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1. Long-Term Outcome of Immediate Versus Postponed Intervention in Patients With Infected Necrotizing Pancreatitis (POINTER): Multicenter Randomized Trial

Author

Van Veldhuisen, Charlotte L., Sissingh, Noor J., Boxhoorn, Lotte, van Dijk, Sven M., van Grinsven, Janneke, Verdonk, Robert C., Boermeester, Marja A., Bouwense, Stefan A.W., Bruno, Marco J., Cappendijk, Vincent C., van Duijvendijk, Peter, van Eijck, Casper H J., Fockens, Paul, van Goor, Harry, Hadithi, Muhammed, Haveman, Jan Willem, Jacobs, Maarten A.J.M., Jansen, Jeroen M., Kop, Marnix P.M., Manusama, Eric R., Mieog, J. Sven D., Molenaar, I. Quintus, Nieuwenhuijs, Vincent B., Poen, Alexander C., Poley, Jan-Werner, Quispel, Rutger, Römkens, Tessa E.H., Schwartz, Matthijs P., Seerden, Tom C., Dijkgraaf, Marcel G.W., Stommel, Martijn W.J., Straathof, Jan Willem A., Venneman, Niels G., Voermans, Rogier P., van Hooft, Jeanin E., van Santvoort, Hjalmar C., and Besselink, Marc G.

Published
2024
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2. Endoscopic ultrasonography-guided gastroenterostomy versus surgical gastrojejunostomy for palliation of malignant gastric outlet obstruction (ENDURO): study protocol for a randomized controlled trial

Author

Kastelijn, Janine B., van de Pavert, Yorick L., Besselink, Marc G., Fockens, Paul, Voermans, Rogier P., van Wanrooij, Roy L. J., de Wijkerslooth, Thomas R., Curvers, Wouter L., de Hingh, Ignace H. J. T., Bruno, Marco J., Koerkamp, Bas Groot, Patijn, Gijs A., Poen, Alexander C., van Hooft, Jeanin E., Inderson, Akin, Mieog, J. Sven D., Poley, Jan-Werner, Bijlsma, Alderina, Lips, Daan J., Venneman, Niels G., Verdonk, Robert C., van Dullemen, Hendrik M., Hoogwater, Frederik J. H., Frederix, Geert W. J., Molenaar, I. Quintus, Welsing, Paco M. J., Moons, Leon M. G., van Santvoort, Hjalmar C., and Vleggaar, Frank P.

Published
2023
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4. A mixed-methods study to define Textbook Outcome for the treatment of patients with uncomplicated symptomatic gallstone disease with hospital variation analyses in Dutch trial data

Author

Eijsbouts, Quirijn A.J., Heisterkamp, Joos, Boerma, Djamila, Jennifer, M.J., van Duivendijk, Peter, Wiering, Bastiaan, Boermeester, Marja A., Diepenhorst, Gwen, van der Bilt, Jarmila, Buyne, Otmar, Venneman, Niels G., Keszthelyi, Daniel, Ahmed, Ifran, Hugh, Thomas J., Wigmore, Stephen J., Strasberg, Steven M., Harrison, Ewen M., Lammert, Frank, Gurusamy, Kurinchi, Moris, Dimitros, Soreide, Kjetil, Pappas, Theodore N., Kapoor, Vinay K., Speelman, Antonia, van den Brink, Chris, Thunnissen, Floris M., Comes, Daan J., Latenstein, Carmen S.S., Stommel, Martijn W.J., van Laarhoven, Cornelis J.H.M., Drenth, Joost P.H., Lantinga, Marten A., Atsma, Femke, and de Reuver, Philip R.

Published
2023
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5. Overuse and Misuse of Antibiotics and the Clinical Consequence in Necrotizing Pancreatitis: An Observational Multicenter Study

Author

Timmerhuis, Hester C., van den Berg, Fons F., Noorda, Paula C., van Dijk, Sven M., van Grinsven, Janneke, Sperna Weiland, Christina J., Umans, Devica S., Mohamed, Yasmin A., Curvers, Wouter L., Bouwense, Stefan A.W., Hadithi, Muhammed, Inderson, Akin, Issa, Yama, Jansen, Jeroen M., de Jonge, Pieter Jan F., Quispel, Rutger, Schwartz, Matthijs P., Stommel, Martijn W.J., Tan, Adriaan C.I.T.L., Venneman, Niels G., Besselink, Marc G., Bruno, Marco J., Bollen, Thomas L., Sieswerda, Elske, Verdonk, Robert C., Voermans, Rogier P., and van Santvoort, Hjalmar C.

Published
2023
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6. Diagnostic accuracy of endoscopic ultrasonography-guided tissue acquisition prior to resection of pancreatic carcinoma: a nationwide analysis

Author

Quispel, Rutger, Schutz, Hannah M., Keultjes, Augustinus W.P., Erler, Nicole S., Janssen, Quisette P., van Hooft, Jeanin E., Venneman, Niels G., Honkoop, Pieter, Hol, Lieke, Scheffer, Robert C., Bisseling, Tanya M., Voermans, Rogier P., Vleggaar, Frank P., Schwartz, Matthijs P., Verdonk, Robert C., Hoge, Chantal V., Kuiken, Sjoerd D., Curvers, Wouter L., van Vilsteren, Frederike G.I., Poen, Alexander C., Spanier, Marcel B., Bruggink, Annette H., Smedts, Frank M., van Velthuysen, Marie-Louise F., van Eijck, Casper H., Besselink, Marc G., Veldt, Bart J., Koerkamp, Bas G., van Driel, Lydi M.J.W., and Bruno, Marco J.

Published
2023
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7. Aggressive fluid hydration plus non-steroidal anti-inflammatory drugs versus non-steroidal anti-inflammatory drugs alone for post-endoscopic retrograde cholangiopancreatography pancreatitis (FLUYT): a multicentre, open-label, randomised, controlled trial

Author

Sperna Weiland, Christina J, Smeets, Xavier J N M, Kievit, Wietske, Verdonk, Robert C, Poen, Alexander C, Bhalla, Abha, Venneman, Niels G, Witteman, Ben J M, da Costa, David W, van Eijck, Brechje C, Schwartz, Matthijs P, Römkens, Tessa E H, Vrolijk, Jan Maarten, Hadithi, Muhammed, Voorburg, Annet M C J, Baak, Lubbertus C, Thijs, Willem J, van Wanrooij, Roy L, Tan, Adriaan C I T L, Seerden, Tom C J, Keulemans, Yolande C A, de Wijkerslooth, Thomas R, van de Vrie, Wim, van der Schaar, Peter, van Dijk, Sven M, Hallensleben, Nora D L, Sperna Weiland, Ruud L, Timmerhuis, Hester C, Umans, Devica S, van Hooft, Jeanin E, van Goor, Harry, van Santvoort, Hjalmar C, Besselink, Marc G, Bruno, Marco J, Fockens, Paul, Drenth, Joost P H, and van Geenen, Erwin J M

Published
2021
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8. Nationwide practice and outcomes of endoscopic biliary drainage in resectable pancreatic head and periampullary cancer

Author

Latenstein, Anouk E.J., Mackay, Tara M., van Huijgevoort, Nadine C.M., Bonsing, Bert A., Bosscha, Koop, Hol, Lieke, Bruno, Marco J., van Coolsen, Marielle M.E., Festen, Sebastiaan, van Geenen, Erwin, Groot Koerkamp, Bas, Hemmink, Gerrit J.M., de Hingh, Ignace H.J.T., Kazemier, Geert, Lubbinge, Hans, de Meijer, Vincent E., Molenaar, I. Quintus, Quispel, Rutger, van Santvoort, Hjalmar C., Seerden, Tom C.J., Stommel, Martijn W.J., Venneman, Niels G., Verdonk, Robert C., Besselink, Marc G., and van Hooft, Jeanin E.

Published
2021
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9. Long-term follow-up study of necrotising pancreatitis: interventions, complications and quality of life

Author

Hollemans, Robbert A, primary, Timmerhuis, Hester C, additional, Besselink, Marc G, additional, Bouwense, Stefan A W, additional, Bruno, Marco, additional, van Duijvendijk, Peter, additional, van Geenen, Erwin-Jan, additional, Hadithi, Muhammed, additional, Hofker, Sybrand, additional, Van-Hooft, Jeanin E, additional, Kager, Liesbeth M, additional, Manusama, Eric R, additional, Poley, Jan-Werner, additional, Quispel, Rutger, additional, Römkens, Tessa, additional, van der Schelling, George P, additional, Schwartz, Matthijs P, additional, Spanier, Bernhard W M, additional, Stommel, Martijn, additional, Tan, Adriaan, additional, Venneman, Niels G, additional, Vleggaar, Frank, additional, van Wanrooij, Roy L J, additional, Bollen, Thomas L, additional, Voermans, Rogier P, additional, Verdonk, Robert C, additional, and van Santvoort, Hjalmar C, additional

Published
2024
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10. Impact of nationwide implementation of best practices in pancreatic cancer care (PACAP-1): a stepped-wedge cluster randomised controlled trial

Author

Augustinus, Simone, primary, Mackay, Tara M., additional, Latenstein, Anouk E.J., additional, van der Geest, Lydia G., additional, Bogte, Auke, additional, Bonsing, Bert A., additional, Bos, Hendrik, additional, Bosscha, Koop, additional, Borsens, Lodewijk A.A., additional, Cirkel, Geert A., additional, Hol, Lieke, additional, Busch, Olivier R.C., additional, Creemers, Geert-Jan, additional, Curvers, Wouter L., additional, Derks, Sarah, additional, Dulk, Marcel den, additional, van Dieren, Susan, additional, van Driel, Lydi M.J.W., additional, Festen, Sebastiaan, additional, van Geenen, Erwin J.M., additional, de Groot, Derk-Jan A., additional, de Groot, Jan-Willem B., additional, Koerkamp, Bas Groot, additional, Mohammad, Nadia Haj, additional, Haberkorn, Brigitte C.M., additional, Haver, Joyce T., additional, van der Harst, Erwin, additional, Hemmink, G.J. Maarten, additional, de Hingh, Ignace H., additional, Hoge, Chantal, additional, Homs, Marjolein Y.V., additional, Inderson, Akin, additional, Jacobs, Maarten A.J.M., additional, Kerver, Emile D., additional, Liem, Mike S.L., additional, Los, Maartje, additional, Lubbinge, Hans, additional, Luelmo, Saskia A.C., additional, de Meijer, Vincent E., additional, Mekenkamp, Leonie, additional, Molenaar, I. Quintus, additional, Patijn, Gijs A., additional, Quispel, Rutger, additional, Römkens, Tessa E.H., additional, van Santvoort, Hjalmar C., additional, Schreinemakers, Jennifer M.J., additional, Schut, Heidi, additional, Seerden, Tom, additional, Stommel, Martijn W.J., additional, Venneman, Niels G., additional, Verdonk, Robert C., additional, Verheij, Joanne, additional, van Vilsteren, Frederike G.I., additional, de Vos-Geelen, Judith, additional, Vulink, Annelie, additional, Wientjes, Caroline A., additional, Wit, Fennie, additional, Wessels, Frank J., additional, Zonderhuis, Babs, additional, Henri van Werkhoven, C., additional, van Hooft, Jeanin E., additional, van Eijck, Casper H.J., additional, Wilmink, Johanna W., additional, van Laarhoven, Hanneke W.M., additional, and Besselink, Marc G., additional

Published
2023
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11. Corrigendum to ‘A mixed-methods study to define Textbook Outcome for the treatment of patients with uncomplicated symptomatic gallstone disease with hospital variation analyses in Dutch trial data’ [Volume 25, Issue 9, September 2023, Pages 1000–1010]

Author

Thunnissen, Floris M., primary, Comes, Daan J., additional, Latenstein, Carmen S.S., additional, Stommel, Martijn W.J., additional, van Laarhoven, Cornelis J.H.M., additional, Drenth, Joost P.H., additional, Lantinga, Marten A., additional, Atsma, Femke, additional, de Reuver, Philip R., additional, Eijsbouts, Quirijn A.J., additional, Heisterkamp, Joos, additional, Boerma, Djamila, additional, Jennifer, M.J., additional, van Duivendijk, Peter, additional, Wiering, Bastiaan, additional, Boermeester, Marja A., additional, Diepenhorst, Gwen, additional, van der Bilt, Jarmila, additional, Buyne, Otmar, additional, Venneman, Niels G., additional, Keszthelyi, Daniel, additional, Ahmed, Ifran, additional, Hugh, Thomas J., additional, Wigmore, Stephen J., additional, Strasberg, Steven M., additional, Harrison, Ewen M., additional, Lammert, Frank, additional, Gurusamy, Kurinchi, additional, Moris, Dimitros, additional, Soreide, Kjetil, additional, Pappas, Theodore N., additional, Kapoor, Vinay K., additional, Speelman, Antonia, additional, and van den Brink, Chris, additional

Published
2023
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12. Prospective multicentre study of indications for surgery in patients with idiopathic acute pancreatitis following endoscopic ultrasonography (PICUS)

Author

Umans, Devica S, primary, Timmerhuis, Hester C, additional, Anten, Marie-Paule G F, additional, Bhalla, Abha, additional, Bijlsma, Rina A, additional, Boxhoorn, Lotte, additional, Brink, Menno A, additional, Bruno, Marco J, additional, Curvers, Wouter L, additional, van Eijck, Brechje C, additional, Erkelens, G Willemien, additional, van Geenen, Erwin J M, additional, Hazen, Wouter L, additional, Hoge, Chantal V, additional, Hol, Lieke, additional, Inderson, Akin, additional, Kager, Liesbeth M, additional, Kuiken, Sjoerd D, additional, Perk, Lars E, additional, Quispel, Rutger, additional, Römkens, Tessa E H, additional, Sperna Weiland, Christina J, additional, Thijssen, Annemieke Y, additional, Venneman, Niels G, additional, Verdonk, Robert C, additional, van Wanrooij, Roy L J, additional, Witteman, Ben J, additional, Besselink, Marc G, additional, and van Hooft, Jeanin E, additional

Published
2023
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13. Endoscopic or surgical step-up approach for infected necrotising pancreatitis: a multicentre randomised trial

Author

Manusama, Eric R, Hadithi, Mohammed, Rosman, Camiel, Schaapherder, Alexander F, Schoon, Erik J, van Brunschot, Sandra, van Grinsven, Janneke, van Santvoort, Hjalmar C, Bakker, Olaf J, Besselink, Marc G, Boermeester, Marja A, Bollen, Thomas L, Bosscha, Koop, Bouwense, Stefan A, Bruno, Marco J, Cappendijk, Vincent C, Consten, Esther C, Dejong, Cornelis H, van Eijck, Casper H, Erkelens, Willemien G, van Goor, Harry, van Grevenstein, Wilhelmina M U, Haveman, Jan-Willem, Hofker, Sijbrand H, Jansen, Jeroen M, Laméris, Johan S, van Lienden, Krijn P, Meijssen, Maarten A, Mulder, Chris J, Nieuwenhuijs, Vincent B, Poley, Jan-Werner, Quispel, Rutger, de Ridder, Rogier J, Römkens, Tessa E, Scheepers, Joris J, Schepers, Nicolien J, Schwartz, Matthijs P, Seerden, Tom, Spanier, B W Marcel, Straathof, Jan Willem A, Strijker, Marin, Timmer, Robin, Venneman, Niels G, Vleggaar, Frank P, Voermans, Rogier P, Witteman, Ben J, Gooszen, Hein G, Dijkgraaf, Marcel G, and Fockens, Paul

Published
2018
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14. A mixed-methods study to define Textbook Outcome for the treatment of patients with uncomplicated symptomatic gallstone disease with hospital variation analyses in Dutch trial data

Author

Thunnissen, Floris M., primary, Comes, Daan J., additional, Latenstein, Carmen S.S., additional, Stommel, Martijn W.J., additional, van Laarhoven, Cornelis J.H.M., additional, Drenth, Joost P.H., additional, Lantinga, Marten A., additional, Atsma, Femke, additional, de Reuver, Philip R., additional, Eijsbouts, Quirijn A.J., additional, Heisterkamp, Joos, additional, Boerma, Djamila, additional, Jennifer, M.J., additional, van Duivendijk, Peter, additional, Wiering, Bastiaan, additional, Boermeester, Marja A., additional, Diepenhorst, Gwen, additional, van der Bilt, Jarmila, additional, Buyne, Otmar, additional, Venneman, Niels G., additional, Keszthelyi, Daniel, additional, Ahmed, Ifran, additional, Hugh, Thomas J., additional, Wigmore, Stephen J., additional, Strasberg, Steven M., additional, Harrison, Ewen M., additional, Lammert, Frank, additional, Gurusamy, Kurinchi, additional, Moris, Dimitros, additional, Soreide, Kjetil, additional, Pappas, Theodore N., additional, Kapoor, Vinay K., additional, Speelman, Antonia, additional, and van den Brink, Chris, additional

Published
2023
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15. Implementation of Best Practices in Pancreatic Cancer Care in the Netherlands: A Stepped-Wedge Randomized Clinical Trial

Author

Mackay, Tara M., Latenstein, Anouk E. J., Augustinus, Simone, van der Geest, Lydia G., Bogte, Auke, Bonsing, Bert A., Cirkel, Geert A., Hol, Lieke, Busch, Olivier R., den Dulk, Marcel, van Driel, Lydi M. J.W., Festen, Sebastiaan, de Groot, Derk-Jan A., de Groot, Jan-Willem B., Groot Koerkamp, Bas, Haj Mohammad, Nadia, Haver, Joyce T., van der Harst, Erwin, de Hingh, Ignace H., Homs, Marjolein Y. V., Los, Maartje, Luelmo, Saskia A. C., de Meijer, Vincent E., Mekenkamp, Leonie, Molenaar, I. Quintus, Patijn, Gijs A., Quispel, Rutger, Römkens, Tessa E. H., van Santvoort, Hjalmar C., Stommel, Martijn W.J., Venneman, Niels G., Verdonk, Robert C., van Vilsteren, Frederike G. I., de Vos-Geelen, Judith, van Werkhoven, C. Henri, van Hooft, Jeanin E., van Eijck, Casper H. J., Wilmink, Johanna W., van Laarhoven, Hanneke W. M., and Besselink, Marc G.

Abstract

IMPORTANCE: Implementation of new cancer treatment strategies as recommended by evidence-based guidelines is often slow and suboptimal. OBJECTIVE: To improve the implementation of guideline-based best practices in the Netherlands in pancreatic cancer care and assess the impact on survival. DESIGN, SETTING, AND PARTICIPANTS: This multicenter, stepped-wedge cluster randomized trial compared enhanced implementation of best practices with usual care in consecutive patients with all stages of pancreatic cancer. It took place from May 22, 2018 through July 9, 2020. Data were analyzed from April 1, 2022, through February 1, 2023. It included all patients in the Netherlands with pathologically or clinically diagnosed pancreatic ductal adenocarcinoma. This study reports 1-year follow-up (or shorter in case of deceased patients). INTERVENTION: The 5 best practices included optimal use of perioperative chemotherapy, palliative chemotherapy, pancreatic enzyme replacement therapy (PERT), referral to a dietician, and use of metal stents in patients with biliary obstruction. A 6-week implementation period was completed, in a randomized order, in all 17 Dutch networks for pancreatic cancer care. MAIN OUTCOMES AND MEASURES: The primary outcome was 1-year survival. Secondary outcomes included adherence to best practices and quality of life (European Organisation for Research and Treatment of Cancer [EORTC] global health score). RESULTS: Overall, 5887 patients with pancreatic cancer (median age, 72.0 [IQR, 64.0-79.0] years; 50% female) were enrolled, 2641 before and 2939 after implementation of best practices (307 during wash-in period). One-year survival was 24% vs 23% (hazard ratio, 0.98, 95% CI, 0.88-1.08). There was no difference in the use of neoadjuvant chemotherapy (11% vs 11%), adjuvant chemotherapy (48% vs 51%), and referral to a dietician (59% vs 63%), while the use of palliative chemotherapy (24% vs 30%; odds ratio [OR], 1.38; 95% CI, 1.10-1.74), PERT (34% vs 45%; OR, 1.64; 95% CI, 1.28-2.11), and metal biliary stents increased (74% vs 83%; OR, 1.78; 95% CI, 1.13-2.80). The EORTC global health score did not improve (area under the curve, 43.9 vs 42.8; median difference, −1.09, 95% CI, −3.05 to 0.94). CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, implementation of 5 best practices in pancreatic cancer care did not improve 1-year survival and quality of life. The finding that most patients received no tumor-directed treatment paired with the poor survival highlights the need for more personalized treatment options. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03513705

Published
2024
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16. Endoscopic ultrasonography-guided gastroenterostomy versus surgical gastrojejunostomy for palliation of malignant gastric outlet obstruction (ENDURO): study protocol for a randomised controlled trial

Author

de Pavert, Yorick L. van, primary, Kastelijn, Janine B., additional, Besselink, Marc G., additional, Fockens, Paul, additional, Voermans, Rogier P., additional, Wanrooij, Roy L.J. van, additional, de Wijkerslooth, Thomas R., additional, Curvers, Wouter L., additional, de Hingh, Ignace H.J.T., additional, Bruno, Marco J., additional, Koerkamp, Bas Groot, additional, Patijn, Gijs A., additional, Poen, Alexander C., additional, Hooft, Jeanin E. van, additional, Inderson, Akin, additional, Mieog, J. Sven D., additional, Poley, Jan-Werner, additional, Bijlsma, Alderina, additional, Lips, Daan J., additional, Venneman, Niels G., additional, Verdonk, Robert C., additional, Dullemen, Hendrik M. van, additional, Hoogwater, Frederik J.H., additional, Frederix, Geert W.J., additional, Molenaar, I. Quintus, additional, Welsing, Paco M.J., additional, Moons, Leon M.G., additional, Santvoort, Hjalmar C. van, additional, and Vleggaar, Frank P., additional

Published
2023
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17. Short-term and Long-term Outcomes of a Disruption and Disconnection of the Pancreatic Duct in Necrotizing Pancreatitis: A Multicenter Cohort Study in 896 Patients

Author

Timmerhuis, Hester C, van Dijk, Sven M, Hollemans, Robbert A, Sperna Weiland, Christina J, Umans, Devica S, Boxhoorn, Lotte, Hallensleben, Nora H, van der Sluijs, Rogier, Brouwer, Lieke, van Duijvendijk, Peter, Kager, Liesbeth, Kuiken, Sjoerd, Poley, Jan-Werner, de Ridder, Rogier, Römkens, Tessa, Quispel, Rutger, Schwartz, Matthijs P, Tan, Adriaan C I T L, Venneman, Niels G, Vleggaar, Frank P, van Wanrooij, Roy L J, Witteman, Ben J, van Geenen, Erwin, Molenaar, I Quintus, Bruno, Marco J, van Hooft, Jeanin E, Besselink, Marc G, Voermans, Rogier P, Bollen, Thomas L, Verdonk, Robert C, van Santvoort, Hjalmar C, Dutch Pancreatitis Study Group, Timmerhuis, Hester C, van Dijk, Sven M, Hollemans, Robbert A, Sperna Weiland, Christina J, Umans, Devica S, Boxhoorn, Lotte, Hallensleben, Nora H, van der Sluijs, Rogier, Brouwer, Lieke, van Duijvendijk, Peter, Kager, Liesbeth, Kuiken, Sjoerd, Poley, Jan-Werner, de Ridder, Rogier, Römkens, Tessa, Quispel, Rutger, Schwartz, Matthijs P, Tan, Adriaan C I T L, Venneman, Niels G, Vleggaar, Frank P, van Wanrooij, Roy L J, Witteman, Ben J, van Geenen, Erwin, Molenaar, I Quintus, Bruno, Marco J, van Hooft, Jeanin E, Besselink, Marc G, Voermans, Rogier P, Bollen, Thomas L, Verdonk, Robert C, van Santvoort, Hjalmar C, and Dutch Pancreatitis Study Group

Abstract

INTRODUCTION:Necrotizing pancreatitis may result in a disrupted or disconnected pancreatic duct (DPD) with the potential for long-lasting negative impact on a patient's clinical outcome. There is a lack of detailed data on the full clinical spectrum of DPD, which is critical for the development of better diagnostic and treatment strategies.METHODS:We performed a long-term post hoc analysis of a prospectively collected nationwide cohort of 896 patients with necrotizing pancreatitis (2005-2015). The median follow-up after hospital admission was 75 months (P25-P75: 41-151). Clinical outcomes of patients with and without DPD were compared using regression analyses, adjusted for potential confounders. Predictive features for DPD were explored.RESULTS:DPD was confirmed in 243 (27%) of the 896 patients and resulted in worse clinical outcomes during both the patient's initial admission and follow-up. During hospital admission, DPD was associated with an increased rate of new-onset intensive care unit admission (adjusted odds ratio [aOR] 2.52; 95% confidence interval [CI] 1.62-3.93), new-onset organ failure (aOR 2.26; 95% CI 1.45-3.55), infected necrosis (aOR 4.63; 95% CI 2.87-7.64), and pancreatic interventions (aOR 7.55; 95% CI 4.23-13.96). During long-term follow-up, DPD increased the risk of pancreatic intervention (aOR 9.71; 95% CI 5.37-18.30), recurrent pancreatitis (aOR 2.08; 95% CI 1.32-3.29), chronic pancreatitis (aOR 2.73; 95% CI 1.47-5.15), and endocrine pancreatic insufficiency (aOR 1.63; 95% CI 1.05-2.53). Central or subtotal pancreatic necrosis on computed tomography (OR 9.49; 95% CI 6.31-14.29) and a high level of serum C-reactive protein in the first 48 hours after admission (per 10-point increase, OR 1.02; 95% CI 1.00-1.03) were identified as independent predictors for developing DPD.DISCUSSION:At least 1 of every 4 patients with necrotizing pancreatitis experience DPD, which is associated with detrimental, short-term and long-term interventions, and comp

Published
2023

18. Diagnostic accuracy of endoscopic ultrasonography-guided tissue acquisition prior to resection of pancreatic carcinoma:a nationwide analysis

Author

Quispel, Rutger, Schutz, Hannah M., Keultjes, Augustinus W.P., Erler, Nicole S., Janssen, Quisette P., van Hooft, Jeanin E., Venneman, Niels G., Honkoop, Pieter, Hol, Lieke, Scheffer, Robert C., Bisseling, Tanya M., Voermans, Rogier P., Vleggaar, Frank P., Schwartz, Matthijs P., Verdonk, Robert C., Hoge, Chantal V., Kuiken, Sjoerd D., Curvers, Wouter L., van Vilsteren, Frederike G.I., Poen, Alexander C., Spanier, Marcel B., Bruggink, Annette H., Smedts, Frank M., van Velthuysen, Marie Louise F., van Eijck, Casper H., Besselink, Marc G., Veldt, Bart J., Koerkamp, Bas G., van Driel, Lydi M.J.W., Bruno, Marco J., Quispel, Rutger, Schutz, Hannah M., Keultjes, Augustinus W.P., Erler, Nicole S., Janssen, Quisette P., van Hooft, Jeanin E., Venneman, Niels G., Honkoop, Pieter, Hol, Lieke, Scheffer, Robert C., Bisseling, Tanya M., Voermans, Rogier P., Vleggaar, Frank P., Schwartz, Matthijs P., Verdonk, Robert C., Hoge, Chantal V., Kuiken, Sjoerd D., Curvers, Wouter L., van Vilsteren, Frederike G.I., Poen, Alexander C., Spanier, Marcel B., Bruggink, Annette H., Smedts, Frank M., van Velthuysen, Marie Louise F., van Eijck, Casper H., Besselink, Marc G., Veldt, Bart J., Koerkamp, Bas G., van Driel, Lydi M.J.W., and Bruno, Marco J.

Abstract

Introduction: Endoscopic ultrasonography guided tissue acquisition (EUS + TA) is used to provide a tissue diagnosis in patients with suspected pancreatic cancer. Key performance indicators (KPI) for these procedures are rate of adequate sample (RAS) and sensitivity for malignancy (SFM). Aim: assess practice variation regarding KPI of EUS + TA prior to resection of pancreatic carcinoma in the Netherlands. Patients and methods: Results of all EUS + TA prior to resection of pancreatic carcinoma from 2014–2018, were extracted from the national Dutch Pathology Registry (PALGA). Pathology reports were classified as: insufficient for analysis (b1), benign (b2), atypia (b3), neoplastic other (b4), suspected malignant (b5), and malignant (b6). RAS was defined as the proportion of EUS procedures yielding specimen sufficient for analysis. SFM was calculated using a strict definition (malignant only, SFM-b6), and a broader definition (SFM-b5+6). Results: 691 out of 1638 resected patients (42%) underwent preoperative EUS + TA. RAS was 95% (range 89–100%), SFM-b6 was 44% (20–77%), and SFM-b5+6 was 65% (53–90%). All centers met the performance target RAS>85%. Only 9 out of 17 met the performance target SFM-b5+6 > 85%. Conclusion: This nationwide study detected significant practice variation regarding KPI of EUS + TA procedures prior to surgical resection of pancreatic carcinoma. Therefore, quality improvement of EUS + TA is indicated.

Published
2023

19. Endoscopic ultrasonography-guided gastroenterostomy versus surgical gastrojejunostomy for palliation of malignant gastric outlet obstruction (ENDURO):study protocol for a randomized controlled trial

Author

Kastelijn, Janine B., van de Pavert, Yorick L., Besselink, Marc G., Fockens, Paul, Voermans, Rogier P., van Wanrooij, Roy L.J., de Wijkerslooth, Thomas R., Curvers, Wouter L., de Hingh, Ignace H.J.T., Bruno, Marco J., Koerkamp, Bas Groot, Patijn, Gijs A., Poen, Alexander C., van Hooft, Jeanin E., Inderson, Akin, Mieog, J. Sven D., Poley, Jan Werner, Bijlsma, Alderina, Lips, Daan J., Venneman, Niels G., Verdonk, Robert C., van Dullemen, Hendrik M., Hoogwater, Frederik J.H., Frederix, Geert W.J., Molenaar, I. Quintus, Welsing, Paco M.J., Moons, Leon M.G., van Santvoort, Hjalmar C., Vleggaar, Frank P., Kastelijn, Janine B., van de Pavert, Yorick L., Besselink, Marc G., Fockens, Paul, Voermans, Rogier P., van Wanrooij, Roy L.J., de Wijkerslooth, Thomas R., Curvers, Wouter L., de Hingh, Ignace H.J.T., Bruno, Marco J., Koerkamp, Bas Groot, Patijn, Gijs A., Poen, Alexander C., van Hooft, Jeanin E., Inderson, Akin, Mieog, J. Sven D., Poley, Jan Werner, Bijlsma, Alderina, Lips, Daan J., Venneman, Niels G., Verdonk, Robert C., van Dullemen, Hendrik M., Hoogwater, Frederik J.H., Frederix, Geert W.J., Molenaar, I. Quintus, Welsing, Paco M.J., Moons, Leon M.G., van Santvoort, Hjalmar C., and Vleggaar, Frank P.

Abstract

Background: Malignant gastric outlet obstruction (GOO) is a debilitating condition that frequently occurs in patients with malignancies of the distal stomach and (peri)ampullary region. The standard palliative treatment for patients with a reasonable life expectancy and adequate performance status is a laparoscopic surgical gastrojejunostomy (SGJ). Recently, endoscopic ultrasound-guided gastroenterostomy (EUS-GE) emerged as a promising alternative to the surgical approach. The present study aims to compare these treatment modalities in terms of efficacy, safety, and costs. Methods: The ENDURO-study is a multicentre, open-label, parallel-group randomized controlled trial. In total, ninety-six patients with gastric outlet obstruction caused by an irresectable or metastasized malignancy will be 1:1 randomized to either SGJ or EUS-GE. The primary endpoint is time to tolerate at least soft solids. The co-primary endpoint is the proportion of patients with persisting or recurring symptoms of gastric outlet obstruction for which a reintervention is required. Secondary endpoints are technical and clinical success, quality of life, gastroenterostomy dysfunction, reinterventions, time to reintervention, adverse events, quality of life, time to start chemotherapy, length of hospital stay, readmissions, weight, survival, and costs. Discussion: The ENDURO-study assesses whether EUS-GE, as compared to SGJ, results in a faster resumption of solid oral intake and is non-inferior regarding reinterventions for persistent or recurrent obstructive symptoms in patients with malignant GOO. This trial aims to guide future treatment strategies and to improve quality of life in a palliative setting. Trial registration: International Clinical Trials Registry Platform (ICTRP): NL9592. Registered on 07 July 2021.

Published
2023

20. Suspected common bile duct stones:reduction of unnecessary ERCP by pre-procedural imaging and timing of ERCP

Author

Weiland, Christina J. Sperna, Verschoor, Evelien C., Poen, Alexander C., Smeets, Xavier J. M. N., Venneman, Niels G., Bhalla, Abha, Witteman, Ben J. M., Timmerhuis, Hester C., Umans, Devica S., van Hooft, Jeanin E., Bruno, Marco J., Fockens, P., Verdonk, Robert C., Drenth, Joost P. H., van Geenen, Erwin J. M., Weiland, Christina J. Sperna, Verschoor, Evelien C., Poen, Alexander C., Smeets, Xavier J. M. N., Venneman, Niels G., Bhalla, Abha, Witteman, Ben J. M., Timmerhuis, Hester C., Umans, Devica S., van Hooft, Jeanin E., Bruno, Marco J., Fockens, P., Verdonk, Robert C., Drenth, Joost P. H., and van Geenen, Erwin J. M.

Abstract

Background: Endoscopic retrograde cholangiopancreatography (ERCP) is the procedure of choice to remove sludge/stones from the common bile duct (CBD). In a small but clinically important proportion of patients with suspected choledocholithiasis ERCP is negative. This is undesirable because of ERCP associated morbidity. We aimed to map the diagnostic pathway leading up to ERCP and evaluate ERCP outcome. Methods: We established a prospective multicenter cohort of patients with suspected CBD stones. We assessed the determinants that were associated with CBD sludge or stone detection upon ERCP. Results: We established a cohort of 707 patients with suspected CBD sludge or stones (62% female, median age 59 years). ERCP was negative for CBD sludge or stones in 155 patients (22%). Patients with positive ERCPs frequently had pre-procedural endoscopic ultrasonography (EUS) or magnetic resonance cholangiopancreatography (MRCP) imaging (44% vs. 35%; P = 0.045). The likelihood of ERCP sludge and stones detection was higher when the time interval between EUS or MRCP and ERCP was less than 2 days (odds ratio 2.35; 95% CI 1.25–4.44; P = 0.008; number needed to harm 7.7). Conclusions: Even in the current era of society guidelines and use of advanced imaging CBD sludge or stones are absent in one out of five ERCPs performed for suspected CBD stones. The proportion of unnecessary ERCPs is lower in case of pre-procedural EUS or MRCP. A shorter time interval between EUS or MRCP increases the yield of ERCP for suspected CBD stones and should, therefore, preferably be performed within 2 days before ERCP. Graphical abstract: [Figure not available: see fulltext.].

Published
2023

21. Short-term and Long-term Outcomes of a Disruption and Disconnection of the Pancreatic Duct in Necrotizing Pancreatitis: A Multicenter Cohort Study in 896 Patients

Author

MS MDL 1, Cancer, MS CGO, Timmerhuis, Hester C., Van Dijk, Sven M., Hollemans, Robbert A., Sperna Weiland, Christina J., Umans, Devica S., Boxhoorn, Lotte, Hallensleben, Nora H., Van Der Sluijs, Rogier, Brouwer, Lieke, Van Duijvendijk, Peter, Kager, Liesbeth, Kuiken, Sjoerd, Poley, Jan Werner, De Ridder, Rogier, Römkens, Tessa E.H., Quispel, Rutger, Schwartz, Matthijs P., Tan, Adriaan C.I.T.L., Venneman, Niels G., Vleggaar, Frank P., Van Wanrooij, Roy L.J., Witteman, Ben J., Van Geenen, Erwin J., Molenaar, I. Quintus, Bruno, Marco J., Van Hooft, Jeanin E., Besselink, Marc G., Voermans, Rogier P., Bollen, Thomas L., Verdonk, Robert C., Van Santvoort, Hjalmar C., MS MDL 1, Cancer, MS CGO, Timmerhuis, Hester C., Van Dijk, Sven M., Hollemans, Robbert A., Sperna Weiland, Christina J., Umans, Devica S., Boxhoorn, Lotte, Hallensleben, Nora H., Van Der Sluijs, Rogier, Brouwer, Lieke, Van Duijvendijk, Peter, Kager, Liesbeth, Kuiken, Sjoerd, Poley, Jan Werner, De Ridder, Rogier, Römkens, Tessa E.H., Quispel, Rutger, Schwartz, Matthijs P., Tan, Adriaan C.I.T.L., Venneman, Niels G., Vleggaar, Frank P., Van Wanrooij, Roy L.J., Witteman, Ben J., Van Geenen, Erwin J., Molenaar, I. Quintus, Bruno, Marco J., Van Hooft, Jeanin E., Besselink, Marc G., Voermans, Rogier P., Bollen, Thomas L., Verdonk, Robert C., and Van Santvoort, Hjalmar C.

Published
2023

22. Short- and long-term outcomes of a disruption and disconnection of the pancreatic duct in necrotizing pancreatitis: a multicenter cohort study in 896 patients : Disrupted pancreatic duct in acute pancreatitis

Author

Timmerhuis, Hester C, van Dijk, Sven M, Hollemans, Robbert A, Sperna Weiland, Christina J, Umans, Devica S, Boxhoorn, Lotte, Hallensleben, Nora H, van der Sluijs, Rogier, Brouwer, Lieke, van Duijvendijk, Peter, Kager, Liesbeth, Kuiken, Sjoerd, Poley, Jan-Werner, de Ridder, Rogier, Römkens, Tessa, Quispel, Rutger, Schwartz, Matthijs P, Tan, Adriaan C I T L, Venneman, Niels G, Vleggaar, Frank P, van Wanrooij, Roy L J, Witteman, Ben J, van Geenen, Erwin, Molenaar, I Quintus, Bruno, Marco J, van Hooft, Jeanin E, Besselink, Marc G, Voermans, Rogier P, Bollen, Thomas L, Verdonk, Robert C, van Santvoort, Hjalmar C, RS: FHML non-thematic output, MUMC+: MA Maag Darm Lever (9), and Interne Geneeskunde

Abstract

INTRODUCTION:Necrotizing pancreatitis may result in a disrupted or disconnected pancreatic duct (DPD) with the potential for long-lasting negative impact on a patient's clinical outcome. There is a lack of detailed data on the full clinical spectrum of DPD, which is critical for the development of better diagnostic and treatment strategies.METHODS:We performed a long-term post hoc analysis of a prospectively collected nationwide cohort of 896 patients with necrotizing pancreatitis (2005-2015). The median follow-up after hospital admission was 75 months (P25-P75: 41-151). Clinical outcomes of patients with and without DPD were compared using regression analyses, adjusted for potential confounders. Predictive features for DPD were explored.RESULTS:DPD was confirmed in 243 (27%) of the 896 patients and resulted in worse clinical outcomes during both the patient's initial admission and follow-up. During hospital admission, DPD was associated with an increased rate of new-onset intensive care unit admission (adjusted odds ratio [aOR] 2.52; 95% confidence interval [CI] 1.62-3.93), new-onset organ failure (aOR 2.26; 95% CI 1.45-3.55), infected necrosis (aOR 4.63; 95% CI 2.87-7.64), and pancreatic interventions (aOR 7.55; 95% CI 4.23-13.96). During long-term follow-up, DPD increased the risk of pancreatic intervention (aOR 9.71; 95% CI 5.37-18.30), recurrent pancreatitis (aOR 2.08; 95% CI 1.32-3.29), chronic pancreatitis (aOR 2.73; 95% CI 1.47-5.15), and endocrine pancreatic insufficiency (aOR 1.63; 95% CI 1.05-2.53). Central or subtotal pancreatic necrosis on computed tomography (OR 9.49; 95% CI 6.31-14.29) and a high level of serum C-reactive protein in the first 48 hours after admission (per 10-point increase, OR 1.02; 95% CI 1.00-1.03) were identified as independent predictors for developing DPD.DISCUSSION:At least 1 of every 4 patients with necrotizing pancreatitis experience DPD, which is associated with detrimental, short-term and long-term interventions, and complications. Central and subtotal pancreatic necrosis and high levels of serum C-reactive protein in the first 48 hours are independent predictors for DPD.

Published
2023

23. Patient selection for urgent endoscopic retrograde cholangio-pancreatography by endoscopic ultrasound in predicted severe acute biliary pancreatitis (APEC-2): a multicentre prospective study

Author

Hallensleben, Nora D, primary, Stassen, Pauline M C, additional, Schepers, Nicolien J, additional, Besselink, Marc G, additional, Anten, Marie-Paule G F, additional, Bakker, Olaf J, additional, Bollen, Thomas L, additional, da Costa, David W, additional, van Dijk, Sven M, additional, van Dullemen, Hendrik M, additional, Dijkgraaf, Marcel G W, additional, van Eijck, Brechje, additional, van Eijck, Casper H J, additional, Erkelens, Willemien, additional, Erler, Nicole S, additional, Fockens, Paul, additional, van Geenen, Erwin-Jan M, additional, van Grinsven, Janneke, additional, Hazen, Wouter L, additional, Hollemans, Robbert A, additional, van Hooft, Jeanin E, additional, Jansen, Jeroen M, additional, Kubben, Frank J G M, additional, Kuiken, Sjoerd D, additional, Poen, Alexander C, additional, Quispel, Rutger, additional, de Ridder, Rogier J, additional, Römkens, Tessa E H, additional, Schoon, Erik J, additional, Schwartz, Matthijs P, additional, Seerden, Tom C J, additional, Smeets, Xavier J N M, additional, Spanier, B W Marcel, additional, Tan, Adriaan C I T L, additional, Thijs, Willem J, additional, Timmer, Robin, additional, Umans, Devica S, additional, Venneman, Niels G, additional, Verdonk, Robert C, additional, Vleggaar, Frank P, additional, van de Vrie, Wim, additional, van Wanrooij, Roy L J, additional, Witteman, Ben J, additional, van Santvoort, Hjalmar C, additional, Bouwense, Stefan A W, additional, and Bruno, Marco J, additional

Published
2023
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24. Immediate versus postponed intervention for infected necrotizing pancreatitis

Author

Boxhoorn, Lotte, van Dijk, Sven M., van Grinsven, Janneke, Verdonk, Robert C., Boermeester, Marja A., Bollen, Thomas L., Bouwense, Stefan A. W., Bruno, Marco J., Cappendijk, Vincent C., Dejong, Cornelis H. C., van Duijvendijk, Peter, van Eijck, Casper H. J., Fockens, Paul, Francken, Michiel F. G., van Goor, Harry, Hadithi, Muhammed, Hallensleben, Nora D. L., Haveman, Jan Willem, Jacobs, Maarten A. J. M., Jansen, Jeroen M., Kop, Marnix P. M., van Lienden, Krijn P., Manusama, Eric R., Mieog, Sven J. D., Molenaar, I. Quintus, Nieuwenhuijs, Vincent B., Poen, Alexander C., Poley, Jan-Werner, van de Poll, Marcel, Quispel, Rutger, Römkens, Tessa E. H., Schwartz, Matthijs P., Seerden, Tom C., Stommel, Martijn W. J., Straathof, Jan Willem A., Timmerhuis, Hester C., Venneman, Niels G., Voermans, Rogier P., van de Vrie, Wim, Witteman, Ben J., Dijkgraaf, Marcel G. W., van Santvoort, Hjalmar C., Besselink, Marc G., Study group members AMC, Stoker, Jaap, Gastroenterology & Hepatology, Surgery, Gastroenterology and Hepatology, Graduate School, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Radiology and Nuclear Medicine, Epidemiology and Data Science, APH - Methodology, MUMC+: MA Heelkunde (9), RS: NUTRIM - R2 - Liver and digestive health, Intensive Care, and MUMC+: MA Medische Staf IC (9)

Subjects
medicine.medical_specialty, MEDLINE, Disease, CLASSIFICATION, law.invention, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], Randomized controlled trial, law, Intervention (counseling), Catheter drainage, MANAGEMENT, Medicine, Combined Modality Therapy, STEP-UP APPROACH, OUTCOMES, business.industry, NECROSIS, General Medicine, NECROSECTOMY, medicine.disease, digestive system diseases, Surgery, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], Pancreatitis, business, Necrotizing pancreatitis
Abstract

Item does not contain fulltext BACKGROUND: Infected necrotizing pancreatitis is a potentially lethal disease that is treated with the use of a step-up approach, with catheter drainage often delayed until the infected necrosis is encapsulated. Whether outcomes could be improved by earlier catheter drainage is unknown. METHODS: We conducted a multicenter, randomized superiority trial involving patients with infected necrotizing pancreatitis, in which we compared immediate drainage within 24 hours after randomization once infected necrosis was diagnosed with drainage that was postponed until the stage of walled-off necrosis was reached. The primary end point was the score on the Comprehensive Complication Index, which incorporates all complications over the course of 6 months of follow-up. RESULTS: A total of 104 patients were randomly assigned to immediate drainage (55 patients) or postponed drainage (49 patients). The mean score on the Comprehensive Complication Index (scores range from 0 to 100, with higher scores indicating more severe complications) was 57 in the immediate-drainage group and 58 in the postponed-drainage group (mean difference, -1; 95% confidence interval [CI], -12 to 10; P = 0.90). Mortality was 13% in the immediate-drainage group and 10% in the postponed-drainage group (relative risk, 1.25; 95% CI, 0.42 to 3.68). The mean number of interventions (catheter drainage and necrosectomy) was 4.4 in the immediate-drainage group and 2.6 in the postponed-drainage group (mean difference, 1.8; 95% CI, 0.6 to 3.0). In the postponed-drainage group, 19 patients (39%) were treated conservatively with antibiotics and did not require drainage; 17 of these patients survived. The incidence of adverse events was similar in the two groups. CONCLUSIONS: This trial did not show the superiority of immediate drainage over postponed drainage with regard to complications in patients with infected necrotizing pancreatitis. Patients randomly assigned to the postponed-drainage strategy received fewer invasive interventions. (Funded by Fonds NutsOhra and Amsterdam UMC; POINTER ISRCTN Registry number, ISRCTN33682933.).

Published
2021

26. Fluid hydration to prevent post-ERCP pancreatitis in average- to high-risk patients receiving prophylactic rectal NSAIDs (FLUYT trial): study protocol for a randomized controlled trial

Author

Smeets, Xavier J. N. M., da Costa, David W., Fockens, Paul, Mulder, Chris J. J., Timmer, Robin, Kievit, Wietske, Zegers, Marieke, Bruno, Marco J., Besselink, Marc G. H., Vleggaar, Frank P., van der Hulst, Rene W. M., Poen, Alexander C., Heine, Gerbrand D. N., Venneman, Niels G., Kolkman, Jeroen J., Baak, Lubbertus C., Römkens, Tessa E. H., van Dijk, Sven M., Hallensleben, Nora D. L., van de Vrie, Wim, Seerden, Tom C. J., Tan, Adriaan C. I. T. L., Voorburg, Annet M. C. J., Poley, Jan-Werner, Witteman, Ben J., Bhalla, Abha, Hadithi, Muhammed, Thijs, Willem J., Schwartz, Matthijs P., Vrolijk, Jan Maarten, Verdonk, Robert C., van Delft, Foke, Keulemans, Yolande, van Goor, Harry, Drenth, Joost P. H., van Geenen, Erwin J. M., and for the Dutch Pancreatitis Study Group

Published
2018
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27. Endoscopic Versus Surgical Step-Up Approach for Infected Necrotizing Pancreatitis (ExTENSION): Long-term Follow-up of a Randomized Trial

Author

Onnekink, Anke M., primary, Boxhoorn, Lotte, additional, Timmerhuis, Hester C., additional, Bac, Simon T., additional, Besselink, Marc G., additional, Boermeester, Marja A., additional, Bollen, Thomas L., additional, Bosscha, Koop, additional, Bouwense, Stefan A.W., additional, Bruno, Marco J., additional, van Brunschot, Sandra, additional, Cappendijk, Vincent C., additional, Consten, Esther C.J., additional, Dejong, Cornelis H., additional, Dijkgraaf, Marcel G.W., additional, van Eijck, Casper H.J., additional, Erkelens, Willemien G., additional, van Goor, Harry, additional, van Grinsven, Janneke, additional, Haveman, Jan-Willem, additional, van Hooft, Jeanin E., additional, Jansen, Jeroen M., additional, van Lienden, Krijn P., additional, Meijssen, Maarten A.C., additional, Nieuwenhuijs, Vincent B., additional, Poley, Jan-Werner, additional, Quispel, Rutger, additional, de Ridder, Rogier J., additional, Römkens, Tessa E.H., additional, van Santvoort, Hjalmar C., additional, Scheepers, Joris J., additional, Schwartz, Matthijs P., additional, Seerden, Tom, additional, Spanier, Marcel B.W., additional, Straathof, Jan Willem A., additional, Timmer, Robin, additional, Venneman, Niels G., additional, Verdonk, Robert C., additional, Vleggaar, Frank P., additional, van Wanrooij, Roy L., additional, Witteman, Ben J.M., additional, Fockens, Paul, additional, and Voermans, Rogier P., additional

Published
2022
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28. Endoscopic Versus Surgical Step-Up Approach for Infected Necrotizing Pancreatitis (ExTENSION):Long-term Follow-up of a Randomized Trial

Author

Onnekink, Anke M., Boxhoorn, Lotte, Timmerhuis, Hester C., Bac, Simon T., Besselink, Marc G., Boermeester, Marja A., Bollen, Thomas L., Bosscha, Koop, Bouwense, Stefan A.W., Bruno, Marco J., van Brunschot, Sandra, Cappendijk, Vincent C., Consten, Esther C.J., Dejong, Cornelis H., Dijkgraaf, Marcel G.W., van Eijck, Casper H.J., Erkelens, Willemien G., van Goor, Harry, van Grinsven, Janneke, Haveman, Jan Willem, van Hooft, Jeanin E., Jansen, Jeroen M., van Lienden, Krijn P., Meijssen, Maarten A.C., Nieuwenhuijs, Vincent B., Poley, Jan Werner, Quispel, Rutger, de Ridder, Rogier J., Römkens, Tessa E.H., van Santvoort, Hjalmar C., Scheepers, Joris J., Schwartz, Matthijs P., Seerden, Tom, Spanier, Marcel B.W., Straathof, Jan Willem A., Timmer, Robin, Venneman, Niels G., Verdonk, Robert C., Vleggaar, Frank P., van Wanrooij, Roy L., Witteman, Ben J.M., Fockens, Paul, Voermans, Rogier P., Onnekink, Anke M., Boxhoorn, Lotte, Timmerhuis, Hester C., Bac, Simon T., Besselink, Marc G., Boermeester, Marja A., Bollen, Thomas L., Bosscha, Koop, Bouwense, Stefan A.W., Bruno, Marco J., van Brunschot, Sandra, Cappendijk, Vincent C., Consten, Esther C.J., Dejong, Cornelis H., Dijkgraaf, Marcel G.W., van Eijck, Casper H.J., Erkelens, Willemien G., van Goor, Harry, van Grinsven, Janneke, Haveman, Jan Willem, van Hooft, Jeanin E., Jansen, Jeroen M., van Lienden, Krijn P., Meijssen, Maarten A.C., Nieuwenhuijs, Vincent B., Poley, Jan Werner, Quispel, Rutger, de Ridder, Rogier J., Römkens, Tessa E.H., van Santvoort, Hjalmar C., Scheepers, Joris J., Schwartz, Matthijs P., Seerden, Tom, Spanier, Marcel B.W., Straathof, Jan Willem A., Timmer, Robin, Venneman, Niels G., Verdonk, Robert C., Vleggaar, Frank P., van Wanrooij, Roy L., Witteman, Ben J.M., Fockens, Paul, and Voermans, Rogier P.

Abstract

Background & Aims: Previous randomized trials, including the Transluminal Endoscopic Step-Up Approach Versus Minimally Invasive Surgical Step-Up Approach in Patients With Infected Pancreatic Necrosis (TENSION) trial, demonstrated that the endoscopic step-up approach might be preferred over the surgical step-up approach in patients with infected necrotizing pancreatitis based on favorable short-term outcomes. We compared long-term clinical outcomes of both step-up approaches after a period of at least 5 years. Methods: In this long-term follow-up study, we reevaluated all clinical data on 83 patients (of the originally 98 included patients) from the TENSION trial who were still alive after the initial 6-month follow-up. The primary end point, similar to the TENSION trial, was a composite of death and major complications. Secondary end points included individual major complications, pancreaticocutaneous fistula, reinterventions, pancreatic insufficiency, and quality of life. Results: After a mean follow-up period of 7 years, the primary end point occurred in 27 patients (53%) in the endoscopy group and in 27 patients (57%) in the surgery group (risk ratio [RR], 0.93; 95% confidence interval [CI], 0.65–1.32; P = .688). Fewer pancreaticocutaneous fistulas were identified in the endoscopy group (8% vs 34%; RR, 0.23; 95% CI, 0.08–0.83). After the initial 6-month follow-up, the endoscopy group needed fewer reinterventions than the surgery group (7% vs 24%; RR, 0.29; 95% CI, 0.09–0.99). Pancreatic insufficiency and quality of life did not differ between groups. Conclusions: At long-term follow-up, the endoscopic step-up approach was not superior to the surgical step-up approach in reducing death or major complications in patients with infected necrotizing pancreatitis. However, patients assigned to the endoscopic approach developed overall fewer pancreaticocutaneous fistulas and needed fewer reinterventions after the initial 6-month follow-up. Netherlands Tria

Published
2022

29. Performance of diagnostic tools for acute cholangitis in patients with suspected biliary obstruction

Author

Sperna Weiland, Christina J., Busch, Celine B.E., Bhalla, Abha, Bruno, Marco J., Fockens, Paul, van Hooft, Jeanin E., Poen, Alexander C., Timmerhuis, Hester C., Umans, Devica S., Venneman, Niels G., Verdonk, Robert C., Drenth, Joost P.H., de Wijkerslooth, Thomas R., van Geenen, Erwin J.M., Sperna Weiland, Christina J., Busch, Celine B.E., Bhalla, Abha, Bruno, Marco J., Fockens, Paul, van Hooft, Jeanin E., Poen, Alexander C., Timmerhuis, Hester C., Umans, Devica S., Venneman, Niels G., Verdonk, Robert C., Drenth, Joost P.H., de Wijkerslooth, Thomas R., and van Geenen, Erwin J.M.

Abstract

Background: Acute cholangitis is an infection requiring endoscopic retrograde cholangiopancreatography (ERCP) and antibiotics. Several diagnostic tools help to diagnose cholangitis. Because diagnostic performance of these tools has not been studied and might therefore impose unnecessary ERCPs, we aimed to evaluate this. Methods: We established a nationwide prospective cohort of patients with suspected biliary obstruction who underwent an ERCP. We assessed the diagnostic performance of Tokyo Guidelines (TG18), Dutch Pancreatitis Study Group (DPSG) criteria, and Charcot triad relative to real-world cholangitis as the reference standard. Results: 127 (16%) of 794 patients were diagnosed with real-world cholangitis. Using the TG18, DPSG, and Charcot triad, 345 (44%), 55 (7%), and 66 (8%) patients were defined as having cholangitis, respectively. Sensitivity for TG18 was 82% (95% CI 74-88) and specificity 60% (95% CI 56-63). The sensitivity for DPSG and Charcot was 42% (95% CI 33-51) and 46% (95% CI 38-56), specificity was 99.7% (95% CI 99-100) and 99% (95% CI 98-100), respectively. Conclusions: TG18 criteria incorrectly diagnoses four out of ten patients with real-world cholangitis, while DPSG and Charcot criteria failed to diagnose more than half of patients. As the cholangitis diagnosis has many consequences for treatment, there is a need for more accurate diagnostic tools or work-up towards ERCP.

Published
2022

30. Higher quality of life after metal stent placement compared with plastic stent placement for malignant extrahepatic bile duct obstruction: a randomized controlled trial

Author

Walter, Daisy, van Boeckel, Petra G.A., Groenen, Marcel J.M., Weusten, Bas L.A.M., Witteman, Ben J., Tan, Gi, Brink, Menno A., Nicolai, Jan, Tan, Adriaan C., Alderliesten, Joyce, Venneman, Niels G., Laleman, Wim, Jansen, Jeroen M., Bodelier, Alexander, Wolters, Frank L., van der Waaij, Laurens A., Breumelhof, Ronald, Peters, Frans T.M., Scheffer, Robbert C.H., Steyerberg, Ewout W., May, Anne M., Leenders, Max, Hirdes, Meike M.C., Vleggaar, Frank P., and Siersema, Peter D.

Published
2017
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31. Short-term and Long-term Outcomes of a Disruption and Disconnection of the Pancreatic Duct in Necrotizing Pancreatitis: A Multicenter Cohort Study in 896 Patients.

Author

Timmerhuis, Hester C., van Dijk, Sven M., Hollemans, Robbert A., Weiland, Christina J. Sperna, Umans, Devica S., Boxhoorn, Lotte, Hallensleben, Nora H., van der Sluijs, Rogier, Brouwer, Lieke, van Duijvendijk, Peter, Kager, Liesbeth, Kuiken, Sjoerd, Poley, Jan-Werner, de Ridder, Rogier, Römkens, Tessa E. H., Quispel, Rutger, Schwartz, Matthijs P., Tan, Adriaan C. I. T. L., Venneman, Niels G., and Vleggaar, Frank P.

Published
2023
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32. Comparison of lumen-apposing metal stents versus double-pigtail plastic stents for infected necrotising pancreatitis

Author

Boxhoorn, Lotte, primary, Verdonk, Robert C, additional, Besselink, Marc G, additional, Boermeester, Marja, additional, Bollen, Thomas L, additional, Bouwense, Stefan AW, additional, Cappendijk, Vincent C, additional, Curvers, Wouter L, additional, Dejong, Cornelis H, additional, van Dijk, Sven M, additional, van Dullemen, Hendrik M, additional, van Eijck, Casper HJ, additional, van Geenen, Erwin JM, additional, Hadithi, Muhammed, additional, Hazen, Wouter L, additional, Honkoop, Pieter, additional, van Hooft, Jeanin E, additional, Jacobs, Maarten AJM, additional, Kievits, June EC, additional, Kop, Marnix PM, additional, Kouw, Eva, additional, Kuiken, Sjoerd D, additional, Ledeboer, Michiel, additional, Nieuwenhuijs, Vincent B, additional, Perk, Lars E, additional, Poley, Jan-Werner, additional, Quispel, Rutger, additional, de Ridder, Rogier JJ, additional, van Santvoort, Hjalmar C, additional, Sperna Weiland, Christina J, additional, Stommel, Martijn WJ, additional, Timmerhuis, Hester C, additional, Witteman, Ben J, additional, Umans, Devica S, additional, Venneman, Niels G, additional, Vleggaar, Frank P, additional, van Wanrooij, Roy LJ, additional, Bruno, Marco J, additional, Fockens, Paul, additional, and Voermans, Rogier P, additional

Published
2022
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33. Corrigendum to ‘A mixed-methods study to define Textbook Outcome for the treatment of patients with uncomplicated symptomatic gallstone disease with hospital variation analyses in Dutch trial data’ [Volume 25, Issue 9, September 2023, Pages 1000–1010]

Author

Eijsbouts, Quirijn A.J., Heisterkamp, Joos, Boerma, Djamila, Jennifer, M.J., van Duivendijk, Peter, Wiering, Bastiaan, Boermeester, Marja A., Diepenhorst, Gwen, van der Bilt, Jarmila, Buyne, Otmar, Venneman, Niels G., Keszthelyi, Daniel, Ahmed, Ifran, Hugh, Thomas J., Wigmore, Stephen J., Strasberg, Steven M., Harrison, Ewen M., Lammert, Frank, Gurusamy, Kurinchi, Moris, Dimitros, Soreide, Kjetil, Pappas, Theodore N., Kapoor, Vinay K., Speelman, Antonia, van den Brink, Chris, Thunnissen, Floris M., Comes, Daan J., Latenstein, Carmen S.S., Stommel, Martijn W.J., van Laarhoven, Cornelis J.H.M., Drenth, Joost P.H., Lantinga, Marten A., Atsma, Femke, and de Reuver, Philip R.

Published
2024
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34. Aggressive fluid hydration plus non-steroidal anti-inflammatory drugs versus non-steroidal anti-inflammatory drugs alone for post-endoscopic retrograde cholangiopancreatography pancreatitis (FLUYT):a multicentre, open-label, randomised, controlled trial

Author

Sperna Weiland, Christina J., Smeets, Xavier J.N.M., Kievit, Wietske, Verdonk, Robert C., Poen, Alexander C., Bhalla, Abha, Venneman, Niels G., Witteman, Ben J.M., da Costa, David W., van Eijck, Brechje C., Schwartz, Matthijs P., Römkens, Tessa E.H., Vrolijk, Jan Maarten, Hadithi, Muhammed, Voorburg, Annet M.C.J., Baak, Lubbertus C., Thijs, Willem J., van Wanrooij, Roy L., Tan, Adriaan C.I.T.L., Seerden, Tom C.J., Keulemans, Yolande C.A., de Wijkerslooth, Thomas R., van de Vrie, Wim, van der Schaar, Peter, van Dijk, Sven M., Hallensleben, Nora D.L., Sperna Weiland, Ruud L., Timmerhuis, Hester C., Umans, Devica S., van Hooft, Jeanin E., van Goor, Harry, van Santvoort, Hjalmar C., Besselink, Marc G., Bruno, Marco J., Fockens, Paul, Drenth, Joost P.H., van Geenen, Erwin J.M., Sperna Weiland, Christina J., Smeets, Xavier J.N.M., Kievit, Wietske, Verdonk, Robert C., Poen, Alexander C., Bhalla, Abha, Venneman, Niels G., Witteman, Ben J.M., da Costa, David W., van Eijck, Brechje C., Schwartz, Matthijs P., Römkens, Tessa E.H., Vrolijk, Jan Maarten, Hadithi, Muhammed, Voorburg, Annet M.C.J., Baak, Lubbertus C., Thijs, Willem J., van Wanrooij, Roy L., Tan, Adriaan C.I.T.L., Seerden, Tom C.J., Keulemans, Yolande C.A., de Wijkerslooth, Thomas R., van de Vrie, Wim, van der Schaar, Peter, van Dijk, Sven M., Hallensleben, Nora D.L., Sperna Weiland, Ruud L., Timmerhuis, Hester C., Umans, Devica S., van Hooft, Jeanin E., van Goor, Harry, van Santvoort, Hjalmar C., Besselink, Marc G., Bruno, Marco J., Fockens, Paul, Drenth, Joost P.H., and van Geenen, Erwin J.M.

Abstract

Background: Pancreatitis is the most common complication of endoscopic retrograde cholangiopancreatography (ERCP). Prophylactic rectal administration of non-steroidal anti-inflammatory drugs (NSAIDs) is considered as standard of care to reduce the risk of post-ERCP pancreatitis. It has been suggested that aggressive hydration might further reduce this risk. Guidelines already recommend aggressive hydration in patients who are unable to receive rectal NSAIDs, although it is laborious and time consuming. We aimed to evaluate the added value of aggressive hydration in patients receiving prophylactic rectal NSAIDs. Methods: FLUYT, a multicentre, open-label, randomised, controlled trial done across 22 Dutch hospitals, included patients aged between 18 and 85 years with moderate to high risk of post-ERCP pancreatitis. Patients were randomly assigned (1:1) by a web-based module with varying block sizes to a combination of aggressive hydration and rectal NSAIDs (100 mg diclofenac or indomethacin; aggressive hydration group) or rectal NSAIDs (100 mg diclofenac or indomethacin) alone (control group). Randomisation was stratified according to treatment centre. Aggressive hydration comprised 20 mL/kg intravenous Ringer's lactate solution within 60 min from the start of ERCP, followed by 3 mL/kg per h for 8 h. The control group received normal intravenous saline with a maximum of 1·5 mL/kg per h and 3 L per 24 h. The primary endpoint was post-ERCP pancreatitis and was analysed on a modified intention-to-treat basis (including all patients who underwent randomisation and an ERCP and for whom data regarding the primary outcome were available). The trial is registered with the ISRCTN registry, ISRCTN13659155. Findings: Between June 5, 2015, and June 6, 2019, 826 patients were randomly assigned, of whom 388 in the aggressive hydration group and 425 in the control group were included in the modified intention-to-treat analysis. Post-ERCP pancreatitis occurred in 30 (8%) patients i

Published
2021

35. Nationwide practice and outcomes of endoscopic biliary drainage in resectable pancreatic head and periampullary cancer

Author

Latenstein, Anouk E. J., Mackay, Tara M., van Huijgevoort, Nadine C. M., Bonsing, Bert A., Bosscha, Koop, Hol, Lieke, Bruno, Marco J., van Coolsen, Marielle M. E., Festen, Sebastiaan, van Geenen, Erwin, Koerkamp, Bas Groot, Hemmink, Gerrit J. M., de Hingh, Ignace H. J. T., Kazemier, Geert, Lubbinge, Hans, de Meijer, Vincent E., Molenaar, I. Quintus, Quispel, Rutger, van Santvoort, Hjalmar C., Seerden, Tom C. J., Stommel, Martijn W. J., Venneman, Niels G., Verdonk, Robert C., Besselink, Marc G., van Hooft, Jeanin E., Latenstein, Anouk E. J., Mackay, Tara M., van Huijgevoort, Nadine C. M., Bonsing, Bert A., Bosscha, Koop, Hol, Lieke, Bruno, Marco J., van Coolsen, Marielle M. E., Festen, Sebastiaan, van Geenen, Erwin, Koerkamp, Bas Groot, Hemmink, Gerrit J. M., de Hingh, Ignace H. J. T., Kazemier, Geert, Lubbinge, Hans, de Meijer, Vincent E., Molenaar, I. Quintus, Quispel, Rutger, van Santvoort, Hjalmar C., Seerden, Tom C. J., Stommel, Martijn W. J., Venneman, Niels G., Verdonk, Robert C., Besselink, Marc G., and van Hooft, Jeanin E.

Abstract

Background: Guidelines advise self-expanding metal stents (SEMS) over plastic stents in preoperative endoscopic biliary drainage (EBD) for malignant extrahepatic biliary obstruction. This study aims to assess nationwide practice and outcomes.Methods: Patients with pancreatic head and periampullary cancer who underwent EBD before pancreatoduodenectomy were included from the Dutch Pancreatic Cancer Audit (2017-2018). Multi variable logistic and linear regression models were performed.Results: In total, 575/1056 patients (62.0%) underwent preoperative EBD: 246 SEMS (42.8%) and 329 plastic stents (57.2%). EBD-related complications were comparable between the groups (44/246 (17.9%) vs. 64/329 (19.5%), p = 0.607), including pancreatitis (22/246 (8.9%) vs. 25/329 (7.6%), p = 0.387). EBD-related cholangitis was reduced after SEMS placement (10/246 (4.1%) vs. 32/329 (9.7%), p = 0.043), which was confirmed in multivariable analysis (OR 0.36 95%CI 0.15-0.87, p = 0.023). Major postoperative complications did not differ (58/246 (23.6%) vs. 90/329 (27.4%), p = 0.316), whereas postoperative pancreatic fistula (24/246 (9.8%) vs. 61/329 (18.5%), p = 0.004; OR 0.50 95%CI 0.27-0.94, p = 0.031) and hospital stay (14.0 days vs. 17.4 days, p = 0.005; B 2.86 95%CI -5.16 to -0.57, p = 0.014) were less after SEMS placement.Conclusion: This study found that preoperative EBD frequently involved plastic stents. SEMS seemed associated with lower risks of cholangitis and less postoperative pancreatic fistula, but without an increased pancreatitis risk.

Published
2021

37. Comparison of lumen-apposing metal stents versus double-pigtail plastic stents for infected necrotising pancreatitis

Author

Boxhoorn, Lotte, Verdonk, Robert C, Besselink, Marc G, Boermeester, Marja, Bollen, Thomas L, Bouwense, Stefan AW, Cappendijk, Vincent C, Curvers, Wouter L, Dejong, Cornelis H, van Dijk, Sven M, van Dullemen, Hendrik M, van Eijck, Casper HJ, van Geenen, Erwin JM, Hadithi, Muhammed, Hazen, Wouter L, Honkoop, Pieter, van Hooft, Jeanin E, Jacobs, Maarten AJM, Kievits, June EC, Kop, Marnix PM, Kouw, Eva, Kuiken, Sjoerd D, Ledeboer, Michiel, Nieuwenhuijs, Vincent B, Perk, Lars E, Poley, Jan-Werner, Quispel, Rutger, de Ridder, Rogier JJ, van Santvoort, Hjalmar C, Sperna Weiland, Christina J, Stommel, Martijn WJ, Timmerhuis, Hester C, Witteman, Ben J, Umans, Devica S, Venneman, Niels G, Vleggaar, Frank P, van Wanrooij, Roy LJ, Bruno, Marco J, Fockens, Paul, and Voermans, Rogier P

Abstract

ObjectiveLumen-apposing metal stents (LAMS) are believed to clinically improve endoscopic transluminal drainage of infected necrosis when compared with double-pigtail plastic stents. However, comparative data from prospective studies are very limited.DesignPatients with infected necrotising pancreatitis, who underwent an endoscopic step-up approach with LAMS within a multicentre prospective cohort study were compared with the data of 51 patients in the randomised TENSION trial who had been assigned to the endoscopic step-up approach with double-pigtail plastic stents. The clinical study protocol was otherwise identical for both groups. Primary end point was the need for endoscopic transluminal necrosectomy. Secondary end points included mortality, major complications, hospital stay and healthcare costs.ResultsA total of 53 patients were treated with LAMS in 16 hospitals during 27 months. The need for endoscopic transluminal necrosectomy was 64% (n=34) and was not different from the previous trial using plastic stents (53%, n=27)), also after correction for baseline characteristics (OR 1.21 (95% CI 0.45 to 3.23)). Secondary end points did not differ between groups either, which also included bleeding requiring intervention—5 patients (9%) after LAMS placement vs 11 patients (22%) after placement of plastic stents (relative risk 0.44; 95% CI 0.16 to 1.17). Total healthcare costs were also comparable (mean difference −€6348, bias-corrected and accelerated 95% CI −€26 386 to €10 121).ConclusionOur comparison of two patient groups from two multicentre prospective studies with a similar design suggests that LAMS do not reduce the need for endoscopic transluminal necrosectomy when compared with double-pigtail plastic stents in patients with infected necrotising pancreatitis. Also, the rate of bleeding complications was comparable.

Published
2023
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38. ID: 3520219 A RANDOMIZED TRIAL OF AGGRESSIVE FLUID HYDRATION TO PREVENT POST-ERCP PANCREATITIS (FLUYT)

Author

Sperna Weiland, Christa J., primary, Smeets, Xavier, additional, Kievit, Wietske, additional, Verdonk, Robert C., additional, Poen, A.C., additional, Bhalla, Abha, additional, Venneman, Niels G., additional, Witteman, Ben, additional, da Costa, David W., additional, van Eijck, Brechje, additional, Schwartz, Matthijs P., additional, Romkens, Tessa, additional, Vrolijk, Jan, additional, Hadithi, Muhammed, additional, Voorburg, Annet, additional, Baak, Lubbertus C., additional, Thijs, Willem, additional, Wanrooij, Roy V., additional, Tan, Adriaan C., additional, Seerden, Tom, additional, Keulemans, Yolande, additional, De Wijkerslooth, Thomas R., additional, Van De Vrie, W., additional, Van Der Schaar, Peter J., additional, Van Dijk, Sven M., additional, Hallensleben, Nora D., additional, Sperna Weiland, Ruud L., additional, Timmerhuis, Hester C., additional, Umans, Devica S., additional, van Hooft, Jeanin E., additional, van Goor, Harry, additional, Van Santvoort, Hjalmar C., additional, Besselink, Marc G., additional, Bruno, Marco J., additional, Fockens, Paul, additional, Drenth, Joost, additional, and Van Geenen, Erwin-Jan M., additional

Published
2021
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39. ID: 3519933 LUMEN-APPOSING METAL STENTS VERSUS DOUBLE-PIGTAIL PLASTIC STENTS IN THE ENDOSCOPIC STEP-UP APPROACH FOR INFECTED NECROTIZING PANCREATITIS

Author

Boxhoorn, Lotte, primary, Verdonk, Robert C., additional, Besselink, Marc G., additional, Boermeester, Marja A., additional, Bollen, Thomas, additional, Bouwense, Stefan A., additional, Cappendijk, Vincent C., additional, Curvers, Wouter, additional, Dejong, Cornelis H., additional, van Dijk, Sven M., additional, Van Dullemen, Hendrik M., additional, Van Eijck, Casper H., additional, Van Geenen, Erwin-Jan M., additional, Hadithi, Muhammed, additional, Hazen, Wouter L., additional, Honkoop, Pieter, additional, van Hooft, Jeanin E., additional, Jacobs, Maarten, additional, Kouw, Eva, additional, Kuiken, Sjoerd D., additional, Ledeboer, Michiel, additional, Nieuwenhuijs, Vincent B., additional, Perk, Lars, additional, Poley, Jan-Werner, additional, Quispel, Rutger, additional, De Ridder, Rogier, additional, Van Santvoort, Hjalmar C., additional, Stommel, Martijn W.J., additional, Timmerhuis, Hester C., additional, Witteman, Ben, additional, Umans, Devica S., additional, Venneman, Niels G., additional, Vleggaar, Frank P., additional, Wanrooij, Roy V., additional, Sperna Weiland, Christina J., additional, Bruno, Marco J., additional, Fockens, Paul, additional, and Voermans, Rogier P., additional

Published
2021
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41. Sa283 ENDOSCOPIC VERSUS SURGICAL STEP-UP APPROACH FOR INFECTED NECROTIZING PANCREATITIS: LONG-TERM FOLLOW-UP OF A MULTICENTER RANDOMIZED CONTROLLED TRIAL (EXTENSION)

Author

Onnekink, Anke M., primary, Boxhoorn, Lotte, additional, Bac, Simon, additional, Timmerhuis, Hester C., additional, Besselink, Marc G., additional, Boermeester, Marja A., additional, Bollen, Thomas, additional, Bosscha, Koop, additional, Bouwense, Stefan A., additional, Bruno, Marco J., additional, Van Brunschot, Sandra, additional, Cappendijk, Vincent C., additional, Consten, Esther, additional, Dejong, Cornelis H., additional, Dijkgraaf, Marcel, additional, Van Eijck, Casper H., additional, Erkelens, G. Willemien, additional, van Goor, Harry, additional, van Grevenstein, Helma, additional, van Grinsven, Janneke, additional, Haveman, Jan illem, additional, Hofker, Sijbrand H., additional, Jansen, Jeroen M., additional, van Lienden, Krijn P., additional, Meijssen, Maarten, additional, Wanrooij, Roy V., additional, Nieuwenhuijs, Vincent B., additional, Poley, Jan-Werner, additional, Quispel, Rutger, additional, De Ridder, Rogier, additional, Romkens, Tessa, additional, Van Santvoort, Hjalmar C., additional, Scheepers, Joris J., additional, Schwartz, Matthijs P., additional, Seerden, Tom, additional, Spanier, Marcel, additional, Straathof, Jan Willem, additional, Timmer, Robin, additional, Venneman, Niels G., additional, Verdonk, Robert C., additional, Vleggaar, Frank P., additional, Witteman, Ben, additional, Fockens, Paul, additional, and Voermans, Rogier P., additional

Published
2021
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42. Fr289 POSTPONED OR IMMEDIATE DRAINAGE OF INFECTED NECROTIZING PANCREATITIS (POINTER): A MULTICENTER RANDOMIZED TRIAL

Author

Boxhoorn, Lotte, primary, van Dijk, Sven M., additional, van Grinsven, Janneke, additional, Verdonk, Robert C., additional, Boermeester, Marja A., additional, Bollen, Thomas, additional, Bouwense, Stefan A., additional, Bruno, Marco J., additional, Cappendijk, Vincent C., additional, Dejong, Cornelis H., additional, Duijvendijk, Peter V., additional, Van Eijck, Casper H., additional, Fockens, Paul, additional, Francken, Michiel F.G., additional, van Goor, Harry, additional, Hadithi, Muhammed, additional, Hallensleben, Nora D., additional, Haveman, Jan illem, additional, Jacobs, Maarten, additional, Jansen, Jeroen M., additional, Kop, Marnix P.M., additional, van Lienden, Krijn P., additional, Manusama, Eric R., additional, Mieog, J.S., additional, Molenaar, Quintus, additional, Nieuwenhuijs, Vincent B., additional, Poen, A.C., additional, Poley, Jan-Werner, additional, van de Poll, Marcel, additional, Quispel, Rutger, additional, Romkens, Tessa E.H, additional, Schwartz, Matthijs P., additional, Seerden, Tom, additional, Stommel, Martijn W.J., additional, Straathof, Jan Willem, additional, Timmerhuis, Hester C., additional, Venneman, Niels G., additional, Voermans, Rogier P., additional, Van De Vrie, W, additional, Witteman, Ben, additional, Dijkgraaf, Marcel G., additional, Van Santvoort, Hjalmar C., additional, and Besselink, Marc G., additional

Published
2021
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45. Role of endoscopic ultrasonography in the diagnostic work-up of idiopathic acute pancreatitis (PICUS): study protocol for a nationwide prospective cohort study

Author

Umans, Devica S, primary, Timmerhuis, Hester C, additional, Hallensleben, Nora D, additional, Bouwense, Stefan A, additional, Anten, Marie-Paule GF, additional, Bhalla, Abha, additional, Bijlsma, Rina A, additional, Boermeester, Marja A, additional, Brink, Menno A, additional, Hol, Lieke, additional, Bruno, Marco J, additional, Curvers, Wouter L, additional, van Dullemen, Hendrik M, additional, van Eijck, Brechje C, additional, Erkelens, G Willemien, additional, Fockens, Paul, additional, van Geenen, Erwin J M, additional, Hazen, Wouter L, additional, Hoge, Chantal V, additional, Inderson, Akin, additional, Kager, Liesbeth M, additional, Kuiken, Sjoerd D, additional, Perk, Lars E, additional, Poley, Jan-Werner, additional, Quispel, Rutger, additional, Römkens, Tessa EH, additional, van Santvoort, Hjalmar C, additional, Tan, Adriaan CITL, additional, Thijssen, Annemieke Y, additional, Venneman, Niels G, additional, Vleggaar, Frank P, additional, Voorburg, Annet MCJ, additional, van Wanrooij, Roy LJ, additional, Witteman, Ben J, additional, Verdonk, Robert C, additional, Besselink, Marc G, additional, and van Hooft, Jeanin E, additional

Published
2020
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46. Urgent endoscopic retrograde cholangiopancreatography with sphincterotomy versus conservative treatment in predicted severe acute gallstone pancreatitis (APEC): a multicentre randomised controlled trial

Author

Schepers, Nicolien J, primary, Hallensleben, Nora D L, additional, Besselink, Marc G, additional, Anten, Marie-Paule G F, additional, Bollen, Thomas L, additional, da Costa, David W, additional, van Delft, Foke, additional, van Dijk, Sven M, additional, van Dullemen, Hendrik M, additional, Dijkgraaf, Marcel G W, additional, van Eijck, Casper H J, additional, Erkelens, G Willemien, additional, Erler, Nicole S, additional, Fockens, Paul, additional, van Geenen, Erwin J M, additional, van Grinsven, Janneke, additional, Hollemans, Robbert A, additional, van Hooft, Jeanin E, additional, van der Hulst, Rene W M, additional, Jansen, Jeroen M, additional, Kubben, Frank J G M, additional, Kuiken, Sjoerd D, additional, Laheij, Robert J F, additional, Quispel, Rutger, additional, de Ridder, Rogier J J, additional, Rijk, Marno C M, additional, Römkens, Tessa E H, additional, Ruigrok, Carola H M, additional, Schoon, Erik J, additional, Schwartz, Matthijs P, additional, Smeets, Xavier J N M, additional, Spanier, B W Marcel, additional, Tan, Adriaan C I T L, additional, Thijs, Willem J, additional, Timmer, Robin, additional, Venneman, Niels G, additional, Verdonk, Robert C, additional, Vleggaar, Frank P, additional, van de Vrie, Wim, additional, Witteman, Ben J, additional, van Santvoort, Hjalmar C, additional, Bakker, Olaf J, additional, and Bruno, Marco J, additional

Published
2020
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50. Increased Use of Prophylactic Measures in Preventing Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis.

Author

Sperna Weiland, Christina J., Engels, Megan M. L., Poen, Alexander C., Bhalla, Abha, Venneman, Niels G., van Hooft, Jeanin E., Bruno, Marco J., Verdonk, Robert C., Fockens, Paul, Drenth, Joost P. H., and van Geenen, Erwin J. M.

Subjects
PANCREATIC duct, CHRONIC pancreatitis, PANCREATITIS, ANTI-inflammatory agents, NONSTEROIDAL anti-inflammatory agents, INJECTIONS
Abstract

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs), pancreatic duct stenting, and intensive intravenous hydration have been proven to prevent post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. Trial participation and guideline changes demanded an assessment of the clinical practice of post-ERCP pancreatitis prophylaxis. Aims: The surveys aim to identify points of improvement to inform and educate ERCPists about current evidence-based practice. Methods: Two anonymous surveys were conducted among Dutch gastroenterologists in 2013 (n = 408) and 2020 (n = 575) for longitudinal views and attitudes pertaining to post-ERCP pancreatitis prophylaxis and recognition of post-ERCP pancreatitis risk factors. Results: In 2013 and 2020, respectively, 121 and 109 ERCPists responded. In the 2013 survey, 98% of them utilized NSAID prophylaxis and 62% pancreatic duct stent prophylaxis in specific cases. In the 2020 survey, the use of NSAIDs (100%), pancreatic duct stents (78%), and intensive intravenous hydration (33%) increased among ERCPists. NSAID prophylaxis was the preferred prophylactic measure for all risk factors in the 2020 survey, except for ampullectomy, pancreatic duct contrast injection, and pancreatic duct cannulation, for which NSAID prophylaxis and pancreatic duct stent combined was equally favored or preferred. Conclusion: Rectal NSAIDs are the most applied post-ERCP pancreatitis prophylaxis in the Netherlands, followed by pancreatic duct stents and intensive intravenous hydration. Additionally, there is reason to believe that recent guideline updates and active research participation have led to increased prophylaxis implementation. [ABSTRACT FROM AUTHOR]

Published
2021
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