1. Italian pool of asbestos workers cohorts: Mortality trends of asbestos-related neoplasms after long time since first exposure
- Author
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Simona Menegozzo, Dario Mirabelli, Francesco Cuccaro, Orietta Sala, Francesco Barone-Adesi, Daniela Ferrante, Vittoria Bressan, Lucia Miligi, Alessandro Marinaccio, Aldo Pettinari, Corrado Magnani, Paolo Girardi, Enzo Merler, Elisabetta Chellini, Venere Pavone, Alessandra Ranucci, Enrico Oddone, Patrizia Legittimo, Stefano Mattioli, Corrado Scarnato, Stefano Silvestri, Sara Tunesi, Laura Ancona, Patrizia Perticaroli, Roberta Pirastu, Marina Musti, Antonio Baldassarre, Tiziana Cena, Giuseppe Gorini, Elisa Romeo, Ferdinando Luberto, Ferrante, Daniela, Chellini, Elisabetta, Merler, Enzo, Pavone, Venere, Silvestri, Stefano, Miligi, Lucia, Gorini, Giuseppe, Bressan, Vittoria, Girardi, Paolo, Ancona, Laura, Romeo, Elisa, Luberto, Ferdinando, Sala, Orietta, Scarnato, Corrado, Menegozzo, Simona, Oddone, Enrico, Tunesi, Sara, Perticaroli, Patrizia, Pettinari, Aldo, Cuccaro, Francesco, Mattioli, Stefano, Baldassarre, Antonio, Barone-Adesi, Francesco, Cena, Tiziana, Legittimo, Patrizia, Marinaccio, Alessandro, Mirabelli, Dario, Musti, Marina, Pirastu, Roberta, Ranucci, Alessandra, Magnani, Corrado, [.., Curti, Stefania, and ]
- Subjects
Male ,Mesothelioma ,Occupational cancer ,Lung Neoplasms ,Asbestosis ,medicine.disease_cause ,Cohort Studies ,Economica ,0302 clinical medicine ,Cause of Death ,PLEURAL MESOTHELIOMA ,TEXTILE WORKERS ,Pleural Neoplasm ,Lung ,Peritoneal Neoplasms ,Cause of death ,LARYNGEAL-CANCER-MORTALITY ,RISK ,Ovarian Neoplasms ,Asbestosi ,Middle Aged ,peritoneum ,030210 environmental & occupational health ,Asbestos cement ,Occupational Diseases ,pleura ,Italy ,030220 oncology & carcinogenesis ,malignant mesothelioma ,Female ,Public Health ,Peritoneal Neoplasm ,FIBERS ,Carcinogen ,Cohort study ,Human ,Adult ,medicine.medical_specialty ,Pleural Neoplasms ,MODELS ,Socio-culturale ,Asbesto ,Asbestos ,Settore MED/01 - Statistica Medica ,CEMENT WORKERS ,03 medical and health sciences ,LUNG-CANCER ,asbestos ,occupational cancer ,ovary ,Internal medicine ,Occupational Exposure ,medicine ,Humans ,METAANALYSIS ,Aged ,LARYNGEAL-CANCER-MORTALITY, PLEURAL MESOTHELIOMA, TEXTILE WORKERS, LUNG-CANCER, FOLLOW-UP, CEMENT WORKERS,MODELS ,RISK, METAANALYSIS, FIBERS ,business.industry ,Construction Materials ,Ovarian Neoplasm ,Environmental and Occupational Health ,Mesothelioma, Malignant ,Ovary ,Public Health, Environmental and Occupational Health ,Ambientale ,medicine.disease ,Surgery ,Construction Material ,Lung Neoplasm ,Occupational Disease ,Carcinogens ,Cohort Studie ,FOLLOW-UP ,Ovarian cancer ,business - Abstract
Objective Asbestos is a known human carcinogen, with evidence for malignant mesothelioma (MM), cancers of lung, ovary, larynx and possibly other organs. MM rates are predicted to increase with a power of time since first exposure (TSFE), but the possible long-term attenuation of the trend is debated. The asbestos ban enforced in Italy in 1992 gives an opportunity to measure long-term cancer risk in formerly exposed workers. Methods Pool of 43 previously studied Italian asbestos cohorts (asbestos cement, rolling stock, shipbuilding), with mortality follow-up updated to 2010. SMRs were computed for the 1970–2010 period, for the major causes, with consideration of duration and TSFE, using reference rates by age, sex, region and calendar period. Results The study included 51 801 subjects (5741 women): 55.9% alive, 42.6% died (cause known for 95%) and 1.5% lost to follow-up. Mortality was significantly increased for all deaths (SMR: men: 1.05, 95% CI 1.03 to 1.06; women: 1.17, 95% CI to 1.12 to 1.22), all malignancies combined (SMR: men: 1.17, 95% CI to 1.14 to 1.20; women: 1.33, 95% CI 1.24 to 1.43), pleural and peritoneal malignancies (SMR: men: 13.28 and 4.77, 95% CI 12.24 to 14.37 and 4.00 to 5.64; women: 28.44 and 6.75, 95% CI 23.83 to 33.69 and 4.70 to 9.39), lung (SMR: men: 1.26, 95% CI 1.21 to 1.31; women: 1.43, 95% CI 1.13 to 1.78) and ovarian cancer (SMR=1.38, 95% CI 1.00 to 1.87) and asbestosis (SMR: men: 300.7, 95% CI 270.7 to 333.2; women: 389.6, 95% CI 290.1 to 512.3). Pleural cancer rate increased during the first 40 years of TSFE and reached a plateau after. Discussion The study confirmed the increased risk for cancer of the lung, ovary, pleura and peritoneum but not of the larynx and the digestive tract. Pleural cancer mortality reached a plateau at long TSFE, coherently with recent reports.
- Published
- 2017