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1. Non-Small Cell Lung Cancer Testing on Reference Specimens: An Italian Multicenter Experience

Author

Pepe, Francesco, Russo, Gianluca, Venuta, Alessandro, Scimone, Claudia, Nacchio, Mariantonia, Pisapia, Pasquale, Goteri, Gaia, Barbisan, Francesca, Chiappetta, Caterina, Pernazza, Angelina, Campagna, Domenico, Giordano, Marco, Perrone, Giuseppe, Sabarese, Giovanna, Altimari, Annalisa, de Biase, Dario, Tallini, Giovanni, Calistri, Daniele, Chiadini, Elisa, Capelli, Laura, Santinelli, Alfredo, Gulini, Anna Elisa, Pierpaoli, Elisa, Badiali, Manuela, Murru, Stefania, Murgia, Riccardo, Guerini Rocco, Elena, Venetis, Konstantinos, Fusco, Nicola, Morotti, Denise, Gianatti, Andrea, Furlan, Daniela, Rossi, Giulio, Melocchi, Laura, Russo, Maria, De Luca, Caterina, Palumbo, Lucia, Simonelli, Saverio, Maffè, Antonella, Francia di Celle, Paola, Venesio, Tiziana, Scatolini, Maria, Grosso, Enrico, Orecchia, Sara, Fassan, Matteo, Balistreri, Mariangela, Zulato, Elisabetta, Reghellin, Daniela, Lazzari, Elena, Santacatterina, Maria, Piredda, Maria Liliana, Riccardi, Manuela, Laurino, Licia, Roz, Elena, Longo, Domenico, Romeo, Daniela Petronilla, Fazzari, Carmine, Moreno-Manuel, Andrea, Puglia, Giuseppe Diego, Prjibelski, Andrey D., Shafranskaya, Daria, Righi, Luisella, Listì, Angela, Vitale, Domenico, Iaccarino, Antonino, Malapelle, Umberto, and Troncone, Giancarlo

Published
2024
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4. Unveiling the impact of circulating tumor cells: Two decades of discovery and clinical advancements in solid tumors

Author

Reduzzi, Carolina, Nicolo’, Eleonora, Singhal, Surbhi, Venetis, Konstantinos, Ortega-Franco, Ana, de Miguel-Perez, Diego, Dipasquale, Angelo, Gouda, Mohamed A., Saldanha, Erick F., Kasi, Pashtoon M., Jantus-Lewintre, Eloisa, Fusco, Nicola, Malapelle, Umberto, Gandara, David R., Rolfo, Christian, Serrano, Maria Jose, and Cristofanilli, Massimo

Published
2024
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5. Multi-omics integrative modelling for stereotactic body radiotherapy in early-stage non-small cell lung cancer: clinical trial protocol of the MONDRIAN study

Author

Volpe, Stefania, Zaffaroni, Mattia, Piperno, Gaia, Vincini, Maria Giulia, Zerella, Maria Alessia, Mastroleo, Federico, Cattani, Federica, Fodor, Cristiana Iuliana, Bellerba, Federica, Bonaldi, Tiziana, Bonizzi, Giuseppina, Ceci, Francesco, Cremonesi, Marta, Fusco, Nicola, Gandini, Sara, Garibaldi, Cristina, Torre, Davide La, Noberini, Roberta, Petralia, Giuseppe, Spaggiari, Lorenzo, Venetis, Konstantinos, Orecchia, Roberto, Casiraghi, Monica, and Jereczek-Fossa, Barbara Alicja

Published
2023
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8. Clinicopathological features and survival outcomes of luminal-like breast tumors with estrogen receptor loss at metastatic recurrence: A case-control study

Author

Morganti, Stefania, Marra, Antonio, Gandini, Sara, Ascione, Liliana, Ivanova, Mariia, Venetis, Konstantinos, Sajjadi, Elham, Zagami, Paola, Giugliano, Federica, Taurelli Salimbeni, Beatrice, Berton Giachetti, Pier Paolo Maria, Corti, Chiara, De Camilli, Elisa, Curigliano, Giuseppe, Fusco, Nicola, and Criscitiello, Carmen

Published
2023
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9. Advancing the PD-L1 CPS test in metastatic TNBC: Insights from pathologists and findings from a nationwide survey

Author

Fusco, Nicola, Ivanova, Mariia, Frascarelli, Chiara, Criscitiello, Carmen, Cerbelli, Bruna, Pignataro, Maria Gemma, Pernazza, Angelina, Sajjadi, Elham, Venetis, Konstantinos, Cursano, Giulia, Pagni, Fabio, Di Bella, Camillo, Accardo, Marina, Amato, Michelina, Amico, Paolo, Bartoli, Caterina, Bogina, Giuseppe, Bortesi, Laura, Boldorini, Renzo, Bruno, Sara, Cabibi, Daniela, Caruana, Pietro, Dainese, Emanuele, De Camilli, Elisa, Dell’Anna, Vladimiro, Duda, Loren, Emmanuele, Carmela, Fanelli, Giuseppe Nicolò, Fernandes, Bethania, Ferrara, Gerardo, Gnetti, Letizia, Gurrera, Alessandra, Leone, Giorgia, Lucci, Raffaella, Mancini, Cristina, Marangi, Grazia, Mastropasqua, Mauro G., Nibid, Lorenzo, Orrù, Sandra, Pastena, Maria, Peresi, Monica, Perracchio, Letizia, Santoro, Angela, Vezzosi, Vania, Zambelli, Claudia, Zuccalà, Valeria, Rizzo, Antonio, Costarelli, Leopoldo, Pietribiasi, Francesca, Santinelli, Alfredo, Scatena, Cristian, Curigliano, Giuseppe, Guerini-Rocco, Elena, Martini, Maurizio, Graziano, Paolo, Castellano, Isabella, and d'Amati, Giulia

Published
2023
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12. The Evolving Role of Genomic Testing in Early Breast Cancer: Implications for Diagnosis, Prognosis, and Therapy

Author

Venetis, Konstantinos, primary, Pescia, Carlo, additional, Cursano, Giulia, additional, Frascarelli, Chiara, additional, Mane, Eltjona, additional, De Camilli, Elisa, additional, Munzone, Elisabetta, additional, Dellapasqua, Silvia, additional, Criscitiello, Carmen, additional, Curigliano, Giuseppe, additional, Guerini Rocco, Elena, additional, and Fusco, Nicola, additional

Published
2024
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13. Early Breast Cancer Risk Assessment: Integrating Histopathology with Artificial Intelligence

Author

Ivanova, Mariia, primary, Pescia, Carlo, additional, Trapani, Dario, additional, Venetis, Konstantinos, additional, Frascarelli, Chiara, additional, Mane, Eltjona, additional, Cursano, Giulia, additional, Sajjadi, Elham, additional, Scatena, Cristian, additional, Cerbelli, Bruna, additional, d’Amati, Giulia, additional, Porta, Francesca Maria, additional, Guerini-Rocco, Elena, additional, Criscitiello, Carmen, additional, Curigliano, Giuseppe, additional, and Fusco, Nicola, additional

Published
2024
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14. The Role of Liquid Biopsy as a Catalyst for Sustained Progress in Precision Oncology – Perspective of The Young Committee of The International Society of Liquid Biopsy

Author

Saldanha, Erick Figueiredo, primary, Nicolo, Eleonora, additional, Venetis, Konstantinos, additional, de Miguel-Perez, Diego, additional, Ortega-Fran, Ana, additional, Dipasquale, Angelo, additional, Gouda, Mohamed A., additional, Singal, Surbhi, additional, Adigbli, George, additional, and Reduzzi, Carolina, additional

Published
2024
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17. Rehabilitation for Functioning and Quality of Life in Patients with Malignant Pleural Mesothelioma: A Scoping Review.

Author

Lippi, Lorenzo, de Sire, Alessandro, Aprile, Vittorio, Calafiore, Dario, Folli, Arianna, Refati, Fjorelo, Balduit, Andrea, Mangogna, Alessandro, Ivanova, Mariia, Venetis, Konstantinos, Fusco, Nicola, and Invernizzi, Marco

Subjects
PHYSICAL mobility, PATIENT experience, EXERCISE tolerance, MEDICAL rehabilitation, PATIENTS' attitudes
Abstract

Malignant pleural mesothelioma (MPM) represents a significant clinical challenge due to limited therapeutic options and poor prognosis. Beyond mere survivorship, setting up an effective framework to improve functioning and quality of life is an urgent need in the comprehensive management of MPM patients. Therefore, this study aims to review the current understanding of MPM sequelae and the effectiveness of rehabilitative interventions in the holistic approach to MPM. A narrative review was conducted to summarize MPM sequelae and their impact on functioning, disability, and quality of life, focusing on rehabilitation interventions in MPM management and highlighting gaps in knowledge and areas for further investigation. Our findings showed that MPM patients experience debilitating symptoms, including fatigue, dyspnea, pain, and reduced exercise tolerance, decreasing quality of life. Supportive and rehabilitative interventions, including pulmonary rehabilitation, physical exercise improvement, psychological support, pain management, and nutritional supplementation, seem promising approaches in relieving symptoms and improving quality of life but require further research. These programs emphasize the pivotal synergy among patient-tailored plans, multidisciplinary team involvement, and disease-specific focus. Despite advancements in therapeutic management, MPM remains a challenging disease with limited effective interventions that should be adapted to disease progressions. Rehabilitative strategies are essential to mitigate symptoms and improve the quality of life in MPM patients. Further research is needed to establish evidence-based guidelines for rehabilitative interventions tailored to the unique needs of MPM patients. [ABSTRACT FROM AUTHOR]

Published
2024
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18. In-house homologous recombination deficiency testing in ovarian cancer: a multi-institutional Italian pilot study.

Author

Pepe, Francesco, Guerini-Rocco, Elena, Fassan, Matteo, Fusco, Nicola, Vacirca, Davide, Ranghiero, Alberto, Venetis, Konstantinos, Rappa, Alessandra, Taormina, Sergio Vincenzo, Russo, Gianluca, Rebellato, Elena, Munari, Giada, Moreno-Manuel, Andrea, De Angelis, Carmine, Zamagni, Claudio, Valabrega, Giorgio, Malapelle, Umberto, Troncone, Giancarlo, Barberis, Massimo, and Iaccarino, Antonino

Subjects
HOMOLOGOUS recombination, OVARIAN cancer, DEEP learning, INDUCED ovulation, DOUBLE-strand DNA breaks, PILOT projects
Published
2024
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19. PIK3CA testing in hormone receptor-positive/HER2-negative metastatic breast cancer: real-world data from Italian molecular pathology laboratories

Author

Pepe, Francesco, primary, Venetis, Konstantinos, additional, Cursano, Giulia, additional, Frascarelli, Chiara, additional, Pisapia, Pasquale, additional, Vacirca, Davide, additional, Scimone, Claudia, additional, Rappa, Alessandra, additional, Russo, Gianluca, additional, Mane, Eltjona, additional, Pagni, Fabio, additional, Castellano, Isabella, additional, Troncone, Giancarlo, additional, Angelis, Carmine De, additional, Curigliano, Giuseppe, additional, Guerini-Rocco, Elena, additional, Malapelle, Umberto, additional, and Fusco, Nicola, additional

Published
2024
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21. Think “HER2” different: integrative diagnostic approaches for HER2-low breast cancer

Author

Marchiò, Caterina, primary, Criscitiello, Carmen, additional, Scatena, Cristian, additional, Santinelli, Alfredo, additional, Graziano, Paolo, additional, Malapelle, Umberto, additional, Cursano, Giulia, additional, Venetis, Konstantinos, additional, Fanelli, Giuseppe Nicolò, additional, Pepe, Francesco, additional, Berrino, Enrico, additional, De Angelis, Carmine, additional, Perrone, Giuseppe, additional, Curigliano, Giuseppe, additional, and Fusco, Nicola, additional

Published
2023
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24. Standardized pathology report for HER2 testing in compliance with 2023 ASCO/CAP updates and 2023 ESMO consensus statements on HER2-low breast cancer

Author

Ivanova, Mariia, primary, Porta, Francesca Maria, additional, D’Ercole, Marianna, additional, Pescia, Carlo, additional, Sajjadi, Elham, additional, Cursano, Giulia, additional, De Camilli, Elisa, additional, Pala, Oriana, additional, Mazzarol, Giovanni, additional, Venetis, Konstantinos, additional, Guerini-Rocco, Elena, additional, Curigliano, Giuseppe, additional, Viale, Giuseppe, additional, and Fusco, Nicola, additional

Published
2023
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25. Circulating tumour DNA testing in metastatic breast cancer: Integration with tissue testing

Author

Ranghiero, Alberto, primary, Frascarelli, Chiara, additional, Cursano, Giulia, additional, Pescia, Carlo, additional, Ivanova, Mariia, additional, Vacirca, Davide, additional, Rappa, Alessandra, additional, Taormina, Sergio Vincenzo, additional, Barberis, Massimo, additional, Fusco, Nicola, additional, Rocco, Elena Guerini, additional, and Venetis, Konstantinos, additional

Published
2023
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26. Immune microenvironment dynamics in breast cancer during pregnancy: impact of gestational age on tumor-infiltrating lymphocytes and prognosis

Author

Sajjadi, Elham, primary, Venetis, Konstantinos, additional, Ivanova, Mariia, additional, Noale, Marianna, additional, Blundo, Concetta, additional, Di Loreto, Eugenia, additional, Scarfone, Giovanna, additional, Ferrero, Stefano, additional, Maggi, Stefania, additional, Veronesi, Paolo, additional, Galimberti, Viviana E., additional, Viale, Giuseppe, additional, Peccatori, Fedro A., additional, Fusco, Nicola, additional, and Guerini-Rocco, Elena, additional

Published
2023
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28. Trop-2 as an actionable biomarker in breast cancer

Author

Fusco, Nicola, primary, Cursano, Giulia, additional, Frigo, Emanuele, additional, Sajjadi, Elham, additional, Ivanova, Mariia, additional, Venetis, Konstantinos, additional, Guerini-Rocco, Elena, additional, Criscitiello, Carmen, additional, and Curigliano, Giuseppe, additional

Published
2023
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30. Breast Cancer with Brain Metastasis: Molecular Insights and Clinical Management

Author

Ivanova, Mariia, primary, Porta, Francesca Maria, additional, Giugliano, Federica, additional, Frascarelli, Chiara, additional, Sajjadi, Elham, additional, Venetis, Konstantinos, additional, Cursano, Giulia, additional, Mazzarol, Giovanni, additional, Guerini-Rocco, Elena, additional, Curigliano, Giuseppe, additional, Criscitiello, Carmen, additional, and Fusco, Nicola, additional

Published
2023
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32. In-house homologous recombination deficiency testing in ovarian cancer: a multi-institutional Italian pilot study

Author

Pepe, Francesco, primary, Guerini-Rocco, Elena, additional, Fassan, Matteo, additional, Fusco, Nicola, additional, Vacirca, Davide, additional, Ranghiero, Alberto, additional, Venetis, Konstantinos, additional, Rappa, Alessandra, additional, Taormina, Sergio Vincenzo, additional, Russo, Gianluca, additional, Rebellato, Elena, additional, Munari, Giada, additional, Moreno-Manuel, Andrea, additional, De Angelis, Carmine, additional, Zamagni, Claudio, additional, Valabrega, Giorgio, additional, Malapelle, Umberto, additional, Troncone, Giancarlo, additional, Barberis, Massimo, additional, and Iaccarino, Antonino, additional

Published
2023
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36. PIK3CAtesting in hormone receptor-positive/HER2-negative metastatic breast cancer: real-world data from Italian molecular pathology laboratories

Author

Pepe, Francesco, Venetis, Konstantinos, Cursano, Giulia, Frascarelli, Chiara, Pisapia, Pasquale, Vacirca, Davide, Scimone, Claudia, Rappa, Alessandra, Russo, Gianluca, Mane, Eltjona, Pagni, Fabio, Castellano, Isabella, Troncone, Giancarlo, Angelis, Carmine De, Curigliano, Giuseppe, Guerini-Rocco, Elena, Malapelle, Umberto, and Fusco, Nicola

Abstract

Introduction:PIK3CAgene mutations occur in approximately 40% of hormone receptor-positive/HER2-negative (HR+/HER2−) metastatic breast cancers (MBCs), electing them to targeted therapy. Testing PIK3CAstatus is complex due to selection of biological specimen and testing method. Materials & methods:This work investigates real-life experience on PIK3CAtesting in HR+/HER2−MBC. Clinical, technical and molecular data on PIK3CAtesting were collected from two referral laboratories. Additionally, the results of a nationwide PIK3CAsurvey involving 116 institutions were assessed. Results:Overall, n = 35 MBCs were PIK3CA-mutated, with mutations mostly occurring in exons 9 (n = 19; 51.4%) and 20 (n = 15; 40.5%). The nationwide survey revealed significant variability across laboratories in terms of sampling methodology, technical assessment and clinical report signing healthcare figures for PIK3CAmolecular testing in diagnostic routine practice. Conclusion:This study provides insights into the real-world routine of PIK3CAtesting in HR+/HER2−MBC and highlights the need for standardization and networking in predictive pathology.

Published
2024
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37. The molecular landscape of breast mucoepidermoid carcinoma

Author

Venetis, Konstantinos, primary, Sajjadi, Elham, additional, Ivanova, Mariia, additional, Andaloro, Silvia, additional, Pessina, Simona, additional, Zanetti, Chiara, additional, Ranghiero, Alberto, additional, Citelli, Gabriele, additional, Rossi, Chiara, additional, Lucioni, Marco, additional, Malapelle, Umberto, additional, Pagni, Fabio, additional, Barberis, Massimo, additional, Guerini‐Rocco, Elena, additional, Viale, Giuseppe, additional, and Fusco, Nicola, additional

Published
2023
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38. Abstract P6-04-14: Comparison of next-generation sequencing and real-time PCR for PIK3CA testing in hormone receptor-positive/HER2-negative breast cancer on metastatic and matched primary tumor samples

Author

Venetis, Konstantinos, primary, Pepe, Francesco, additional, Sajjadi, Elham, additional, Bonizzi, Giuseppina, additional, Ivanova, Mariia, additional, Vacirca, Davide, additional, Rappa, Alessandra, additional, Barberis, Massimo, additional, Viale, Giuseppe, additional, Guerini-Rocco, Elena, additional, Munzone, Elisabetta, additional, Malapelle, Umberto, additional, and Fusco, Nicola, additional

Published
2023
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39. Abstract P2-21-04: The tumor immune microenvironment composition and prognostic value in breast cancer during pregnancy is dynamic during the gestation period

Author

Sajjadi, Elham, primary, Venetis, Konstantinos, additional, Ivanova, Mariia, additional, Noale, Marianna, additional, Blundo, Concetta, additional, Scarfone, Giovanna, additional, Loreto, Eugenia Di, additional, Ferrero, Stefano, additional, Maggi, Stefania, additional, Veronesi, Paolo, additional, Galimbreti, Viviana Enrica, additional, Viale, Giuseppe, additional, Peccatori, Fedro Alessandro A., additional, Guerini-Rocco, Elena, additional, and Fusco, Nicola, additional

Published
2023
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41. Spatially Resolved Molecular Approaches for the Characterisation of Non-Invasive Follicular Tumours with Papillary-like Features (NIFTPs)

Author

Piga, Isabella, primary, L’Imperio, Vincenzo, additional, Principi, Lucrezia, additional, Bellevicine, Claudio, additional, Fusco, Nicola, additional, Maffini, Fausto, additional, Venetis, Konstantinos, additional, Ivanova, Mariia, additional, Seminati, Davide, additional, Casati, Gabriele, additional, Pagani, Lisa, additional, Galimberti, Stefania, additional, Capitoli, Giulia, additional, Garancini, Mattia, additional, Gatti, Andrea-Valer, additional, Magni, Fulvio, additional, and Pagni, Fabio, additional

Published
2023
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42. Diagnostic performance of image-guided vacuum-assisted breast biopsy after neoadjuvant therapy for breast cancer: prospective pilot study

Author

Rossi, Elisabetta M C, primary, Invento, Alessandra, additional, Pesapane, Filippo, additional, Pagan, Eleonora, additional, Bagnardi, Vincenzo, additional, Fusco, Nicola, additional, Venetis, Konstantinos, additional, Dominelli, Valeria, additional, Trentin, Chiara, additional, Cassano, Enrico, additional, Gilardi, Laura, additional, Mazza, Manuelita, additional, Lazzeroni, Matteo, additional, De Lorenzi, Francesca, additional, Caldarella, Pietro, additional, De Scalzi, Alessandra, additional, Girardi, Antonia, additional, Sangalli, Claudia, additional, Alberti, Luca, additional, Sacchini, Virgilio, additional, Galimberti, Viviana, additional, and Veronesi, Paolo, additional

Published
2022
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43. Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Author

Bonizzi, Giuseppina, primary, Capra, Maria, primary, Cassi, Cristina, primary, Taliento, Giulio, primary, Pala, Oriana, primary, Sajjadi, Elham, primary, Venetis, Konstantinos, primary, Ivanova, Mariia, primary, Monturano, Massimo, primary, Renne, Giuseppe, primary, Zattoni, Lorenzo, primary, Guerini-Rocco, Elena, primary, Viale, Giuseppe, primary, Orecchia, Roberto, primary, and Fusco, Nicola, primary

Published
2022
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44. Analytical Performance of Next-Generation Sequencing and RT-PCR on Formalin-Fixed Paraffin-Embedded Tumor Tissues for PIK3CA Testing in HR+/HER2− Breast Cancer

Author

Venetis, Konstantinos, primary, Pepe, Francesco, additional, Munzone, Elisabetta, additional, Sajjadi, Elham, additional, Russo, Gianluca, additional, Pisapia, Pasquale, additional, Ivanova, Mariia, additional, Bonizzi, Giuseppina, additional, Vacirca, Davide, additional, Rappa, Alessandra, additional, Ranghiero, Alberto, additional, Taormina, Sergio Vincenzo, additional, Viale, Giuseppe, additional, Troncone, Giancarlo, additional, Barberis, Massimo, additional, Guerini-Rocco, Elena, additional, Malapelle, Umberto, additional, and Fusco, Nicola, additional

Published
2022
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46. Osteoclast-like stromal giant cells in breast cancer likely belong to the spectrum of immunosuppressive tumor-associated macrophages

Author

Sajjadi, Elham, primary, Gaudioso, Gabriella, additional, Terrasi, Andrea, additional, Boggio, Francesca, additional, Venetis, Konstantinos, additional, Ivanova, Mariia, additional, Bertolasi, Letizia, additional, Lopez, Gianluca, additional, Runza, Letterio, additional, Premoli, Alice, additional, Lorenzini, Daniele, additional, Guerini-Rocco, Elena, additional, Ferrero, Stefano, additional, Vaira, Valentina, additional, and Fusco, Nicola, additional

Published
2022
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47. Breast Cancer during Pregnancy as a Special Type of Early-Onset Breast Cancer: Analysis of the Tumor Immune Microenvironment and Risk Profiles

Author

Sajjadi, Elham, primary, Venetis, Konstantinos, additional, Noale, Marianna, additional, Azim, Hatem A., additional, Blundo, Concetta, additional, Bonizzi, Giuseppina, additional, Di Loreto, Eugenia, additional, Scarfone, Giovanna, additional, Ferrero, Stefano, additional, Maggi, Stefania, additional, Barberis, Massimo, additional, Veronesi, Paolo, additional, Galimberti, Viviana E., additional, Viale, Giuseppe, additional, Fusco, Nicola, additional, Peccatori, Fedro A., additional, and Guerini-Rocco, Elena, additional

Published
2022
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48. Diagnostic performance of image-guided vacuum-assisted breast biopsy after neoadjuvant therapy for breast cancer: prospective pilot study.

Author

Rossi, Elisabetta M. C., Invento, Alessandra, Pesapane, Filippo, Pagan, Eleonora, Bagnardi, Vincenzo, Fusco, Nicola, Venetis, Konstantinos, Dominelli, Valeria, Trentin, Chiara, Cassano, Enrico, Gilardi, Laura, Mazza, Manuelita, Lazzeroni, Matteo, De Lorenzi, Francesca, Caldarella, Pietro, De Scalzi, Alessandra, Girardi, Antonia, Sangalli, Claudia, Alberti, Luca, and Sacchini, Virgilio

Subjects
BREAST biopsy, NEOADJUVANT chemotherapy, EPIDERMAL growth factor receptors, HER2 positive breast cancer, BREAST cancer, COLPOSCOPY
Abstract

Background: Image-guided vacuum-assisted breast biopsy (VABB) of the tumour bed, performed after neoadjuvant therapy, is increasingly being used to assess residual cancer and to potentially identify to identify pathological complete response (pCR). In this study, the accuracy of preoperative VABB specimens was assessed and compared with surgical specimens in patients with triple-negative or human epidermal growth factor receptor 2 (HER2)-positive invasive ductal breast cancer after neoadjuvant therapy. As a secondary endpoint, the performance of contrast-enhanced MRI of the breast and PET-CT for response prediction was assessed. Methods: This single-institution prospective pilot study enrolled patients from April 2018 to April 2021 with a complete response on imaging (iCR) who subsequently underwent VABB before surgery. Those with a pCR at VABB were included in the primary analysis of the accuracy of VABB. The performance of imaging (MRI and PET-CT) was analysed for prediction of a pCR considering both patients with an iCR and those with residual disease at postneoadjuvant therapy imaging. Results: Twenty patients were included in the primary analysis. The median age was 44 (range 35-51) years. At surgery, 18 of 20 patients showed a complete response (accuracy 90 (95 per cent exact c.i. 68 to 99) per cent). Only two patients showed residual ductal intraepithelial neoplasia of grade 2 and 3 respectively. In the secondary analysis, accuracy was similar for MRI and PET-CT (77 versus 78 per cent; P=0.76). Conclusion: VABB in patients with an iCR might be a promising method to select patients for de-escalation of surgical treatment in triple-negative or HER2-positive breast cancer. The present results support such an approach and should inform the design of future trials on de-escalation of surgery. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Tumor BRCA Testing in Epithelial Ovarian Cancers: Past and Future—Five-Years’ Single-Institution Experience of 762 Consecutive Patients

Author

Fumagalli, Caterina, primary, Betella, Ilaria, additional, Rappa, Alessandra, additional, di Giminiani, Maria, additional, Gaiano, Michela, additional, De Vitis, Luigi Antonio, additional, Zambetti, Benedetta, additional, Vacirca, Davide, additional, Multinu, Francesco, additional, Venetis, Konstantinos, additional, Colombo, Nicoletta, additional, Barberis, Massimo, additional, and Guerini Rocco, Elena, additional

Published
2022
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