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3. Automatic Cerebral Vessel Extraction in TOF-MRA Using Deep Learning

Author

de Vos, V., Timmins, K. M., van der Schaaf, I. C., Ruigrok, Y., Velthuis, B. K., and Kuijf, H. J.

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning
Abstract

Deep learning approaches may help radiologists in the early diagnosis and timely treatment of cerebrovascular diseases. Accurate cerebral vessel segmentation of Time-of-Flight Magnetic Resonance Angiographs (TOF-MRAs) is an essential step in this process. This study investigates deep learning approaches for automatic, fast and accurate cerebrovascular segmentation for TOF-MRAs. The performance of several data augmentation and selection methods for training a 2D and 3D U-Net for vessel segmentation was investigated in five experiments: a) without augmentation, b) Gaussian blur, c) rotation and flipping, d) Gaussian blur, rotation and flipping and e) different input patch sizes. All experiments were performed by patch-training both a 2D and 3D U-Net and predicted on a test set of MRAs. Ground truth was manually defined using an interactive threshold and region growing method. The performance was evaluated using the Dice Similarity Coefficient (DSC), Modified Hausdorff Distance and Volumetric Similarity, between the predicted images and the interactively defined ground truth. The segmentation performance of all trained networks on the test set was found to be good, with DSC scores ranging from 0.72 to 0.83. Both the 2D and 3D U-Net had the best segmentation performance with Gaussian blur, rotation and flipping compared to other experiments without augmentation or only one of those augmentation techniques. Additionally, training on larger patches or slices gave optimal segmentation results. In conclusion, vessel segmentation can be optimally performed on TOF-MRAs using a trained 3D U-Net on larger patches, where data augmentation including Gaussian blur, rotation and flipping was performed on the training data., Comment: Preprint for the SPIE Medical Imaging, Image Processing Conference 2021

Published
2021

6. Mitral annular disjunction in idiopathic ventricular fibrillation patients: Just a bystander or a potential cause?

Author

Team Onderzoek, Team Medisch, Circulatory Health, Arts Assistenten Cardiologie, Researchgr. Hart-brein as., Brain, Verheul, L. M., Guglielmo, M., Groeneveld, S. A., Kirkels, F. P., Scrocco, C., Cramer, M. J., Bootsma, M., Kapel, G. F.L., Alings, M., Evertz, R., Mulder, B. A., Prakken, N. H.J., Balt, J. C., Volders, P. G.A., Hirsch, A., Yap, S. C., Postema, P. G., Nijveldt, R., Velthuis, B. K., Behr, E. R., Wilde, A. A.M., Hassink, R. J., Team Onderzoek, Team Medisch, Circulatory Health, Arts Assistenten Cardiologie, Researchgr. Hart-brein as., Brain, Verheul, L. M., Guglielmo, M., Groeneveld, S. A., Kirkels, F. P., Scrocco, C., Cramer, M. J., Bootsma, M., Kapel, G. F.L., Alings, M., Evertz, R., Mulder, B. A., Prakken, N. H.J., Balt, J. C., Volders, P. G.A., Hirsch, A., Yap, S. C., Postema, P. G., Nijveldt, R., Velthuis, B. K., Behr, E. R., Wilde, A. A.M., and Hassink, R. J.

Published
2024

7. Anatomical differences of intracranial arteries according to sex: a systematic review and meta-analysis

Author

Projectafdeling CVZ, Beeldverwerking ISI, Cancer, Researchgr. Hart-brein as., Brain, Circulatory Health, Neurologen, Ophelders, M. E.H., van Eldik, M. J.A., Vos, I. N., Beentjes, Y. S., Velthuis, B. K., Ruigrok, Y. M., Projectafdeling CVZ, Beeldverwerking ISI, Cancer, Researchgr. Hart-brein as., Brain, Circulatory Health, Neurologen, Ophelders, M. E.H., van Eldik, M. J.A., Vos, I. N., Beentjes, Y. S., Velthuis, B. K., and Ruigrok, Y. M.

Published
2024

8. Halved contrast medium dose coronary dual-layer CT-angiography – phantom study of tube current and patient characteristics

Author

Researchgr. Systems Radiology, Researchgr. Hart-brein as., Brain, Circulatory Health, MS Radiologie, Cancer, Infection & Immunity, Regenerative Medicine and Stem Cells, Kristiansen, C. H., Tetteroo, P. M., Dobrolinska, M. M., Lauritzen, P. M., Velthuis, B. K., Greuter, M. J.W., Suchá, D., de Jong, P. A., van der Werf, N. R., Researchgr. Systems Radiology, Researchgr. Hart-brein as., Brain, Circulatory Health, MS Radiologie, Cancer, Infection & Immunity, Regenerative Medicine and Stem Cells, Kristiansen, C. H., Tetteroo, P. M., Dobrolinska, M. M., Lauritzen, P. M., Velthuis, B. K., Greuter, M. J.W., Suchá, D., de Jong, P. A., and van der Werf, N. R.

Published
2024

9. Mitral annular disjunction in idiopathic ventricular fibrillation patients: just a bystander or a potential cause?

Author

Verheul, L M, Guglielmo, M, Groeneveld, S A, Kirkels, F P, Scrocco, C, Cramer, M J, Bootsma, M, Kapel, G F L, Alings, M, Evertz, R, Mulder, B A, Prakken, N H J, Balt, J C, Volders, P G A, Hirsch, A, Yap, S C, Postema, P G, Nijveldt, R, Velthuis, B K, and Behr, E R

Subjects
MITRAL valve, RESEARCH funding, VENTRICULAR fibrillation, MITRAL valve prolapse, RETROSPECTIVE studies, MAGNETIC resonance imaging, SYMPTOMS, DESCRIPTIVE statistics, ARRHYTHMIA, VENTRICULAR tachycardia, LONGITUDINAL method, VENTRICULAR arrhythmia, RESEARCH, IMPLANTABLE cardioverter-defibrillators
Abstract

Aims Previously, we demonstrated that inferolateral mitral annular disjunction (MAD) is more prevalent in patients with idiopathic ventricular fibrillation (IVF) than in healthy controls. In the present study, we advanced the insights into the prevalence and ventricular arrhythmogenicity by inferolateral MAD in an even larger IVF cohort. Methods and results This retrospective multi-centre study included 185 IVF patients [median age 39 (27, 52) years, 40% female]. Cardiac magnetic resonance images were analyzed for mitral valve and annular abnormalities and late gadolinium enhancement. Clinical characteristics were compared between patients with and without MAD. MAD in any of the 4 locations was present in 112 (61%) IVF patients and inferolateral MAD was identified in 24 (13%) IVF patients. Mitral valve prolapse (MVP) was found in 13 (7%) IVF patients. MVP was more prevalent in patients with inferolateral MAD compared with patients without inferolateral MAD (42 vs. 2%, P < 0.001). Pro-arrhythmic characteristics in terms of a high burden of premature ventricular complexes (PVCs) and non-sustained ventricular tachycardia (VT) were more prevalent in patients with inferolateral MAD compared to patients without inferolateral MAD (67 vs. 23%, P < 0.001 and 63 vs. 41%, P = 0.046, respectively). Appropriate implantable cardioverter defibrillator therapy during follow-up was comparable for IVF patients with or without inferolateral MAD (13 vs. 18%, P = 0.579). Conclusion A high prevalence of inferolateral MAD and MVP is a consistent finding in this large IVF cohort. The presence of inferolateral MAD is associated with a higher PVC burden and non-sustained VTs. Further research is needed to explain this potential interplay. [ABSTRACT FROM AUTHOR]

Published
2024
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11. The Influence Of Motion Compensated Reconstruction On Coronary Artery Analysis For A Dual-layer Detector Ct System: A Dynamic Phantom Study

Author

Tetteroo, P., primary, Dobrolinska, M., additional, Greuter, M., additional, van Hamersvelt, R., additional, Prakken, N., additional, Slart, R., additional, Vembar, M., additional, Grass, M., additional, Leiner, T., additional, Velthuis, B., additional, Suchá, D., additional, and van der Werf, N., additional

Published
2024
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13. Exploring the EVolution in PrognOstic CapabiLity of MUltisequence Cardiac MagneTIc ResOnance in PatieNts Affected by Takotsubo Cardiomyopathy Based on Machine Learning Analysis: Design and Rationale of the EVOLUTION Study

Author

Cau, R, Muscogiuri, G, Pisu, F, Gatti, M, Velthuis, B, Loewe, C, Cademartiri, F, Pontone, G, Montisci, R, Guglielmo, M, Sironi, S, Esposito, A, Francone, M, Dacher, N, Peebles, C, Bastarrika, G, Salgado, R, Saba, L, Cau R., Muscogiuri G., Pisu F., Gatti M., Velthuis B., Loewe C., Cademartiri F., Pontone G., Montisci R., Guglielmo M., Sironi S., Esposito A., Francone M., Dacher N., Peebles C., Bastarrika G., Salgado R., Saba L., Cau, R, Muscogiuri, G, Pisu, F, Gatti, M, Velthuis, B, Loewe, C, Cademartiri, F, Pontone, G, Montisci, R, Guglielmo, M, Sironi, S, Esposito, A, Francone, M, Dacher, N, Peebles, C, Bastarrika, G, Salgado, R, Saba, L, Cau R., Muscogiuri G., Pisu F., Gatti M., Velthuis B., Loewe C., Cademartiri F., Pontone G., Montisci R., Guglielmo M., Sironi S., Esposito A., Francone M., Dacher N., Peebles C., Bastarrika G., Salgado R., and Saba L.

Abstract

Purpose: Takotsubo cardiomyopathy (TTC) is a transient but severe acute myocardial dysfunction with a wide range of outcomes from favorable to life-threatening. The current risk stratification scores of TTC patients do not include cardiac magnetic resonance (CMR) parameters. To date, it is still unknown whether and how clinical, trans-thoracic echocardiography (TTE), and CMR data can be integrated to improve risk stratification. Methods: EVOLUTION (Exploring the eVolution in prognOstic capabiLity of mUlti-sequence cardiac magneTIc resOnance in patieNts affected by Takotsubo cardiomyopathy) is a multicenter, international registry of TTC patients who will undergo a clinical, TTE, and CMR evaluation. Clinical data including demographics, risk factors, comorbidities, laboratory values, ECG, and results from TTE and CMR analysis will be collected, and each patient will be followed-up for in-hospital and long-term outcomes. Clinical outcome measures during hospitalization will include cardiovascular death, pulmonary edema, arrhythmias, stroke, or transient ischemic attack. Clinical long-term outcome measures will include cardiovascular death, pulmonary edema, heart failure, arrhythmias, sudden cardiac death, and major adverse cardiac and cerebrovascular events defined as a composite endpoint of death from any cause, myocardial infarction, recurrence of TTC, transient ischemic attack, and stroke. We will develop a comprehensive clinical and imaging score that predicts TTC outcomes and test the value of machine learning models, incorporating clinical and imaging parameters to predict prognosis. Conclusions: The main goal of the study is to develop a comprehensive clinical and imaging score, that includes TTE and CMR data, in a large cohort of TTC patients for risk stratification and outcome prediction as a basis for possible changes in patient management.

Published
2023

18. State-of-the-art CT and MR imaging and assessment of atherosclerotic carotid artery disease:standardization of scanning protocols and measurements-a consensus document by the European Society of Cardiovascular Radiology (ESCR)

Author

Saba, L., Loewe, C., Weikert, T., Williams, M. C., Galea, N., Budde, R. P. J., Vliegenthart, R., Velthuis, B. K., Francone, M., Bremerich, J., Natale, L., Nikolaou, K., Dacher, J. N., Peebles, C., Caobelli, F., Redheuil, A., Dewey, M., Kreitner, K. F., Salgado, R., Saba, L., Loewe, C., Weikert, T., Williams, M. C., Galea, N., Budde, R. P. J., Vliegenthart, R., Velthuis, B. K., Francone, M., Bremerich, J., Natale, L., Nikolaou, K., Dacher, J. N., Peebles, C., Caobelli, F., Redheuil, A., Dewey, M., Kreitner, K. F., and Salgado, R.

Abstract

The European Society of Cardiovascular Radiology (ESCR) is the European specialist society of cardiac and vascular imaging. This society's highest priority is the continuous improvement, development, and standardization of education, training, and best medical practice, based on experience and evidence. The present intra-society consensus is based on the existing scientific evidence and on the individual experience of the members of the ESCR writing group on carotid diseases, the members of the ESCR guidelines committee, and the members of the executive committee of the ESCR. The recommendations published herein reflect the evidence-based society opinion of ESCR. We have produced a twin-papers consensus, indicated through the documents as respectively "Part I" and "Part II." The first document (Part I) begins with a discussion of features, role, indications, and evidence for CT and MR imaging-based diagnosis of carotid artery disease for risk stratification and prediction of stroke (Section I). It then provides an extensive overview and insight into imaging-derived biomarkers and their potential use in risk stratification (Section II). Finally, detailed recommendations about optimized imaging technique and imaging strategies are summarized (Section III). The second part of this consensus paper (Part II) is focused on structured reporting of carotid imaging studies with CT/MR.

Published
2023

19. State-of-the-art CT and MR imaging and assessment of atherosclerotic carotid artery disease:the reporting-a consensus document by the European Society of Cardiovascular Radiology (ESCR)

Author

Saba, L., Loewe, C., Weikert, T., Williams, M. C., Galea, N., Budde, R. P. J., Vliegenthart, R., Velthuis, B. K., Francone, M., Bremerich, J., Natale, L., Nikolaou, K., Dacher, J. N., Peebles, C., Caobelli, F., Redheuil, A., Dewey, M., Kreitner, K. F., Salgado, R., Saba, L., Loewe, C., Weikert, T., Williams, M. C., Galea, N., Budde, R. P. J., Vliegenthart, R., Velthuis, B. K., Francone, M., Bremerich, J., Natale, L., Nikolaou, K., Dacher, J. N., Peebles, C., Caobelli, F., Redheuil, A., Dewey, M., Kreitner, K. F., and Salgado, R.

Abstract

The European Society of Cardiovascular Radiology (ESCR) is the European specialist society of cardiac and vascular imaging. This society's highest priority is the continuous improvement, development, and standardization of education, training, and best medical practice, based on experience and evidence. The present intra-society consensus is based on the existing scientific evidence and on the individual experience of the members of the ESCR writing group on carotid diseases, the members of the ESCR guidelines committee, and the members of the executive committee of the ESCR. The recommendations published herein reflect the evidence-based society opinion of ESCR. The purpose of this second document is to discuss suggestions for standardized reporting based on the accompanying consensus document part I.

Published
2023

20. Prognostic value of strain by feature-tracking cardiac magnetic resonance in arrhythmogenic right ventricular cardiomyopathy

Author

Onderzoek Precision medicine, Researchgr. Hart-brein as., Circulatory Health, Team Medisch, Brain, Arts Assistenten Cardiologie, Bourfiss, M., Prakken, N. H.J., James, C. A., Planken, R. N., Boekholdt, S. M., Ahmetagic, D., van den Berg, M. P., Tichnell, C., Van der Heijden, J. F., Loh, P., Murray, B., Tandri, H., Kamel, I., Calkins, H., Asselbergs, F. W., Zimmerman, S. L., Velthuis, B. K., Te Riele, A. S.J.M., Onderzoek Precision medicine, Researchgr. Hart-brein as., Circulatory Health, Team Medisch, Brain, Arts Assistenten Cardiologie, Bourfiss, M., Prakken, N. H.J., James, C. A., Planken, R. N., Boekholdt, S. M., Ahmetagic, D., van den Berg, M. P., Tichnell, C., Van der Heijden, J. F., Loh, P., Murray, B., Tandri, H., Kamel, I., Calkins, H., Asselbergs, F. W., Zimmerman, S. L., Velthuis, B. K., and Te Riele, A. S.J.M.

Published
2023

21. Relationship between diameter asymmetry and blood flow in the pre-communicating (A1) segment of the anterior cerebral arteries

Author

Onderzoek Beeld, Neurologen, Brain, Circulatory Health, Beeldverwerking ISI, Cancer, MS Radiologie, Regenerative Medicine and Stem Cells, Highfield Research Group, Researchgr. Hart-brein as., van Tuijl, R J, Ruigrok, Y M, Ophelders, MEH, Vos, I N, van der Schaaf, I C, Zwanenburg, JJM, Velthuis, B K, Onderzoek Beeld, Neurologen, Brain, Circulatory Health, Beeldverwerking ISI, Cancer, MS Radiologie, Regenerative Medicine and Stem Cells, Highfield Research Group, Researchgr. Hart-brein as., van Tuijl, R J, Ruigrok, Y M, Ophelders, MEH, Vos, I N, van der Schaaf, I C, Zwanenburg, JJM, and Velthuis, B K

Published
2023

22. State-of-the-art CT and MR imaging and assessment of atherosclerotic carotid artery disease: standardization of scanning protocols and measurements—a consensus document by the European Society of Cardiovascular Radiology (ESCR)

Author

Researchgr. Hart-brein as., Brain, Circulatory Health, Saba, L., Loewe, C., Weikert, T., Williams, M. C., Galea, N., Budde, R. P.J., Vliegenthart, R., Velthuis, B. K., Francone, M., Bremerich, J., Natale, L., Nikolaou, K., Dacher, J. N., Peebles, C., Caobelli, F., Redheuil, A., Dewey, M., Kreitner, K. F., Salgado, R., Researchgr. Hart-brein as., Brain, Circulatory Health, Saba, L., Loewe, C., Weikert, T., Williams, M. C., Galea, N., Budde, R. P.J., Vliegenthart, R., Velthuis, B. K., Francone, M., Bremerich, J., Natale, L., Nikolaou, K., Dacher, J. N., Peebles, C., Caobelli, F., Redheuil, A., Dewey, M., Kreitner, K. F., and Salgado, R.

Published
2023

23. State-of-the-art CT and MR imaging and assessment of atherosclerotic carotid artery disease: the reporting—a consensus document by the European Society of Cardiovascular Radiology (ESCR)

Author

Researchgr. Hart-brein as., Brain, Circulatory Health, Saba, L., Loewe, C., Weikert, T., Williams, M. C., Galea, N., Budde, R. P.J., Vliegenthart, R., Velthuis, B. K., Francone, M., Bremerich, J., Natale, L., Nikolaou, K., Dacher, J. N., Peebles, C., Caobelli, F., Redheuil, A., Dewey, M., Kreitner, K. F., Salgado, R., Researchgr. Hart-brein as., Brain, Circulatory Health, Saba, L., Loewe, C., Weikert, T., Williams, M. C., Galea, N., Budde, R. P.J., Vliegenthart, R., Velthuis, B. K., Francone, M., Bremerich, J., Natale, L., Nikolaou, K., Dacher, J. N., Peebles, C., Caobelli, F., Redheuil, A., Dewey, M., Kreitner, K. F., and Salgado, R.

Published
2023

27. Redefining the upper limits of ventricular volumes in elite athletes

Author

Verwijs, S M, primary, Van Hattum, J C, additional, Daems, J J N, additional, Planken, R N, additional, Van Randen, A, additional, Boekholdt, S M, additional, Groenink, M, additional, Nederveen, A J, additional, Prakken, N H J, additional, Moen, M H, additional, Velthuis, B K, additional, Wilde, A A M, additional, Pinto, Y M, additional, and Jorstad, H T, additional

Published
2022
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31. Detection of Early Ischemic Changes with Virtual Noncontrast Dual-Energy CT in Acute Ischemic Stroke: A Noninferiority Analysis

Author

Neurologie, Opleiding Neurologie, MS Radiologie, Brain, Cancer, Circulatory Health, Fysica Radiologie, Neurologen, Researchgr. Hart-brein as., Kauw, F., Ding, V. Y., Dankbaar, J. W., Ommen, F. van, Zhu, G., Boothroyd, D. B., Wolman, D. N., Molvin, L., de Jong, H. W.A.M., Kappelle, L. J., Velthuis, B. K., Heit, J. J., Wintermark, M., Neurologie, Opleiding Neurologie, MS Radiologie, Brain, Cancer, Circulatory Health, Fysica Radiologie, Neurologen, Researchgr. Hart-brein as., Kauw, F., Ding, V. Y., Dankbaar, J. W., Ommen, F. van, Zhu, G., Boothroyd, D. B., Wolman, D. N., Molvin, L., de Jong, H. W.A.M., Kappelle, L. J., Velthuis, B. K., Heit, J. J., and Wintermark, M.

Published
2022

34. Computed Tomographic Angiography

Author

van Leeuwen, M. S., Polman, L. J., Noordzij, J., Velthuis, B., van Waes, P. F. G. M., Vogl, Thomas J., editor, Clauß, Wolfram, editor, Li, Guo-Zhen, editor, and Yeon, Kyung Mo, editor

Published
1996
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35. Prognostic value of strain by feature-tracking cardiac magnetic resonance in arrhythmogenic right ventricular cardiomyopathy

Author

Bourfiss, M, primary, Prakken, N H J, additional, James, C A, additional, Planken, R N, additional, Boekholdt, S M, additional, Ahmetagic, D, additional, van den Berg, M P, additional, Tichnell, C, additional, Van der Heijden, J F, additional, Loh, P, additional, Murray, B, additional, Tandri, H, additional, Kamel, I, additional, Calkins, H, additional, Asselbergs, F W, additional, Zimmerman, S L, additional, Velthuis, B K, additional, and Te Riele, A S J M, additional

Published
2022
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37. Prognostic value of strain by feature-tracking cardiac magnetic resonance in arrhythmogenic right ventricular cardiomyopathy.

Author

Bourfiss, M, Prakken, N H J, James, C A, Planken, R N, Boekholdt, S M, Ahmetagic, D, Berg, M P van den, Tichnell, C, Heijden, J F Van der, Loh, P, Murray, B, Tandri, H, Kamel, I, Calkins, H, Asselbergs, F W, Zimmerman, S L, Velthuis, B K, and Riele, A S J M Te

Subjects
PATIENT aftercare, VENTRICULAR ejection fraction, RIGHT heart ventricle, ARRHYTHMOGENIC right ventricular dysplasia, MAGNETIC resonance imaging, REGRESSION analysis, RISK assessment, SYMPTOMS, DESCRIPTIVE statistics, DEATH, DISEASE risk factors, DISEASE complications
Abstract

Aims Arrhythmogenic right ventricular cardiomyopathy (ARVC) is characterized by ventricular dysfunction and ventricular arrhythmias (VA). Adequate arrhythmic risk assessment is important to prevent sudden cardiac death. We aimed to study the incremental value of strain by feature-tracking cardiac magnetic resonance imaging (FT-CMR) in predicting sustained VA in ARVC patients. Methods and results CMR images of 132 ARVC patients (43% male, 40.6 ± 16.0 years) without prior VA were analysed for global and regional right and left ventricular (RV, LV) strain. Primary outcome was sustained VA during follow-up. We performed multivariable regression assessing strain, in combination with (i) RV ejection fraction (EF); (ii) LVEF; and (iii) the ARVC risk calculator. False discovery rate adjusted P -values were given to correct for multiple comparisons and c-statistics were calculated for each model. During 4.3 (2.0–7.9) years of follow-up, 19% of patients experienced sustained VA. Compared to patients without VA, those with VA had significantly reduced RV longitudinal (P  ≤ 0.03) and LV circumferential (P  ≤ 0.04) strain. In addition, patients with VA had significantly reduced biventricular EF (P  ≤ 0.02). After correcting for RVEF, LVEF, and the ARVC risk calculator separately in multivariable analysis, both RV and LV strain lost their significance [hazard ratio 1.03–1.18, P  > 0.05]. Likewise, while strain improved the c-statistic in combination with RVEF, LVEF, and the ARVC risk calculator separately, this did not reach statistical significance (P  ≥ 0.18). Conclusion Both RV longitudinal and LV circumferential strain are reduced in ARVC patients with sustained VA during follow-up. However, strain does not have incremental value over RVEF, LVEF, and the ARVC VA risk calculator. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Coronary artery calcification in middle-aged women with premature ovarian insufficiency

Author

Gunning, M.N., Meun, C., Rijn, B.B. van, Maas, A.H.E.M., Benschop, L., Franx, A., Boersma, E., Budde, R.P.J., Appelman, Y., Lambalk, C.B., Eijkemans, M.J.C., Velthuis, B.K., Laven, J.S.E., Fauser, B.C.J.M., Baart, S., Brouwers, L., Budde, R., Cannegieter, S., Dam, V., Daan, N., Eijkemans, R., Fauser, B., Ferrari, M., Groot, C. de, Gunning, M., Hoek, A., Koffijberg, E., Koster, W., Kruit, M., Lagerweij, G., Lambalk, N., Laven, J., Linstra, K., Lugt, A. van der, Maas, A., Brink, A.M. van den, Middeldorp, S., Moons, K., Rijn, B. van, Lennep, J.R. van, Roos-Hesselink, J., Scheres, L., Schouw, Y. van der, Steegers, E., Steegers, R., Terwindt, G., Velthuis, B., Wermer, M., Zick, B., Zoet, G., CREW Consortium, Vascular Medicine, ACS - Pulmonary hypertension & thrombosis, ARD - Amsterdam Reproduction and Development, Obstetrics & Gynecology, Cardiology, Radiology & Nuclear Medicine, Internal Medicine, ACS - Atherosclerosis & ischemic syndromes, Amsterdam Reproduction & Development (AR&D), Obstetrics and gynaecology, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, ACS - Microcirculation, Reproductive Origins of Adult Health and Disease (ROAHD), and Health Technology & Services Research

Subjects
Heart disease, Endocrinology, Diabetes and Metabolism, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], UT-Hybrid-D, Primary Ovarian Insufficiency, GUIDELINES, Coronary artery disease, 0302 clinical medicine, Endocrinology, reproductive disorder, Medicine, RISK, education.field_of_study, cardiovascular, POI, Calcinosis, Middle Aged, Coronary Vessels, Menopause, risk factor, CARDIOVASCULAR-DISEASE, 030220 oncology & carcinogenesis, Cohort, Female, STROKE, MENOPAUSE, medicine.medical_specialty, Population, SOCIETY, 030209 endocrinology & metabolism, HEART-DISEASE, PROFILE, Premature ovarian insufficiency, CALCIUM, coronary artery calcium score, 03 medical and health sciences, Internal medicine, Diabetes mellitus, Humans, COMPUTED-TOMOGRAPHY, cardiovascular diseases, Risk factor, education, Aged, business.industry, nutritional and metabolic diseases, medicine.disease, 22/4 OA procedure, Case-Control Studies, business
Abstract

Item does not contain fulltext OBJECTIVE: Women with premature ovarian insufficiency (POI) enter menopause before age 40. Early menopause was associated with increased risk for coronary artery disease (CAD), death from cardiovascular disease and all-cause mortality. We compared the prevalence of CAD between middle-aged women on average 10 years following the initial POI diagnosis, with a population-based cohort. DESIGN: Cross-sectional case-control study. PARTICIPANTS: Women from two Dutch University Medical Centers above 45 years of age previously diagnosed with POI (n = 98) were selected and compared with age- and race-matched controls from the Multi-Ethnic Study of Atherosclerosis (MESA). MEASUREMENTS: The primary outcome was detectable coronary artery calcium (CAC) determined by coronary computed tomography (CCT). RESULTS: Women with POI had significantly higher blood pressure, cholesterol and glucose, despite lower BMI compared to controls. Similar proportions of detectable CAC (CAC score >0 Agatston Units) were observed in women with POI and controls (POI n = 16 (16%), controls n = 52 (18%), P = 0.40 and Padj = 0.93). In women with POI separately, we were not able to identify associations between CVD risk factors and CAC. The following CVD risk factors in controls were positively associated with CAC: age, diabetes mellitus, hypertension and LDL cholesterol. HRT use was negatively associated with CAC in controls. CONCLUSIONS: The presence of CAC did not differ significantly in women with POI around 50 years of age, compared to an age- and race-matched control group. We observe no increased calcified coronary disease in POI patients, despite the presence of unfavourable cardiovascular risk factors in these women.

Published
2019

43. Pulsatility attenuation along the carotid siphon in pseudoxanthoma elasticum

Author

Researchgr. Systems Radiology, Onderzoek Beeld, Circulatory Health, Infection & Immunity, Regenerative Medicine and Stem Cells, Cancer, MS Radiologie, Brain, Neurologen, Researchgr. Hart-brein as., MS Interne Geneeskunde, Highfield Research Group, Bartstra, J. W., van Tuijl, R. J., de Jong, P. A., Mali, W. P.T.M., van der Schaaf, I. C., Ruigrok, Y. M., Rinkel, G. J.E., Velthuis, B. K., Spiering, W., Zwanenburg, J. J.M., Researchgr. Systems Radiology, Onderzoek Beeld, Circulatory Health, Infection & Immunity, Regenerative Medicine and Stem Cells, Cancer, MS Radiologie, Brain, Neurologen, Researchgr. Hart-brein as., MS Interne Geneeskunde, Highfield Research Group, Bartstra, J. W., van Tuijl, R. J., de Jong, P. A., Mali, W. P.T.M., van der Schaaf, I. C., Ruigrok, Y. M., Rinkel, G. J.E., Velthuis, B. K., Spiering, W., and Zwanenburg, J. J.M.

Published
2021

Catalog

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