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1. Role and benefits of infectious diseases specialists in the COVID-19 pandemic: Multilevel analysis of care provision in German hospitals using data from the Lean European Open Survey on SARS-CoV-2 infected patients (LEOSS) cohort

Author

Tscharntke, Lene T., Jung, Norma, Hanses, Frank, Koll, Carolin E. M., Pilgram, Lisa, Rieg, Siegbert, Borgmann, Stefan, de Miranda, Susana M. Nunes, Scherer, Margarete, Spinner, Christoph D., Rüthrich, Maria, Vehreschild, Maria J. G. T., von Bergwelt-Baildon, Michael, Wille, Kai, Merle, Uta, Hower, Martin, Rothfuss, Katja, Nadalin, Silvio, Klinker, Hartwig, Fürst, Julia, Greiffendorf, Ingo, Raichle, Claudia, Friedrichs, Anette, Rauschning, Dominic, de With, Katja, Eberwein, Lukas, Riedel, Christian, Milovanovic, Milena, Worm, Maximilian, Schultheis, Beate, Schubert, Jörg, Bota, Marc, Beutel, Gernot, Glück, Thomas, Schmid, Michael, Wintermantel, Tobias, Peetz, Helga, Steiner, Stephan, Ribel, Elena, Schäfer, Harald, Vehreschild, Jörg Janne, and Stecher, Melanie

Published
2024
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2. Incidence and risk factors for HIV-tuberculosis coinfection in the Cologne–Bonn region: a retrospective cohort study

Author

Suárez, Isabelle, Rauschning, Dominic, Schüller, Cora, Hagemeier, Anna, Stecher, Melanie, Lehmann, Clara, Schommers, Philipp, Schlabe, Stefan, Vehreschild, Jörg-Janne, Koll, Carolin, Schwarze-Zander, Carolynne, Wasmuth, Jan-Christian, Klingmüller, Angela, Rockstroh, Jürgen Kurt, Fätkenheuer, Gerd, Boesecke, Christoph, and Rybniker, Jan

Published
2024
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3. Definition of the Post-COVID syndrome using a symptom-based Post-COVID score in a prospective, multi-center, cross-sectoral cohort of the German National Pandemic Cohort Network (NAPKON)

Author

Appel, Katharina S., Nürnberger, Carolin, Bahmer, Thomas, Förster, Christian, Polidori, Maria Cristina, Kohls, Mirjam, Kraus, Tanja, Hettich-Damm, Nora, Petersen, Julia, Blaschke, Sabine, Bröhl, Isabel, Butzmann, Jana, Dashti, Hiwa, Deckert, Jürgen, Dreher, Michael, Fiedler, Karin, Finke, Carsten, Geisler, Ramsia, Hanses, Frank, Hopff, Sina M., Jensen, Björn-Erik O., Konik, Margarethe, Lehnert, Kristin, de Miranda, Susana M. Nunes, Mitrov, Lazar, Miljukov, Olga, Reese, Jens-Peter, Rohde, Gernot, Scherer, Margarete, Tausche, Kristin, Tebbe, Johannes J., Vehreschild, Jörg Janne, Voit, Florian, Wagner, Patricia, Weigl, Martin, and Lemhöfer, Christina

Published
2024
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4. A precise performance-based reimbursement model for the multi-centre NAPKON cohorts – development and evaluation

Author

Appel, Katharina S., Lee, Chin Huang, Nunes de Miranda, Susana M., Maier, Daniel, Reese, Jens-Peter, Anton, Gabriele, Bahmer, Thomas, Ballhausen, Sabrina, Balzuweit, Beate, Bellinghausen, Carla, Blumentritt, Arne, Brechtel, Markus, Chaplinskaya-Sobol, Irina, Erber, Johanna, Fiedler, Karin, Geisler, Ramsia, Heyder, Ralf, Illig, Thomas, Kohls, Mirjam, Kollek, Jenny, Krist, Lilian, Lorbeer, Roberto, Miljukov, Olga, Mitrov, Lazar, Nürnberger, Carolin, Pape, Christian, Pley, Christina, Schäfer, Christian, Schaller, Jens, Schattschneider, Mario, Scherer, Margarete, Schulze, Nick, Stahl, Dana, Stubbe, Hans Christian, Tamminga, Thalea, Tebbe, Johannes Josef, Vehreschild, Maria J. G. T., Wiedmann, Silke, and Vehreschild, Jörg Janne

Published
2024
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5. Development of a long noncoding RNA-based machine learning model to predict COVID-19 in-hospital mortality

Author

Devaux, Yvan, Zhang, Lu, Lumley, Andrew I., Karaduzovic-Hadziabdic, Kanita, Mooser, Vincent, Rousseau, Simon, Shoaib, Muhammad, Satagopam, Venkata, Adilovic, Muhamed, Srivastava, Prashant Kumar, Emanueli, Costanza, Martelli, Fabio, Greco, Simona, Badimon, Lina, Padro, Teresa, Lustrek, Mitja, Scholz, Markus, Rosolowski, Maciej, Jordan, Marko, Brandenburger, Timo, Benczik, Bettina, Agg, Bence, Ferdinandy, Peter, Vehreschild, Jörg Janne, Lorenz-Depiereux, Bettina, Dörr, Marcus, Witzke, Oliver, Sanchez, Gabriel, Kul, Seval, Baker, Andy H., Fagherazzi, Guy, Ollert, Markus, Wereski, Ryan, Mills, Nicholas L., and Firat, Hüseyin

Published
2024
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8. Persistent symptoms and risk factors predicting prolonged time to symptom-free after SARS‑CoV‑2 infection: an analysis of the baseline examination of the German COVIDOM/NAPKON-POP cohort

Author

Shi, Yanyan, Strobl, Ralf, Apfelbacher, Christian, Bahmer, Thomas, Geisler, Ramsia, Heuschmann, Peter, Horn, Anna, Hoven, Hanno, Keil, Thomas, Krawczak, Michael, Krist, Lilian, Lemhöfer, Christina, Lieb, Wolfgang, Lorenz-Depiereux, Bettina, Mikolajczyk, Rafael, Montellano, Felipe A., Reese, Jens Peter, Schreiber, Stefan, Skoetz, Nicole, Störk, Stefan, Vehreschild, Jörg Janne, Witzenrath, Martin, and Grill, Eva

Published
2023
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9. Depression and fatigue six months post-COVID-19 disease are associated with overlapping symptom constellations: A prospective, multi-center, population-based cohort study

Author

Weiß, Martin, Gutzeit, Julian, Appel, Katharina S., Bahmer, Thomas, Beutel, Manfred, Deckert, Jürgen, Fricke, Julia, Hanß, Sabine, Hettich-Damm, Nora, Heuschmann, Peter U., Horn, Anna, Jauch-Chara, Kamila, Kohls, Mirjam, Krist, Lilian, Lorenz-Depiereux, Bettina, Otte, Christian, Pape, Daniel, Reese, Jens-Peter, Schreiber, Stefan, Störk, Stefan, Vehreschild, Jörg Janne, and Hein, Grit

Published
2024
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10. Profile of the multicenter cohort of the German Cancer Consortium’s Clinical Communication Platform

Author

Maier, Daniel, Vehreschild, Jörg Janne, Uhl, Barbara, Meyer, Sandra, Berger-Thürmel, Karin, Boerries, Melanie, Braren, Rickmer, Grünwald, Viktor, Hadaschik, Boris, Palm, Stefan, Singer, Susanne, Stuschke, Martin, Juárez, David, Delpy, Pierre, Lambarki, Mohamed, Hummel, Michael, Engels, Cäcilia, Andreas, Stefanie, Gökbuget, Nicola, Ihrig, Kristina, Burock, Susen, Keune, Dietmar, Eggert, Angelika, Keilholz, Ulrich, Schulz, Hagen, Büttner, Daniel, Löck, Steffen, Krause, Mechthild, Esins, Mirko, Ressing, Frank, Schuler, Martin, Brandts, Christian, Brucker, Daniel P., Husmann, Gabriele, Oellerich, Thomas, Metzger, Patrick, Voigt, Frederik, Illert, Anna L., Theobald, Matthias, Kindler, Thomas, Sudhof, Ursula, Reckmann, Achim, Schwinghammer, Felix, Nasseh, Daniel, Weichert, Wilko, von Bergwelt-Baildon, Michael, Bitzer, Michael, Malek, Nisar, Öner, Öznur, Schulze-Osthoff, Klaus, Bartels, Stefan, Haier, Jörg, Ammann, Raimund, Schmidt, Anja Franziska, Guenther, Bernd, Janning, Melanie, Kasper, Bernd, Loges, Sonja, Stilgenbauer, Stephan, Kuhn, Peter, Tausch, Eugen, Runow, Silvana, Kerscher, Alexander, Neumann, Michael, Breu, Martin, Lablans, Martin, and Serve, Hubert

Published
2023
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11. Drug Resistance Spread in 6 Metropolitan Regions, Germany, 2001-20181.

Author

Stecher, Melanie, Chaillon, Antoine, Stephan, Christoph, Knops, Elena, Kohmer, Niko, Lehmann, Clara, Eberle, Josef, Bogner, Johannes, Spinner, Christoph D, Eis-Hübinger, Anna Maria, Wasmuth, Jan-Christian, Schäfer, Guido, Behrens, Georg, Mehta, Sanjay R, Vehreschild, Jörg Janne, and Hoenigl, Martin

Subjects
ART, Germany, HIV transmission, antimicrobial resistance, antiretroviral therapy, mutations, phylogenetic analysis, public health, Microbiology, Clinical Sciences, Medical Microbiology, Public Health and Health Services
Abstract

We analyzed 1,397 HIV-1 pol sequences of antiretroviral therapy-naive patients in a total of 7 university hospitals in Bonn, Cologne, Frankfurt, Hamburg, Hannover, and Munich, Germany. Phylogenetic and network analysis elucidated numerous cases of shared drug resistance mutations among genetically linked patients; K103N was the most frequently shared mutation.

Published
2020

12. Frequently asked questions regarding SARS-CoV-2 in cancer patients-recommendations for clinicians caring for patients with malignant diseases.

Author

von Lilienfeld-Toal, Marie, Vehreschild, Jörg Janne, Cornely, Oliver, Pagano, Livio, Compagno, Francesca, EHA Infectious Disease Scientific Working Group, and Hirsch, Hans H

Subjects
EHA Infectious Disease Scientific Working Group, Humans, Pneumonia, Viral, Coronavirus Infections, Neoplasms, Patient Care, Infection Control, Practice Guidelines as Topic, Infectious Disease Transmission, Patient-to-Professional, Pandemics, Betacoronavirus, COVID-19, SARS-CoV-2, Rare Diseases, Cancer, Clinical Research, Infectious Diseases, Patient Safety, Vaccine Related, Prevention, Hematology, Biodefense, Lung, Emerging Infectious Diseases, Infection, Good Health and Well Being, Clinical Sciences, Oncology and Carcinogenesis, Immunology
Abstract

Since early 2020, the SARS-CoV-2 pandemic has a massive impact on health care systems worldwide. Patients with malignant diseases are assumed to be at increased risk for a worse outcome of SARS-CoV-2 infection, and therefore, guidance regarding prevention and management of the infection as well as safe administration of cancer-therapy is required. Here, we provide recommendations for the management of patients with malignant disease in the times of COVID-19. These recommendations were prepared by an international panel of experts and then consented by the EHA Scientific Working Group on Infection in Hematology. The primary aim is to enable clinicians to provide optimal cancer care as safely as possible, since the most important protection for patients with malignant disease is the best-possible control of the underlying disease.

Published
2020

13. The German National Pandemic Cohort Network (NAPKON): rationale, study design and baseline characteristics

Author

Schons, Maximilian, Pilgram, Lisa, Reese, Jens-Peter, Stecher, Melanie, Anton, Gabriele, Appel, Katharina S., Bahmer, Thomas, Bartschke, Alexander, Bellinghausen, Carla, Bernemann, Inga, Brechtel, Markus, Brinkmann, Folke, Brünn, Clara, Dhillon, Christine, Fiessler, Cornelia, Geisler, Ramsia, Hamelmann, Eckard, Hansch, Stefan, Hanses, Frank, Hanß, Sabine, Herold, Susanne, Heyder, Ralf, Hofmann, Anna-Lena, Hopff, Sina Marie, Horn, Anna, Jakob, Carolin, Jiru-Hillmann, Steffi, Keil, Thomas, Khodamoradi, Yascha, Kohls, Mirjam, Kraus, Monika, Krefting, Dagmar, Kunze, Sonja, Kurth, Florian, Lieb, Wolfgang, Lippert, Lena Johanna, Lorbeer, Roberto, Lorenz-Depiereux, Bettina, Maetzler, Corina, Miljukov, Olga, Nauck, Matthias, Pape, Daniel, Püntmann, Valentina, Reinke, Lennart, Römmele, Christoph, Rudolph, Stefanie, Sass, Julian, Schäfer, Christian, Schaller, Jens, Schattschneider, Mario, Scheer, Christian, Scherer, Margarete, Schmidt, Sein, Schmidt, Julia, Seibel, Kristina, Stahl, Dana, Steinbeis, Fridolin, Störk, Stefan, Tauchert, Maike, Tebbe, Johannes Josef, Thibeault, Charlotte, Toepfner, Nicole, Ungethüm, Kathrin, Vadasz, Istvan, Valentin, Heike, Wiedmann, Silke, Zoller, Thomas, Nagel, Eike, Krawczak, Michael, von Kalle, Christof, Illig, Thomas, Schreiber, Stefan, Witzenrath, Martin, Heuschmann, Peter, and Vehreschild, Jörg Janne

Published
2022
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14. The DKTK EXLIQUID consortium – exploiting liquid biopsies to advance cancer precision medicine for molecular tumor board patients

Author

Mack Matthias, Broche Julian, George Stephen, Hajjari Zahra, Janke Florian, Ranganathan Lavanya, Ashouri Mohammadreza, Bleul Sabine, Desuki Alexander, Engels Cecilia, Fliedner Stephanie M.J., Hartmann Nils, Hummel Michael, Janning Melanie, Kiel Alexander, Köhler Thomas, Koschade Sebastian, Lablans Martin, Lambarki Mohamed, Loges Sonja, Lueong Smiths, Meyer Sandra, Ossowski Stephan, Scherer Florian, Schroeder Christopher, Skowronek Patrick, Thiede Christian, Uhl Barbara, Vehreschild Jörg Janne, von Bubnoff Nikolas, Wagner Sebastian, Werner Tamara V., Westphalen C. Benedikt, Fresser Patrizia, Sültmann Holger, Tinhofer Ingeborg, and Winter Christof

Subjects
liquid profiling, molecular profiling, precision oncology, Medical technology, R855-855.5
Abstract

Testing for genetic alterations in tumor tissue allows clinicians to identify patients who most likely will benefit from molecular targeted treatment. EXLIQUID – exploiting liquid biopsies to advance cancer precision medicine – investigates the potential of additional non-invasive tools for guiding therapy decisions and monitoring of advanced cancer patients. The term “liquid biopsy” (LB) refers to non-invasive analysis of tumor-derived circulating material such as cell-free DNA in blood samples from cancer patients. Although recent technological advances allow sensitive and specific detection of LB biomarkers, only few LB assays have entered clinical routine to date. EXLIQUID is a German Cancer Consortium (DKTK)-wide joint funding project that aims at establishing LBs as a minimally-invasive tool to analyze molecular changes in circulating tumor DNA (ctDNA). Here, we present the structure, clinical aim, and methodical approach of the new DKTK EXLIQUID consortium. Within EXLIQUID, we will set up a multicenter repository of high-quality LB samples from patients participating in DKTK MASTER and local molecular tumor boards, which use molecular profiles of tumor tissues to guide targeted therapies. We will develop LB assays for monitoring of therapy efficacy by the analysis of tumor mutant variants and tumor-specific DNA methylation patterns in ctDNA from these patients. By bringing together LB experts from all DKTK partner sites and exploiting the diversity of their particular expertise, complementary skills and technologies, the EXLIQUID consortium addresses the challenges of translating LBs into the clinic. The DKTK structure provides EXLIQUID a unique position for the identification of liquid biomarkers even in less common tumor types, thereby extending the group of patients benefitting from non-invasive LB testing. Besides its scientific aims, EXLIQUID is building a valuable precision oncology cohort and LB platform which will be available for future collaborative research studies within the DKTK and beyond.

Published
2022
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15. Chronic liver enzyme elevation and use of contemporary ARVs among persons living with HIV

Author

Roen, Ashley O, primary, Peters, Lars, additional, Wandeler, Gilles, additional, van der Valk, Marc, additional, Zangerle, Robert, additional, Günthard, Huldrych F, additional, Wit, Ferdinand, additional, Mussini, Cristina, additional, De Wit, Stéphane, additional, d’Arminio Monforte, Antonella, additional, Vehreschild, Jörg Janne, additional, Castagna, Antonella, additional, Jaschinski, Nadine, additional, Vannappagari, Vani, additional, Chen, Linda, additional, Tallada, Joan, additional, C’mar, John, additional, Mocroft, Amanda, additional, and Ryom, Lene, additional

Published
2024
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16. Prediction of COVID-19 deterioration in high-risk patients at diagnosis: an early warning score for advanced COVID-19 developed by machine learning

Author

Jakob, Carolin E. M., Mahajan, Ujjwal Mukund, Oswald, Marcus, Stecher, Melanie, Schons, Maximilian, Mayerle, Julia, Rieg, Siegbert, Pletz, Mathias, Merle, Uta, Wille, Kai, Borgmann, Stefan, Spinner, Christoph D., Dolff, Sebastian, Scherer, Clemens, Pilgram, Lisa, Rüthrich, Maria, Hanses, Frank, Hower, Martin, Strauß, Richard, Massberg, Steffen, Er, Ahmet Görkem, Jung, Norma, Vehreschild, Jörg Janne, Stubbe, Hans, Tometten, Lukas, and König, Rainer

Published
2022
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18. Hotspots of Transmission Driving the Local Human Immunodeficiency Virus Epidemic in the Cologne-Bonn Region, Germany

Author

Stecher, Melanie, Hoenigl, Martin, Eis-Hübinger, Anna Maria, Lehmann, Clara, Fätkenheuer, Gerd, Wasmuth, Jan-Christian, Knops, Elena, Vehreschild, Jörg Janne, Mehta, Sanjay, and Chaillon, Antoine

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, HIV/AIDS, Infectious Diseases, Infection, Good Health and Well Being, Adult, Epidemics, Female, Gene Flow, Genes, pol, Genetic Linkage, Germany, HIV Infections, HIV-1, Hospitals, University, Humans, Male, Middle Aged, Multigene Family, Phylogeography, Public Health, Retrospective Studies, Sequence Analysis, RNA, Spatio-Temporal Analysis, Travel, HIV transmission, geospatial dispersial, phylogeographic analyses, public health, Biological Sciences, Medical and Health Sciences, Microbiology, Clinical sciences
Abstract

BackgroundGeographical allocation of interventions focusing on hotspots of human immunodeficiency virus (HIV) transmission has the potential to improve efficiency. We used phylogeographic analyses to identify hotspots of the HIV transmission in Cologne-Bonn, Germany.MethodsWe included 714 HIV-1 infected individuals, followed up at the University Hospitals Cologne and Bonn. Distance-based molecular network analyses were performed to infer putative relationships. Characteristics of genetically linked individuals and assortativity (shared characteristics) were analyzed. Geospatial diffusion (ie, viral gene flow) was evaluated using a Slatkin-Maddison approach. Geospatial dispersal was determined by calculating the average distance between the residences of linked individuals (centroids of 3-digit zip code).ResultsIn sum, 217/714 (30.4%) sequences had a putative genetic linkage, forming 77 clusters (size range: 2-8). Linked individuals were more likely to live in areas surrounding the city center (P = .043),

Published
2019

19. Severity, predictors and clinical correlates of Post-COVID syndrome (PCS) in Germany: A prospective, multi-centre, population-based cohort study

Author

Bahmer, Thomas, Borzikowsky, Christoph, Lieb, Wolfgang, Horn, Anna, Krist, Lilian, Fricke, Julia, Scheibenbogen, Carmen, Rabe, Klaus F., Maetzler, Walter, Maetzler, Corina, Laudien, Martin, Frank, Derk, Ballhausen, Sabrina, Hermes, Anne, Miljukov, Olga, Haeusler, Karl Georg, Mokhtari, Nour Eddine El, Witzenrath, Martin, Vehreschild, Jörg Janne, Krefting, Dagmar, Pape, Daniel, Montellano, Felipe A., Kohls, Mirjam, Morbach, Caroline, Störk, Stefan, Reese, Jens-Peter, Keil, Thomas, Heuschmann, Peter, Krawczak, Michael, and Schreiber, Stefan

Published
2022
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20. Development and validation of BLOOMY prediction scores for 14-day and 6-month mortality in hospitalised adults with bloodstream infections: a multicentre, prospective, cohort study

Author

Lemke, Elke, Thoma, Norbert, Wolke, Solvy, Imirzalioglu, Can, Herold, Susanne, Tewes, Nicole, Fritzenwanker, Moritz, Vehreschild, Jörg Janne, Classen, Annika Yanina, Tobys, David, Higgins, Paul, Blum, Yannic, Kleipaß, Matthias, Höltig, Lisa, Nagel, Katharina, Schmauder, Kristina, Künstle, Larissa, Stoll, Elisabeth, Dinkelacker, Ariane Gertraud, Peyerl-Hoffmann, Gabriele, Häcker, Georg, Spitznagel, Heike, Olawumi-Hurter, Sara Christina, Tacconelli, Evelina, Göpel, Siri, Gladstone, Beryl P, Eisenbeis, Simone, Hölzl, Florian, Buhl, Michael, Górska, Anna, Cattaneo, Chiara, Mischnik, Alexander, Rieg, Siegbert, Rohde, Anna M, Kohlmorgen, Britta, Falgenhauer, Jane, Trauth, Janina, Käding, Nadja, Kramme, Evelyn, Biehl, Lena M, Walker, Sarah V, Peter, Silke, Gastmeier, Petra, Chakraborty, Trinad, Vehreschild, Maria JGT, Seifert, Harald, Rupp, Jan, and Kern, Winfried V

Published
2022
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21. Statistical biases due to anonymization evaluated in an open clinical dataset from COVID-19 patients

Author

Koll, Carolin E. M., Hopff, Sina M., Meurers, Thierry, Lee, Chin Huang, Kohls, Mirjam, Stellbrink, Christoph, Thibeault, Charlotte, Reinke, Lennart, Steinbrecher, Sarah, Schreiber, Stefan, Mitrov, Lazar, Frank, Sandra, Miljukov, Olga, Erber, Johanna, Hellmuth, Johannes C., Reese, Jens-Peter, Steinbeis, Fridolin, Bahmer, Thomas, Hagen, Marina, Meybohm, Patrick, Hansch, Stefan, Vadász, István, Krist, Lilian, Jiru-Hillmann, Steffi, Prasser, Fabian, and Vehreschild, Jörg Janne

Published
2022
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22. Machine Learning Based Prediction of COVID-19 Mortality Suggests Repositioning of Anticancer Drug for Treating Severe Cases

Author

Linden, Thomas, Hanses, Frank, Domingo-Fernández, Daniel, DeLong, Lauren Nicole, Kodamullil, Alpha Tom, Schneider, Jochen, Vehreschild, Maria J.G.T., Lanznaster, Julia, Ruethrich, Maria Madeleine, Borgmann, Stefan, Hower, Martin, Wille, Kai, Feldt, Torsten, Rieg, Siegbert, Hertenstein, Bernd, Wyen, Christoph, Roemmele, Christoph, Vehreschild, Jörg Janne, Jakob, Carolin E.M., Stecher, Melanie, Kuzikov, Maria, Zaliani, Andrea, and Fröhlich, Holger

Published
2021
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23. The protective effect of tumor necrosis factor-alpha inhibitors in COVID-19 in patients with inflammatory rheumatic diseases compared to the general population—A comparison of two German registries

Author

Hasseli, Rebecca, primary, Hanses, Frank, additional, Stecher, Melanie, additional, Specker, Christof, additional, Weise, Tobias, additional, Borgmann, Stefan, additional, Hasselberger, Martina, additional, Hertenstein, Bernd, additional, Hower, Martin, additional, Hoyer, Bimba F., additional, Koll, Carolin, additional, Krause, Andreas, additional, von Lilienfeld-Toal, Marie, additional, Lorenz, Hanns-Martin, additional, Merle, Uta, additional, Nunes de Miranda, Susana M., additional, Pletz, Mathias W., additional, Regierer, Anne C., additional, Richter, Jutta G., additional, Rieg, Siegbert, additional, Roemmele, Christoph, additional, Ruethrich, Maria M., additional, Schmeiser, Tim, additional, Schulze-Koops, Hendrik, additional, Strangfeld, Anja, additional, Vehreschild, Maria J.G.T., additional, Voit, Florian, additional, Voll, Reinhard E., additional, Vehreschild, Jörg Janne, additional, Müller-Ladner, Ulf, additional, and Pfeil, Alexander, additional

Published
2024
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25. Primary prophylaxis of bacterial infections and Pneumocystis jirovecii pneumonia in patients with hematologic malignancies and solid tumors: 2020 updated guidelines of the Infectious Diseases Working Party of the German Society of Hematology and Medical Oncology (AGIHO/DGHO)

Author

Classen, Annika Y., Henze, Larissa, von Lilienfeld-Toal, Marie, Maschmeyer, Georg, Sandherr, Michael, Graeff, Luisa Durán, Alakel, Nael, Christopeit, Maximilian, Krause, Stefan W., Mayer, Karin, Neumann, Silke, Cornely, Oliver A., Penack, Olaf, Weißinger, Florian, Wolf, Hans-Heinrich, and Vehreschild, Jörg Janne

Published
2021
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26. First results of the “Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS)”

Author

Jakob, Carolin E. M., Borgmann, Stefan, Duygu, Fazilet, Behrends, Uta, Hower, Martin, Merle, Uta, Friedrichs, Anette, Tometten, Lukas, Hanses, Frank, Jung, Norma, Rieg, Siegbert, Wille, Kai, Grüner, Beate, Klinker, Hartwig, Gersbacher-Runge, Nicole, Hellwig, Kerstin, Eberwein, Lukas, Dolff, Sebastian, Rauschning, Dominic, von Bergwelt-Baildon, Michael, Lanznaster, Julia, Strauß, Richard, Trauth, Janina, de With, Katja, Ruethrich, Maria, Lueck, Catherina, Nattermann, Jacob, Tscharntke, Lene, Pilgram, Lisa, Fuhrmann, Sandra, Classen, Annika, Stecher, Melanie, Schons, Maximilian, Spinner, Christoph, and Vehreschild, Jörg Janne

Published
2021
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27. Chronic Liver Enzyme Elevation and Use of Contemporary ARVs Among People With HIV.

Author

Roen, Ashley O, Peters, Lars, Wandeler, Gilles, van der Valk, Marc, Zangerle, Robert, Günthard, Huldrych F, Wit, Ferdinand, Mussini, Cristina, Wit, Stéphane De, Monforte, Antonella d'Arminio, Vehreschild, Jörg Janne, Castagna, Antonella, Jaschinski, Nadine, Vannappagari, Vani, Chen, Linda, Tallada, Joan, C'mar, John, Mocroft, Amanda, and Ryom, Lene

Subjects
LIVER enzymes, HIV-positive persons, NON-nucleoside reverse transcriptase inhibitors, POISSON regression, ANTIRETROVIRAL agents
Abstract

Background While use of some older antiretroviral drugs (ARVs) is associated with chronic liver enzyme elevation (cLEE), the impact of newer ARVs remains unknown. Methods People with HIV enrolled in the RESPOND cohort who started an ARV after January 1, 2012 were included (baseline). The primary outcome was first cLEE individuals were censored at first of cLEE, last visit, death, or December 31, 2021. Incidence rates (IRs; events/1000 person-years) were calculated for each ARV overall and by ARV exposure (6–12 months, 1–2 years, and 2+ years). Poisson regression was used to estimate the incidence rate ratio (IRR) of cLEE and its association with individual ARVs and ARV class. Results Of 17 106 individuals included contributing 87 924 person-years of follow-up, 1932 (11.3%) experienced cLEE (incidence rate [IR], 22.0; 95% CI, 21.0–23.0). There was no evidence of a cumulative ARV effect on cLEE incidence, (6–12 months: IR, 45.8; 95% CI, 41.4–50.19; 1–2 years: IR, 34.3; 95% CI, 31.5–37.4; and 2+ years: IR, 18.5; 95% CI, 17.4–19.7). Any use (vs no prior use) of non-nucleoside reverse transcriptase inhibitors (NNRTIs) as a class and tenofovir disoproxil fumarate (TDF) was independently associated with an increased IRR of cLEE, and any use of darunavir (DRV) was associated with a decreased risk of cLEE. Conclusions cLEE is common and more frequent during the first year after initiating new ARVs. With a >5-year median follow-up, we found no short-term liver safety concerns with the use of INSTIs. Use of NNRTIs and TDF was associated with an increased cLEE risk, while DRV was associated with lower risk. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Measures of Longitudinal Immune Dysfunction and Risk of AIDS and Non-AIDS Defining Malignancies in Antiretroviral-Treated People With Human Immunodeficiency Virus.

Author

Chammartin, Frédérique, Mocroft, Amanda, Egle, Alexander, Zangerle, Robert, Smith, Colette, Mussini, Cristina, Wit, Ferdinand, Vehreschild, Jörg Janne, Monforte, Antonella d'Arminio, Castagna, Antonella, Bailly, Laurent, Bogner, Johannes, Wit, Stéphane de, Matulionyte, Raimonda, Law, Matthew, Svedhem, Veronica, Tallada, Joan, Garges, Harmony P, Marongiu, Andrea, and Borges, Álvaro H

Subjects
RISK assessment, ANTIRETROVIRAL agents, T cells, VIRAL load, RESEARCH funding, CD4 lymphocyte count, SCIENTIFIC observation, HIV infections, DESCRIPTIVE statistics, PSYCHOLOGY of HIV-positive persons, TUMORS, CONFIDENCE intervals, AIDS, PROPORTIONAL hazards models, DISEASE complications
Abstract

Background Human immunodeficiency virus (HIV) infection leads to chronic immune activation/inflammation that can persist in virally suppressed persons on fully active antiretroviral therapy (ART) and increase risk of malignancies. The prognostic role of low CD4:CD8 ratio and elevated CD8 cell counts on the risk of cancer remains unclear. Methods We investigated the association of CD4:CD8 ratio on the hazard of non-AIDS defining malignancy (NADM), AIDS-defining malignancy (ADM) and most frequent group of cancers in ART-treated people with HIV (PWH) with a CD4 and CD8 cell counts and viral load measurements at baseline. We developed Cox proportional hazard models with adjustment for known confounders of cancer risk and time-dependent cumulative and lagged exposures of CD4:CD8 ratio to account for time-evolving risk factors and avoid reverse causality. Results CD4:CD8 ratios below 0.5, compared to above 1.0, were independently associated with a 12-month time-lagged higher risk of ADM and infection-related malignancies (adjusted hazard ratio 2.61 [95% confidence interval {CI }1.10–6.19] and 2.03 [95% CI 1.24–3.33], respectively). CD4 cell counts below 350 cells/μL were associated with an increased risk of NADMs and ADMs, as did infection, smoking, and body mass index-related malignancies. Conclusions In ART-treated PWH low CD4:CD8 ratios were associated with ADM and infection-related cancers independently from CD4 and CD8 cell counts and may alert clinicians for cancer screening and prevention of NADM. [ABSTRACT FROM AUTHOR]

Published
2024
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30. COVID-19 in patients with active - higher inflammatory activity predicts poor outcome.

Author

Rüthrich, Maria Madeleine, primary, Khodamoradi, Yascha, additional, Lanznaster, Julia, additional, Stecher, Melanie, additional, Tometten, Lukas, additional, Voit, Florian, additional, Koll, Carolin E.M., additional, Borgmann, Stefan, additional, Vehreschild, Jörg Janne, additional, Ole Jensen, Björn-Erik, additional, Hanses, Frank, additional, Giessen-Jung, Clemens, additional, Wille, Kai, additional, von Lilienfeld-Toal, Marie, additional, and Beutel, Gernot, additional

Published
2023
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31. Clostridioides difficile infection (CDI): A pan-European multi-center cost and resource utilization study, results from the Combatting Bacterial Resistance in Europe CDI (COMBACTE-CDI)

Author

Academic Partners, Bonten, Marc, Davies, Kerrie A., Wilcox, Mark H., Kuijper, Ed, Rupnik, Maja, Wingen-Heimann, Sebastian, Tacconelli, Evelina, Vilken, Tuba, Petrosillo, Nicola, EFPIA Partners, Pfizer Ltd, GlaxoSmithKline, bioMérieux, Pasteur, Sanofi, Da Volterra, The Management Board of COMBACTE-CDI, Cleuziat, Philippe, Webber, Chris, Wingen-Heimann, Sebastian M., Davies, Kerrie, Viprey, Virginie F., Davis, Georgina, Vehreschild, Maria J.G.T., Lurienne, Lise, Bandinelli, Pierre-Alain, Cornely, Oliver A., Hopff, Sina M., and Vehreschild, Jörg Janne

Published
2023
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34. Infektionen bei Immunschwäche

Author

Claßen, Annika Y., primary, Cornely, Oliver A., additional, Hanses, Frank, additional, Köhler, Philipp, additional, Mellinghoff, Sibylle, additional, Vehreschild, Jörg Janne, additional, and Witzke, Oliver, additional

Published
2021
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36. COVID-19 in Patients with Active Cancer: Higher Inflammatory Activity Predicts Poor Outcome.

Author

Rüthrich, Maria Madeleine, Khodamoradi, Yascha, Lanznaster, Julia, Stecher, Melanie, Tometten, Lukas, Voit, Florian, Koll, Carolin E.M., Borgmann, Stefan, Vehreschild, Jörg Janne, Ole Jensen, Björn-Erik, Hanses, Frank, Giessen-Jung, Clemens, Wille, Kai, von Lilienfeld-Toal, Marie, and Beutel, Gernot

Subjects
COVID-19, CANCER patients, MORTALITY risk factors, DEATH rate, REGRESSION analysis
Abstract

Introduction: Active malignancies have been identified as an independent risk factor for severity and mortality in COVID-19. However, direct comparisons between SARS-CoV-2-infected patients with active (acP) and non-active cancers (n-acP) remain scarce. Patients and Methods: We retrospectively analyzed a cohort of cancer patients with PCR-confirmed SARS-CoV-2 infection, enrolled from March 16, 2020, to July 31, 2021. Data on demographics, cancer, and laboratory findings were collected. Descriptive and subsequent regression analyses were performed. Endpoints were "deterioration to severe COVID-19" and "infection-associated mortality." Results: In total, 987 cancer patients (510 acP vs. 477 n-acP) were included in our analysis. The majority was >55 years old, more men than women were included. At detection of SARS-CoV-2, 65.5% of patients had mild/moderate symptoms, while deterioration to severe COVID-19 was slightly more common in acP (19 vs. 16%; p = 0.284). COVID-19-associated mortality was significantly higher in acP (24 vs. 17.5%, p < 0.001). In terms of laboratory tests, severe cytopenia and elevated levels of inflammatory markers were common findings in acP at baseline, particularly in those who developed a severe infection or died. Multivariate analysis revealed that ferritin (HR 14.24 [2.1–96], p = 0.006) and CRP (HR 2.85 [1.02–8.02], p = 0.046) were associated with severity and mortality. In n-acP, association was seen for ferritin only (HR 4.1 [1.51–11.17], p = 0.006). Conclusion: Comparing patients with active and non-active cancer, the former showed higher mortality rates. Also, inflammatory markers were significantly increased, assuming higher levels of inflammation may play a role in the adverse outcome of COVID-19 in aCP. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Concepts of lines of therapy in cancer treatment: Findings from an expert interview-based study

Author

Falchetto, Lisa, primary, Bender, Bernd, additional, Erhard, Ian, additional, Zeiner, Kim N., additional, Stratmann, Jan A., additional, Koll, Florestan J., additional, Wagner, Sebastian, additional, Reiser, Marcel, additional, Gasimli, Khayal, additional, Stehle, Angelika, additional, Voss, Martin, additional, Ballo, Olivier, additional, Vehreschild, Jörg Janne, additional, and Maier, Daniel, additional

Published
2023
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38. Interoperable, Domain-Specific Extensions for the German Corona Consensus (GECCO) COVID-19 Research Data Set Using an Interdisciplinary, Consensus-Based Workflow: Data Set Development Study

Author

Lichtner, Gregor, primary, Haese, Thomas, additional, Brose, Sally, additional, Röhrig, Larissa, additional, Lysyakova, Liudmila, additional, Rudolph, Stefanie, additional, Uebe, Maria, additional, Sass, Julian, additional, Bartschke, Alexander, additional, Hillus, David, additional, Kurth, Florian, additional, Sander, Leif Erik, additional, Eckart, Falk, additional, Toepfner, Nicole, additional, Berner, Reinhard, additional, Frey, Anna, additional, Dörr, Marcus, additional, Vehreschild, Jörg Janne, additional, von Kalle, Christof, additional, and Thun, Sylvia, additional

Published
2023
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39. Duration of Protection From Pneumonia After Pneumococcal Vaccination in Hemodialysis Patients (DOPPIO): Protocol for a Prospective Multicenter Study

Author

Mellinghoff, Sibylle, primary, von Gersdorff, Gero, additional, Bruns, Caroline, additional, Albus, Kerstin, additional, Dimitriou, Vassiliki, additional, Steinbach, Angela, additional, Schaller, Mathias, additional, Vehreschild, Jörg Janne, additional, Cornely, Oliver A, additional, and Liss, Blasius Janusch, additional

Published
2023
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43. Increased circulating fibronectin, depletion of natural IgM and heightened EBV, HSV-1 reactivation in ME/CFS and long COVID

Author

Liu, Zheng, primary, Hollmann, Claudia, additional, Kalanidhi, Sharada, additional, Grothey, Arnhild, additional, Keating, Sam, additional, Mena-Palomo, Irene, additional, Lamer, Stephanie, additional, Schlosser, Andreas, additional, Kaiping, Agnes, additional, Scheller, Carsten, additional, Sotzny, Franzeska, additional, Horn, Anna, additional, Nürnberger, Carolin, additional, Cejka, Vladimir, additional, Afshar, Boshra, additional, Bahmer, Thomas, additional, Schreiber, Stefan, additional, Vehreschild, Jörg Janne, additional, Miljukov, Olga, additional, Schäfer, Christian, additional, Kretzler, Luzie, additional, Keil, Thomas, additional, Reese, Jens-Peter, additional, Eichner, Felizitas A, additional, Schmidbauer, Lena, additional, Heuschmann, Peter U, additional, Störk, Stefan, additional, Morbach, Caroline, additional, Riemekasten, Gabriela, additional, Beyersdorf, Niklas, additional, Scheibenbogen, Carmen, additional, Naviaux, Robert K, additional, Williams, Marshall, additional, Ariza, Maria E, additional, and Prusty, Bhupesh K, additional

Published
2023
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45. SARS-CoV-2 infection in chronic kidney disease patients with pre-existing dialysis: description across different pandemic intervals and effect on disease course (mortality)

Author

Pilgram, Lisa, Eberwein, Lukas, Jensen, Bjoern-Erik O., Jakob, Carolin E. M., Koehler, Felix C., Hower, Martin, Kielstein, Jan T., Stecher, Melanie, Hohenstein, Bernd, Prasser, Fabian, Westhoff, Timm, de Miranda, Susana M. Nunes, Vehreschild, Maria J. G. T., Lanznaster, Julia, Dolff, Sebastian, Spinner, Christoph, Ruethrich, Maria Madeleine, Tometten, Lukas, Borgmann, Stefan, Jung, Norma, Hertenstein, Bernd, Degenhardt, Christian, Voigt, Ingo, Hanses, Frank, Wille, Kai, vom Dahl, Jürgen, Rothfuss, Katja, Hellwig, Kerstin, Rupp, Jan, Isberner, Nora, Nattermann, Jacob, Strauss, Richard, Göpel, Siri, Vehreschild, Jörg Janne, Schulze, Nick, Fuhrmann, Sandra, Schons, Max, Claßen, Annika, and Franke, Bernd

Subjects
Microbiology (medical), Infectious Diseases, Medizin, General Medicine
Abstract

Purpose Patients suffering from chronic kidney disease (CKD) are in general at high risk for severe coronavirus disease (COVID-19) but dialysis-dependency (CKD5D) is poorly understood. We aimed to describe CKD5D patients in the different intervals of the pandemic and to evaluate pre-existing dialysis dependency as a potential risk factor for mortality. Methods In this multicentre cohort study, data from German study sites of the Lean European Open Survey on SARS-CoV-2-infected patients (LEOSS) were used. We multiply imputed missing data, performed subsequent analyses in each of the imputed data sets and pooled the results. Cases (CKD5D) and controls (CKD not requiring dialysis) were matched 1:1 by propensity-scoring. Effects on fatal outcome were calculated by multivariable logistic regression. Results The cohort consisted of 207 patients suffering from CKD5D and 964 potential controls. Multivariable regression of the whole cohort identified age (> 85 years adjusted odds ratio (aOR) 7.34, 95% CI 2.45–21.99), chronic heart failure (aOR 1.67, 95% CI 1.25–2.23), coronary artery disease (aOR 1.41, 95% CI 1.05–1.89) and active oncological disease (aOR 1.73, 95% CI 1.07–2.80) as risk factors for fatal outcome. Dialysis-dependency was not associated with a fatal outcome—neither in this analysis (aOR 1.08, 95% CI 0.75–1.54) nor in the conditional multivariable regression after matching (aOR 1.34, 95% CI 0.70–2.59). Conclusions In the present multicentre German cohort, dialysis dependency is not linked to fatal outcome in SARS-CoV-2-infected CKD patients. However, the mortality rate of 26% demonstrates that CKD patients are an extreme vulnerable population, irrespective of pre-existing dialysis-dependency.

Published
2022

46. Profile of the Multicenter Cohort of the German Cancer Consortium’s Clinical Communication Platform

Author

Maier, Daniel, primary, Vehreschild, Jörg Janne, additional, Uhl, Barbara, additional, Meyer, Sandra, additional, Berger-Thürmel, Karin, additional, Boerries, Melanie, additional, Braren, Rikmer, additional, Grünwald, Viktor, additional, Hadaschik, Boris, additional, Palm, Stefan, additional, Singer, Susanne, additional, Stuschke, Martin, additional, Juárez, David, additional, Delpy, Pierre, additional, Lambarki, Mohammed, additional, Hummel, Michael, additional, Engels, Cäcilia, additional, Andreas, Stefanie, additional, Gökbuget, Nicola, additional, Ihrig, Kristina, additional, Burock, Susen, additional, Keune, Dietmar, additional, Eggert, Angelika, additional, Keilholz, Ulrich, additional, Schulz, Hagen, additional, Büttner, Daniel, additional, Löck, Steffen, additional, Krause, Mechthild, additional, Esins, Mirko, additional, Ressing, Frank, additional, Schuler, Martin, additional, Brandts, Christian, additional, Brucker, Daniel P, additional, Husmann, Gabriele, additional, Oellerich, Thomas, additional, Metzger, Patrick, additional, Voigt, Frederik, additional, Illert, Anna L, additional, Theobald, Matthias, additional, Kindler, Thomas, additional, Sudhof, Ursula, additional, Reckmann, Achim, additional, Schwinghammer, Felx, additional, Nasseh, Daniel, additional, Weichert, Wilko, additional, von Bergwelt-Baildon, Michael, additional, Bitzer, Michael, additional, Malek, Nisar, additional, Öner, Öznur, additional, Schulze-Osthoff, Klaus, additional, Bartels, Stefan, additional, Haier, Jörg, additional, Ammann, Raimund, additional, Schmidt, Anja Franziska, additional, Guenther, Bernd, additional, Janning, Melanie, additional, Kasper, Bernd, additional, Loges, Sonja, additional, Stilgenbauer, Stephan, additional, Kuhn, Peter, additional, Tausch, Eugen, additional, Runow, Silvana, additional, Kerscher, Alexander, additional, Neumann, Michael, additional, Breu, Martin, additional, Lablans, Martin, additional, and Serve, Hubert, additional

Published
2023
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47. Duration of Protection From Pneumonia After Pneumococcal Vaccination in Hemodialysis Patients (DOPPIO): Protocol for a Prospective Multicenter Study (Preprint)

Author

Mellinghoff, Sibylle, primary, von Gersdorff, Gero, additional, Bruns, Caroline, additional, Albus, Kerstin, additional, Dimitriou, Vassiliki, additional, Steinbach, Angela, additional, Schaller, Mathias, additional, Vehreschild, Jörg Janne, additional, Cornely, Oliver A, additional, and Liss, Blasius Janusch, additional

Published
2023
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48. No Increased Lethality in Covid-19 in Patients with Inflammatory Rheumatic Diseases Compared to the General Population - a Comparison of Two German Registries -

Author

Hasseli, Rebecca, primary, Hanses, Frank, additional, Stecher, Melanie, additional, Specker, Christof, additional, Weise, Tobias, additional, Borgmann, Stefan, additional, Haselberger, Martina, additional, Hertenstein, Bernd, additional, Hower, Martin, additional, Hoyer, Bimba Franziska, additional, Koll, Carolin, additional, Krause, Andreas, additional, von Lilienfeld-Toal, Marie, additional, Lorenz, Hanns-Martin, additional, Merle, Uta, additional, Nunes de Miranda, Susana M., additional, Pletz, Mathias W., additional, Regierer, Anne, additional, Richter, Jutta G., additional, Rieg, Siegbert R., additional, Römmele, Christoph, additional, Rüthrich, Maria M., additional, Schulze-Koops, Hendrik, additional, Strangfeld, Anja, additional, Vehreschild, Maria, additional, Voit, Florian, additional, Voll, Reinhard, additional, Vehreschild, Jörg Janne, additional, Leipsic, Jonathon, additional, and Pfeil, Alexander, additional

Published
2023
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49. Adressen

Author

Lehmann, Clara, primary, Ruf, Bernhard R., additional, Jung, Norma, additional, Böll, Boris, additional, Boesecke, Christoph, additional, Breuninger, Marianne, additional, Cornely, Oliver A., additional, Draenert, Rika, additional, Graeff, Luisa Durán, additional, Fätkenheuer, Gerd, additional, Fischer, Julia, additional, Gielen, Jörg, additional, Gillor, Daniel, additional, Glück, Thomas, additional, Grajewski, Rafael S., additional, Gruell, Henning, additional, Hagel, Stefan, additional, Hamacher, Laura, additional, Hamprecht, Axel, additional, Hanses, Frank, additional, Hitzenbichler, Florian, additional, Huth, Alexandra, additional, Jansen, Stefanie, additional, Jazmati, Nathalie, additional, Kaasch, Achim J., additional, Kastenbauer, Ulrich, additional, Kochanek, Matthias, additional, Köhler, Carsten, additional, Köhler, Philipp, additional, Lehmann, Helmar C., additional, Lehmann, Lorenz H., additional, Lichtenstein, Thorsten, additional, Lüers, Jan-Christoffer, additional, Meller, Stephan, additional, Metzger, Wolfram, additional, Nierhoff, Dirk, additional, Otto-Lambertz, Christina, additional, Platten, Martin, additional, Reuter, Stefan, additional, Rieg, Siegbert, additional, Roehr, Philipp, additional, Rybniker, Jan, additional, Schlaak, Max, additional, Schmiedel, Stefan, additional, Schulze zur Wiesch, Julian, additional, Schwarze-Zander, Carolynne, additional, Seybold, Ulrich, additional, Shimabukuro-Vornhagen, Alexander, additional, Spinner, Christoph D., additional, Sprenger, Alina, additional, Stephan, Christoph, additional, Suárez, Isabelle, additional, Vehreschild, Jörg Janne, additional, Vehreschild, Maria, additional, Wassilew, Nasstasja, additional, Wieland, Ulrike, additional, Witzke, Oliver, additional, and Wolf, Timo, additional

Published
2018
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50. Prognostic accuracy of SOFA, qSOFA and SIRS criteria in hematological cancer patients: a retrospective multicenter study

Author

Probst, Lucie, Schalk, Enrico, Liebregts, Tobias, Zeremski, Vanja, Tzalavras, Asterios, von Bergwelt-Baildon, Michael, Hesse, Nina, Prinz, Johanna, Vehreschild, Jörg Janne, Shimabukuro-Vornhagen, Alexander, Eichenauer, Dennis A., Garcia Borrega, Jorge, Kochanek, Matthias, Böll, Boris, and for the Working Party on Intensive Care Medicine in Hematologic and Oncologic Patients (iCHOP) of the German Society of Hematology and Medical Oncology (DGHO)

Published
2019
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