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1,023 results on '"Vendrell J"'

3. P074 Inflammatory Environment-Induced Transcriptomic Alterations in Crohn's Disease Adipose Stem Cells

Author

Montfort-Ferré, D, primary, Boronat-Toscano, A, additional, Sánchez-Herrero, J F, additional, Caro, A, additional, Menacho, M, additional, Vañó-Segarra, I, additional, Martí, M, additional, Espina, B, additional, Pluvinet, R, additional, Cabrinety, L, additional, Abadia, C, additional, Ejarque, M, additional, Nuñez-Roa, C, additional, Maymo-Masip, E, additional, Sumoy, L, additional, Vendrell, J, additional, Fernández-Veledo, S, additional, and Serena, C, additional

Published
2024
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5. Fatty liver index as a predictor for type 2 diabetes in subjects with normoglycemia in a nationwide cohort study

Author

García-Escobar, E., Valdés, S., Soriguer, F., Vendrell, J., Urrutia-Etxebarria, I. M., Maldonado-Araque, C., Ortega, E., Ocón, P., Montanya, E., Menéndez, E., Lago-Sampedro, A., González-Frutos, T., Gomis, R., Goday, A., García-Serrano, S., Galán-García, J. L., Castell, C., Bordiú, E., Badía, R., Aguilera-Venegas, G., Girbés, J., Gaztambide, S., Delgado, E., Chaves, F. J., Castaño, L., Calle-Pascual, A., Rojo-Martínez, G., and Franch-Nadal, J.

Published
2021
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6. Incidence of diabetes mellitus in Spain as results of the nation-wide cohort di@bet.es study

Author

Rojo-Martínez, G., Valdés, S., Soriguer, F., Vendrell, J., Urrutia, I., Pérez, V., Ortega, E., Ocón, P., Montanya, E., Menéndez, E., Lago-Sampedro, A., González- Frutos, T., Gomis, R., Goday, A., García-Serrano, S., García-Escobar, E., Galán-García, J. L., Castell, C., Badía-Guillén, R., Aguilera-Venegas, G., Girbés, J., Gaztambide, S., Franch-Nadal, J., Delgado, E., Chaves, F. J., Castaño, L., and Calle-Pascual, A.

Published
2020
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12. Mediterranean Diet Adherence in Individuals with Prediabetes and Unknown Diabetes : The Di@bet.es Study

Author

Ortega, E., Franch, J., Castell, C., Goday, A., Ribas-Barba, L., Soriguer, F., Vendrell, J., Casamitjana, R., Bosch-Comas, A., Bordiú, E., Calle-Pascual, A., Carmena, R., Castaño, L., Catalá, M., Delgado, E., Gaztambide, S., Girbés, J., López-Alba, A., Martínez-Larrad, M.T., Menéndez, E., Mora-Peces, I., Pascual-Manich, G., Rojo-Martínez, G., Serrano-Rios, M., Urrutía, I., Valdés, S., Vázquez, J. A., and Gomis, R.

Published
2013

13. Iodine intake in the adult population. Di@bet.es study

Author

Soriguer, F., García-Fuentes, E., Gutierrez-Repiso, C., Rojo-Martínez, G., Velasco, I., Goday, A., Bosch-Comas, A., Bordiú, E., Calle, A., Carmena, R., Casamitjana, R., Castaño, L., Castell, C., Catalá, M., Delgado, E., Franch, J., Gaztambide, S., Girbés, J., Gomis, R., Gutiérrez, G., López-Alba, A., Martínez-Larrad, M.T., Menéndez, E., Mora-Peces, I., Ortega, E., Pascual-Manich, G., Serrano-Rios, M., Valdés, S., Vázquez, J.A., and Vendrell, J.

Published
2012
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16. Role of Gastrointestinal Hormones as a Predictive Factor for Long-Term Diabetes Remission: Randomized Trial Comparing Metabolic Gastric Bypass, Sleeve Gastrectomy, and Greater Curvature Plication

Author

Casajoana, A, Guerrero-Perez, F, de Gordejuela, AGR, Admella, V, Sorribas, M, Vidal-Alabro, A, Virgili, N, Urdiales, RL, Montserrat, M, Perez-Maraver, M, Monasterio, C, Salord, N, Pellitero, S, Fernandez-Veledo, S, Vendrell, J, Gebelli, JP, and Vilarrasa, N

Subjects
Bariatric surgery, Type 2 diabetes mellitus, Obesity, Metabolic gastric bypass, Sleeve, Diabetes remission, Greater curvature plication
Abstract

Purpose Long-term studies comparing the mechanisms of different bariatric techniques for T2DM remission are scarce. We aimed to compare type 2 diabetes (T2DM) remission after a gastric bypass with a 200-cm biliopancreatic limb (mRYGB), sleeve gastrectomy (SG), and greater curvature plication (GCP), and to assess if the initial secretion of gastrointestinal hormones may predict metabolic outcomes at 5 years. Material and Methods Forty-five patients with mean BMI of 39.4(1.9)kg/m(2) and T2DM with HbA(1c) of 7.7(1.9)% were randomized to mRYGB, SG, or GCP. Anthropometric and biochemical parameters, fasting concentrations of PYY, ghrelin, glucagon, and AUC of GLP-1 after SMT were determined prior to and at months 1 and 12 after surgery. At 5-year follow-up, anthropometrical and biochemical parameters were determined. Results Total weight loss percentage (TWL%) at year 1 and GLP-1 AUC at months 1 and 12 were higher in the mRYGB than in the SG and GCP. TWL% remained greater at 5 years in mRYGB group - 27.32 (7.8) vs. SG - 18.00 (10.6) and GCP - 14.83 (7.8), p = 0.001. At 5 years, complete T2DM remission was observed in 46.7% after mRYGB vs. 20.0% after SG and 6.6% after GCP, p < 0.001. In the multivariate analysis, shorter T2DM duration (OR 0.186), p = 0.008, and the GLP-1 AUC at 1 month (OR 7.229), p = 0.023, were prognostic factors for complete T2DM remission at 5-year follow-up. Conclusions Long-term T2DM remission is mostly achieved with hypoabsortive techniques such as mRYGB. Increased secretion of GLP-1 after surgery and shorter disease duration were the main predictors of T2DM remission at 5 years.

Published
2021

17. Olive oil has a beneficial effect on impaired glucose regulation and other cardiometabolic risk factors. Di@bet.es study

Author

Soriguer, F., Rojo-Martinez, G., Goday, A., Bosch-Comas, A., Bordiu, E., Caballero-Diaz, F., Calle-Pascual, A., Carmena, R., Casamitjana, R., Castano, L., Castell, C., Catala, M., Delgado, E., Franch, J., Gaztambide, S., Girbes, J., Gomis, R., Gutierrez, G., Lopez-Alba, A., Martinez-Larrad, M. Teresa, Menendez, E., Mora-Peces, I., Ortega, E., Pascual-Manich, G., Serrano-Rios, M., Urrutia, I., Valdes, S., Vazquez, J. Antonio, and Vendrell, J.

Subjects
Olive oil -- Health aspects, Diabetes -- Physiological aspects -- Risk factors, Glucose metabolism -- Research, Food/cooking/nutrition, Health
Abstract

BACKGROUND: Despite the marked increase in cardiovascular risk factors in Spain in recent years, the prevalence and incidence of cardiovascular diseases have not risen as expected. Our objective is to examine the association between consumption of olive oil and the presence of cardiometabolic risk factors in the context of a large study representative of the Spanish population. SUBJECTS AND METHODS: A population-based, cross-sectional, cluster sampling study was conducted. The target population was the whole Spanish population. A total of 4572 individuals aged ≥ 18 years in 100 clusters (health centers) were randomly selected with a probability proportional to population size. The main outcome measures were clinical and demographic structured survey, lifestyle survey, physical examination (weight, height, body mass index, waist, hip and blood pressure) and oral glucose tolerance test (OGTT) (75 g). RESULTS: Around 90% of the Spanish population use olive oil, at least for dressing, and slightly fewer for cooking or frying. The preference for olive oil is related to age, educational level, alcohol intake, body mass index and serum glucose, insulin and lipids. People who consume olive oil (vs sunflower oil) had a lower risk of obesity (odds ratio (OR) = 0.62 (95% confidence interval (CI) = 0.41-0.93, P = 0.02)), impaired glucose regulation (OR = 0.49 (95% CI = 0.28-0.86, P = 0.04)), hypertriglyceridemia (OR = 0.53 (95% CI = 0.33-0.84, P = 0.03)) and low HDL cholesterol levels (OR = 0.40 (95% CI = 0.26-0.59, P = 0.0001)). CONCLUSIONS: The results show that consumption of olive oil has a beneficial effect on different cardiovascular risk factors, particularly in the presence of obesity, impaired glucose tolerance or a sedentary lifestyle. European Journal of Clinical Nutrition (2013) 67, 911-916; doi:10.1038/ejcn.2013.130; published online 17 July 2013 Keywords: olive oil; diabetes; impaired glucose regulation; obesity; population-based study; cardiovascular risk, INTRODUCTION The high rates of morbidity and mortality due to cardiovascular diseases represent one of the greatest social and health care problems in developed countries, as well as in many [...]

Published
2013
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23. Prevalence of diabetes mellitus and impaired glucose regulation in Spain: the Di@bet.es Study

Author

Soriguer, F., Goday, A., Bosch-Comas, A., Bordiú, E., Calle-Pascual, A., Carmena, R., Casamitjana, R., Castaño, L., Castell, C., Catalá, M., Delgado, E., Franch, J., Gaztambide, S., Girbés, J., Gomis, R., Gutiérrez, G., López-Alba, A., Martínez-Larrad, M. T., Menéndez, E., Mora-Peces, I., Ortega, E., Pascual-Manich, G., Rojo-Martínez, G., Serrano-Rios, M., Valdés, S., Vázquez, J. A., and Vendrell, J.

Published
2012
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28. Adipose stem cells from patients with Crohn's disease show a distinctive DNA methylation pattern

Author

Serena, C, Millan, M, Ejarque, M, Saera-Vila, A, Maymo-Masip, E, Nunez-Roa, C, Monfort-Ferre, D, Terron-Puig, M, Bautista, M, Menacho, M, Marti, M, Espin, E, Vendrell, J, and Fernandez-Veledo, S

Subjects
Adipose tissue, Methylome, Epigenetics, Gene expression, Inflammatory bowel disease
Abstract

Background Crohn's disease (CD) is characterized by persistent inflammation and ulceration of the small or large bowel, and expansion of mesenteric adipose tissue, termed creeping fat (CF). We previously demonstrated that human adipose-derived stem cells (hASCs) from CF of patients with CD exhibit dysfunctional phenotypes, including a pro-inflammatory profile, high phagocytic capacity, and weak immunosuppressive properties. Importantly, these phenotypes persist in patients in remission and are found in all adipose depots explored including subcutaneous fat. We hypothesized that changes in hASCs are a consequence of epigenetic modifications. Methods We applied epigenome-wide profiling with a methylation array (Illumina EPIC/850k array) and gene expression analysis to explore the impact of CD on the methylation signature of hASCs isolated from the subcutaneous fat of patients with CD and healthy controls (n = 7 and 5, respectively; cohort I). Differentially methylated positions (p value cutoff < 1 x 10(-4) and ten or more DMPs per gene) and regions (inclusion threshold 0.2, p value cutoff < 1 x 10(-2) and more than 2 DMRs per gene) were identified using dmpfinder and Bumphunter (minfi), respectively. Changes in the expression of differentially methylated genes in hASCs were validated in a second cohort (n = 10/10 inactive and active CD and 10 controls; including patients from cohort I) and also in peripheral blood mononuclear cells (PBMCs) of patients with active/inactive CD and of healthy controls (cohort III; n = 30 independent subjects). Results We found a distinct DNA methylation landscape in hASCs from patients with CD, leading to changes in the expression of differentially methylated genes involved in immune response, metabolic, cell differentiation, and development processes. Notably, the expression of several of these genes in hASCs and PBMCs such as tumor necrosis factor alpha (TNFA) and PR domain zinc finger protein 16 (PRDM16) were not restored to normal (healthy) levels after disease remission. Conclusions hASCs of patients with CD exhibit a unique DNA methylation and gene expression profile, but the expression of several genes are only partially restored in patients with inactive CD, both in hASCs and PBMCs. Understanding how CD shapes the functionality of hASCs is critical for investigating the complex pathophysiology of this disease, as well as for the success of cell-based therapies.

Published
2020

29. Impaired Succinate Response to a Mixed Meal in Obesity and Type 2 Diabetes Is Normalized After Metabolic Surgery

Author

Astiarraga B, Martínez L, Ceperuelo-Mallafré V, Llauradó G, Terrón-Puig M, Mar Rodríguez M, Casajoana A, Pellitero S, Megía A, Vilarrasa N, Vendrell J, and Fernández-Veledo S

Abstract

To explore the meal response of circulating succinate in patients with obesity and type 2 diabetes undergoing bariatric surgery and to examine the role of gastrointestinal glucose sensing in succinate dynamics in healthy subjects.

Published
2020

42. Malignancy after Augmentation Enterocystoplasty: A Nationwide Study of Natural History, Prognosis and Oncogene Panel Analysis

Author

Garnier, S., primary, Vendrell, J., additional, Boillot, B., additional, Karsenty, G., additional, Faure, A., additional, Blanc, T., additional, Soustelle, L., additional, Phe, V., additional, Even, A., additional, Chartier-Kastler, E., additional, Ravasse, P., additional, Poinas, G., additional, Leizour, B., additional, Costa, P., additional, Galmiche, L., additional, Iborra, F., additional, Bouali, O., additional, Game, X., additional, Solassol, J., additional, and Kalfa, N., additional

Published
2020
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50. Synthesis and Structural/Functional Characterization of Selective M14 Metallocarboxypeptidase Inhibitors Based on Phosphinic Pseudopeptide Scaffold: Implications on the Design of Specific Optical Probes

Author

Covaleda, G. Gallego, P. Vendrell, J. Georgiadis, D. Lorenzo, J. Dive, V. Aviles, F.X. Reverter, D. Devel, L.

Abstract

Metallocarboxypeptidases (MCPs) of the M14 family are Zn 2+ -dependent exoproteases present in almost every tissue or fluid in mammals. These enzymes perform a large variety of physiological functions and are involved in several pathologies, such as pancreatic diseases, inflammation, fibrinolysis, and cancer. Here, we describe the synthesis and functional/structural characterization of a series of reversible tight-binding phosphinic pseudopeptide inhibitors that show high specificity and potency toward these proteases. Characterization of their inhibitory potential against a large variety of MCPs, combined with high-resolution crystal structures of three selected candidates in complex with human carboxypeptidase A (CPA)1, allowed to decipher the structural determinants governing selectivity for type-A of the M14A MCP family. Further, the phosphinic pseudopeptide framework was exploited to generate an optical probe selectively targeting human CPAs. The phosphinic pseudopeptides presented here constitute the first example of chemical probes useful to selectively report on type-A MCPs activity in complex media. © 2019 American Chemical Society.

Published
2019

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