4,781 results on '"Veillet A"'
Search Results
2. The PEPSI Exoplanet Transit Survey (PETS). V: New Na D transmission spectra indicate a quieter atmosphere on HD 189733b
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Keles, E., Czesla, S., Poppenhaeger, K., Hauschildt, P., Carroll, T. A., Ilyin, I., Baratella, M., Steffen, M., Strassmeier, K. G., Bonomo, A. S., Gaudi, B. S., Henning, T., Johnson, M. C., Molaverdikhani, K., Nascimbeni, V., Patience, J., Reiners, A., Scandariato, G., Schlawin, E., Shkolnik, E., Sicilia, D., Sozzetti, A., Mallonn, M., Veillet, C., Wang, J., and Yan, F.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Absorption lines from exoplanet atmospheres observed in transmission allow us to study atmospheric characteristics such as winds. We present a new high-resolution transit time-series of HD 189733b, acquired with the PEPSI instrument at the LBT and analyze the transmission spectrum around the Na D lines. We model the spectral signature of the RM-CLV-effect using synthetic PHOENIX spectra based on spherical LTE atmospheric models. We find a Na D absorption signature between the second and third contact but not during the ingress and egress phases, which casts doubt on the planetary origin of the signal. Presupposing a planetary origin of the signal, the results suggest a weak day-to-nightside streaming wind in the order of 0.7 km/s and a moderate super-rotational streaming wind in the order of 3 - 4 km/s, challenging claims of prevailing strong winds on HD 189733b., Comment: Accepted for publication in Monthly Notices of the Royal Astronomical Society
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- 2024
3. Near-Infrared Observations of Outflows and YSOs in the Massive Star-Forming Region AFGL 5180
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Crowe, S., Fedriani, R., Tan, J. C., Whittle, M., Zhang, Y., Garatti, A. Caratti o, Farias, J. P., Gautam, A., Telkamp, Z., Rothberg, B., Grudic, M., Andersen, M., Cosentino, G., Garcia-Lopez, R., Rosero, V., Tanaka, K., Pinna, E., Rossi, F., Miller, D., Agapito, G., Plantet, C., Ghose, E., Christou, J., Power, J., Puglisi, A., Briguglio, R., Brusa, G., Taylor, G., Zhang, X., Mazzoni, T., Bonaglia, M., Esposito, S., and Veillet, C.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
Methods: Broad- and narrow-band imaging of AFGL 5180 was made in the NIR with the LBT, in both seeing-limited ($\sim0.5\arcsec$) and high angular resolution ($\sim0.09\arcsec$) Adaptive Optics (AO) modes, as well as with HST. Archival ALMA continuum data was also utilized. Results: At least 40 jet knots were identified via NIR emission from H$_2$ and [FeII] tracing shocked gas. Bright jet knots outflowing from the central most massive protostar, S4, are detected towards the east of the source and are resolved in fine detail with the AO imaging. Additional knots are distributed throughout the field, likely indicating the presence of multiple driving sources. Sub-millimeter sources detected by ALMA are shown to be grouped in two main complexes, AFGL 5180 M and a small cluster $\sim15\arcsec$ to the south, AFGL 5180 S. From our NIR continuum images we identify YSO candidates down to masses of $\sim 0.1\:M_\odot$. Combined with the sub-mm sources, this yields a surface number density of such YSOs of $N_* \sim 10^3 {\rm pc}^{-2}$ within a projected radius of about 0.1 pc. Such a value is similar to those predicted by models of both Core Accretion from a turbulent clump environment and Competitive Accretion. The radial profile of $N_*$ is relatively flat on scales out to 0.2~pc, with only modest enhancement around the massive protostar inside 0.05~pc. Conclusions: This study demonstrates the utility of high-resolution NIR imaging, in particular with AO, for detecting outflow activity and YSOs in distant regions. The presented images reveal the complex morphology of outflow-shocked gas within the large-scale bipolar flow of a massive protostar, as well as clear evidence for several other outflow driving sources in the region. Finally, this work presents a novel approach to compare the observed YSO surface number density from our study against different models of massive star formation., Comment: Accepted to Astronomy & Astrophysics (A&A)
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- 2023
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4. An extensively validated C/H/O/N chemical network for hot exoplanet disequilibrium chemistry
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Veillet, R., Venot, O., Sirjean, B., Bounaceur, R., Glaude, P-A., Al-Refaie, A., and Hébrard, E.
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Astrophysics - Earth and Planetary Astrophysics ,Physics - Atmospheric and Oceanic Physics ,Physics - Chemical Physics - Abstract
We aimed to build a new and updated C0-C2 chemical network to study the CHON disequilibrium chemistry of warm and hot exoplanet atmospheres that relies on extensively validated and recent state-of-the-art combustion networks. The reliability range of this network was aimed for conditions between 500 - 2500 K and 100 - 10^-6 bar. We compared the predictions of seven networks over a large set of experiments, covering a wide range of conditions (pressures, temperatures, and initial compositions). To examine the consequences of this new chemical network on exoplanets atmospheric studies, we generated abundances profiles for GJ 436 b, GJ 1214 b, HD 189733 b, and HD 209458 b, using the 1D kinetic model FRECKLL and calculated the corresponding transmission spectra using TauREx 3.1. These spectra and abundance profiles have been compared with results obtained with our previous chemical network. Our new kinetic network is composed of 174 species and 1293 reactions mostly reversible. This network proves to be more accurate than our previous one for the tested experimental conditions. The nitrogen chemistry update is found to be impactful on the abundance profiles, particularly for HCN, with differences up to four orders of magnitude. The CO2 profiles are also significantly affected, with important repercussions on the transmission spectrum of GJ 436 b. These effects highlight the importance of using extensively validated chemical networks to gain confidence in our models predictions. As shown with CH2NH, the coupling between carbon and nitrogen chemistry combined with radicals produced by photolysis can have huge effects impacting the transmission spectra., Comment: 26 pages, 33 figures. Accepted for publication in Astronomy & Astrophysics
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- 2023
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5. Efficacy of oral 20-hydroxyecdysone (BIO101), a MAS receptor activator, in adults with severe COVID-19 (COVA): a randomized, placebo-controlled, phase 2/3 trial.
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Lobo, Suzana, Plantefève, Gaétan, Nair, Girish, Joaquim Cavalcante, Adilson, Franzin de Moraes, Nara, Nunes, Estevao, Barnum, Otis, Berdun Stadnik, Claudio, Lima, Maria, Lins, Muriel, Hajjar, Ludhmila, Lipinski, Christopher, Islam, Shaheen, Ramos, Fabiano, Simon, Tiago, Martinot, Jean-Benoît, Guimard, Thomas, Desclaux, Arnaud, Lioger, Bertrand, Neuenschwander, Fernando, DeSouza Paolino, Bruno, Acosta, Samuel, Dilling, Daniel, Cartagena, Edgardo, Snyder, Brian, Devaud, Edouard, Barreto Berselli Marinho, Ana, Tanni, Suzana, Milhomem Beato, Patricia, De Wit, Stephan, Selvan, Vani, Gray, Jeffrey, Fernandez, Ricardo, Pourcher, Valérie, Maddox, Lee, Kay, Richard, Azbekyan, Anait, Chabane, Mounia, Tourette, Cendrine, Esmeraldino, Luis, Dilda, Pierre, Lafont, René, Mariani, Jean, Camelo, Serge, Rabut, Sandrine, Agus, Samuel, Veillet, Stanislas, Dioh, Waly, van Maanen, Rob, Morelot-Panzini, Capucine, and Amin, Alpesh
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20-Hydroxyecdysone ,COVID-19 ,MasR ,Renin-angiotensin-system (RAS) ,Respiratory failure ,SARS-CoV-2 - Abstract
BACKGROUND: SARS-CoV-2 binding to ACE2 is potentially associated with severe pneumonia due to COVID-19. The aim of the study was to test whether Mas-receptor activation by 20-hydroxyecdysone (BIO101) could restore the Renin-Angiotensin System equilibrium and limit the frequency of respiratory failure and mortality in adults hospitalized with severe COVID-19. METHODS: Double-blind, randomized, placebo-controlled phase 2/3 trial. Randomization: 1:1 oral BIO101 (350 mg BID) or placebo, up to 28 days or until an endpoint was reached. Primary endpoint: mortality or respiratory failure requiring high-flow oxygen, mechanical ventilation, or extra-corporeal membrane oxygenation. Key secondary endpoint: hospital discharge following recovery (ClinicalTrials.gov Number, NCT04472728). FINDINGS: Due to low recruitment the planned sample size of 310 was not reached and 238 patients were randomized between August 26, 2020 and March 8, 2022. In the modified ITT population (233 patients; 126 BIO101 and 107 placebo), respiratory failure or early death by day 28 was 11.4% lower in the BIO101 (13.5%) than in the placebo (24.3%) group, (p = 0.0426). At day 28, proportions of patients discharged following recovery were 80.1%, and 70.9% in the BIO101 and placebo group respectively, (adjusted difference 11.0%, 95% CI [-0.4%, 22.4%], p = 0.0586). Hazard Ratio for time to death over 90 days: 0.554 (95% CI [0.285, 1.077]), a 44.6% mortality reduction in the BIO101 group (not statistically significant). Treatment emergent adverse events of respiratory failure were more frequent in the placebo group. INTERPRETATION: BIO101 significantly reduced the risk of death or respiratory failure supporting its use in adults hospitalized with severe respiratory symptoms due to COVID-19. FUNDING: Biophytis.
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- 2024
6. The PEPSI Exoplanet Transit Survey. III: The detection of FeI, CrI and TiI in the atmosphere of MASCARA-1 b through high-resolution emission spectroscopy
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Scandariato, G., Borsa, F., Bonomo, A. S., Gaudi, B. S., Henning, Th., Ilyin, I., Johnson, M. C., Malavolta, L., Mallonn, M., Molaverdikhani, K., Nascimbeni, V., Patience, J., Pino, L., Poppenhaeger, K., Schlawin, E., Shkolnik, E. L., Sicilia, D., Sozzetti, A., Strassmeier, K. G., Veillet, C., Wang, J., and Yan, F.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Hot giant planets like MASCARA-1 b are expected to have thermally inverted atmospheres, that makes them perfect laboratory for the atmospheric characterization through high-resolution spectroscopy. Nonetheless, previous attempts of detecting the atmosphere of MASCARA-1 b in transmission have led to negative results. In this paper we aim at the detection of the optical emission spectrum of MASCARA-1 b. We used the high-resolution spectrograph PEPSI to observe MASCARA-1 (spectral type A8) near the secondary eclipse of the planet. We cross-correlated the spectra with synthetic templates computed for several atomic and molecular species. We obtained the detection of FeI, CrI and TiI in the atmosphere of MASCARA-1 b with a S/N ~7, 4 and 5 respectively, and confirmed the expected systemic velocity of ~13 km/s and the radial velocity semi-amplitude of MASCARA-1 b of ~200 km/s. The detection of Ti is of particular importance in the context of the recently proposed Ti cold-trapping below a certain planetary equilibrium temperature. We confirm the presence of an the atmosphere around MASCARA-1 b through emission spectroscopy. We conclude that the atmospheric non detection in transmission spectroscopy is due to the high gravity of the planet and/or to the overlap between the planetary track and its Doppler shadow.
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- 2023
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7. Io's Optical Aurorae in Jupiter's Shadow
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Schmidt, Carl, Sharov, Mikhail, de Kleer, Katherine, Schneider, Nick, de Pater, Imke, Phipps, Phillip H., Conrad, Albert, Moore, Luke, Withers, Paul, Spencer, John, Morgenthaler, Jeff, Ilyin, Ilya, Strassmeier, Klaus, Veillet, Christian, Hill, John, and Brown, Mike
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Astrophysics - Earth and Planetary Astrophysics ,Physics - Space Physics - Abstract
Decline and recovery timescales surrounding eclipse are indicative of the controlling physical processes in Io's atmosphere. Recent studies have established that the majority of Io's molecular atmosphere, SO2 and SO, condenses during its passage through Jupiter's shadow. The eclipse response of Io's atomic atmosphere is less certain, having been characterized solely by ultraviolet aurorae. Here we explore the response of optical aurorae for the first time. We find oxygen to be indifferent to the changing illumination, with [O I] brightness merely tracking the plasma density at Io's position in the torus. In shadow, line ratios confirm sparse SO2 coverage relative to O, since their collisions would otherwise quench the emission. Io's sodium aurora mostly disappears in eclipse and e-folding timescales, for decline and recovery differ sharply: ~10 minutes at ingress and nearly 2 hr at egress. Only ion chemistry can produce such a disparity; Io's molecular ionosphere is weaker at egress due to rapid recombination. Interruption of a NaCl+ photochemical pathway best explains Na behavior surrounding eclipse, implying that the role of electron impact ionization is minor relative to photons. Auroral emission is also evident from potassium, confirming K as the major source of far red emissions seen with spacecraft imaging at Jupiter. In all cases, direct electron impact on atomic gas is sufficient to explain the brightness without invoking significant dissociative excitation of molecules. Surprisingly, the nonresponse of O and rapid depletion of Na is opposite the temporal behavior of their SO2 and NaCl parent molecules during Io's eclipse phase.
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- 2023
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8. The SOUL view of IRAS20126+4104. Kinematics and variability of the H$_2$ jet from a massive protostar
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Massi, F., Garatti, A. Caratti o, Cesaroni, R., Sridharan, T. K., Ghose, E., Pinna, E., Beltrán, M. T., Leurini, S., Moscadelli, L., Sanna, A., Agapito, G., Briguglio, R., Christou, J., Esposito, S., Mazzoni, T., Miller, D., Plantet, C., Power, J., Puglisi, A., Rossi, F., Rothberg, B., Taylor, G., and Veillet, C.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We exploit the increased sensitivity of the recently installed AO SOUL at the LBT to obtain new high-spatial-resolution NIR images of the massive young stellar object IRAS20126+4104 and its outflow. We aim to derive the jet proper motions and kinematics, as well as to study its photometric variability by combining the novel performances of SOUL together with previous NIR images. We used both broad-band ($K_{s}$, $K'$) and narrow-band (Br$\gamma$, H2) observations from a number of NIR cameras (UKIRT/UFTI,SUBARU/CIAO,TNG/NICS,LBT/PISCES,and LBT/LUCI1) to derive maps of the continuum and the H$_2$ emission in the 2.12 $\mu$m line. Three sets of images, obtained with AO systems (CIAO,2003; FLAO,2012; SOUL,2020), allowed us to derive the proper motions of a large number of H$_2$ knots along the jet. Photometry from all images was used to study the jet variability. We derived knot proper motions in the range of 1.7-20.3 mas yr$^{-1}$ (i.e. 13-158 km s$^{-1}$ at 1.64 kpc, avg. outflow tangential velocity $\sim$ 80 km s$^{-1}$). The derived knot dynamical age spans a $\sim$ 200-4000 yr interval. A ring-like H$_2$ feature near the protostar location exhibits peculiar kinematics and may represent the outcome of a wide-angle wind impinging on the outflow cavity. Both H$_2$ geometry and velocities agree with those inferred from proper motions of the H$_2$O masers, located at a smaller distance from the protostar. Although the total H$_2$ line emission from the knots does not exhibit time variations at a $\widetilde{>}$ 0.3 mag level, we have found a clear continuum flux variation (radiation scattered by the dust in the cavity opened by the jet) which is anti-correlated between the blue-shifted and red-shifted lobes and may be periodic (with a period of $\sim$ 12-18 yr). We suggest that the continuum variability might be related to inner-disc oscillations which have also caused the jet precession., Comment: 26 pages, 22 figures, 2 mpeg files, accepted by Astronomy & Astrophysics
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- 2023
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9. Characterization of LBT atmospheric and turbulence conditions in the context of ALTA project
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Turchi, A., Masciadri, E., and Veillet, C.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
ALTA project has been active since 2016, providing, at LBT observatory site, forecasts of atmospheric parameters, such as temperature, wind speed and direction, relative humidity and precipitable water vapor, and optical turbulence parameters, such as seeing, wavefront coherence time and isoplanatic angle with the final goal to support nightly the science operation of the LBT. Besides to the forecasts, during the years ALTA has been collecting statistics on the atmospheric conditions which can be used to draw a very accurate characterization of the climatology of the telescope site located on top of Mount Graham, Arizona. Such characterization can be used both for the optimization and calibration of the forecast model and as a reference for a model validation. The climatology of these parameters is conceived to be a further output of ALTA that will be upgraded on the website with time and it will be able to put in evidence trends at short as well as long time scales. In this contribution we present a climatological description of all the atmospheric parameters relevant for ground-based astronomy in order to provide to the scientific community a robust reference of the bserving conditions at LBT. The study is performed using on-site measurements provided by DIMM and atmospheric sensors over several years and made available in the telescope telemetry data., Comment: 14 pages, 14 figures
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- 2022
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10. Disease-driven top predator decline affects mesopredator population genomic structure
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Beer, Marc A., Proft, Kirstin M., Veillet, Anne, Kozakiewicz, Christopher P., Hamilton, David G., Hamede, Rodrigo, McCallum, Hamish, Hohenlohe, Paul A., Burridge, Christopher P., Margres, Mark J., Jones, Menna E., and Storfer, Andrew
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- 2024
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11. The PEPSI Exoplanet Transit Survey (PETS). II. A Deep Search for Thermal Inversion Agents in KELT-20 b/MASCARA-2 b with Emission and Transmission Spectroscopy
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Johnson, Marshall C., Wang, Ji, Asnodkar, Anusha Pai, Bonomo, Aldo S., Gaudi, B. Scott, Henning, Thomas, Ilyin, Ilya, Keles, Engin, Malavolta, Luca, Mallonn, Matthias, Molaverdikhani, Karan, Nascimbeni, Valerio, Patience, Jennifer, Poppenhaeger, Katja, Scandariato, Gaetano, Schlawin, Everett, Shkolnik, Evgenya, Sicilia, Daniela, Sozzetti, Alessandro, Strassmeier, Klaus G., Veillet, Christian, and Yan, Fei
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Recent observations have shown that the atmospheres of ultra hot Jupiters (UHJs) commonly possess temperature inversions, where the temperature increases with increasing altitude. Nonetheless, which opacity sources are responsible for the presence of these inversions remains largely observationally unconstrained. We used LBT/PEPSI to observe the atmosphere of the UHJ KELT-20 b in both transmission and emission in order to search for molecular agents which could be responsible for the temperature inversion. We validate our methodology by confirming previous detections of Fe I in emission at $16.9\sigma$. Our search for the inversion agents TiO, VO, FeH, and CaH results in non-detections. Using injection-recovery testing we set $4\sigma$ upper limits upon the volume mixing ratios for these constituents as low as $\sim1\times10^{-9}$ for TiO. For TiO, VO, and CaH, our limits are much lower than expectations from an equilibrium chemical model, while we cannot set constraining limits on FeH with our data. We thus rule out TiO and CaH as the source of the temperature inversion in KELT-20 b, and VO only if the line lists are sufficiently accurate., Comment: 18 pages, 11 figures. Accepted for publication in AJ
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- 2022
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12. The PEPSI Exoplanet Transit Survey (PETS) I: Investigating the presence of a silicate atmosphere on the super-Earth 55 Cnc e
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Keles, Engin, Mallonn, Matthias, Kitzmann, Daniel, Poppenhaeger, Katja, Hoeijmakers, H. Jens, Ilyin, Ilya, Alexoudi, Xanthippi, Carroll, Thorsten A., Alvarado-Gomez, Julian, Ketzer, Laura, Bonomo, Aldo S., Borsa, Francesco, Gaudi, Scott, Henning, Thomas, Malavolta, Luca, Molaverdikhani, Karan, Nascimbeni, Valerio, Patience, Jennifer, Pino, Lorenzo, Scandariato, Gaetano, Schlawin, Everett, Shkolnik, Evgenya, Sicilia, Daniela, Sozzetti, Alessandro, Foster, Mary G., Veillet, Christian, Wang, Ji, Yan, Fei, and Strassmeier, Klaus G.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
The study of exoplanets and especially their atmospheres can reveal key insights on their evolution by identifying specific atmospheric species. For such atmospheric investigations, high-resolution transmission spectroscopy has shown great success, especially for Jupiter-type planets. Towards the atmospheric characterization of smaller planets, the super-Earth exoplanet 55 Cnc e is one of the most promising terrestrial exoplanets studied to date. Here, we present a high-resolution spectroscopic transit observation of this planet, acquired with the PEPSI instrument at the Large Binocular Telescope. Assuming the presence of Earth-like crust species on the surface of 55 Cnc e, from which a possible silicate-vapor atmosphere could have originated, we search in its transmission spectrum for absorption of various atomic and ionized species such as Fe , Fe+, Ca , Ca+, Mg and K , among others. Not finding absorption for any of the investigated species, we are able to set absorption limits with a median value of 1.9 x RP. In conclusion, we do not find evidence of a widely extended silicate envelope on this super-Earth reaching several planetary radii., Comment: MNRAS, in press
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- 2022
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13. BIO101 stimulates myoblast differentiation and improves muscle function in adult and old mice
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Maria Serova, Blaise Didry‐Barca, Robin Deloux, Anne‐Sophie Foucault, Stanislas Veillet, René Lafont, Pierre J. Dilda, and Mathilde Latil
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20‐hydroxyecdysone (20E) ,Ecdysteroids ,MAS receptor ,Muscle cell differentiation ,Renin–angiotensin–aldosterone system (RAAS) ,Sarcopenia ,Diseases of the musculoskeletal system ,RC925-935 ,Human anatomy ,QM1-695 - Abstract
Abstract Background Muscle aging is associated with a consistent decrease in the ability of muscle tissue to regenerate following intrinsic muscle degradation, injury or overuse. Age‐related imbalance of protein synthesis and degradation, mainly regulated by AKT/mTOR pathway, leads to progressive loss of muscle mass. Maintenance of anabolic and regenerative capacities of skeletal muscles may be regarded as a therapeutic option for sarcopenia and other muscle wasting diseases. Our previous studies have demonstrated that BIO101, a pharmaceutical grade 20‐hydroxyecdysone, increases protein synthesis through the activation of MAS receptor involved in the protective arm of renin‐angiotensin‐aldosterone system. The purpose of the present study was to assess the anabolic and pro‐differentiating properties of BIO101 on C2C12 muscle cells in vitro and to investigate its effects on adult and old mice models in vivo. Methods The effects of BIO101 on C2C12 differentiation were assessed using myogenic transcription factors and protein expression of major kinases of AKT/mTOR pathway by Western blot. The in vivo effects of BIO101 have been investigated in BIO101 orally‐treated (50 mg/kg/day) adult mice (3 months) for 28 days. To demonstrate potential beneficial effect of BIO101 treatment in a sarcopenic mouse model, we use orally treated 22‐month‐old C57Bl6/J mice, for 14 weeks with vehicle or BIO101. Mice body and muscle weight were recorded. Physical performances were assessed using running capacity and muscle contractility tests. Results Anabolic properties of BIO101 were confirmed by the rapid activation of AKT/mTOR, leading to an increase of C2C12 myotubes diameters (+26%, P
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- 2024
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14. Resolving Io's Volcanoes from a Mutual Event Observation at the Large Binocular Telescope
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de Kleer, Katherine, Skrutskie, Michael, Leisenring, Jarron, Davies, Ashley G., Conrad, Al, de Pater, Imke, Resnick, Aaron, Bailey, Vanessa P., Defrère, Denis, Hinz, Phil, Skemer, Andrew, Spalding, Eckhart, Vaz, Amali, Veillet, Christian, and Woodward, Charles E.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Unraveling the geological processes ongoing at Io's numerous sites of active volcanism requires high spatial resolution to, for example, measure the areal coverage of lava flows or identify the presence of multiple emitting regions within a single volcanic center. In de Kleer et al. (2017) we described observations with the Large Binocular Telescope (LBT) during an occultation of Io by Europa at ~6:17 UT on 2015 March 08, and presented a map of the temperature distribution within Loki Patera derived from these data. Here we present emission maps of three other volcanic centers derived from the same observation: Pillan Patera, Kurdalagon Patera, and the vicinity of Ulgen Patera/PV59/N Lerna Regio. The emission is localized by the light curves and resolved into multiple distinct emitting regions in two of the cases. Both Pillan and Kurdalagon Paterae had undergone eruptions in the months prior to our observations, and the location and intensity of the emission is interpreted in the context of the temporal evolution of these eruptions observed from other facilities. The emission from Kurdalagon Patera is resolved into two distinct emitting regions separated by only a few degrees in latitude that were unresolved by Keck observations from the same month.
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- 2021
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15. Lunar-like silicate material forms the Earth quasisatellite (469219) 2016 HO3 Kamo`oalewa
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Sharkey, Benjamin N. L., Reddy, Vishnu, Malhotra, Renu, Thirouin, Audrey, Kuhn, Olga, Conrad, Albert, Rothberg, Barry, Sanchez, Juan A., Thompson, David, and Veillet, Christian
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Little is known about Earth quasi-satellites, a class of near-Earth small solar system bodies that orbit the sun but remain close to the Earth, because they are faint and difficult to observe. Here we use the Large Binocular Telescope (LBT) and the Lowell Discovery Telescope (LDT) to conduct a comprehensive physical characterization of quasi-satellite (469219) Kamo`oalewa and assess its affinity with other groups of near-Earth objects. We find that (469219) Kamo`oalewa rotates with a period of 28.3 (+1.8/-1.3) minutes and displays a reddened reflectance spectrum from 0.4-2.2 microns. This spectrum is indicative of a silicate-based composition, but with reddening beyond what is typically seen amongst asteroids in the inner solar system. We compare the spectrum to those of several material analogs and conclude that the best match is with lunar-like silicates. This interpretation implies extensive space weathering and raises the prospect that Kamo`oalewa could comprise lunar material., Comment: Published in Nature Communications Earth and Environment
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- 2021
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16. Two adjacent NLR genes conferring quantitative resistance to clubroot disease in Arabidopsis are regulated by a stably inherited epiallelic variation
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Antoine Gravot, Benjamin Liégard, Leandro Quadrana, Florian Veillet, Yoann Aigu, Tristan Bargain, Juliette Bénéjam, Christine Lariagon, Jocelyne Lemoine, Vincent Colot, Maria J. Manzanares-Dauleux, and Mélanie Jubault
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methylation ,clubroot ,Plasmodiophora brassicae ,AT5G47260 ,AT5G47280 ,ADR1-L3 ,Botany ,QK1-989 - Abstract
Clubroot caused by the protist Plasmodiophora brassicae is a major disease affecting cultivated Brassicaceae. Using a combination of quantitative trait locus (QTL) fine mapping, CRISPR-Cas9 validation, and extensive analyses of DNA sequence and methylation patterns, we revealed that the two adjacent neighboring NLR (nucleotide-binding and leucine-rich repeat) genes AT5G47260 and AT5G47280 cooperate in controlling broad-spectrum quantitative partial resistance to the root pathogen P. brassicae in Arabidopsis and that they are epigenetically regulated. The variation in DNA methylation is not associated with any nucleotide variation or any transposable element presence/absence variants and is stably inherited. Variations in DNA methylation at the Pb-At5.2 QTL are widespread across Arabidopsis accessions and correlate negatively with variations in expression of the two genes. Our study demonstrates that natural, stable, and transgenerationally inherited epigenetic variations can play an important role in shaping resistance to plant pathogens by modulating the expression of immune receptors.
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- 2024
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17. Challenges in Identifying Artificial Objects in the Near-Earth Object Population: Spectral Characterization of 2020 SO
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Adam Battle, Vishnu Reddy, Juan A. Sanchez, Benjamin Sharkey, Tanner Campbell, Paul Chodas, Al Conrad, Daniel P. Engelhart, James Frith, Roberto Furfaro, Davide Farnocchia, Olga Kuhn, Neil Pearson, Barry Rothberg, Christian Veillet, and Richard Wainscoat
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- 2024
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18. Two adjacent NLR genes conferring quantitative resistance to clubroot disease in Arabidopsis are regulated by a stably inherited epiallelic variation
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Gravot, Antoine, Liégard, Benjamin, Quadrana, Leandro, Veillet, Florian, Aigu, Yoann, Bargain, Tristan, Bénéjam, Juliette, Lariagon, Christine, Lemoine, Jocelyne, Colot, Vincent, Manzanares-Dauleux, Maria J., and Jubault, Mélanie
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- 2024
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19. The peculiar short-duration GRB 200826A and its supernova
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Rossi, A., Rothberg, B., Palazzi, E., Kann, D. A., D'Avanzo, P., Amati, L., Klose, Sylvio, Perego, Albino, Pian, E., Guidorzi, C., Pozanenko, A. S., Savaglio, S., Stratta, G., Agapito, G., Covino, S., Cusano, F., D'Elia, V., De Pasquale, M., Della Valle, M., Kuhn, O., Izzo, L., Loffredo, E., Masetti, N., Melandri, A., Minaev, P. Y., Guelbenzu, A. M. Nicuesa, Paris, D., Paiano, S., Plantet, C., Rossi, F., Salvaterra, R., Schulze, S., Veillet, C., and Volnova, A. A.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Gamma-ray bursts (GRBs) are classified as long and short events. Long GRBs (LGRBs) are associated with the end states of very massive stars, while short GRBs (SGRBs) are linked to the merger of compact objects. GRB 200826A was a peculiar event, because by definition it was a SGRB, with a rest-frame duration of ~ 0.5 s. However, this event was energetic and soft, which is consistent with LGRBs. The relatively low redshift (z = 0.7486) motivated a comprehensive, multi-wavelength follow-up campaign to characterize its host, search for a possible associated supernova (SN), and thus understand the origin of this burst. To this aim we obtained a combination of deep near-infrared (NIR) and optical imaging together with spectroscopy. Our analysis reveals an optical and NIR bump in the light curve whose luminosity and evolution is in agreement with several LGRB-SNe. Analysis of the prompt GRB shows that this event follows the $E_{\rm p,i}-E_{\rm iso}$ relation found for LGRBs. The host galaxy is a low-mass star-forming galaxy, typical for LGRBs, but with one of the highest star-formation rates (SFR), especially with respect to its mass ($\log M_\ast/M_\odot = 8.6$, SFR $\sim 4.0 \,M_\odot$/yr). We conclude that GRB 200826A is a typical collapsar event in the low tail of the duration distribution of LGRBs. These findings support theoretical predictions that events produced by collapsars can be as short as 0.5 s in the host frame and further confirm that duration alone is not an efficient discriminator for the progenitor class of a GRB., Comment: 19 pages, 11 figures, 2 tables. Accepted for publication in ApJ
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- 2021
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20. Searches after Gravitational Waves Using ARizona Observatories (SAGUARO): Observations and Analysis from Advanced LIGO/Virgo's Third Observing Run
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Paterson, K., Lundquist, M. J., Rastinejad, J. C., Fong, W., Sand, D. J., Andrews, J. E., Amaro, R. C., Eskandari, O., Wyatt, S., Daly, P. N., Bradley, H., Zhou-Wright, S., Valenti, S., Yang, S., Christensen, E., Gibbs, A. R., Shelly, F., Bilinski, C., Chomiuk, L., Corsi, A., Drout, M. R., Foley, R. J., Gabor, P., Garnavich, P., Grier, C. J., Hamden, E., Krantz, H., Olszewski, E., Paschalidis, V., Reichart, D., Rest, A., Smith, N., Strader, J., Trilling, D., Veillet, C., Wagner, R. M., and Zabludoff, A.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
With the conclusion of the third observing run for Advanced LIGO/Virgo (O3), we present a detailed analysis of both triggered and serendipitous observations of 17 gravitational wave (GW) events (7 triggered and 10 purely serendipitous) from the Searches After Gravitational-waves Using ARizona Observatories (SAGUARO) program. We searched a total of 4935 deg$^2$ down to a median 5$\sigma$ transient detection depth of 21.1 AB mag using the Mt Lemmon 1.5 m telescope, the discovery engine for SAGUARO. In addition to triggered events within 24~hours, our transient search encompassed a time interval following GW events of $<120$~hrs, providing observations on $\sim$ 1/2 of the events accessible to the Mt Lemmon 1.5 m telescope. We covered 2.1--86\% of the LVC total probability ($P_{\rm total}$) for individual events, with a median $P_{\rm total} \approx 8\%$ within $<120$~hours. Following improvements to our pipeline and the addition of serendipitous observations, we find a total of 7 new optical candidates across 5 GW events which we are unable to rule out after searching for additional information and comparing to kilonova models. Using both publicly available and our own late-time data, we investigated a total of 252 optical candidates for these 17 events, finding only 65\% were followed up in some capacity by the community. Of the total 252 candidates, we are able to rule out an additional 12 previously reported counterpart candidates. In light of these results, we discuss lessons learned from the SAGUARO GW counterpart search. We discuss how community coordination of observations and candidate follow-up, as well as the role of archival data, are crucial to improving the efficiency of follow-up efforts and preventing unnecessary duplication of effort with limited EM resources., Comment: 44 pages, 21 figures, 2 tables, submitted to ApJ
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- 2020
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21. Efficacy of oral 20-hydroxyecdysone (BIO101), a MAS receptor activator, in adults with severe COVID-19 (COVA): a randomized, placebo-controlled, phase 2/3 trial
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Lobo, Suzana Margareth, Plantefève, Gaétan, Nair, Girish, Joaquim Cavalcante, Adilson, Franzin de Moraes, Nara, Nunes, Estevao, Barnum, Otis, Berdun Stadnik, Claudio Marcel, Lima, Maria Patelli, Lins, Muriel, Hajjar, Ludhmila Abrahao, Lipinski, Christopher, Islam, Shaheen, Ramos, Fabiano, Simon, Tiago, Martinot, Jean-Benoît, Guimard, Thomas, Desclaux, Arnaud, Lioger, Bertrand, Neuenschwander, Fernando Carvalho, DeSouza Paolino, Bruno, Amin, Alpesh, Acosta, Samuel Amil, Dilling, Daniel Forde, Cartagena, Edgardo, Snyder, Brian, Devaud, Edouard, Barreto Berselli Marinho, Ana Karolina, Tanni, Suzana, Milhomem Beato, Patricia Medeiros, De Wit, Stephan, Selvan, Vani, Gray, Jeffrey, Fernandez, Ricardo, Pourcher, Valérie, Maddox, Lee, Kay, Richard, Azbekyan, Anait, Chabane, Mounia, Tourette, Cendrine, Esmeraldino, Luis Everton, Dilda, Pierre J., Lafont, René, Mariani, Jean, Camelo, Serge, Rabut, Sandrine, Agus, Samuel, Veillet, Stanislas, Dioh, Waly, van Maanen, Rob, and Morelot-Panzini, Capucine
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- 2024
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22. A Phase 1 study for safety and pharmacokinetics of BIO101 (20‐hydroxyecdysone) in healthy young and older adults
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Waly Dioh, Cendrine Tourette, Susanna Del Signore, Louiza Daudigny, Philippe Dupont, Christine Balducci, Pierre J. Dilda, René Lafont, and Stanislas Veillet
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20‐hydroxyecdysone ,BIO101 ,sarcopenia ,safety ,pharmacokinetics ,older ,Diseases of the musculoskeletal system ,RC925-935 ,Human anatomy ,QM1-695 - Abstract
Abstract Background Sarcopenia is an age‐related skeletal muscle disorder characterized by loss of muscle mass and strength leading to mobility disability. 20‐Hydroxyecdysone (20E) is a polyhydroxylated plant steroid that demonstrates pharmacological effects in many disease animal models including ageing/sarcopenia. BIO101 is a 20E purified investigational drug (≥97%) that previously demonstrated good toxicology profiles in rat and dog. BIO101 is evaluated in healthy young and older adults in a Phase 1 study. Methods This study is a Single Ascending Dose (SAD) followed by a 14‐day Multiple Ascending Dose (MAD). In SAD, BIO101 was administered orally to 16 young adults at doses from 100 to 1400 mg and to 8 older adults (age ≥65 years) at 1400 mg. In MAD, doses of 350 mg once daily (qd), 350 mg twice daily (bid) and 450 mg bid were administered to 10 older adults. The primary objective was to evaluate safety and pharmacokinetics (PK), including dosing of circulating metabolites. Pharmacodynamic effects were investigated with regard to myostatin, procollagen‐III‐amino‐terminal propeptide (PIIINP), myoglobin, creatine‐kinase Muscle Brain (CKMB), renin and aldosterone plasma/serum levels. Results BIO101 showed a good safety profile with only mild to moderate adverse events and a satisfactory pharmacokinetic profile. In SAD, at 100 mg to 1400 mg, mean Cmax and areas under the curve increased less than dose‐proportionally. Mean half‐life was short (2.4–4.9 h), and mean renal clearance was comparable in all doses (4.05–5.05 L/h). Mean plasma exposure was slightly lower in older adults (22% lower for Cmax and 13%–15% lower for AUCs) compared with young subjects. In MAD, 350 and 450 mg bid led to a slight accumulation over 14 days (mean ratio of accumulation [Rac] of 1.31 in both cohorts). Reduction of biomarkers (myoglobin, CK‐MB) mean serum levels (vs. baseline) was observed at 450 mg bid. Two major metabolites of 20E (14‐deoxy‐20‐hydroxyecdysone and 14‐deoxypoststerone) were identified and quantified. Conclusions BIO101 shows a good safety and pharmacokinetic profile that led to the selection of doses for the subsequent interventional clinical trials of Phase 2 in age‐related sarcopenia (SARA‐INT) and Phase 3 in Covid‐19 (COVA).
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- 2023
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23. Vertical distribution of microplastics in a river water column using an innovative sampling method
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Pasquier, Gabriel, Doyen, Périne, Dehaut, Alexandre, Veillet, Guillaume, Duflos, Guillaume, and Amara, Rachid
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- 2023
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24. RAR Inhibitors Display Photo-Protective and Anti-Inflammatory Effects in A2E Stimulated RPE Cells In Vitro through Non-Specific Modulation of PPAR or RXR Transactivation
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Valérie Fontaine, Thinhinane Boumedine, Elodie Monteiro, Mylène Fournié, Gendre Gersende, José-Alain Sahel, Serge Picaud, Stanislas Veillet, René Lafont, Mathilde Latil, Pierre J. Dilda, and Serge Camelo
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N-retinylidene-N-retinylethanolamine (A2E) ,angiogenesis ,inflammation ,norbixin ,nuclear receptor (NR) ,peroxisome proliferator-activated receptor (PPAR) ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
N-retinylidene-N-retinylethanolamine (A2E) has been associated with age-related macular degeneration (AMD) physiopathology by inducing cell death, angiogenesis and inflammation in retinal pigmented epithelial (RPE) cells. It was previously thought that the A2E effects were solely mediated via the retinoic acid receptor (RAR)-α activation. However, this conclusion was based on experiments using the RAR “specific” antagonist RO-41-5253, which was found to also be a ligand and partial agonist of the peroxisome proliferator-activated receptor (PPAR)-γ. Moreover, we previously reported that inhibiting PPAR and retinoid X receptor (RXR) transactivation with norbixin also modulated inflammation and angiogenesis in RPE cells challenged in the presence of A2E. Here, using several RAR inhibitors, we deciphered the respective roles of RAR, PPAR and RXR transactivations in an in vitro model of AMD. We showed that BMS 195614 (a selective RAR-α antagonist) displayed photoprotective properties against toxic blue light exposure in the presence of A2E. BMS 195614 also significantly reduced the AP-1 transactivation and mRNA expression of the inflammatory interleukin (IL)-6 and vascular endothelial growth factor (VEGF) induced by A2E in RPE cells in vitro, suggesting a major role of RAR in these processes. Surprisingly, however, we showed that (1) Norbixin increased the RAR transactivation and (2) AGN 193109 (a high affinity pan-RAR antagonist) and BMS 493 (a pan-RAR inverse agonist), which are photoprotective against toxic blue light exposure in the presence of A2E, also inhibited PPARs transactivation and RXR transactivation, respectively. Therefore, in our in vitro model of AMD, several commercialized RAR inhibitors appear to be non-specific, and we propose that the phototoxicity and expression of IL-6 and VEGF induced by A2E in RPE cells operates through the activation of PPAR or RXR rather than by RAR transactivation.
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- 2024
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25. Adaptive evolution in virulence effectors of the rice blast fungus Pyricularia oryzae.
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Marie Le Naour-Vernet, Florian Charriat, Jérôme Gracy, Sandrine Cros-Arteil, Sébastien Ravel, Florian Veillet, Isabelle Meusnier, André Padilla, Thomas Kroj, Stella Cesari, and Pierre Gladieux
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Immunologic diseases. Allergy ,RC581-607 ,Biology (General) ,QH301-705.5 - Abstract
Plant pathogens secrete proteins called effectors that target host cellular processes to promote disease. Recently, structural genomics has identified several families of fungal effectors that share a similar three-dimensional structure despite remarkably variable amino-acid sequences and surface properties. To explore the selective forces that underlie the sequence variability of structurally-analogous effectors, we focused on MAX effectors, a structural family of effectors that are major determinants of virulence in the rice blast fungus Pyricularia oryzae. Using structure-informed gene annotation, we identified 58 to 78 MAX effector genes per genome in a set of 120 isolates representing seven host-associated lineages. The expression of MAX effector genes was primarily restricted to the early biotrophic phase of infection and strongly influenced by the host plant. Pangenome analyses of MAX effectors demonstrated extensive presence/absence polymorphism and identified gene loss events possibly involved in host range adaptation. However, gene knock-in experiments did not reveal a strong effect on virulence phenotypes suggesting that other evolutionary mechanisms are the main drivers of MAX effector losses. MAX effectors displayed high levels of standing variation and high rates of non-synonymous substitutions, pointing to widespread positive selection shaping the molecular diversity of MAX effectors. The combination of these analyses with structural data revealed that positive selection acts mostly on residues located in particular structural elements and at specific positions. By providing a comprehensive catalog of amino acid polymorphism, and by identifying the structural determinants of the sequence diversity, our work will inform future studies aimed at elucidating the function and mode of action of MAX effectors.
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- 2023
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26. Enhanced Seeing Mode at the LBT: A Method to Significantly Improve Angular Resolution over a 4' x 4' Field of View
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Rothberg, Barry, Christou, Julian C., Miller, Douglas L., Thompson, Dave, Taylor, Gregory E., and Veillet, Christian
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Since 2014, the LBT's First Light Adaptive Optics (FLAO) system has also included a seldom used capability, known as Enhanced Seeing Mode (ESM), that can improve the angular resolution over a 4' x 4' field of view (FOV). In full AO operation, FLAO provides diffraction limited (DL) capabilities over a small (30" x 30") FOV. By comparison, ESM can achieve significantly enhanced resolution, over natural seeing, across a far larger FOV. This improves operational efficiency over standard seeing limited (SL) observations and is applicable across a broader range of scientific targets. ESM uses 11 modes of correction (including tip and tilt) to remove residual aberrations and jitter which significantly improves angular resolution over the full FOV. While this mode does not reach the DL, it can achieve uniform angular resolutions as good as 0".22 over the FOV. Furthermore, it allows for the use of multi-object spectroscopy with R~10,000 or imaging with angular resolution similar to that achieved by the Wide-Field Camera 3 infrared channel on the Hubble Space Telescope, but powered by 11.6 meters of effective aperture in binocular mode. As part of the on-going characterization of ESM, we have demonstrated that even in poor seeing conditions (1".5-2") the image quality delivered to the focal station is improved by factors of 2-3. Here, we present the first results of the characterization of ESM, including systematic tests of the delivered PSF across the FOV as a function of the brightness of, and distance from, the AO Reference Star. We present a range of galactic and extra-galactic targets showing the improvements obtained over a broad range of seeing conditions and propose ESM as a standard observational mode for near-Infrared observations., Comment: AO4ELT6 Conference Proceedings, 10 pages, 6 Figures
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- 2019
27. Carbon Chain Depletion of 2I/Borisov
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Kareta, Theodore, Andrews, Jennifer, Noonan, John W., Harris, Walter M., Smith, Nathan, O'Brien, Patrick, Sharkey, Benjamin N. L., Reddy, Vishnu, Springmann, Alessondra, Lejoly, Cassandra, Volk, Kathryn, Conrad, Albert, and Veillet, Christian
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Astrophysics - Earth and Planetary Astrophysics - Abstract
The composition of comets in the Solar System come in multiple groups thought to encode information about their formation in different regions of the outer protosolar disk. The recent discovery of the second interstellar object, 2I/Borisov, allows for spectroscopic investigations into its gas content and a preliminary classification of it within the Solar System comet taxonomies to test the applicability of planetesimal formation models to other stellar systems. We present spectroscopic and imaging observations from 2019 September 20th to October 26th at the Bok, MMT, and LBT telescopes. We identify CN in the comet's spectrum and set precise upper limits on the abundance of C2 on all dates. We use a Haser model to convert our integrated fluxes to production rates and find Q(CN) = 5.0 +/- 2.0 * 10^24 mol/s on September 20th and Q(CN) = 1.1 - 1.9 * 10^24 mol/s on later dates, both consistent with contemporaneous observations. We set our lowest upper limit on a C2 production rate, Q(C2) < 1.6 * 10^23 mol/s, on October 10th. The measured ratio upper limit for that date, Q(C2)/Q(CN) < 0.095 indicates that 2I/Borisov is strongly in the (carbon chain) 'depleted' taxonomic group. The only comparable Solar System comets have detected ratios near this limit, making 2I/Borisov statistically likely to be more depleted than any known comet. Most 'depleted' comets are Jupiter Family Comets, perhaps indicating a similiarity in formation conditions between the most depleted of the JFCs and 2I/Borisov. More work is needed to understand the applicability of our knowledge of Solar System comet taxonomies onto interstellar objects, and we discuss future work that could help clarify the usefulness of the approach., Comment: 10 pages, 3 figures, in revision at Astrophysical Journal Letters with new data
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- 2019
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28. Searches After Gravitational-waves Using ARizona Observatories (SAGUARO): System Overview and First Results from Advanced LIGO/Virgo's Third Observing Run
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Lundquist, M. J., Paterson, K., Fong, W., Sand, D. J., Andrews, J. E., Shivaei, I., Daly, P. N., Valenti, S., Yang, S., Christensen, E., Gibbs, A. R., Shelly, F., Wyatt, S., Kuhn, O., Amaro, R. C., Arcavi, I., Behroozi, P., Butler, N., Chomiuk, L., Corsi, A., Drout, M. R., Egami, E., Fan, X., Foley, R. J., Frye, B., Gabor, P., Green, E. M., Grier, C. J., Guzman, F., Hamden, E., Howell, D. A., Jannuzi, B. T., Kelly, P., Milne, P., Moe, M., Nugent, A., Olszewski, E., Palazzi, E., Paschalidis, V., Psaltis, D., Reichart, D., Rest, A., Rossi, A., Schroeder, G., Smith, P. S., Smith, N., Spekkens, K., Strader, J., Stark, D. P., Trilling, D., Veillet, C., Wagner, M., Weiner, B., Wheeler, J. C., Williams, G. G., and Zabludoff, A.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We present Searches After Gravitational-waves Using ARizona Observatories (SAGUARO), a comprehensive effort dedicated to the discovery and characterization of optical counterparts to gravitational wave (GW) events. SAGUARO utilizes ground-based facilities ranging from 1.5m to 10m in diameter, located primarily in the Northern Hemisphere. We provide an overview of SAGUARO's telescopic resources, pipeline for transient detection, and database for candidate visualization. We describe SAGUARO's discovery component, which utilizes the $5$~deg$^2$ field-of-view optical imager on the Mt. Lemmon 1.5m telescope, reaching limits of $\approx 21.3$~AB mag while rapidly tiling large areas. We also describe the follow-up component of SAGUARO, used for rapid vetting and monitoring of optical candidates. With the onset of Advanced LIGO/Virgo's third observing run, we present results from the first three SAGUARO searches following the GW events S190408an, S190425z and S190426c, which serve as a valuable proof-of-concept of SAGUARO. We triggered and searched 15, 60 and 60 deg$^{2}$ respectively, 17.6, 1.4 and 41.8 hrs after the initial GW alerts. We covered 7.8, 3.0 and 5.1\% of the total probability within the GW event localizations, reaching 3$\sigma$ limits of 19.8, 21.3 and 20.8 AB mag, respectively. Although no viable counterparts associated with these events were found, we recovered 6 known transients and ruled out 5 potential candidates. We also present Large Binocular Telescope spectroscopy of PS19eq/SN2019ebq, a promising kilonova candidate that was later determined to be a supernova. With the ability to tile large areas and conduct detailed follow-up, SAGUARO represents a significant addition to GW counterpart searches., Comment: 16 pages, 7 figures, 1 table. Accepted to ApJL
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- 2019
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29. Astro2020 Science White Paper: Triggered High-Priority Observations of Dynamic Solar System Phenomena
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Chanover, Nancy, Wong, Michael H., Greathouse, Thomas, Trilling, David, Conrad, Al, de Pater, Imke, Gaidos, Eric, Cartwright, Richard, Lucas, Michael, Meech, Karen, Orton, Glenn, Pinilla-Alonso, Noemi, Sayanagi, Kunio, Schwamb, Megan E., Tiscareno, Matthew, Veillet, Christian, Holler, Bryan, de Kleer, Katherine, Hammel, Heidi, Hendrix, Amanda, Otarola, Angel, Nixon, Conor, Benecchi, Susan, Simon, Amy, Mandt, Kathleen, Verbiscer, Anne, Giles, Rohini, Retherford, Kurt, Fry, Patrick, Bell, James F., Milam, Stefanie, Rivkin, Andy, and Luszcz-Cook, Statia
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Unexpected dynamic phenomena have surprised solar system observers in the past and have led to important discoveries about solar system workings. Observations at the initial stages of these events provide crucial information on the physical processes at work. We advocate for long-term/permanent programs on ground-based and space-based telescopes of all sizes - including Extremely Large Telescopes (ELTs) - to conduct observations of high-priority dynamic phenomena, based on a predefined set of triggering conditions. These programs will ensure that the best initial dataset of the triggering event are taken; separate additional observing programs will be required to study the temporal evolution of these phenomena. While not a comprehensive list, the following are notional examples of phenomena that are rare, that cannot be anticipated, and that provide high-impact advances to our understandings of planetary processes. Examples include: new cryovolcanic eruptions or plumes on ocean worlds; impacts on Jupiter, Saturn, Uranus, or Neptune; extreme eruptions on Io; convective superstorms on Saturn, Uranus, or Neptune; collisions within the asteroid belt or other small-body populations; discovery of an interstellar object passing through our solar system (e.g. 'Oumuamua); and responses of planetary atmospheres to major solar flares or coronal mass ejections., Comment: Astro2020 white paper
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- 2019
30. Pluto's lower atmosphere and pressure evolution from ground-based stellar occultations, 1988-2016
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Meza, E., Sicardy, B., Assafin, M., Ortiz, J. L., Bertrand, T., Lellouch, E., Desmars, J., Forget, F., Bérard, D., Doressoundiram, A., Lecacheux, J., Oliveira, J. Marques, Roques, F., Widemann, T., Colas, F., Vachier, F., Renner, S., Leiva, R., Braga-Ribas, F., Benedetti-Rossi, G., Camargo, J. I. B., Dias-Oliveira, A., Morgado, B., Gomes-Júnior, A. R., Vieira-Martins, R., Behrend, R., Tirado, A. Castro, Duffard, R., Morales, N., Santos-Sanz, P., Jelínek, M., Cunniffe, R., Querel, R., Harnisch, M., Jansen, R., Pennell, A., Todd, S., Ivanov, V. D., Opitom, C., Gillon, M., Jehin, E., Manfroid, J., Pollock, J., Reichart, D. E., Haislip, J. B., Ivarsen, K. M., LaCluyze, A. P., Maury, A., Gil-Hutton, R., Dhillon, V., Littlefair, S., Marsh, T., Veillet, C., Bath, K. -L., Beisker, W., Bode, H. -J., Kretlow, M., Herald, D., Gault, D., Kerr, S., Pavlov, H., Faragó, O., Klös, O., Frappa, E., Lavayssière, M., Cole, A. A., Giles, A. B., Greenhill, J. G., Hill, K. M., Buie, M. W., Olkin, C. B., Young, E. F., Young, L. A., Wasserman, L. H., Devogèle, M., French, R. G., Bianco, F. B., Marchis, F., Brosch, N., Kaspi, S., Polishook, D., Manulis, I., Larbi, M. Ait Moulay, Benkhaldoun, Z., Daassou, A., Azhari, Y. El, Moulane, Y., Broughton, J., Milner, J., Dobosz, T., Bolt, G., Lade, B., Gilmore, A., Kilmartin, P., Allen, W. H., Graham, P. B., Loader, B., McKay, G., Talbot, J., Parker, S., Abe, L., Bendjoya, Ph., Rivet, J. -P., Vernet, D., Di Fabrizio, L., Lorenzi, V., Magazzù, A., Molinari, E., Gazeas, K., Tzouganatos, L., Carbognani, A., Bonnoli, G., Marchini, A., Leto, G., Sanchez, R. Zanmar, Mancini, L., Kattentidt, B., Dohrmann, M., Guhl, K., Rothe, W., Walzel, K., Wortmann, G., Eberle, A., Hampf, D., Ohlert, J., Krannich, G., Murawsky, G., Gährken, B., Gloistein, D., Alonso, S., Román, A., Communal, J. -E., Jabet, F., de Visscher, S., Sérot, J., Janik, T., Moravec, Z., Machado, P., Selva, A., Perelló, C., Rovira, J., Conti, M., Papini, R., Salvaggio, F., Noschese, A., Tsamis, V., Tigani, K., Barroy, P., Irzyk, M., Neel, D., Godard, J. P., Lanoiselée, D., Sogorb, P., Vérilhac, D., Bretton, M., Signoret, F., Ciabattari, F., Naves, R., Boutet, M., De Queiroz, J., Lindner, P., Lindner, K., Enskonatus, P., Dangl, G., Tordai, T., Eichler, H., Hattenbach, J., Peterson, C., Molnar, L. A., and Howell, R. R.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Context. Pluto's tenuous nitrogen (N2) atmosphere undergoes strong seasonal effects due to high obliquity and orbital eccentricity, and has been recently (July 2015) observed by the New Horizons spacecraft. Goals are (i) construct a well calibrated record of the seasonal evolution of surface pressure on Pluto and (ii) constrain the structure of the lower atmosphere using a central flash observed in 2015. Method: eleven stellar occultations by Pluto observed between 2002 and 2016 are used to retrieve atmospheric profiles (density, pressure, temperature) between $\sim$5 km and $\sim$380 km altitude levels (i.e. pressures from about 10 microbar to 10 nanobar). Results: (i) Pressure has suffered a monotonic increase from 1988 to 2016, that is compared to a seasonal volatile transport model, from which tight constraints on a combination of albedo and emissivity of N2 ice are derived; (ii) A central flash observed on 2015 June 29 is consistent with New Horizons REX profiles, provided that (a) large diurnal temperature variations (not expected by current models) occur over Sputnik Planitia and/or (b) hazes with tangential optical depth of about 0.3 are present at 4-7 km altitude levels and/or (c) the nominal REX density values are overestimated by an implausibly large factor of about 20% and/or (d) higher terrains block part of the flash in the Charon facing hemisphere., Comment: 21 pages, 11 figures
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- 2019
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31. Genome Editing Tools for Potato Improvement
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Ravet, Karl, Sevestre, François, Chauvin, Laura, Chauvin, Jean-Eric, Lairy-Joly, Gisèle, Katz, Andrew, Devaux, Pierre, Szydlowski, Nicolas, Gallois, Jean-Luc, Pearce, Stephen, Veillet, Florian, Zhao, Kaijun, editor, Mishra, Rukmini, editor, and Joshi, Raj Kumar, editor
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- 2022
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32. Wild Australian magpies learn to pull intact, not broken, strings to obtain food
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Johnsson, Robin D., Veillet, Papillon S., Connelly, Farley, Endler, John A., Roth, II, Timothy C., and Lesku, John A.
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- 2023
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33. Diversification processes in Gerp's mouse lemur demonstrate the importance of rivers and altitude as biogeographic barriers in Madagascar's humid rainforests
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Tobias van Elst, Dominik Schüßler, Romule Rakotondravony, Valisoa S. T. Rovanirina, Anne Veillet, Paul A. Hohenlohe, Jonah H. Ratsimbazafy, Rodin M. Rasoloarison, Solofonirina Rasoloharijaona, Blanchard Randrianambinina, Miarisoa L. Ramilison, Anne D. Yoder, Edward E. Louis Jr., and Ute Radespiel
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coalescent ,diversification ,Madagascar ,Microcebus ,phylogeography ,RAD sequencing ,Ecology ,QH540-549.5 - Abstract
Abstract Madagascar exhibits exceptionally high levels of biodiversity and endemism. Models to explain the diversification and distribution of species in Madagascar stress the importance of historical variability in climate conditions which may have led to the formation of geographic barriers by changing water and habitat availability. The relative importance of these models for the diversification of the various forest‐adapted taxa of Madagascar has yet to be understood. Here, we reconstructed the phylogeographic history of Gerp's mouse lemur (Microcebus gerpi) to identify relevant mechanisms and drivers of diversification in Madagascar's humid rainforests. We used restriction site associated DNA (RAD) markers and applied population genomic and coalescent‐based techniques to estimate genetic diversity, population structure, gene flow and divergence times among M. gerpi populations and its two sister species M. jollyae and M. marohita. Genomic results were complemented with ecological niche models to better understand the relative barrier function of rivers and altitude. We show that M. gerpi diversified during the late Pleistocene. The inferred ecological niche, patterns of gene flow and genetic differentiation in M. gerpi suggest that the potential for rivers to act as biogeographic barriers depended on both size and elevation of headwaters. Populations on opposite sides of the largest river in the area with headwaters that extend far into the highlands show particularly high genetic differentiation, whereas rivers with lower elevation headwaters have weaker barrier functions, indicated by higher migration rates and admixture. We conclude that M. gerpi likely diversified through repeated cycles of dispersal punctuated by isolation to refugia as a result of paleoclimatic fluctuations during the Pleistocene. We argue that this diversification scenario serves as a model of diversification for other rainforest taxa that are similarly limited by geographic factors. In addition, we highlight conservation implications for this critically endangered species, which faces extreme habitat loss and fragmentation.
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- 2023
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34. ARGOS at the LBT. Binocular laser guided ground layer adaptive optics
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Rabien, S., Angel, R., Barl, L., Beckmann, U., Busoni, L., Belli, S., Bonaglia, M., Borelli, J., Brynnel, J., Buschkamp, P., Cardwel, A., Contursi, A., Connot, C., Davies, R., Deysenroth, M., Durney, O., Eisenhauer, F., Elberich, M., Esposito, S., Frye, B., Gaessler, W., Gasho, V., Gemperlein, H., Genzel, R., Georgiev, I. Y., Green, R., Hart, M., Kohlmann, C., Kulas, M., Lefebvre, M., Mazzoni, T., Noenickx, J., Ott, T., de Xivry, G. Orban, Peter, D., Puglisi, A., Qin, Y., Quirrenbach, A., Raab, W., Rademacher, M., Rahmer, G., Rix, H. W., Rosensteiner, M., Salinari, P., Schwab, C., Sivitilli, A., Steinmetz, M., Storm, J., Veillet, C., Weigelt, G., and Ziegleder, J.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
Having completed its commissioning phase, the Advanced Rayleigh guided Ground-layer adaptive Optics System (ARGOS) facility is coming online for scientific observations at the Large Binocular Telescope (LBT). With six Rayleigh laser guide stars in two constellations and the corresponding wavefront sensing, ARGOS corrects the ground-layer distortions for both LBT 8.4m eyes with their adaptive secondary mirrors. Under regular observing conditions, this set-up delivers a point spread function (PSF) size reduction by a factor of ~2--3 compared to a seeing-limited operation. With the two LUCI infrared imaging and multi-object spectroscopy instruments receiving the corrected images, observations in the near-infrared can be performed at high spatial and spectral resolution. We discuss the final ARGOS technical set-up and the adaptive optics performance. We show that imaging cases with ground-layer adaptive optics (GLAO) are enhancing several scientific programmes, from cluster colour magnitude diagrams and Milky Way embedded star formation, to nuclei of nearby galaxies or extragalactic lensing fields. In the unique combination of ARGOS with the multi-object near-infrared spectroscopy available in LUCI over a 4x4 arcmin field of view, the first scientific observations have been performed on local and high-z objects. Those high spatial and spectral resolution observations demonstrate the capabilities now at hand with ARGOS at the LBT., Comment: 21 pages, 28 figures
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- 2018
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35. Comparison of intraocular lens tilt after capsular sutured scleral fixation with capsular segments versus uneventful cataract surgery.
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Chang-Sotomayor, Meilin, Gϋell, José L., de Rojas Silva, Ma Victoria, Corretger, Xavier, Bandeira, Francisco, Mendez-Mourelle, Andrea, Veillet, Lorea Zurutuza, Adán, Alfredo, and Figueras-Roca, Marc
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- 2024
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36. Hommage à Jean-Marc Jacquier (1949-2021)
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Veillet, Guillaume
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- 2021
37. Hybridization and range expansion in tamarisk beetles (Diorhabda spp.) introduced to North America for classical biological control
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Amanda R. Stahlke, Ellyn V. Bitume, Zeynep A. Özsoy, Dan W. Bean, Anne Veillet, Meaghan I. Clark, Eliza I. Clark, Patrick Moran, Ruth A. Hufbauer, and Paul A. Hohenlohe
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biological control ,de novo genome assembly ,hybridization ,invasion genomics ,RADseq ,range expansion ,Evolution ,QH359-425 - Abstract
Abstract With the global rise of human‐mediated translocations and invasions, it is critical to understand the genomic consequences of hybridization and mechanisms of range expansion. Conventional wisdom is that high genetic drift and loss of genetic diversity due to repeated founder effects will constrain introduced species. However, reduced genetic variation can be countered by behavioral aspects and admixture with other distinct populations. As planned invasions, classical biological control (biocontrol) agents present important opportunities to understand the mechanisms of establishment and spread in a novel environment. The ability of biocontrol agents to spread and adapt, and their effects on local ecosystems, depends on genomic variation and the consequences of admixture in novel environments. Here, we use a biocontrol system to examine the genome‐wide outcomes of introduction, spread, and hybridization in four cryptic species of a biocontrol agent, the tamarisk beetle (Diorhabda carinata, D. carinulata, D. elongata, and D. sublineata), introduced from six localities across Eurasia to control the invasive shrub tamarisk (Tamarix spp.) in western North America. We assembled a de novo draft reference genome and applied RADseq to over 500 individuals across laboratory cultures, the native ranges, and the introduced range. Despite evidence of a substantial genetic bottleneck among D. carinulata in N. America, populations continue to establish and spread, possibly due to aggregation behavior. We found that D. carinata, D. elongata, and D. sublineata hybridize in the field to varying extents, with D. carinata × D. sublineata hybrids being the most abundant. Genetic diversity was greater at sites with hybrids, highlighting potential for increased ability to adapt and expand. Our results demonstrate the complex patterns of genomic variation that can result from introduction of multiple ecotypes or species for biocontrol, and the importance of understanding them to predict and manage the effects of biocontrol agents in novel ecosystems.
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- 2022
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38. Characterizing sarcopenia and sarcopenic obesity in patients aged 65 years and over, at risk of mobility disability: an observational trial (SARA-OBS)
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Fielding, Roger A, primary, Rolland, Yves, additional, Bruyere, Olivier, additional, Desvarieux, Moise, additional, Donini, Lorenzo M, additional, Incalzi, Raffaele Antonelli, additional, Muscaritoli, Maurizio, additional, Tchalla, Achille, additional, Bonnefoy, Marc, additional, Rondanelli, Mariangela, additional, Maanen, Rob van, additional, Mariani, Jean, additional, Margalef, Carole, additional, Signore, Susanna Del, additional, Tourette, Cendrine, additional, Dioh, Waly, additional, and Veillet, Stanislas, additional
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- 2024
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39. Challenges in Identifying Artificial Objects in the Near-Earth Object Population: Spectral Characterization of 2020 SO
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Battle, Adam, primary, Reddy, Vishnu, additional, Sanchez, Juan A., additional, Sharkey, Benjamin, additional, Campbell, Tanner, additional, Chodas, Paul, additional, Conrad, Al, additional, Engelhart, Daniel P., additional, Frith, James, additional, Furfaro, Roberto, additional, Farnocchia, Davide, additional, Kuhn, Olga, additional, Pearson, Neil, additional, Rothberg, Barry, additional, Veillet, Christian, additional, and Wainscoat, Richard, additional
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- 2024
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40. RAR Inhibitors Display Photo-Protective and Anti-Inflammatory Effects in A2E Stimulated RPE Cells In Vitro through Non-Specific Modulation of PPAR or RXR Transactivation
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Fontaine, Valérie, primary, Boumedine, Thinhinane, additional, Monteiro, Elodie, additional, Fournié, Mylène, additional, Gersende, Gendre, additional, Sahel, José-Alain, additional, Picaud, Serge, additional, Veillet, Stanislas, additional, Lafont, René, additional, Latil, Mathilde, additional, Dilda, Pierre J., additional, and Camelo, Serge, additional
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- 2024
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41. Lunar-like silicate material forms the Earth quasi-satellite (469219) 2016 HO3 Kamoʻoalewa
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Benjamin N. L. Sharkey, Vishnu Reddy, Renu Malhotra, Audrey Thirouin, Olga Kuhn, Albert Conrad, Barry Rothberg, Juan A. Sanchez, David Thompson, and Christian Veillet
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Geology ,QE1-996.5 ,Environmental sciences ,GE1-350 - Abstract
The Earth’s most stable quasi-satellite, Kamoʻoalewa, displays an extremely red reflectance spectrum typical of space weathering of lunar-like silicate material which raises the possibility that it is formed of material originating from the Moon
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- 2021
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42. Disease swamps molecular signatures of genetic-environmental associations to abiotic factors in Tasmanian devil ( Sarcophilus harrisii ) populations
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Fraik, Alexandra K., Margres, Mark J., Epstein, Brendan, Barbosa, Soraia, Jones, Menna, Hendricks, Sarah, Schönfeld, Barbara, Stahlke, Amanda R., Veillet, Anne, Hamede, Rodrigo, McCallum, Hamish, Lopez-Contreras, Elisa, Kallinen, Samantha J., Hohenlohe, Paul A., Kelley, Joanna L., and Storfer, Andrew
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- 2020
43. Current Status of the Facility Instrumentation Suite at The Large Binocular Telescope Observatory
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Rothberg, Barry, Kuhn, Olga, Edwards, Michelle L., Hill, John M., Thompson, David, Veillet, Christian, and Wagner, R. Mark
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We review the current status of the facility instrumentation for the Large Binocular Telescope (LBT). The LBT has 2x 8.4m primary mirrors on a single mount with an effective collecting area of 11.8m or 23m when interferometrically combined. The facility instruments are: 1) the Large Binocular Cameras (LBCs), each with a 23'x25' field of view (FOV). The blue and red optimized optical LBCs are mounted at the prime focus of the left and right primary mirrors, respectively. The filter suite of the two LBCs covers 0.3-1.1{\mu}m, including the new TiO (0.78{\mu}m) and CN (0.82{\mu}m) filters; 2) the Multi-Object Double Spectrograph (MODS), two identical optical spectrographs each mounted at a straight through f/15 Gregorian mount. MODS-1 & -2 can do imaging with Sloan filters and medium resolution (R~2000) spectroscopy, each with 24 interchangeable masks (multi-object or longslit) over a 6'x6' FOV. Each MODS is capable of blue (0.32-0.6{\mu}m) and red (0.5-1.05{\mu}m) wavelength only coverage or, using a dichroic, 0.32-1.05{\mu}m coverage; and 3) the two LBT Utility Camera in the Infrared instruments (LUCIs), each mounted at a bent-front Gregorian f/15 port. LUCI-1 & 2 are designed for seeing-limited (4'x4'FOV) and AO (0.5'x0.5' FOV) imaging & spectroscopy over 0.95-2.5{\mu}m with spectroscopic resolutions of R~400-11000, including 32 interchangeable cryogenically cooled masks. All facility instruments are on the LBT and, for the first time, have been on-sky for science. We also report on the first science use of "mixed-mode" (differently paired instruments). While both primary mirrors reside on a single fixed mount, they are capable of operating independently within a defined "co-pointing" limit. This provides users with the additional capability to independently dither each mirror or center observations on two different sets of spatial coordinates within this limit. (ABRIDGED), Comment: Published in Proceedings of the SPIE 9906, Ground-based and Airborne Telescopes VI, 990622 (July 27, 2016). Paper No. 9906-73. 20 pages, 9 Figures
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- 2016
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44. Cardiac computed tomography in the contemporary evaluation of infective endocarditis
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Khalique, Omar K., Veillet-Chowdhury, Mahdi, Choi, Andrew D., Feuchtner, Gudrun, and Lopez-Mattei, Juan
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- 2021
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45. Structure and seasonal variability in fish food webs in a small macrotidal estuary (Canche estuary, Eastern English Channel) based on stable carbon and nitrogen isotope analysis
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Bouaziz, Rym, Le Loc’h, François, Rolet, Céline, Veillet, Guillaume, Munaron, Jean Marie, Rabhi, Khalef, Djebar, Abdellah Borhane, Amara, Rachid, and Ben Rais Lasram, Frida
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- 2021
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46. Developing new drugs that activate the protective arm of the renin–angiotensin system as a potential treatment for respiratory failure in COVID-19 patients
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Latil, Mathilde, Camelo, Serge, Veillet, Stanislas, Lafont, René, and Dilda, Pierre J.
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- 2021
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47. Hunting for planets in the HL Tau disk
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Testi, L., Skemer, A., Henning, Th., Bailey, V., Defrere, D., Hinz, Ph., Leisenring, J., Vaz, A., Esposito, S., Fontana, A., Marconi, A., Skrutskie, M., and Veillet, C.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Earth and Planetary Astrophysics - Abstract
Recent ALMA images of HL Tau show gaps in the dusty disk that may be caused by planetary bodies. Given the young age of this system, if confirmed, this finding would imply very short timescales for planet formation, probably in a gravitationally unstable disk. To test this scenario, we searched for young planets by means of direct imaging in the L'-band using the Large Binocular Telescope Interferometer mid-infrared camera. At the location of two prominent dips in the dust distribution at ~70AU (~0.5") from the central star we reach a contrast level of ~7.5mag. We did not detect any point source at the location of the rings. Using evolutionary models we derive upper limits of ~10-15MJup at <=0.5-1Ma for the possible planets. With these sensitivity limits we should have been able to detect companions sufficiently massive to open full gaps in the disk. The structures detected at mm-wavelengths could be gaps in the distributions of large grains on the disk midplane, caused by planets not massive enough to fully open gaps. Future ALMA observations of the molecular gas density profile and kinematics as well as higher contrast infrared observations may be able to provide a definitive answer., Comment: Accepted for publication on ApJ Letters
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- 2015
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48. Co-phasing the Large Binocular Telescope: status and performance of LBTI/PHASECam
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Defrère, D., Hinz, P., Downey, E., Ashby, D., Bailey, V., Brusa, G., Christou, J., Danchi, W. C., Grenz, P., Hill, J. M., Hoffmann, W. F., Leisenring, J., Lozi, J., McMahon, T., Mennesson, B., Millan-Gabet, R., Montoya, M., Powell, K., Skemer, A., Vaitheeswaran, V., Vaz, A., and Veillet, C.
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The Large Binocular Telescope Interferometer is a NASA-funded nulling and imaging instrument designed to coherently combine the two 8.4-m primary mirrors of the LBT for high-sensitivity, high-contrast, and high-resolution infrared imaging (1.5-13 um). PHASECam is LBTI's near-infrared camera used to measure tip-tilt and phase variations between the two AO-corrected apertures and provide high-angular resolution observations. We report on the status of the system and describe its on-sky performance measured during the first semester of 2014. With a spatial resolution equivalent to that of a 22.8-meter telescope and the light-gathering power of single 11.8-meter mirror, the co-phased LBT can be considered to be a forerunner of the next-generation extremely large telescopes (ELT)., Comment: 8 pages, 5 figures, SPIE Conference proceedings
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- 2015
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49. Anti-Inflammatory Effects and Photo- and Neuro-Protective Properties of BIO203, a New Amide Conjugate of Norbixin, in Development for the Treatment of Age-Related Macular Degeneration (AMD)
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Valérie Fontaine, Christine Balducci, Laurence Dinan, Elodie Monteiro, Thinhinane Boumedine, Mylène Fournié, Vincent Nguyen, Louis Guibout, Justine Clatot, Mathilde Latil, Stanislas Veillet, José-Alain Sahel, René Lafont, Pierre J. Dilda, and Serge Camelo
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A2E ,AMD ,eye ,norbixin-conjugate ,pharmacokinetics ,PPARs ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
9′-cis-norbixin (norbixin/BIO201) protects RPE cells against phototoxicity induced by blue light and N-retinylidene-N-retinylethanolamine (A2E) in vitro and preserves visual functions in animal models of age-related macular degeneration (AMD) in vivo. The purpose of this study was to examine the mode of action and the in vitro and in vivo effects of BIO203, a novel norbixin amide conjugate. Compared to norbixin, BIO203 displays improved stability at all temperatures tested for up to 18 months. In vitro, BIO203 and norbixin share a similar mode of action involving the inhibition of PPARs, NF-κB, and AP-1 transactivations. The two compounds also reduce IL-6, IL-8, and VEGF expression induced by A2E. In vivo, ocular maximal concentration and BIO203 plasma exposure are increased compared to those of norbixin. Moreover, BIO203 administered systemically protects visual functions and retinal structure in albino rats subjected to blue-light illumination and in the retinal degeneration model of Abca4−/− Rdh8−/− double knock-out mice following 6 months of oral complementation. In conclusion, we report here that BIO203 and norbixin share similar modes of action and protective effects in vitro and in vivo. BIO203, with its improved pharmacokinetic and stability properties, could be developed for the treatment of retinal degenerative diseases such as AMD.
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- 2023
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50. Testing the efficacy and safety of BIO101, for the prevention of respiratory deterioration, in patients with COVID-19 pneumonia (COVA study): a structured summary of a study protocol for a randomised controlled trial
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W. Dioh, M. Chabane, C. Tourette, A. Azbekyan, C. Morelot-Panzini, L. A. Hajjar, M. Lins, G. B. Nair, T. Whitehouse, J. Mariani, M. Latil, S. Camelo, R. Lafont, P. J. Dilda, S. Veillet, and S. Agus
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COVID-19 ,SARS-CoV2 ,randomised controlled trial ,Renin Angiotensin System ,Mas receptor ,angiotensin converting enzyme-2 ,Medicine (General) ,R5-920 - Abstract
Abstract Objectives As of December, 1st, 2020, coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2, resulted in more than 1 472 917 deaths worldwide and death toll is still increasing exponentially. Many COVID-19 infected people are asymptomatic or experience moderate symptoms and recover without medical intervention. However, older people and those with comorbid hypertension, diabetes, obesity, or heart disease are at higher risk of mortality. Because current therapeutic options for COVID-19 patients are limited specifically for this elderly population at risk, Biophytis is developing BIO101 (20-hydroxyecdysone, a Mas receptor activator) as a new treatment option for managing patients with SARS-CoV-2 infection at the severe stage. The angiotensin converting enzyme 2 (ACE2) serves as a receptor for SARS-CoV-2. Interaction between ACE2 and SARS-CoV2 spike protein seems to alter the function of ACE2, a key player in the renin-angiotensin system (RAS). The clinical picture of COVID-19 includes acute respiratory distress syndrome (ARDS), cardiomyopathy, multiorgan dysfunction and shock, all of which might result from an imbalance of the RAS. We propose that RAS balance could be restored in COVID-19 patients through MasR activation downstream of ACE2 activity, with 20-hydroxyecdysone (BIO101) a non-peptidic Mas receptor (MasR) activator. Indeed, MasR activation by 20-hydroxyecdysone harbours anti-inflammatory, anti-thrombotic, and anti-fibrotic properties. BIO101, a 97% pharmaceutical grade 20-hydroxyecdysone could then offer a new therapeutic option by improving the respiratory function and ultimately promoting survival in COVID-19 patients that develop severe forms of this devastating disease. Therefore, the objective of this COVA study is to evaluate the safety and efficacy of BIO101, whose active principle is 20-hydroxyecdysone, in COVID-19 patients with severe pneumonia. Trial design Randomized, double-blind, placebo-controlled, multi-centre, group sequential and adaptive which will be conducted in 2 parts. Part 1: Ascertain the safety and tolerability of BIO101 and obtain preliminary indication of the activity of BIO101, in preventing respiratory deterioration in the target population Part 2: Re-assessment of the sample size needed for the confirmatory part 2 and confirmation of the effect of BIO101 observed in part 1 in the target population. The study is designed as group sequential to allow an efficient run-through, from obtaining an early indication of activity to a final confirmation. And adaptive – to allow accumulation of early data and adapt sample size in part 2 in order to inform the final design of the confirmatory part of the trial. Participants Inclusion criteria 1. Age: 45 and above 2. A confirmed diagnosis of COVID-19 infection, within the last 14 days, prior to randomization, as determined by PCR or other approved commercial or public health assay, in a specimen as specified by the test used. 3. Hospitalized, in observation or planned to be hospitalized due to COVID-19 infection symptoms with anticipated hospitalization duration ≥3 days 4. With evidence of pneumonia based on all of the following: a. Clinical findings on a physical examination b. Respiratory symptoms developed within the past 7 days 5. With evidence of respiratory decompensation that started not more than 4 days before start of study medication and present at screening, meeting one of the following criteria, as assessed by healthcare staff: a. Tachypnea: ≥25 breaths per minute b. Arterial oxygen saturation ≤92% c. A special note should be made if there is suspicion of COVID-19-related myocarditis or pericarditis, as the presence of these is a stratification criterion 6. Without a significant deterioration in liver function tests: a. ALT and AST ≤ 5x upper limit of normal (ULN) b. Gamma-glutamyl transferase (GGT) ≤ 5x ULN c. Total bilirubin ≤ 5×ULN 7. Willing to participate and able to sign an informed consent form (ICF). Or, when relevant, a legally authorized representative (LAR) might sign the ICF on behalf of the study participant 8. Female participants should be: at least 5 years post-menopausal (i.e., persistent amenorrhea 5 years in the absence of an alternative medical cause) or surgically sterile; OR a. Have a negative urine pregnancy test at screening b. Be willing to use a contraceptive method as outlined in inclusion criterion 9 from screening to 30 days after last dose. 9. Male participants who are sexually active with a female partner must agree to the use of an effective method of birth control throughout the study and until 3 months after the last administration of the investigational product. (Note: medically acceptable methods of contraception that may be used by the participant and/or partner include combined oral contraceptive, contraceptive vaginal ring, contraceptive injection, intrauterine device, etonogestrel implant, each supplemented with a condom, as well as sterilization and vasectomy). 10. Female participants who are lactating must agree not to breastfeed during the study and up to 14 days after the intervention. 11. Male participants must agree not to donate sperm for the purpose of reproduction throughout the study and until 3 months after the last administration of the investigational product. 12. For France only: Being affiliated with a European Social Security. Exclusion criteria 1. Not needing or not willing to remain in a healthcare facility during the study 2. Moribund condition (death likely in days) or not expected to survive for >7 days – due to other and non-COVID-19 related conditions 3. Participant on invasive mechanical ventilation via an endotracheal tube, or extracorporeal membrane oxygenation (ECMO), or high-flow Oxygen (delivery of oxygen at a flow of ≥16 L/min.). 4. Participant is not able to take medications by mouth (as capsules or as a powder, mixed in water). 5. Disallowed concomitant medication: Consumption of any herbal products containing 20-hydroxyecdysone and derived from Leuzea carthamoides; Cyanotis vaga or Cyanotis arachnoidea is not allowed (e.g. performance enhancing agents). 6. Any known hypersensitivity to any of the ingredients, or excipients of the study medication, BIO101. 7. Renal disease requiring dialysis, or known renal insufficiency (eGFR≤30 mL/min/1.73 m2, based on Cockcroft & Gault formula). 8. In France only: a. Non-affiliation to compulsory French social security scheme (beneficiary or right-holder). b. Being under tutelage or legal guardianship. Participants will be recruited from approximately 30 clinical centres in Belgium, France, the UK, USA and Brazil. Maximum patients’ participation in the study will last 28 days. Follow-up of participants discharged from hospital will be performed through post-intervention phone calls at 14 (± 2) and 60 (± 4) days. Intervention and comparator Two treatment arms will be tested in this study: interventional arm 350 mg b.i.d. of BIO101 (AP 20-hydroxyecdysone) and placebo comparator arm 350 mg b.i.d of placebo. Administration of daily dose is the same throughout the whole treatment period. Participants will receive the study medication while hospitalized for up to 28 days or until a clinical endpoint is reached (i.e., ‘negative’ or ‘positive’ event). Participants who are officially discharged from hospital care will no longer receive study medication. Main outcomes Primary study endpoint: The proportion of participants with ‘negative’ events up to 28 days. ‘Negative’ events are defined as respiratory deterioration and all-cause mortality. For the purpose of this study, respiratory deterioration will be defined as any of the following: Requiring mechanical ventilation (including cases that will not be intubated due to resource restrictions and triage). Requiring extracorporeal membrane oxygenation (ECMO). Requiring high-flow oxygen defined as delivery of oxygen at a flow of ≥16 L/min. Only if the primary endpoint is significant at the primary final analysis the following Key secondary endpoints will be tested in that order: Proportion of participants with events of respiratory failure at Day 28 Proportion of participants with ‘positive’ events at Day 28. Proportion of participants with events of all-cause mortality at Day 28 A ‘positive’ event is defined as the official discharge from hospital care by the department due to improvement in participant condition. Secondary and exploratory endpoints: In addition, a variety of functional measures and biomarkers (including the SpO2 / FiO2 ratio, viral load and markers related to inflammation, muscles, tissue and the RAS / MAS pathways) will also be collected. Randomization Randomization is performed using an IBM clinical development IWRS system during the baseline visit. Block-permuted randomization will be used to assign eligible participants in a 1:1 ratio. In part 1, randomization will be stratified by RAS pathway modulator use (yes/no) and co-morbidities (none vs. 1 and above). In Part 2, randomization will be stratified by centre, gender, RAS pathway modulator use (yes/no), co-morbidities (none vs. 1 and above), receiving Continuous Positive Airway Pressure/Bi-level Positive Airway Pressure (CPAP/BiPAP) at study entry (Yes/No) and suspicion of COVID-19 related myocarditis or pericarditis (present or not). Blinding (masking) Participants, caregivers, and the study team assessing the outcomes are blinded to group assignment. All therapeutic units (TU), BIO101 b.i.d. or placebo b.i.d., cannot be distinguished in compliance with the double-blind process. An independent data-monitoring committee (DMC) will conduct 2 interim analyses. A first one based on the data from part 1 and a second from the data from parts 1 and 2. The first will inform about BIO101 safety, to allow the start of recruitment into part 2 followed by an analysis of the efficacy data, to obtain an indication of activity. The second interim analysis will inform about the sample size that will be required for part 2, in order to achieve adequate statistical power. Numbers to be randomised (sample size) Number of participants randomized: up to 465, in total Part 1: 50 (to obtain the proof of concept in COVID-19 patients). Part 2: 310, potentially increased by 50% (up to 465, based on interim analysis 2) (to confirm the effects of BIO101 observed in part 1). Trial Status The current protocol Version is V 10.0, dated on 24.09.2020. The recruitment that started on September 1st 2020 is ongoing and is anticipated to finish for the whole study by March2021. Trial registration The trial was registered before trial start in trial registries: EudraCT , No. 2020-001498-63, registered May 18, 2020; and Clinicaltrials.gov, identifier NCT04472728 , registered July 15, 2020. Full protocol The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol.
- Published
- 2021
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- View/download PDF
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