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3 results on '"Venkata R. Pothineni"'

1. List of Contributors

Author

Hasan Afzaal, Amjad Ali, Zeeshan Ali, Jaspreet S. Arora, Kulanthaiyesu Arunkumar, Marcela S.P. Azevedo, Vasco Azevedo, Mustafeez M. Babar, Debmalya Barh, Kartikay Bisen, Isabel S. Carvalho, Rekha Chawla, Karthik Chinnannan, Ana Coelho, Sintia S. De Almeida, Siomar De Castro Soares, Alejandra de Moreno de LeBlanc, Cassiana S. De Sousa, Rajesh K. Dubey, Atul Grover, Alvina Gul, Sanjay M. Gupta, Syed S. Hassan, Yousef I. Hassan, Shahid Iqbal, Rija Irfan, Jyoti S. Jadaun, Anu Kalia, Chetan Keswani, Faria Khan, Md Gulam M. Khan, Surender Khatodia, Sathiya Kumar, Sekar Kumaran, Jean Guy LeBlanc, Tessalia D. Luerce, Lekha C. Meher, Mohammad F. Miah, Zujaja T. Misbah, Bhawana Mishra, Anderson Miyoshi, Chandra S. Mukhopadhyay, Anjana Munshi, Malik G. Mustafa, Lokesh K. Narnoliya, Mohammed Nasim, Duy Nguyen, Ricardo Nunes, Indra A. Padikasan, Sajida Parveen, Vikas Y. Patade, S.M. Paul Khurana, Anne C. Pinto, Venkata R. Pothineni, Raja Rathinam, Ratul M. Ram, Clarissa S. Rocha, Pavel Samuleev, Neelam S. Sangwan, Rajender S. Sangwan, Ramaraj Sathasivam, Kanwal Shaheen, Hemaiswarya Shanmugam, Manju Sharma, S.P. Sharma, Vandana Sharma, Wanderson M. Silva, Harikesh B. Singh, Surya P. Singh, Govindaraju Subramaniyan, Natesan Sudhakar, Tehreem Tanveer, Ruchi Tripathi, Sandhya Tripathi, Daria Trofimova, Kinza Waqar, Muhammad A. Zahid, Najam-us-Sahar S. Zaidi, and Ting Zhou

Published
2018

2. Microhemorrhage-associated tissue iron enhances the risk for

Author

Joe L, Hsu, Olga V, Manouvakhova, Karl V, Clemons, Mohammed, Inayathullah, Allen B, Tu, Raymond A, Sobel, Amy, Tian, Hasan, Nazik, Venkata R, Pothineni, Shravani, Pasupneti, Xinguo, Jiang, Gundeep S, Dhillon, Harmeet, Bedi, Jayakumar, Rajadas, Hubertus, Haas, Laure, Aurelian, David A, Stevens, and Mark R, Nicolls

Subjects
Male, Mice, Inbred C57BL, Disease Models, Animal, Mice, Mice, Inbred BALB C, Aspergillus fumigatus, Iron, Animals, Aspergillosis, respiratory system, Lung, Article, Lung Transplantation
Abstract

Invasive pulmonary disease due to the mold Aspergillus fumigatus can be life-threatening in lung transplant recipients, but the risk factors remain poorly understood. To study this process, we used a tracheal allograft mouse model that recapitulates large airway changes observed in patients undergoing lung transplantation. We report that microhemorrhage-related iron content may be a major determinant of A. fumigatus invasion and, consequently, its virulence. Invasive growth was increased during progressive alloimmune-mediated graft rejection associated with high concentrations of ferric iron in the graft. The role of iron in A. fumigatus invasive growth was further confirmed by showing that this invasive phenotype was increased in tracheal transplants from donor mice lacking the hemochromatosis gene (Hfe−/−). The invasive phenotype was also increased in mouse syngrafts treated with topical iron solution and in allograft recipients receiving deferoxamine, a chelator that increases iron bioavailability to the mold. The invasive growth of the iron-intolerant A. fumigatus double-knockout mutant (ΔsreA/ΔcccA) was lower than that of the wild-type mold. Alloimmune-mediated microvascular damage and iron overload did not appear to impair the host’s immune response. In human lung transplant recipients, positive staining for iron in lung transplant tissue was more commonly seen in endobronchial biopsy sections from transplanted airways than in biopsies from the patients’ own airways. Collectively, these data identify iron as a major determinant of A. fumigatus invasive growth and a potential target to treat or prevent A. fumigatus infections in lung transplant patients.

Published
2016

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