5,196 results on '"Veit P"'
Search Results
2. Integrated clinical case discussions – a fully student-organized peer-teaching program on internal medicine
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Johannes Reifenrath, Nick Seiferth, Theresa Wilhelm, Christopher Holzmann-Littig, Veit Phillip, and Marjo Wijnen-Meijer
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Undergraduate Medical Education ,Clinical Skills ,Instructional Design ,Peer-to-Peer ,Problem-based/Clinical Case Discussion ,Special aspects of education ,LC8-6691 ,Medicine - Abstract
Abstract Background In response to students´ poor ratings of emergency remote lectures in internal medicine, a team of undergraduate medical students initiated a series of voluntary peer-moderated clinical case discussions. This study aims to describe the student-led effort to develop peer-moderated clinical case discussions focused on training cognitive clinical skill for first and second-year clinical students. Methods Following the Kern Cycle a didactic concept is conceived by matching cognitive learning theory to the competence levels of the German Medical Training Framework. A 50-item survey is developed based on previous evaluation tools and administered after each tutorial. Educational environment, cognitive congruence, and learning outcomes are assessed using pre-post-self-reports in a single-institution study. Results Over the course of two semesters 19 tutors conducted 48 tutorials. There were 794 attendances in total (273 in the first semester and 521 in the second). The response rate was 32%. The didactic concept proved successful in attaining all learning objectives. Students rated the educational environment, cognitive congruence, and tutorials overall as “very good” and significantly better than the corresponding lecture. Students reported a 70%-increase in positive feelings about being tutored by peers after the session. Conclusion Peer-assisted learning can improve students´ subjective satisfaction levels and successfully foster clinical reasoning skills. This highlights successful student contributions to the development of curricula.
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- 2022
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3. Der Raub der Bibliotheca Palatina und ihre Wiedergewinnung: Über die digitale Rückkehr des berühmtesten Heidelberger Kulturdenkmals
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Veit Probst
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Krieg ,Raub ,Bibliothek ,Bibliotheca Palatina ,Universität ,Heilig-Geist-Kirche ,General Works - Abstract
Die Heidelberger Bibliotheca Palatina galt zu Beginn des 17. Jahrhunderts neben der Biblioteca Apostolica Vaticana als die bedeutendste Bibliothek Europas. Nach der Eroberung des reformierten Heidelberg durch katholische Truppen wurde die Bibliothek 1623 in den Vatikan überführt, wo ihr größter Teil noch heute verwahrt wird. Der Aufsatz schildert in einem ersten, historischen Teil das Schicksal der Palatina zu Beginn des Dreißigjährigen Krieges. Der zweite Teil beschreibt das zehnjährige Digitalisierungsprojekt der Universitätsbibliothek im Vatikan, durch das die wertvollen Handschriften der Palatina virtuell für Heidelberg zurückgewonnen wurden.
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- 2023
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4. Identification of treatment‐induced vulnerabilities in pancreatic cancer patients using functional model systems
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Katja Peschke, Hannah Jakubowsky, Arlett Schäfer, Carlo Maurer, Sebastian Lange, Felix Orben, Raquel Bernad, Felix N Harder, Matthias Eiber, Rupert Öllinger, Katja Steiger, Melissa Schlitter, Wilko Weichert, Ulrich Mayr, Veit Phillip, Christoph Schlag, Roland M Schmid, Rickmer F Braren, Bo Kong, Ihsan Ekin Demir, Helmut Friess, Roland Rad, Dieter Saur, Günter Schneider, and Maximilian Reichert
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functional screening ,pancreatic cancer ,precision oncology ,therapy‐induced vulnerabilities ,tumor cell plasticity ,Medicine (General) ,R5-920 ,Genetics ,QH426-470 - Abstract
Abstract Despite the advance and success of precision oncology in gastrointestinal cancers, the frequency of molecular‐informed therapy decisions in pancreatic ductal adenocarcinoma (PDAC) is currently neglectable. We present a longitudinal precision oncology platform based on functional model systems, including patient‐derived organoids, to identify chemotherapy‐induced vulnerabilities. We demonstrate that treatment‐induced tumor cell plasticity in vivo distinctly changes responsiveness to targeted therapies, without the presence of a selectable genetic marker, indicating that tumor cell plasticity can be functionalized. By adding a mechanistic layer to precision oncology, adaptive processes of tumors under therapy can be exploited, particularly in highly plastic tumors, such as pancreatic cancer.
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- 2022
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- View/download PDF
5. Probabilistic Day-Ahead Battery Scheduling based on Mixed Random Variables for Enhanced Grid Operation
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Pinter, Janik, Zahn, Frederik, Beichter, Maximilian, Mikut, Ralf, and Hagenmeyer, Veit
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Mathematics - Optimization and Control ,Electrical Engineering and Systems Science - Systems and Control - Abstract
The increasing penetration of renewable energy sources introduces significant challenges to power grid stability, primarily due to their inherent variability. A new opportunity for grid operation is the smart integration of electricity production combined with battery storages in residential buildings. This study explores how residential battery systems can aid in stabilizing the power grid by flexibly managing deviations from forecasted residential power consumption and PV generation. The key contribution of this work is the development of an analytical approach that enables the asymmetric allocation of quantified power uncertainties between a residential battery system and the power grid, introducing a new degree of freedom into the scheduling problem. This is accomplished by employing mixed random variables - characterized by both continuous and discrete events - to model battery and grid power uncertainties. These variables are embedded into a continuous stochastic optimization framework, which computes probabilistic schedules for battery operation and power exchange with the grid. Test cases demonstrate that the proposed framework can be used effectively to reduce and quantify grid uncertainties while minimizing electricity costs. It is also shown that residential battery systems can be actively used to provide flexibility during critical periods of grid operation. Overall, this framework empowers prosumers to take an active role in grid stabilization, contributing to a more resilient and adaptive energy system., Comment: 12 pages, 7 figures, submitted to IREP 2025 Symposium
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- 2024
6. GPT-4o System Card
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OpenAI, Hurst, Aaron, Lerer, Adam, Goucher, Adam P., Perelman, Adam, Ramesh, Aditya, Clark, Aidan, Ostrow, AJ, Welihinda, Akila, Hayes, Alan, Radford, Alec, Mądry, Aleksander, Baker-Whitcomb, Alex, Beutel, Alex, Borzunov, Alex, Carney, Alex, Chow, Alex, Kirillov, Alex, Nichol, Alex, Paino, Alex, Renzin, Alex, Passos, Alex Tachard, Kirillov, Alexander, Christakis, Alexi, Conneau, Alexis, Kamali, Ali, Jabri, Allan, Moyer, Allison, Tam, Allison, Crookes, Amadou, Tootoochian, Amin, Tootoonchian, Amin, Kumar, Ananya, Vallone, Andrea, Karpathy, Andrej, Braunstein, Andrew, Cann, Andrew, Codispoti, Andrew, Galu, Andrew, Kondrich, Andrew, Tulloch, Andrew, Mishchenko, Andrey, Baek, Angela, Jiang, Angela, Pelisse, Antoine, Woodford, Antonia, Gosalia, Anuj, Dhar, Arka, Pantuliano, Ashley, Nayak, Avi, Oliver, Avital, Zoph, Barret, Ghorbani, Behrooz, Leimberger, Ben, Rossen, Ben, Sokolowsky, Ben, Wang, Ben, Zweig, Benjamin, Hoover, Beth, Samic, Blake, McGrew, Bob, Spero, Bobby, Giertler, Bogo, Cheng, Bowen, Lightcap, Brad, Walkin, Brandon, Quinn, Brendan, Guarraci, Brian, Hsu, Brian, Kellogg, Bright, Eastman, Brydon, Lugaresi, Camillo, Wainwright, Carroll, Bassin, Cary, Hudson, Cary, Chu, Casey, Nelson, Chad, Li, Chak, Shern, Chan Jun, Conger, Channing, Barette, Charlotte, Voss, Chelsea, Ding, Chen, Lu, Cheng, Zhang, Chong, Beaumont, Chris, Hallacy, Chris, Koch, Chris, Gibson, Christian, Kim, Christina, Choi, Christine, McLeavey, Christine, Hesse, Christopher, Fischer, Claudia, Winter, Clemens, Czarnecki, Coley, Jarvis, Colin, Wei, Colin, Koumouzelis, Constantin, Sherburn, Dane, Kappler, Daniel, Levin, Daniel, Levy, Daniel, Carr, David, Farhi, David, Mely, David, Robinson, David, Sasaki, David, Jin, Denny, Valladares, Dev, Tsipras, Dimitris, Li, Doug, Nguyen, Duc Phong, Findlay, Duncan, Oiwoh, Edede, Wong, Edmund, Asdar, Ehsan, Proehl, Elizabeth, Yang, Elizabeth, Antonow, Eric, Kramer, Eric, Peterson, Eric, Sigler, Eric, Wallace, Eric, Brevdo, Eugene, Mays, Evan, Khorasani, Farzad, Such, Felipe Petroski, Raso, Filippo, Zhang, Francis, von Lohmann, Fred, Sulit, Freddie, Goh, Gabriel, Oden, Gene, Salmon, Geoff, Starace, Giulio, Brockman, Greg, Salman, Hadi, Bao, Haiming, Hu, Haitang, Wong, Hannah, Wang, Haoyu, Schmidt, Heather, Whitney, Heather, Jun, Heewoo, Kirchner, Hendrik, Pinto, Henrique Ponde de Oliveira, Ren, Hongyu, Chang, Huiwen, Chung, Hyung Won, Kivlichan, Ian, O'Connell, Ian, Osband, Ian, Silber, Ian, Sohl, Ian, Okuyucu, Ibrahim, Lan, Ikai, Kostrikov, Ilya, Sutskever, Ilya, Kanitscheider, Ingmar, Gulrajani, Ishaan, Coxon, Jacob, Menick, Jacob, Pachocki, Jakub, Aung, James, Betker, James, Crooks, James, Lennon, James, Kiros, Jamie, Leike, Jan, Park, Jane, Kwon, Jason, Phang, Jason, Teplitz, Jason, Wei, Jason, Wolfe, Jason, Chen, Jay, Harris, Jeff, Varavva, Jenia, Lee, Jessica Gan, Shieh, Jessica, Lin, Ji, Yu, Jiahui, Weng, Jiayi, Tang, Jie, Yu, Jieqi, Jang, Joanne, Candela, Joaquin Quinonero, Beutler, Joe, Landers, Joe, Parish, Joel, Heidecke, Johannes, Schulman, John, Lachman, Jonathan, McKay, Jonathan, Uesato, Jonathan, Ward, Jonathan, Kim, Jong Wook, Huizinga, Joost, Sitkin, Jordan, Kraaijeveld, Jos, Gross, Josh, Kaplan, Josh, Snyder, Josh, Achiam, Joshua, Jiao, Joy, Lee, Joyce, Zhuang, Juntang, Harriman, Justyn, Fricke, Kai, Hayashi, Kai, Singhal, Karan, Shi, Katy, Karthik, Kavin, Wood, Kayla, Rimbach, Kendra, Hsu, Kenny, Nguyen, Kenny, Gu-Lemberg, Keren, Button, Kevin, Liu, Kevin, Howe, Kiel, Muthukumar, Krithika, Luther, Kyle, Ahmad, Lama, Kai, Larry, Itow, Lauren, Workman, Lauren, Pathak, Leher, Chen, Leo, Jing, Li, Guy, Lia, Fedus, Liam, Zhou, Liang, Mamitsuka, Lien, Weng, Lilian, McCallum, Lindsay, Held, Lindsey, Ouyang, Long, Feuvrier, Louis, Zhang, Lu, Kondraciuk, Lukas, Kaiser, Lukasz, Hewitt, Luke, Metz, Luke, Doshi, Lyric, Aflak, Mada, Simens, Maddie, Boyd, Madelaine, Thompson, Madeleine, Dukhan, Marat, Chen, Mark, Gray, Mark, Hudnall, Mark, Zhang, Marvin, Aljubeh, Marwan, Litwin, Mateusz, Zeng, Matthew, Johnson, Max, Shetty, Maya, Gupta, Mayank, Shah, Meghan, Yatbaz, Mehmet, Yang, Meng Jia, Zhong, Mengchao, Glaese, Mia, Chen, Mianna, Janner, Michael, Lampe, Michael, Petrov, Michael, Wu, Michael, Wang, Michele, Fradin, Michelle, Pokrass, Michelle, Castro, Miguel, de Castro, Miguel Oom Temudo, Pavlov, Mikhail, Brundage, Miles, Wang, Miles, Khan, Minal, Murati, Mira, Bavarian, Mo, Lin, Molly, Yesildal, Murat, Soto, Nacho, Gimelshein, Natalia, Cone, Natalie, Staudacher, Natalie, Summers, Natalie, LaFontaine, Natan, Chowdhury, Neil, Ryder, Nick, Stathas, Nick, Turley, Nick, Tezak, Nik, Felix, Niko, Kudige, Nithanth, Keskar, Nitish, Deutsch, Noah, Bundick, Noel, Puckett, Nora, Nachum, Ofir, Okelola, Ola, Boiko, Oleg, Murk, Oleg, Jaffe, Oliver, Watkins, Olivia, Godement, Olivier, Campbell-Moore, Owen, Chao, Patrick, McMillan, Paul, Belov, Pavel, Su, Peng, Bak, Peter, Bakkum, Peter, Deng, Peter, Dolan, Peter, Hoeschele, Peter, Welinder, Peter, Tillet, Phil, Pronin, Philip, Tillet, Philippe, Dhariwal, Prafulla, Yuan, Qiming, Dias, Rachel, Lim, Rachel, Arora, Rahul, Troll, Rajan, Lin, Randall, Lopes, Rapha Gontijo, Puri, Raul, Miyara, Reah, Leike, Reimar, Gaubert, Renaud, Zamani, Reza, Wang, Ricky, Donnelly, Rob, Honsby, Rob, Smith, Rocky, Sahai, Rohan, Ramchandani, Rohit, Huet, Romain, Carmichael, Rory, Zellers, Rowan, Chen, Roy, Chen, Ruby, Nigmatullin, Ruslan, Cheu, Ryan, Jain, Saachi, Altman, Sam, Schoenholz, Sam, Toizer, Sam, Miserendino, Samuel, Agarwal, Sandhini, Culver, Sara, Ethersmith, Scott, Gray, Scott, Grove, Sean, Metzger, Sean, Hermani, Shamez, Jain, Shantanu, Zhao, Shengjia, Wu, Sherwin, Jomoto, Shino, Wu, Shirong, Shuaiqi, Xia, Phene, Sonia, Papay, Spencer, Narayanan, Srinivas, Coffey, Steve, Lee, Steve, Hall, Stewart, Balaji, Suchir, Broda, Tal, Stramer, Tal, Xu, Tao, Gogineni, Tarun, Christianson, Taya, Sanders, Ted, Patwardhan, Tejal, Cunninghman, Thomas, Degry, Thomas, Dimson, Thomas, Raoux, Thomas, Shadwell, Thomas, Zheng, Tianhao, Underwood, Todd, Markov, Todor, Sherbakov, Toki, Rubin, Tom, Stasi, Tom, Kaftan, Tomer, Heywood, Tristan, Peterson, Troy, Walters, Tyce, Eloundou, Tyna, Qi, Valerie, Moeller, Veit, Monaco, Vinnie, Kuo, Vishal, Fomenko, Vlad, Chang, Wayne, Zheng, Weiyi, Zhou, Wenda, Manassra, Wesam, Sheu, Will, Zaremba, Wojciech, Patil, Yash, Qian, Yilei, Kim, Yongjik, Cheng, Youlong, Zhang, Yu, He, Yuchen, Zhang, Yuchen, Jin, Yujia, Dai, Yunxing, and Malkov, Yury
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Computer Science - Computation and Language ,Computer Science - Artificial Intelligence ,Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Computers and Society ,Computer Science - Machine Learning ,Computer Science - Sound ,Electrical Engineering and Systems Science - Audio and Speech Processing - Abstract
GPT-4o is an autoregressive omni model that accepts as input any combination of text, audio, image, and video, and generates any combination of text, audio, and image outputs. It's trained end-to-end across text, vision, and audio, meaning all inputs and outputs are processed by the same neural network. GPT-4o can respond to audio inputs in as little as 232 milliseconds, with an average of 320 milliseconds, which is similar to human response time in conversation. It matches GPT-4 Turbo performance on text in English and code, with significant improvement on text in non-English languages, while also being much faster and 50\% cheaper in the API. GPT-4o is especially better at vision and audio understanding compared to existing models. In line with our commitment to building AI safely and consistent with our voluntary commitments to the White House, we are sharing the GPT-4o System Card, which includes our Preparedness Framework evaluations. In this System Card, we provide a detailed look at GPT-4o's capabilities, limitations, and safety evaluations across multiple categories, focusing on speech-to-speech while also evaluating text and image capabilities, and measures we've implemented to ensure the model is safe and aligned. We also include third-party assessments on dangerous capabilities, as well as discussion of potential societal impacts of GPT-4o's text and vision capabilities.
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- 2024
7. Multiplicities of positive and negative pions, kaons and unidentified hadrons from deep-inelastic scattering of muons off a liquid hydrogen target
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Alexeev, G. D., Alexeev, M. G., Alice, C., Amoroso, A., Andrieux, V., Anosov, V., Augsten, K., Augustyniak, W., Azevedo, C. D. R., Badelek, B., Barth, J., Beck, R., Beckers, J., Bedfer, Y., Bernhard, J., Bodlak, M., Bradamante, F., Bressan, A., Chang, W. -C., Chatterjee, C., Chiosso, M., Chung, S. -U., Cicuttin, A., Correia, P. M. M., Crespo, M. L., D'Ago, D., Torre, S. Dalla, Dasgupta, S. S., Dasgupta, S., Delcarro, F., Denisenko, I., Denisov, O. Yu., Donskov, S. V., Doshita, N., Dreisbach, Ch., Dünnweber, W., Dusaev, R. R., Ecker, D., Eremeev, D., Faccioli, P., Faessler, M., Finger, M., Finger jr., M., Fischer, H., Flöthner, K. J., Florian, W., Friedrich, J. M., Frolov, V., Ordòñez, L. G. Garcia, Gavrichtchouk, O. P., Gerassimov, S., Giarra, J., Giordano, D., Grasso, A., Gridin, A., Perdekamp, M. Grosse, Grube, B., Grüner, M., Guskov, A., Haas, P., von Harrach, D., Hoffmann, M., d'Hose, N., Hsieh, C. -Y., Ishimoto, S., Ivanov, A., Iwata, T., Jary, V., Joosten, R., Kabuß, E., Kaspar, F., Kerbizi, A., Ketzer, B., Khatun, A., Khaustov, G. V., Klein, F., Koivuniemi, J. H., Kolosov, V. N., Horikawa, K. Kondo, Konorov, I., Korzenev, A. Yu., Kotzinian, A. M., Kouznetsov, O. M., Koval, A., Kral, Z., Kunne, F., Kurek, K., Kurjata, R. P., Lavickova, K., Levorato, S., Lian, Y. -S., Lichtenstadt, J., Lin, P. -J., Longo, R., Lyubovitskij, V. E., Maggiora, A., Makke, N., Mallot, G. K., Maltsev, A., Martin, A., Marzec, J., Matoušek, J., Matsuda, T., Pires, C. Menezes, Metzger, F., Meyer, W., Mikhailov, Yu. V., Mikhasenko, M., Mitrofanov, E., Miura, D., Miyachi, Y., Molina, R., Moretti, A., Nagaytsev, A., Neyret, D., Niemiec, M., Nový, J., Nowak, W. -D., Nukazuka, G., Olshevsky, A. G., Ostrick, M., Panzieri, D., Parsamyan, B., Paul, S., Pekeler, H., Peng, J. -C., Pešek, M., Peshekhonov, D. V., Pešková, M., Platchkov, S., Pochodzalla, J., Polyakov, V. A., Quintans, C., Reicherz, G., Riedl, C., Ryabchikov, D. I., Rychter, A., Rymbekova, A., Samoylenko, V. D., Sandacz, A., Sarkar, S., Savin, I. A., Sbrizzai, G., Schmieden, H., Selyunin, A., Sinha, L., Spülbeck, D., Srnka, A., Stolarski, M., Sulc, M., Suzuki, H., Tessaro, S., Tessarotto, F., Thiel, A., Tosello, F., Townsend, A., Triloki, T., Tskhay, V., Valinoti, B., Veit, B. M., Veloso, J. F. C. A., Vijayakumar, A., Virius, M., Wagner, M., Wallner, S., Zaremba, K., Zavertyaev, M., Zemko, M., Zemlyanichkina, E., and Ziembicki, M.
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High Energy Physics - Experiment ,High Energy Physics - Phenomenology - Abstract
The multiplicities of positive and negative pions, kaons and unidentified hadrons produced in deep-inelastic scattering are measured in bins of the Bjorken scaling variable $x$, the relative virtual-photon energy $y$ and the fraction of the virtual-photon energy transferred to the final-state hadron $z$. Data were obtained by the COMPASS Collaboration using a 160 GeV muon beam of both electric charges and a liquid hydrogen target. These measurements cover the kinematic domain with photon virtuality $Q^2 > 1$ (GeV/$c)^2$, $0.004 < x < 0.4$, $0.1 < y < 0.7$ and $0.2 < z < 0.85$, in accordance with the kinematic domain used in earlier published COMPASS multiplicity measurements with an isoscalar target. The calculation of radiative corrections was improved by using the Monte Carlo generator DJANGOH, which results in up to 12\% larger corrections in the low-$x$ region., Comment: 19 pages, 29 figures
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- 2024
8. Generating peak-aware pseudo-measurements for low-voltage feeders using metadata of distribution system operators
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Treutlein, Manuel, Schmidt, Marc, Hahn, Roman, Hertel, Matthias, Heidrich, Benedikt, Mikut, Ralf, and Hagenmeyer, Veit
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Computer Science - Machine Learning ,Electrical Engineering and Systems Science - Systems and Control - Abstract
Distribution system operators (DSOs) must cope with new challenges such as the reconstruction of distribution grids along climate neutrality pathways or the ability to manage and control consumption and generation in the grid. In order to meet the challenges, measurements within the distribution grid often form the basis for DSOs. Hence, it is an urgent problem that measurement devices are not installed in many low-voltage (LV) grids. In order to overcome this problem, we present an approach to estimate pseudo-measurements for non-measured LV feeders based on the metadata of the respective feeder using regression models. The feeder metadata comprise information about the number of grid connection points, the installed power of consumers and producers, and billing data in the downstream LV grid. Additionally, we use weather data, calendar data and timestamp information as model features. The existing measurements are used as model target. We extensively evaluate the estimated pseudo-measurements on a large real-world dataset with 2,323 LV feeders characterized by both consumption and feed-in. For this purpose, we introduce peak metrics inspired by the BigDEAL challenge for the peak magnitude, timing and shape for both consumption and feed-in. As regression models, we use XGBoost, a multilayer perceptron (MLP) and a linear regression (LR). We observe that XGBoost and MLP outperform the LR. Furthermore, the results show that the approach adapts to different weather, calendar and timestamp conditions and produces realistic load curves based on the feeder metadata. In the future, the approach can be adapted to other grid levels like substation transformers and can supplement research fields like load modeling, state estimation and LV load forecasting., Comment: 17 pages, 9 figures, 8 tables
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- 2024
9. Shedding light on Dark Sectors with high-energy muons at the NA64 experiment at the CERN SPS
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Andreev, Yu. M., Banerjee, D., Oberhauser, B. Banto, Bernhard, J., Bisio, P., Charitonidis, N., Crivelli, P., Depero, E., Dermenev, A. V., Donskov, S. V., Dusaev, R. R., Enik, T., Frolov, V. N., Gardikiotis, A., Gertsenberger, S. V., Girod, S., Gninenko, S. N., Hösgen, M., Joosten, R., Kachanov, V. A., Kambar, Y., Karneyeu, A. E., Kasianova, E. A., Kekelidze, G., Ketzer, B., Kirpichnikov, D. V., Kirsanov, M. M., Kolosov, V. N., Kramarenko, V. A., Kravchuk, L. V., Krasnikov, N. V., Kuleshov, S. V., Lyubovitskij, V. E., Lysan, V., Matveev, V. A., Fredes, R. Mena, Yanssen, R. G. Mena, Bueno, L. Molina, Mongillo, M., Peshekhonov, D. V., Polyakov, V. A., Radics, B., Salamatin, K. M., Samoylenko, V. D., Shchukin, D. A., Soto, O., Sieber, H., Tikhomirov, V. O., Tlisova, I. V., Toropin, A. N., Tuzi, M., Veit, B. M., Volkov, P. V., Volkov, V. Yu., Voronchikhin, I. V., Zamora-Saá, J., and Zhevlakov, A. S.
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High Energy Physics - Experiment - Abstract
A search for Dark Sectors is performed using the unique M2 beam line at the CERN Super Proton Synchrotron. New particles ($X$) could be produced in the bremsstrahlung-like reaction of high energy 160 GeV muons impinging on an active target, $\mu N\rightarrow\mu NX$, followed by their decays, $X\rightarrow\text{invisible}$. The experimental signature would be a scattered single muon from the target, with about less than half of its initial energy and no activity in the sub-detectors located downstream the interaction point. The full sample of the 2022 run is analyzed through the missing energy/momentum channel, with a total statistics of $(1.98\pm0.02)\times10^{10}$ muons on target. We demonstrate that various muon-philic scenarios involving different types of mediators, such as scalar or vector particles, can be probed simultaneously with such a technique. For the vector-case, besides a $L_\mu-L_\tau$ $Z'$ vector boson, we also consider an invisibly decaying dark photon ($A'\rightarrow\text{invisible}$). This search is complementary to NA64 running with electrons and positrons, thus, opening the possibility to expand the exploration of the thermal light dark matter parameter space by combining the results obtained with the three beams., Comment: 24 pages, 22 figures
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- 2024
10. Hardware-Based Microgrid Coupled to Real-Time Simulated Power Grids for Evaluating New Control Strategies in Future Energy Systems
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Kyesswa, Michael, Wiegel, Friedrich, Wachter, Jan, Kühnapfel, Uwe, Waczowicz, Simon, and Hagenmeyer, Veit
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Electrical Engineering and Systems Science - Systems and Control - Abstract
The design of new control strategies for future energy systems can neither be directly tested in real power grids nor be evaluated based on only current grid situations. In this regard, extensive tests are required in laboratory settings using real power system equipment. However, since it is impossible to replicate the entire grid section of interest, even in large-scale experiments, hardware setups must be supplemented by detailed simulations to reproduce the system under study fully. This paper presents a unique test environment in which a hardware-based microgrid environment is physically coupled with a large-scale real-time simulation framework. The setup combines the advantages of developing new solutions using hardware-based experiments and evaluating the impact on large-scale power systems using real-time simulations. In this paper, the interface between the microgrid-under-test environment and the real-time simulations is evaluated in terms of accuracy and communication delays. Furthermore, a test case is presented showing the approach's ability to test microgrid control strategies for supporting the grid. It is observed that the communication delays via the physical interface depend on the simulation sampling time and do not significantly affect the accuracy in the interaction between the hardware and the simulated grid., Comment: 16 pages, 10 figures
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- 2024
11. Counterfactual rewards promote collective transport using individually controlled swarm microrobots
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Heuthe, Veit-Lorenz, Panizon, Emanuele, Gu, Hongri, and Bechinger, Clemens
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Computer Science - Robotics ,Condensed Matter - Soft Condensed Matter - Abstract
Swarm robots offer fascinating opportunities to perform complex tasks beyond the capabilities of individual machines. Just as a swarm of ants collectively moves a large object, similar functions can emerge within a group of robots through individual strategies based on local sensing. However, realizing collective functions with individually controlled microrobots is particularly challenging due to their micrometer size, large number of degrees of freedom, strong thermal noise relative to the propulsion speed, complex physical coupling between neighboring microrobots, and surface collisions. Here, we implement Multi-Agent Reinforcement Learning (MARL) to generate a control strategy for up to 200 microrobots whose motions are individually controlled by laser spots. During the learning process, we employ so-called counterfactual rewards that automatically assign credit to the individual microrobots, which allows for fast and unbiased training. With the help of this efficient reward scheme, swarm microrobots learn to collectively transport a large cargo object to an arbitrary position and orientation, similar to ant swarms. We demonstrate that this flexible and versatile swarm robotic system is robust to variations in group size, the presence of malfunctioning units, and environmental noise. Such control strategies can potentially enable complex and automated assembly of mobile micromachines, programmable drug delivery capsules, and other advanced lab-on-a-chip applications., Comment: 40 pages, 15 figures
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- 2024
12. HADES: Detecting Active Directory Attacks via Whole Network Provenance Analytics
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Liu, Qi, Bao, Kaibin, Hassan, Wajih Ul, and Hagenmeyer, Veit
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Computer Science - Cryptography and Security - Abstract
Due to its crucial role in identity and access management in modern enterprise networks, Active Directory (AD) is a top target of Advanced Persistence Threat (APT) actors. Conventional intrusion detection systems (IDS) excel at identifying malicious behaviors caused by malware, but often fail to detect stealthy attacks launched by APT actors. Recent advance in provenance-based IDS (PIDS) shows promises by exposing malicious system activities in causal attack graphs. However, existing approaches are restricted to intra-machine tracing, and unable to reveal the scope of attackers' traversal inside a network. We propose HADES, the first PIDS capable of performing accurate causality-based cross-machine tracing by leveraging a novel concept called logon session based execution partitioning to overcome several challenges in cross-machine tracing. We design HADES as an efficient on-demand tracing system, which performs whole-network tracing only when it first identifies an authentication anomaly signifying an ongoing AD attack, for which we introduce a novel lightweight authentication anomaly detection model rooted in our extensive analysis of AD attacks. To triage attack alerts, we present a new algorithm integrating two key insights we identified in AD attacks. Our evaluations show that HADES outperforms both popular open source detection systems and a prominent commercial AD attack detector., Comment: 13 pages
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- 2024
13. Accurate and Scalable Detection and Investigation of Cyber Persistence Threats
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Liu, Qi, Shoaib, Muhammad, Rehman, Mati Ur, Bao, Kaibin, Hagenmeyer, Veit, and Hassan, Wajih Ul
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Computer Science - Cryptography and Security - Abstract
In Advanced Persistent Threat (APT) attacks, achieving stealthy persistence within target systems is often crucial for an attacker's success. This persistence allows adversaries to maintain prolonged access, often evading detection mechanisms. Recognizing its pivotal role in the APT lifecycle, this paper introduces Cyber Persistence Detector (CPD), a novel system dedicated to detecting cyber persistence through provenance analytics. CPD is founded on the insight that persistent operations typically manifest in two phases: the "persistence setup" and the subsequent "persistence execution". By causally relating these phases, we enhance our ability to detect persistent threats. First, CPD discerns setups signaling an impending persistent threat and then traces processes linked to remote connections to identify persistence execution activities. A key feature of our system is the introduction of pseudo-dependency edges (pseudo-edges), which effectively connect these disjoint phases using data provenance analysis, and expert-guided edges, which enable faster tracing and reduced log size. These edges empower us to detect persistence threats accurately and efficiently. Moreover, we propose a novel alert triage algorithm that further reduces false positives associated with persistence threats. Evaluations conducted on well-known datasets demonstrate that our system reduces the average false positive rate by 93% compared to state-of-the-art methods., Comment: 16 pages
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- 2024
14. Privacy-Preserving Multi-Center Differential Protein Abundance Analysis with FedProt
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Burankova, Yuliya, Abele, Miriam, Bakhtiari, Mohammad, von Törne, Christine, Barth, Teresa, Schweizer, Lisa, Giesbertz, Pieter, Schmidt, Johannes R., Kalkhof, Stefan, Müller-Deile, Janina, van Veelen, Peter A, Mohammed, Yassene, Hammer, Elke, Arend, Lis, Adamowicz, Klaudia, Laske, Tanja, Hartebrodt, Anne, Frisch, Tobias, Meng, Chen, Matschinske, Julian, Späth, Julian, Röttger, Richard, Schwämmle, Veit, Hauck, Stefanie M., Lichtenthaler, Stefan, Imhof, Axel, Mann, Matthias, Ludwig, Christina, Kuster, Bernhard, Baumbach, Jan, and Zolotareva, Olga
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Quantitative Biology - Quantitative Methods ,Computer Science - Machine Learning - Abstract
Quantitative mass spectrometry has revolutionized proteomics by enabling simultaneous quantification of thousands of proteins. Pooling patient-derived data from multiple institutions enhances statistical power but raises significant privacy concerns. Here we introduce FedProt, the first privacy-preserving tool for collaborative differential protein abundance analysis of distributed data, which utilizes federated learning and additive secret sharing. In the absence of a multicenter patient-derived dataset for evaluation, we created two, one at five centers from LFQ E.coli experiments and one at three centers from TMT human serum. Evaluations using these datasets confirm that FedProt achieves accuracy equivalent to DEqMS applied to pooled data, with completely negligible absolute differences no greater than $\text{$4 \times 10^{-12}$}$. In contrast, -log10(p-values) computed by the most accurate meta-analysis methods diverged from the centralized analysis results by up to 25-27. FedProt is available as a web tool with detailed documentation as a FeatureCloud App., Comment: 52 pages, 16 figures, 12 tables. Last two authors listed are joint last authors
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- 2024
15. Efficient Document Ranking with Learnable Late Interactions
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Ji, Ziwei, Jain, Himanshu, Veit, Andreas, Reddi, Sashank J., Jayasumana, Sadeep, Rawat, Ankit Singh, Menon, Aditya Krishna, Yu, Felix, and Kumar, Sanjiv
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Computer Science - Information Retrieval ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning ,Statistics - Machine Learning - Abstract
Cross-Encoder (CE) and Dual-Encoder (DE) models are two fundamental approaches for query-document relevance in information retrieval. To predict relevance, CE models use joint query-document embeddings, while DE models maintain factorized query and document embeddings; usually, the former has higher quality while the latter benefits from lower latency. Recently, late-interaction models have been proposed to realize more favorable latency-quality tradeoffs, by using a DE structure followed by a lightweight scorer based on query and document token embeddings. However, these lightweight scorers are often hand-crafted, and there is no understanding of their approximation power; further, such scorers require access to individual document token embeddings, which imposes an increased latency and storage burden. In this paper, we propose novel learnable late-interaction models (LITE) that resolve these issues. Theoretically, we prove that LITE is a universal approximator of continuous scoring functions, even for relatively small embedding dimension. Empirically, LITE outperforms previous late-interaction models such as ColBERT on both in-domain and zero-shot re-ranking tasks. For instance, experiments on MS MARCO passage re-ranking show that LITE not only yields a model with better generalization, but also lowers latency and requires 0.25x storage compared to ColBERT.
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- 2024
16. Clinical Utility of Elecsys Anti-SARS-CoV-2 S Assay in COVID-19 Vaccination: An Exploratory Analysis of the mRNA-1273 Phase 1 Trial
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Simon Jochum, Imke Kirste, Sayuri Hortsch, Veit Peter Grunert, Holly Legault, Udo Eichenlaub, Basel Kashlan, and Rolando Pajon
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SARS-CoV-2 ,COVID-19 ,quantitative serology ,vaccination ,ELISA ,Immunologic diseases. Allergy ,RC581-607 - Abstract
BackgroundThe ability to quantify an immune response after vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential. This study assessed the clinical utility of the quantitative Roche Elecsys® Anti-SARS-CoV-2 S assay (ACOV2S) using samples from the 2019-nCoV vaccine (mRNA-1273) phase 1 trial (NCT04283461).MethodsSamples from 30 healthy participants, aged 18–55 years, who received two injections with mRNA-1273 at a dose of 25 μg (n=15) or 100 μg (n=15), were collected at Days 1 (first vaccination), 15, 29 (second vaccination), 43 and 57. ACOV2S results (shown in U/mL – equivalent to BAU/mL per the first WHO international standard) were compared with results from ELISAs specific to antibodies against the Spike protein (S-2P) and the receptor binding domain (RBD) as well as neutralization tests including nanoluciferase (nLUC80), live-virus (PRNT80), and a pseudovirus neutralizing antibody assay (PsVNA50).ResultsRBD-specific antibodies were already detectable by ACOV2S at the first time point of assessment (d15 after first vaccination), with seroconversion before in all but two participants (25 μg dose group); all had seroconverted by Day 29. Across all post-baseline visits, geometric mean concentration of antibody levels was 3.27–7.48-fold higher in the 100 μg compared with the 25 μg dose group. ACOV2S measurements were highly correlated with those from RBD ELISA (Pearson’s r=0.938; p
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- 2022
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17. Autoimmune Pancreatitis Type 1 Associated with a Pancreatic Pseudocyst
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Felix Hesse, Rickmer Braren, Roland M. Schmid, and Veit Phillip
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Autoimmune pancreatitis ,Corticosteroid ,Pancreatic pseudocyst ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Pancreatic cystic lesions comprise diverse entities with different histopathological characteristics. Differential diagnosis is often challenging. Autoimmune pancreatitis (AIP) is usually not considered an underlying pathology in the differential diagnosis of peri-/pancreatic pseudo-/cystic lesions. We report the case of a 73-year-old male with diffuse pancreatic enlargement and an adjacent cystic lesion (60 × 80 mm) on computed tomography scan. Based on these imaging findings and an elevated serum IgG4 concentration, AIP complicated by a pancreatic pseudocyst was diagnosed, and treatment with glucocorticoids was started. Regular follow-ups showed a good response to treatment with regression of the pancreatic pseudocyst and remittent pancreatic swelling.
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- 2019
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18. Industrial Application of the Shapley value-based Redispatch Cost Allocation to Large-Scale Power Grids requires AC Optimal Power Flow
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Bauer, Rebecca, Dai, Xinliang, and Hagenmeyer, Veit
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Electrical Engineering and Systems Science - Systems and Control - Abstract
A burgeoning topic in the current energy transition are the huge costs of redispatch congestion management (CM) in large transmission systems. One of the German transmission system operators (TSOs) raised the critical inquiry of how to allocate the redispatch costs amongst TSOs in an equitable and beneficial way. Previously, a Shapley value-based approach has been introduced on small test grids, using the linear DC approximation of optimal power flow (OPF). However, within the application of CM, its feasibility and accuracy for large-scale power grids and its impact on the computed congestions remain uncertain. Therefore, this study investigates the applicability of the DC OPF compared to the exact AC OPF with regard to the Shapley values, for both small and large-scale grids. Numerical simulation shows significant differences in the congested lines, the overall redispatch costs, and the Shapley values. These findings suggest that for future CM, the TSOs should further investigate AC OPF solutions., Comment: 5 pages, IEEE PES General Meeting
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- 2024
19. Impact and Integration of Mini Photovoltaic Systems on Electric Power Distribution Grids
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Demirel, Gökhan, Grafenhorst, Simon, Förderer, Kevin, and Hagenmeyer, Veit
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Electrical Engineering and Systems Science - Systems and Control - Abstract
This work analyzes the impact of varying concentrations mini-photovoltaic (MPV) systems, often referred to as balcony power plants, on the stability and control of the low-voltage (LV) grid. By local energy use and potentially reversing meter operation, we focus on how these MPV systems transform grid dynamics and elucidate consumer participation in the energy transition. We scrutinize the effects of these systems on power quality, power loss, transformer loading, and the functioning of other inverter-based voltage-regulating distributed energy resources (DER). Owing to the rise in renewable output from MPVs, the emerging bidirectional energy flow poses challenges for distribution grids abundant with DERs. Our case studies, featuring sensitivity analysis and comparison of distributed and decentralized DER control strategies, highlight that autonomous inverters are essential for providing ancillary services. With the growing use of battery energy storage (BES) systems in LV grids for these services, the need for adaptable DER control strategies becomes increasingly evident., Comment: 12 pages
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- 2024
20. Design and Development of a Multi-Purpose Collaborative Remote Laboratory Platform
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Jacobs, Sven, Hardebusch, Timo, Franke, Esther, Peters, Henning, Amin, Rashed Al, Wiese, Veit, and Jaschke, Steffen
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Computer Science - Computers and Society ,Computer Science - Human-Computer Interaction - Abstract
This work-in-progress paper presents the current development of a new collaborative remote laboratory platform. The results are intended to serve as a foundation for future research on collaborative work in remote laboratories. Our platform, standing out with its adaptive and collaborative capabilities, integrates a distributed web-application for streamlined management and engagement in diverse remote educational environments., Comment: accepted at IEEE Global Engineering Education Conference 2024, Kos, Greece
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- 2024
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21. From molecular to integrative pharmacology: Schmiedeberg Medal for Franz Hofmann
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Flockerzi, Veit and Biel, Martin
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- 2024
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22. A new Entoprocta species from the northwestern Weddell Sea shelf (Southern Ocean), its soft-sediment habitat and possible polychaete hosts
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Corus, Finn, Weith, Friederike, and Veit-Köhler, Gritta
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- 2024
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23. Fusarium incarnatum Strain K23 Reprograms the Response of Tomato Seedlings to Salt Stress
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Pallavi, N., Reddy, Y. N. Priya, Govind, Geetha, Reichelt, Michael, Wekesa, Clabe, Furch, C. U. Alexandra, Grabe, Veit, Shaanker, R. Uma, Oelmüller, Ralf, and Nataraja, Karaba N.
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- 2024
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24. Preventive Measures and Risk Factors for Post-ERCP Pancreatitis: A Systematic Review and Individual Patient Data Meta-Analysis
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Sperna Weiland, Christina J., Akshintala, Venkata S., Singh, Anmol, Buxbaum, James, Choi, Jun-Ho, Elmunzer, Badih J., Fogel, Evan S., Lai, Jian-Han, Levenick, John M., Gardner, Timothy B., Lua, Guan W., Luo, Hui, de Jong, Mike, Mok, Shaffer R. S., Phillip, Veit, Singh, Vikesh, Siersema, Peter D., Drenth, Joost P. H., and van Geenen, Erwin J. M.
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- 2024
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25. Pharmacokinetic Properties of a Once-Weekly Fixed-Ratio Combination of Insulin Icodec and Semaglutide Compared with Separate Administration of Each Component in Individuals with Type 2 Diabetes Mellitus
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Westergaard, Lisbet, Alifrangis, Lene, Buckley, Stephen T., Coester, Hans Veit, Klitgaard, Thomas, Kristensen, Niels R., Nishimura, Erica, Nørgreen, Lea, Rocha, Thaís M. P., Steensgaard, Dorte B., Vegge, Andreas, and Plum-Mörschel, Leona
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- 2024
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26. Meningitis and intracranial abscess due to Mycoplasma pneumoniae in a B cell-depleted patient with multiple sclerosis
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Madžar, Dominik, Nickel, Florian T., Rothhammer, Veit, Goelitz, Philipp, Geißdörfer, Walter, Dumke, Roger, and Lang, Roland
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- 2024
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27. Evolution of T-cell fitness through AML progression: enhanced bispecific T-cell engager-mediated function of bone marrow T cells at remission compared to initial diagnosis and relapse
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Kazerani, Maryam, Marcinek, Anetta, Philipp, Nora, Brauchle, Bettina, Taylor, Jonathan Jonas, Moreno, Helena Domínguez, Terrasi, Andrea, Tast, Benjamin, Rohrbacher, Lisa, Wang, Yingshuai, Warm, Maximilian, Emhardt, Alica-Joana, Magno, Giulia, Spiekermann, Karsten, Herold, Tobias, Straub, Tobias, Theurich, Sebastian, Schotta, Gunnar, Kischel, Roman, Bücklein, Veit L., and Subklewe, Marion
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- 2024
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28. Analytical characterization of volatiles present in the whole body odour of zebra finches
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Alves Soares, Tatjana, Caspers, Barbara A., Veit, Daniel, and Loos, Helene M.
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- 2024
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29. Development of an acoustic fault diagnosis system for UAV propeller blades
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Steinhoff, Leon, Koschlik, Ann-Kathrin, Arts, Emy, Soria-Gomez, Maria, Raddatz, Florian, and Kunz, Veit Dominik
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- 2024
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30. Indicated Prevention for Children Screened in Routine Health Care: Effectiveness of a Social Skills Program on Social Anxiety and Depressive Symptoms
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Zink, Julia, Weniger, Max, Porst, Patricia Theresa, Siegmund, Cornelia Beate, McDonald, Maria, Rückert, Frank, Roessner, Veit, Knappe, Susanne, and Beesdo-Baum, Katja
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- 2024
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31. Die Synoviale Chondromatose: Ergebnisse aus dem histopathologischen Arthritisregister der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
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Kriegsmann, Stella, Krenn, Veit, and Liebisch, Martin
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- 2024
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32. Histopathologische Diagnostik bei Begutachtungsfragen von Tendo‑, Ligamento- und Meniskuspathologien
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Krenn, Veit, Blümke, Lara, and Dieckmann, Ralf
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- 2024
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33. Determinants of long-term survival in patients with IDH-mutant gliomas
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Katzendobler, Sophie, Niedermeyer, Sebastian, Blobner, Jens, Trumm, Christoph, Harter, Patrick N., von Baumgarten, Louisa, Stoecklein, Veit M., Tonn, Joerg-Christian, Weller, Michael, Thon, Niklas, and Weller, Jonathan
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- 2024
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34. Structural Learning in Autistic and Non-Autistic Children: A Replication and Extension
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Oestreicher, Svenja, Bowler, Dermot M., Derwent, Claire T., Gaigg, Sebastian B., Roessner, Veit, Vetter, Nora, Volk, Theresia, Beyer, Nicole, and Ring, Melanie
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- 2024
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35. DNA-sensing inflammasomes cause recurrent atherosclerotic stroke
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Cao, Jiayu, Roth, Stefan, Zhang, Sijia, Kopczak, Anna, Mami, Samira, Asare, Yaw, Georgakis, Marios K., Messerer, Denise, Horn, Amit, Shemer, Ruth, Jacqmarcq, Charlene, Picot, Audrey, Green, Jack P., Schlegl, Christina, Li, Xinghai, Tomas, Lukas, Dutsch, Alexander, Liman, Thomas G., Endres, Matthias, Wernsdorf, Saskia R., Fürle, Christina, Carofiglio, Olga, Zhu, Jie, Brough, David, Hornung, Veit, Dichgans, Martin, Vivien, Denis, Schulz, Christian, Dor, Yuval, Tiedt, Steffen, Sager, Hendrik B., Grosse, Gerrit M., and Liesz, Arthur
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- 2024
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36. Bacteria modulate microalgal aging physiology through the induction of extracellular vesicle production to remove harmful metabolites
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Deng, Yun, Yu, Ruyi, Grabe, Veit, Sommermann, Thomas, Werner, Markus, Vallet, Marine, Zerfaß, Christian, Werz, Oliver, and Pohnert, Georg
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- 2024
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37. Effect of serum concentrations of IL-6 and TNF-α on brain structure in anorexia nervosa: a combined cross-sectional and longitudinal study
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Bernardoni, Fabio, Tam, Friederike, Poitz, David M., Hellerhoff, Inger, Arold, Dominic, Geisler, Daniel, Lemme, Frances, Keeler, Johanna, Weidner, Kerstin, Pariante, Carmine, Roessner, Veit, King, Joseph A., and Ehrlich, Stefan
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- 2024
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38. Cultivating Excellence: Future-Proofing Medical Affairs with Tailored Talent Programs
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Reis, Florian, Rajaeean, Neda, Divarci, Reyhan Rose, Sollacher, Veit, Dworatzek, Elke, Fliegner, Daniela, Krüger, Hagen, Lenz, Christian, and Craesmeyer, Clara
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- 2024
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39. Following prevalence of myopia in a large Swiss military cohort over the last decade: where is the European “myopia boom”?
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Eppenberger, Leila Sara, Jaggi, Gregor P., Todorova, Margarita G., Messerli, Jürg, and Sturm, Veit
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- 2024
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40. Development and Validation of a Simple Tool for Predicting Pandemic-Related Psychological Distress Among Health Care Workers
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Adorjan, Kristina, Dong, Mark Sen, Wratil, Paul R., Schmacke, Niklas A., Weinberger, Tobias, Steffen, Julius, Osterman, Andreas, Choukér, Alexander, Mueller, Tonina T., Jebrini, Tarek, Wiegand, Hauke Felix, Tüscher, Oliver, Lieb, Klaus, Hornung, Veit, Falkai, Peter, Klein, Matthias, Keppler, Oliver T., and Koutsouleris, Nikolaos
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- 2024
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41. New Perspectives in Cemetery Studies: A Review Essay
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Veit, Richard
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- 2024
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42. Dietary habits, traveling and the living situation potentially influence the susceptibility to SARS-CoV-2 infection: results from healthcare workers participating in the RisCoin Study
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Wratil, Paul R., Le Thi, Thu Giang, Osterman, Andreas, Badell, Irina, Huber, Melanie, Zhelyazkova, Ana, Wichert, Sven P., Litwin, Anna, Hörmansdorfer, Stefan, Strobl, Frances, Grote, Veit, Jebrini, Tarek, Török, Helga P., Hornung, Veit, Choukér, Alexander, Koletzko, Berthold, Adorjan, Kristina, Koletzko, Sibylle, and Keppler, Oliver T.
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- 2024
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43. Arterial Pseudoaneurysm within a Pancreatic Pseudocyst
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Veit Phillip, Rickmer Braren, Nikolaus Lukas, Roland M. Schmid, and Fabian Geisler
- Subjects
Pseudoaneurysm ,Pancreatic pseudocyst ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
The formation of pancreatic pseudocysts and (pseudo-)aneurysms of intestinal vessels are rare but life-threatening complications in acute and chronic pancreatitis. Here we report the rare case of a patient suffering from chronic pancreatitis with an arterial pseudoaneurysm within a pancreatic pseudocyst and present its successful therapeutic management by angioembolization to prevent critical bleeding. A 67-year-old male with a history of chronic pancreatitis presented with severe acute abdominal pain and vomiting to the emergency department. Seven weeks prior to the present admission, a CT scan had displayed a pancreatic pseudocyst with a maximum diameter of 53 mm. A laboratory examination revealed an elevated white blood cell count (15.40 × 103/μL), as well as elevated serum lipase (191 U/L), bilirubin (1.48 mg/dL), and blood glucose (353 mg/dL) levels. Sonographically, the previously described pancreatic pseudocyst revealed a slightly increased maximum diameter of 65 mm and an inhomogeneous echo of the cystic content. A contrast-enhanced CT scan showed a further increase in maximum diameter to 70 mm of the known pseudocyst. Inside the pseudocyst, a pseudoaneurysm originating from the splenic artery with a maximum diameter of 41 mm was visualized. After interdisciplinary consultation, prophylactic coil embolization of the splenic artery was immediately performed. The pseudoaneurysm was shut off from blood supply by back-door/front-door occlusion employing 27 coils, resulting in complete exclusion of the pseudoaneurysm from the circulation. Pseudoaneurysms are a rare complication of acute and chronic pancreatitis which has been shown to be efficiently treated by coil embolization.
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- 2018
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44. Open Energy Services -- Forecasting and Optimization as a Service for Energy Management Applications at Scale
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Wölfle, David, Förderer, Kevin, Riedel, Tobias, Landwich, Lukas, Mikut, Ralf, Hagenmeyer, Veit, and Schmeck, Hartmut
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Computer Science - Software Engineering - Abstract
Energy management, in sense of computing optimized operation schedules for devices, will likely play a vital role in future carbon neutral energy systems, as it allows unlocking energy efficiency and flexibility potentials. However, energy management systems need to be applied at large scales to realize the desired effect, which clearly requires minimization of costs for setup and operation of the individual applications. In order to push the latter forward, we promote an approach to split the complex optimization algorithms employed by energy management systems into standardized components, which can be provided as a service with marginal costs at scale. This work is centered around the systematic design of a framework supporting the efficient implementation and operation of such forecasting and optimization services. Furthermore, it describes the implementation of the design concept which we release under the name \emph{Energy Service Generics} as a free and open source repository. Finally, this paper marks the starting point of the \emph{Open Energy Services} community, our effort to continuously push the development and operation of services for energy management applications at scale, for which we invite researchers and practitioners to participate.
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- 2024
45. Ensuring Data Privacy in AC Optimal Power Flow with a Distributed Co-Simulation Framework
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Dai, Xinliang, Kocher, Alexander, Kovačević, Jovana, Dindar, Burak, Jiang, Yuning, Jones, Colin N., Çakmak, Hüseyin, and Hagenmeyer, Veit
- Subjects
Computer Science - Distributed, Parallel, and Cluster Computing - Abstract
During the energy transition, the significance of collaborative management among institutions is rising, confronting challenges posed by data privacy concerns. Prevailing research on distributed approaches, as an alternative to centralized management, often lacks numerical convergence guarantees or is limited to single-machine numerical simulation. To address this, we present a distributed approach for solving AC Optimal Power Flow (OPF) problems within a geographically distributed environment. This involves integrating the energy system Co-Simulation (eCoSim) module in the eASiMOV framework with the convergence-guaranteed distributed optimization algorithm, i.e., the Augmented Lagrangian based Alternating Direction Inexact Newton method (ALADIN). Comprehensive evaluations across multiple system scenarios reveal a marginal performance slowdown compared to the centralized approach and the distributed approach executed on single machines -- a justified trade-off for enhanced data privacy. This investigation serves as empirical validation of the successful execution of distributed AC OPF within a geographically distributed environment, highlighting potential directions for future research.
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- 2024
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46. Real-Time Coordination of Integrated Transmission and Distribution Systems: Flexibility Modeling and Distributed NMPC Scheduling
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Dai, Xinliang, Guo, Yi, Jiang, Yuning, Jones, Colin N., Hug, Gabriela, and Hagenmeyer, Veit
- Subjects
Mathematics - Optimization and Control - Abstract
This paper proposes a real-time distributed operational architecture to efficiently coordinate intergrated transmission and distribution systems (ITD). At the distribution system level, the distribution system operator (DSO) computes the aggregated flexibility of all controllable devices by power-energy envelopes and provides them to the transmission system operators. At the transmission system level, a distributed nonlinear MPC approach is proposed to coordinate the economic dispatch of multiple TSOs, considering the aggregated flexibility of all distribution systems. The subproblems of the proposed approach are associated with different TSOs and individual time periods. In addition, the aggregated flexibility of controllable devices in distribution networks is encapsulated, re-calculated, and communicated through the power-energy envelopes, facilitating a reduction in computational complexity and eliminating redundant information exchanges between TSOs and DSOs, thereby enhancing privacy and security. The framework's effectiveness and applicability in real-world scenarios are validated through simulated operational scenarios on a summer day in Germany, highlighting its robustness in the face of significant prediction mismatches due to severe weather conditions.
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- 2024
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47. Wrinkling of fluid deformable surfaces
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Krause, Veit and Voigt, Axel
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Condensed Matter - Soft Condensed Matter ,Mathematical Physics - Abstract
Wrinkling instabilities of thin elastic sheets can be used to generate periodic structures over a wide range of length scales. Viscosity of the thin elastic sheet or its surrounding medium has been shown to be responsible for dynamic processes. While this has been explored for solid as well as liquid thin elastic sheets we here consider wrinkling of fluid deformable surfaces, which show a solid-fluid duality and have been established as model systems for biomembranes and cellular sheets. We use this hydrodynamic theory and numerically explore the formation of wrinkles and their coarsening, either by a continuous reduction of the enclosed volume or the continuous increase of the surface area. Both lead to almost identical results for wrinkle formation and the coarsening process, for which a universal scaling law for the wavenumber is obtained for a broad range of surface viscosity and rate of change of volume or area. However, for large Reynolds numbers and small changes in volume or area wrinkling can be suppressed and surface hydrodynamics allows for global shape changes following the minimal energy configurations of the Helfrich energy for corresponding reduced volumes.
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- 2024
48. Exploration of the Muon $g-2$ and Light Dark Matter explanations in NA64 with the CERN SPS high energy muon beam
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Andreev, Yu. M., Banerjee, D., Oberhauser, B. Banto, Bernhard, J., Bisio, P., Charitonidis, N., Crivelli, P., Depero, E., Dermenev, A. V., Donskov, S. V., Dusaev, R. R., Enik, T., Frolov, V. N., Silva, R. B. Galleguillos, Gardikiotis, A., Gertsenberger, S. V., Girod, S., Gninenko, S. N., Hoesgen, M., Kachanov, V. A., Kambar, Y., Karneyeu, A. E., Kasianova, E. A., Kekelidze, G., Ketzer, B., Kirpichnikov, D. V., Kirsanov, M. M., Kolosov, V. N., Kramarenko, V. A., Kravchuk, L. V., Krasnikov, N. V., Kuleshov, S. V., Lyubovitskij, V. E., Lysan, V., Matveev, V. A., Fredes, R. Mena, Yanssen, R. G. Mena, Bueno, L. Molina, Mongillo, M., Peshekhonov, D. V., Polyakov, V. A., Radics, B., Salamatin, K. M., Samoylenko, V. D., Shchukin, D. A., Soto, O., Sieber, H., Tikhomirov, V. O., Tlisova, I. V., Toropin, A. N., Tuzi, M., Veit, M. B., Volkov, P. V., Volkov, V. Yu., Voronchikhin, I. V., Zamora-Saa, J., and Zhevlakov, A. S.
- Subjects
High Energy Physics - Experiment ,High Energy Physics - Phenomenology - Abstract
We report on a search for a new $Z'$ ($L_\mu-L_\tau$) vector boson performed at the NA64 experiment employing a high energy muon beam and a missing energy-momentum technique. Muons from the M2 beamline at the CERN Super Proton Synchrotron with a momentum of 160 GeV/c are directed to an active target. A signal event is a single scattered muon with momentum $<$ 80 GeV/c in the final state, accompanied by missing energy, i.e. no detectable activity in the downstream calorimeters. For a total statistic of $(1.98\pm0.02)\times10^{10}$ muons on target, no event is observed in the expected signal region. This allows us to set new limits on part of the remaining $(m_{Z'},\ g_{Z'})$ parameter space which could provide an explanation for the muon $(g-2)_\mu$ anomaly. Additionally, our study excludes part of the parameter space suggested by the thermal Dark Matter relic abundance. Our results pave the way to explore Dark Sectors and light Dark Matter with muon beams in a unique and complementary way to other experiments., Comment: 5 pages, 4 figures
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- 2024
49. High-statistics measurement of Collins and Sivers asymmetries for transversely polarised deuterons
- Author
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Alexeev, G. D., Alexeev, M. G., Alice, C., Amoroso, A., Andrieux, V., Anosov, V., Asatryan, S., Augsten, K., Augustyniak, W., Azevedo, C. D. R., Badelek, B., Barth, J., Beck, R., Beckers, J., Bedfer, Y., Bernhard, J., Bodlak, M., Bradamante, F., Bressan, A., Chang, W. -C., Chatterjee, C., Chiosso, M., Chumakov, A. G., Chung, S. -U., Cicuttin, A., Correia, P. M. M., Crespo, M. L., D'Ago, D., Torre, S. Dalla, Dasgupta, S. S., Dasgupta, S., Delcarro, F., Denisenko, I., Denisov, O. Yu., Donskov, S. V., Doshita, N., Dreisbach, Ch., Dunnweber, W., Dusaev, R. R., Ecker, D., Eremeev, D., Faccioli, P., Faessler, M., Finger, M., Finger jr., M., Fischer, H., Flothner, K. J., Florian, W., Friedrich, J. M., Frolov, V., Ordonez, L. G. Garcia, Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Giarra, J., Giordano, D., Grasso, A., Gridin, A., Perdekamp, M. Grosse, Grube, B., Gruner, M., Guskov, A., Haas, P., von Harrach, D., Hoffmann, M., Hoghmrtsyan, A., d'Hose, N., Hsieh, C. -Y., Huber, S., Ishimoto, S., Ivanov, A., Iwata, T., Jary, V., Joosten, R., Kabuss, E., Kaspar, F., Kerbizi, A., Ketzer, B., Khatun, A., Khaustov, G. V., Klasek, T., Klein, F., Koivuniemi, J. H., Kolosov, V. N., Horikawa, K. Kondo, Konorov, I., Konstantinov, V. F., Korzenev, A. Yu., Kotzinian, A. M., Kouznetsov, O. M., Koval, A., Kral, Z., Krinner, F., Kunne, F., Kurek, K., Kurjata, R. P., Kveton, A., Lavickova, K., Levorato, S., Lian, Y. -S., Lichtenstadt, J., Lin, P. -J., Longo, R., Lyubovitskij, V. E., Maggiora, A., Magnon, A., Makke, N., Mallot, G. K., Maltsev, A., Martin, A., Marzec, J., Matousek, J., Matsuda, T., Mattson, G., Pires, C. Menezes, Metzger, F., Meyer, M., Meyer, W., Mikhailov, Yu. V., Mikhasenko, M., Mitrofanov, E., Miura, D., Miyachi, Y., Molina, R., Moretti, A., Movsisyan, A., Nagaytsev, A., Neyret, D., Niemiec, M., Novy, J., Nowak, W. -D., Nukazuka, G., Olshevsky, A. G., Ostrick, M., Panzieri, D., Parsamyan, B., Paul, S., Pekeler, H., Peng, J. -C., Pesek, M., Peshekhonov, D. V., Peskova, M., Platchkov, S., Pochodzalla, J., Polyakov, V. A., Quaresma, M., Quintans, C., Reicherz, G., Riedl, C., Ryabchikov, D. I., Rychter, A., Rymbekova, A., Samoylenko, V. D., Sandacz, A., Sarkar, S., Savin, I. A., Sbrizzai, G., Schmieden, H., Selyunin, A., Sharko, K., Sinha, L., Spulbeck, D., Srnka, A., Stolarski, M., Sulc, M., Suzuki, H., Takanashi, Y., Tessaro, S., Tessarotto, F., Thiel, A., Tosello, F., Townsend, A., Triloki, T., Tskhay, V., Valinoti, B., Veit, B. M., Veloso, J. F. C. A., Ventura, B., Vijayakumar, A., Virius, M., Wagner, M., Wallner, S., Zaremba, K., Zavertyaev, M., Zemko, M., Zemlyanichkina, E., and Ziembicki, M.
- Subjects
High Energy Physics - Experiment ,High Energy Physics - Phenomenology - Abstract
New results are presented on a high-statistics measurement of Collins and Sivers asymmetries of charged hadrons produced in deep inelastic scattering of muons on a transversely polarised $^6$LiD target. The data were taken in 2022 with the COMPASS spectrometer using the 160 \gevv\ muon beam at CERN, balancing the existing data on transversely polarised proton targets. The first results from about two-thirds of the new data have total uncertainties smaller by up to a factor of three compared to the previous deuteron measurements. Using all the COMPASS proton and deuteron results, both the transversity and the Sivers distribution functions of the $u$ and $d$ quark, as well as the tensor charge in the measured $x$-range are extracted. In particular, the accuracy of the $d$ quark results is significantly improved.
- Published
- 2023
50. Final COMPASS results on the transverse-spin-dependent azimuthal asymmetries in the pion-induced Drell-Yan process
- Author
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Alexeev, G. D., Alexeev, M. G., Alice, C., Amoroso, A., Andrieux, V., Anosov, V., Augsten, K., Augustyniak, W., Azevedo, C. D. R., Badelek, B., Barth, J., Beck, R., Beckers, J., Bedfer, Y., Bernhard, J., Bodlak, M., Bradamante, F., Bressan, A., Chang, W. -C., Chatterjee, C., Chiosso, M., Chumakov, A. G., Chung, S. -U., Cicuttin, A., Correia, P. M. M., Crespo, M. L., D'Ago, D., Torre, S. Dalla, Dasgupta, S. S., Dasgupta, S., Delcarro, F., Denisenko, I., Denisov, O. Yu., Donskov, S. V., Doshita, N., Dreisbach, Ch., Dunnweber, W., Dusaev, R. R., Ecker, D., Eremeev, D., Faccioli, P., Faessler, M., Finger, M., Finger jr., M., Fischer, H., Flothner, K. J., Florian, W., Friedrich, J. M., Frolov, V., Ordonez, L. G. Garcia, Gautheron, F., Gavrichtchouk, O. P., Gerassimov, S., Giarra, J., Giordano, D., Grasso, A., Gridin, A., Perdekamp, M. Grosse, Grube, B., Gruner, M., Guskov, A., Haas, P., von Harrach, D., Heitz, R., Hoffmann, M., d'Hose, N., Hsieh, C. -Y., Huber, S., Ishimoto, S., Ivanov, A., Iwata, T., Jary, V., Joosten, R., Kabuss, E., Kaspar, F., Kerbizi, A., Ketzer, B., Khatun, A., Khaustov, G. V., Klein, F., Koivuniemi, J. H., Kolosov, V. N., Horikawa, K. Kondo, Konorov, I., Konstantinov, V. F., Korzenev, A. Yu., Kotzinian, A. M., Kouznetsov, O. M., Koval, A., Kral, Z., Krinner, F., Kunne, F., Kurek, K., Kurjata, R. P., Kveton, A., Lavickova, K., Levorato, S., Lian, Y. -S., Lichtenstadt, J., Lin, P. -J., Longo, R., Lyubovitskij, V. E., Maggiora, A., Magnon, A., Makke, N., Mallot, G. K., Maltsev, A., Martin, A., Marzec, J., Matousek, J., Matsuda, T., Mattson, G., Pires, C. Menezes, Metzger, F., Meyer, M., Meyer, W., Mikhailov, Yu. V., Mikhasenko, M., Mitrofanov, E., Miura, D., Miyachi, Y., Molina, R., Moretti, A., Nagaytsev, A., Neyret, D., Niemiec, M., Novy, J., Nowak, W. -D., Nukazuka, G., Olshevsky, A. G., Ostrick, M., Panzieri, D., Parsamyan, B., Paul, S., Pekeler, H., Peng, J. -C., Pesek, M., Peshekhonov, D. V., Peskova, M., Platchkov, S., Pochodzalla, J., Polyakov, V. A., Quaresma, M., Quintans, C., Reicherz, G., Riedl, C., Ryabchikov, D. I., Rychter, A., Rymbekova, A., Samoylenko, V. D., Sandacz, A., Sarkar, S., Savada, T., Savin, I. A., Sbrizzai, G., Schmieden, H., Selyunin, A., Sharko, K., Sinha, L., Spulbeck, D., Srnka, A., Stolarski, M., Sulc, M., Suzuki, H., Tessaro, S., Tessarotto, F., Thiel, A., Tosello, F., Townsend, A., Triloki, T., Tskhay, V., Valinoti, B., Veit, B. M., Veloso, J. F. C. A., Ventura, B., Vijayakumar, A., Virius, M., Wagner, M., Wallner, S., Zaremba, K., Zavertyaev, M., Zemko, M., Zemlyanichkina, E., and Ziembicki, M.
- Subjects
High Energy Physics - Experiment ,High Energy Physics - Phenomenology - Abstract
The COMPASS Collaboration performed measurements of the Drell-Yan process in 2015 and 2018 using a 190 GeV/c $\pi^{-}$ beam impinging on a transversely polarised ammonia target. Combining the data of both years, we present final results on the amplitudes of the five azimuthal modulations in the dimuon production cross section. Three of these transverse-spin-dependent azimuthal asymmetries (TSAs) probe the nucleon leading-twist Sivers, transversity, and pretzelosity transverse-momentum dependent (TMD) parton distribution functions (PDFs). The other two are induced by subleading effects. These TSAs provide unique new inputs for the study of the nucleon TMD PDFs and their universality properties. In particular, the Sivers TSA observed in this measurement is consistent with the fundamental QCD prediction of a sign change of naive time-reversal-odd TMD PDFs when comparing the Drell-Yan process with semi-inclusive measurements of deep inelastic scattering. Also, within the context of model predictions, the observed transversity TSA is consistent with the expectation of a sign change for the Boer-Mulders function.
- Published
- 2023
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