David, Ravussin, Eric, Redman, Leanne, Reilly, John, Reynolds, Rebecca, Roberts, Susan, Rood, Jennifer, Samaranayake, Dulani, Sardinha, Luís, Scuitt, Albertine, Silva, Analiza, Sinha, Srishti, Sjödin, Anders, Stice, Eric, Stunkard, Albert, Urlacher, Samuel, Valencia, Mauro, Valenti, Giulio, van Etten, Ludo, Van Mil, Edgar, Verbunt, Jeanine, Wells, Jonathan, Wilson, George, Wood, Brian, Yoshida, Tsukasa, Zhang, Xueying, Murphy-Alford, Alexia, Loechl, Cornelia, Luke, Amy, Pontzer, Herman, Sagayama, Hiroyuki, Westerterp, Klaas, Wong, William, Yamada, Yosuke, Speakman, John, Halsey, Lewis, Careau, Vincent, Ainslie, Philip, Alemán-Mateo, Heliodoro, Andersen, Lene, Anderson, Liam, Arab, Leonore, Baddou, Issad, Bandini, Linda, Bedu-Addo, Kweku, Blaak, Ellen, Blanc, Stephane, Bonomi, Alberto, Bouten, Carlijn, Bovet, Pascal, Brage, Soren, Buchowski, Maciej, Butte, Nancy, Camps, Stephan, Casper, Regian, Close, Graeme, Colbert, Lisa, Cooper, Jamie, Cooper, Richard, Dabare, Prasangi, Das, Sai, Davies, Peter, Deb, Sanjoy, and Nyström, Christine

Subjects
age, height, inter-individual variation, morphometry, weight, Adolescent, Young Adult, Female, Humans, Male, Adult, Puberty, Sexual Behavior, Reproduction, Energy Metabolism, Phenotype
Abstract

There is considerably greater variation in metabolic rates between men than between women, in terms of basal, activity and total (daily) energy expenditure (EE). One possible explanation is that EE is associated with male sexual characteristics (which are known to vary more than other traits) such as musculature and athletic capacity. Such traits might be predicted to be most prominent during periods of adolescence and young adulthood, when sexual behaviour develops and peaks. We tested this hypothesis on a large dataset by comparing the amount of male variation and female variation in total EE, activity EE and basal EE, at different life stages, along with several morphological traits: height, fat free mass and fat mass. Total EE, and to some degree also activity EE, exhibit considerable greater male variation (GMV) in young adults, and then a decreasing GMV in progressively older individuals. Arguably, basal EE, and also morphometrics, do not exhibit this pattern. These findings suggest that single male sexual characteristics may not exhibit peak GMV in young adulthood, however total and perhaps also activity EE, associated with many morphological and physiological traits combined, do exhibit GMV most prominently during the reproductive life stages.

Published
2023

3. Correction: Role and promise of health policy and systems research in integrating rehabilitation into the health systems

Author

Ghafar, Abdul, Bachani, Abdulgafoor M., Hyder, Adnan A., Cieza, Alarcos, Bhangu, Aneel, Bussières, André, Sanchez-Ramirez, Diana C., Gandhi, Dorcas B. C., Verbunt, Jeanine, Rasanathan, Kumanan, Gustafsson, Louise, Côté, Pierre, Reebye, Rajiv, De la Cerna-Luna, Roger, Negrini, Stefano, Frontera, Walter R., and Kamalakannan, Sureshkumar

Published
2024
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4. Role and promise of health policy and systems research in integrating rehabilitation into the health systems

Author

Ghaffar, Abdul, Bachani, Abdulgafoor M., Hyder, Adnan A., Cieza, Alarcos, Bhangu, Aneel, Bussières, André, Sanchez-Ramirez, Diana C., Gandhi, Dorcas B. C., Verbunt, Jeanine, Rasanathan, Kumanan, Gustafsson, Louise, Côté, Pierre, Reebye, Rajiv, De la Cerna-Luna, Roger, Negrini, Stefano, Frontera, Walter R., and Kamalakannan, Sureshkumar

Published
2024
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10. Decline in Isotope Dilution Space Ratio Above Age 60 Could Affect Energy Estimates Using the Doubly Labeled Water Method

Author

Wong, William W, Speakman, John R, Ainslie, Philip N, Anderson, Liam J, Arab, Leonore, Baddou, Issad, Bedu-Addo, Kweku, Blaak, Ellen E, Blanc, Stephane, Bonomi, Alberto G, Bouten, Carlijn VC, Bovet, Pascal, Buchowski, Maciej S, Butte, Nancy F, Camps, Stefan G, Casper, Regina, Close, Graeme L, Colbert, Lisa H, Cooper, Jamie A, Das, Sai K, Davies, Peter SW, Eaton, Simon, Ekelund, Ulf, Hambly, Catherine, El Hamdouchi, Asmaa, Entringer, Sonja, Fudge, Barry W, Gillingham, Melanie, Goris, Annelies H, Gurven, Micheal, Hoos, Marije B, Hu, Sumei, Joosen, Annemiek, Katzmarzyk, Peter T, Kempen, Kitty P, Kimura, Misaka, Kraus, William E, Kushner, Robert F, Larsson, Christel L, Morehen, James C, Morton, James P, Neuhouser, Marian L, Nicklas, Theresa A, Ojiambo, Robert M, Pietilainen, Kirsi H, Pitsiladis, Yannis P, Plasqui, Guy, Prentice, Ross L, Rabinovich, Roberto, Racette, Susan B, Raichen, David A, Redman, Leanne, Ravussin, Eric, Reilly, John J, Roberts, Susan, Scuitt, Albertine J, Sjödin, Anders M, Stice, Eric, Urlacher, Samuel S, Valenti, Giulio, van Etten, Ludo M, Van Mil, Edgar A, Verbunt, Jeanine A, Wells, Jonathan CK, Wilson, George, Yoshida, Tsukasa, Zhang, Xueying, Loechl, Cornelia U, Luke, Amy, Murphy-Alford, Alexia J, Pontzer, Herman, Sagayama, Hiroyuki, Rood, Jennifer C, Schoeller, Dale A, Westerterp, Klaas R, and Yamada, Yosuke

Published
2024
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14. Human total, basal and activity energy expenditures are independent of ambient environmental temperature

Author

Andersen, Lene F., Anderson, Liam J., Arab, Lenore, Baddou, Issad, Addo, Bedu, Blanc, Stephane, Bonomi, Alberto, Bouten, Carlijn V.C., Bovet, Pascal, Branth, Stefan, De Bruin, Niels C., Butte, Nancy F., Colbert, Lisa H., Camps, Stephan G., Dutman, Alice E., Eaton, Simon D., Ekelund, Ulf, Entringer, Sonja, Ebbeling, Cara, Elmståhl, Sölve, Fogelholm, Mikael, Forrester, Terrence, Fudge, Barry W., Harris, Tamara, Heijligenberg, Rik, Goris, Annelies H., Hambly, Catherine, Hoos, Marije B., Jorgensen, Hans U., Joosen, Annemiek M., Kempen, Kitty P., Kimura, Misaka, Kriengsinyos, Watanee, Lambert, Estelle V., Larsson, Christel L., Lessan, Nader, Ludwig, David S., McCloskey, Margaret, Medin, Anine C., Meijer, Gerwin A., Matsiko, Eric, Melse-Boonstra, Alida, Morehen, James C., Morton, James P., Nicklas, Theresa A., Pannemans, Daphne L., Pietiläinen, Kirsi H., Philippaerts, Renaat M., Rabinovich, Roberto A., Reilly, John J., Rothenberg, Elisabet M., Schuit, Albertine J., Schulz, Sabine, Sjödin, Anders M., Subar, Amy, Tanskanen, Minna, Uauy, Ricardo, Valenti, Giulio, Van Etten, Ludo M., Berg-Emons, Rita Van den, Van Gemert, Wim G., Velthuis-te Wierik, Erica J., Verboeket-van de Venne, Wilhelmine W., Verbunt, Jeanine A., Wells, Jonathan C.K., Wilson, George, Zhang, Xueying, Yamada, Yosuke, Sagayama, Hiroyuki, Ainslie, Philip N., Blaak, Ellen E., Buchowski, Maciej S., Close, Graeme L., Cooper, Jamie A., Das, Sai Krupa, Dugas, Lara R., Gurven, Michael, El Hamdouchi, Asmaa, Hu, Sumei, Joonas, Noorjehan, Katzmarzyk, Peter, Kraus, William E., Kushner, Robert F., Leonard, William R., Martin, Corby K., Meijer, Erwin P., Neuhouser, Marian L., Ojiambo, Robert M., Pitsiladis, Yannis P., Plasqui, Guy, Prentice, Ross L., Racette, Susan B., Ravussin, Eric, Redman, Leanne M., Reynolds, Rebecca M., Roberts, Susan B., Sardinha, Luis B., Silva, Analiza M., Stice, Eric, Urlacher, Samuel S., Van Mil, Edgar A., Wood, Brian M., Murphy-Alford, Alexia J., Loechl, Cornelia, Luke, Amy H., Rood, Jennifer, Schoeller, Dale A., Westerterp, Klaas R., Wong, William W., Pontzer, Herman, and Speakman, John R.

Published
2022
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15. The effects of a single bout of high-intense strength exercise on cognitive function and postural dual-task control in older adults.

Author

Vints, Wouter A. J., Ghafelzadeh Ahwaz, Feryal, Westhof-Jacobs, Charlotte, Drozdova-Statkevičienė, Margarita, Česnaitienė, Vida J., Ziv, Gal, Pauwels, Lisa, Levin, Oron, Verbunt, Jeanine, and Masiulis, Nerijus

Subjects
COGNITIVE processing speed, COGNITIVE ability, NEUROPSYCHOLOGICAL tests, RESISTANCE training, OLDER people, ISOMETRIC exercise
Abstract

In this study we aimed to test if acute strength exercise would induce cognitive improvements. Secondarily, we examined the relationship between exercise-induced changes in cognitive function and postural dual-task control. Thirty-seven cognitively intact, non-faller older adults (≥60 years) were nonrandomly allocated to strength exercise or control. Strength exercise consisted of Smith machine squats (one session, 3 × 3reps at 90%, 95%, and 100% one-repetition maximum). Control participants held seated rest for 45 min. Cognitive functions, recognition (memory search), working memory (mathematical processing), processing speed (2-choice reaction time), and postural dual-task control were tested before and immediately after exercise or control using the Automated Neuropsychological Assessment Metrics-4 (ANAM4) battery and a mathematical counting task while maintaining a tandem Romberg stance with eyes open on a force plate. Outcome measures were response time and performance index (100 × [accuracy/response time]) on the ANAM4 tests and sway activity and entropy during the postural dual-task. We found a non-significant improvement with moderate effect size in performance index on the mathematical processing task of experimental participants compared to control participants (p = 0.145, $\eta _p^2$ η p 2 = 0.060). Improvements in the mathematical processing task over time in the control group were associated with increased sway activity during the postural dual-task. No significant associations were found between changes in cognitive function and changes in postural control in the experimental group. Ultimately, our results may direct researchers and healthcare professionals in designing the optimal exercise treatment to improve cognitive function and postural control in older adults. [ABSTRACT FROM AUTHOR]

Published
2024
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21. The impact of 12 weeks of resistance exercise on hippocampus structural and neurochemical characteristics in older adults: Evidence from MRI and 1H-MRS findings

Author

Gökçe, Evrim, primary, Vints, Wouter A.J., additional, Šeikinaitė, Julija, additional, Kušleikienė, Simona, additional, Seduikiene, Milda, additional, Valatkeviciene, Kristina, additional, Gleiznienė, Rymantė, additional, Česnaitienė, Vida J., additional, Verbunt, Jeanine, additional, Levin, Oron, additional, and Masiulis, Nerijus, additional

Published
2023
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24. The effects of a single bout of high-intense strength exercise on cognitive function and postural dual-task control in older adults

Author

Vints, Wouter A. J., primary, Ghafelzadeh Ahwaz, Feryal, additional, Westhof-Jacobs, Charlotte, additional, Drozdova-Statkevičienė, Margarita, additional, Česnaitienė, Vida J., additional, Ziv, Gal, additional, Pauwels, Lisa, additional, Levin, Oron, additional, Verbunt, Jeanine, additional, and Masiulis, Nerijus, additional

Published
2023
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31. Greater male variability in daily energy expenditure develops through puberty

Author

Halsey, Lewis G., Careau, Vincent, Ainslie, Philip N., Alemán-Mateo, Heliodoro, Andersen, Lene F., Anderson, Liam J., Arab, Leonore, Baddou, Issad, Bandini, Linda, Bedu-Addo, Kweku, Blaak, Ellen E., Blanc, Stephane, Bonomi, Alberto G., Bouten, Carlijn V.C., Bovet, Pascal, Brage, Soren, Buchowski, Maciej S., Butte, Nancy, Camps, Stephan G., Casper, Regian, Close, Graeme L., Colbert, Lisa H., Cooper, Jamie A., Cooper, Richard, Dabare, Prasangi, Das, Sai Krupa, Davies, Peter S.W., Deb, Sanjoy, Nyström, Christine Delisle, Dietz, William, Dugas, Lara R., Eaton, Simon, Ekelund, Ulf, Hamdouchi, Asmaa El, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W., Gillingham, Melanie, Goris, Annelies H., Gurven, Michael, Haisma, Hinke, Hambly, Catherine, Hoffman, Daniel, Hoos, Marije B., Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek, Katzmarzyk, Peter, Kempen, Kitty P., Kimura, Misaka, Kraus, William E., Kriengsinyos, Wantanee, Kuriyan, Rebecca, Kushner, Robert F., Lambert, Estelle V., Lanerolle, Pulani, Larsson, Christel L., Lessan, Nader, Löf, Marie, Martin, Corby, Matsiko, Eric, Meijer, Gerwin A., Morehen, James C., Morton, James P., Must, Aviva, Neuheuser, Marian, Nicklas, Theresa A., Ojiambo, Robert M., Pietilainen, Kirsi H., Pitsiladis, Yannis P., Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross L., Rabinovich, Roberto, Racette, Susan B., Raichen, David A., Ravussin, Eric, Redman, Leanne, Reilly, John J., Reynolds, Rebecca, Roberts, Susan, Rood, Jennifer C., Samaranayake, Dulani, Sardinha, Luís B., Scuitt, Albertine J., Silva, Analiza M., Sinha, Srishti, Sjödin, Anders M., Stice, Eric, Stunkard, Albert, Urlacher, Samuel S., Valencia, Mauro Eduardo, Valenti, Giulio, Van Etten, Ludo M., Van Mil, Edgar A., Verbunt, Jeanine A., Wells, Jonathan C.K., Wilson, George, Wood, Brian, Yoshida, Tsukasa, Zhang, Xueying, Murphy-Alford, Alexia, Loechl, Cornelia, Luke, Amy, Pontzer, Herman, Rood, Jennifer, Sagayama, Hiroyuki, Westerterp, Klaas R., Wong, William W., Yamada, Yosuke, Speakman, John R., Halsey, Lewis G., Careau, Vincent, Ainslie, Philip N., Alemán-Mateo, Heliodoro, Andersen, Lene F., Anderson, Liam J., Arab, Leonore, Baddou, Issad, Bandini, Linda, Bedu-Addo, Kweku, Blaak, Ellen E., Blanc, Stephane, Bonomi, Alberto G., Bouten, Carlijn V.C., Bovet, Pascal, Brage, Soren, Buchowski, Maciej S., Butte, Nancy, Camps, Stephan G., Casper, Regian, Close, Graeme L., Colbert, Lisa H., Cooper, Jamie A., Cooper, Richard, Dabare, Prasangi, Das, Sai Krupa, Davies, Peter S.W., Deb, Sanjoy, Nyström, Christine Delisle, Dietz, William, Dugas, Lara R., Eaton, Simon, Ekelund, Ulf, Hamdouchi, Asmaa El, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W., Gillingham, Melanie, Goris, Annelies H., Gurven, Michael, Haisma, Hinke, Hambly, Catherine, Hoffman, Daniel, Hoos, Marije B., Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek, Katzmarzyk, Peter, Kempen, Kitty P., Kimura, Misaka, Kraus, William E., Kriengsinyos, Wantanee, Kuriyan, Rebecca, Kushner, Robert F., Lambert, Estelle V., Lanerolle, Pulani, Larsson, Christel L., Lessan, Nader, Löf, Marie, Martin, Corby, Matsiko, Eric, Meijer, Gerwin A., Morehen, James C., Morton, James P., Must, Aviva, Neuheuser, Marian, Nicklas, Theresa A., Ojiambo, Robert M., Pietilainen, Kirsi H., Pitsiladis, Yannis P., Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross L., Rabinovich, Roberto, Racette, Susan B., Raichen, David A., Ravussin, Eric, Redman, Leanne, Reilly, John J., Reynolds, Rebecca, Roberts, Susan, Rood, Jennifer C., Samaranayake, Dulani, Sardinha, Luís B., Scuitt, Albertine J., Silva, Analiza M., Sinha, Srishti, Sjödin, Anders M., Stice, Eric, Stunkard, Albert, Urlacher, Samuel S., Valencia, Mauro Eduardo, Valenti, Giulio, Van Etten, Ludo M., Van Mil, Edgar A., Verbunt, Jeanine A., Wells, Jonathan C.K., Wilson, George, Wood, Brian, Yoshida, Tsukasa, Zhang, Xueying, Murphy-Alford, Alexia, Loechl, Cornelia, Luke, Amy, Pontzer, Herman, Rood, Jennifer, Sagayama, Hiroyuki, Westerterp, Klaas R., Wong, William W., Yamada, Yosuke, and Speakman, John R.

Abstract

There is considerably greater variation in metabolic rates between men than between women, in terms of basal, activity and total (daily) energy expenditure (EE). One possible explanation is that EE is associated with male sexual characteristics (which are known to vary more than other traits) such as musculature and athletic capacity. Such traits might be predicted to be most prominent during periods of adolescence and young adulthood, when sexual behaviour develops and peaks. We tested this hypothesis on a large dataset by comparing the amount of male variation and female variation in total EE, activity EE and basal EE, at different life stages, along with several morphological traits: height, fat free mass and fat mass. Total EE, and to some degree also activity EE, exhibit considerable greater male variation (GMV) in young adults, and then a decreasing GMV in progressively older individuals. Arguably, basal EE, and also morphometrics, do not exhibit this pattern. These findings suggest that single male sexual characteristics may not exhibit peak GMV in young adulthood, however total and perhaps also activity EE, associated with many morphological and physiological traits combined, do exhibit GMV most prominently during the reproductive life stages.

Published
2023

43. Acceptability, usability and feasibility of experienced sampling method in chronic secondary pain syndromes.

Author

Damci, Aysun, Hoeijmakers, Janneke G. J., den Hollande, Marlies, Köke, Albère, de Mooij, Marion, Faber, Catharina G., and Verbunt, Jeanine A. M. C. F.

Subjects
CHRONIC pain, SAMPLING methods, SYNDROMES, MUSCULOSKELETAL pain, SOCIAL contact
Abstract

Background: In chronic pain syndromes, symptoms can fluctuate and change over time. Standard questionnaires cannot register these fluctuations. Nonetheless, the experience sampling method (ESM) is developed to collect momentary measurements of everyday complaints, tracing fluctuations in symptoms and disabling factors over time. Although valuable information can be collected in this way, assessment may also be a burden. This study aimed to investigate the acceptability, usability, and feasibility of ESM in chronic secondary pain syndromes, in a single-center study in the Netherlands. Methods: A prospective observational study with repeated measurements was conducted in patients with chronic secondary neuropathic and musculoskeletal pain syndromes, including small fiber neuropathy, spinal cord injury, and rheumatoid disorder. Results: Thirty-four participants were included and filled in the ESM, of whom 19 were diagnosed with small fiber neuropathy, 11 with spinal cord injury, and 4 with a rheumatoid disorder. The mean age was 54.7 ± 13.9 years (range: 23-77) of whom 52.9% were female. In total, 19 participants filled in the general and user-friendliness evaluation about the acceptability and usability of the ESM. The general evaluation showed no influence of ESM on participants' social contacts (mean 1.47, SD 1.12), activities (mean 1.74, SD 1.44), and mood (mean 1.89, SD 1.59). The answers options of ESM were a good representation of the experiences of participants (mean 4.58, SD 1.77). Regarding feasibility, the overall response rate for answering the beep signals of ESM was 44.5% in total. The missing rate per person varied from 13% to 97% with a median of 54.1%. Conclusion: The general evaluation and the user-friendliness revealed sufficient outcomes in favor of the ESM application. ESM seems a promising measurement tool to use in secondary chronic pain syndromes. [ABSTRACT FROM AUTHOR]

Published
2023
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45. Human total, basal and activity energy expenditures are independent of ambient environmental temperature

Author

Zhang, Xueying, primary, Yamada, Yosuke, additional, Sagayama, Hiroyuki, additional, Ainslie, Philip N., additional, Blaak, Ellen E., additional, Buchowski, Maciej S., additional, Close, Graeme L., additional, Cooper, Jamie A., additional, Das, Sai Krupa, additional, Dugas, Lara R., additional, Gurven, Michael, additional, El Hamdouchi, Asmaa, additional, Hu, Sumei, additional, Joonas, Noorjehan, additional, Katzmarzyk, Peter, additional, Kraus, William E., additional, Kushner, Robert F., additional, Leonard, William R., additional, Martin, Corby K., additional, Meijer, Erwin P., additional, Neuhouser, Marian L., additional, Ojiambo, Robert M., additional, Pitsiladis, Yannis P., additional, Plasqui, Guy, additional, Prentice, Ross L., additional, Racette, Susan B., additional, Ravussin, Eric, additional, Redman, Leanne M., additional, Reynolds, Rebecca M., additional, Roberts, Susan B., additional, Sardinha, Luis B., additional, Silva, Analiza M., additional, Stice, Eric, additional, Urlacher, Samuel S., additional, Van Mil, Edgar A., additional, Wood, Brian M., additional, Murphy-Alford, Alexia J., additional, Loechl, Cornelia, additional, Luke, Amy H., additional, Rood, Jennifer, additional, Schoeller, Dale A., additional, Westerterp, Klaas R., additional, Wong, William W., additional, Pontzer, Herman, additional, Speakman, John R., additional, Andersen, Lene F., additional, Anderson, Liam J., additional, Arab, Lenore, additional, Baddou, Issad, additional, Addo, Bedu, additional, Blanc, Stephane, additional, Bonomi, Alberto, additional, Bouten, Carlijn V.C., additional, Bovet, Pascal, additional, Branth, Stefan, additional, De Bruin, Niels C., additional, Butte, Nancy F., additional, Colbert, Lisa H., additional, Camps, Stephan G., additional, Dutman, Alice E., additional, Eaton, Simon D., additional, Ekelund, Ulf, additional, Entringer, Sonja, additional, Ebbeling, Cara, additional, Elmståhl, Sölve, additional, Fogelholm, Mikael, additional, Forrester, Terrence, additional, Fudge, Barry W., additional, Harris, Tamara, additional, Heijligenberg, Rik, additional, Goris, Annelies H., additional, Hambly, Catherine, additional, Hoos, Marije B., additional, Jorgensen, Hans U., additional, Joosen, Annemiek M., additional, Kempen, Kitty P., additional, Kimura, Misaka, additional, Kriengsinyos, Watanee, additional, Lambert, Estelle V., additional, Larsson, Christel L., additional, Lessan, Nader, additional, Ludwig, David S., additional, McCloskey, Margaret, additional, Medin, Anine C., additional, Meijer, Gerwin A., additional, Matsiko, Eric, additional, Melse-Boonstra, Alida, additional, Morehen, James C., additional, Morton, James P., additional, Nicklas, Theresa A., additional, Pannemans, Daphne L., additional, Pietiläinen, Kirsi H., additional, Philippaerts, Renaat M., additional, Rabinovich, Roberto A., additional, Reilly, John J., additional, Rothenberg, Elisabet M., additional, Schuit, Albertine J., additional, Schulz, Sabine, additional, Sjödin, Anders M., additional, Subar, Amy, additional, Tanskanen, Minna, additional, Uauy, Ricardo, additional, Valenti, Giulio, additional, Van Etten, Ludo M., additional, Berg-Emons, Rita Van den, additional, Van Gemert, Wim G., additional, Velthuis-te Wierik, Erica J., additional, Verboeket-van de Venne, Wilhelmine W., additional, Verbunt, Jeanine A., additional, Wells, Jonathan C.K., additional, and Wilson, George, additional

Published
2022
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50. Inflammatory Blood Biomarker Kynurenine Is Linked With Elevated Neuroinflammation and Neurodegeneration in Older Adults

Author

Vints, Wouter A. J., Kušleikiene, Simona, Sheoran, Samrat, Šarkinaite, Milda, Valatkevičiene, Kristina, Gleizniene, Rymante, Kvedaras, Mindaugas, Pukenas, Kazimieras, Himmelreich, Uwe, Cesnaitiene, Vida J., Levin, Oron, Verbunt, Jeanine, Masiulis, Nerijus, Revalidatiegeneeskunde, RS: CAPHRI - R3 - Functioning, Participating and Rehabilitation, and Frontiers Media SA

Subjects
cognition, SYSTEMIC INFLAMMATION, obesity, neurochemicals, INTERLEUKIN-6, LEUKOCYTE MOBILIZATION, aging, brain imaging, gray matter volume, cerebral metabolite ratios, inflammation, MAGNETIC-RESONANCE-SPECTROSCOPY, METABOLISM, COGNITIVE FUNCTION, RAT-BRAIN, POSTERIOR CINGULATE, Psychiatry and Mental health, INJURY, BRAIN COMMUNICATION
Abstract

Rationale and ObjectivesPro-inflammatory processes have been argued to play a role in conditions associated with cognitive decline and neurodegeneration, like aging and obesity. Only a limited number of studies have tried to measure both peripheral and central biomarkers of inflammation and examined their interrelationship. The primary aim of this study was to examine the hypothesis that chronic peripheral inflammation would be associated with neurometabolic changes that indicate neuroinflammation (the combined elevation of myoinositol and choline), brain gray matter volume decrease, and lower cognitive functioning in older adults.Materials and MethodsSeventy-four older adults underwent bio-impedance body composition analysis, cognitive testing with the Montreal Cognitive Assessment (MoCA), blood serum analysis of inflammatory markers interleukin-6 (IL-6) and kynurenine, magnetic resonance imaging (MRI), and proton magnetic resonance spectroscopy (1H-MRS) of the brain. Neurometabolic findings from both Tarquin and LCModel 1H-MRS post-processing software packages were compared. The regions of interest for MRI and 1H-MRS measurements were dorsal posterior cingulate cortex (DPCC), left hippocampal cortex (HPC), left medial temporal cortex (MTC), left primary sensorimotor cortex (SM1), and right dorsolateral prefrontal cortex (DLPFC).ResultsElevated serum kynurenine levels were associated with signs of neuroinflammation, specifically in the DPCC, left SM1 and right DLPFC, and signs of neurodegeneration, specifically in the left HPC, left MTC and left SM1, after adjusting for age, sex and fat percentage (fat%). Elevated serum IL-6 levels were associated with increased Glx levels in left HPC, left MTC, and right DLPFC, after processing the 1H-MRS data with Tarquin. Overall, the agreement between Tarquin and LCModel results was moderate-to-strong for tNAA, tCho, mIns, and tCr, but weak to very weak for Glx. Peripheral inflammatory markers (IL-6 and kynurenine) were not associated with older age, higher fat%, decreased brain gray matter volume loss or decreased cognitive functioning within a cohort of older adults.ConclusionOur results suggest that serum kynurenine may be used as a peripheral inflammatory marker that is associated with neuroinflammation and neurodegeneration, although not linked to cognition. Future studies should consider longitudinal analysis to assess the causal inferences between chronic peripheral and neuroinflammation, brain structural and neurometabolic changes, and cognitive decline in aging.

Published
2022

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