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3. Analysis of acute COVID-19 including chronic morbidity: protocol for the deep phenotyping National Pandemic Cohort Network in Germany (NAPKON-HAP)

Author

Steinbeis, Fridolin, Thibeault, Charlotte, Steinbrecher, Sarah, Ahlgrimm, Yvonne, Haack, Ira an, August, Dietrich, Balzuweit, Beate, Bellinghausen, Carla, Berger, Sarah, Chaplinskaya-Sobol, Irina, Cornely, Oliver, Doeblin, Patrick, Endres, Matthias, Fink, Claudia, Finke, Carsten, Frank, Sandra, Hanß, Sabine, Hartung, Tim, Hellmuth, Johannes Christian, Herold, Susanne, Heuschmann, Peter, Heyckendorf, Jan, Heyder, Ralf, Hippenstiel, Stefan, Hoffmann, Wolfgang, Kelle, Sebastian Ulrich, Knape, Philipp, Koehler, Philipp, Kretzler, Lucie, Leistner, David Manuel, Lienau, Jasmin, Lorbeer, Roberto, Lorenz-Depiereux, Bettina, Lüttke, Constanze Dorothea, Mai, Knut, Merle, Uta, Meyer-Arndt, Lil Antonia, Miljukov, Olga, Muenchhoff, Maximilian, Müller-Plathe, Moritz, Neuhann, Julia, Neuhauser, Hannelore, Nieters, Alexandra, Otte, Christian, Pape, Daniel, Pinto, Rafaela Maria, Pley, Christina, Pudszuhn, Annett, Reuken, Philipp, Rieg, Siegberg, Ritter, Petra, Rohde, Gernot, Rönnefarth, Maria, Ruzicka, Michael, Schaller, Jens, Schmidt, Anne, Schmidt, Sein, Schwachmeyer, Verena, Schwanitz, Georg, Seeger, Werner, Stahl, Dana, Stobäus, Nicole, Stubbe, Hans Christian, Suttorp, Norbert, Temmesfeld, Bettina, Thun, Sylvia, Triller, Paul, Trinkmann, Frederik, Vadasz, Istvan, Valentin, Heike, Vehreschild, Maria, von Kalle, Christof, von Lilienfeld-Toal, Marie, Weber, Joachim, Welte, Tobias, Wildberg, Christian, Wizimirski, Robert, Zvork, Saskia, Sander, Leif Erik, Vehreschild, Janne, Zoller, Thomas, Kurth, Florian, and Witzenrath, Martin

Published
2024
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6. Staphylococcus aureus surgical site infection rates in 5 European countries

Author

Mellinghoff, Sibylle C., Bruns, Caroline, Albertsmeier, Markus, Ankert, Juliane, Bernard, Louis, Budin, Sofia, Bataille, Camille, Classen, Annika Y., Cornely, Florian B., Couvé-Deacon, Elodie, Fernandez Ferrer, Maria, Fortún, Jesús, Galar, Alicia, Grill, Eva, Guimard, Thomas, Hampl, Jürgen A., Wingen-Heimann, Sebastian, Horcajada, Juan P., Köhler, Felix, Koll, Carolin, Mollar, Joan, Muñoz, Patricia, Pletz, Mathias W., Rutz, Jule, Salmanton-García, Jon, Seifert, Harald, Serracino-Inglott, Ferdinand, Soriano, Alex, Stemler, Jannik, Vehreschild, Janne J., Vilz, Tim O., Naendrup, Jan-Hendrik, Cornely, Oliver A., and Liss, Blasius J.

Published
2023
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7. Prevalence of infectious diseases, immunity to vaccine-preventable diseases and chronic medical conditions among Ukrainian refugees in Germany – A cross sectional study from the German Network University Medicine (NUM)

Author

Brinkmann, Folke, Friedrichs, Anette, Behrens, Georg MN, Behrens, Pia, Berner, Reinhard, Caliebe, Amke, Denkinger, Claudia M., Giesbrecht, Katharina, Gussew, Alexander, Hoffmann, Anna Theresa, Hojenski, Leonhard, Hovardovska, Olga, Dopfer-Jablonka, Alexandra, Kaasch, Achim J., Kobbe, Robin, Kraus, Monika, Lindner, Andreas, Maier, Christoph, Mitrov, Lazar, Nauck, Matthias, de Miranda, Susana Nunes, Scherer, Margarete, Schmiedel, Yvonne, Stahl, Dana, Timmesfeld, Nina, Toepfner, Nicole, Vehreschild, Janne, Wohlgemuth, Walter A., Petersmann, Astrid, and Vehreschild, Maria J.G.T.

Published
2024
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8. The Importance of Being FAIR and FAST – The Clinical Epidemiology and Study Platform of the German Network University Medicine (NUKLEUS)

Author

Krefting, Dagmar, primary, Anton, Gabi, additional, Chaplinskaya-Sobol, Irina, additional, Hanss, Sabine, additional, Hoffmann, Wolfgang, additional, Hopff, Sina M., additional, Kraus, Monika, additional, Lorbeer, Roberto, additional, Lorenz-Depiereux, Bettina, additional, Illig, Thomas, additional, Schäfer, Christian, additional, Schaller, Jens, additional, Stahl, Dana, additional, Valentin, Heike, additional, Heuschmann, Peter, additional, and Vehreschild, Janne, additional

Published
2023
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10. 1280. Geospatial Spread of HIV in the Cologne-Bonn Region, Germany: From 2001 to 2016

Author

Stecher, Melanie, Hoenigl, Martin, Eis-Huebinger, Anna-Maria, Lehmann, Clara, Fätkenheuer, Gerd, Wasmuth, Jan-Christian, Knops, Elena, Metha, Sanjay, Vehreschild, Janne, and Chaillon, Antoine

Subjects
HIV/AIDS, Infectious Diseases, Infection, Good Health and Well Being
Abstract

Abstract Background Geographical targeting of interventions of hotspots of HIV transmission increases the impact of HIV intervention. We combined molecular epidemiology and geospatial analyses to provide insights into the drivers of HIV transmission and the contribution of geographical hot spots to the rapidly evolving local HIV epidemic of Cologne-Bonn. Methods We included 714 HIV-1-infected ART naïve individuals, followed at the University Hospitals Cologne and Bonn between 2001 and 2016. Phylogenetic and network analyses were performed to infer putative relationships. Assortativity index (AI, i.e., shared attributes) and characteristics of genetically linked individuals were analyzed. The geospatial diffusion of the local epidemic (i.e., viral gene flow) was evaluated using a Slatkin-Maddison approach. Geospatial dispersal of local HIV transmission was determined by calculating the average distance between genetically linked individuals (centroids of 3-digit zip code of residency, ArcGIS®). Results Of 714 sequences, 217 (30.4%) had a putative linkage with at least one other sequence, forming 77 clusters (size range: 2–8). Genetically linked individuals were significantly more likely to live in suburban areas (P = 0.035),

Published
2018

11. 1283. Pretreatment HIV-1 Drug Resistance in Transmission Clusters of the Cologne-Bonn Region, Germany

Author

Stecher, Melanie, Hoenigl, Martin, Eis-Huebinger, Anna-Maria, Lehmann, Clara, Fätkenheuer, Gerd, Wasmuth, Jan-Christian, Knops, Elena, Metha, Sanjay, Vehreschild, Janne, and Chaillon, Antoine

Subjects
HIV/AIDS, Infectious Diseases, Infection, Good Health and Well Being
Abstract

Abstract Background In Germany, previous reports have demonstrated transmitted HIV-1 drug resistance mutations (DRM) in 10% of newly diagnosed individuals, affecting treatment failure and the choice of antiretroviral therapy (ART). Here, we sought to understand the molecular epidemiology of HIV DRM transmission throughout the Cologne-Bonn region, an area with one of the highest rate of new HIV infections in Europe (13.7 per 100,000 habitants). Methods We analyzed 714 HIV-1 ART naïve infected individuals diagnosed at the University Hospitals Cologne and Bonn between 2001 and 2016. Screening for DRM was performed according to the Stanford University Genotypic Resistance Interpretation. Shared DRM were defined as any DRM present in genetically linked individuals (1%) (11/51, 21.6%). Nucleoside-and non-nucleoside reverse transcriptase inhibitor (NRTI/NNNRTI) resistance mutations were detected in 49 (7%) and 97 (13.6%) individuals, with the E138A in 29 (4.1%) and K103N in 11 (1.5%) being the most frequent. Frequency of DRM was comparable in clustering and not clustering individuals (17.1% vs. 17.5%). Transmission network analysis indicated that the frequency of DRM in clustering individuals was the highest in PWID (3/7, 42.9%) (Figure 1A). Genetically linked individuals harboring shared DRMs were more likely to live in suburban areas than in Central Cologne (18.8% vs. 8% of clustering sequences with DRM; Figure 1B). Conclusion The rate of DRMs was exceptionally high in the Cologne/Bonn area. Network analysis elucidated frequent cases of shared DRMs among genetically linked individuals, revealing the potential spread of DRMs and the need to prevent onward transmission of DRM in the Cologne-Bonn area. Disclosures M. Hoenigl, Gilead, Basilea, Merck: Speaker’s Bureau, Research grant and Speaker honorarium.

Published
2018

12. All-cause mortality and disease progression in SARS-CoV-2-infected patients with or without antibiotic therapy: an analysis of the LEOSS cohort

Author

Schons, Maximilian J., Caliebe, Amke, Spinner, Christoph D., Classen, Annika Y., Pilgram, Lisa, Ruethrich, Maria M., Rupp, Jan, Nunes de Miranda, Susana M., Römmele, Christoph, Vehreschild, Janne, Jensen, Bjoern-Erik, Vehreschild, Maria, Degenhardt, Christian, Borgmann, Stefan, Hower, Martin, Hanses, Frank, Haselberger, Martina, and Friedrichs, Anette K.

Published
2022
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13. Harmonized procedure coding system for surgical procedures and analysis of surgical site infections (SSI) of five European countries

Author

Mellinghoff, Sibylle C., Bruns, Caroline, Al-Monajjed, Rouvier, Cornely, Florian B., Grosheva, Maria, Hampl, Jürgen A., Jakob, Carolin, Koehler, Felix C., Lechmann, Max, Maged, Bijan, Otto-Lambertz, Christina, Rongisch, Robert, Rutz, Jule, Salmanton-Garcia, Jon, Schlachtenberger, Georg, Stemler, Jannik, Vehreschild, Janne, Wülfing, Sophia, Cornely, Oliver A., and Liss, Blasius J.

Published
2022
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15. Autoreninnen und Autoren

Author

Ahrens, Marit, primary, Al-Batran, Salah-Eddin, additional, Armbrust, Robert, additional, Banek, Séverine, additional, Becker, Sven, additional, Bergmann, Lothar, additional, Bojunga, Jörg, additional, Brümmendorf, Tim Henrik, additional, Brunnberg, Uta, additional, Bug, Gesine, additional, Burger, Michael, additional, Chromik, Jörg, additional, Chun, Felix K.-H., additional, Czauderna, Carolin, additional, Dumoulin, Franz Ludwig, additional, Dreyling, Martin, additional, El-Balat, Ahmed, additional, Ellinger, Jörg, additional, Elsner, Susanne, additional, Enßle, Julius C., additional, Fottner, Christian, additional, Galle, Peter R., additional, Gökbuget, Nicola, additional, Götze, Thorsten Oliver, additional, Halbsguth, Teresa, additional, Höh, Benedikt, additional, Hohenberger, Peter, additional, Hübner, Joachim, additional, Hübner, Jutta, additional, Isfort, Susanne, additional, Kasper, Bernd, additional, Katalinic, Alexander, additional, Kestler, Angelika, additional, Khodamoradi, Yascha, additional, Kleemann, Johannes, additional, Kluth, Luis A., additional, Köhler, Viktoria F., additional, Kollmar, Otto, additional, Koschmieder, Steffen, additional, Lang, Fabian, additional, Makowka, Philipp, additional, Mallmann, Peter, additional, Mallmann-Gottschalk, Nina, additional, Mandel, Philipp, additional, Maurer, Gabriele, additional, Mayer, Arnulf, additional, Meissner, Markus, additional, Menge, Franka, additional, Middeke, Jan Moritz, additional, Miesbach, Wolfgang, additional, Möhler, Markus, additional, Möbus, Volker, additional, Müller, Stefan C., additional, Musholt, Thomas J., additional, Nauck, Friedemann, additional, Oellerich, Thomas, additional, Özistanbullu, Deniz, additional, Porschen, Rainer, additional, Pox, Christian, additional, Richter, Konrad Klaus, additional, Sauerbruch, Tilman, additional, Scheich, Sebastian, additional, Schetelig, . Johannes, additional, Schmidberger, Heinz, additional, Schnürch, Hans-Georg, additional, Sebastian, Martin, additional, Sehouli, Jalid, additional, Seifart, Ulf, additional, Serve, Hubert, additional, Seufferlein, Thomas, additional, Shaid, Shabnam, additional, Soysal, Savas D., additional, Steffen, Björn, additional, Steinbach, Joachim P., additional, Stratmann, Jan A., additional, Tsoukakis, Ioannis, additional, Ullrich, Evelyn, additional, Vehreschild, Janne, additional, Metzler, Ivana von, additional, Wolff, Michael von, additional, Voß, Martin, additional, Wagner, Sebastian, additional, Weber, Matthias M., additional, Wege, Henning, additional, Weis, Joachim, additional, Welte, Maria-Noemi, additional, Wenzel, Mike, additional, Wolf, Timo, additional, and Zurmeyer, David, additional

Published
2022
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16. Estimation of Improvements in Mortality in Spectrum Among Adults With HIV Receiving Antiretroviral Therapy in High-Income Countries

Author

Trickey, Adam, primary, Glaubius, Robert, additional, Pantazis, Nikos, additional, Zangerle, Robert, additional, Wittkop, Linda, additional, Vehreschild, Janne, additional, Grabar, Sophie, additional, Cavassini, Matthias, additional, Teira, Ramon, additional, d’Arminio Monforte, Antonella, additional, Casabona, Jordi, additional, van Sighem, Ard, additional, Jarrin, Inma, additional, Ingle, Suzanne M., additional, Sterne, Jonathan A. C., additional, Imai-Eaton, Jeffrey W., additional, and Johnson, Leigh F., additional

Published
2024
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17. Correction to: All-cause mortality and disease progression in SARS-CoV-2-infected patients with or without antibiotic therapy: an analysis of the LEOSS cohort

Author

Schons, Maximilian J., Caliebe, Amke, Spinner, Christoph D., Classen, Annika Y., Pilgram, Lisa, Ruethrich, Maria M., Rupp, Jan, Nunes de Miranda, Susana M., Römmele, Christoph, Vehreschild, Janne, Jensen, Bjoern-Erik, Vehreschild, Maria, Degenhardt, Christian, Borgmann, Stefan, Hower, Martin, Hanses, Frank, Haselberger, Martina, and Friedrichs, Anette K.

Published
2022
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18. Real-world outcomes of patients with operable renal cell carcinoma from the German translational cancer research consortium (DKTK) network.

Author

Grünwald, Viktor, Thomas, Christian, De Santis, Maria, Gratzke, Christian, Chun, Felix, Mager, Rene, Retz, Margitta, Von Amsberg, Gunhild, Ivanyi, Philipp, Christian, Bolenz, Kübler, Hubert, Hadaschik, Boris A., Hahn, Svenja, Erhard, Ian, Reiter, Bastian, Lablans, Martin, Vehreschild, Janne, Brucker, Daniel, and Maier, Daniel

Published
2024
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20. COVIDAL: A machine learning classifier for digital COVID-19 diagnosis in German hospitals

Author

Bartenschlager, Christina C., primary, Ebel, Stefanie S., additional, Kling, Sebastian, additional, Vehreschild, Janne, additional, Zabel, Lutz T., additional, Spinner, Christoph D., additional, Schuler, Andreas, additional, Heller, Axel R., additional, Borgmann, Stefan, additional, Hoffmann, Reinhard, additional, Rieg, Siegbert, additional, Messmann, Helmut, additional, Hower, Martin, additional, Brunner, Jens O., additional, Hanses, Frank, additional, and Römmele, Christoph, additional

Published
2022
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21. Interventional Antibiotic Treatment Replacing Antibiotic Prophylaxis during Allogeneic Hematopoietic Stem Cell Transplantation Is Safe and Feasible: A Single-Center Analysis

Author

Toenges, Rosa, primary, Lang, Fabian, additional, Ghaffar, Rakhshinda, additional, Schlipfenbacher, Vera, additional, Riemann, Julia, additional, Ajib, Salem, additional, Kouidri, Khouloud, additional, Cremer, Anjali, additional, Bodo, Weber, additional, Nguyen, Thu, additional, Knoch, Antje, additional, Vehreschild, Janne, additional, Serve, Hubert, additional, and Bug, Gesine, additional

Published
2022
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22. Transplantationsmedizin in der Intensivmedizin

Author

Michels, Guido, Ruhparwar, Arjang, Welte, Tobias, Gottlieb, Jens, Teschner, Sven, Burst, Volker, Mertens, Jessica, Stippel, Dirk, Herter-Sprie, Grit, von Bergwelt-Baildon, Michael, Theurich, Sebastian, Vehreschild, Janne, Scheid, Christoph, Chemnitz, Jens, Kochanek, Matthias, Michels, Guido, editor, and Kochanek, Matthias, editor

Published
2011
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23. Infektiologie

Author

Kochanek, Matthias, Michels, Guido, Fätkenheuer, Gerd, Cornely, Oliver, Aurbach, Ute, Seifert, Harald, Gutschow, Christian, Waldschmidt, Dirk, Rybniker, Jan, Skouras, Emmanouil, Vehreschild, Maria J.G.T., Vehreschild, Janne, Michels, Guido, editor, and Kochanek, Matthias, editor

Published
2011
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24. Infektiologie

Author

Kochanek, Matthias, Michels, Guido, Koch, Susann, Fätkenheuer, Gerd, Cornely, Oliver, Aurbach, Ute, Seifert, Harald, Gutschow, Christian, Waldschmitt, Dirk, von Gersdorff, Gero, Rybniker, Jan, Skouras, Emmanouil, Rüping, Maria, Vehreschild, Janne, Michels, Guido, editor, and Kochanek, Matthias, editor

Published
2010
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25. Adaptability of Existing Feasibility Tools for Clinical Study Research Data Platforms.

Author

WITTE, Marie-Louise, SCHONEBERG, Anne, HANSS, Sabine, LABLANS, Martin, VEHRESCHILD, Janne, and KREFTING, Dagmar

Abstract

Introduction The increasing need for secondary use of clinical study data requires FAIR infrastructures, i.e. provide findable, accessible, interoperable and reusable data. It is crucial for data scientists to assess the number and distribution of cohorts that meet complex combinations of criteria defined by the research question. This so-called feasibility test is increasingly offered as a self-service, where scientists can filter the available data according to specific parameters. Early feasibility tools have been developed for biosamples or image collections. They are of high interest for clinical study platforms that federate multiple studies and data types, but they pose specific requirements on the integration of data sources and data protection. Methods Mandatory and desired requirements for such tools were acquired from two user groups -- primary users and staff managing a platform's transfer office. Open Source feasibility tools were sought by different literature search strategies and evaluated on their adaptability to the requirements. Results We identified seven feasibility tools that we evaluated based on six mandatory properties. Discussion We determined five feasibility tools to be most promising candidates for adaption to a clinical study research data platform, the Clinical Communication Platform, the German Portal for Medical Research Data, the Feasibility Explorer, Medical Controlling, and the Sample Locator. [ABSTRACT FROM AUTHOR]

Published
2023
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26. COVID-19 in patients with cirrhosis: insights from the multinational LEOSS registry

Author

Brozat, Jonathan Frederik, primary, Hanses, Frank, additional, Haselberger, Martina, additional, Stecher, Melanie, additional, Dreher, Michael, additional, Tometten, Lukas, additional, Rüthrich, Maria Madeleine, additional, Vehreschild, Janne, additional, Trautwein, Christian, additional, Borgmann, Stefan, additional, Vehreschild, Maria, additional, Jakob, Carolin E.M, additional, Stallmach, Andreas, additional, Wille, Kai, additional, Hellwig, Kerstin, additional, Isberner, Nora, additional, Reuken, Philipp, additional, Geisler, Fabian, additional, Nattermann, Jacob, additional, and Bruns, Tony, additional

Published
2022
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27. Obesity and Impaired Metabolic Health Increase Risk of COVID-19-Related Mortality in Young and Middle-Aged Adults to the Level Observed in Older People: The LEOSS Registry

Author

Stefan, Norbert, primary, Sippel, Katrin, additional, Heni, Martin, additional, Fritsche, Andreas, additional, Wagner, Robert, additional, Jakob, Carolin E. M., additional, Preißl, Hubert, additional, von Werder, Alexander, additional, Khodamoradi, Yascha, additional, Borgmann, Stefan, additional, Rüthrich, Maria Madeleine, additional, Hanses, Frank, additional, Haselberger, Martina, additional, Piepel, Christiane, additional, Hower, Martin, additional, vom Dahl, Jürgen, additional, Wille, Kai, additional, Römmele, Christoph, additional, Vehreschild, Janne, additional, Stecher, Melanie, additional, Solimena, Michele, additional, Roden, Michael, additional, Schürmann, Annette, additional, Gallwitz, Baptist, additional, Hrabe de Angelis, Martin, additional, Ludwig, David S., additional, Schulze, Matthias B., additional, Jensen, Bjoern Erik Ole, additional, and Birkenfeld, Andreas L., additional

Published
2022
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28. All-cause mortality and disease progression in SARS-CoV-2-infected patients with or without antibiotic therapy: an analysis of the LEOSS cohort (vol 8, pg 1, 2021)

Author

Schons, Maximilian J., Caliebe, Amke, Spinner, Christoph D., Classen, Annika Y., Pilgram, Lisa, Ruethrich, Maria M., Rupp, Jan, Nunes de Miranda, Susana M., Roemmele, Christoph, Vehreschild, Janne, Jensen, Bjoern-Erik, Vehreschild, Maria, Degenhardt, Christian, Borgmann, Stefan, Hower, Martin, Hanses, Frank, Haselberger, Martina, Friedrichs, Anette K., Schons, Maximilian J., Caliebe, Amke, Spinner, Christoph D., Classen, Annika Y., Pilgram, Lisa, Ruethrich, Maria M., Rupp, Jan, Nunes de Miranda, Susana M., Roemmele, Christoph, Vehreschild, Janne, Jensen, Bjoern-Erik, Vehreschild, Maria, Degenhardt, Christian, Borgmann, Stefan, Hower, Martin, Hanses, Frank, Haselberger, Martina, and Friedrichs, Anette K.

Published
2022

29. Obesity and Impaired Metabolic Health Increase Risk of COVID-19-Related Mortality in Young and Middle-Aged Adults to the Level Observed in Older People: The LEOSS Registry

Author

Stefan, Norbert, Sippel, Katrin, Heni, Martin, Fritsche, Andreas, Wagner, Robert, Jakob, Carolin E. M., Preissl, Hubert, von Werder, Alexander, Khodamoradi, Yascha, Borgmann, Stefan, Ruethrich, Maria Madeleine, Hanses, Frank, Haselberger, Martina, Piepel, Christiane, Hower, Martin, vom Dahl, Jurgen, Wille, Kai, Roemmele, Christoph, Vehreschild, Janne, Stecher, Melanie, Solimena, Michele, Roden, Michael, Schuermann, Annette, Gallwitz, Baptist, de Angelis, Martin Hrabe, Ludwig, David S., Schulze, Matthias B., Jensen, Bjoern Erik Ole, Birkenfeld, Andreas L., Stefan, Norbert, Sippel, Katrin, Heni, Martin, Fritsche, Andreas, Wagner, Robert, Jakob, Carolin E. M., Preissl, Hubert, von Werder, Alexander, Khodamoradi, Yascha, Borgmann, Stefan, Ruethrich, Maria Madeleine, Hanses, Frank, Haselberger, Martina, Piepel, Christiane, Hower, Martin, vom Dahl, Jurgen, Wille, Kai, Roemmele, Christoph, Vehreschild, Janne, Stecher, Melanie, Solimena, Michele, Roden, Michael, Schuermann, Annette, Gallwitz, Baptist, de Angelis, Martin Hrabe, Ludwig, David S., Schulze, Matthias B., Jensen, Bjoern Erik Ole, and Birkenfeld, Andreas L.

Abstract

Advanced age, followed by male sex, by far poses the greatest risk for severe COVID-19. An unresolved question is the extent to which modifiable comorbidities increase the risk of COVID-19-related mortality among younger patients, in whom COVID-19-related hospitalization strongly increased in 2021. A total of 3,163 patients with SARS-COV-2 diagnosis in the Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS) cohort were studied. LEOSS is a European non-interventional multi-center cohort study established in March 2020 to investigate the epidemiology and clinical course of SARS-CoV-2 infection. Data from hospitalized patients and those who received ambulatory care, with a positive SARS-CoV-2 test, were included in the study. An additive effect of obesity, diabetes and hypertension on the risk of mortality was observed, which was particularly strong in young and middle-aged patients. Compared to young and middle-aged (18-55 years) patients without obesity, diabetes and hypertension (non-obese and metabolically healthy; n = 593), young and middle-aged adult patients with all three risk parameters (obese and metabolically unhealthy; n = 31) had a similar adjusted increased risk of mortality [OR 7.42 (95% CI 1.55-27.3)] as older (56-75 years) non-obese and metabolically healthy patients [n = 339; OR 8.21 (95% CI 4.10-18.3)]. Furthermore, increased CRP levels explained part of the elevated risk of COVID-19-related mortality with age, specifically in the absence of obesity and impaired metabolic health. In conclusion, the modifiable risk factors obesity, diabetes and hypertension increase the risk of COVID-19-related mortality in young and middle-aged patients to the level of risk observed in advanced age.

Published
2022

30. COVID-19 mortality in cirrhosis is determined by cirrhosis-associated comorbidities and extrahepatic organ failure: Results from the multinational LEOSS registry

Author

Brozat, Jonathan F., Hanses, Frank, Haelberger, Martina, Stecher, Melanie, Dreher, Michael, Tometten, Lukas, Ruethrich, Maria M., Vehreschild, Janne J., Trautwein, Christian, Borgmann, Stefan, Vehreschild, Maria J. G. T., Jakob, Carolin E. M., Stallmach, Andreas, Wille, Kai, Hellwig, Kerstin, Isberner, Nora, Reuken, Philipp A., Geisler, Fabian, Nattermann, Jacob, Bruns, Tony, Brozat, Jonathan F., Hanses, Frank, Haelberger, Martina, Stecher, Melanie, Dreher, Michael, Tometten, Lukas, Ruethrich, Maria M., Vehreschild, Janne J., Trautwein, Christian, Borgmann, Stefan, Vehreschild, Maria J. G. T., Jakob, Carolin E. M., Stallmach, Andreas, Wille, Kai, Hellwig, Kerstin, Isberner, Nora, Reuken, Philipp A., Geisler, Fabian, Nattermann, Jacob, and Bruns, Tony

Abstract

Background and Objective International registries have reported high mortality rates in patients with liver disease and COVID-19. However, the extent to which comorbidities contribute to excess COVID-19 mortality in cirrhosis is controversial. Methods We used the multinational Lean European Open Survey on SARS-CoV-2-infected patients (LEOSS) to identify patients with cirrhosis documented between March 2020 and March 2021, when the wild-type and alpha variant were predominant. We compared symptoms, disease progression and mortality after propensity score matching (PSM) for age, sex, obesity, smoking status, and concomitant diseases. Mortality was also compared with that of patients with spontaneous bacterial peritonitis (SBP) without SARS-CoV-2 infection, a common bacterial infection and well-described precipitator of acute-on-chronic liver failure. Results Among 7096 patients with SARS-CoV-2 infection eligible for analysis, 70 (0.99%) had cirrhosis, and all were hospitalized. Risk factors for severe COVID-19, such as diabetes, renal disease, and cardiovascular disease were more frequent in patients with cirrhosis. Case fatality rate in patients with cirrhosis was 31.4% with the highest odds of death in patients older than 65 years (43.6% mortality; odds ratio [OR] 4.02; p = 0.018), Child-Pugh class C (57.1%; OR 4.00; p = 0.026), and failure of two or more organs (81.8%; OR 19.93; p = 0.001). After PSM for demographics and comorbidity, the COVID-19 case fatality of patients with cirrhosis did not significantly differ from that of matched patients without cirrhosis (28.8% vs. 26.1%; p = 0.644) and was similar to the 28-day mortality in a comparison group of patients with cirrhosis and SBP (33.3% vs. 31.5%; p = 1.000). Conclusions In immunologically naive patients with cirrhosis, mortality from wild-type SARS-CoV-2 and the alpha variant is high and is largely determined by cirrhosis-associated comorbidities and extrahepatic organ failure.

Published
2022

31. Interventional Antibiotic Treatment Replacing Antibiotic Prophylaxis during Allogeneic Hematopoietic Stem Cell Transplantation Is Safe and Feasible: A Single-Center Analysis

Author

Toenges, Rosa, Lang, Fabian, Ghaffar, Rakhshinda, Schlipfenbacher, Vera, Riemann, Julia, Ajib, Salem, Kouidri, Khouloud, Cremer, Anjali, Bodo, Weber, Knoch, Antje, Vehreschild, Janne, Serve, Hubert, Bug, Gesine, Toenges, Rosa, Lang, Fabian, Ghaffar, Rakhshinda, Schlipfenbacher, Vera, Riemann, Julia, Ajib, Salem, Kouidri, Khouloud, Cremer, Anjali, Bodo, Weber, Knoch, Antje, Vehreschild, Janne, Serve, Hubert, and Bug, Gesine

Published
2022

32. Additional file 1 of Harmonized procedure coding system for surgical procedures and analysis of surgical site infections (SSI) of five European countries

Author

Mellinghoff, Sibylle C., Bruns, Caroline, Al-Monajjed, Rouvier, Cornely, Florian B., Grosheva, Maria, Hampl, Jürgen A., Jakob, Carolin, Koehler, Felix C., Lechmann, Max, Maged, Bijan, Otto-Lambertz, Christina, Rongisch, Robert, Rutz, Jule, Salmanton-Garcia, Jon, Schlachtenberger, Georg, Stemler, Jannik, Vehreschild, Janne, Wülfing, Sophia, Cornely, Oliver A., and Liss, Blasius J.

Abstract

Additional file 1.

Published
2022
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33. Obesity and Impaired Metabolic Health Increase Risk of COVID-19-Related Mortality in Young and Middle-Aged Adults to the Level Observed in Older People: The LEOSS Registry

Author

Stefan, Norbert, Sippel, Katrin, Heni, Martin, Fritsche, Andreas, Wagner, Robert, Jakob, Carolin E. M., Preißl, Hubert, von Werder, Alexander, Khodamoradi, Yascha, Borgmann, Stefan, Rüthrich, Maria Madeleine, Hanses, Frank, Haselberger, Martina, Piepel, Christiane, Hower, Martin, vom Dahl, Jürgen, Wille, Kai, Römmele, Christoph, Vehreschild, Janne, Stecher, Melanie, Solimena, Michele, Roden, Michael, Schürmann, Annette, Gallwitz, Baptist, Hrabe de Angelis, Martin, Ludwig, David S., Schulze, Matthias B., Jensen, Bjoern Erik Ole, and Birkenfeld, Andreas L.

Subjects
Medicine, obesity, diabetes, hypertension, impaired metabolic health, mortality, COVID-19, ddc
Published
2021

34. Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19

Author

Krämer, Benjamin, primary, Knoll, Rainer, additional, Bonaguro, Lorenzo, additional, ToVinh, Michael, additional, Raabe, Jan, additional, Astaburuaga-García, Rosario, additional, Schulte-Schrepping, Jonas, additional, Kaiser, Kim Melanie, additional, Rieke, Gereon J., additional, Bischoff, Jenny, additional, Monin, Malte B., additional, Hoffmeister, Christoph, additional, Schlabe, Stefan, additional, De Domenico, Elena, additional, Reusch, Nico, additional, Händler, Kristian, additional, Reynolds, Gary, additional, Blüthgen, Nils, additional, Hack, Gudrun, additional, Finnemann, Claudia, additional, Nischalke, Hans D., additional, Strassburg, Christian P., additional, Stephenson, Emily, additional, Su, Yapeng, additional, Gardner, Louis, additional, Yuan, Dan, additional, Chen, Daniel, additional, Goldman, Jason, additional, Rosenstiel, Philipp, additional, Schmidt, Susanne V., additional, Latz, Eicke, additional, Hrusovsky, Kevin, additional, Ball, Andrew J., additional, Johnson, Joe M., additional, Koenig, Paul-Albert, additional, Schmidt, Florian I., additional, Haniffa, Muzlifah, additional, Heath, James R., additional, Kümmerer, Beate M., additional, Keitel, Verena, additional, Jensen, Björn, additional, Stubbemann, Paula, additional, Kurth, Florian, additional, Sander, Leif E., additional, Sawitzki, Birgit, additional, Aschenbrenner, Anna C., additional, Schultze, Joachim L., additional, Nattermann, Jacob, additional, Altmüller, Janine, additional, Angelov, Angel, additional, Bals, Robert, additional, Bartholomäus, Alexander, additional, Becker, Anke, additional, Becker, Matthias, additional, Bezdan, Daniela, additional, Bitzer, Michael, additional, Blumert, Conny, additional, Bonifacio, Ezio, additional, Bork, Peer, additional, Boyke, Bunk, additional, Blum, Helmut, additional, Casadei, Nicolas, additional, Clavel, Thomas, additional, Colome-Tatche, Maria, additional, Cornberg, Markus, additional, De La Rosa Velázquez, Inti Alberto, additional, Diefenbach, Andreas, additional, Dilthey, Alexander, additional, Fischer, Nicole, additional, Förstner, Konrad, additional, Franzenburg, Sören, additional, Frick, Julia-Stefanie, additional, Gabernet, Gisela, additional, Gagneur, Julien, additional, Ganzenmueller, Tina, additional, Gauder, Marie, additional, Geißert, Janina, additional, Goesmann, Alexander, additional, Göpel, Siri, additional, Grundhoff, Adam, additional, Grundmann, Hajo, additional, Hain, Torsten, additional, Hanses, Frank, additional, Hehr, Ute, additional, Heimbach, André, additional, Hoeper, Marius, additional, Horn, Friedemann, additional, Hübschmann, Daniel, additional, Hummel, Michael, additional, Iftner, Thomas, additional, Iftner, Angelika, additional, Illig, Thomas, additional, Janssen, Stefan, additional, Kalinowski, Jörn, additional, Kallies, René, additional, Kehr, Birte, additional, Keller, Andreas, additional, Keppler, Oliver T., additional, Kim-Hellmuth, Sarah, additional, Klein, Christoph, additional, Knop, Michael, additional, Kohlbacher, Oliver, additional, Köhrer, Karl, additional, Korbel, Jan, additional, Kremsner, Peter G., additional, Kühnert, Denise, additional, Kurth, Ingo, additional, Landthaler, Markus, additional, Li, Yang, additional, Ludwig, Kerstin U., additional, Makarewicz, Oliwia, additional, Marini, Federico, additional, Marz, Manja, additional, McHardy, Alice C., additional, Mertes, Christian, additional, Münchhoff, Maximilian, additional, Nahnsen, Sven, additional, Nöthen, Markus, additional, Ntoumi, Francine, additional, Nürnberg, Peter, additional, Ossowski, Stephan, additional, Overmann, Jörg, additional, Peter, Silke, additional, Pfeffer, Klaus, additional, Pink, Isabell, additional, Poetsch, Anna R., additional, Protzer, Ulrike, additional, Pühler, Alfred, additional, Rajewsky, Nikolaus, additional, Ralser, Markus, additional, Reiche, Kristin, additional, Rieß, Olaf, additional, Ripke, Stephan, additional, Nunes da Rocha, Ulisses, additional, Rosenstiel, Philip, additional, Saliba, Antoine-Emmanuel, additional, Sander, Leif Erik, additional, Scheithauer, Simone, additional, Schiffer, Philipp, additional, Schmid-Burgk, Jonathan, additional, Schneider, Wulf, additional, Schulte, Eva-Christina, additional, Sczyrba, Alexander, additional, Sharaf, Mariam L., additional, Singh, Yogesh, additional, Sonnabend, Michael, additional, Stegle, Oliver, additional, Stoye, Jens, additional, Theis, Fabian, additional, Ulas, Thomas, additional, Vehreschild, Janne, additional, Velavan, Thirumalaisamy P., additional, Vogel, Jörg, additional, Volland, Sonja, additional, von Kleist, Max, additional, Walker, Andreas, additional, Walter, Jörn, additional, Wieczorek, Dagmar, additional, Winkler, Sylke, additional, and Ziebuhr, John, additional

Published
2021
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35. Autoren

Author

Aguinarte, Lukas J., Ahrens, Marit, Armbrust, Robert, Becker, Sven, Bergmann, Lothar, Bojunga, Jörg, Bug, Gesine, Büntzel, Jens, Burger, Michael, Chromik, Jörg, Chun, Felix K.-H., Dumoulin, Franz Ludwig, Dreyling, Martin, Ebert, Matthias, El-Balat, Ahmed, Ellinger, Jörg, Elsner, Susanne, Enßle, Julius C., Fottner, Christian, Gökbuget, Nicola, Götze, Thorsten Oliver, Halbsguth, Teresa, Hartmann, Sylvia, Höh, Benedikt, Hohenberger, Peter, Hübner, Joachim, Hübner, Jutta, Isfort, Susanne, Kasper, Bernd, Kestler, Angelika, Kleemann, Johannes, Kluth, Luis A., Köhler, Viktoria F., Kollmar, Otto, Lang, Fabian, Makowka, Philipp, Mallmann-Gottschalk, Nina, Mandel, Philipp, Maurer, Gabriele D., Mayer, Arnulf, Meissner, Markus, Menge, Franka, Middeke, Jan Moritz, Miesbach, Wolfgang, Möhler, Markus, Möbus, Volker, Müller, Stefan C., Nauck, Friedemann, Oellerich, Thomas, Özistanbullu, Deniz, Pox, Christian, Richter, Konrad Klaus, Scheich, Sebastian, Schetelig, Johannes, Schnürch, Hans-Georg, Sehouli, Jalid, Seifart, Ulf, Serve, Hubert, Seufferlein, Thomas, Shaid, Shabnam, Soysal, Savas D., Staubitz, Julia I., Steffen, Björn, Steinbach, Joachim P., Stratmann, Jan A., Tsoukakis, Ioannis, Ullrich, Evelyn, Vehreschild, Janne, Metzler, Ivana von, Wolff, Michael von, Voß, Martin, Wagner, Sebastian, Weber, Matthias M., Weber, Sarah, Wege, Henning, Weis, Joachim, Welte, Maria-Noemi, Wenzel, Mike, Wölber, Linn, Wolf, Timo, Zimpel, Carolin, Zurmeyer, David, and Zurmeyer, Sarah

Published
2024
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36. Swarm Learning for decentralized and confidential clinical machine learning

Author

Warnat-Herresthal, Stefanie, Schultze, Hartmut, Ktena, Sofia, Franzenburg, Sören, Frick, Julia-Stefanie, Gabernet, Gisela, Gagneur, Julien, Ganzenmueller, Tina, Gauder, Marie, Geißert, Janina, Goesmann, Alexander, Göpel, Siri, Grundhoff, Adam, Tran, Florian, Grundmann, Hajo, Hain, Torsten, Hanses, Frank, Hehr, Ute, Heimbach, André, Hoeper, Marius, Horn, Friedemann, Hübschmann, Daniel, Hummel, Michael, Iftner, Thomas, Bitzer, Michael, Iftner, Angelika, Illig, Thomas, Janssen, Stefan, Kalinowski, Jörn, Kallies, René, Kehr, Birte, Keppler, Oliver T, Klein, Christoph, Knop, Michael, Kohlbacher, Oliver, Ossowski, Stephan, Köhrer, Karl, Korbel, Jan, Kremsner, Peter G, Kühnert, Denise, Landthaler, Markus, Li, Yang, Ludwig, Kerstin U, Makarewicz, Oliwia, Marz, Manja, McHardy, Alice C, Casadei, Nicolas, Mertes, Christian, Münchhoff, Maximilian, Nahnsen, Sven, Nöthen, Markus M., Ntoumi, Francine, Overmann, Jörg, Peter, Silke, Pfeffer, Klaus, Pink, Isabell, Poetsch, Anna R, Herr, Christian, Protzer, Ulrike, Pühler, Alfred, Rajewsky, Nikolaus, Ralser, Markus, Reiche, Kristin, Ripke, Stephan, da Rocha, Ulisses Nunes, Saliba, Antoine-Emmanuel, Sander, Leif Erik, Sawitzki, Birgit, Petersheim, Daniel, Scheithauer, Simone, Schiffer, Philipp, Schmid-Burgk, Jonathan, Schneider, Wulf, Schulte, Eva-Christina, Sczyrba, Alexander, Sharaf, Mariam L, Singh, Yogesh, Sonnabend, Michael, Stegle, Oliver, Behrends, Uta, Stoye, Jens, Vehreschild, Janne, Velavan, Thirumalaisamy P, Vogel, Jörg, Volland, Sonja, von Kleist, Max, Walker, Andreas, Walter, Jörn, Wieczorek, Dagmar, Winkler, Sylke, Kern, Fabian, Ziebuhr, John, Fehlmann, Tobias, Shastry, Krishnaprasad Lingadahalli, Schommers, Philipp, Lehmann, Clara, Augustin, Max, Rybniker, Jan, Altmüller, Janine, Mishra, Neha, Bernardes, Joana P, Krämer, Benjamin, Bonaguro, Lorenzo, Schulte-Schrepping, Jonas, Manamohan, Sathyanarayanan, De Domenico, Elena, Siever, Christian, Kraut, Michael, Desai, Milind, Monnet, Bruno, Saridaki, Maria, Siegel, Charles Martin, Drews, Anna, Nuesch Germano, Melanie, Theis, Heidi, Mukherjee, Saikat, Heyckendorf, Jan, Schreiber, Stefan, Kim-Hellmuth, Sarah, Study, COVID-19 Aachen, Nattermann, Jacob, Skowasch, Dirk, Kurth, Ingo, Keller, Andreas, Bals, Robert, Nürnberg, Peter, Garg, Vishesh, Rieß, Olaf, Rosenstiel, Philip, Netea, Mihai G, Theis, Fabian, Mukherjee, Sach, Backes, Michael, Aschenbrenner, Anna C, Ulas, Thomas, Initiative, Deutsche COVID-19 Omics, Breteler, Monique, Sarveswara, Ravi, Giamarellos-Bourboulis, Evangelos J, Kox, Matthijs, Becker, Matthias, Cheran, Sorin, Woodacre, Michael S, Goh, Eng Lim, Schultze, Joachim L, Balfanz, Paul, Eggermann, Thomas, Boor, Peter, Händler, Kristian, Hausmann, Ralf, Kuhn, Hannah, Isfort, Susanne, Stingl, Julia Carolin, Schmalzing, Günther, Kuhl, Christiane K, Röhrig, Rainer, Marx, Gernot, Uhlig, Stefan, Dahl, Edgar, Pickkers, Peter, Müller-Wieland, Dirk, Dreher, Michael, Marx, Nikolaus, Angelov, Angel, Bartholomäus, Alexander, Becker, Anke, Bezdan, Daniela, Blumert, Conny, Bonifacio, Ezio, Bork, Peer, Aziz, Ahmad, Boyke, Bunk, Blum, Helmut, Clavel, Thomas, Colome-Tatche, Maria, Cornberg, Markus, De La Rosa Velázquez, Inti Alberto, Diefenbach, Andreas, Dilthey, Alexander, Fischer, Nicole, Förstner, Konrad, and Stem Cell Aging Leukemia and Lymphoma (SALL)

Subjects
Lung Diseases, Male, 0301 basic medicine, Cancer Research, Computer science, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Privacy laws of the United States, Datasets as Topic, computer.software_genre, Disease Outbreaks, 0302 clinical medicine, Software, diagnosis [Leukemia], pathology [Leukemia], Leukocytes, Computational models, Use case, Confidentiality, 030212 general & internal medicine, Precision Medicine, Edge computing, Leukemia, Multidisciplinary, Swarm behaviour, diagnosis [Lung Diseases], ddc, 3. Good health, diagnosis [Tuberculosis], Female, ddc:500, Clinical Decision-Making, Predictive medicine, methods [Clinical Decision-Making], pathology [Leukocytes], Machine learning, Article, 03 medical and health sciences, methods [Precision Medicine], Blockchain, Humans, Tuberculosis, trends [Machine Learning], business.industry, COVID-19, Diagnostic markers, diagnosis [COVID-19], epidemiology [COVID-19], Precision medicine, 030104 developmental biology, Cardiovascular and Metabolic Diseases, Viral infection, Artificial intelligence, business, computer
Abstract

Fast and reliable detection of patients with severe and heterogeneous illnesses is a major goal of precision medicine1,2. Patients with leukaemia can be identified using machine learning on the basis of their blood transcriptomes3. However, there is an increasing divide between what is technically possible and what is allowed, because of privacy legislation4,5. Here, to facilitate the integration of any medical data from any data owner worldwide without violating privacy laws, we introduce Swarm Learning—a decentralized machine-learning approach that unites edge computing, blockchain-based peer-to-peer networking and coordination while maintaining confidentiality without the need for a central coordinator, thereby going beyond federated learning. To illustrate the feasibility of using Swarm Learning to develop disease classifiers using distributed data, we chose four use cases of heterogeneous diseases (COVID-19, tuberculosis, leukaemia and lung pathologies). With more than 16,400 blood transcriptomes derived from 127 clinical studies with non-uniform distributions of cases and controls and substantial study biases, as well as more than 95,000 chest X-ray images, we show that Swarm Learning classifiers outperform those developed at individual sites. In addition, Swarm Learning completely fulfils local confidentiality regulations by design. We believe that this approach will notably accelerate the introduction of precision medicine., Swarm Learning is a decentralized machine learning approach that outperforms classifiers developed at individual sites for COVID-19 and other diseases while preserving confidentiality and privacy.

Published
2021

37. Correction to: All-cause mortality and disease progression in SARS-CoV-2-infected patients with or without antibiotic therapy: an analysis of the LEOSS cohort

Author

Schons, Maximilian J., Caliebe, Amke, Spinner, Christoph D., Classen, Annika Y., Pilgram, Lisa, Ruethrich, Maria M., Rupp, Jan, Nunes de Miranda, Susana M., Römmele, Christoph, Vehreschild, Janne, Jensen, Bjoern-Erik, Vehreschild, Maria, Degenhardt, Christian, Borgmann, Stefan, Hower, Martin, Hanses, Frank, Haselberger, Martina, and Friedrichs, Anette K.

Subjects
Microbiology (medical), Adult, Antimicrobial Stewardship, Infectious Diseases, SARS-CoV-2, Disease Progression, Correction, Humans, General Medicine, Anti-Bacterial Agents, COVID-19 Drug Treatment
Abstract

Reported antibiotic use in coronavirus disease 2019 (COVID-19) is far higher than the actual rate of reported bacterial co- and superinfection. A better understanding of antibiotic therapy in COVID-19 is necessary.6457 SARS-CoV-2-infected cases, documented from March 18, 2020, until February 16, 2021, in the LEOSS cohort were analyzed. As primary endpoint, the correlation between any antibiotic treatment and all-cause mortality/progression to the next more advanced phase of disease was calculated for adult patients in the complicated phase of disease and procalcitonin (PCT) ≤ 0.5 ng/ml. The analysis took the confounders gender, age, and comorbidities into account.Three thousand, six hundred twenty-seven cases matched all inclusion criteria for analyses. For the primary endpoint, antibiotic treatment was not correlated with lower all-cause mortality or progression to the next more advanced (critical) phase (n = 996) (both p 0.05). For the secondary endpoints, patients in the uncomplicated phase (n = 1195), regardless of PCT level, had no lower all-cause mortality and did not progress less to the next more advanced (complicated) phase when treated with antibiotics (p 0.05). Patients in the complicated phase with PCT 0.5 ng/ml and antibiotic treatment (n = 286) had a significantly increased all-cause mortality (p = 0.029) but no significantly different probability of progression to the critical phase (p 0.05).In this cohort, antibiotics in SARS-CoV-2-infected patients were not associated with positive effects on all-cause mortality or disease progression. Additional studies are needed. Advice of local antibiotic stewardship- (ABS-) teams and local educational campaigns should be sought to improve rational antibiotic use in COVID-19 patients.

Published
2021

38. Harmonized procedure coding system for surgical procedures of five European countries (Preprint)

Author

Mellinghoff, Sibylle, primary, Bruns, Carolin, additional, Al-Monajjed, Rouvier, additional, Cornely, Florian, additional, Grosheva, Maria, additional, Hampl, Juergen, additional, Jakob, Carolin, additional, Koehler, Felix, additional, Lechmann, Max, additional, Maged, Bijan, additional, Otto-Lambertz, Christina, additional, Rongisch, Robert, additional, Rutz, Jule, additional, Salmanton-Garcia, Jon, additional, Schlachtenberger, Georg, additional, Stemler, Jannik, additional, Vehreschild, Janne, additional, Wuelfing, Sophia, additional, Cornely, Oliver, additional, and Liss, Blasius, additional

Published
2021
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39. Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients

Author

Aschenbrenner, Anna C, Mouktaroudi, Maria, Saridaki, Maria, McHardy, Alice, Mertes, Christian, Nöthen, Markus, Nürnberg, Peter, Ohler, Uwe, Ossowski, Stephan, Overmann, Jörg, Pfeffer, Klaus, Poetsch, Anna R, Pühler, Alfred, Knoll, Rainer, Rajewsky, Nikolaus, Ralser, Markus, Rieß, Olaf, Ripke, Stephan, Nunes da Rocha, Ulisses, Rosenstiel, Philip, Saliba, Antoine-Emmanuel, Sander, Leif Erik, Sawitzki, Birgit, Schiffer, Philipp, Pecht, Tal, Schneider, Wulf, Schulte, Eva-Christina, Schultze, Joachim L, Sczyrba, Alexander, Singh, Yogesh, Sonnabend, Michael, Stegle, Oliver, Stoye, Jens, Theis, Fabian, Vehreschild, Janne, Kapellos, Theodore S, Vogel, Jörg, von Kleist, Max, Walker, Andreas, Walter, Jörn, Wieczorek, Dagmar, Winkler, Sylke, Ziebuhr, John, Doulou, Sarandia, Kröger, Charlotte, Herbert, Miriam, Holsten, Lisa, Horne, Arik, Gemünd, Ioanna D, Krämer, Benjamin, Rovina, Nikoletta, Agrawal, Shobhit, Dahm, Kilian, van Uelft, Martina, Drews, Anna, Lenkeit, Lena, Bruse, Niklas, Gerretsen, Jelle, Gierlich, Jannik, Becker, Matthias, Oestreich, Marie, Händler, Kristian, Kraut, Michael, Theis, Heidi, Mengiste, Simachew, De Domenico, Elena, Schulte-Schrepping, Jonas, Seep, Lea, Raabe, Jan, Hoffmeister, Christoph, ToVinh, Michael, Antonakos, Nikolaos, Keitel, Verena, Rieke, Gereon, Talevi, Valentina, Skowasch, Dirk, Aziz, N. Ahmad, Pickkers, Peter, van de Veerdonk, Frank L, Netea, Mihai G, Kox, Matthijs, Nuesch-Germano, Melanie, Breteler, Monique M B, Nattermann, Jacob, Koutsoukou, Antonia, Giamarellos-Bourboulis, Evangelos J, Ulas, Thomas, Initiative, German COVID-19 Omics, Altmüller, Janine, Angelov, Angel, Bals, Robert, Bartholomäus, Alexander, Gkizeli, Konstantina, Becker, Anke, Bitzer, Michael, Bonifacio, Ezio, Bork, Peer, Casadei, Nicolas, Clavel, Thomas, Colome-Tatche, Maria, Diefenbach, Andreas, Dilthey, Alexander, Fischer, Nicole, Bonaguro, Lorenzo, Förstner, Konrad, Franzenburg, Sören, Frick, Julia-Stefanie, Gabernet, Gisela, Gagneur, Julien, Ganzenmüller, Tina, Göpel, Siri, Goesmann, Alexander, Hain, Torsten, Heimbach, André, Reusch, Nico, Hummel, Michael, Iftner, Angelika, Iftner, Thomas, Janssen, Stefan, Kalinowski, Jörn, Kallies, René, Kehr, Birte, Keller, Andreas, Kim-Hellmuth, Sarah, Klein, Christoph, Baßler, Kevin, Kohlbacher, Oliver, Köhrer, Karl, Korbel, Jan, Kühnert, Denise, Kurth, Ingo, Landthaler, Markus, Li, Yang, Ludwig, Kerstin, Makarewicz, Oliwia, and Marz, Manja

Subjects
Cancer Research, Neutrophils, virology [COVID-19], cytology [Neutrophils], Drug repurposing, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], lcsh:Medicine, chemistry [RNA], Severity of Illness Index, pathology [COVID-19], Transcriptome, 0302 clinical medicine, Genetics (clinical), Whole blood, immunology [Neutrophils], Principal Component Analysis, 0303 health sciences, metabolism [Neutrophils], Up-Regulation, 3. Good health, Co-expression analysis, Phenotype, medicine.anatomical_structure, metabolism [RNA], 030220 oncology & carcinogenesis, Molecular disease phenotypes, Molecular Medicine, Technology Platforms, lcsh:QH426-470, blood [RNA], Down-Regulation, drug therapy [COVID-19], Granulocyte, Antiviral Agents, 03 medical and health sciences, Immune system, All institutes and research themes of the Radboud University Medical Center, Severity of illness, Genetics, medicine, Humans, ddc:610, Molecular Biology, 030304 developmental biology, Sequence Analysis, RNA, business.industry, Research, lcsh:R, Drug Repositioning, Case-control study, Blood transcriptomics, COVID-19, Human genetics, COVID-19 Drug Treatment, therapeutic use [Antiviral Agents], lcsh:Genetics, Respiratory failure, Cardiovascular and Metabolic Diseases, Case-Control Studies, Immunology, RNA, Stratification, business, Granulocytes
Abstract

Background The SARS-CoV-2 pandemic is currently leading to increasing numbers of COVID-19 patients all over the world. Clinical presentations range from asymptomatic, mild respiratory tract infection, to severe cases with acute respiratory distress syndrome, respiratory failure, and death. Reports on a dysregulated immune system in the severe cases call for a better characterization and understanding of the changes in the immune system. Methods In order to dissect COVID-19-driven immune host responses, we performed RNA-seq of whole blood cell transcriptomes and granulocyte preparations from mild and severe COVID-19 patients and analyzed the data using a combination of conventional and data-driven co-expression analysis. Additionally, publicly available data was used to show the distinction from COVID-19 to other diseases. Reverse drug target prediction was used to identify known or novel drug candidates based on finding from data-driven findings. Results Here, we profiled whole blood transcriptomes of 39 COVID-19 patients and 10 control donors enabling a data-driven stratification based on molecular phenotype. Neutrophil activation-associated signatures were prominently enriched in severe patient groups, which was corroborated in whole blood transcriptomes from an independent second cohort of 30 as well as in granulocyte samples from a third cohort of 16 COVID-19 patients (44 samples). Comparison of COVID-19 blood transcriptomes with those of a collection of over 3100 samples derived from 12 different viral infections, inflammatory diseases, and independent control samples revealed highly specific transcriptome signatures for COVID-19. Further, stratified transcriptomes predicted patient subgroup-specific drug candidates targeting the dysregulated systemic immune response of the host. Conclusions Our study provides novel insights in the distinct molecular subgroups or phenotypes that are not simply explained by clinical parameters. We show that whole blood transcriptomes are extremely informative for COVID-19 since they capture granulocytes which are major drivers of disease severity.

Published
2021

42. Cause-specific mortality after diagnosis of cancer among HIV-positive patients: A collaborative analysis of cohort studies

Author

Trickey, Adam, May, Margaret T., Gill, M. John, Grabar, Sophie, Vehreschild, Janne, Wit, Ferdinand W. N. M., Bonnet, Fabrice, Cavassini, Matthias, Abgrall, Sophie, Berenguer, Juan, Wyen, Christoph, Reiss, Peter, Grabmeier-Pfistershammer, Katharina, Guest, Jodie L., Shepherd, Leah, Teira, Ramon, Monforte, Antonella d'Arminio, del Amo, Julia, Justice, Amy, Costagliola, Dominique, Sterne, Jonathan A. C., Trickey, Adam, May, Margaret T., Gill, M. John, Grabar, Sophie, Vehreschild, Janne, Wit, Ferdinand W. N. M., Bonnet, Fabrice, Cavassini, Matthias, Abgrall, Sophie, Berenguer, Juan, Wyen, Christoph, Reiss, Peter, Grabmeier-Pfistershammer, Katharina, Guest, Jodie L., Shepherd, Leah, Teira, Ramon, Monforte, Antonella d'Arminio, del Amo, Julia, Justice, Amy, Costagliola, Dominique, and Sterne, Jonathan A. C.

Abstract

People living with HIV (PLHIV) are more likely than the general population to develop AIDS-defining malignancies (ADMs) and several non-ADMs (NADMs). Information is lacking on survival outcomes and cause-specific mortality after cancer diagnosis among PLHIV. We investigated causes of death within 5 years of cancer diagnosis in PLHIV enrolled in European and North American HIV cohorts starting antiretroviral therapy (ART) 1996-2015, aged >= 16 years, and subsequently diagnosed with cancer. Cancers were grouped: ADMs, viral NADMs and nonviral NADMs. We calculated cause-specific mortality rates (MR) after diagnosis of specific cancers and compared 5-year survival with the UK and France general populations. Among 83,856 PLHIV there were 4,436 cancer diagnoses. Of 603 deaths after ADM diagnosis, 292 (48%) were due to an ADM. There were 467/847 (55%) and 74/189 (39%) deaths that were due to an NADM after nonviral and viral NADM diagnoses, respectively. MR were higher for diagnoses between 1996 and 2005 versus 2006-2015: ADMs 102 (95% CI 92-113) per 1,000 years versus 88 (78-100), viral NADMs 134 (106-169) versus 111 (93-133) and nonviral NADMs 264 (232-300) versus 226 (206-248). Estimated 5-year survival for PLHIV diagnosed with liver (29% [19-39%]), lung (18% [13-23%]) and cervical (75% [63-84%]) cancer was similar to general populations. Survival after Hodgkin's lymphoma diagnosis was lower in PLHIV (75% [67-81%]). Among ART-treated PLHIV diagnosed with cancer, MR and causes of death varied by cancer type, with mortality highest for liver and lung cancers. Deaths within 5 years of NADM diagnoses were more likely to be from cancer than AIDS.

Published
2020

43. Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19

Author

Bernardes, Joana P., primary, Mishra, Neha, additional, Tran, Florian, additional, Bahmer, Thomas, additional, Best, Lena, additional, Blase, Johanna I., additional, Bordoni, Dora, additional, Franzenburg, Jeanette, additional, Geisen, Ulf, additional, Josephs-Spaulding, Jonathan, additional, Köhler, Philipp, additional, Künstner, Axel, additional, Rosati, Elisa, additional, Aschenbrenner, Anna C., additional, Bacher, Petra, additional, Baran, Nathan, additional, Boysen, Teide, additional, Brandt, Burkhard, additional, Bruse, Niklas, additional, Dörr, Jonathan, additional, Dräger, Andreas, additional, Elke, Gunnar, additional, Ellinghaus, David, additional, Fischer, Julia, additional, Forster, Michael, additional, Franke, Andre, additional, Franzenburg, Sören, additional, Frey, Norbert, additional, Friedrichs, Anette, additional, Fuß, Janina, additional, Glück, Andreas, additional, Hamm, Jacob, additional, Hinrichsen, Finn, additional, Hoeppner, Marc P., additional, Imm, Simon, additional, Junker, Ralf, additional, Kaiser, Sina, additional, Kan, Ying H., additional, Knoll, Rainer, additional, Lange, Christoph, additional, Laue, Georg, additional, Lier, Clemens, additional, Lindner, Matthias, additional, Marinos, Georgios, additional, Markewitz, Robert, additional, Nattermann, Jacob, additional, Noth, Rainer, additional, Pickkers, Peter, additional, Rabe, Klaus F., additional, Renz, Alina, additional, Röcken, Christoph, additional, Rupp, Jan, additional, Schaffarzyk, Annika, additional, Scheffold, Alexander, additional, Schulte-Schrepping, Jonas, additional, Schunk, Domagoj, additional, Skowasch, Dirk, additional, Ulas, Thomas, additional, Wandinger, Klaus-Peter, additional, Wittig, Michael, additional, Zimmermann, Johannes, additional, Busch, Hauke, additional, Hoyer, Bimba F., additional, Kaleta, Christoph, additional, Heyckendorf, Jan, additional, Kox, Matthijs, additional, Rybniker, Jan, additional, Schreiber, Stefan, additional, Schultze, Joachim L., additional, Rosenstiel, Philip, additional, Banovich, Nicholas E., additional, Desai, Tushar, additional, Eickelberg, Oliver, additional, Haniffa, Muzlifa, additional, Horvath, Peter, additional, Kropski, Jonathan A., additional, Lafyatis, Robert, additional, Lundeberg, Joakim, additional, Meyer, Kerstin, additional, Nawijn, Martijn C., additional, Nikolic, Marko, additional, Ordovas Montanes, Jose, additional, Pe’er, Dana, additional, Tata, Purushothama Rao, additional, Rawlins, Emma, additional, Regev, Aviv, additional, Reyfman, Paul, additional, Samakovlis, Christos, additional, Schultze, Joachim, additional, Shalek, Alex, additional, Shepherd, Douglas, additional, Spence, Jason, additional, Teichmann, Sarah, additional, Theis, Fabian, additional, Tsankov, Alexander, additional, van den Berge, Maarten, additional, von Papen, Michael, additional, Whitsett, Jeffrey, additional, Zaragosi, Laure Emmanuelle, additional, Angelov, Angel, additional, Bals, Robert, additional, Bartholomäus, Alexander, additional, Becker, Anke, additional, Bezdan, Daniela, additional, Bonifacio, Ezio, additional, Bork, Peer, additional, Clavel, Thomas, additional, Colme-Tatche, Maria, additional, Diefenbach, Andreas, additional, Dilthey, Alexander, additional, Fischer, Nicole, additional, Förstner, Konrad, additional, Frick, Julia-Stefanie, additional, Gagneur, Julien, additional, Goesmann, Alexander, additional, Hain, Torsten, additional, Hummel, Michael, additional, Janssen, Stefan, additional, Kalinowski, Jörn, additional, Kallies, René, additional, Kehr, Birte, additional, Keller, Andreas, additional, Kim-Hellmuth, Sarah, additional, Klein, Christoph, additional, Kohlbacher, Oliver, additional, Korbel, Jan O., additional, Kurth, Ingo, additional, Landthaler, Markus, additional, Li, Yang, additional, Ludwig, Kerstin, additional, Makarewicz, Oliwia, additional, Marz, Manja, additional, McHardy, Alice, additional, Mertes, Christian, additional, Nöthen, Markus, additional, Nürnberg, Peter, additional, Ohler, Uwe, additional, Ossowski, Stephan, additional, Overmann, Jörg, additional, Peter, Silke, additional, Pfeffer, Klaus, additional, Poetsch, Anna R., additional, Pühler, Alfred, additional, Rajewsky, Niklaus, additional, Ralser, Markus, additional, Rieß, Olaf, additional, Ripke, Stephan, additional, Nunes da Rocha, Ulisses, additional, Saliba, Antoine-Emmanuel, additional, Sander, Leif Erik, additional, Sawitzki, Birgit, additional, Schiffer, Philipp, additional, Schulte, Eva-Christina, additional, Sczyrba, Alexander, additional, Stegle, Oliver, additional, Stoye, Jens, additional, Vehreschild, Janne, additional, Vogel, Jörg, additional, von Kleist, Max, additional, Walker, Andreas, additional, Walter, Jörn, additional, Wieczorek, Dagmar, additional, and Ziebuhr, John, additional

Published
2020
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46. Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment

Author

Schulte-Schrepping, Jonas, primary, Reusch, Nico, additional, Paclik, Daniela, additional, Baßler, Kevin, additional, Schlickeiser, Stephan, additional, Zhang, Bowen, additional, Krämer, Benjamin, additional, Krammer, Tobias, additional, Brumhard, Sophia, additional, Bonaguro, Lorenzo, additional, De Domenico, Elena, additional, Wendisch, Daniel, additional, Grasshoff, Martin, additional, Kapellos, Theodore S., additional, Beckstette, Michael, additional, Pecht, Tal, additional, Saglam, Adem, additional, Dietrich, Oliver, additional, Mei, Henrik E., additional, Schulz, Axel R., additional, Conrad, Claudia, additional, Kunkel, Désirée, additional, Vafadarnejad, Ehsan, additional, Xu, Cheng-Jian, additional, Horne, Arik, additional, Herbert, Miriam, additional, Drews, Anna, additional, Thibeault, Charlotte, additional, Pfeiffer, Moritz, additional, Hippenstiel, Stefan, additional, Hocke, Andreas, additional, Müller-Redetzky, Holger, additional, Heim, Katrin-Moira, additional, Machleidt, Felix, additional, Uhrig, Alexander, additional, Bosquillon de Jarcy, Laure, additional, Jürgens, Linda, additional, Stegemann, Miriam, additional, Glösenkamp, Christoph R., additional, Volk, Hans-Dieter, additional, Goffinet, Christine, additional, Landthaler, Markus, additional, Wyler, Emanuel, additional, Georg, Philipp, additional, Schneider, Maria, additional, Dang-Heine, Chantip, additional, Neuwinger, Nick, additional, Kappert, Kai, additional, Tauber, Rudolf, additional, Corman, Victor, additional, Raabe, Jan, additional, Kaiser, Kim Melanie, additional, Vinh, Michael To, additional, Rieke, Gereon, additional, Meisel, Christian, additional, Ulas, Thomas, additional, Becker, Matthias, additional, Geffers, Robert, additional, Witzenrath, Martin, additional, Drosten, Christian, additional, Suttorp, Norbert, additional, von Kalle, Christof, additional, Kurth, Florian, additional, Händler, Kristian, additional, Schultze, Joachim L., additional, Aschenbrenner, Anna C., additional, Li, Yang, additional, Nattermann, Jacob, additional, Sawitzki, Birgit, additional, Saliba, Antoine-Emmanuel, additional, Sander, Leif Erik, additional, Angelov, Angel, additional, Bals, Robert, additional, Bartholomäus, Alexander, additional, Becker, Anke, additional, Bezdan, Daniela, additional, Bonifacio, Ezio, additional, Bork, Peer, additional, Clavel, Thomas, additional, Colome-Tatche, Maria, additional, Diefenbach, Andreas, additional, Dilthey, Alexander, additional, Fischer, Nicole, additional, Förstner, Konrad, additional, Frick, Julia-Stefanie, additional, Gagneur, Julien, additional, Goesmann, Alexander, additional, Hain, Torsten, additional, Hummel, Michael, additional, Janssen, Stefan, additional, Kalinowski, Jörn, additional, Kallies, René, additional, Kehr, Birte, additional, Keller, Andreas, additional, Kim-Hellmuth, Sarah, additional, Klein, Christoph, additional, Kohlbacher, Oliver, additional, Korbel, Jan O., additional, Kurth, Ingo, additional, Ludwig, Kerstin, additional, Makarewicz, Oliwia, additional, Marz, Manja, additional, McHardy, Alice, additional, Mertes, Christian, additional, Nöthen, Markus, additional, Nürnberg, Peter, additional, Ohler, Uwe, additional, Ossowski, Stephan, additional, Overmann, Jörg, additional, Peter, Silke, additional, Pfeffer, Klaus, additional, Poetsch, Anna R., additional, Pühler, Alfred, additional, Rajewsky, Nikolaus, additional, Ralser, Markus, additional, Rieß, Olaf, additional, Ripke, Stephan, additional, Nunes da Rocha, Ulisses, additional, Rosenstiel, Philip, additional, Schiffer, Philipp, additional, Schulte, Eva-Christina, additional, Sczyrba, Alexander, additional, Stegle, Oliver, additional, Stoye, Jens, additional, Theis, Fabian, additional, Vehreschild, Janne, additional, Vogel, Jörg, additional, von Kleist, Max, additional, Walker, Andreas, additional, Walter, Jörn, additional, Wieczorek, Dagmar, additional, and Ziebuhr, John, additional

Published
2020
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47. Cause‐specific mortality after diagnosis of cancer among HIV‐positive patients: A collaborative analysis of cohort studies

Author

Trickey, Adam, primary, May, Margaret T., additional, Gill, M. John, additional, Grabar, Sophie, additional, Vehreschild, Janne, additional, Wit, Ferdinand W.N.M., additional, Bonnet, Fabrice, additional, Cavassini, Matthias, additional, Abgrall, Sophie, additional, Berenguer, Juan, additional, Wyen, Christoph, additional, Reiss, Peter, additional, Grabmeier‐Pfistershammer, Katharina, additional, Guest, Jodie L., additional, Shepherd, Leah, additional, Teira, Ramon, additional, d'Arminio Monforte, Antonella, additional, Amo, Julia, additional, Justice, Amy, additional, Costagliola, Dominique, additional, and Sterne, Jonathan A.C., additional

Published
2020
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49. 412. Clinical and Pharmacoeconomic Evaluation of Antifungal Prophylaxis With Continuous Micafungin Compared to Posaconazole With Micafungin Bridging in Patients Undergoing Allogeneic Stem Cell Transplantation: A 6-Year Cohort Analysis

Author

Heimann, Sebastian M, primary, Vehreschild, Maria J G T, additional, Franke, Bernd, additional, Cornely, Oliver, additional, Hamprecht, Axel, additional, Piepenbrock, Ellen, additional, Scheid, Christoph, additional, and Vehreschild, Janne, additional

Published
2018
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