343 results on '"Vehreschild, Jörg Janne"'
Search Results
2. Role and benefits of infectious diseases specialists in the COVID-19 pandemic: Multilevel analysis of care provision in German hospitals using data from the Lean European Open Survey on SARS-CoV-2 infected patients (LEOSS) cohort
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Tscharntke, Lene T., Jung, Norma, Hanses, Frank, Koll, Carolin E. M., Pilgram, Lisa, Rieg, Siegbert, Borgmann, Stefan, de Miranda, Susana M. Nunes, Scherer, Margarete, Spinner, Christoph D., Rüthrich, Maria, Vehreschild, Maria J. G. T., von Bergwelt-Baildon, Michael, Wille, Kai, Merle, Uta, Hower, Martin, Rothfuss, Katja, Nadalin, Silvio, Klinker, Hartwig, Fürst, Julia, Greiffendorf, Ingo, Raichle, Claudia, Friedrichs, Anette, Rauschning, Dominic, de With, Katja, Eberwein, Lukas, Riedel, Christian, Milovanovic, Milena, Worm, Maximilian, Schultheis, Beate, Schubert, Jörg, Bota, Marc, Beutel, Gernot, Glück, Thomas, Schmid, Michael, Wintermantel, Tobias, Peetz, Helga, Steiner, Stephan, Ribel, Elena, Schäfer, Harald, Vehreschild, Jörg Janne, and Stecher, Melanie
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- 2024
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3. Incidence and risk factors for HIV-tuberculosis coinfection in the Cologne–Bonn region: a retrospective cohort study
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Suárez, Isabelle, Rauschning, Dominic, Schüller, Cora, Hagemeier, Anna, Stecher, Melanie, Lehmann, Clara, Schommers, Philipp, Schlabe, Stefan, Vehreschild, Jörg-Janne, Koll, Carolin, Schwarze-Zander, Carolynne, Wasmuth, Jan-Christian, Klingmüller, Angela, Rockstroh, Jürgen Kurt, Fätkenheuer, Gerd, Boesecke, Christoph, and Rybniker, Jan
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- 2024
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4. A precise performance-based reimbursement model for the multi-centre NAPKON cohorts – development and evaluation
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Appel, Katharina S., Lee, Chin Huang, Nunes de Miranda, Susana M., Maier, Daniel, Reese, Jens-Peter, Anton, Gabriele, Bahmer, Thomas, Ballhausen, Sabrina, Balzuweit, Beate, Bellinghausen, Carla, Blumentritt, Arne, Brechtel, Markus, Chaplinskaya-Sobol, Irina, Erber, Johanna, Fiedler, Karin, Geisler, Ramsia, Heyder, Ralf, Illig, Thomas, Kohls, Mirjam, Kollek, Jenny, Krist, Lilian, Lorbeer, Roberto, Miljukov, Olga, Mitrov, Lazar, Nürnberger, Carolin, Pape, Christian, Pley, Christina, Schäfer, Christian, Schaller, Jens, Schattschneider, Mario, Scherer, Margarete, Schulze, Nick, Stahl, Dana, Stubbe, Hans Christian, Tamminga, Thalea, Tebbe, Johannes Josef, Vehreschild, Maria J. G. T., Wiedmann, Silke, and Vehreschild, Jörg Janne
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- 2024
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5. Development of a long noncoding RNA-based machine learning model to predict COVID-19 in-hospital mortality
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Devaux, Yvan, Zhang, Lu, Lumley, Andrew I., Karaduzovic-Hadziabdic, Kanita, Mooser, Vincent, Rousseau, Simon, Shoaib, Muhammad, Satagopam, Venkata, Adilovic, Muhamed, Srivastava, Prashant Kumar, Emanueli, Costanza, Martelli, Fabio, Greco, Simona, Badimon, Lina, Padro, Teresa, Lustrek, Mitja, Scholz, Markus, Rosolowski, Maciej, Jordan, Marko, Brandenburger, Timo, Benczik, Bettina, Agg, Bence, Ferdinandy, Peter, Vehreschild, Jörg Janne, Lorenz-Depiereux, Bettina, Dörr, Marcus, Witzke, Oliver, Sanchez, Gabriel, Kul, Seval, Baker, Andy H., Fagherazzi, Guy, Ollert, Markus, Wereski, Ryan, Mills, Nicholas L., and Firat, Hüseyin
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- 2024
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6. Concepts of lines of therapy in cancer treatment: findings from an expert interview-based study
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Falchetto, Lisa, Bender, Bernd, Erhard, Ian, Zeiner, Kim N., Stratmann, Jan A., Koll, Florestan J., Wagner, Sebastian, Reiser, Marcel, Gasimli, Khayal, Stehle, Angelika, Voss, Martin, Ballo, Olivier, Vehreschild, Jörg Janne, and Maier, Daniel
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- 2024
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7. Cancer incidence and digital information seeking in Germany: a retrospective observational study
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Wecker, Hannah, Maier, Daniel, Ziehfreund, Stefanie, Fox, Fabienne A. U., Erhard, Ian, Vehreschild, Jörg Janne, and Zink, Alexander
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- 2024
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8. Persistent symptoms and risk factors predicting prolonged time to symptom-free after SARS‑CoV‑2 infection: an analysis of the baseline examination of the German COVIDOM/NAPKON-POP cohort
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Shi, Yanyan, Strobl, Ralf, Apfelbacher, Christian, Bahmer, Thomas, Geisler, Ramsia, Heuschmann, Peter, Horn, Anna, Hoven, Hanno, Keil, Thomas, Krawczak, Michael, Krist, Lilian, Lemhöfer, Christina, Lieb, Wolfgang, Lorenz-Depiereux, Bettina, Mikolajczyk, Rafael, Montellano, Felipe A., Reese, Jens Peter, Schreiber, Stefan, Skoetz, Nicole, Störk, Stefan, Vehreschild, Jörg Janne, Witzenrath, Martin, and Grill, Eva
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- 2023
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9. Depression and fatigue six months post-COVID-19 disease are associated with overlapping symptom constellations: A prospective, multi-center, population-based cohort study
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Weiß, Martin, Gutzeit, Julian, Appel, Katharina S., Bahmer, Thomas, Beutel, Manfred, Deckert, Jürgen, Fricke, Julia, Hanß, Sabine, Hettich-Damm, Nora, Heuschmann, Peter U., Horn, Anna, Jauch-Chara, Kamila, Kohls, Mirjam, Krist, Lilian, Lorenz-Depiereux, Bettina, Otte, Christian, Pape, Daniel, Reese, Jens-Peter, Schreiber, Stefan, Störk, Stefan, Vehreschild, Jörg Janne, and Hein, Grit
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- 2024
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10. Profile of the multicenter cohort of the German Cancer Consortium’s Clinical Communication Platform
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Maier, Daniel, Vehreschild, Jörg Janne, Uhl, Barbara, Meyer, Sandra, Berger-Thürmel, Karin, Boerries, Melanie, Braren, Rickmer, Grünwald, Viktor, Hadaschik, Boris, Palm, Stefan, Singer, Susanne, Stuschke, Martin, Juárez, David, Delpy, Pierre, Lambarki, Mohamed, Hummel, Michael, Engels, Cäcilia, Andreas, Stefanie, Gökbuget, Nicola, Ihrig, Kristina, Burock, Susen, Keune, Dietmar, Eggert, Angelika, Keilholz, Ulrich, Schulz, Hagen, Büttner, Daniel, Löck, Steffen, Krause, Mechthild, Esins, Mirko, Ressing, Frank, Schuler, Martin, Brandts, Christian, Brucker, Daniel P., Husmann, Gabriele, Oellerich, Thomas, Metzger, Patrick, Voigt, Frederik, Illert, Anna L., Theobald, Matthias, Kindler, Thomas, Sudhof, Ursula, Reckmann, Achim, Schwinghammer, Felix, Nasseh, Daniel, Weichert, Wilko, von Bergwelt-Baildon, Michael, Bitzer, Michael, Malek, Nisar, Öner, Öznur, Schulze-Osthoff, Klaus, Bartels, Stefan, Haier, Jörg, Ammann, Raimund, Schmidt, Anja Franziska, Guenther, Bernd, Janning, Melanie, Kasper, Bernd, Loges, Sonja, Stilgenbauer, Stephan, Kuhn, Peter, Tausch, Eugen, Runow, Silvana, Kerscher, Alexander, Neumann, Michael, Breu, Martin, Lablans, Martin, and Serve, Hubert
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- 2023
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11. Drug Resistance Spread in 6 Metropolitan Regions, Germany, 2001-20181.
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Stecher, Melanie, Chaillon, Antoine, Stephan, Christoph, Knops, Elena, Kohmer, Niko, Lehmann, Clara, Eberle, Josef, Bogner, Johannes, Spinner, Christoph D, Eis-Hübinger, Anna Maria, Wasmuth, Jan-Christian, Schäfer, Guido, Behrens, Georg, Mehta, Sanjay R, Vehreschild, Jörg Janne, and Hoenigl, Martin
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ART ,Germany ,HIV transmission ,antimicrobial resistance ,antiretroviral therapy ,mutations ,phylogenetic analysis ,public health ,Microbiology ,Clinical Sciences ,Medical Microbiology ,Public Health and Health Services - Abstract
We analyzed 1,397 HIV-1 pol sequences of antiretroviral therapy-naive patients in a total of 7 university hospitals in Bonn, Cologne, Frankfurt, Hamburg, Hannover, and Munich, Germany. Phylogenetic and network analysis elucidated numerous cases of shared drug resistance mutations among genetically linked patients; K103N was the most frequently shared mutation.
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- 2020
12. Frequently asked questions regarding SARS-CoV-2 in cancer patients-recommendations for clinicians caring for patients with malignant diseases.
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von Lilienfeld-Toal, Marie, Vehreschild, Jörg Janne, Cornely, Oliver, Pagano, Livio, Compagno, Francesca, EHA Infectious Disease Scientific Working Group, and Hirsch, Hans H
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EHA Infectious Disease Scientific Working Group ,Humans ,Pneumonia ,Viral ,Coronavirus Infections ,Neoplasms ,Patient Care ,Infection Control ,Practice Guidelines as Topic ,Infectious Disease Transmission ,Patient-to-Professional ,Pandemics ,Betacoronavirus ,COVID-19 ,SARS-CoV-2 ,Rare Diseases ,Cancer ,Clinical Research ,Infectious Diseases ,Patient Safety ,Vaccine Related ,Prevention ,Hematology ,Biodefense ,Lung ,Emerging Infectious Diseases ,Infection ,Good Health and Well Being ,Clinical Sciences ,Oncology and Carcinogenesis ,Immunology - Abstract
Since early 2020, the SARS-CoV-2 pandemic has a massive impact on health care systems worldwide. Patients with malignant diseases are assumed to be at increased risk for a worse outcome of SARS-CoV-2 infection, and therefore, guidance regarding prevention and management of the infection as well as safe administration of cancer-therapy is required. Here, we provide recommendations for the management of patients with malignant disease in the times of COVID-19. These recommendations were prepared by an international panel of experts and then consented by the EHA Scientific Working Group on Infection in Hematology. The primary aim is to enable clinicians to provide optimal cancer care as safely as possible, since the most important protection for patients with malignant disease is the best-possible control of the underlying disease.
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- 2020
13. Chronic liver enzyme elevation and use of contemporary ARVs among persons living with HIV
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Roen, Ashley O, primary, Peters, Lars, additional, Wandeler, Gilles, additional, van der Valk, Marc, additional, Zangerle, Robert, additional, Günthard, Huldrych F, additional, Wit, Ferdinand, additional, Mussini, Cristina, additional, De Wit, Stéphane, additional, d’Arminio Monforte, Antonella, additional, Vehreschild, Jörg Janne, additional, Castagna, Antonella, additional, Jaschinski, Nadine, additional, Vannappagari, Vani, additional, Chen, Linda, additional, Tallada, Joan, additional, C’mar, John, additional, Mocroft, Amanda, additional, and Ryom, Lene, additional
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- 2024
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14. The German National Pandemic Cohort Network (NAPKON): rationale, study design and baseline characteristics
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Schons, Maximilian, Pilgram, Lisa, Reese, Jens-Peter, Stecher, Melanie, Anton, Gabriele, Appel, Katharina S., Bahmer, Thomas, Bartschke, Alexander, Bellinghausen, Carla, Bernemann, Inga, Brechtel, Markus, Brinkmann, Folke, Brünn, Clara, Dhillon, Christine, Fiessler, Cornelia, Geisler, Ramsia, Hamelmann, Eckard, Hansch, Stefan, Hanses, Frank, Hanß, Sabine, Herold, Susanne, Heyder, Ralf, Hofmann, Anna-Lena, Hopff, Sina Marie, Horn, Anna, Jakob, Carolin, Jiru-Hillmann, Steffi, Keil, Thomas, Khodamoradi, Yascha, Kohls, Mirjam, Kraus, Monika, Krefting, Dagmar, Kunze, Sonja, Kurth, Florian, Lieb, Wolfgang, Lippert, Lena Johanna, Lorbeer, Roberto, Lorenz-Depiereux, Bettina, Maetzler, Corina, Miljukov, Olga, Nauck, Matthias, Pape, Daniel, Püntmann, Valentina, Reinke, Lennart, Römmele, Christoph, Rudolph, Stefanie, Sass, Julian, Schäfer, Christian, Schaller, Jens, Schattschneider, Mario, Scheer, Christian, Scherer, Margarete, Schmidt, Sein, Schmidt, Julia, Seibel, Kristina, Stahl, Dana, Steinbeis, Fridolin, Störk, Stefan, Tauchert, Maike, Tebbe, Johannes Josef, Thibeault, Charlotte, Toepfner, Nicole, Ungethüm, Kathrin, Vadasz, Istvan, Valentin, Heike, Wiedmann, Silke, Zoller, Thomas, Nagel, Eike, Krawczak, Michael, von Kalle, Christof, Illig, Thomas, Schreiber, Stefan, Witzenrath, Martin, Heuschmann, Peter, and Vehreschild, Jörg Janne
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- 2022
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15. Hotspots of Transmission Driving the Local Human Immunodeficiency Virus Epidemic in the Cologne-Bonn Region, Germany
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Stecher, Melanie, Hoenigl, Martin, Eis-Hübinger, Anna Maria, Lehmann, Clara, Fätkenheuer, Gerd, Wasmuth, Jan-Christian, Knops, Elena, Vehreschild, Jörg Janne, Mehta, Sanjay, and Chaillon, Antoine
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Medical Microbiology ,Biomedical and Clinical Sciences ,HIV/AIDS ,Infectious Diseases ,Infection ,Good Health and Well Being ,Adult ,Epidemics ,Female ,Gene Flow ,Genes ,pol ,Genetic Linkage ,Germany ,HIV Infections ,HIV-1 ,Hospitals ,University ,Humans ,Male ,Middle Aged ,Multigene Family ,Phylogeography ,Public Health ,Retrospective Studies ,Sequence Analysis ,RNA ,Spatio-Temporal Analysis ,Travel ,HIV transmission ,geospatial dispersial ,phylogeographic analyses ,public health ,Biological Sciences ,Medical and Health Sciences ,Microbiology ,Clinical sciences - Abstract
BackgroundGeographical allocation of interventions focusing on hotspots of human immunodeficiency virus (HIV) transmission has the potential to improve efficiency. We used phylogeographic analyses to identify hotspots of the HIV transmission in Cologne-Bonn, Germany.MethodsWe included 714 HIV-1 infected individuals, followed up at the University Hospitals Cologne and Bonn. Distance-based molecular network analyses were performed to infer putative relationships. Characteristics of genetically linked individuals and assortativity (shared characteristics) were analyzed. Geospatial diffusion (ie, viral gene flow) was evaluated using a Slatkin-Maddison approach. Geospatial dispersal was determined by calculating the average distance between the residences of linked individuals (centroids of 3-digit zip code).ResultsIn sum, 217/714 (30.4%) sequences had a putative genetic linkage, forming 77 clusters (size range: 2-8). Linked individuals were more likely to live in areas surrounding the city center (P = .043),
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- 2019
16. The DKTK EXLIQUID consortium – exploiting liquid biopsies to advance cancer precision medicine for molecular tumor board patients
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Mack Matthias, Broche Julian, George Stephen, Hajjari Zahra, Janke Florian, Ranganathan Lavanya, Ashouri Mohammadreza, Bleul Sabine, Desuki Alexander, Engels Cecilia, Fliedner Stephanie M.J., Hartmann Nils, Hummel Michael, Janning Melanie, Kiel Alexander, Köhler Thomas, Koschade Sebastian, Lablans Martin, Lambarki Mohamed, Loges Sonja, Lueong Smiths, Meyer Sandra, Ossowski Stephan, Scherer Florian, Schroeder Christopher, Skowronek Patrick, Thiede Christian, Uhl Barbara, Vehreschild Jörg Janne, von Bubnoff Nikolas, Wagner Sebastian, Werner Tamara V., Westphalen C. Benedikt, Fresser Patrizia, Sültmann Holger, Tinhofer Ingeborg, and Winter Christof
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liquid profiling ,molecular profiling ,precision oncology ,Medical technology ,R855-855.5 - Abstract
Testing for genetic alterations in tumor tissue allows clinicians to identify patients who most likely will benefit from molecular targeted treatment. EXLIQUID – exploiting liquid biopsies to advance cancer precision medicine – investigates the potential of additional non-invasive tools for guiding therapy decisions and monitoring of advanced cancer patients. The term “liquid biopsy” (LB) refers to non-invasive analysis of tumor-derived circulating material such as cell-free DNA in blood samples from cancer patients. Although recent technological advances allow sensitive and specific detection of LB biomarkers, only few LB assays have entered clinical routine to date. EXLIQUID is a German Cancer Consortium (DKTK)-wide joint funding project that aims at establishing LBs as a minimally-invasive tool to analyze molecular changes in circulating tumor DNA (ctDNA). Here, we present the structure, clinical aim, and methodical approach of the new DKTK EXLIQUID consortium. Within EXLIQUID, we will set up a multicenter repository of high-quality LB samples from patients participating in DKTK MASTER and local molecular tumor boards, which use molecular profiles of tumor tissues to guide targeted therapies. We will develop LB assays for monitoring of therapy efficacy by the analysis of tumor mutant variants and tumor-specific DNA methylation patterns in ctDNA from these patients. By bringing together LB experts from all DKTK partner sites and exploiting the diversity of their particular expertise, complementary skills and technologies, the EXLIQUID consortium addresses the challenges of translating LBs into the clinic. The DKTK structure provides EXLIQUID a unique position for the identification of liquid biomarkers even in less common tumor types, thereby extending the group of patients benefitting from non-invasive LB testing. Besides its scientific aims, EXLIQUID is building a valuable precision oncology cohort and LB platform which will be available for future collaborative research studies within the DKTK and beyond.
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- 2022
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17. Severity, predictors and clinical correlates of Post-COVID syndrome (PCS) in Germany: A prospective, multi-centre, population-based cohort study
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Bahmer, Thomas, Borzikowsky, Christoph, Lieb, Wolfgang, Horn, Anna, Krist, Lilian, Fricke, Julia, Scheibenbogen, Carmen, Rabe, Klaus F., Maetzler, Walter, Maetzler, Corina, Laudien, Martin, Frank, Derk, Ballhausen, Sabrina, Hermes, Anne, Miljukov, Olga, Haeusler, Karl Georg, Mokhtari, Nour Eddine El, Witzenrath, Martin, Vehreschild, Jörg Janne, Krefting, Dagmar, Pape, Daniel, Montellano, Felipe A., Kohls, Mirjam, Morbach, Caroline, Störk, Stefan, Reese, Jens-Peter, Keil, Thomas, Heuschmann, Peter, Krawczak, Michael, and Schreiber, Stefan
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- 2022
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18. Prediction of COVID-19 deterioration in high-risk patients at diagnosis: an early warning score for advanced COVID-19 developed by machine learning
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Jakob, Carolin E. M., Mahajan, Ujjwal Mukund, Oswald, Marcus, Stecher, Melanie, Schons, Maximilian, Mayerle, Julia, Rieg, Siegbert, Pletz, Mathias, Merle, Uta, Wille, Kai, Borgmann, Stefan, Spinner, Christoph D., Dolff, Sebastian, Scherer, Clemens, Pilgram, Lisa, Rüthrich, Maria, Hanses, Frank, Hower, Martin, Strauß, Richard, Massberg, Steffen, Er, Ahmet Görkem, Jung, Norma, Vehreschild, Jörg Janne, Stubbe, Hans, Tometten, Lukas, and König, Rainer
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- 2022
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19. Infektionsmanagement in der Hämatologie und Onkologie: Verantwortungsvoller Einsatz von Antiinfektiva
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Classen, Annika Yanina, Sandherr, Michael, Vehreschild, Jörg Janne, and von Lilienfeld-Toal, Marie
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- 2022
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20. Statistical biases due to anonymization evaluated in an open clinical dataset from COVID-19 patients
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Koll, Carolin E. M., Hopff, Sina M., Meurers, Thierry, Lee, Chin Huang, Kohls, Mirjam, Stellbrink, Christoph, Thibeault, Charlotte, Reinke, Lennart, Steinbrecher, Sarah, Schreiber, Stefan, Mitrov, Lazar, Frank, Sandra, Miljukov, Olga, Erber, Johanna, Hellmuth, Johannes C., Reese, Jens-Peter, Steinbeis, Fridolin, Bahmer, Thomas, Hagen, Marina, Meybohm, Patrick, Hansch, Stefan, Vadász, István, Krist, Lilian, Jiru-Hillmann, Steffi, Prasser, Fabian, and Vehreschild, Jörg Janne
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- 2022
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21. Development and validation of BLOOMY prediction scores for 14-day and 6-month mortality in hospitalised adults with bloodstream infections: a multicentre, prospective, cohort study
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Lemke, Elke, Thoma, Norbert, Wolke, Solvy, Imirzalioglu, Can, Herold, Susanne, Tewes, Nicole, Fritzenwanker, Moritz, Vehreschild, Jörg Janne, Classen, Annika Yanina, Tobys, David, Higgins, Paul, Blum, Yannic, Kleipaß, Matthias, Höltig, Lisa, Nagel, Katharina, Schmauder, Kristina, Künstle, Larissa, Stoll, Elisabeth, Dinkelacker, Ariane Gertraud, Peyerl-Hoffmann, Gabriele, Häcker, Georg, Spitznagel, Heike, Olawumi-Hurter, Sara Christina, Tacconelli, Evelina, Göpel, Siri, Gladstone, Beryl P, Eisenbeis, Simone, Hölzl, Florian, Buhl, Michael, Górska, Anna, Cattaneo, Chiara, Mischnik, Alexander, Rieg, Siegbert, Rohde, Anna M, Kohlmorgen, Britta, Falgenhauer, Jane, Trauth, Janina, Käding, Nadja, Kramme, Evelyn, Biehl, Lena M, Walker, Sarah V, Peter, Silke, Gastmeier, Petra, Chakraborty, Trinad, Vehreschild, Maria JGT, Seifert, Harald, Rupp, Jan, and Kern, Winfried V
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- 2022
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22. Trends in Mortality in People With HIV From 1999 through 2020: A Multicohort Collaboration.
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Tusch, Erich, Ryom, Lene, Pelchen-Matthews, Annegret, Mocroft, Amanda, Elbirt, Daniel, Oprea, Cristiana, Günthard, Huldrych F, Staehelin, Cornelia, Zangerle, Robert, Suarez, Isabelle, Vehreschild, Jörg Janne, Wit, Ferdinand, Menozzi, Marianna, Monforte, Antonella d'Arminio, Spagnuolo, Vincenzo, Pradier, Christian, Carlander, Christina, Suanzes, Paula, Wasmuth, Jan-Christian, and Carr, Andrew
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Background Mortality among people with human immunodeficiency virus (HIV) declined with the introduction of combination antiretroviral therapy. We investigated trends in mortality in people with HIV from 1999 through 2020. Methods Data were collected from the Data Collection on Adverse events of Anti-HIV Drugs (D:A:D) cohort between January 1999 through January 2015 and the International Cohort Consortium of Infectious Disease (RESPOND) from October 2017 through December 2020. Age-standardized all-cause and cause-specific mortality rates, classified using Coding Causes of Death in HIV, were calculated. Poisson models were used to assess mortality over time. Results Among 55 716 participants followed for median 6 years (interquartile range, 3–11), 5263 died (mortality rate [MR], 13.7/1000 person-years of follow-up [PYFU]; 95% confidence interval [CI], 13.4–14.1). Changing mortality was observed: AIDS mortality was most common between 1999–2009 (n = 952; MR, 4.2/1000 PYFU; 95% CI, 4.0–4.5) and non-AIDS–defining malignancy (NADM) between 2010–2020 (n = 444; MR, 2.8/1000 PYFU; 95% CI, 2.5–3.1). In multivariable analysis, all-cause mortality declined (adjusted mortality rate ratio [aMRR], 0.97 per year; 95% CI,.96–.98), mostly 1999–2010 (aMRR, 0.96 per year; 95% CI,.95–.97) but was stable 2011–2020 (aMRR, 1.00 per year; 95% CI,.96–1.05). Mortality due to all known causes except NADM also declined. Conclusions Mortality among people with HIV in the D:A:D and/or RESPOND cohorts declined between 1999–2009 and was stable over the period 2010–2020. This decline in mortality was not fully explained by improvements in immunologic–virologic status or other risk factors. [ABSTRACT FROM AUTHOR]
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- 2024
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23. Integration von Bestandsdaten aus Kohorten- und Registerstudien in ein existierendes Forschungsnetzwerk: Nationales Pandemie Kohorten Netz (NAPKON).
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Hofmann, Anna-Lena, Vehreschild, Jörg Janne, Witzenrath, Martin, Hoffmann, Wolfgang, Illig, Thomas, Schreiber, Stefan, Anton, Gabriele, Hellmuth, Johannes Christian, Muenchhoff, Maximilian, Scherer, Clemens, Pley, Christina, Thibeault, Charlotte, Kurth, Florian, Berger, Sarah, Hummel, Michael, Hopff, Sina Marie, Stecher, Melanie, Appel, Katharina, Stahl, Dana, and Kraus, Monika
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- 2024
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24. Machine Learning Based Prediction of COVID-19 Mortality Suggests Repositioning of Anticancer Drug for Treating Severe Cases
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Linden, Thomas, Hanses, Frank, Domingo-Fernández, Daniel, DeLong, Lauren Nicole, Kodamullil, Alpha Tom, Schneider, Jochen, Vehreschild, Maria J.G.T., Lanznaster, Julia, Ruethrich, Maria Madeleine, Borgmann, Stefan, Hower, Martin, Wille, Kai, Feldt, Torsten, Rieg, Siegbert, Hertenstein, Bernd, Wyen, Christoph, Roemmele, Christoph, Vehreschild, Jörg Janne, Jakob, Carolin E.M., Stecher, Melanie, Kuzikov, Maria, Zaliani, Andrea, and Fröhlich, Holger
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- 2021
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25. The protective effect of tumor necrosis factor-alpha inhibitors in COVID-19 in patients with inflammatory rheumatic diseases compared to the general population—A comparison of two German registries
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Hasseli, Rebecca, primary, Hanses, Frank, additional, Stecher, Melanie, additional, Specker, Christof, additional, Weise, Tobias, additional, Borgmann, Stefan, additional, Hasselberger, Martina, additional, Hertenstein, Bernd, additional, Hower, Martin, additional, Hoyer, Bimba F., additional, Koll, Carolin, additional, Krause, Andreas, additional, von Lilienfeld-Toal, Marie, additional, Lorenz, Hanns-Martin, additional, Merle, Uta, additional, Nunes de Miranda, Susana M., additional, Pletz, Mathias W., additional, Regierer, Anne C., additional, Richter, Jutta G., additional, Rieg, Siegbert, additional, Roemmele, Christoph, additional, Ruethrich, Maria M., additional, Schmeiser, Tim, additional, Schulze-Koops, Hendrik, additional, Strangfeld, Anja, additional, Vehreschild, Maria J.G.T., additional, Voit, Florian, additional, Voll, Reinhard E., additional, Vehreschild, Jörg Janne, additional, Müller-Ladner, Ulf, additional, and Pfeil, Alexander, additional
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- 2024
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26. 32/w mit geplanter Induktionstherapie bei neu diagnostizierter akuter lymphatischer Leukämie: Vorbereitung auf die Facharztprüfung: Fall 5
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Classen, Annika Y. and Vehreschild, Jörg Janne
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- 2021
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27. Primary prophylaxis of bacterial infections and Pneumocystis jirovecii pneumonia in patients with hematologic malignancies and solid tumors: 2020 updated guidelines of the Infectious Diseases Working Party of the German Society of Hematology and Medical Oncology (AGIHO/DGHO)
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Classen, Annika Y., Henze, Larissa, von Lilienfeld-Toal, Marie, Maschmeyer, Georg, Sandherr, Michael, Graeff, Luisa Durán, Alakel, Nael, Christopeit, Maximilian, Krause, Stefan W., Mayer, Karin, Neumann, Silke, Cornely, Oliver A., Penack, Olaf, Weißinger, Florian, Wolf, Hans-Heinrich, and Vehreschild, Jörg Janne
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- 2021
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28. Chronic Liver Enzyme Elevation and Use of Contemporary ARVs Among People With HIV
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Roen, Ashley, Peters, Lars, Wandeler, Gilles, Van Der Valk, Marc, Zangerle, Robert, Günthard, Hüldrych Fritz, Wit, Ferdinand, Mussini, Cristina, De Wit, Stéphane, D’Arminio Monforte, Antonella, Vehreschild, Jörg Janne, Castagna, Antonella, Jaschinski, Nadine, Vannappagari, Vani, Chen, Linda, Tallada, Joan, C’mar, John, Mocroft, Amanda, Ryom, Lene, Roen, Ashley, Peters, Lars, Wandeler, Gilles, Van Der Valk, Marc, Zangerle, Robert, Günthard, Hüldrych Fritz, Wit, Ferdinand, Mussini, Cristina, De Wit, Stéphane, D’Arminio Monforte, Antonella, Vehreschild, Jörg Janne, Castagna, Antonella, Jaschinski, Nadine, Vannappagari, Vani, Chen, Linda, Tallada, Joan, C’mar, John, Mocroft, Amanda, and Ryom, Lene
- Abstract
Background. While use of some older antiretroviral drugs (ARVs) is associated with chronic liver enzyme elevation (cLEE), the impact of newer ARVs remains unknown. Methods. People with HIV enrolled in the RESPOND cohort who started an ARV after January 1, 2012 were included (baseline). The primary outcome was first cLEE individuals were censored at first of cLEE, last visit, death, or December 31, 2021. Incidence rates (IRs; events/1000 person-years) were calculated for each ARV overall and by ARV exposure (6–12 months, 1–2 years, and 2+ years). Poisson regression was used to estimate the incidence rate ratio (IRR) of cLEE and its association with individual ARVs and ARV class. Results. Of 17 106 individuals included contributing 87 924 person-years of follow-up, 1932 (11.3%) experienced cLEE (incidence rate [IR], 22.0; 95% CI, 21.0–23.0). There was no evidence of a cumulative ARV effect on cLEE incidence, (6–12 months: IR, 45.8; 95% CI, 41.4–50.19; 1–2 years: IR, 34.3; 95% CI, 31.5–37.4; and 2+ years: IR, 18.5; 95% CI, 17.4–19.7). Any use (vs no prior use) of non-nucleoside reverse transcriptase inhibitors (NNRTIs) as a class and tenofovir disoproxil fumarate (TDF) was independently associated with an increased IRR of cLEE, and any use of darunavir (DRV) was associated with a decreased risk of cLEE. Conclusions. cLEE is common and more frequent during the first year after initiating new ARVs. With a >5-year median follow-up, we found no short-term liver safety concerns with the use of INSTIs. Use of NNRTIs and TDF was associated with an increased cLEE risk, while DRV was associated with lower risk., SCOPUS: ar.j, info:eu-repo/semantics/published
- Published
- 2024
29. Trends in mortality in people with HIV from 1999 to 2020: a multi-cohort collaboration
- Author
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Tusch, E, Ryom, L, Pelchen-Matthews, A, Mocroft, A, Elbirt, D, Oprea, C, Günthard, H, Staehelin, C, Zangerle, R, Suarez, I, Vehreschild, J, Wit, F, Menozzi, M, d'Arminio Monforte, A, Spagnuolo, V, Pradier, C, Carlander, C, Suanzes, P, Wasmuth, J, Carr, A, Petoumenos, K, Borgans, F, Bonnet, F, De Wit, S, El-Sadr, W, Neesgaard, B, Jaschinski, N, Greenberg, L, Hosein, S, Gallant, J, Vannappagari, V, Young, L, Sabin, C, Lundgren, J, Peters, L, Reekie, J, Calvo, G, Dabis, F, Kirk, O, Law, M, Monforte, A, Morfeldt, L, Reiss, P, Weber, R, Lind-Thomsen, A, Brandt, R, Hillebreght, M, Zaheri, S, Scherrer, A, Schöni-Affolter, F, Rickenbach, M, Tavelli, A, Fanti, I, Leleux, O, Mourali, J, Marec, F, Boerg, E, Thulin, E, Sundström, A, Bartsch, G, Thompsen, G, Necsoi, C, Delforge, M, Fontas, E, Caissotti, C, Dollet, K, Mateu, S, Torres, F, Blance, A, Huang, R, Puhr, R, Laut, K, Kristensen, D, Phillips, A, Kamara, D, Smith, C, Hatleberg, C, Raben, D, Matthews, C, Bojesen, A, Grevsen, A, Powderly, B, 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P, Rauch, A, Rudin, C, Speck, R, Stöckle, M, Tarr, P, Trkola, A, Vernazza, P, Wandeler, G, Yerly, S, Valk, M, Hutchinson, J, Rupasinghe, D, Han, W, Appoyer, H, Vera, J, Broster, B, Barbour, L, Carney, D, Greenland, L, Coughlan, R, Saint-Pierre, C, Stephan, C, Bucht, M, Chokoshvili, O, Borghi, V, Casabona, J, Miro, J, Lampe, F, Burns, F, Chaloner, C, Muccini, C, Lolatto, R, Sönnerborg, A, Nowak, P, Vesterbacka, J, Mattsson, L, Carrick, D, Stigsäter, K, Kusejko, K, Schulze, N, Franke, B, Rooney, J, Mcnicholl, I, Garges, H, Campo, R, Volny-Anne, A, Dedes, N, Williams, E, Bruguera, A, Volny-Anne, R, Mendão, L, Timiryasova, A, Fursa, O, Jakobsen, M, Kraef, C, Gardizi, M, Andersen, K, Kumar, L, Elsing, T, Shahi, S, Valdenmaiier, O, Bansi-Matharu, L, Byonanebye, D, Bannister, W, Roen, A, Null, N, Tusch, Erich, Ryom, Lene, Pelchen-Matthews, Annegret, Mocroft, Amanda, Elbirt, Daniel, Oprea, Cristiana, Günthard, Huldrych F, Staehelin, Cornelia, Zangerle, Robert, Suarez, Isabelle, Vehreschild, Jörg Janne, Wit, Ferdinand, Menozzi, Marianna, d'Arminio Monforte, Antonella, Spagnuolo, Vincenzo, Pradier, Christian, Carlander, Christina, Suanzes, Paula, Wasmuth, Jan-Christian, Carr, Andrew, Petoumenos, Kathy, Borgans, Frauke, Bonnet, Fabrice, De Wit, Stephane, El-Sadr, Wafaa, Neesgaard, Bastian, Jaschinski, Nadine, Greenberg, Lauren, Hosein, Sean R, Gallant, Joel, Vannappagari, Vani, Young, Lital, Sabin, Caroline, Lundgren, Jens, Peters, Lars, Reekie, Joanne, Monforte, A d’Arminio, Brandt, R Salbøl, Wit, F W N M, Marec, F Le, Laut, K Grønborg, Sabin, C A, Phillips, A N, Kamara, D A, Smith, C J, Hatleberg, C I, Brandt, R S, Grevsen, A L, Lundgren, J D, Fux, C A, Monforte, A d'Arminio, Iversen, J S, Reiss, Central P, Prins, J M, Kuijpers, T W, Scherpbier, H J, van der Meer, J T M, Godfried, M H, Nellen, F J B, Geerlings, S E, Bos, J C, Wiersinga, W J, Hovius, J W, van Hes, A M H, Nobel, H E, Pijnappel, F J J, Back, N K T, Zaaijer, H L, Cornelissen, M T E, Schinkel, C J, Thomas, X V, Ziekenhuis, Admiraal De Ruyter, de Looff, L Hage, Ziekenhuis, Catharina, Pronk, M J H, Ammerlaan, H S M, De Munnik, E S, Jansz, A R, Wegdam, M C A, Weijsenfeld, A M, van der Ende, M E, De Vries-Sluijs, T E M S, van Gorp, E C M, Schurink, C A M, Nouwen, J L, Rijnders, B J A, Bax, H I, van Beek, J E A, van Zonneveld, L M, van den Berg-Cameron, H J, Bruinsma-Broekman, F B, de Man, M de Zeeuw, Boucher, C A B, Koopmans, M P G, van Kampen, J J A, Pas, S D, MC–Sophia, Erasmus, Driessen, G J A, van Rossum, A M C, van der Knaap, L C, de Ven, C J H M Duijf-van, Ziekenhuis, Haga, Schippers, E F, van IJperen, J M, Franck, P F H, Elsenburg, L J M, Kwa, I S, Groeneveld, P H P, Bouwhuis, J W, van den Berg, J F, van Hulzen, A G W, van der Bliek, G L, Bor, P C J, Wolfhagen, M J H M, Ruijs, G J H M, Kroon, F P, de Boer, M G J, Bauer, M P, Vollaard, A M, Claas, E C J, den Hollander, J G, Smit, J V, Lowe, S H, Lashof, A M L Oude, Ackens, R P, van Loo, I H M, Havenith, T R A, Leyten, E M S, Gelinck, L B S, Wildenbeest, G S, Mutsaers, J A E M, Jansen, C L, Mulder, J W, Vrouenraets, S M E, Lauw, F N, van Broekhuizen, M C, Vlasblom, D J, Smits, P H M, Zuiderzee, M C, Bosma, A S, van Vonderen, M G A, van Houte, D P F, Kampschreur, L M, Kootstra, G J, Delsing, C E, Stuart, J W T Cohen, Diederen, B M W, van Truijen-Oud, F A, van der Reijden, W A, van den Berk, G E L, Blok, W L, Frissen, P H J, Lettinga, K D, Schouten, W E M, Brouwer, C J, Geerders, G F, Kleene, M J, van der Meché, I B, Toonen, A J M, Koopmans, P P, van der Ven, A J A M, ter Hofstede, H J M, Dofferhoff, A S M, Bosch, M E W, Grintjes-Huisman, K J T, Zomer, B J, Stelma, F F, Gisolf, E H, Hassing, R J, van Bentum, P H M, Swanink, C M A, van Lelyveld, S F L, van der Prijt, L M M, Herpers, B L, Verhagen, D W M, Ziekenhuis, St Elisabeth, van Kasteren, M E E, Brouwer, A E, de Wiel, B A F M de Kruijf-van, Santegoets, R M W J, Marcelis, J H, Buiting, A G M, Kabel, P J, Bierman, W F W, Wilting, K R, Jonge, H de Groot-de, van der Meulen, P A, de Weerd, D A, Niesters, H G M, van Leer-Buter, C C, Hoepelman, A I M, Ellerbroek, P M, Oosterheert, J J, Arends, J E, Barth, R E, Wassenberg, M W M, Schadd, E M, van Elst-Laurijssen, D H M, van Oers-Hazelzet, E E B, Wensing, A M J, Peters, E J G, van Agtmael, M A, Laan, L M, Pettersson, A M, Vandenbroucke-Grauls, C M J E, Ang, C W, Kinderziekenhuis, Wilhelmina, Geelen, S P M, Wolfs, T F W, Bont, L J, Bezemer, D O, van Sighem, A I, Boender, T S, Rademaker, M J, Pellegrin, J L, Vareil, M O, Dauchy, F A, Receveur, M C, Vandenhende, M A, Viallard, J F, Lafon, Me, Blaizeau, M J, Boerg, Eloïse, Law, Central M, Calvo, Central G, Sambeat, M A, Gennotte, A F, Payen, M C, Neaton, Central J, El-Sadr, W M, Abrams, D I, Crane, L R, Fischer, A H, Larsen, J F, Wien, Pulmologisches Zentrum der Stadt, Mitsura, V M, Møller, N F, Nielsen, L N, Smidt, Jelena, Siseklinik, Nakkusosakond, Viard, J-P, Stellbrink, H J, Goethe, J W, Sthoeger, Z M, Monforte, A D’Arminio, Annunziata, Ospedale S Maria, Blokhina, I N, Novogrod, Nizhny, Gatell, J M, Miró, J M, Rodriguez, J M, Laporte, J M, Johnson, A M, Johnson, M A, Morfeldt, Central L, Perri, G Di, Marchetti, G C, Perno, C F, Caputo, S Lo, Capobianchi, M R, Biagio, A Di, Roldan, E Quiros, Santoro, M M, Caro, A Di, Manconi, P E, Moioli, M C, Ridolfo, A L, Martino, F Di, Cattelan, A M, Ursitti, M A, Sulekova, L Fontanelli, Plazzi, M M, Del Vecchio, R Fontana, Giuli, C Di, Orofino, G C, Roger, P M, Braun, D L, Bucher, H C, Günthard, H F, Hirsch, H H, Kouyos, R D, de Tejada, B Martinez, Metzner, K J, Scherrer, A U, Valk, Marc vd, Han, W Min, Saint-Pierre, C H U, Miro, J M, Wasmuth, J C, Vehreschild, J J, McNicholl, I, Williams, E D, Volny-Anne, R Campo Alain, Dedes, Nikos, Mendão, Luis, Jakobsen, M L, Kumar, L Ramesh, Elsing, T W, and null, null
- Abstract
Background: Mortality among people with HIV declined with the introduction of combination antiretroviral therapy. We investigated trends over time in all-cause and cause-specific mortality in people with HIV from 1999-2020. Methods: Data were collected from the D:A:D cohort from 1999 through January 2015 and RESPOND from October 2017 through 2020. Age-standardized all-cause and cause-specific mortality rates, classified using Coding Causes of Death in HIV (CoDe), were calculated. Poisson regression models were used to assess mortality trends over time. Results: Among 55716 participants followed for a median of 6 years (IQR 3-11), 5263 participants died (crude mortality rate [MR] 13.7/1000 PYFU; 95%CI 13.4-14.1). Changing patterns of mortality were observed with AIDS as the most common cause of death between 1999- 2009 (n = 952, MR 4.2/1000 PYFU; 95%CI 4.0-4.5) and non-AIDS defining malignancy (NADM) from 2010 -2020 (n = 444, MR 2.8/1000 PYFU; 95%CI 2.5-3.1). In multivariable analysis, all-cause mortality declined over time (adjusted mortality rate ratio [aMRR] 0.97 per year; 95%CI 0.96, 0.98), mostly from 1999 through 2010 (aMRR 0.96 per year; 95%CI 0.95-0.97), and with no decline shown from 2011 through 2020 (aMRR 1·00 per year; 95%CI 0·96-1·05). Mortality due all known causes except NADM also declined over the entire follow-up period. Conclusion: Mortality among people with HIV in the D:A:D and/or RESPOND cohorts decreased between 1999 and 2009 and was stable over the period from 2010 through 2020. The decline in mortality rates was not fully explained by improvements in immunologic-virologic status or other risk factors.
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- 2024
30. Chronic Liver Enzyme Elevation and Use of Contemporary ARVs Among People With HIV.
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Roen, Ashley O, Peters, Lars, Wandeler, Gilles, van der Valk, Marc, Zangerle, Robert, Günthard, Huldrych F, Wit, Ferdinand, Mussini, Cristina, Wit, Stéphane De, Monforte, Antonella d'Arminio, Vehreschild, Jörg Janne, Castagna, Antonella, Jaschinski, Nadine, Vannappagari, Vani, Chen, Linda, Tallada, Joan, C'mar, John, Mocroft, Amanda, and Ryom, Lene
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LIVER enzymes ,HIV-positive persons ,NON-nucleoside reverse transcriptase inhibitors ,POISSON regression ,ANTIRETROVIRAL agents - Abstract
Background While use of some older antiretroviral drugs (ARVs) is associated with chronic liver enzyme elevation (cLEE), the impact of newer ARVs remains unknown. Methods People with HIV enrolled in the RESPOND cohort who started an ARV after January 1, 2012 were included (baseline). The primary outcome was first cLEE individuals were censored at first of cLEE, last visit, death, or December 31, 2021. Incidence rates (IRs; events/1000 person-years) were calculated for each ARV overall and by ARV exposure (6–12 months, 1–2 years, and 2+ years). Poisson regression was used to estimate the incidence rate ratio (IRR) of cLEE and its association with individual ARVs and ARV class. Results Of 17 106 individuals included contributing 87 924 person-years of follow-up, 1932 (11.3%) experienced cLEE (incidence rate [IR], 22.0; 95% CI, 21.0–23.0). There was no evidence of a cumulative ARV effect on cLEE incidence, (6–12 months: IR, 45.8; 95% CI, 41.4–50.19; 1–2 years: IR, 34.3; 95% CI, 31.5–37.4; and 2+ years: IR, 18.5; 95% CI, 17.4–19.7). Any use (vs no prior use) of non-nucleoside reverse transcriptase inhibitors (NNRTIs) as a class and tenofovir disoproxil fumarate (TDF) was independently associated with an increased IRR of cLEE, and any use of darunavir (DRV) was associated with a decreased risk of cLEE. Conclusions cLEE is common and more frequent during the first year after initiating new ARVs. With a >5-year median follow-up, we found no short-term liver safety concerns with the use of INSTIs. Use of NNRTIs and TDF was associated with an increased cLEE risk, while DRV was associated with lower risk. [ABSTRACT FROM AUTHOR]
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- 2024
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31. First results of the “Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS)”
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Jakob, Carolin E. M., Borgmann, Stefan, Duygu, Fazilet, Behrends, Uta, Hower, Martin, Merle, Uta, Friedrichs, Anette, Tometten, Lukas, Hanses, Frank, Jung, Norma, Rieg, Siegbert, Wille, Kai, Grüner, Beate, Klinker, Hartwig, Gersbacher-Runge, Nicole, Hellwig, Kerstin, Eberwein, Lukas, Dolff, Sebastian, Rauschning, Dominic, von Bergwelt-Baildon, Michael, Lanznaster, Julia, Strauß, Richard, Trauth, Janina, de With, Katja, Ruethrich, Maria, Lueck, Catherina, Nattermann, Jacob, Tscharntke, Lene, Pilgram, Lisa, Fuhrmann, Sandra, Classen, Annika, Stecher, Melanie, Schons, Maximilian, Spinner, Christoph, and Vehreschild, Jörg Janne
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- 2021
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32. Invasive aspergillosis in solid organ transplant patients: diagnosis, prophylaxis, treatment, and assessment of response
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Neofytos, Dionysios, Garcia-Vidal, Carolina, Lamoth, Frédéric, Lichtenstern, Christoph, Perrella, Alessandro, and Vehreschild, Jörg Janne
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- 2021
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33. Evaluation of body-surface-area adjusted dosing of high-dose methotrexate by population pharmacokinetics in a large cohort of cancer patients
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Arshad, Usman, Taubert, Max, Seeger-Nukpezah, Tamina, Ullah, Sami, Spindeldreier, Kirsten C., Jaehde, Ulrich, Hallek, Michael, Fuhr, Uwe, Vehreschild, Jörg Janne, and Jakob, Carolin
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- 2021
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34. Clostridioides difficile infection (CDI): A pan-European multi-center cost and resource utilization study, results from the Combatting Bacterial Resistance in Europe CDI (COMBACTE-CDI)
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Academic Partners, Bonten, Marc, Davies, Kerrie A., Wilcox, Mark H., Kuijper, Ed, Rupnik, Maja, Wingen-Heimann, Sebastian, Tacconelli, Evelina, Vilken, Tuba, Petrosillo, Nicola, EFPIA Partners, Pfizer Ltd, GlaxoSmithKline, bioMérieux, Pasteur, Sanofi, Da Volterra, The Management Board of COMBACTE-CDI, Cleuziat, Philippe, Webber, Chris, Wingen-Heimann, Sebastian M., Davies, Kerrie, Viprey, Virginie F., Davis, Georgina, Vehreschild, Maria J.G.T., Lurienne, Lise, Bandinelli, Pierre-Alain, Cornely, Oliver A., Hopff, Sina M., and Vehreschild, Jörg Janne
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- 2023
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35. Infektionen bei Immunschwäche
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Claßen, Annika Y., primary, Cornely, Oliver A., additional, Hanses, Frank, additional, Köhler, Philipp, additional, Mellinghoff, Sibylle, additional, Vehreschild, Jörg Janne, additional, and Witzke, Oliver, additional
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- 2021
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36. Intravenous and tablet formulation of posaconazole in antifungal therapy and prophylaxis: A retrospective, non-interventional, multicenter analysis of hematological patients treated in tertiary-care hospitals
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Heimann, Sebastian M., Penack, Olaf, Heinz, Werner J., Rachow, Tobias, Egerer, Gerlinde, Kessel, Johanna, Claßen, Annika Y., and Vehreschild, Jörg Janne
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- 2019
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37. Measures of Longitudinal Immune Dysfunction and Risk of AIDS and Non-AIDS Defining Malignancies in Antiretroviral-Treated People With Human Immunodeficiency Virus.
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Chammartin, Frédérique, Mocroft, Amanda, Egle, Alexander, Zangerle, Robert, Smith, Colette, Mussini, Cristina, Wit, Ferdinand, Vehreschild, Jörg Janne, Monforte, Antonella d'Arminio, Castagna, Antonella, Bailly, Laurent, Bogner, Johannes, Wit, Stéphane de, Matulionyte, Raimonda, Law, Matthew, Svedhem, Veronica, Tallada, Joan, Garges, Harmony P, Marongiu, Andrea, and Borges, Álvaro H
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RISK assessment ,ANTIRETROVIRAL agents ,T cells ,VIRAL load ,RESEARCH funding ,CD4 lymphocyte count ,SCIENTIFIC observation ,HIV infections ,DESCRIPTIVE statistics ,PSYCHOLOGY of HIV-positive persons ,TUMORS ,CONFIDENCE intervals ,AIDS ,PROPORTIONAL hazards models ,DISEASE complications - Abstract
Background Human immunodeficiency virus (HIV) infection leads to chronic immune activation/inflammation that can persist in virally suppressed persons on fully active antiretroviral therapy (ART) and increase risk of malignancies. The prognostic role of low CD4:CD8 ratio and elevated CD8 cell counts on the risk of cancer remains unclear. Methods We investigated the association of CD4:CD8 ratio on the hazard of non-AIDS defining malignancy (NADM), AIDS-defining malignancy (ADM) and most frequent group of cancers in ART-treated people with HIV (PWH) with a CD4 and CD8 cell counts and viral load measurements at baseline. We developed Cox proportional hazard models with adjustment for known confounders of cancer risk and time-dependent cumulative and lagged exposures of CD4:CD8 ratio to account for time-evolving risk factors and avoid reverse causality. Results CD4:CD8 ratios below 0.5, compared to above 1.0, were independently associated with a 12-month time-lagged higher risk of ADM and infection-related malignancies (adjusted hazard ratio 2.61 [95% confidence interval {CI }1.10–6.19] and 2.03 [95% CI 1.24–3.33], respectively). CD4 cell counts below 350 cells/μL were associated with an increased risk of NADMs and ADMs, as did infection, smoking, and body mass index-related malignancies. Conclusions In ART-treated PWH low CD4:CD8 ratios were associated with ADM and infection-related cancers independently from CD4 and CD8 cell counts and may alert clinicians for cancer screening and prevention of NADM. [ABSTRACT FROM AUTHOR]
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- 2024
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38. Quality, availability and suitability of antimicrobial stewardship guidance: a multinational qualitative study.
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Linde-Ozola, Zane, Classen, Annika Y, Giske, Christian G, Göpel, Siri, Eliakim-Raz, Noa, Semret, Makeda, Simonsen, Gunnar Skov, Vehreschild, Jörg Janne, Jørgensen, Silje Bakken, Kessel, Johanna, Kleppe, Lars Kåre Selland, Oma, Dorthea Hagen, Vehreschild, Maria J G T, Vilde, Aija, Dumpis, Uga, and group, PILGRIM study
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- 2024
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39. COVID-19 in Patients with Active Cancer: Higher Inflammatory Activity Predicts Poor Outcome.
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Rüthrich, Maria Madeleine, Khodamoradi, Yascha, Lanznaster, Julia, Stecher, Melanie, Tometten, Lukas, Voit, Florian, Koll, Carolin E.M., Borgmann, Stefan, Vehreschild, Jörg Janne, Ole Jensen, Björn-Erik, Hanses, Frank, Giessen-Jung, Clemens, Wille, Kai, von Lilienfeld-Toal, Marie, and Beutel, Gernot
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COVID-19 ,CANCER patients ,MORTALITY risk factors ,DEATH rate ,REGRESSION analysis - Abstract
Introduction: Active malignancies have been identified as an independent risk factor for severity and mortality in COVID-19. However, direct comparisons between SARS-CoV-2-infected patients with active (acP) and non-active cancers (n-acP) remain scarce. Patients and Methods: We retrospectively analyzed a cohort of cancer patients with PCR-confirmed SARS-CoV-2 infection, enrolled from March 16, 2020, to July 31, 2021. Data on demographics, cancer, and laboratory findings were collected. Descriptive and subsequent regression analyses were performed. Endpoints were "deterioration to severe COVID-19" and "infection-associated mortality." Results: In total, 987 cancer patients (510 acP vs. 477 n-acP) were included in our analysis. The majority was >55 years old, more men than women were included. At detection of SARS-CoV-2, 65.5% of patients had mild/moderate symptoms, while deterioration to severe COVID-19 was slightly more common in acP (19 vs. 16%; p = 0.284). COVID-19-associated mortality was significantly higher in acP (24 vs. 17.5%, p < 0.001). In terms of laboratory tests, severe cytopenia and elevated levels of inflammatory markers were common findings in acP at baseline, particularly in those who developed a severe infection or died. Multivariate analysis revealed that ferritin (HR 14.24 [2.1–96], p = 0.006) and CRP (HR 2.85 [1.02–8.02], p = 0.046) were associated with severity and mortality. In n-acP, association was seen for ferritin only (HR 4.1 [1.51–11.17], p = 0.006). Conclusion: Comparing patients with active and non-active cancer, the former showed higher mortality rates. Also, inflammatory markers were significantly increased, assuming higher levels of inflammation may play a role in the adverse outcome of COVID-19 in aCP. [ABSTRACT FROM AUTHOR]
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- 2024
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40. COVID-19 in patients with active - higher inflammatory activity predicts poor outcome.
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Rüthrich, Maria Madeleine, primary, Khodamoradi, Yascha, additional, Lanznaster, Julia, additional, Stecher, Melanie, additional, Tometten, Lukas, additional, Voit, Florian, additional, Koll, Carolin E.M., additional, Borgmann, Stefan, additional, Vehreschild, Jörg Janne, additional, Ole Jensen, Björn-Erik, additional, Hanses, Frank, additional, Giessen-Jung, Clemens, additional, Wille, Kai, additional, von Lilienfeld-Toal, Marie, additional, and Beutel, Gernot, additional
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- 2023
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41. Chlorhexidine-containing dressings in the prevention of central venous catheter-related bloodstream infections: A cost and resource utilization analysis
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Heimann, Sebastian M., Biehl, Lena M., Vehreschild, Jörg Janne, Franke, Bernd, Cornely, Oliver A., and Vehreschild, Maria J.G.T.
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- 2018
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42. Antiretroviral treatment indications and adherence to the German-Austrian treatment initiation guidelines in the German ClinSurv HIV Cohort between 1999 and 2016
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Stecher, Melanie, Schommers, Philipp, Schmidt, Daniel, Kollan, Christian, Gunsenheimer-Bartmeyer, Barbara, Lehmann, Clara, Platten, Martin, Fätkenheuer, Gerd, Vehreschild, Jörg Janne, and ClinSurv Study Group
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- 2019
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43. Design and evaluation of a data anonymization pipeline to promote Open Science on COVID-19
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Jakob, Carolin E. M., Kohlmayer, Florian, Meurers, Thierry, Vehreschild, Jörg Janne, and Prasser, Fabian
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- 2020
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44. Concepts of lines of therapy in cancer treatment: Findings from an expert interview-based study
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Falchetto, Lisa, primary, Bender, Bernd, additional, Erhard, Ian, additional, Zeiner, Kim N., additional, Stratmann, Jan A., additional, Koll, Florestan J., additional, Wagner, Sebastian, additional, Reiser, Marcel, additional, Gasimli, Khayal, additional, Stehle, Angelika, additional, Voss, Martin, additional, Ballo, Olivier, additional, Vehreschild, Jörg Janne, additional, and Maier, Daniel, additional
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- 2023
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45. Interoperable, Domain-Specific Extensions for the German Corona Consensus (GECCO) COVID-19 Research Data Set Using an Interdisciplinary, Consensus-Based Workflow: Data Set Development Study
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Lichtner, Gregor, primary, Haese, Thomas, additional, Brose, Sally, additional, Röhrig, Larissa, additional, Lysyakova, Liudmila, additional, Rudolph, Stefanie, additional, Uebe, Maria, additional, Sass, Julian, additional, Bartschke, Alexander, additional, Hillus, David, additional, Kurth, Florian, additional, Sander, Leif Erik, additional, Eckart, Falk, additional, Toepfner, Nicole, additional, Berner, Reinhard, additional, Frey, Anna, additional, Dörr, Marcus, additional, Vehreschild, Jörg Janne, additional, von Kalle, Christof, additional, and Thun, Sylvia, additional
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- 2023
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46. Duration of Protection From Pneumonia After Pneumococcal Vaccination in Hemodialysis Patients (DOPPIO): Protocol for a Prospective Multicenter Study
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Mellinghoff, Sibylle, primary, von Gersdorff, Gero, additional, Bruns, Caroline, additional, Albus, Kerstin, additional, Dimitriou, Vassiliki, additional, Steinbach, Angela, additional, Schaller, Mathias, additional, Vehreschild, Jörg Janne, additional, Cornely, Oliver A, additional, and Liss, Blasius Janusch, additional
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- 2023
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47. Increased circulating fibronectin, depletion of natural IgM and heightened EBV, HSV-1 reactivation in ME/CFS and long COVID
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Liu, Zheng, primary, Hollmann, Claudia, additional, Kalanidhi, Sharada, additional, Grothey, Arnhild, additional, Keating, Sam, additional, Mena-Palomo, Irene, additional, Lamer, Stephanie, additional, Schlosser, Andreas, additional, Kaiping, Agnes, additional, Scheller, Carsten, additional, Sotzny, Franzeska, additional, Horn, Anna, additional, Nürnberger, Carolin, additional, Cejka, Vladimir, additional, Afshar, Boshra, additional, Bahmer, Thomas, additional, Schreiber, Stefan, additional, Vehreschild, Jörg Janne, additional, Miljukov, Olga, additional, Schäfer, Christian, additional, Kretzler, Luzie, additional, Keil, Thomas, additional, Reese, Jens-Peter, additional, Eichner, Felizitas A, additional, Schmidbauer, Lena, additional, Heuschmann, Peter U, additional, Störk, Stefan, additional, Morbach, Caroline, additional, Riemekasten, Gabriela, additional, Beyersdorf, Niklas, additional, Scheibenbogen, Carmen, additional, Naviaux, Robert K, additional, Williams, Marshall, additional, Ariza, Maria E, additional, and Prusty, Bhupesh K, additional
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- 2023
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48. HEnRY: a DZIF LIMS tool for the collection and documentation of biomaterials in multicentre studies
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Heinen, Stephanie, Schulze, Nick, Franke, Bernd, Klein, Florian, Lehmann, Clara, Vehreschild, Maria J. G. T., Gloistein, Claas, Stecher, Melanie, and Vehreschild, Jörg Janne
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- 2020
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49. Clostridioides difficile infection (CDI): A pan-European multi-center cost and resource utilization study, results from the Combatting Bacterial Resistance in Europe CDI (COMBACTE-CDI)
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Epi Infectieziekten, Infection & Immunity, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, JC onderzoeksprogramma Infectious Diseases, Wingen-Heimann, Sebastian M., Davies, Kerrie, Viprey, Virginie F., Davis, Georgina, Wilcox, Mark H., Vehreschild, Maria J.G.T., Lurienne, Lise, Bandinelli, Pierre Alain, Cornely, Oliver A., Vilken, Tuba, Hopff, Sina M., Vehreschild, Jörg Janne, Bonten, Marc, COMBACTE-CDI consortium, Epi Infectieziekten, Infection & Immunity, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, JC onderzoeksprogramma Infectious Diseases, Wingen-Heimann, Sebastian M., Davies, Kerrie, Viprey, Virginie F., Davis, Georgina, Wilcox, Mark H., Vehreschild, Maria J.G.T., Lurienne, Lise, Bandinelli, Pierre Alain, Cornely, Oliver A., Vilken, Tuba, Hopff, Sina M., Vehreschild, Jörg Janne, Bonten, Marc, and COMBACTE-CDI consortium
- Published
- 2023
50. Development of interoperable, domain-specific extensions for the German Corona Consensus (GECCO) COVID-19 research dataset using an interdisciplinary, consensus-based workflow
- Author
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Lichtner, Gregor, Haese, Thomas, Brose, Sally, Röhrig, Larissa, Lysyakova, Liudmila, Rudolph, Stefanie, Uebe, Maria, Sass, Julian, Bartschke, Alexander, Hillus, David, Kurth, Florian Michael, Sander, Leif Erik, Eckart, Falk Christian, Töpfner, Nicole Marina, Berner, Reinhard, Frey, Anna, Dörr, Marcus, Vehreschild, Jörg Janne, Kalle, Christof von, Thun, Sylvia, Lichtner, Gregor, Haese, Thomas, Brose, Sally, Röhrig, Larissa, Lysyakova, Liudmila, Rudolph, Stefanie, Uebe, Maria, Sass, Julian, Bartschke, Alexander, Hillus, David, Kurth, Florian Michael, Sander, Leif Erik, Eckart, Falk Christian, Töpfner, Nicole Marina, Berner, Reinhard, Frey, Anna, Dörr, Marcus, Vehreschild, Jörg Janne, Kalle, Christof von, and Thun, Sylvia
- Abstract
Background: The COVID-19 pandemic has spurred large-scale, inter-institutional research efforts. To enable these efforts, the German Corona Consensus (GECCO) dataset has been developed previously as a harmonized, interoperable collection of the most relevant data elements for COVID-19-related patient research. As GECCO has been developed as a compact core dataset across all medical fields, the focused research within particular medical domains demanded the definition of extension modules that include those data elements that are most relevant to the research performed in these individual medical specialties. Main body: We created GECCO extension modules for the immunization, pediatrics, and cardiology domains with respect to the pandemic requests. The data elements included in each of these modules were selected in a consensus-based process by working groups of medical experts from the respective specialty to ensure that the contents are aligned with the research needs of the specialty. The selected data elements were mapped to international standardized vocabularies and data exchange specifications were created using HL7 FHIR profiles on the appropriate resources. All steps were performed in close interdisciplinary collaboration between medical domain experts, medical information scientists and FHIR developers. The profiles and vocabulary mappings were syntactically and semantically validated in a two-stage process. In that way, we defined dataset specifications for a total number of 23 (immunization), 59 (pediatrics), and 50 (cardiology) data elements that augment the GECCO core dataset. We created and published implementation guides and example implementations as well as dataset annotations for each extension module. Conclusions: We here present extension modules for the GECCO core dataset that contain data elements most relevant to COVID-19-related patient research in immunization, pediatrics and cardiology. These extension modules were defined in an interdiscip
- Published
- 2023
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