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22 results on '"Vela, Jennifer"'

1. Actividad antiinflamatoria de Kalanchoe Pinnata. Revisión bibliográfica

Author

Escobar Posada, Iván Darío, Guerrero Almeida, Julián Gustavo, Mendoza Navarrete, María Paula, and Ortiz Vela, Jennifer Paola

Subjects
Medicina complementaria e intergradora, Inflamación, Bryophyllum pinnatum, Plantas medicinales - Inflamación, Antiinflamatorios, Kalanchoe pinnata, Flavonoides, Medicina alternativa - Fitoterapia
Abstract

Ilustraciones, algoritmos, esquemas, mapas y tablas Las plantas medicinales juegan un rol fundamental dentro de la medicina tradicional a nivel mundial debido a sus diversos usos en el tratamiento de diferentes afecciones y enfermedades. Kalanchoe pinnata es una planta de la familia de las crasuláceas para la cual se han reportado potentes compuestos fitoquímicos o metabolitos secundarios como los flavonoides, para los cuales la literatura reporta actividades antimicrobianas, antiinflamatorias, antioxidantes, antialérgicas y antitumorales. Especialización Especialista en Terapéuticas Alternativas y Farmacología Vegetal Especialización en Terapéuticas Alternativas y Farmacología Vegetal

Published
2022

2. Discovery of GS-9131: Design, synthesis and optimization of amidate prodrugs of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148

Author

Mackman, Richard L., Ray, Adrian S., Hui, Hon C., Zhang, Lijun, Birkus, Gabriel, Boojamra, Constantine G., Desai, Manoj C., Douglas, Janet L., Gao, Ying, Grant, Deborah, Laflamme, Genevieve, Lin, Kuei-Ying, Markevitch, David Y., Mishra, Ruchika, McDermott, Martin, Pakdaman, Rowchanak, Petrakovsky, Oleg V., Vela, Jennifer E., and Cihlar, Tomas

Published
2010
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7. Metabolism and Pharmacokinetics of the Anti-Hepatitis C Virus Nucleotide Prodrug GS-6620

Author

Murakami, Eisuke, primary, Wang, Ting, additional, Babusis, Darius, additional, Lepist, Eve-Irene, additional, Sauer, Dorothea, additional, Park, Yeojin, additional, Vela, Jennifer E., additional, Shih, Robert, additional, Birkus, Gabriel, additional, Stefanidis, Dimitrios, additional, Kim, Choung U., additional, Cho, Aesop, additional, and Ray, Adrian S., additional

Published
2014
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8. Desarrollo plan de renovación urbana estación central. Revitalización Nodo; transformado por el sistema de transporte masivo Transmilenio

Author

Murillo Saldaña, Gustavo Adolfo / Director, Páez Vela, Jennifer Yurani, Pulido Barragan, Yeni Natalia, Rodríguez Patarroyo, Linda Tatiana, Murillo Saldaña, Gustavo Adolfo / Director, Páez Vela, Jennifer Yurani, Pulido Barragan, Yeni Natalia, and Rodríguez Patarroyo, Linda Tatiana

Abstract

Las actuales políticas de la Administración Distrital se están enfocando a entender los grandes problemas de la ciudad para solucionarlos a través de proyectos urbanos de gran impacto para la ciudad. El Plan de Renovación Urbana Estación Central partió de la idea de un conjunto de intereses públicos y privados por desarrollar un proyecto en ésta zona. Vale la pena entender que dicho lugar contiene dinámicas sociales y urbanas que han sido determinantes para la escogencia de dicho proyecto, la zona tiene un deterioro urbano marcado en tanto en sus edificaciones físicas como en el espacio público, la realidad social que lo enmarca está llena de delincuencia y zonas rojas de prostitución. El mejoramiento y complemento del Plan Parcial de Renovación Urbana Estación Central permitirá mejorar la calidad de vida del sector a través de una estructura de nodos, que permita articularse con el sistema de Transporte masivo de la ciudad. Asimismo, nos ayuda a aportar espacios públicos y dinámicas urbanas para el sector que ayudan a la apropiación de la zona por parte de residentes y transeúntes.

Published
2013

9. Sensitivity of Mitochondrial Transcription and Resistance of RNA Polymerase II Dependent Nuclear Transcription to Antiviral Ribonucleosides

Author

Arnold, Jamie J., primary, Sharma, Suresh D., additional, Feng, Joy Y., additional, Ray, Adrian S., additional, Smidansky, Eric D., additional, Kireeva, Maria L., additional, Cho, Aesop, additional, Perry, Jason, additional, Vela, Jennifer E., additional, Park, Yeojin, additional, Xu, Yili, additional, Tian, Yang, additional, Babusis, Darius, additional, Barauskus, Ona, additional, Peterson, Blake R., additional, Gnatt, Averell, additional, Kashlev, Mikhail, additional, Zhong, Weidong, additional, and Cameron, Craig E., additional

Published
2012
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16. Design and Profiling of GS-9148, a Novel Nucleotide Analog Active against Nucleoside-Resistant Variants of Human Immunodeficiency Virus Type 1, and Its Orally Bioavailable Phosphonoamidate Prodrug, GS-9131

Author

Cihlar, Tomas, primary, Ray, Adrian S., additional, Boojamra, Constantine G., additional, Zhang, Lijun, additional, Hui, Hon, additional, Laflamme, Genevieve, additional, Vela, Jennifer E., additional, Grant, Deborah, additional, Chen, James, additional, Myrick, Florence, additional, White, Kirsten L., additional, Gao, Ying, additional, Lin, Kuei-Ying, additional, Douglas, Janet L., additional, Parkin, Neil T., additional, Carey, Anne, additional, Pakdaman, Rowchanak, additional, and Mackman, Richard L., additional

Published
2008
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18. Mechanism of Active Renal Tubular Efflux of Tenofovir

Author

Ray, Adrian S., primary, Cihlar, Tomas, additional, Robinson, Kelly L., additional, Tong, Leah, additional, Vela, Jennifer E., additional, Fuller, Michael D., additional, Wieman, Lani M., additional, Eisenberg, Eugene J., additional, and Rhodes, Gerry R., additional

Published
2006
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21. In VitroEvaluation of the Anti-HIV Activity and Metabolic Interactions of Tenofovir and Emtricitabine

Author

Borroto-Esoda, Katyna, Vela, Jennifer E, Myrick, Florence, Ray, Adrian S, and Miller, Michael D

Abstract

Background Tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) are nucleoside reverse transcriptase inhibitors (NRTIs) with once-daily dosing approved for use in HIV-1 infection. We evaluated this combination for anti-HIV activity and intracellular metabolic interactions in vitro.Methods Intracellular anabolism of combinations of FTC and tenofovir (TFV) were studied in the human T leukaemic cell line CEM and human peripheral blood mononuclear cells (PBMCs). The anti-HIV activity of the combination was studied in the human T leukaemic MT-2 cell line against wild-type or mutant virus (K65R and M184V) and in PBMCs against wild-type virus. Antiviral synergy was quantitated by isobologram and MacSynergy methods.Results Both TFV and FTC were efficiently converted to their active metabolites in PBMCs and CEM cells. In CEM cells, there was a statistically significant increase in the levels of TFV diphosphate (P=0.047) and FTC triphosphate (P=0.0069) following a 24 h incubation with the combination compared with the levels seen with the individual drugs. In PBMCs, similar levels of active metabolites were observed for each drug when they were incubated individually or in combination. The combination of TFV and FTC displayed additive to synergistic activity against HIV replication in PBMCs and resulted in strongly synergistic anti-HIV activity in MT-2 cells against both wild-type and mutant virus.Conclusions The combination of TFV and FTC showed additive to synergistic anti-HIV activity in vitro, which correlated with the levels of intracellular phosphorylation observed. These results support the use of these drugs as a dual NRTI backbone in combination therapy for the treatment of HIV-1.

Published
2006
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22. In vitro evaluation of the anti-HIV activity and metabolic interactions of tenofovir and emtricitabine.

Author

Borroto-Esoda K, Vela JE, Myrick F, Ray AS, and Miller MD

Subjects
Adenine metabolism, Adenine pharmacology, Anti-HIV Agents metabolism, Cell Line, Cell Line, Tumor, Cells, Cultured, Deoxycytidine metabolism, Deoxycytidine pharmacology, Drug Synergism, Emtricitabine, HIV-1 genetics, Humans, Lamivudine metabolism, Lamivudine pharmacology, Leukocytes, Mononuclear virology, Microbial Sensitivity Tests methods, Organophosphonates metabolism, Reverse Transcriptase Inhibitors metabolism, Tenofovir, Adenine analogs & derivatives, Anti-HIV Agents pharmacology, Deoxycytidine analogs & derivatives, HIV-1 drug effects, Organophosphonates pharmacology, Reverse Transcriptase Inhibitors pharmacology, T-Lymphocytes virology
Abstract

Background: Tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) are nucleoside reverse transcriptase inhibitors (NRTIs) with once-daily dosing approved for use in HIV-1 infection. We evaluated this combination for anti-HIV activity and intracellular metabolic interactions in vitro., Methods: Intracellular anabolism of combinations of FTC and tenofovir (TFV) were studied in the human T leukaemic cell line CEM and human peripheral blood mononuclear cells (PBMCs). The anti-HIV activity of the combination was studied in the human T leukaemic MT-2 cell line against wild-type or mutant virus (K65R and M184V) and in PBMCs against wild-type virus. Antiviral synergy was quantitated by isobologram and MacSynergy methods., Results: Both TFV and FTC were efficiently converted to their active metabolites in PBMCs and CEM cells. In CEM cells, there was a statistically significant increase in the levels of TFV diphosphate (P=0.047) and FTC triphosphate (P=0.0069) following a 24 h incubation with the combination compared with the levels seen with the individual drugs. In PBMCs, similar levels of active metabolites were observed for each drug when they were incubated iindividually or in combination. The combination of TFV and FTC displayed additive to synergistic activity against HIV replication in PBMCs and resulted in strongly synergistic anti-HIV activity in MT-2 cells against both wild-type and mutant virus., Conclusions: The combination of TFV and FTC showed additive to synergistic anti-HIV activity in vitro, which correlated with the levels of intracellular phosphorylation observed. These results support the use of these drugs as a dual NRTI backbone in combination therapy for the treatment of HIV-1.

Published
2006

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