1. OS EFEITOS DAS METALOPROTEINASES DA MATRIZ EXTRACELULAR - MMPs E CLOREXIDINA NO MECANISMO DE ADESÃO DENTÁRIA.
- Author
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Formiga Medeiros, Ayala, Venâncio Avelar, Wellinton, Alípio da Silva Lima, Dayannara, Mirelly de Queiroz, Andreza, Campos, Fernanda, Gadelha Vasconcelos, Rodrigo, and Gadelha Vasconcelos, Marcelo
- Subjects
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DENTIN , *ADHESIVES , *PHOSPHORIC acid , *MONOMERS , *DENTAL glass ionomer cements - Abstract
The adhesion of the composite resin to the dentin occurs by the formation of the hybrid layer. Thus, its degradation causes loss of union resistance on interface resin / dentin interface, directly influencing the longevity of the restoration. After the acid etching and the application of the adhesive system into demineralized dentin, collagen fibers not involved by adhesive system get unprotected and susceptibles to attack by metalloproteinases (MMPs). The enzymes, present in the dentin itself, are rehabilitated by phosphoric acid or by the acids monomers of the self-etching adhesives initiating degradation. The application of chlorhexidine (CHX) in the dentin, after acid conditioning, prevents or slows down the degradation of the collagen fibers of the hybrid layer. This literature review sought to clarify the effect of MMPs on the degradation of the hybrid layer and the effects of chlorhexidine on the adhesion process. It was concluded that the adhesive bonding to dentin decreases with the passage of years due in part to the action of MMPs, which degrade collagen not infiltrated by adhesive monomers in the deepest part of the hybrid layer. In addition, the use of chlorhexidine as a therapeutic inhibitor in conventional adhesive systems is capable of inhibiting the MMPs and thus the adhesive bonding to the dentin can be kept stable for a longer period of time. [ABSTRACT FROM AUTHOR]
- Published
- 2019