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13 results on '"Vendeville, Cathy"'

1. The effect of camelina oil on vascular function in essential hypertensive patients with metabolic syndrome: a randomized, placebo-controlled, double-blind study

Author

Bellien, Jeremy, Bozec, Erwan, Bounoure, Frédéric, Khettab, Hakim, Malloizel-Delaunay, Julie, Skiba, Mohamed, Iacob, Michèle, Donnadieu, Nathalie, Coquard, Aude, Morio, Béatrice, Laillet, Brigitte, Rigaudière, Jean-Paul, Chardigny, Jean-Michel, Monteil, Christelle, Vendeville, Cathy, Mercier, Alain, Cailleux, Anne-Françoise, Blanchard, Anne, Amar, Jacques, Fezeu, Léopold K, Pannier, Bruno, Bura-Rivière, Alessandra, Boutouyrie, Pierre, and Joannidès, Robinson

Published
2022
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5. Nitrogen Dioxide Inhalation Exposures Induce Cardiac Mitochondrial Reactive Oxygen Species Production, Impair Mitochondrial Function and Promote Coronary Endothelial Dysfunction

Author

Karoui, Ahmed, primary, Crochemore, Clément, additional, Harouki, Najah, additional, Corbière, Cécile, additional, Preterre, David, additional, Vendeville, Cathy, additional, Richard, Vincent, additional, Fardel, Olivier, additional, Lecureur, Valérie, additional, Vaugeois, Jean-Marie, additional, Sichel, François, additional, Mulder, Paul, additional, and Monteil, Christelle, additional

Published
2020
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6. Cover Image

Author

Lachaux, Marianne, primary, Soulié, Matthieu, additional, Hamzaoui, Mouad, additional, Bailly, Anaëlle, additional, Nicol, Lionel, additional, Rémy‐Jouet, Isabelle, additional, Renet, Sylvanie, additional, Vendeville, Cathy, additional, Gluais‐Dagorn, Pascale, additional, Hallakou‐Bozec, Sophie, additional, Monteil, Christelle, additional, Richard, Vincent, additional, and Mulder, Paul, additional

Published
2020
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7. Short‐and long‐term administration of imeglimin counters cardiorenal dysfunction in a rat model of metabolic syndrome

Author

Lachaux, Marianne, primary, Soulié, Matthieu, additional, Hamzaoui, Mouad, additional, Bailly, Anaëlle, additional, Nicol, Lionel, additional, Rémy‐Jouet, Isabelle, additional, Renet, Sylvanie, additional, Vendeville, Cathy, additional, Gluais‐Dagorn, Pascale, additional, Hallakou‐Bozec, Sophie, additional, Monteil, Christelle, additional, Richard, Vincent, additional, and Mulder, Paul, additional

Published
2020
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8. effect of camelina oil on vascular function in essential hypertensive patients with metabolic syndrome: a randomized, placebo-controlled, double-blind study.

Author

Bellien, Jeremy, Bozec, Erwan, Bounoure, Frédéric, Khettab, Hakim, Malloizel-Delaunay, Julie, Skiba, Mohamed, Iacob, Michèle, Donnadieu, Nathalie, Coquard, Aude, Morio, Béatrice, Laillet, Brigitte, Rigaudière, Jean-Paul, Chardigny, Jean-Michel, Monteil, Christelle, Vendeville, Cathy, Mercier, Alain, Cailleux, Anne-Françoise, Blanchard, Anne, Amar, Jacques, and Fezeu, Léopold K

Subjects
HYPERTENSION, C-reactive protein, CARDIOVASCULAR system physiology, CAROTID intima-media thickness, VEGETABLE oils, ANTHROPOMETRY, HEALTH outcome assessment, RANDOMIZED controlled trials, PLACEBOS, INSULIN, ARTERIAL diseases, COMPARATIVE studies, OXIDATIVE stress, TREATMENT effectiveness, METABOLIC syndrome, BLIND experiment, ESSENTIAL hypertension, DESCRIPTIVE statistics, STATISTICAL sampling, LIPIDS, CREATININE, FATTY acids, EVALUATION
Abstract

Background The effects of a dietary supplementation with the vegetable ω-3 α-linolenic acid (ALA) on cardiovascular homeostasis are unclear. In this context, it would be interesting to assess the effects of camelina oil. Objective This study aimed to assess the cardiovascular and metabolic effects of camelina oil in hypertensive patients with metabolic syndrome. Methods In a double-blind, placebo-controlled randomized study, treated essential hypertensive patients with metabolic syndrome received, during 6 mo, either cyclodextrin-complexed camelina oil containing ≈ 1.5 g ALA/d (n  = 40) or an isocaloric placebo (n  = 41), consisting of the same quantity of cyclodextrins and wheat starch. Anthropometric data, plasma lipids, glycemia, insulinemia, creatininemia, TBARs, high-sensitivity C-reactive protein, and n–3, n–6, and n–9 fatty acids in erythrocyte membranes were measured. Peripheral and central blood pressures, arterial stiffness, carotid intima-media thickness, and brachial artery endothelium-dependent flow-mediated dilatation (FMD) and endothelium-independent dilatation were assessed. Results Compared with placebo, camelina oil increased ALA (mean ± SD: 0 ± 0.04 compared with 0.08 ± 0.06%, P  <0.001), its elongation product EPA (0 ± 0.5 compared with 0.16 ± 0.65%, P  <0.05), and the n–9 gondoic acid (GA; 0 ± 0.04 compared with 0.08 ± 0.04%, P  <0.001). No between-group difference was observed for cardiovascular parameters. However, changes in FMD were associated with the magnitude of changes in EPA (r = 0.26, P  = 0.03). Compared with placebo, camelina oil increased fasting glycemia (–0.2 ± 0.6 compared with 0.3 ± 0.5 mmol/L, P  <0.001) and HOMA-IR index (–0.8 ± 2.5 compared with 0.5 ± 0.9, P  <0.01), without affecting plasma lipids, or inflammatory and oxidative stress markers. Changes in HOMA-IR index were correlated with the magnitude of changes in GA (r = 0.32, P  <0.01). Nutritional intake remained similar between groups. Conclusion ALA supplementation with camelina oil did not improve vascular function but adversely affected glucose metabolism in hypertensive patients with metabolic syndrome. Whether this adverse effect on insulin sensitivity is related to GA enrichment, remains to be elucidated. [ABSTRACT FROM AUTHOR]

Published
2022
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9. Comparative study of diesel and biodiesel exhausts repeated exposure on lung genotoxicity in rats

Author

Douki, Thierry, Corbière, Cécile, Preterre, David, Martin, Perrine, Lecureur, Valérie, Andre, Veronique, Landkocz, Yann, Pottier, Ivannah, Véronika, Keravec, Fardel, Olivier, Silvestre, Moreila-Rebelo, Pottier, Didier, Vendeville, Cathy, Dionnet, Frédéric, Gosset, Pierre, Billet, Sylvain, Monteil, Christelle, Sichel, François, Chimie Interface Biologie pour l’Environnement, la Santé et la Toxicologie (CIBEST ), SYstèmes Moléculaires et nanoMatériaux pour l’Energie et la Santé (SYMMES), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Département Interfaces pour l'énergie, la Santé et l'Environnement (DIESE), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Aliments Bioprocédés Toxicologie Environnements (ABTE), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Centre d'Etude et de Recherche Technologique en Aérothermique et Moteurs [Saint Etienne du Rouvray] (CERTAM), Unité de Chimie Environnementale et Interactions sur le Vivant (UCEIV), Université du Littoral Côte d'Opale (ULCO), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN), Université de Rouen Normandie (UNIROUEN), Institut de Chimie du CNRS (INC)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU), and POTTIER, Ivannah

Subjects
[SDE] Environmental Sciences, [SDV.TOX] Life Sciences [q-bio]/Toxicology, [SDV.CAN] Life Sciences [q-bio]/Cancer, [SDV.TOX]Life Sciences [q-bio]/Toxicology, [SDE]Environmental Sciences, [SDV.CAN]Life Sciences [q-bio]/Cancer, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

10. Physiological role of endothelin-1 in flow-mediated vasodilatation in humans and impact of cardiovascular risk factors

Author

Bellien, Jérémy, primary, Iacob, Michèle, additional, Monteil, Christelle, additional, Rémy-Jouet, Isabelle, additional, Roche, Clothilde, additional, Duflot, Thomas, additional, Vendeville, Cathy, additional, Gutierrez, Laurence, additional, Thuillez, Christian, additional, Richard, Vincent, additional, and Joannidès, Robinson, additional

Published
2017
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11. Comparative mutagenicity and genotoxicity of particles and aerosols emitted by the combustion of standard vs. rapeseed methyl ester supplemented bio-diesel fuels: Impact of after treatment devices: Oxidation catalyst and particulate filter

Author

Andre, V., Barraud, Claire, Capron, David, Preterre, D., Keravec, V., Vendeville, Cathy, Cazier, F., Pottier, Didier, Morin, Jean-Paul, SICHEL, François, Aliments Bioprocédés Toxicologie Environnements (ABTE), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Centre d'Etude et de Recherche Technologique en Aérothermique et Moteurs [Saint Etienne du Rouvray] (CERTAM), Université de Rouen Normandie (UNIROUEN), Université du Littoral Côte d'Opale (ULCO), Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), and UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)

Subjects
Diesel exhaust, Mutagenicity, Aftertreatment devices, Particulate filter, [SDV.CAN]Life Sciences [q-bio]/Cancer, Genotoxicity, complex mixtures, Oxidation catalysis
Abstract

International audience; Diesel exhausts are partly responsible for the deleterious effects on human health associated with urban pollution, including cardiovascular diseases, asthma, COPD, and possibly lung cancer. Particulate fraction has been incriminated and thus largely investigated for its genotoxic properties, based on exposure conditions that are, however, not relevant for human risk assessment. In this paper, original and more realistic protocols were used to investigate the hazards induced by exhausts emitted by the combustion of standard (DF0) vs. bio-diesel fuels (DF7 and DF30) and to assess the impact of exhaust treatment devices (DOC and DPF). Mutagenicity and genotoxicity were evaluated for (1) resuspended particles (“off line” exposure that takes into account the bioavailability of adsorbed chemicals) and for (2) the whole aerosols (particles + gas phase components) under continuous flow exposure (“on line” exposure). Native particles displayed mutagenic properties associated with nitroaromatic profiles (YG1041), whereas PAHs did not seem to be involved. After DOC treatment, the mutagenicity of particles was fully abolished. In contrast, the level of particle deposition was low under continuous flow exposure, and the observed mutagenicity in TA98 and TA102 was thus attributable to the gas phase. A bactericidal effect was also observed in TA102 after DOC treatment, and a weak but significant mutagenicity persisted after DPF treatment for bio-diesel fuels. No formation of bulky DNA-adducts was observed on A549 cells exposed to diesel exhaust, even in very drastic conditions (organic extracts corresponding to 500 μg equivalent particule/mL, 48 h exposure). Taken together, these data indicate that the exhausts issued from the bio-diesel fuels supplemented with rapseed methyl ester (RME), and generated by current diesel engines equipped with after treatment devices are less mutagenic than older ones. The residual mutagenicity is linked to the gas phase and could be due to pro-oxydants, mainly for RME-supplemented fuels.

Published
2015
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12. Epoxyeicosatrienoic acids contribute with altered nitric oxide and endothelin-1 pathways to conduit artery endothelial dysfunction in essential hypertension

Author

Bellien, Jeremy, Iacob, Michele, Remy-Jouet, Isabelle, Lucas, Daniele, Monteil, Christelle, Gutierrez, Laurence, Vendeville, Cathy, Dreano, Yvonne, Mercier, Alain, Thuillez, Christian, Joannides, Robinson, Nouvelles Cibles Pharmacologiques de la Protection Endothéliale et de l'Insuffisance Cardiaque (EnVI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU), Pharmacie [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Génétique moléculaire et génétique épidémiologique, Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'Investigation Clinique [CHU Rouen] (CIC Rouen), Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Institut National de la Sante et de la Recherche Médicale-Direction de l'Hospitalisation et de l'Organisation des Soins for translational research and from the Société Française d'Hypertension Artérielle

Subjects
arteries, hypertension, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, cardiovascular system, epoxyeicosatrienoic acids, endothelium-derived factors
Abstract

International audience; BACKGROUND: We sought to clarify, using functional and biological approaches, the role of epoxyeicosatrienoic acids, nitric oxide (NO)/reactive oxygen species balance, and endothelin-1 in conduit artery endothelial dysfunction during essential hypertension. METHODS AND RESULTS: Radial artery diameter and mean wall shear stress were determined in 28 untreated patients with essential hypertension and 30 normotensive control subjects during endothelium-dependent flow-mediated dilatation induced by hand skin heating. The role of epoxyeicosatrienoic acids and NO was assessed with the brachial infusion of inhibitors of cytochrome P450 epoxygenases (fluconazole) and NO synthase (N(G)-monomethyl-l-arginine [L-NMMA]). Compared with controls, hypertensive patients exhibited a decreased flow-mediated dilatation in response to postischemic hyperemia as well as to heating, as shown by the lesser slope of their diameter-shear stress relationship. In controls, heating-induced flow-mediated dilatation was reduced by fluconazole, L-NMMA, and, to a larger extent, by L-NMMA+fluconazole. In patients, flow-mediated dilatation was not affected by fluconazole and was reduced by L-NMMA and L-NMMA+fluconazole to a lesser extent than in controls. Furthermore, local plasma epoxyeicosatrienoic acids increased during heating in controls (an effect diminished by fluconazole) but not in patients. Plasma nitrite, an indicator of NO availability, increased during heating in controls (an effect abolished by L-NMMA) and, to a lesser extent, in patients, whereas, inversely, reactive oxygen species increased more in patients (an effect diminished by L-NMMA). Plasma endothelin-1 decreased during heating in controls but not in patients. CONCLUSIONS: These results show that an impaired role of epoxyeicosatrienoic acids contributes, together with an alteration in NO/reactive oxygen species balance and endothelin-1 pathway, to conduit artery endothelial dysfunction in essential hypertension. CLINICAL TRIAL REGISTRATION: https://www.eudract.ema.europa.eu. Unique identifier: RCB2007-A001-10-53.

Published
2012
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