41 results on '"Vein AA"'
Search Results
2. Space Headache During Long-Haul Flights in 66 Astronauts
- Author
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Van Oosterhout, Willebrordus Petrus Johannes, primary, Perenboom, M.L.J., additional, Terwindt, Gisela M., additional, Ferrari, Michel D., additional, and Vein, AA, additional
- Published
- 2022
- Full Text
- View/download PDF
3. Space headache: a new secondary headache
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Vein, AA, Koppen, H, Haan, J, Terwindt, GM, and Ferrari, MD
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- 2009
- Full Text
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4. Impairment of trigeminal sensory pathways in cluster headache
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Vein, AA, van Dijk, JG, and Ferrari, MD
- Published
- 2004
5. Space headache on Earth: Head-down-tilted bed rest studies simulating outer-space microgravity
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van Oosterhout, WPJ, primary, Terwindt, GM, additional, Vein, AA, additional, and Ferrari, MD, additional
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- 2014
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6. Benign familial infantile convulsions: a clinical study of seven Dutch families
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Callenbach, PMC, Coo, IFM, Vein, AA, Arts, WFM, Oosterwijk, JC, Hageman, G, ten Houten, R, Terwindt, GM, Lindhout, D (Dick), Frants, RR, Brouwer, OF, Callenbach, PMC, Coo, IFM, Vein, AA, Arts, WFM, Oosterwijk, JC, Hageman, G, ten Houten, R, Terwindt, GM, Lindhout, D (Dick), Frants, RR, and Brouwer, OF
- Published
- 2002
7. Cardiovascular Autonomic Function Tests in Cluster Headache
- Author
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van Vliet, JA, primary, Vein, AA, additional, Ferrari, MD, additional, and van Dijk, JG, additional
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- 2006
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8. MOYAMOYA SYNDROME ASSOCIATED WITH ALTERNATING HEMIPLEGIA
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Laan, LAEM, primary, Carbaat, PAT, additional, Vein, AA, additional, and Ferrari, MD, additional
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- 2006
- Full Text
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9. Reply: Impairment of Trigeminal Sensory Pathways in Cluster Headache
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Vein, AA, primary, van Dijk, JG, additional, and Ferrari, MD, additional
- Published
- 2004
- Full Text
- View/download PDF
10. Reproducibility and Feasibility of Neurophysiological Assessment of the Sensory Trigeminal System for Future Application To Paroxysmal Headaches
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van Vliet, JA, primary, Vein, AA, additional, le Cessie, S, additional, Ferrari, MD, additional, and van Dijk, JG, additional
- Published
- 2002
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11. EEG markers of future cognitive performance in the elderly.
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van der Hiele K, Bollen EL, Vein AA, Reijntjes RH, Westendorp RG, van Buchem MA, Middelkoop HA, and van Dijk JG
- Published
- 2008
- Full Text
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12. Leo Tolstoy's theory of sleep.
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Vein AA and Vein, Alla A
- Abstract
Throughout his life, Leo Tolstoy was fascinated by the phenomena of sleep and dreams. He composed a series of observations and judgements that were brought together under "my theory of sleep". Tolstoy was constantly preoccupied with the basic principles of "the theory". It is hard to name a work by him where a description of sleep and/or a dream does not play a vital role in the unfolding of the plot. They testify to Tolstoy's interest in the mechanism of sleep and in the processes of falling asleep and waking up. Tolstoy viewed sleep as a specific state of consciousness, and he subsequently linked the concept of sleep with the concept of death. For him sleep and awakening were experiences emblematic of life and death. [ABSTRACT FROM AUTHOR]
- Published
- 2008
- Full Text
- View/download PDF
13. Impairment of trigeminal sensory pathways in cluster headache.
- Author
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van Vliet, JA, Vein, AA, Le Cessie, S, Ferrari, MD, and van Dijk, JG
- Subjects
- *
TRIGEMINAL nerve diseases , *CLUSTER headache , *SOMATOSENSORY evoked potentials , *NEURAL circuitry , *REFLEX testing - Abstract
Cluster headache (CH) typically presents in clusters of attacks of intense (peri)orbital, unilateral pain. The distribution of the pain implies involvement of central and/or peripheral trigeminal pathways. These can be investigated by means of trigeminal somatosensory evoked potentials (TSEP) and blink reflexes (BR). We aimed to relate functional changes in trigeminal sensory pathways to the presence of cluster periods. TSEP and BR were performed in 28 episodic CH patients during a cluster period and repeated in 22 outside a cluster period. TSEP latencies (N1, P1 and N2) and amplitude (N1-P1 and P1-N2) and BR latencies (R1, R2 ipsilateral and R2 contralateral) were compared between sides, during and outside a cluster period and with healthy control data (n = 22). During a cluster period, N2 TSEP latencies were longer on the symptomatic side compared with the non-symptomatic side (27.2 ± 3.0 ms vs. 26.3 ± 3.4 ms, P = 0.02), and compared with the same side outside the cluster period (26.7 ± 3.1 ms vs. 25.1 ± 3.0 ms, P = 0.01). N1, P1 and N2 latencies on the symptomatic side in patients during the cluster period (14.8 ± 2.3 ms, 20.4 ± 2.5 ms and 27.2 ± 3.0 ms, respectively) were significantly longer than those of healthy controls (13.4 ± 1.9 ms, 18.8 ± 2.4 ms and 25.0 ± 2.6 ms, respectively, P < 0.03). Outside the cluster period, N1 latencies of both sides (15.3 ± 2.8 ms symptomatic side and 15.4 ± 2.6 ms asymptomatic side) were longer compared with controls (13.4 ± 1.9 ms, P < 0.04). TSEP amplitudes and BR latencies revealed no significant differences. We conclude that abnormalities of the afferent trigeminal pathway are present in patients with cluster headache, most prominent during the cluster period, and on the symptomatic side. This seems primarily due of changes within the higher cerebral regions of the system. [ABSTRACT FROM AUTHOR]
- Published
- 2003
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14. Single-fiber EMG in familial hemiplegic migraine.
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Schoenen JE, Ambrosini A, de Noordhout AM, van Dijk JG, Terwindt GM, Kors EE, Vein AA, Ferrari MD, Schoenen, Jean E, Ambrosini, Anna, and de Noordhout, Alain Maertens
- Published
- 2005
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15. Space headache on Earth: Head-down-tilted bed rest studies simulating outer-space microgravity.
- Author
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van Oosterhout, WPJ, Terwindt, GM, Vein, AA, and Ferrari, MD
- Subjects
- *
HEADACHE , *PHYSIOLOGICAL effects of space travel , *PHYSIOLOGICAL effects of reduced gravity environments , *HEAD-down tilt position , *HEAD diseases - Abstract
Abstract Background: Headache is a common symptom during space travel, both isolated and as part of space motion syndrome. Head-down-tilted bed rest (HDTBR) studies are used to simulate outer space microgravity on Earth, and allow countermeasure interventions such as artificial gravity and training protocols, aimed at restoring microgravity-induced physiological changes. Objectives: The objectives of this article are to assess headache incidence and characteristics during HDTBR, and to evaluate the effects of countermeasures. Methods: In a randomized cross-over design by the European Space Agency (ESA), 22 healthy male subjects, without primary headache history, underwent three periods of -6-degree HDTBR. In two of these episodes countermeasure protocols were added, with either centrifugation or aerobic exercise training protocols. Headache occurrence and characteristics were daily assessed using a specially designed questionnaire. Results: In total 14/22 (63.6%) subjects reported a headache during ≥1 of the three HDTBR periods, in 12/14 (85.7%) non-specific, and two of 14 (14.4%) migraine. The occurrence of headache did not differ between HDTBR with and without countermeasures: 12/22 (54.5%) subjects vs. eight of 22 (36.4%) subjects; p=0.20; 13/109 (11.9%) headache days vs. 36/213 (16.9%) headache days; p=0.24). During countermeasures headaches were, however, more often mild (p=0.03) and had fewer associated symptoms (p=0.008). Conclusions: Simulated microgravity during HDTBR induces headache episodes, mostly on the first day. Countermeasures are useful in reducing headache severity and associated symptoms. Reversible, microgravity-induced cephalic fluid shift may cause headache, also on Earth. HDTBR can be used to study space headache on Earth. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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16. Frequency and Clinical Features of Space Headache Experienced by Astronauts During Long-Haul Space Flights.
- Author
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van Oosterhout WPJ, Perenboom MJL, Terwindt GM, Ferrari MD, and Vein AA
- Subjects
- Male, Humans, Adult, Middle Aged, Female, Astronauts, Retrospective Studies, Carbon Dioxide, Prospective Studies, Headache epidemiology, Headache etiology, Space Flight, Migraine Disorders
- Abstract
Background and Objectives: Few anecdotal cases and 1 small retrospective study during short-duration space missions suggest that headache may occur early in flight, as part of the space motion syndrome. Whether headaches may also occur at later stages of space flights is unknown. We aimed to prospectively characterize the incidence, timing, clinical features, and management of space headaches during long-duration flights., Methods: We prospectively evaluated the occurrence, characteristics, and evolution of space headaches and the effects of treatment and countermeasures during long-haul flights with onboard questionnaires and correlated them with prevailing temperature, pressure, and ambient O
2 and CO2 levels, measured within the International Space Station. In addition, we analyzed retrospective headache data from a different astronaut cohort. Headache data were reported using descriptive statistics and correlation data with intraindividual logistic regression models. Astronauts were included through (inter)national aerospace organizations., Results: In the prospective study, 22/24 (91.7%) astronauts (mean ± SD age: 46.6 ± 6.5 years, 95.8% male) experienced ≥1 episode of headache during a total of 3,596 space days. A total of 378 episodes were reported (median 9; range 1-128) with detailed information on 189. Phenotypically, 170/189 (89.9%) episodes were tension-type headache (TTH) and 19/189 (10.1%) were migraine. Episodes in the first week differed from those in later periods in terms of phenotype (migraine 12/51 [23.5%] vs 7/138 [5.1%]; TTH 39/51 [86.5%] vs 131/138 [94.9%]; overall p = 0.0002) and accompanying symptoms: nausea: 17.6% vs 6.9%, p = 0.05; vomiting: 9.8% vs 0.7%, p = 0.005; nasal congestion: 52.9% vs 29.7%, p = 0.004; facial edema: 41.2% vs 1.4%, p < 0.001; and duration ( p = 0.001). Severity and treatments were similar: acute antiheadache medication: 55.6%; other medication: 22.4%; and alternative treatments: 41.1%. Headache occurrence was not associated with temperature or ambient pressure/levels of O2 and CO2 (all p > 0.05). In the retrospective study, 23/42 (54.8%) astronauts (43.5 ± 7.2 years, 90.5% male) reported experiencing ≥1 headache episode during mission. Nasal congestion was the most common (8/33; 24.2%) accompanying symptom. Seventeen of 42 astronauts have been previously described., Discussion: Astronauts during space flights frequently experience headaches. These most often have characteristics of TTHs but sometimes have migrainous features, particularly during the first week of flight in astronauts without a history of recurrent headaches before or after the space flight.- Published
- 2024
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17. Early recognition of characteristic conventional and amplitude-integrated EEG patterns of seizures in SCN2A and KCNQ3-related epilepsy in neonates.
- Author
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Pijpers JA, Au PYB, Weeke LC, Vein AA, Smit LS, Vilan A, Jacobs E, de Vries LS, Steggerda SJ, Cilio MR, Carapancea E, Cornet MC, Appendino JP, and Peeters-Scholte CMPCD
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- Infant, Newborn, Humans, Sodium Channel Blockers, KCNQ2 Potassium Channel genetics, Cognition, NAV1.2 Voltage-Gated Sodium Channel genetics, Electroencephalography methods, Epilepsy
- Abstract
Purpose: Early recognition of seizures in neonates secondary to pathogenic variants in potassium or sodium channel coding genes is crucial, as these seizures are often resistant to commonly used anti-seizure medications but respond well to sodium channel blockers. Recently, a characteristic ictal amplitude-integrated electroencephalogram (aEEG) pattern was described in neonates with KCNQ2-related epilepsy. We report a similar aEEG pattern in seizures caused by SCN2A- and KCNQ3-pathogenic variants, as well as conventional EEG (cEEG) descriptions., Methods: International multicentre descriptive study, reporting clinical characteristics, aEEG and cEEG findings of 13 neonates with seizures due to pathogenic SCN2A- and KCNQ3-variants. As a comparison group, aEEGs and cEEGs of neonates with seizures due to hypoxic-ischemic encephalopathy (n = 117) and other confirmed genetic causes affecting channel function (n = 55) were reviewed., Results: In 12 out of 13 patients, the aEEG showed a characteristic sequence of brief onset with a decrease, followed by a quick rise, and then postictal amplitude attenuation. This pattern correlated with bilateral EEG onset attenuation, followed by rhythmic discharges ending in several seconds of post-ictal amplitude suppression. Apart from patients with KCNQ2-related epilepsy, none of the patients in the comparison groups had a similar aEEG or cEEG pattern., Discussion: Seizures in SCN2A- and KCNQ3-related epilepsy in neonates can usually be recognized by a characteristic ictal aEEG pattern, previously reported only in KCNQ2-related epilepsy, extending this unique feature to other channelopathies. Awareness of this pattern facilitates the prompt initiation of precision treatment with sodium channel blockers even before genetic results are available., Competing Interests: Declaration of Competing Interest C. M. P. C. D. Peeters-Scholte is founder and consultant at Neurophyxia BV. She holds several patents and stocks of Neurophyxia BV. None of this work has a relationship with the current manuscript. The other authors report no conflicts of interest, according to ICMJE recommendations., (Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2023
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18. Claw hand in a Renaissance portrait.
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Vein AA and Mouret A
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- Hand anatomy & histology, Hand Deformities, History, 15th Century, History, 16th Century, Humans, Paintings history, Portraits as Topic history
- Published
- 2018
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19. The Look of the Devil: Multiple Cranial Neuropathies.
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Vein AA
- Subjects
- Germany, History, 19th Century, Humans, Cranial Nerve Diseases, Medicine in the Arts history
- Abstract
The sculpture of the devil on a portal of the Lichtenthal Abbey School in Baden-Baden, Germany displays neurological pathology, possibly consistent with multiple cranial neuropathy. One of the main abnormalities is an exotropia strabismus, a feature rarely depicted in works of art portraying the devil., (© 2017 S. Karger AG, Basel.)
- Published
- 2017
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20. Headache under simulated microgravity is related to endocrine, fluid distribution, and tight junction changes.
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Feuerecker M, van Oosterhout WPJ, Feuerecker B, Matzel S, Schelling G, Rehm M, Vein AA, and Choukèr A
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- Adult, Cholera Toxin metabolism, Cross-Over Studies, Drinking, Endothelium metabolism, Epinephrine urine, Erythrocyte Count, Glycocalyx metabolism, Haptoglobins, Head-Down Tilt, Hematocrit, Hemoglobins metabolism, Humans, Male, Pain Measurement, Protein Precursors, Saliva, Weightlessness, Young Adult, Headache metabolism, Headache pathology, Hydrocortisone metabolism, Tight Junctions pathology, Weightlessness Simulation
- Abstract
Head-down-tilted bed rest (HDTBR) induces headaches similar to headaches during space flights. The objective of this investigation was to study hematological, endocrinological, fluid changes and tight junctions in HDTBR-induced headaches as a proxy for space headache. The randomized crossover HDTBR design by the European Space Agency included 12 healthy, nonheadache male subjects. Before, during, and after confined HDTBR periods, epinephrine (urine), cortisol (saliva), hematological, endothelium markers, and fluid distribution parameters were measured. Headaches were assessed with a validated headache questionnaire. Compared with baseline, HDTBR in all subjects was associated with higher hematocrit, hemoglobin, and epinephrine levels, higher erythrocyte counts, and lower relative plasma volumes (all P < 0.05). In total, 26 headache episodes occurred. In subjects with headaches during HDTBR, epinephrine levels were exaggerated (vs headache-free subjects; HDTBR day 3; 5.1 ± 1.7 vs 3.4 ± 2.4; P = 0.023), cortisol levels were decreased (vs headache-free subjects; HDTBR day 1; 0.37 ± 0.16 vs 0.50 ± 0.20; P < 0.001) and the tight junction marker zonulin was elevated (vs headache-free subjects in HDTBR days 1, 3, 5; P < 0.05). HDTBR induces hemoconcentration and fluid redistribution in all subjects. During headache episodes, endocrinological changes, fluid distribution, and tight junctions were more pronounced, suggesting an additional role in headache pathophysiology.
- Published
- 2016
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21. Sergey Sukhanov, a Russian Physician in Professor Arthur Van Gehuchten's Lab - Based on Original 19th Century Documents.
- Author
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Vein AA and Aubert G
- Subjects
- Belgium, History, 19th Century, History, 20th Century, Humans, Russia, Universities, Neurology history
- Abstract
In 1898, Russian physician Sergey Alexeevich Sukhanov (1867-1915) spent a 3-month traineeship in Professor Arthur Van Gehuchten's anatomy laboratory in Louvain (Belgium). A folder containing 17 handwritten documents in Russian was recently discovered in the archives of the Museum of the History of Medicine, First Moscow State Medical University. The letters give a lively account of Sukhanov's everyday observations, experiences and opinions while he was in Van Gehuchten's lab. We took a selection of these notes and put them into medical and historical context., (© 2016 S. Karger AG, Basel.)
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- 2016
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22. Lazar Solomonovich Minor (1855-1942).
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Vein AA
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- Aged, 80 and over, History, 19th Century, History, 20th Century, Humans, Male, Neurology history, Spinal Cord Diseases history
- Published
- 2011
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23. Electromyographic activity in the EEG in Alzheimer's disease: noise or signal?
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van der Hiele K, Reijntjes RH, Vein AA, Westendorp RG, van Buchem MA, Bollen EL, Middelkoop HA, and van Dijk JG
- Abstract
Many efforts have been directed at negating the influence of electromyographic (EMG) activity on the EEG, especially in elderly demented patients. We wondered whether these "artifacts" might reflect cognitive and behavioural aspects of dementia. In this pilot study, 11 patients with probable Alzheimer's disease (AD), 13 with amnestic mild cognitive impairment (MCI) and 13 controls underwent EEG registration. As EMG measures, we used frontal and temporal 50-70 Hz activity. We found that the EEGs of AD patients displayed more theta activity, less alpha reactivity, and more frontal EMG than controls. Interestingly, increased EMG activity indicated more cognitive impairment and more depressive complaints. EEG variables on the whole distinguished better between groups than EMG variables, but an EMG variable was best for the distinction between MCI and controls. Our results suggest that EMG activity in the EEG could be more than noise; it differs systematically between groups and may reflect different cerebral functions than the EEG.
- Published
- 2011
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24. Kozhevnikov epilepsy: the disease and its eponym.
- Author
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Vein AA and van Emde Boas W
- Subjects
- Disease Progression, Encephalitis physiopathology, Encephalitis, Tick-Borne complications, Epilepsia Partialis Continua etiology, Epilepsia Partialis Continua physiopathology, History, 19th Century, Humans, Neurology history, Russia, Seizures etiology, Epilepsia Partialis Continua history
- Abstract
Eponyms continue to have their place in medicine but there are pitfalls associated with their use. "Priorities" may be debatable, misattributions are not uncommon, and knowledge of the original papers is often insufficient. A. Ya. Kozhevnikov (1836-1902) is considered to be the founder of the Russian neurology, best known in the West for his work on epilepsia partialis continua (EPC), published in 1894. Kozhevnikov considered various natures for this disorder but thought chronic infectious etiology to be the most probable. Shortly the eponym Kozhevnikov epilepsy was coined and used in clinical practice and writing. Thirty-five years after Kozhevnikov's death, in 1937, a new form of viral encephalitis, Russian spring-summer tick-borne encephalitis (RTBE), was discovered, which was strongly associated with EPC and at times incorrectly attributed to Kozhevnikov by Russian (Soviet) and West-European scientists, although he never specifically identified or even could have recognized this disease entity. When, in 1958, Canadian scientists published about persisting focal epilepsy due to chronic focal encephalitis in children, a new disease was proclaimed: Rasmussen syndrome or Rasmussen chronic encephalitis. The only reference to Kozhevnikov in the Canadian papers was the incorrect suggestion that Kozhevnikov himself described EPC in RTBE. This historical error resulted in continuing misquotations of Kozhevnikov in the current literature and controversies concerning the place of Kozhevnikov epilepsy in the Classification Scheme of the International League Against Epilepsy (ILAE). The history of Kozhevnikov epilepsy thereby offers an illustrative example of the successive misunderstandings, errors, and controversies that arise due to insufficient knowledge or understanding of the original publications, questionable post hoc interpretations of earlier findings, misquoting of secondary papers, or a combination of all these., (Wiley Periodicals, Inc. © 2010 International League Against Epilepsy.)
- Published
- 2011
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25. Jean-Martin Charcot at the birth of Russian neurology.
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Vein AA
- Subjects
- History, 19th Century, Humans, Russia, Neurology history, Psychiatry history
- Abstract
Russian neurology was virtually nonexistent in the middle of the 19th century which made a traineeship abroad an absolute necessity. Charcot and his school did not just offer professional training, but created the best minds, which would determine the direction of neurology and psychiatry in Russia for many decades. After returning home, young Russian doctors not only implemented everything they had learned in Western Europe, but proceeded to make their own original contributions. The most talented pupils of Charcot, including such prominent names as Kozhevnikov, Korsakov, Minor, Bekhterev and Darkshevich, became the founders of neurological schools in Russia. They laid the basis for the further development of neurology and psychiatry. Remarkably, though trained by the same teachers, each of these future 'founding fathers' of these neurological and psychiatric schools followed his own individual path which resulted in an undeniable diversity in Russian neurology and psychiatry during the period of their formation., (Copyright © 2011 S. Karger AG, Basel.)
- Published
- 2011
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26. Late-onset HMSN 2: further evidence of genetic heterogeneity.
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Vein AA
- Subjects
- Biomedical Research history, Charcot-Marie-Tooth Disease genetics, Charcot-Marie-Tooth Disease history, Heredodegenerative Disorders, Nervous System classification, Heredodegenerative Disorders, Nervous System genetics, History, 20th Century, Humans, Neuromuscular Diseases classification, Neuromuscular Diseases genetics, Neuromuscular Diseases history, Russia, USSR, Genetics, Medical history, Heredodegenerative Disorders, Nervous System history, Neurology history
- Published
- 2009
- Full Text
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27. Famous Russian brains: historical attempts to understand intelligence.
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Vein AA and Maat-Schieman ML
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- Autopsy history, Brain Mapping, History, 19th Century, History, 20th Century, Humans, Russia, Brain anatomy & histology, Famous Persons, Intelligence, Neuroanatomy history, Neuropsychology history
- Abstract
Russian scientists are certainly among those who contributed actively to the search for the neuroanatomical basis of exceptional mental capacity and talent. Research into brain anatomy was one of the topics of special interest in various Russian universities. A number of independent reports on the study of famous Russian brains appeared both in Russia and abroad. Collecting and mapping brains of elite Russians in a structured manner began in Moscow in 1924 with the brain of V. I. Lenin. In 1928, the Moscow Brain Research Institute was founded, the collection of which includes the brains of several prominent Russian neuroscientists, including V. M. Bekhterev, G. I. Rossolimo, L. S. Vygotsky and I. P. Pavlov. The fact that the brain of two of the most outstanding scholars of Russian neurology and psychiatry, A. Ya. Kozhevnikov (1836-1902) and S. S. Korsakov (1854-1900), have been studied is largely unknown. A report of the results of this study was published by A. A. Kaputsin in 1925 providing a detailed neuroanatomical assessment of the brains. A considerable weight, a predominance of the left hemisphere and a particularly complex convolution of the frontal and parietal lobes of both brains were reported, the assumption being that these brain parameters can serve as an indicator of mental capacity. The names Kozhevnikov and Korsakov are among those most cherished by Russian neuroscientists; they are also familiar to Western colleagues. The (re)discovery of the records of the brain autopsies is meaningful, maybe not so much from a neuroanatomical point of view as from a historical perspective.
- Published
- 2008
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28. Science and fate: Lina Stern (1878-1968), a neurophysiologist and biochemist.
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Vein AA
- Subjects
- History, 19th Century, History, 20th Century, Humans, USSR, Workforce, Biochemistry history, Blood-Brain Barrier, Neurophysiology history, Prejudice, Women history
- Abstract
Lina Stern (1878-1968), a neurophysiologist and biochemist, was born in Russia. She studied at the University of Geneva, Switzerland, where, after graduating, she conducted original research in physiology and biochemistry. In 1918, Stern was the first woman to be awarded a professional title at the University of Geneva and headed the department of Physiological Chemistry. She is deservedly considered to be one of the first scientists to entertain the concept of a blood-brain barrier. In 1929, Stern founded the Institute of Physiology in Moscow, of which she was director until 1948, when it was discontinued. Under her leadership, multidisciplinary groups of colleagues worked on the problems of the blood-brain and tissue-brain barriers and homeostasis of the brain. In 1939, Stern was elected full member of the Academy of Sciences and became its first female member ever. Most scientists manage to conduct their research by adjusting to the political and social situations surrounding them. Lina Stern did not follow this path. This small woman of complete devotion to science took the drastic decisions that altered her life. Though destiny was not kind to her, Lina Stern did not compromise. Despite a threat of execution, prolonged imprisonment, and exile she was never broken as a scientist and always maintained her dignity.
- Published
- 2008
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29. [Nicolaas Bidloo, the Dutch director of the first hospital in Russia; a 300-year anniversary].
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Vein AA
- Subjects
- History, 18th Century, History, 19th Century, Hospital Administration history, Humans, Netherlands, Russia, Hospitals history, Schools, Medical history
- Abstract
This year marks 300 years since the first Russian hospital opened its doors. The hospital was established by order of Tsar Peter the Great, and its leadership was given to a Dutchman, Nicolaas Bidloo. Bidloo came from a scientifically prominent Dutch family and was a student of Herman Boerhaave. He arrived in Russia as the personal physician of the Tsar Peter the Great. Besides directing the first Russian hospital, Bidloo also founded the first Russian medical school and authored the first Russian textbook on medical studies. In The Netherlands, little is known about Bidloo and his Russian ventures: he is viewed mainly as a nephew of Govard Bidloo, the renowned doctor and rector of Leiden University and author of a famous anatomical atlas. More attention is given to Bidloo in Russia, where he is considered one of the founders of Russian medicine.
- Published
- 2007
30. Prediction of short-term neurological outcome in full-term neonates with hypoxic-ischaemic encephalopathy based on combined use of electroencephalogram and neuro-imaging.
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Leijser LM, Vein AA, Liauw L, Strauss T, Veen S, and Wezel-Meijler Gv
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- Birth Weight, Brain pathology, Cerebral Palsy diagnosis, Female, Follow-Up Studies, Gestational Age, Humans, Infant, Newborn, Male, Pregnancy, Prognosis, Retrospective Studies, Asphyxia Neonatorum diagnosis, Echoencephalography, Electroencephalography, Hypoxia, Brain diagnosis, Magnetic Resonance Imaging, Neurologic Examination
- Abstract
Background: In infants with hypoxic-ischaemic encephalopathy (HIE), prediction of the prognosis is based on clinical, neuro-imaging and neurophysiological parameters., Methods: EEG, cranial ultrasound, MRI and follow-up findings of 23 infants (GA 35-42 weeks) with HIE were studied retrospectively to assess 1) the contribution of ultrasound, MRI and EEG in predicting outcome, 2) the accuracy of ultrasound as compared to MRI, and 3) whether patterns of brain damage and EEG findings are associated., Results: An abnormal EEG background pattern was highly predictive of adverse outcome [positive predictive value (PPV) 0.88]. If combined with diffuse white and deep and/or cortical grey matter changes on ultrasound or MRI, the PPV increased to 1.00. Abnormal neuro-imaging findings were also highly predictive of adverse outcome. Abnormal signal intensity in the posterior limb of the internal capsule, and diffuse cortical grey matter damage were associated with adverse outcome. MRI showed deep grey matter changes more frequently than ultrasound. Severely abnormal neuro-imaging findings were always associated with abnormal EEG background pattern., Conclusions: Both early EEG and neuro-imaging findings are predictive of outcome in infants with HIE. The predictive value of EEG is strengthened by neuro-imaging.
- Published
- 2007
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31. EEG correlates in the spectrum of cognitive decline.
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van der Hiele K, Vein AA, Reijntjes RH, Westendorp RG, Bollen EL, van Buchem MA, van Dijk JG, and Middelkoop HA
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- Aged, Aged, 80 and over, Alpha Rhythm, Alzheimer Disease, Cognition, Cognition Disorders diagnosis, Disease Progression, Female, Humans, Language, Male, Memory, Neuropsychological Tests, Severity of Illness Index, Theta Rhythm, Cognition Disorders physiopathology, Cognition Disorders psychology, Electroencephalography
- Abstract
Objective: To investigate relations between EEG measures and performance on tests of global cognition, memory, language and executive functioning., Methods: Twenty-two controls, 18 patients with mild cognitive impairment (MCI) and 16 with probable Alzheimer's disease (AD) underwent neuropsychological and EEG investigations. We used the following EEG measures: theta relative power during eyes closed, alpha reactivity during memory activation (i.e. the percentual decrease in alpha power as compared to eyes closed) and alpha coherence during eyes closed and memory activation., Results: Theta relative power was increased in AD patients as compared with controls (p<0.001) and MCI patients (p<0.01) and related to decreased performance in all cognitive domains. Alpha reactivity was decreased in AD patients as compared with controls (p<0.005) and related to decreased performance on tests of global cognition, memory and executive functioning. Alpha coherence did not differ between groups and was unrelated to cognition., Conclusions: EEG power measures were associated with decreased performance on tests of global cognition, memory, language and executive functioning, while coherence measures were not., Significance: The EEG yielded several power measures related to cognitive functions. These EEG power measures might prove useful in prospective studies aimed at predicting longitudinal cognitive decline and dementia.
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- 2007
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32. EEG and MRI correlates of mild cognitive impairment and Alzheimer's disease.
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van der Hiele K, Vein AA, van der Welle A, van der Grond J, Westendorp RG, Bollen EL, van Buchem MA, van Dijk JG, and Middelkoop HA
- Subjects
- Aged, Aged, 80 and over, Analysis of Variance, Diagnosis, Differential, Humans, Image Processing, Computer-Assisted methods, Middle Aged, Neuropsychological Tests, Regression Analysis, Alzheimer Disease pathology, Alzheimer Disease physiopathology, Cognition Disorders pathology, Cognition Disorders physiopathology, Electroencephalography, Magnetic Resonance Imaging
- Abstract
Objective: To investigate whether cognitive function in the spectrum of normal aging to Alzheimer's disease is better reflected in MRI or EEG measures, or a combination of both., Methods: Cognitive functions were tested in 33 elderly subjects: 10 with probable Alzheimer's disease, 11 with mild cognitive impairment and 12 controls. Structural brain parameters were derived from conventional MRI and a quantitative MR technique called magnetization transfer imaging. The EEG provided measures of brain function. We performed multiple linear regression analyses to relate EEG and MRI parameters to global cognition, memory, language and psychomotor speed., Results: The model showed EEG alpha reactivity during eyes open to be the primary factor associated with global cognition, memory and language skills. Brain atrophy was the primary factor associated with psychomotor speed. Furthermore, EEG alpha reactivity during eyes open explained significant additional variability in psychomotor speed., Conclusion: EEG and MRI are each associated with different aspects of cognitive function and complement each other in their relations to psychomotor speed.
- Published
- 2007
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33. Memory activation reveals abnormal EEG in preclinical Huntington's disease.
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van der Hiele K, Jurgens CK, Vein AA, Reijntjes RH, Witjes-Ané MN, Roos RA, van Dijk G, and Middelkoop HA
- Subjects
- Adult, Alpha Rhythm, Early Diagnosis, Female, Genetic Carrier Screening, Humans, Huntington Disease genetics, Huntington Disease physiopathology, Male, Middle Aged, Neurologic Examination, Neuropsychological Tests, Predictive Value of Tests, Theta Rhythm, Trinucleotide Repeats, Cerebral Cortex physiopathology, Electroencephalography, Huntington Disease diagnosis, Memory, Short-Term physiology
- Abstract
The EEG is potentially useful as a marker of early Huntington's disease (HD). In dementia, the EEG during a memory activation challenge showed abnormalities where the resting EEG did not. We investigated whether memory activation also reveals EEG abnormalities in preclinical HD. Sixteen mutation carriers for HD and 13 nonmutation carriers underwent neurological, neuropsychological, MRI and EEG investigations. The EEG was registered during a rest condition, i.e. eyes closed, and a working memory task. In each condition we determined absolute power in the theta (4-8 Hz) and alpha (8-13 Hz) bands and subsequently calculated relative alpha power. The EEG during eyes closed did not differ between groups. The EEG during memory activation showed less relative alpha power in mutation carriers as compared to nonmutation carriers, even though memory performance was similar [F (1,27) = 10.87; P = 0.003]. Absolute powers also showed less alpha power [F (1,27) = 7.02; P = 0.013] but similar theta power. No correlations were found between absolute and relative alpha power on the one hand and neuropsychological scores, motor scores or number of CAG repeats on the other. In conclusion, memory activation reveals functional brain changes in Huntington's disease before clinical signs become overt.
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- 2007
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34. Memory activation enhances EEG abnormality in mild cognitive impairment.
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van der Hiele K, Vein AA, Kramer CG, Reijntjes RH, van Buchem MA, Westendorp RG, Bollen EL, van Dijk JG, and Middelkoop HA
- Subjects
- Aged, Cognition Disorders complications, Female, Humans, Male, Memory Disorders etiology, Cognition Disorders physiopathology, Diagnosis, Computer-Assisted methods, Electroencephalography methods, Evoked Potentials, Visual, Memory, Memory Disorders physiopathology, Pattern Recognition, Visual
- Abstract
This exploratory study investigated EEG power changes during memory activation in patients with amnestic mild cognitive impairment (MCI). Twelve MCI patients and 16 age-matched controls underwent EEG registration during two conventional EEG conditions ('eyes closed' and 'eyes open') and three memory conditions ('word memory', 'picture memory' and 'animal fluency'). For all conditions, EEG power in the theta (4-8 Hz), lower alpha (8-10.5 Hz) and upper alpha (10.5-13 Hz) bands were expressed as percentile changes compared to 'eyes closed'. MCI patients showed significantly less decrease in the lower alpha band than controls (p=0.04) during picture memory activation. The word memory task showed a trend towards a similar effect (p=0.09). This study suggests that memory activation reveals EEG differences between MCI patients and controls while conventional EEG conditions do not.
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- 2007
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35. The Moscow clinic for nervous diseases - walking along the portraits.
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Vein AA
- Subjects
- History, 19th Century, History, 20th Century, Humans, Moscow, Hospitals, Special history, Hospitals, University history, Nervous System Diseases history, Neurology history
- Abstract
The history of the Clinic for Nervous Diseases of the Moscow University reflects in its entirety the history of the Moscow neurological school itself. A.Ya. Kozhevnikov, the founder of the clinic, was the first professor of neurology in Russia. The clinic opened its doors in 1890 and became the first specialized medical facility in Europe devoted to the treatment of neurological disorders. Kozhevnikov brought up a number of talented followers, who later worked all over Russia, and some of them became in charge of the Clinic for Nervous Diseases. This paper looks into contributions Kozhevnikov, his pupils V.K. Rot, V.A. Muratov, G.I. Rossolimo, E.K. Sepp, and some others who were responsible for the development of the neurological science.
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- 2007
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36. Angelman syndrome: is there a characteristic EEG?
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Laan LA and Vein AA
- Subjects
- Adult, Age Factors, Child, Diagnosis, Differential, Humans, Angelman Syndrome physiopathology, Electroencephalography
- Abstract
Angelman syndrome (AS) is a genetic disorder characterised by severe mental retardation, subtle dysmorphic facial features, a characteristic behavioural phenotype, epileptic seizures and EEG abnormalities. AS can be caused by various genetic mechanisms involving the chromosome 15q11-13 region. Neurophysiological studies report a variety of EEG abnormalities seen in AS patients. The objective of this article was to analyse whether there are characteristic EEG changes in AS, whether this varies with age and what the differential diagnosis is. Most of the authors agree about the existence of three main EEG patterns in AS which may appear in isolation or in various combinations in the same patient. The pattern most frequently observed both in children and in adults has prolonged runs of high amplitude rhythmic 2-3 Hz activity predominantly over the frontal regions with superimposed interictal epileptiform discharges. High amplitude rhythmic 4-6 Hz activity, prominent in the occipital regions, with spikes, which can be facilitated by eye closure, is often seen in children under the age of 12 years. There is no difference in EEG findings in AS patients with or without epileptic seizures. AS patients with a deletion of chromosome 15q11-13 have more prominent EEG abnormalities than patients with other genetic disturbances of the chromosome 15 region. The EEG findings are characteristic of AS when seen in the appropriate clinical context and can help to identify AS patients at an early age when genetic counselling may be particularly important.
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- 2005
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37. Single-fiber EMG in familial hemiplegic migraine.
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Terwindt GM, Kors EE, Vein AA, Ferrari MD, and van Dijk JG
- Subjects
- Adolescent, Adult, Amino Acid Substitution, Calcium Channels genetics, Eyebrows, Female, Hemiplegia physiopathology, Humans, Male, Middle Aged, Migraine with Aura complications, Migraine with Aura genetics, Mutation, Missense, Point Mutation, Single-Blind Method, Sodium-Potassium-Exchanging ATPase genetics, Electromyography methods, Hemiplegia etiology, Migraine with Aura physiopathology
- Abstract
Twelve familial hemiplegic migraine (FHM) patients (6 with the I1811L mutation in CACNA1A, 3 with M731T mutation in ATP1A2, and 3 without known mutations) and 10 control subjects underwent single-fiber EMG. Mean jitter did not differ significantly between patients and control subjects or among patients. No blocking was found. The results suggest that neuromuscular function is normal in FHM.
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- 2004
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38. Somatotropic axis in hypocretin-deficient narcoleptic humans: altered circadian distribution of GH-secretory events.
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Overeem S, Kok SW, Lammers GJ, Vein AA, Frölich M, Meinders AE, Roelfsema F, and Pijl H
- Subjects
- Adult, Aged, Carrier Proteins, Growth Hormone-Releasing Hormone pharmacology, Humans, Injections, Intravenous, Metabolism, Inborn Errors complications, Metabolism, Inborn Errors metabolism, Middle Aged, Narcolepsy etiology, Orexins, Reference Values, Sleep, Circadian Rhythm, Growth Hormone blood, Growth Hormone metabolism, Intracellular Signaling Peptides and Proteins, Narcolepsy metabolism, Neuropeptides deficiency
- Abstract
Narcolepsy is a sleep disorder caused by impaired hypocretin (orexin) neurotransmission. Growth hormone (GH) secretion may be altered in narcolepsy for various reasons. Slow-wave sleep episodes, which are closely associated with GH-secretory events, are more randomly dispersed over 24 h in narcoleptics. Furthermore, hypocretins may inhibit pituitary GH release. We assessed the function of the somatotropic axis in narcolepsy by deconvolving 24-h (10-min sampling interval) plasma GH concentration profiles in seven hypocretin-deficient narcoleptic patients and in seven healthy controls matched for age, sex, and body weight. Both basal and pulsatile GH secretion rate and secretagogue-induced GH release were similar in patients and controls. However, narcoleptics secreted approximately 50% of their total production during the daytime, whereas controls secreted only 25% during the day. Also, the GH output pattern of narcoleptics was significantly less regular. We propose that hypocretin deficiency disrupts the circadian distribution of hypothalamic GH-releasing hormone release in narcoleptic patients to simultaneously cause daytime GH release and promote their propensity to fall asleep during the day.
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- 2003
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39. A Rett patient with a typical Angelman EEG.
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Laan LA and Vein AA
- Subjects
- Angelman Syndrome genetics, Angelman Syndrome physiopathology, Cerebral Cortex physiopathology, Child, DNA Mutational Analysis, DNA-Binding Proteins genetics, Diagnosis, Differential, Epilepsy, Rolandic genetics, Epilepsy, Rolandic physiopathology, Female, Follow-Up Studies, Humans, Methyl-CpG-Binding Protein 2, Rett Syndrome genetics, Rett Syndrome physiopathology, Angelman Syndrome diagnosis, Chromosomal Proteins, Non-Histone, Electroencephalography, Epilepsy, Rolandic diagnosis, Repressor Proteins, Rett Syndrome diagnosis
- Abstract
Purpose: To draw attention to the phenomenon that EEG characteristics of both Angelman syndrome (AS) and Rett syndrome (RS) can be found in the same patient, as evidenced by the description of one case. There are specific EEG patterns in AS patients, in which the most frequently occurring EEG characteristics are rhythmic triphasic 2- to 3-Hz, high-voltage (200-500 microV) activity, mixed with spikes or sharp waves, with a maximum over the frontal regions. EEG changes in RS patients are less specific and can show multifocal, mostly central or centrotemporal epileptiform discharges in combination with slow background activity., Methods: A 6-year-old girl with RS and a proven MECP2 mutation was described., Results: She had an EEG pattern at age 2 years comparable with the clinical diagnosis of RS, and an EEG at age 6 years comparable with an AS EEG., Conclusions: We wish to draw attention to this phenomenon, although there is as yet no evident explanation for it. We advise MECP2 examination in AS patients of unknown genetic etiology whose EEG examinations are/were pathognomonic for AS to exclude RS.
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- 2002
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40. Benign familial infantile convulsions: a clinical study of seven Dutch families.
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Callenbach PM, de Coo RF, Vein AA, Arts WF, Oosterwijk J, Hageman G, ten Houten R, Terwindt GM, Lindhout D, Frants RR, and Brouwer OF
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- Electroencephalography, Epilepsies, Partial diagnosis, Female, Follow-Up Studies, Humans, Infant, Male, Netherlands, Pedigree, Remission, Spontaneous, Spasms, Infantile diagnosis, Epilepsies, Partial genetics, Spasms, Infantile genetics
- Abstract
Benign familial infantile convulsions (BFIC) is a recently identified partial epilepsy syndrome with onset between 3 and 12 months of age. We describe the clinical characteristics and outcome of 43 patients with BFIC from six Dutch families and one Dutch-Canadian family and the encountered difficulties in classifying the syndrome. Four families had a pure BFIC phenotype; in two families BFIC was accompanied by paroxysmal kinesigenic dyskinesias; in one family BFIC was associated with later onset focal epilepsy in older generations. Onset of seizures was between 6 weeks and 10 months, and seizures remitted before the age of 3 years in all patients with BFIC. In all, 29 (67%) of the 43 patients had been treated with anti-epileptic drugs for a certain period of time. BFIC is often not recognized as (hereditary) epilepsy by the treating physician. Seizures often remit shortly after the start of anti-epileptic drugs but, because of the benign course of the syndrome and the spontaneous remission of seizures, patients with low seizure frequency do not necessarily have to be treated. If prescribed, anti-epileptic drugs can probably be withdrawn after 1 or 2 years of seizure freedom.
- Published
- 2002
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41. Clinical aspects of multifocal or generalized tonic dystonia in reflex sympathetic dystrophy.
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van Hilten JJ, van de Beek WJ, Vein AA, van Dijk JG, and Middelkoop HA
- Subjects
- Adolescent, Adult, Dystonia complications, Female, Humans, Male, Middle Aged, Reflex Sympathetic Dystrophy complications, Dystonia physiopathology, Reflex Sympathetic Dystrophy physiopathology
- Abstract
The authors describe 10 patients with reflex sympathetic dystrophy that progressed to a multifocal or generalized tonic dystonia. The neuropsychologic profile was similar to that of other patients with chronic pain, irrespective of its cause. The distribution pattern of dystonia, the stretch reflex abnormalities, and the worsening of dystonia after tactile and auditory stimuli suggest impairment of interneuronal circuits at the brainstem or spinal level. Antibody titers for glutamic acid decarboxylase, tetanus, and Sjögren antigens were all normal.
- Published
- 2001
- Full Text
- View/download PDF
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