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1. mRNA-1273 vaccinated inflammatory bowel disease patients receiving TNF inhibitors develop broad and robust SARS-CoV-2-specific CD8+ T cell responses

Author

van Allaart, Renée CF., Baars, Adája E., Bekkenk, Marcel W., Bemelman, Frederike J., Boekel, Laura, Bos, Amélie V., Bosma, Angela L., Broens, Bo, Brusse, Esther, Busch, Matthias H., Cristianawati, Olvi, van Doorn, Pieter A., Elias, George, van Els, Cécile ACM., van Gils, Marit J., Goedee, H Stephan, Hijnen, Dirk Jan, Hilhorst, Marc L., Horváth, Barbara, Jallah, Papay BP., de Jongh, Rivka, Mirfazeli, Elham S., Musters, Annelie H., Keijser, Jim BD., van Kempen, Zoé LE., Killestein, Joep, Kreher, Christine, de Leeuw, Karina, van der Kooi, Anneke J., van Ouwerkerk, Lotte, van Paassen, Pieter, Cabeza, Virginia Palomares, Parra Sanchez, Agner R., Ludo van der Pol, W., Post, Nicoline F., Raaphorst, Joop, Ruiter, Annabel M., Rutgers, Abraham, Schreurs, Corine RG., Spuls, Phyllis I., Takkenberg, R Bart, Tas, Sander W., Teng, YK Onno, Vegting, Yosta, Verschuuren, Jan JGM., Voskuyl, Alexandre E., de Wit, Jelle, Wolbink, Gerrit J., van der Woude, Diane, Zwinderman, Koos AH., van den Dijssel, Jet, Duurland, Mariël C., Konijn, Veronique AL., Kummer, Laura YL., Hagen, Ruth R., Kuijper, Lisan H., Wieske, Luuk, van Dam, Koos PJ., Stalman, Eileen W., Steenhuis, Maurice, Geerdes, Dionne M., Mok, Juk Yee, Kragten, Angela HM., Menage, Charlotte, Koets, Lianne, Veldhuisen, Barbera, Verstegen, Niels JM., van der Schoot, C Ellen, van Esch, Wim JE., D'Haens, Geert RAM., Löwenberg, Mark, Volkers, Adriaan G., Rispens, Theo, Kuijpers, Taco W., Eftimov, Filip, van Gisbergen, Klaas PJM., van Ham, S Marieke, ten Brinke, Anja, and van de Sandt, Carolien E.

Published
2024
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2. mRNA-1273 vaccinated inflammatory bowel disease patients receiving TNF inhibitors develop broad and robust SARS-CoV-2-specific CD8+ T cell responses

Author

van den Dijssel, Jet, Duurland, Mariël C., Konijn, Veronique AL, Kummer, Laura YL, Hagen, Ruth R., Kuijper, Lisan H., Wieske, Luuk, van Dam, Koos PJ, Stalman, Eileen W., Steenhuis, Maurice, Geerdes, Dionne M., Mok, Juk Yee, Kragten, Angela HM, Menage, Charlotte, Koets, Lianne, Veldhuisen, Barbera, Verstegen, Niels JM, van der Schoot, C. Ellen, van Esch, Wim JE, D'Haens, Geert RAM, Löwenberg, Mark, Volkers, Adriaan G., Rispens, Theo, Kuijpers, Taco W., Eftimov, Filip, van Gisbergen, Klaas PJM, van Ham, S. Marieke, ten Brinke, Anja, van de Sandt, Carolien E., Brusse, Esther, van den Dijssel, Jet, Duurland, Mariël C., Konijn, Veronique AL, Kummer, Laura YL, Hagen, Ruth R., Kuijper, Lisan H., Wieske, Luuk, van Dam, Koos PJ, Stalman, Eileen W., Steenhuis, Maurice, Geerdes, Dionne M., Mok, Juk Yee, Kragten, Angela HM, Menage, Charlotte, Koets, Lianne, Veldhuisen, Barbera, Verstegen, Niels JM, van der Schoot, C. Ellen, van Esch, Wim JE, D'Haens, Geert RAM, Löwenberg, Mark, Volkers, Adriaan G., Rispens, Theo, Kuijpers, Taco W., Eftimov, Filip, van Gisbergen, Klaas PJM, van Ham, S. Marieke, ten Brinke, Anja, van de Sandt, Carolien E., and Brusse, Esther

Abstract

SARS-CoV-2-specific CD8+ T cells recognize conserved viral peptides and in the absence of cross-reactive antibodies form an important line of protection against emerging viral variants as they ameliorate disease severity. SARS-CoV-2 mRNA vaccines induce robust spike-specific antibody and T cell responses in healthy individuals, but their effectiveness in patients with chronic immune-mediated inflammatory disorders (IMIDs) is less well defined. These patients are often treated with systemic immunosuppressants, which may negatively affect vaccine-induced immunity. Indeed, TNF inhibitor (TNFi)-treated inflammatory bowel disease (IBD) patients display reduced ability to maintain SARS-CoV-2 antibody responses post-vaccination, yet the effects on CD8+ T cells remain unclear. Here, we analyzed the impact of IBD and TNFi treatment on mRNA-1273 vaccine-induced CD8+ T cell responses compared to healthy controls in SARS-CoV-2 experienced and inexperienced patients. CD8+ T cells were analyzed for their ability to recognize 32 SARS-CoV-2-specific epitopes, restricted by 10 common HLA class I allotypes using heterotetramer combinatorial coding. This strategy allowed in-depth ex vivo profiling of the vaccine-induced CD8+ T cell responses using phenotypic and activation markers. mRNA vaccination of TNFi-treated and untreated IBD patients induced robust spike-specific CD8+ T cell responses with a predominant central memory and activated phenotype, comparable to those in healthy controls. Prominent non-spike-specific CD8+ T cell responses were observed in SARS-CoV-2 experienced donors prior to vaccination. Non-spike-specific CD8+ T cells persisted and spike-specific CD8+ T cells notably expanded after vaccination in these patient cohorts. Our data demonstrate that regardless of TNFi treatment or prior SARS-CoV-2 infection, IBD patients benefit from vaccination by inducing a robust sp

Published
2024

3. Development and validation of a universal blood donor genotyping platform: a multinational prospective study

Author

Gleadall, Nicholas S., Veldhuisen, Barbera, Gollub, Jeremy, Butterworth, Adam S., Ord, John, Penkett, Christopher J., Timmer, Tiffany C., Sauer, Carolin M., van der Bolt, Nieke, Brown, Colin, Brugger, Kim, Dilthey, Alexander T., Duarte, Daniel, Grimsley, Shane, van den Hurk, Katja, Jongerius, John M., Luken, Jessie, Megy, Karyn, Miflin, Gail, Nelson, Christopher S., Prinsze, Femmeke J., Sambrook, Jennifer, Simeoni, Ilenia, Sweeting, Michael, Thornton, Nicole, Trompeter, Sara, Tuna, Salih, Varma, Ram, Walker, Matthew R., Danesh, John, Roberts, David J., Ouwehand, Willem H., Stirrups, Kathleen E., Rendon, Augusto, Westhoff, Connie M., Di Angelantonio, Emanuele, van der Schoot, C. Ellen, Astle, William J., Watkins, Nicholas A., and Lane, William J.

Published
2020
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4. PIGG defines the Emm blood group system

Author

Lane, William J., Aeschlimann, Judith, Vege, Sunitha, Lomas-Francis, Christine, Burgos, Anna, Mah, Helen H., Halls, Justin B. L., Baeck, Peter, Ligthart, Peter C., Veldhuisen, Barbera, Shah, Ripal J., Joshi, Sanmukh R., and Westhoff, Connie M.

Published
2021
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7. International Society of Blood Transfusion Working Party on Red Cell Immunogenetics and Blood Group Terminology Report of Basel and three virtual business meetings: Update on blood group systems

Author

Gassner, Christoph, primary, Castilho, Lilian, additional, Chen, Qing, additional, Clausen, Frederik Banch, additional, Denomme, Gregory A., additional, Flegel, Willy A., additional, Gleadall, Nick, additional, Hellberg, Åsa, additional, Ji, Yanli, additional, Keller, Margaret A., additional, Lane, William J., additional, Ligthart, Peter, additional, Lomas‐Francis, Christine, additional, Nogues, Nuria, additional, Olsson, Martin L., additional, Peyrard, Thierry, additional, Storry, Jill R., additional, Tani, Yoshihiko, additional, Thornton, Nicole, additional, van der Schoot, Ellen, additional, Veldhuisen, Barbera, additional, Wagner, Franz, additional, Weinstock, Christof, additional, Wendel, Silvano, additional, Westhoff, Connie, additional, Yahalom, Vered, additional, and Hyland, Catherine A., additional

Published
2022
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13. Rh‐null phenotype and stomatocytosis

Author

Göttgens, Eva‐Leonne, primary, Ligthart, Peter C., additional, Veldhuisen, Barbera, additional, Veldthuis, Martijn, additional, Haas, Masja, additional, and Gammeren, Adriaan J., additional

Published
2021
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16. Development and validation of a universal blood donor genotyping platform: a multinational prospective study

Author

Gleadall, Nicholas S, Veldhuisen, Barbera, Gollub, Jeremy, Butterworth, Adam S, Ord, John, Penkett, Christopher J, Timmer, Tiffany C, Sauer, Carolin M, Van Der Bolt, Nieke, Brown, Colin, Brugger, Kim, Dilthey, Alexander T, Duarte, Daniel, Grimsley, Shane, Van Den Hurk, Katja, Jongerius, John M, Luken, Jessie, Megy, Karyn, Miflin, Gail, Nelson, Christopher S, Prinsze, Femmeke J, Sambrook, Jennifer, Simeoni, Ilenia, Sweeting, Michael, Thornton, Nicole, Trompeter, Sara, Tuna, Salih, Varma, Ram, Walker, Matthew R, NIHR BioResource, Danesh, John, Roberts, David J, Ouwehand, Willem H, Stirrups, Kathleen E, Rendon, Augusto, Westhoff, Connie M, Di Angelantonio, Emanuele, Van Der Schoot, C Ellen, Astle, William J, Watkins, Nicholas A, Lane, William J, Butterworth, Adam [0000-0002-6915-9015], Sauer, Carolin [0000-0003-2168-6630], Megy, Karyn [0000-0002-2826-3879], Danesh, John [0000-0003-1158-6791], Ouwehand, Willem [0000-0002-7744-1790], Johnson, Kathleen [0000-0002-6823-3252], Rendon Restrepo, Augusto [0000-0001-8994-0039], Di Angelantonio, Emanuele [0000-0001-8776-6719], Astle, William [0000-0001-8866-6672], and Apollo - University of Cambridge Repository

Subjects
Genotype, Isoantibodies, Humans, Blood Donors, Blood Transfusion, Prospective Studies
Abstract

Each year, blood transfusions save millions of lives. However, under current blood-matching practices, sensitization to non-self-antigens is an unavoidable adverse side effect of transfusion. We describe a universal donor typing platform that could be adopted by blood services worldwide to facilitate a universal extended blood-matching policy and reduce sensitization rates. This DNA-based test is capable of simultaneously typing most clinically relevant red blood cell (RBC), human platelet (HPA), and human leukocyte (HLA) antigens. Validation was performed, using samples from 7927 European, 27 South Asian, 21 East Asian, and 9 African blood donors enrolled in 2 national biobanks. We illustrated the usefulness of the platform by analyzing antibody data from patients sensitized with multiple RBC alloantibodies. Genotyping results demonstrated concordance of 99.91%, 99.97%, and 99.03% with RBC, HPA, and HLA clinically validated typing results in 89 371, 3016, and 9289 comparisons, respectively. Genotyping increased the total number of antigen typing results available from 110 980 to >1 200 000. Dense donor typing allowed identification of 2 to 6 times more compatible donors to serve 3146 patients with multiple RBC alloantibodies, providing at least 1 match for 176 individuals for whom previously no blood could be found among the same donors. This genotyping technology is already being used to type thousands of donors taking part in national genotyping studies. Extraction of dense antigen-typing data from these cohorts provides blood supply organizations with the opportunity to implement a policy of genomics-based precision matching of blood.

Published
2020

21. Development of a recombinant anti-Vel immunoglobulin M to identify Vel-negative donors

Author

van der Rijst, Marea V. E., Lissenberg-Thunnissen, Suzanne N., Ligthart, Peter C., Visser, Remco, Jongerius, John M., Voorn, Lesley, Veldhuisen, Barbera, Vidarsson, Gestur, van den Akker, Emile, van der Schoot, C. Ellen, Graduate School, AII - Inflammatory diseases, and Landsteiner Laboratory

Abstract

BACKGROUND: Alloimmunization against the high-frequency Vel blood group antigen may result in transfusion reactions or hemolytic disease of fetus and newborn. Patients with anti-Vel alloantibodies require Vel-negative blood but Vel-negative individuals are rare (1:4000). Identification of Vel-negative donors ensures availability of Vel-negative blood; however, accurate Vel blood group typing is difficult due to variable Vel antigen expression and limited availability of anti-Vel typing sera. We report the production of a recombinant anti-Vel that also identifies weak Vel expression. STUDY DESIGN AND METHODS: A recombinant anti-Vel monoclonal antibody was produced by cloning the variable regions from an anti-Vel–specific B cell isolated from an alloimmunized patient into a vector harboring the constant regions of immunoglobulin (Ig)G1-kappa or IgM-kappa. Antibody Vel specificity was tested by reactivity to SMIM1-transfected HEK293T cells and by testing various red blood cells (RBCs) of donors with normal, weak, or no Vel expression. High-throughput donor screening applicability was tested using an automated blood group analyzer. RESULTS: A Vel-specific IgM class antibody was produced. The antibody was able to distinguish between Vel-negative and very weak Vel antigen–expressing RBCs by direct agglutination and in high-throughput settings using a fully automated blood group analyzer and performed better than currently used human anti-Vel sera. High-throughput screening of 13,288 blood donations identified three new Vel-negative donors. CONCLUSION: We generated a directly agglutinating recombinant anti-Vel IgM, M3F5S-IgM, functional in manual, automated agglutination assays and flow cytometry settings. This IgM anti-Vel will improve diagnostics by facilitating the identification of Vel-negative blood donors.

Published
2019

22. Transient and chronic childhood immune thrombocytopenia are distinctly affected by Fc-γ receptor polymorphisms

Author

Schmidt, David E, Heitink-Pollé, Katja M J, Laarhoven, Annemieke G, Bruin, Marrie C A, Veldhuisen, Barbera, Nagelkerke, Sietse Q, Kuijpers, Taco W, Porcelijn, Leendert, van der Schoot, C Ellen, Vidarsson, Gestur, de Haas, Masja, Schmidt, David E, Heitink-Pollé, Katja M J, Laarhoven, Annemieke G, Bruin, Marrie C A, Veldhuisen, Barbera, Nagelkerke, Sietse Q, Kuijpers, Taco W, Porcelijn, Leendert, van der Schoot, C Ellen, Vidarsson, Gestur, and de Haas, Masja

Published
2019

23. Location of mutations within the PKD2 gene influences clinical outcome

Author

Hateboer, Nick, Veldhuisen, Barbera, Peters, Dorien, Breuning, Martijn H., San-Millán, José L., Bogdanova, Nadja, Coto, Eliecer, Dijk, Marjan A.v., Afzal, Ali R., Jeffery, Steve, Saggar-Malik, Anand K., Torra, Roser, Dimitrakov, Dimitar, Martinez, Isabel, de Castro, Saturnino Sanz, Krawczak, Michael, and Ravine, David

Published
2000

24. Performance evaluation study of ID CORE XT, a high throughput blood group genotyping platform

Author

López, M. nica, Apraiz, Izaskun, Rubia, Montserrat, Piedrabuena, Mercedes, Azkarate, Maria, Veldhuisen, Barbera, Vesga, Miguel Á., van der Schoot, Ellen, Puente, Fernando, Tejedor, Diego, Academic Medical Center, and Landsteiner Laboratory

Subjects
Male, Blood Grouping and Crossmatching, Genotyping Techniques, Blood Group Antigens, Humans, Original Article, Female, Sensitivity and Specificity
Abstract

Background. Traditionally, red blood cell antigens have been identified using serological methods, but recent advances in molecular biology have made the implementation of methods for genetic testing of most blood group antigens possible. The goal of this study was to validate the performance of the ID CORE XT blood group typing assay. Materials and methods. One thousand independent samples from donors, patients and neonates were collected from three research institutes in Spain and the Netherlands. DNA was extracted from EDTA-anticoagulated blood. The data were processed with the ID CORE XT to obtain the genotypes and the predicted blood group phenotypes, and results were compared to those obtained with wellestablished serological and molecular methods. All 1,000 samples were typed for major blood group antigens (C, c, E, e, K) and 371-830 samples were typed for other antigens depending on the rarity and availability of serology comparators. Results. The incorrect call rate was 0%. Four "no calls" (rate: 0.014%) were resolved after repetition. The sensitivity of ID CORE XT for all phenotypes was 100% regarding serology. There was one discrepancy in E? antigen and 33 discrepancies in Fyb? antigen. After bidirectional sequencing, all discrepancies were resolved in favour of ID CORE XT (100% specificity). ID CORE XT detected infrequent antigens of Caucasians in the sample as well as rare allelic variants. Discussion. In this evaluation performed in an extensive sample following the European Directive, the ID CORE XT blood genotyping assay performed as a reliable and accurate method for correctly predicting the genotype and phenotype of clinically relevant blood group antigens.

Published
2018

25. Transient and chronic childhood immune thrombocytopenia are distinctly affected by Fc-γ receptor polymorphisms

Author

Schmidt, David E., primary, Heitink-Pollé, Katja M. J., additional, Laarhoven, Annemieke G., additional, Bruin, Marrie C. A., additional, Veldhuisen, Barbera, additional, Nagelkerke, Sietse Q., additional, Kuijpers, Taco W., additional, Porcelijn, Leendert, additional, van der Schoot, C. Ellen, additional, Vidarsson, Gestur, additional, and de Haas, Masja, additional

Published
2019
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29. Identification of Self-Limiting Pediatric Immune Thrombocytopenia at Diagnosis

Author

Schmidt, David, primary, Heitink-Pollé, Katja, additional, Mertens, Bart, additional, Laarhoven, Annemieke G., additional, Porcelijn, Leendert, additional, Veldhuisen, Barbera, additional, van der Schoot, C. Ellen, additional, Vidarsson, Gestur, additional, van der Bom, Johanna G, additional, Bruin, Marrie, additional, and De Haas, Masja, additional

Published
2018
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30. Performance evaluation study of ID RHD XT, a new genotyping assay for the detection of high‐prevalence RhD negative and weak D types

Author

Molano, Araitz, primary, Apraiz, Izaskun, additional, España, Patricia, additional, Azkarate, Maria, additional, Vesga, Miguel Ángel, additional, Rubia, Montserrat, additional, Piedrabuena, Mercedes, additional, Puente, Fernando, additional, Veldhuisen, Barbera, additional, Schoot, Ellen, additional, Tejedor, Diego, additional, and López, Mónica, additional

Published
2018
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31. A Conceptual Framework for Optimizing Blood Matching Strategies: Balancing Patient Complications Against Total Costs Incurred

Author

van Sambeeck, Joost H. J., primary, de Wit, Puck D., additional, Luken, Jessie, additional, Veldhuisen, Barbera, additional, van den Hurk, Katja, additional, van Dongen, Anne, additional, Koopman, Maria M. W., additional, van Kraaij, Marian G. J., additional, van der Schoot, C. Ellen, additional, Schonewille, Henk, additional, de Kort, Wim L. A. M., additional, and Janssen, Mart P., additional

Published
2018
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32. Fetal RHD genotyping after bone marrow transplantation

Author

Thurik, Florentine F., Page-Christiaens, Godelieve C. M. L., Ait Soussan, Aicha, Ligthart, Peter C., Cheroutre, Goedele M. A. F., Bossers, Bernadette, Veldhuisen, Barbera, van der Schoot, C. Ellen, de Haas, Masja, Other departments, Landsteiner Laboratory, and Clinical Haematology

Subjects
Medicine(all), Immunology, Immunology and Allergy, Hematology, Case Reports
Abstract

BACKGROUND: Fetal RHD genotyping allows targeted diagnostic testing, fetal surveillance, and eventually intrauterine treatment to D-alloimmunized pregnant women who carry an RHD+ fetus. However, false-positive and false-negative results of noninvasive prenatal fetal RHD genotyping have been described due to a variety of causes. In this case report we present two cases where noninvasive fetal RHD typing was complicated by a previous bone marrow transplantation (BMT). CASE REPORT: We describe two women with a history of allogeneic BMT in early childhood. Both were born D+ and received a transplant of their D– male sibling. Anti-D were detected during pregnancy in one of them. The biologic father of this pregnancy was D+. In both cases polymerase chain reaction procedures specific for RHD on maternal plasma DNA were positive whereas a D– neonate was born in one case (Case 1). CONCLUSION: False-positive results of noninvasive fetal RHD genotyping occur in D+ women transplanted with marrow of a D– donor, due to circulating cell-free DNA originating from nonhematopoietic tissue. The cases highlight that health care professionals and laboratories should be aware that allogeneic BMT can be a cause for false-positive results in fetal RHD genotyping with cell-free DNA in maternal plasma, and likewise the wrong fetal sex can be reported in the case of a male donor and a female fetus. Based on one of the cases we also recommend giving D– blood products to young female patients who receive a BMT of D– donors.

Published
2016

34. Frequency and characterization of RHD variants in serologically D- Surinamese pregnant women and D- newborns.

Author

Zonneveld, Rens, Kanhai, Humphrey H.H., Javadi, Ahmad, Veldhuisen, Barbera, Brand, Anneke, Zijlmans, Wilco C.W.R., Schoot, C. Ellen, Schonewille, Henk, van der Schoot, C Ellen, and Rhesus in Surinamese Neonates (RheSuN) Study Group

Subjects
PREGNANT women, ETHNIC groups, ERYTHROCYTES, GENE expression, POLYMERASE chain reaction
Abstract

Background: Numerous RHD variant genes affect the expression of D on the red blood cell surface. In Suriname, 4.3% of pregnant women were D-, ranging from virtually zero to 7% among ethnic groups. Characterization of RHD variants, which are associated with a variable potential to induce anti-D, is of practical clinical importance especially in case of limited access to preventive measures. Here we report on the occurrence of RHD variant genes in Surinamese serologically D- pregnant women and their D- newborns from different ethnic groups.Study Design and Methods: The RheSuN study is a cross-sectional cohort study in D- pregnant women and their newborns, who visited hospitals in Paramaribo, Suriname, during routine pregnancy care. The presence of RHD variants was investigated using quantitative polymerase chain reaction targeting RHD Exons 5 and 7 and RH-multiplex ligation-dependent probe amplification.Results: Seven RHD variant genes were detected in 35 of 84 women and four RHD variant genes in 15 of 36 newborns. The RHD*03 N.01 and RHD*08 N.01 variants represented 87% of a total of 62 variant genes. Variants were comparably frequent among ethnicities. In four cases genotyping would have changed anti-D prophylaxis policy: one woman with a RHD*01EL.01 variant, not associated with anti-D formation and three D- newborns with RHD*09.01 and RHD*09.03.01 variants, potentially capable of inducing anti-D.Conclusion: RHD variants at risk for anti-D are common among serologic D- individuals from African descent in Suriname. While genotyping D- women has limited added value, it may be considered in newborns from D- women. [ABSTRACT FROM AUTHOR]

Published
2019
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35. Sensitivity of fetal RHD screening for safe guidance of targeted anti-D immunoglobulin prophylaxis : Prospective cohort study of a nationwide programme in the Netherlands

Author

De Haas, Masja, Thurik, Florentine F., Van Der Ploeg, Catharina P B, Veldhuisen, Barbera, Hirschberg, Hoang, Soussan, Aicha Ait, Woortmeijer, Heleen, Abbink, Frithjofna, Page-Christiaens, Godelieve C M L, Scheffer, Peter G., Van Der Schoot, C. Ellen, De Haas, Masja, Thurik, Florentine F., Van Der Ploeg, Catharina P B, Veldhuisen, Barbera, Hirschberg, Hoang, Soussan, Aicha Ait, Woortmeijer, Heleen, Abbink, Frithjofna, Page-Christiaens, Godelieve C M L, Scheffer, Peter G., and Van Der Schoot, C. Ellen

Published
2016

36. Fetal RHD genotyping after bone marrow transplantation

Author

UMC Utrecht, MS Verloskunde, Other research (not in main researchprogram), Thurik, Florentine F., Page-Christiaens, Godelieve C M L, Ait Soussan, Aicha, Ligthart, Peter C., Cheroutre, Goedele M A F, Bossers, Bernadette, Veldhuisen, Barbera, van der Schoot, C. Ellen, de Haas, Masja, UMC Utrecht, MS Verloskunde, Other research (not in main researchprogram), Thurik, Florentine F., Page-Christiaens, Godelieve C M L, Ait Soussan, Aicha, Ligthart, Peter C., Cheroutre, Goedele M A F, Bossers, Bernadette, Veldhuisen, Barbera, van der Schoot, C. Ellen, and de Haas, Masja

Published
2016

37. Sensitivity of fetal RHD screening for safe guidance of targeted anti-D immunoglobulin prophylaxis: Prospective cohort study of a nationwide programme in the Netherlands

Author

UMC Utrecht, MS Verloskunde, Other research (not in main researchprogram), Arts-assistenten DV&B, De Haas, Masja, Thurik, Florentine F., Van Der Ploeg, Catharina P B, Veldhuisen, Barbera, Hirschberg, Hoang, Soussan, Aicha Ait, Woortmeijer, Heleen, Abbink, Frithjofna, Page-Christiaens, Godelieve C M L, Scheffer, Peter G., Van Der Schoot, C. Ellen, UMC Utrecht, MS Verloskunde, Other research (not in main researchprogram), Arts-assistenten DV&B, De Haas, Masja, Thurik, Florentine F., Van Der Ploeg, Catharina P B, Veldhuisen, Barbera, Hirschberg, Hoang, Soussan, Aicha Ait, Woortmeijer, Heleen, Abbink, Frithjofna, Page-Christiaens, Godelieve C M L, Scheffer, Peter G., and Van Der Schoot, C. Ellen

Published
2016

38. Validation of the multiplex ligation‐dependent probe amplification assay and its application on the distribution study of the major alleles of 17 blood group systems in C hinese donors from G uangzhou

Author

Ji, Yanli, primary, Wen, Jizhi, additional, Veldhuisen, Barbera, additional, Haer‐Wigman, Lonneke, additional, Wang, Zhen, additional, Lodén‐van Straaten, Martin, additional, Wei, Ling, additional, Luo, Guangping, additional, Fu, Yongshui, additional, and van der Schoot, C. Ellen, additional

Published
2016
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39. Sensitivity of fetalRHDscreening for safe guidance of targeted anti-D immunoglobulin prophylaxis: prospective cohort study of a nationwide programme in the Netherlands

Author

de Haas, Masja, primary, Thurik, Florentine F, additional, van der Ploeg, Catharina P B, additional, Veldhuisen, Barbera, additional, Hirschberg, Hoang, additional, Soussan, Aicha Ait, additional, Woortmeijer, Heleen, additional, Abbink, Frithjofna, additional, Page-Christiaens, Godelieve C M L, additional, Scheffer, Peter G, additional, and Ellen van der Schoot, C, additional

Published
2016
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40. Identification of a novel frequent RHCE*ce308T variant allele in Chinese D– individuals, resulting in a C+c– phenotype

Author

Stegmann, Tamara C., primary, Ji, Yanli, additional, Bijman, Renate, additional, Wang, Zhen, additional, Wen, Jizhi, additional, Wei, Ling, additional, Veldhuisen, Barbera, additional, Haer‐Wigman, Lonneke, additional, Lighthart, Peter, additional, Lodén‐van Straaten, Martin, additional, Luo, Guangping, additional, and van der Schoot, C. Ellen, additional

Published
2016
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41. Prevalence of RhD status and clinical application of non-invasive prenatal determination of fetal RHD in maternal plasma: a 5 year experience in Cyprus

Author

Papasavva, Thessalia, primary, Martin, Pete, additional, Legler, Tobias J., additional, Liasides, Marios, additional, Anastasiou, George, additional, Christofides, Agathoklis, additional, Christodoulou, Tasos, additional, Demetriou, Sotos, additional, Kerimis, Prokopis, additional, Kontos, Charis, additional, Leontiades, George, additional, Papapetrou, Demetris, additional, Patroclos, Telis, additional, Phylaktou, Marios, additional, Zottis, Nikos, additional, Karitzie, Eleni, additional, Pavlou, Eleni, additional, Kountouris, Petros, additional, Veldhuisen, Barbera, additional, van der Schoot, Ellen, additional, and Kleanthous, Marina, additional

Published
2016
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