Search

Your search keyword '"Veltman, Caroline E."' showing total 32 results
Start Over Author "Veltman, Caroline E."
32 results on '"Veltman, Caroline E."'

17. Comparative in vivo analysis of the atherosclerotic plaque targeting properties of eight human monoclonal antibodies

Author

Fiechter Michael, Frey Katharina, Fugmann Tim, Kaufmann Philipp A, Neri Dario, Veltman Caroline E, de Roos Albert, Pazhenkottil Aju, Kroft Lucia J, Boersma Eric, Herzog Bernhard, Leung Melissa, Maffei Erica, Leung Dominic Y, Cademartiri Filippo, Bax Jeroen J, Jukema J Wouter, University of Zurich, and Neri, D

Subjects
Male, Apolipoprotein E, Pathology, Apolipoprotein B, 030204 cardiovascular system & hematology, Iodine Radioisotopes, Mice, chemistry.chemical_compound, 0302 clinical medicine, Cricetinae, Fluorescence microscope, Fluorescein, Aorta, Mice, Knockout, 0303 health sciences, Antibodies, Monoclonal, Tenascin, 3. Good health, 10076 Center for Integrative Human Physiology, Antibody, Cardiology and Cardiovascular Medicine, Preclinical imaging, medicine.medical_specialty, medicine.drug_class, 610 Medicine & health, CHO Cells, Biology, Monoclonal antibody, 2705 Cardiology and Cardiovascular Medicine, 03 medical and health sciences, Apolipoproteins E, Cricetulus, Imaging, Three-Dimensional, In vivo, medicine, Animals, Humans, 030304 developmental biology, 10181 Clinic for Nuclear Medicine, Atherosclerosis, Matrix Metalloproteinases, Fibronectins, Mice, Inbred C57BL, Disease Models, Animal, HEK293 Cells, Microscopy, Fluorescence, chemistry, biology.protein, 570 Life sciences, biology, Autoradiography
Abstract

Objective The selective in vivo localization of antibody derivatives in atherosclerotic plaques may open novel diagnostic and therapeutic applications. Here, we present a comparative in vivo localization analysis of eight radioiodinated human monoclonal antibodies in apolipoprotein E-deficient (ApoE −/− ) mice. Methods Animals were fed with a cholesterol-rich diet, followed by harvesting of the aorta 24h after intravenous antibody injection and investigated by autoradiographic analysis. Localization of F8 antibody on atherosclerotic plaque structures was further studied in three-color fluorescence microscopy. Results The study revealed that the F8 antibody, specific to the alternatively spliced EDA domain of fibronectin, exhibited the highest plaque-targeting potential among the antibodies analyzed in this study, with an ability to preferentially localize to all plaques within the aorta. Targeting results were confirmed by injection of fluorescein-labeled F8 antibody, followed by three-color fluorescence microscopy analysis. Conclusion These findings open novel biomolecular avenues for the in vivo imaging of atherosclerotic plaques and for pharmacodelivery applications, since F8 had previously been reported by our group to strongly stain atherosclerotic plaques in human carotid arteries.

Published
2011
Full Text
View/download PDF

18. Prognosis of complete versus incomplete revascularisation of patients with STEMI with multivessel coronary artery disease: an observational study

Author

Dimitriu-Leen, Aukelien C, primary, Hermans, Maaike P J, additional, Veltman, Caroline E, additional, van der Hoeven, Bas L, additional, van Rosendael, Alexander R, additional, van Zwet, Erik W, additional, Schalij, Martin J, additional, Delgado, Victoria, additional, Bax, Jeroen J, additional, and Scholte, Arthur J H A, additional

Published
2017
Full Text
View/download PDF

19. Prognosis of complete versus incomplete revascularisation of patients with STEMI with multivessel coronary artery disease: an observational study.

Author

UCL - (SLuc) Service d'endocrinologie et de nutrition, Dimitriu-Leen, Aukelien C, Hermans, Michel, Veltman, Caroline E, van der Hoeven, Bas L, van Rosendael, Alexander R, van Zwet, Erik W, Schalij, Martin J, Delgado, Victoria, Bax, Jeroen J, Scholte, Arthur J H A, UCL - (SLuc) Service d'endocrinologie et de nutrition, Dimitriu-Leen, Aukelien C, Hermans, Michel, Veltman, Caroline E, van der Hoeven, Bas L, van Rosendael, Alexander R, van Zwet, Erik W, Schalij, Martin J, Delgado, Victoria, Bax, Jeroen J, and Scholte, Arthur J H A

Abstract

The best strategy in patients with acute ST-segment elevation myocardial infarction (STEMI) with multivessel coronary artery disease (CAD) regarding completeness of revascularisation of the non-culprit lesion(s) is still unclear. To establish which strategy should be followed, survival rates over a longer period should be evaluated. The aim of this study was to investigate whether complete revascularisation, compared with incomplete revascularisation, is associated with reduced short-term and long-term all-cause mortality in patients with first STEMI and multivessel CAD. This retrospective study consisted of 518 patients with first STEMI with multivessel CAD. Complete revascularisation (45%) was defined as the treatment of any significant coronary artery stenosis (≥70% luminal narrowing) during primary or staged percutaneous coronary intervention prior to discharge. The primary end point was all-cause mortality. Incomplete revascularisation was not independently associated with 30-day all-cause mortality in patients with acute first STEMI and multivessel CAD (OR 1.98; 95% CI 0.62to6.37; p=0.25). During a median long-term follow-up of 6.7 years, patients with STEMI with multivessel CAD and incomplete revascularisation showed higher mortality rates compared with patients who received complete revascularisation (24% vs 12%, p<0.001), and these differences remained after excluding the first 30 days. However, in multivariate analysis, incomplete revascularisation was not independently associated with increased all-cause mortality during long-term follow-up in the group of patients with STEMI who survived the first 30 days post-STEMI (HR 1.53 95% CI 0.89-2.61, p=0.12). In patients with acute first STEMI and multivessel CAD, incomplete revascularisation compared with complete revascularisation was not independently associated with increased short-term and long-term all-cause mortality.

Published
2017

20. Prognostic value of coronary vessel dominance in relation to significant coronary artery disease determined with non-invasive computed tomography coronary angiography

Author

Veltman, Caroline E., de Graaf, Fleur R., Schuijf, Joanne D., van Werkhoven, Jacob M., Jukema, J. Wouter, Kaufmann, Philipp A., Pazhenkottil, Aju P., Kroft, Lucia J., Boersma, Eric, Bax, Jeroen J., Schalij, Martin J., van der Wall, Ernst E., Veltman, Caroline E., de Graaf, Fleur R., Schuijf, Joanne D., van Werkhoven, Jacob M., Jukema, J. Wouter, Kaufmann, Philipp A., Pazhenkottil, Aju P., Kroft, Lucia J., Boersma, Eric, Bax, Jeroen J., Schalij, Martin J., and van der Wall, Ernst E.

Abstract

Aims Limited information is available regarding the relationship between coronary vessel dominance and prognosis. Therefore, the purpose of this study was to determine the prognostic value of coronary vessel dominance in relation to significant coronary artery disease (CAD) in patients referred for computed tomography coronary angiography (CTA). Methods and results The study population consisted of 1425 patients (869 men, 57 ± 12 years) referred for CTA. To evaluate the impact of vessel dominance and significant CAD on CTA on outcome, patients were followed during a median period of 24 months for the occurrence of non-fatal myocardial infarction and all-cause mortality. The presence of a left dominant system was identified as a significant predictor for non-fatal myocardial infarction and all-cause mortality (HR: 3.20; 95% CI: 1.67-6.13, P < 0.001) and had incremental value over baseline risk factors and severity of CAD on CTA. In addition, in the subgroup of patients with significant CAD on CTA, patients with a left dominant system had a worse outcome compared with patients with a right dominant system (cumulative event rates: 9.5% and 35% at 3-year follow-up for a right and left dominant coronary artery system, respectively, log-rank P < 0.001). Conclusions The presence of a left dominant system was identified as an independent predictor of non-fatal myocardial infarction and all-cause mortality, especially in patients with significant CAD on CTA. Therefore, the assessment of coronary vessel dominance on CTA may further enhance risk stratification beyond the assessment of significant CAD on CTA

Published
2017

22. Prognostic value of coronary vessel dominance in relation to significant coronary artery disease determined with non-invasive computed tomography coronary angiography

Author

Veltman, Caroline E, de Graaf, Fleur R, Schuijf, Joanne D, van Werkhoven, Jacob M, Jukema, J Wouter, Kaufmann, Philipp A, Pazhenkottil, Aju P, Kroft, Lucia J, Boersma, Eric, Bax, Jeroen J, Schalij, Martin J, van der Wall, Ernst E, Veltman, Caroline E, de Graaf, Fleur R, Schuijf, Joanne D, van Werkhoven, Jacob M, Jukema, J Wouter, Kaufmann, Philipp A, Pazhenkottil, Aju P, Kroft, Lucia J, Boersma, Eric, Bax, Jeroen J, Schalij, Martin J, and van der Wall, Ernst E

Abstract

AIMS: Limited information is available regarding the relationship between coronary vessel dominance and prognosis. Therefore, the purpose of this study was to determine the prognostic value of coronary vessel dominance in relation to significant coronary artery disease (CAD) in patients referred for computed tomography coronary angiography (CTA). METHODS AND RESULTS: The study population consisted of 1425 patients (869 men, 57 ± 12 years) referred for CTA. To evaluate the impact of vessel dominance and significant CAD on CTA on outcome, patients were followed during a median period of 24 months for the occurrence of non-fatal myocardial infarction and all-cause mortality. The presence of a left dominant system was identified as a significant predictor for non-fatal myocardial infarction and all-cause mortality (HR: 3.20; 95% CI: 1.67-6.13, P < 0.001) and had incremental value over baseline risk factors and severity of CAD on CTA. In addition, in the subgroup of patients with significant CAD on CTA, patients with a left dominant system had a worse outcome compared with patients with a right dominant system (cumulative event rates: 9.5% and 35% at 3-year follow-up for a right and left dominant coronary artery system, respectively, log-rank P < 0.001). CONCLUSIONS: The presence of a left dominant system was identified as an independent predictor of non-fatal myocardial infarction and all-cause mortality, especially in patients with significant CAD on CTA. Therefore, the assessment of coronary vessel dominance on CTA may further enhance risk stratification beyond the assessment of significant CAD on CTA.

Published
2012

24. Age- and gender-specific differences in the prognostic value of CT coronary angiography

Author

Yiu, Kai Hang, primary, de Graaf, Fleur R, additional, Schuijf, Joanne D, additional, van Werkhoven, Jacob M, additional, Marsan, Nina Ajmone, additional, Veltman, Caroline E, additional, de Roos, Albert, additional, Pazhenkottil, Aju, additional, Kroft, Lucia J, additional, Boersma, Eric, additional, Herzog, Bernhard, additional, Leung, Melissa, additional, Maffei, Erica, additional, Leung, Dominic Y, additional, Kaufmann, Philipp A, additional, Cademartiri, Filippo, additional, Bax, Jeroen J, additional, and Jukema, J Wouter, additional

Published
2011
Full Text
View/download PDF

26. HEAD-TO-HEAD COMPARISON OF CALCIFICATION PATTERNS ON MULTIDETECTOR COMPUTED TOMOGRAPHY CORONARY ANGIOGRAPHY TO VULNERABLE PLAQUE CHARACTERISTICS ON VIRTUAL HISTOLOGY INTRAVASCULAR ULTRASOUND

Author

van Velzen, Joella E., primary, Schuijf, Joanne D., additional, de Graaf, Fleur R., additional, de Graaf, Michiel A., additional, Veltman, Caroline E., additional, Schalij, Martin J., additional, Kroft, Lucia J., additional, de Roos, Albert, additional, Reiber, Johannes HC, additional, Jukema, J. Wouter, additional, van der Wall, Ernst E., additional, and Bax, Jeroen J., additional

Published
2011
Full Text
View/download PDF

27. Independent Susceptibility Markers for Atrial Fibrillation on Chromosome 4q25

Author

Lubitz, Steven A., primary, Sinner, Moritz F., additional, Lunetta, Kathryn L., additional, Makino, Seiko, additional, Pfeufer, Arne, additional, Rahman, Rosanna, additional, Veltman, Caroline E., additional, Barnard, John, additional, Bis, Joshua C., additional, Danik, Stephan P., additional, Sonni, Akshata, additional, Shea, Marisa A., additional, del Monte, Federica, additional, Perz, Siegfried, additional, Müller, Martina, additional, Peters, Annette, additional, Greenberg, Steven M., additional, Furie, Karen L., additional, van Noord, Charlotte, additional, Boerwinkle, Eric, additional, Stricker, Bruno H.C., additional, Witteman, Jacqueline, additional, Smith, Jonathan D., additional, Chung, Mina K., additional, Heckbert, Susan R., additional, Benjamin, Emelia J., additional, Rosand, Jonathan, additional, Arking, Dan E., additional, Alonso, Alvaro, additional, Kääb, Stefan, additional, and Ellinor, Patrick T., additional

Published
2010
Full Text
View/download PDF

28. For what endpoint does myocardial 123I-MIBG scintigraphy have the greatest prognostic value in patients with chronic heart failure? Results of a pooled individual patient data meta-analysis.

Author

Verschure, Derk O., Veltman, Caroline E., Manrique, Alain, Somsen, G. Aernout, Koutelou, Maria, Katsikis, Athanasios, Agostini, Denis, Gerson, Myron C., van Eck-Smit, Berthe L. F., Scholte, Arthur J. H. A., Jacobson, Arnold F., and Verberne, Hein J.

Subjects
CHEST disease diagnosis, DIAGNOSIS of diabetes, HEART anatomy, HEART disease related mortality, HEART failure, HYPERTENSION, CARDIOVASCULAR disease diagnosis, CARDIOMYOPATHIES, MEDIASTINUM diseases, ADRENERGIC beta agonists, ALDOSTERONE antagonists, AMIODARONE, ACE inhibitors, CARDIAC output, CARDIOLOGY, CHI-squared test, CHRONIC diseases, CONFIDENCE intervals, DIAGNOSTIC imaging, HEART diseases, HEART transplantation, HEART beat, ISCHEMIA, EVALUATION of medical care, META-analysis, RADIONUCLIDE imaging, SYMPATHETIC nervous system, TRANSPLANTATION of organs, tissues, etc., COMORBIDITY, DATA analysis, ACQUISITION of data, PROPORTIONAL hazards models, PATIENT selection, DIAGNOSIS
Abstract

The article presents a research study which aims to determine the prognostic value of myocardial 123I-metaiodobenzylguanidine (MIBG) scintigraphy in patients suffering with chronic heart failure (CHF). It states that the majority of individuals in the research study were male, and had decreased left ventricular ejection fraction. It concluded the importance of heart/mediastinum (H/M) ratio data for CHF patients.

Published
2014
Full Text
View/download PDF

29. Age- and gender-specific differences in the prognostic value of CT coronary angiography.

Author

Kai Hang Yiu, De Graaf, Fleur R., Schuijf, Joanne D, Van Werkhoven, Jacob M., Marsan, Nina Ajmone, Veltman, Caroline E., De Roos, Albert, Pazhenkottil, Aju, Kroft, Lucia J., Boersma, Eric, Herzog, Bernhard, Leung, Melissa, Maffei, Erica, Leung, Dominic Y., Kaufmann, Philipp A., Cademartiri, Filippo, Bax, Jeroen J., and Jukema, J. Wouter

Subjects
CORONARY arterial radiography, AGE factors in coronary heart disease, MYOCARDIAL infarction, TREATMENT effectiveness, CLINICAL trials, PROGNOSIS
Abstract

Objective To evaluate the potential age- and gender-specific differences in the incidence and prognostic value of coronary artery disease (CAD) in patients undergoing CT coronary angiography (CTA). Design and patients In this multicentre prospective registry study, 2432 patients (mean age 57±12, 56% male) underwent CTA for suspected CAD. Patients were stratified into four groups according to age <60 or ≥60 years and, male or female gender. Main outcome measures A composite end point of cardiac death and non-fatal myocardial infarction. Results CTA results were normal in 991 (41%) patients, showed non-significant CAD in 761 (31%) patients and significant CAD in the remaining 680 (28%) patients. During follow-up (median 819 days, 25-75th centile 482-1142) a cardiovascular event occurred in 59 (2.4%) patients. The annualised event rate was 1.1% in the total population (men=1.3% and women=0.9%). In patients aged <60 years, the annualised event rate of male and female patients was 0.6% and 0.5%, respectively. Among patients aged ≥60 years the annualised event rate was 1.9% in male and 1.1% in female patients. Observations on CTA predicted events in male patients, both age <60 and ≥60 years and in female patients age ≥60 years (logrank test in all groups, p<0.01). However, CTA provided limited prognostic value in female patients aged <60 years (log-rank test, p=0.45). Conclusions After age and gender stratification, CTA findings were shown to be of limited predictive value in female patients aged <60 years as compared with male patients at any age and female patients aged ≥60 years. [ABSTRACT FROM AUTHOR]

Published
2012
Full Text
View/download PDF

30. Prognostic value of coronary vessel dominance in relation to significant coronary artery disease determined with non-invasive computed tomography coronary angiography

Author

Veltman, Caroline E., de Graaf, Fleur R., Schuijf, Joanne D., van Werkhoven, Jacob M., Jukema, J. Wouter, Kaufmann, Philipp A., Pazhenkottil, Aju P., Kroft, Lucia J., Boersma, Eric, Bax, Jeroen J., Schalij, Martin J., van der Wall, Ernst E., Veltman, Caroline E., de Graaf, Fleur R., Schuijf, Joanne D., van Werkhoven, Jacob M., Jukema, J. Wouter, Kaufmann, Philipp A., Pazhenkottil, Aju P., Kroft, Lucia J., Boersma, Eric, Bax, Jeroen J., Schalij, Martin J., and van der Wall, Ernst E.

Abstract

Aims Limited information is available regarding the relationship between coronary vessel dominance and prognosis. Therefore, the purpose of this study was to determine the prognostic value of coronary vessel dominance in relation to significant coronary artery disease (CAD) in patients referred for computed tomography coronary angiography (CTA). Methods and results The study population consisted of 1425 patients (869 men, 57 ± 12 years) referred for CTA. To evaluate the impact of vessel dominance and significant CAD on CTA on outcome, patients were followed during a median period of 24 months for the occurrence of non-fatal myocardial infarction and all-cause mortality. The presence of a left dominant system was identified as a significant predictor for non-fatal myocardial infarction and all-cause mortality (HR: 3.20; 95% CI: 1.67-6.13, P < 0.001) and had incremental value over baseline risk factors and severity of CAD on CTA. In addition, in the subgroup of patients with significant CAD on CTA, patients with a left dominant system had a worse outcome compared with patients with a right dominant system (cumulative event rates: 9.5% and 35% at 3-year follow-up for a right and left dominant coronary artery system, respectively, log-rank P < 0.001). Conclusions The presence of a left dominant system was identified as an independent predictor of non-fatal myocardial infarction and all-cause mortality, especially in patients with significant CAD on CTA. Therefore, the assessment of coronary vessel dominance on CTA may further enhance risk stratification beyond the assessment of significant CAD on CTA

31. Prognostic value of coronary vessel dominance in relation to significant coronary artery disease determined with non-invasive computed tomography coronary angiography

Author

Eric Boersma, Philipp A. Kaufmann, J. Wouter Jukema, Ernst E. van der Wall, Caroline E. Veltman, Joanne D. Schuijf, Jeroen J. Bax, Aju P. Pazhenkottil, Lucia J.M. Kroft, Jacob M. van Werkhoven, Martin J. Schalij, Fleur R. de Graaf, University of Zurich, Veltman, Caroline E, Epidemiology, and Cardiology

Subjects
Coronary angiography, Male, medicine.medical_specialty, Computed tomography, 610 Medicine & health, Kaplan-Meier Estimate, Coronary Angiography, Coronary artery disease, 2705 Cardiology and Cardiovascular Medicine, Computed tomography coronary angiography, Internal medicine, medicine, Humans, Myocardial infarction, Prospective Studies, cardiovascular diseases, Risk stratification, Dominance (genetics), Aged, medicine.diagnostic_test, business.industry, 10181 Clinic for Nuclear Medicine, Middle Aged, medicine.disease, Prognosis, Coronary Vessels, medicine.anatomical_structure, Coronary vessel, Cardiology, Population study, Coronary vessel dominance, Female, Radiology, Cardiology and Cardiovascular Medicine, business, Tomography, X-Ray Computed, Artery
Abstract

Aims Limited information is available regarding the relationship between coronary vessel dominance and prognosis. Therefore, the purpose of this study was to determine the prognostic value of coronary vessel dominance in relation to significant coronary artery disease (CAD) in patients referred for computed tomography coronary angiography (CTA). Methods and results The study population consisted of 1425 patients (869 men, 57 ± 12 years) referred for CTA. To evaluate the impact of vessel dominance and significant CAD on CTA on outcome, patients were followed during a median period of 24 months for the occurrence of non-fatal myocardial infarction and all-cause mortality. The presence of a left dominant system was identified as a significant predictor for non-fatal myocardial infarction and all-cause mortality (HR: 3.20; 95% CI: 1.67–6.13, P < 0.001) and had incremental value over baseline risk factors and severity of CAD on CTA. In addition, in the subgroup of patients with significant CAD on CTA, patients with a left dominant system had a worse outcome compared with patients with a right dominant system (cumulative event rates: 9.5% and 35% at 3-year follow-up for a right and left dominant coronary artery system, respectively, log-rank P < 0.001). Conclusions The presence of a left dominant system was identified as an independent predictor of non-fatal myocardial infarction and all-cause mortality, especially in patients with significant CAD on CTA. Therefore, the assessment of coronary vessel dominance on CTA may further enhance risk stratification beyond the assessment of significant CAD on CTA.

Published
2012

32. For what endpoint does myocardial 123I-MIBG scintigraphy have the greatest prognostic value in patients with chronic heart failure? Results of a pooled individual patient data meta-analysis.

Author

Verschure DO, Veltman CE, Manrique A, Somsen GA, Koutelou M, Katsikis A, Agostini D, Gerson MC, van Eck-Smit BL, Scholte AJ, Jacobson AF, and Verberne HJ

Subjects
3-Iodobenzylguanidine, Cause of Death, Chronic Disease, Endpoint Determination, Female, Heart Failure mortality, Humans, Male, Predictive Value of Tests, Prognosis, Radiopharmaceuticals, Risk Factors, Heart Failure diagnostic imaging, Tomography, Emission-Computed, Single-Photon
Abstract

Aims: The purpose of this study was to determine the most appropriate prognostic endpoint for myocardial (123)I-metaiodobenzylguanidine (MIBG) scintigraphy in patients with chronic heart failure (CHF) based on aggregate results from multiple studies published in the past decade., Methods and Results: Original individual late (3-5 h) heart/mediastinum (H/M) ratio data of 636 CHF patients were retrieved from six studies from Europe and the USA. All-cause mortality, cardiac mortality, arrhythmic events, and heart transplantation were investigated to determine which provided the strongest prognostic significance for the MIBG imaging data. The majority of patients was male (78%), had a decreased left ventricular ejection fraction (31.1 ± 12.5%), and a mean late H/M of 1.67 ± 0.47. During follow-up (mean 36.9 ± 20.1 months), there were 83 deaths, 67 cardiac deaths, 33 arrhythmic events, and 56 heart transplants. In univariate regression analysis, late H/M was a significant predictor of all event categories, but lowest hazard ratios (HRs) were for the composite endpoint of any event (HR = 0.30, 95% CI 0.19-0.46), all-cause (HR = 0.29, 95% CI 0.16-0.53), and cardiac mortality (HR = 0.28, 95% CI 0.14-0.55). In multivariate analysis, late H/M was an independent predictor for all event categories, except for arrhythmias., Conclusions: This pooled individual patient data meta-analysis showed that, in CHF patients, the late H/M ratio is not only useful as a dichotomous predictor of events (high vs. low risk), but also has prognostic implication over the full range of the outcome value for all event categories except arrhythmias., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2014. For permissions please email: journals.permissions@oup.com.)

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results