Search

Your search keyword '"Veer, I.M."' showing total 44 results
Start Over Author "Veer, I.M."
44 results on '"Veer, I.M."'

2. Dynamic modelling of mental resilience in young adults: Protocol for a longitudinal observational study (DynaM-OBS)

Author

Wackerhagen, C., Veer, I.M., Leeuwen, J.M.C. van, Reppmann, Z.C., Riepenhausen, A., Bögemann, S.A., Mor, N., Puhlmann, L.M.C., Uscilko, A., Zerban, M., Mituniewicz, J., Lerner, A., Yuen, K.S.L., Köber, G., Marciniak, M.A., Pooseh, S., Weermeijer, J.D.M., Arias Vasquez, A., Binder, H., Raedt, W. de, Kleim, B., Myin-Germeys, I., Roelofs, K., Timmer, J., Tüscher, O., Hendler, T., Kobylinska, D., Hermans, E.J., Kalisch, R., and Walter, H.

Subjects
Experimental Psychopathology and Treatment, 230 Affective Neuroscience
Abstract

Contains fulltext : 294461.pdf (Publisher’s version ) (Open Access) Background: Stress-related mental disorders are highly prevalent and pose a substantial burden on individuals and society. Improving strategies for the prevention and treatment of mental disorders requires a better understanding of their risk and resilience factors. This multicenter study aims to contribute to this endeavor by investigating psychological resilience in healthy but susceptible young adults over 9 months. Resilience is conceptualized in this study as the maintenance of mental health or quick recovery from mental health perturbations upon exposure to stressors, assessed longitudinally via frequent monitoring of stressors and mental health. Objective: This study aims to investigate the factors predicting mental resilience and adaptive processes and mechanisms contributing to mental resilience and to provide a methodological and evidence-based framework for later intervention studies. Methods: In a multicenter setting, across 5 research sites, a sample with a total target size of 250 young male and female adults was assessed longitudinally over 9 months. Participants were included if they reported at least 3 past stressful life events and an elevated level of (internalizing) mental health problems but were not presently affected by any mental disorder other than mild depression. At baseline, sociodemographic, psychological, neuropsychological, structural, and functional brain imaging; salivary cortisol and α-amylase levels; and cardiovascular data were acquired. In a 6-month longitudinal phase 1, stressor exposure, mental health problems, and perceived positive appraisal were monitored biweekly in a web-based environment, while ecological momentary assessments and ecological physiological assessments took place once per month for 1 week, using mobile phones and wristbands. In a subsequent 3-month longitudinal phase 2, web-based monitoring was reduced to once a month, and psychological resilience and risk factors were assessed again at the end of the 9-month period. In addition, samples for genetic, epigenetic, and microbiome analyses were collected at baseline and at months 3 and 6. As an approximation of resilience, an individual stressor reactivity score will be calculated. Using regularized regression methods, network modeling, ordinary differential equations, landmarking methods, and neural net–based methods for imputation and dimension reduction, we will identify the predictors and mechanisms of stressor reactivity and thus be able to identify resilience factors and mechanisms that facilitate adaptation to stressors. Results: Participant inclusion began in October 2020, and data acquisition was completed in June 2022. A total of 249 participants were assessed at baseline, 209 finished longitudinal phase 1, and 153 finished longitudinal phase 2. Conclusions: The Dynamic Modelling of Resilience–Observational Study provides a methodological framework and data set to identify predictors and mechanisms of mental resilience, which are intended to serve as an empirical foundation for future intervention studies. International Registered Report Identifier (IRRID): DERR1-10.2196/39817 23 p.

Published
2023

3. Investigating two mobile just-in-time adaptive interventions to foster psychological resilience: Research protocol of the DynaM-INT study

Author

Bögemann, S.A., Riepenhausen, A., Puhlmann, L.M.C., Bar, S., Hermsen, E.J.C., Mituniewicz, J., Reppmann, Z.C., Uściƚko, A., Leeuwen, J.M.C. van, Wackerhagen, C., Yuen, K.S.L., Zerban, M., Weermeijer, J., Marciniak, M.A., Mor, N., Kraaij, A. van, Kober, G., Pooseh, S., Koval, P., Arias Vasquez, A., Binder, H., Raedt, W. de, Kleim, B., Myin-Germeys, I., Roelofs, K., Timmer, J., Tüscher, O., Hendler, T., Kobylinska, D., Veer, I.M., Kalisch, R., Hermans, E.J., Walter, H., Bögemann, S.A., Riepenhausen, A., Puhlmann, L.M.C., Bar, S., Hermsen, E.J.C., Mituniewicz, J., Reppmann, Z.C., Uściƚko, A., Leeuwen, J.M.C. van, Wackerhagen, C., Yuen, K.S.L., Zerban, M., Weermeijer, J., Marciniak, M.A., Mor, N., Kraaij, A. van, Kober, G., Pooseh, S., Koval, P., Arias Vasquez, A., Binder, H., Raedt, W. de, Kleim, B., Myin-Germeys, I., Roelofs, K., Timmer, J., Tüscher, O., Hendler, T., Kobylinska, D., Veer, I.M., Kalisch, R., Hermans, E.J., and Walter, H.

Abstract

Contains fulltext : 295904.pdf (Publisher’s version ) (Open Access), BACKGROUND: Stress-related disorders such as anxiety and depression are highly prevalent and cause a tremendous burden for affected individuals and society. In order to improve prevention strategies, knowledge regarding resilience mechanisms and ways to boost them is highly needed. In the Dynamic Modelling of Resilience - interventional multicenter study (DynaM-INT), we will conduct a large-scale feasibility and preliminary efficacy test for two mobile- and wearable-based just-in-time adaptive interventions (JITAIs), designed to target putative resilience mechanisms. Deep participant phenotyping at baseline serves to identify individual predictors for intervention success in terms of target engagement and stress resilience. METHODS: DynaM-INT aims to recruit N = 250 healthy but vulnerable young adults in the transition phase between adolescence and adulthood (18-27 years) across five research sites (Berlin, Mainz, Nijmegen, Tel Aviv, and Warsaw). Participants are included if they report at least three negative burdensome past life events and show increased levels of internalizing symptoms while not being affected by any major mental disorder. Participants are characterized in a multimodal baseline phase, which includes neuropsychological tests, neuroimaging, bio-samples, sociodemographic and psychological questionnaires, a video-recorded interview, as well as ecological momentary assessments (EMA) and ecological physiological assessments (EPA). Subsequently, participants are randomly assigned to one of two ecological momentary interventions (EMIs), targeting either positive cognitive reappraisal or reward sensitivity. During the following intervention phase, participants' stress responses are tracked using EMA and EPA, and JITAIs are triggered if an individually calibrated stress threshold is crossed. In a three-month-long follow-up phase, parts of the baseline characterization phase are repeated. Throughout the entire study, stressor exposure and mental health are

Published
2023

4. Psychological Resilience Factors and Their Association With Weekly Stressor Reactivity During the COVID-19 Outbreak in Europe: Prospective Longitudinal Study.

Author

Bögemann, S.A., Puhlmann, L.M.C., Wackerhagen, C., Zerban, M., Riepenhausen, A., Köber, G., Yuen, K.S.L., Pooseh, S., Marciniak, M.A., Reppmann, Z.C., Uściƚko, A., Weermeijer, J.D.M., Lenferink, D.B., Mituniewicz, J., Robak, N., Donner, N.C., Mestdagh, M., Verdonck, S., Dick, R. van, Kleim, B., Lieb, K., Leeuwen, J.M.C. van, Kobylińska, D., Myin-Germeys, I., Walter, H., Tüscher, O., Hermans, E.J., Veer, I.M., Kalisch, R., Bögemann, S.A., Puhlmann, L.M.C., Wackerhagen, C., Zerban, M., Riepenhausen, A., Köber, G., Yuen, K.S.L., Pooseh, S., Marciniak, M.A., Reppmann, Z.C., Uściƚko, A., Weermeijer, J.D.M., Lenferink, D.B., Mituniewicz, J., Robak, N., Donner, N.C., Mestdagh, M., Verdonck, S., Dick, R. van, Kleim, B., Lieb, K., Leeuwen, J.M.C. van, Kobylińska, D., Myin-Germeys, I., Walter, H., Tüscher, O., Hermans, E.J., Veer, I.M., and Kalisch, R.

Abstract

Item does not contain fulltext, BACKGROUND: Cross-sectional relationships between psychosocial resilience factors (RFs) and resilience, operationalized as the outcome of low mental health reactivity to stressor exposure (low "stressor reactivity" [SR]), were reported during the first wave of the COVID-19 pandemic in 2020. OBJECTIVE: Extending these findings, we here examined prospective relationships and weekly dynamics between the same RFs and SR in a longitudinal sample during the aftermath of the first wave in several European countries. METHODS: Over 5 weeks of app-based assessments, participants reported weekly stressor exposure, mental health problems, RFs, and demographic data in 1 of 6 different languages. As (partly) preregistered, hypotheses were tested cross-sectionally at baseline (N=558), and longitudinally (n=200), using mixed effects models and mediation analyses. RESULTS: RFs at baseline, including positive appraisal style (PAS), optimism (OPT), general self-efficacy (GSE), perceived good stress recovery (REC), and perceived social support (PSS), were negatively associated with SR scores, not only cross-sectionally (baseline SR scores; all P<.001) but also prospectively (average SR scores across subsequent weeks; positive appraisal (PA), P=.008; OPT, P<.001; GSE, P=.01; REC, P<.001; and PSS, P=.002). In both associations, PAS mediated the effects of PSS on SR (cross-sectionally: 95% CI -0.064 to -0.013; prospectively: 95% CI -0.074 to -0.0008). In the analyses of weekly RF-SR dynamics, the RFs PA of stressors generally and specifically related to the COVID-19 pandemic, and GSE were negatively associated with SR in a contemporaneous fashion (PA, P<.001; PAC,P=.03; and GSE, P<.001), but not in a lagged fashion (PA, P=.36; PAC, P=.52; and GSE, P=.06). CONCLUSIONS: We identified psychological RFs that prospectively predict resilience and cofluctuate with weekly SR within individuals. These prospective results endorse that the previously reported RF-SR associations do not exclusively re

Published
2023

5. Coping with COVID: Risk and resilience factors for mental health in a German representative panel study

Author

Riepenhausen, A., Veer, I.M., Wackerhagen, C., Reppmann, Z.C., Köber, G., Ayuso-Mateos, J.L., Bögemann, S.A., Corrao, G., Felez-Nobrega, M., Abad, J.M.H., Hermans, E.J., Leeuwen, J.M.C. van, Lieb, K., Lorant, V., Mary-Krause, M., Mediavilla, R., Melchior, M., Mittendorfer-Rutz, E., Compagnoni, M.M., Pan, K.Y., Puhlmann, L.M.C., Roelofs, K., Sijbrandij, M., Smith, P., Tüscher, O., Witteveen, A.B., Zerban, M., Kalisch, R., Kröger, H., Walter, H., Riepenhausen, A., Veer, I.M., Wackerhagen, C., Reppmann, Z.C., Köber, G., Ayuso-Mateos, J.L., Bögemann, S.A., Corrao, G., Felez-Nobrega, M., Abad, J.M.H., Hermans, E.J., Leeuwen, J.M.C. van, Lieb, K., Lorant, V., Mary-Krause, M., Mediavilla, R., Melchior, M., Mittendorfer-Rutz, E., Compagnoni, M.M., Pan, K.Y., Puhlmann, L.M.C., Roelofs, K., Sijbrandij, M., Smith, P., Tüscher, O., Witteveen, A.B., Zerban, M., Kalisch, R., Kröger, H., and Walter, H.

Abstract

01 maart 2022, Item does not contain fulltext, Background: The coronavirus disease 2019 (COVID-19) pandemic might affect mental health. Data from population-representative panel surveys with multiple waves including pre-COVID data investigating risk and protective factors are still rare. Methods: In a stratified random sample of the German household population (n = 6684), we conducted survey-weighted multiple linear regressions to determine the association of various psychological risk and protective factors assessed between 2015 and 2020 with changes in psychological distress [(PD; measured via Patient Health Questionnaire for Depression and Anxiety (PHQ-4)] from pre-pandemic (average of 2016 and 2019) to peri-pandemic (both 2020 and 2021) time points. Control analyses on PD change between two pre-pandemic time points (2016 and 2019) were conducted. Regularized regressions were computed to inform on which factors were statistically most influential in the multicollinear setting. Results: PHQ-4 scores in 2020 (M = 2.45) and 2021 (M = 2.21) were elevated compared to 2019 (M = 1.79). Several risk factors (catastrophizing, neuroticism, and asking for instrumental support) and protective factors (perceived stress recovery, positive reappraisal, and optimism) were identified for the peri-pandemic outcomes. Control analyses revealed that in pre-pandemic times, neuroticism and optimism were predominantly related to PD changes. Regularized regression mostly confirmed the results and highlighted perceived stress recovery as most consistent influential protective factor across peri-pandemic outcomes. Conclusions: We identified several psychological risk and protective factors related to PD outcomes during the COVID-19 pandemic. A comparison of pre-pandemic data stresses the relevance of longitudinal assessments to potentially reconcile contradictory findings. Implications and suggestions for targeted prevention and intervention programs during highly stressful times such as pandemics are discussed.

Published
2022

6. Residential green space and air pollution are associated with brain activation in a social-stress paradigm

Author

Dimitrov-Discher, A., Wenzel, J., Kabisch, Nadja, Hemmerling, J., Bunz, M., Schöndorf, J., Walter, H., Veer, I.M., Adli, M., Dimitrov-Discher, A., Wenzel, J., Kabisch, Nadja, Hemmerling, J., Bunz, M., Schöndorf, J., Walter, H., Veer, I.M., and Adli, M.

Abstract

We examined the influence of three major environmental variables at the place of residence as potential moderating variables for neurofunctional activation during a social-stress paradigm. Data from functional magnetic resonance imaging of 42 male participants were linked to publicly accessible governmental databases providing information on amount of green space, air pollution, and noise pollution. We hypothesized that stress-related brain activation in regions important for emotion regulation were associated positively with green space and associated negatively with air pollution and noise pollution. A higher percentage of green space was associated with stronger parietal and insular activation during stress compared with that in the control condition. More air pollution was associated with weaker activation in the same (but also extended) brain regions. These findings may serve as an important reference for future studies in the emerging field of “neuro-urbanism” and emphasize the importance of environmental factors in urban planning.

Published
2022

8. Psycho-social factors associated with mental resilience in the Corona lockdown

Author

Veer, I.M. Riepenhausen, A. Zerban, M. Wackerhagen, C. Puhlmann, L.M.C. Engen, H. Köber, G. Bögemann, S.A. Weermeijer, J. Uściłko, A. Mor, N. Marciniak, M.A. Askelund, A.D. Al-Kamel, A. Ayash, S. Barsuola, G. Bartkute-Norkuniene, V. Battaglia, S. Bobko, Y. Bölte, S. Cardone, P. Chvojková, E. Damnjanović, K. De Calheiros Velozo, J. de Thurah, L. Deza-Araujo, Y.I. Dimitrov, A. Farkas, K. Feller, C. Gazea, M. Gilan, D. Gnjidić, V. Hajduk, M. Hiekkaranta, A.P. Hofgaard, L.S. Ilen, L. Kasanova, Z. Khanpour, M. Lau, B.H.P. Lenferink, D.B. Lindhardt, T.B. Magas, D.Á. Mituniewicz, J. Moreno-López, L. Muzychka, S. Ntafouli, M. O’Leary, A. Paparella, I. Põldver, N. Rintala, A. Robak, N. Rosická, A.M. Røysamb, E. Sadeghi, S. Schneider, M. Siugzdaite, R. Stantić, M. Teixeira, A. Todorovic, A. Wan, W.W.N. van Dick, R. Lieb, K. Kleim, B. Hermans, E.J. Kobylińska, D. Hendler, T. Binder, H. Myin-Germeys, I. van Leeuwen, J.M.C. Tüscher, O. Yuen, K.S.L. Walter, H. Kalisch, R.

Abstract

The SARS-CoV-2 pandemic is not only a threat to physical health but is also having severe impacts on mental health. Although increases in stress-related symptomatology and other adverse psycho-social outcomes, as well as their most important risk factors have been described, hardly anything is known about potential protective factors. Resilience refers to the maintenance of mental health despite adversity. To gain mechanistic insights about the relationship between described psycho-social resilience factors and resilience specifically in the current crisis, we assessed resilience factors, exposure to Corona crisis-specific and general stressors, as well as internalizing symptoms in a cross-sectional online survey conducted in 24 languages during the most intense phase of the lockdown in Europe (22 March to 19 April) in a convenience sample of N = 15,970 adults. Resilience, as an outcome, was conceptualized as good mental health despite stressor exposure and measured as the inverse residual between actual and predicted symptom total score. Preregistered hypotheses (osf.io/r6btn) were tested with multiple regression models and mediation analyses. Results confirmed our primary hypothesis that positive appraisal style (PAS) is positively associated with resilience (p < 0.0001). The resilience factor PAS also partly mediated the positive association between perceived social support and resilience, and its association with resilience was in turn partly mediated by the ability to easily recover from stress (both p < 0.0001). In comparison with other resilience factors, good stress response recovery and positive appraisal specifically of the consequences of the Corona crisis were the strongest factors. Preregistered exploratory subgroup analyses (osf.io/thka9) showed that all tested resilience factors generalize across major socio-demographic categories. This research identifies modifiable protective factors that can be targeted by public mental health efforts in this and in future pandemics. © 2021, The Author(s).

Published
2021

9. Resolution limit-free community detection reveals unique patterns of resting-state network connectivity in posttraumatic stress disorder: A PGC-ENIGMA PTSD consortium investigation

Author

Ross, M.C., Cisler, J.M., Koch, S.B.J., Olff, M., Veltman, D.J., Nawijn, L., Frijling, J.L., van Zuiden, M., Zhu, X., Neria, Y., Suarez-Jimenez, B., Wager, T., Morey, R.A., Haswell, C., de Bellis, M., Rubright, E.C., Stevens, J.S., van Rooij, S.J.H., Fani, N., Jovanovic, T., Ressler, K.J., Daniels, J.K., Walter, H., Manthey, A., Sierk, A., Riha, P., Rektor, I., Davidson, R., Nitschke, J., Grupe, D., Larson, C., deRoon-Cassini, T., Fitzgerald, J., Huggins, A., Weiss, C., Lanius, R., Densmore, M., Lebois, L., Kaufman, M.L., Baker, J.T., Straube, T., Neumeister, P., Hofmann, D., Etkin, A., Maron-Katz, A., King, A., Liberzon, I., Angstadt, M., Herringa, R., Wang, X., Chen, T., Cotton, A., O'Leary, B., Xie, H., Disner, S., Davenport, N., Sponheim, S., El Hage, W., Quidé, Y., Geuze, E., Kennis, M., Gordon, E., May, G., Nelson, S., Jia-Richards, M., Bruce, S., Veer, I.M., Waller, L., Berg, H., Lissek, S., Ross, M.C., Cisler, J.M., Koch, S.B.J., Olff, M., Veltman, D.J., Nawijn, L., Frijling, J.L., van Zuiden, M., Zhu, X., Neria, Y., Suarez-Jimenez, B., Wager, T., Morey, R.A., Haswell, C., de Bellis, M., Rubright, E.C., Stevens, J.S., van Rooij, S.J.H., Fani, N., Jovanovic, T., Ressler, K.J., Daniels, J.K., Walter, H., Manthey, A., Sierk, A., Riha, P., Rektor, I., Davidson, R., Nitschke, J., Grupe, D., Larson, C., deRoon-Cassini, T., Fitzgerald, J., Huggins, A., Weiss, C., Lanius, R., Densmore, M., Lebois, L., Kaufman, M.L., Baker, J.T., Straube, T., Neumeister, P., Hofmann, D., Etkin, A., Maron-Katz, A., King, A., Liberzon, I., Angstadt, M., Herringa, R., Wang, X., Chen, T., Cotton, A., O'Leary, B., Xie, H., Disner, S., Davenport, N., Sponheim, S., El Hage, W., Quidé, Y., Geuze, E., Kennis, M., Gordon, E., May, G., Nelson, S., Jia-Richards, M., Bruce, S., Veer, I.M., Waller, L., Berg, H., and Lissek, S.

Abstract

Posttraumatic stress disorder (PTSD) is a complex psychiatric condition that has generated much attention in the neuroimaging literature. A neurocircuitry model supporting fronto-limbic dysfunction as a major player in facilitating clinical symptoms of PTSD is well-characterized; however, recent literature suggests that network-based approaches may provide additional insight into neural dysfunction in PTSD. Our analysis uses resting-state neuroimaging scans of 1063 adults from the PGC-ENIGMA PTSD Consortium to investigate a network-based model of functional connectivity in PTSD. With a novel, resolution limit-free community detection approach, 16 communities corresponding to functionally meaningful networks were detected with high quality. After group-level community detection, participants were classified into three groups (PTSD, n=418, trauma-exposed controls without PTSD, n=434, and non-trauma exposed healthy controls, n=211). Individual network connectivity metrics were calculated, including whole-brain, default mode network, and central executive network participation coefficient and connectivity strength. Linear mixed effects models revealed group differences in the whole-brain, default mode, and central executive network participation coefficient and connectivity strength such that individuals with PTSD demonstrated overall greater values. We also described sex differences such that males demonstrate greater whole-brain participation coefficient vs. females and females demonstrate greater default mode network connectivity strength vs. males. Our results suggest that PTSD in adults is associated with reduced specialization and enhanced inter-module communication throughout the brain network, which may contribute to inefficient information processing and poor emotional regulation. This study presents a novel use of resolution limit-free community detection in a large PTSD sample, revealing robust differences in resting-state network topology.

Published
2021

10. Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group

Author

Han, L.K.M., Dinga, R., Hahn, T., Ching, C.R., Eyler, L.T., Aftanas, L., Aghajani, M., Aleman, A., Baune, B.T., Berger, K., Brak, I., Filho, G.B., Carballedo, A., Connolly, C.G., Couvy-Duchesne, B., Cullen, K.R., Dannlowski, U., Davey, C.G., Dima, D., Duran, F.L.S., Enneking, V., Filimonova, E., Frenzel, S., Frodl, T., Fu, C.H.Y., Godlewska, B.R., Gotlib, I.H., Grabe, H.J., Groenewold, N.A., Grotegerd, D., Gruber, O., Hall, G.B., Harrison, B.J., Hatton, S.N., Hermesdorf, M., Hickie, I.B., Ho, T.C., Hosten, N., Jansen, Andreas, Kähler, C., Kircher, T., Klimes-Dougan, B., Krämer, B., Krug, A., Lagopoulos, J., Leenings, R., MacMaster, F.P., MacQueen, G., McIntosh, A., McLellan, Q., McMahon, K.L., Medland, S.E., Mueller, B.A., Mwangi, B., Osipov, E., Portella, M.J., Pozzi, E., Reneman, L., Repple, J., Rosa, P.G., Sacchet, M.D., Sämann, P.G., Schnell, K., Schrantee, A., Simulionyte, E., Soares, J.C., Sommer, J., Stein, D.J., Steinsträter, O., Strike, L.T., Thomopoulos, S.I., Tol, M.J.D. van, Veer, I.M., Vermeiren, R., Walter, H., Wee, N.J.A. van der, Werff, S.J.A. van der, Whalley, H., Winter, N.R., Wittfeld, K., Wright, M.J., Wu, M.J., Völzke, H., Yang, T.T., Zannias, V., Zubicaray, G.I. de, Zunta-Soares, G.B., Abé, C., Alda, M., Andreassen, O.A., Bøen, E., Bonnin, C.M., Canales-Rodriguez, E.J., Cannon, D., Caseras, X., Chaim-Avancini, T.M., Elvsåshagen, T., Favre, P., Foley, S.F., Fullerton, J.M., Ruhé, H.G., Schene, A.H., Marquand, A.F., Cole, J., Schmaal, L., Han, L.K.M., Dinga, R., Hahn, T., Ching, C.R., Eyler, L.T., Aftanas, L., Aghajani, M., Aleman, A., Baune, B.T., Berger, K., Brak, I., Filho, G.B., Carballedo, A., Connolly, C.G., Couvy-Duchesne, B., Cullen, K.R., Dannlowski, U., Davey, C.G., Dima, D., Duran, F.L.S., Enneking, V., Filimonova, E., Frenzel, S., Frodl, T., Fu, C.H.Y., Godlewska, B.R., Gotlib, I.H., Grabe, H.J., Groenewold, N.A., Grotegerd, D., Gruber, O., Hall, G.B., Harrison, B.J., Hatton, S.N., Hermesdorf, M., Hickie, I.B., Ho, T.C., Hosten, N., Jansen, Andreas, Kähler, C., Kircher, T., Klimes-Dougan, B., Krämer, B., Krug, A., Lagopoulos, J., Leenings, R., MacMaster, F.P., MacQueen, G., McIntosh, A., McLellan, Q., McMahon, K.L., Medland, S.E., Mueller, B.A., Mwangi, B., Osipov, E., Portella, M.J., Pozzi, E., Reneman, L., Repple, J., Rosa, P.G., Sacchet, M.D., Sämann, P.G., Schnell, K., Schrantee, A., Simulionyte, E., Soares, J.C., Sommer, J., Stein, D.J., Steinsträter, O., Strike, L.T., Thomopoulos, S.I., Tol, M.J.D. van, Veer, I.M., Vermeiren, R., Walter, H., Wee, N.J.A. van der, Werff, S.J.A. van der, Whalley, H., Winter, N.R., Wittfeld, K., Wright, M.J., Wu, M.J., Völzke, H., Yang, T.T., Zannias, V., Zubicaray, G.I. de, Zunta-Soares, G.B., Abé, C., Alda, M., Andreassen, O.A., Bøen, E., Bonnin, C.M., Canales-Rodriguez, E.J., Cannon, D., Caseras, X., Chaim-Avancini, T.M., Elvsåshagen, T., Favre, P., Foley, S.F., Fullerton, J.M., Ruhé, H.G., Schene, A.H., Marquand, A.F., Cole, J., and Schmaal, L.

Abstract

Item does not contain fulltext, Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large multicenter international dataset. We performed a mega-analysis by pooling brain measures derived from T1-weighted MRI scans from 19 samples worldwide. Healthy brain aging was estimated by predicting chronological age (18-75 years) from 7 subcortical volumes, 34 cortical thickness and 34 surface area, lateral ventricles and total intracranial volume measures separately in 952 male and 1236 female controls from the ENIGMA MDD working group. The learned model coefficients were applied to 927 male controls and 986 depressed males, and 1199 female controls and 1689 depressed females to obtain independent unbiased brain-based age predictions. The difference between predicted "brain age" and chronological age was calculated to indicate brain-predicted age difference (brain-PAD). On average, MDD patients showed a higher brain-PAD of +1.08 (SE 0.22) years (Cohen's d = 0.14, 95% CI: 0.08-0.20) compared with controls. However, this difference did not seem to be driven by specific clinical characteristics (recurrent status, remission status, antidepressant medication use, age of onset, or symptom severity). This highly powered collaborative effort showed subtle patterns of age-related structural brain abnormalities in MDD. Substantial within-group variance and overlap between groups were observed. Longitudinal studies of MDD and somatic health outcomes are needed to further assess the clinical value of these brain-PAD estimates.

Published
2021

11. Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3–90 years

Author

Frangou, S. (Sophia), Modabbernia, A. (Amirhossein), Williams, S.C.R. (Steven C. R.), Papachristou, E. (Efstathios), Doucet, G.E. (Gaelle E.), Agartz, I. (Ingrid), Aghajani, M. (Moji), Akudjedu, T.N. (Theophilus N.), Albajes-Eizagirre, A. (Anton), Alnæs, D. (Dag), Alpert, K. (Kathryn), Andersson, M. (Micael), Andreasen, N.C. (Nancy C.), Andreassen, O.A. (Ole), Asherson, P. (Philip), Banaschewski, T. (Tobias), Bargallo, N. (Nuria), Baumeister, S. (Sarah), Baur-Streubel, R. (Ramona), Bertolino, A. (Alessandro), Bonvino, A. (Aurora), Boomsma, D.I. (Dorret I.), Borgwardt, S. (Stefan), Bourque, J. (Josiane), Brandeis, D. (Daniel), Breier, A. (Alan), Brodaty, H. (Henry), Brouwer, R.M. (Rachel), Buitelaar, J.K. (Jan K.), Busatto, G.F. (Geraldo F.), Buckner, M., Calhoun, V.D. (Vince), Canales-Rodríguez, E.J. (Erick J.), Cannon, D.M. (Dara M.), Caseras, X. (Xavier), Castellanos, F.X. (Francisco X.), Cervenka, S. (Simon), Chaim-Avancini, T.M. (Tiffany M.), Ching, C.R.K. (Christopher), Chubar, V. (Victoria), Clark, V.P. (Vincent P.), Conrod, P. (Patricia), Conzelmann, A. (Annette), Crespo-Facorro, B. (Benedicto), Crivello, F. (Fabrice), Crone, E.A. (Eveline), Dale, A.M. (Anders), Davey, C.G. (Christopher), Geus, E.J.C. (Eco) de, Haan, L. (Lieuwe) de, Zubicaray, G.I. (Greig) de, Braber, A. (Anouk) den, Dickie, E.W. (Erin W.), Di Giorgio, A. (Annabella), Doan, N.T. (Nhat Trung), Dørum, E.S. (Erlend S.), Ehrlich, S.M. (Stefan), Erk, S., Espeseth, T. (Thomas), Fatouros-Bergman, H. (Helena), Fisher, S.E. (Simon), Fouche, J.-P. (Jean-Paul), Franke, B. (Barbara), Frodl, T. (Thomas), Fuentes-Claramonte, P. (Paola), Glahn, D.C. (David), Gotlib, I.H. (Ian H.), Grabe, H.J. (Hans Jörgen), Grimm, O. (Oliver), Groenewold, N.A. (Nynke A.), Grotegerd, D. (Dominik), Gruber, O. (Oliver), Gruner, P. (Patricia), Gur, R.E. (Rachel E.), Gur, R.C. (Ruben C.), Harrison, B.J. (Ben J.), Hartman, C.A. (Catharine A.), Hatton, W., Heinz, A. (Andreas), Heslenfeld, D.J. (Dirk), Hibar, D.P. (Derrek P.), Hickie, I.B. (Ian), Ho, B.-C. (Beng-Choon), Hoekstra, P.J. (Pieter), Hohmann, S. (Sarah), Holmes, A.J. (Avram J.), Hoogman, M. (Martine), Hosten, N. (Norbert), Howells, F.M. (Fleur M.), Hulshoff Pol, H.E. (Hilleke E.), Huyser, J. (Jochanan), Jahanshad, N. (Neda), James, A., Jernigan, T.L. (Terry L.), Jiang, J. (Jiyang), Jönsson, E.G. (Erik G.), Joska, J.A. (John A.), Kahn, R. (Rene), Kalnin, A. (Andrew), Kanai, R. (Ryota), Klein, M. (Marieke), Klyushnik, T.P. (Tatyana P.), Koenders, L. (Laura), Koops, S. (Sanne), Krämer, B. (Bernd), Kuntsi, J. (Jonna), Lagopoulos, J. (Jim), Lázaro, L. (Luisa), Lebedeva, I. (Irina), Lee, W.H. (Won Hee), Lesch, K.-P. (Klaus-Peter), Lochner, C. (Christine), Machielsen, M.W.J. (Marise), Maingault, S. (Sophie), Martin, N.G. (Nicholas G.), Martínez-Zalacaín, I. (Ignacio), Mataix-Cols, D. (David), Mazoyer, B. (Bernard), McDonald, C. (Colm), McDonald, B.C. (Brenna C.), McIntosh, A.M. (Andrew), McMahon, K.L. (Katie L.), McPhilemy, G. (Genevieve), Menchón, J.M. (José M.), Medland, S.E. (Sarah), Meyer-Lindenberg, A. (Andreas), Naaijen, J. (Jilly), Najt, P. (Pablo), Nakao, T. (Tomohiro), Nordvik, J.E. (Jan E.), Nyberg, L. (Lisa), Oosterlaan, J. (Jaap), de la Foz, V.O.-G. (Víctor Ortiz-García), Paloyelis, Y. (Yannis), Pauli, P. (Paul), Pergola, G. (Giulio), Pomarol-Clotet, E. (Edith), Portella, M.J. (Maria J.), Potkin, S.G. (Steven G.), Radua, J. (Joaquim), Reif, A. (Andreas), Rinker, D.A. (Daniel A.), Roffman, J.L. (Joshua), Rosa, P.G.P. (Pedro G. P.), Sacchet, M.D. (Matthew D.), Sachdev, P.S. (Perminder), Salvador, R. (Raymond), Sánchez-Juan, P. (Pascual), Sarró, S. (Salvador), Satterthwaite, T.D. (Theodore), Saykin, A.J. (Andrew), Serpa, M.H. (Mauricio H.), Schmaal, L. (Lianne), Schnell, K. (Kerry), Schumann, G. (Gunter), Sim, K. (Kang), Smoller, J.W., Sommer, I. (Iris), Soriano-Mas, C. (Carles), Stein, D.J. (Dan J.), Strike, L.T. (Lachlan), Swagerman, S.C. (Suzanne C.), Tamnes, C.K. (Christian K.), Temmingh, H.S. (Henk S.), Thomopoulos, S.I. (Sophia I.), Tomyshev, A.S. (Alexander S.), Tordesillas-Gutierrez, D. (Diana), Trollor, J., Turner, J.A. (Jessica A.), Uhlmann, A. (Anne), Heuvel, O.A. (Odile A.), van den Meer, D. (Dennis), Wee, N.J. (Nic) van der, van Haren, N.E.M. (Neeltje E. M.), Ent, D. (Dennis) van 't, Erp, T.G.M. (Theo G.) van, Veer, I.M. (Ilya), Veltman, D.J. (Dick), Voineskos, A. (Aristotle), Völzke, H. (Henry), Walter, H. (Henrik), Walton, E. (Esther), Wang, L. (Lei), Wang, Y. (Yang), Wassink, A.M.J. (Annemarie), Weber, B. (Bernd), Wen, W. (Wei), West, J.D. (John D.), Westlye, L.T. (Lars), Whalley, H. (Heather), Wierenga, L.M. (Lara M.), Wittfeld, K. (Katharina), Wolf, D.H. (Daniel H.), Worker, A. (Amanda), Wright, M.J. (Margaret J.), Yang, K. (Kun), Yoncheva, Y. (Yulyia), Zanetti, M.V. (Marcus V.), Ziegler, G.C. (Georg C.), Thompson, P.M. (Paul), Dima, D. (Danai), Frangou, S. (Sophia), Modabbernia, A. (Amirhossein), Williams, S.C.R. (Steven C. R.), Papachristou, E. (Efstathios), Doucet, G.E. (Gaelle E.), Agartz, I. (Ingrid), Aghajani, M. (Moji), Akudjedu, T.N. (Theophilus N.), Albajes-Eizagirre, A. (Anton), Alnæs, D. (Dag), Alpert, K. (Kathryn), Andersson, M. (Micael), Andreasen, N.C. (Nancy C.), Andreassen, O.A. (Ole), Asherson, P. (Philip), Banaschewski, T. (Tobias), Bargallo, N. (Nuria), Baumeister, S. (Sarah), Baur-Streubel, R. (Ramona), Bertolino, A. (Alessandro), Bonvino, A. (Aurora), Boomsma, D.I. (Dorret I.), Borgwardt, S. (Stefan), Bourque, J. (Josiane), Brandeis, D. (Daniel), Breier, A. (Alan), Brodaty, H. (Henry), Brouwer, R.M. (Rachel), Buitelaar, J.K. (Jan K.), Busatto, G.F. (Geraldo F.), Buckner, M., Calhoun, V.D. (Vince), Canales-Rodríguez, E.J. (Erick J.), Cannon, D.M. (Dara M.), Caseras, X. (Xavier), Castellanos, F.X. (Francisco X.), Cervenka, S. (Simon), Chaim-Avancini, T.M. (Tiffany M.), Ching, C.R.K. (Christopher), Chubar, V. (Victoria), Clark, V.P. (Vincent P.), Conrod, P. (Patricia), Conzelmann, A. (Annette), Crespo-Facorro, B. (Benedicto), Crivello, F. (Fabrice), Crone, E.A. (Eveline), Dale, A.M. (Anders), Davey, C.G. (Christopher), Geus, E.J.C. (Eco) de, Haan, L. (Lieuwe) de, Zubicaray, G.I. (Greig) de, Braber, A. (Anouk) den, Dickie, E.W. (Erin W.), Di Giorgio, A. (Annabella), Doan, N.T. (Nhat Trung), Dørum, E.S. (Erlend S.), Ehrlich, S.M. (Stefan), Erk, S., Espeseth, T. (Thomas), Fatouros-Bergman, H. (Helena), Fisher, S.E. (Simon), Fouche, J.-P. (Jean-Paul), Franke, B. (Barbara), Frodl, T. (Thomas), Fuentes-Claramonte, P. (Paola), Glahn, D.C. (David), Gotlib, I.H. (Ian H.), Grabe, H.J. (Hans Jörgen), Grimm, O. (Oliver), Groenewold, N.A. (Nynke A.), Grotegerd, D. (Dominik), Gruber, O. (Oliver), Gruner, P. (Patricia), Gur, R.E. (Rachel E.), Gur, R.C. (Ruben C.), Harrison, B.J. (Ben J.), Hartman, C.A. (Catharine A.), Hatton, W., Heinz, A. (Andreas), Heslenfeld, D.J. (Dirk), Hibar, D.P. (Derrek P.), Hickie, I.B. (Ian), Ho, B.-C. (Beng-Choon), Hoekstra, P.J. (Pieter), Hohmann, S. (Sarah), Holmes, A.J. (Avram J.), Hoogman, M. (Martine), Hosten, N. (Norbert), Howells, F.M. (Fleur M.), Hulshoff Pol, H.E. (Hilleke E.), Huyser, J. (Jochanan), Jahanshad, N. (Neda), James, A., Jernigan, T.L. (Terry L.), Jiang, J. (Jiyang), Jönsson, E.G. (Erik G.), Joska, J.A. (John A.), Kahn, R. (Rene), Kalnin, A. (Andrew), Kanai, R. (Ryota), Klein, M. (Marieke), Klyushnik, T.P. (Tatyana P.), Koenders, L. (Laura), Koops, S. (Sanne), Krämer, B. (Bernd), Kuntsi, J. (Jonna), Lagopoulos, J. (Jim), Lázaro, L. (Luisa), Lebedeva, I. (Irina), Lee, W.H. (Won Hee), Lesch, K.-P. (Klaus-Peter), Lochner, C. (Christine), Machielsen, M.W.J. (Marise), Maingault, S. (Sophie), Martin, N.G. (Nicholas G.), Martínez-Zalacaín, I. (Ignacio), Mataix-Cols, D. (David), Mazoyer, B. (Bernard), McDonald, C. (Colm), McDonald, B.C. (Brenna C.), McIntosh, A.M. (Andrew), McMahon, K.L. (Katie L.), McPhilemy, G. (Genevieve), Menchón, J.M. (José M.), Medland, S.E. (Sarah), Meyer-Lindenberg, A. (Andreas), Naaijen, J. (Jilly), Najt, P. (Pablo), Nakao, T. (Tomohiro), Nordvik, J.E. (Jan E.), Nyberg, L. (Lisa), Oosterlaan, J. (Jaap), de la Foz, V.O.-G. (Víctor Ortiz-García), Paloyelis, Y. (Yannis), Pauli, P. (Paul), Pergola, G. (Giulio), Pomarol-Clotet, E. (Edith), Portella, M.J. (Maria J.), Potkin, S.G. (Steven G.), Radua, J. (Joaquim), Reif, A. (Andreas), Rinker, D.A. (Daniel A.), Roffman, J.L. (Joshua), Rosa, P.G.P. (Pedro G. P.), Sacchet, M.D. (Matthew D.), Sachdev, P.S. (Perminder), Salvador, R. (Raymond), Sánchez-Juan, P. (Pascual), Sarró, S. (Salvador), Satterthwaite, T.D. (Theodore), Saykin, A.J. (Andrew), Serpa, M.H. (Mauricio H.), Schmaal, L. (Lianne), Schnell, K. (Kerry), Schumann, G. (Gunter), Sim, K. (Kang), Smoller, J.W., Sommer, I. (Iris), Soriano-Mas, C. (Carles), Stein, D.J. (Dan J.), Strike, L.T. (Lachlan), Swagerman, S.C. (Suzanne C.), Tamnes, C.K. (Christian K.), Temmingh, H.S. (Henk S.), Thomopoulos, S.I. (Sophia I.), Tomyshev, A.S. (Alexander S.), Tordesillas-Gutierrez, D. (Diana), Trollor, J., Turner, J.A. (Jessica A.), Uhlmann, A. (Anne), Heuvel, O.A. (Odile A.), van den Meer, D. (Dennis), Wee, N.J. (Nic) van der, van Haren, N.E.M. (Neeltje E. M.), Ent, D. (Dennis) van 't, Erp, T.G.M. (Theo G.) van, Veer, I.M. (Ilya), Veltman, D.J. (Dick), Voineskos, A. (Aristotle), Völzke, H. (Henry), Walter, H. (Henrik), Walton, E. (Esther), Wang, L. (Lei), Wang, Y. (Yang), Wassink, A.M.J. (Annemarie), Weber, B. (Bernd), Wen, W. (Wei), West, J.D. (John D.), Westlye, L.T. (Lars), Whalley, H. (Heather), Wierenga, L.M. (Lara M.), Wittfeld, K. (Katharina), Wolf, D.H. (Daniel H.), Worker, A. (Amanda), Wright, M.J. (Margaret J.), Yang, K. (Kun), Yoncheva, Y. (Yulyia), Zanetti, M.V. (Marcus V.), Ziegler, G.C. (Georg C.), Thompson, P.M. (Paul), and Dima, D. (Danai)

Abstract

Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3–90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes.

Published
2021
Full Text
View/download PDF

12. Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years

Author

Dima, D. (Danai), Modabbernia, A. (Amirhossein), Papachristou, E. (Efstathios), Doucet, G.E. (Gaelle E.), Agartz, I. (Ingrid), Aghajani, M. (Moji), Akudjedu, T.N. (Theophilus N.), Albajes-Eizagirre, A. (Anton), Alnæs, D. (Dag), Alpert, K. (Kathryn), Andersson, M. (Micael), Andreasen, N.C. (Nancy C.), Andreassen, O.A. (Ole), Asherson, P. (Philip), Banaschewski, T. (Tobias), Bargallo, N. (Nuria), Baumeister, S. (Sarah), Baur-Streubel, R. (Ramona), Bertolino, A. (Alessandro), Bonvino, A. (Aurora), Boomsma, D.I. (Dorret I.), Borgwardt, S. (Stefan), Bourque, J. (Josiane), Brandeis, D. (Daniel), Breier, A. (Alan), Brodaty, H. (Henry), Brouwer, R.M. (Rachel), Buitelaar, J.K. (Jan K.), Busatto, G.F. (Geraldo F.), Buckner, M., Calhoun, V.D. (Vince), Canales-Rodríguez, E.J. (Erick J.), Cannon, D.M. (Dara M.), Caseras, X. (Xavier), Castellanos, F.X. (Francisco X.), Cervenka, S. (Simon), Chaim-Avancini, T.M. (Tiffany M.), Ching, C.R.K. (Christopher), Chubar, V. (Victoria), Clark, V.P. (Vincent P.), Conrod, P. (Patricia), Conzelmann, A. (Annette), Crespo-Facorro, B. (Benedicto), Crivello, F. (Fabrice), Crone, E.A. (Eveline), Dale, A.M. (Anders), Davey, C.G. (Christopher), Geus, E.J.C. (Eco) de, Haan, L. (Lieuwe) de, Zubicaray, G.I. (Greig) de, Braber, A. (Anouk) den, Dickie, E.W. (Erin W.), Di Giorgio, A. (Annabella), Doan, N.T. (Nhat Trung), Dørum, E.S. (Erlend S.), Ehrlich, S.M. (Stefan), Erk, S., Espeseth, T. (Thomas), Fatouros-Bergman, H. (Helena), Fisher, S.E. (Simon), Fouche, J.-P. (Jean-Paul), Franke, B. (Barbara), Frodl, T. (Thomas), Fuentes-Claramonte, P. (Paola), Glahn, D.C. (David), Gotlib, I.H. (Ian H.), Grabe, H.J. (Hans Jörgen), Grimm, O. (Oliver), Groenewold, N.A. (Nynke A.), Grotegerd, D. (Dominik), Gruber, O. (Oliver), Gruner, P. (Patricia), Gur, R.E. (Rachel E.), Gur, R.C. (Ruben C.), Harrison, B.J. (Ben J.), Hartman, C.A. (Catharine A.), Hatton, W., Heinz, A. (Andreas), Heslenfeld, D.J. (Dirk), Hibar, D.P. (Derrek P.), Hickie, I.B. (Ian), Ho, B.-C. (Beng-Choon), Hoekstra, P.J. (Pieter), Hohmann, S. (Sarah), Holmes, A.J. (Avram J.), Hoogman, M. (Martine), Hosten, N. (Norbert), Howells, F.M. (Fleur M.), Hulshoff Pol, H.E. (Hilleke E.), Huyser, J. (Jochanan), Jahanshad, N. (Neda), James, A., Jernigan, T.L. (Terry L.), Jiang, J. (Jiyang), Jönsson, E.G. (Erik G.), Joska, J.A. (John A.), Kahn, R. (Rene), Kalnin, A. (Andrew), Kanai, R. (Ryota), Klein, M. (Marieke), Klyushnik, T.P. (Tatyana P.), Koenders, L. (Laura), Koops, S. (Sanne), Krämer, B. (Bernd), Kuntsi, J. (Jonna), Lagopoulos, J. (Jim), Lázaro, L. (Luisa), Lebedeva, I. (Irina), Lee, W.H. (Won Hee), Lesch, K.-P. (Klaus-Peter), Lochner, C. (Christine), Machielsen, M.W.J. (Marise), Maingault, S. (Sophie), Martin, N.G. (Nicholas G.), Martínez-Zalacaín, I. (Ignacio), Mataix-Cols, D. (David), Mazoyer, B. (Bernard), McDonald, C. (Colm), McDonald, B.C. (Brenna C.), McIntosh, A.M. (Andrew), McMahon, K.L. (Katie L.), McPhilemy, G. (Genevieve), Menchón, J.M. (José M.), Medland, S.E. (Sarah), Meyer-Lindenberg, A. (Andreas), Naaijen, J. (Jilly), Najt, P. (Pablo), Nakao, T. (Tomohiro), Nordvik, J.E. (Jan E.), Nyberg, L., Oosterlaan, J. (Jaap), de la Foz, V.O.-G. (Víctor Ortiz-García), Paloyelis, Y. (Yannis), Pauli, P. (Paul), Pergola, G. (Giulio), Pomarol-Clotet, E. (Edith), Portella, M.J. (Maria J.), Potkin, S.G. (Steven G.), Radua, J. (Joaquim), Reif, A. (Andreas), Rinker, D.A. (Daniel A.), Roffman, J.L. (Joshua), Rosa, P.G.P. (Pedro G. P.), Sacchet, M.D. (Matthew D.), Sachdev, P.S. (Perminder), Salvador, R. (Raymond), Sánchez-Juan, P. (Pascual), Sarró, S. (Salvador), Satterthwaite, T.D. (Theodore), Saykin, A.J. (Andrew), Serpa, M.H. (Mauricio H.), Schmaal, L. (Lianne), Schnell, K. (Kerry), Schumann, G. (Gunter), Sim, K. (Kang), Smoller, J.W., Sommer, I. (Iris), Soriano-Mas, C. (Carles), Stein, D.J. (Dan J.), Strike, L.T. (Lachlan), Swagerman, S.C. (Suzanne C.), Tamnes, C.K. (Christian K.), Temmingh, H.S. (Henk S.), Thomopoulos, S.I. (Sophia I.), Tomyshev, A.S. (Alexander S.), Tordesillas-Gutierrez, D. (Diana), Trollor, J., Turner, J.A. (Jessica A.), Uhlmann, A. (Anne), Heuvel, O.A. (Odile A.), van den Meer, D. (Dennis), Wee, N.J. (Nic) van der, van Haren, N.E.M. (Neeltje E. M.), van't Ent, D. (Dennis), Erp, T.G.M. (Theo G.) van, Veer, I.M. (Ilya), Veltman, D.J. (Dick), Voineskos, A. (Aristotle), Völzke, H. (Henry), Walter, H. (Henrik), Walton, E. (Esther), Wang, L. (Lei), Wang, Y. (Yang), Wassink, A.M.J. (Annemarie), Weber, B. (Bernd), Wen, W. (Wei), West, J.D. (John D.), Westlye, L.T. (Lars), Whalley, H. (Heather), Wierenga, L.M. (Lara M.), Williams, S.C.R. (Steven C. R.), Wittfeld, K. (Katharina), Wolf, D.H. (Daniel H.), Worker, A. (Amanda), Wright, M.J. (Margaret J.), Yang, K. (Kun), Yoncheva, Y. (Yulyia), Zanetti, M.V. (Marcus V.), Ziegler, G.C. (Georg C.), Thompson, P.M. (Paul), Frangou, S. (Sophia), Dima, D. (Danai), Modabbernia, A. (Amirhossein), Papachristou, E. (Efstathios), Doucet, G.E. (Gaelle E.), Agartz, I. (Ingrid), Aghajani, M. (Moji), Akudjedu, T.N. (Theophilus N.), Albajes-Eizagirre, A. (Anton), Alnæs, D. (Dag), Alpert, K. (Kathryn), Andersson, M. (Micael), Andreasen, N.C. (Nancy C.), Andreassen, O.A. (Ole), Asherson, P. (Philip), Banaschewski, T. (Tobias), Bargallo, N. (Nuria), Baumeister, S. (Sarah), Baur-Streubel, R. (Ramona), Bertolino, A. (Alessandro), Bonvino, A. (Aurora), Boomsma, D.I. (Dorret I.), Borgwardt, S. (Stefan), Bourque, J. (Josiane), Brandeis, D. (Daniel), Breier, A. (Alan), Brodaty, H. (Henry), Brouwer, R.M. (Rachel), Buitelaar, J.K. (Jan K.), Busatto, G.F. (Geraldo F.), Buckner, M., Calhoun, V.D. (Vince), Canales-Rodríguez, E.J. (Erick J.), Cannon, D.M. (Dara M.), Caseras, X. (Xavier), Castellanos, F.X. (Francisco X.), Cervenka, S. (Simon), Chaim-Avancini, T.M. (Tiffany M.), Ching, C.R.K. (Christopher), Chubar, V. (Victoria), Clark, V.P. (Vincent P.), Conrod, P. (Patricia), Conzelmann, A. (Annette), Crespo-Facorro, B. (Benedicto), Crivello, F. (Fabrice), Crone, E.A. (Eveline), Dale, A.M. (Anders), Davey, C.G. (Christopher), Geus, E.J.C. (Eco) de, Haan, L. (Lieuwe) de, Zubicaray, G.I. (Greig) de, Braber, A. (Anouk) den, Dickie, E.W. (Erin W.), Di Giorgio, A. (Annabella), Doan, N.T. (Nhat Trung), Dørum, E.S. (Erlend S.), Ehrlich, S.M. (Stefan), Erk, S., Espeseth, T. (Thomas), Fatouros-Bergman, H. (Helena), Fisher, S.E. (Simon), Fouche, J.-P. (Jean-Paul), Franke, B. (Barbara), Frodl, T. (Thomas), Fuentes-Claramonte, P. (Paola), Glahn, D.C. (David), Gotlib, I.H. (Ian H.), Grabe, H.J. (Hans Jörgen), Grimm, O. (Oliver), Groenewold, N.A. (Nynke A.), Grotegerd, D. (Dominik), Gruber, O. (Oliver), Gruner, P. (Patricia), Gur, R.E. (Rachel E.), Gur, R.C. (Ruben C.), Harrison, B.J. (Ben J.), Hartman, C.A. (Catharine A.), Hatton, W., Heinz, A. (Andreas), Heslenfeld, D.J. (Dirk), Hibar, D.P. (Derrek P.), Hickie, I.B. (Ian), Ho, B.-C. (Beng-Choon), Hoekstra, P.J. (Pieter), Hohmann, S. (Sarah), Holmes, A.J. (Avram J.), Hoogman, M. (Martine), Hosten, N. (Norbert), Howells, F.M. (Fleur M.), Hulshoff Pol, H.E. (Hilleke E.), Huyser, J. (Jochanan), Jahanshad, N. (Neda), James, A., Jernigan, T.L. (Terry L.), Jiang, J. (Jiyang), Jönsson, E.G. (Erik G.), Joska, J.A. (John A.), Kahn, R. (Rene), Kalnin, A. (Andrew), Kanai, R. (Ryota), Klein, M. (Marieke), Klyushnik, T.P. (Tatyana P.), Koenders, L. (Laura), Koops, S. (Sanne), Krämer, B. (Bernd), Kuntsi, J. (Jonna), Lagopoulos, J. (Jim), Lázaro, L. (Luisa), Lebedeva, I. (Irina), Lee, W.H. (Won Hee), Lesch, K.-P. (Klaus-Peter), Lochner, C. (Christine), Machielsen, M.W.J. (Marise), Maingault, S. (Sophie), Martin, N.G. (Nicholas G.), Martínez-Zalacaín, I. (Ignacio), Mataix-Cols, D. (David), Mazoyer, B. (Bernard), McDonald, C. (Colm), McDonald, B.C. (Brenna C.), McIntosh, A.M. (Andrew), McMahon, K.L. (Katie L.), McPhilemy, G. (Genevieve), Menchón, J.M. (José M.), Medland, S.E. (Sarah), Meyer-Lindenberg, A. (Andreas), Naaijen, J. (Jilly), Najt, P. (Pablo), Nakao, T. (Tomohiro), Nordvik, J.E. (Jan E.), Nyberg, L., Oosterlaan, J. (Jaap), de la Foz, V.O.-G. (Víctor Ortiz-García), Paloyelis, Y. (Yannis), Pauli, P. (Paul), Pergola, G. (Giulio), Pomarol-Clotet, E. (Edith), Portella, M.J. (Maria J.), Potkin, S.G. (Steven G.), Radua, J. (Joaquim), Reif, A. (Andreas), Rinker, D.A. (Daniel A.), Roffman, J.L. (Joshua), Rosa, P.G.P. (Pedro G. P.), Sacchet, M.D. (Matthew D.), Sachdev, P.S. (Perminder), Salvador, R. (Raymond), Sánchez-Juan, P. (Pascual), Sarró, S. (Salvador), Satterthwaite, T.D. (Theodore), Saykin, A.J. (Andrew), Serpa, M.H. (Mauricio H.), Schmaal, L. (Lianne), Schnell, K. (Kerry), Schumann, G. (Gunter), Sim, K. (Kang), Smoller, J.W., Sommer, I. (Iris), Soriano-Mas, C. (Carles), Stein, D.J. (Dan J.), Strike, L.T. (Lachlan), Swagerman, S.C. (Suzanne C.), Tamnes, C.K. (Christian K.), Temmingh, H.S. (Henk S.), Thomopoulos, S.I. (Sophia I.), Tomyshev, A.S. (Alexander S.), Tordesillas-Gutierrez, D. (Diana), Trollor, J., Turner, J.A. (Jessica A.), Uhlmann, A. (Anne), Heuvel, O.A. (Odile A.), van den Meer, D. (Dennis), Wee, N.J. (Nic) van der, van Haren, N.E.M. (Neeltje E. M.), van't Ent, D. (Dennis), Erp, T.G.M. (Theo G.) van, Veer, I.M. (Ilya), Veltman, D.J. (Dick), Voineskos, A. (Aristotle), Völzke, H. (Henry), Walter, H. (Henrik), Walton, E. (Esther), Wang, L. (Lei), Wang, Y. (Yang), Wassink, A.M.J. (Annemarie), Weber, B. (Bernd), Wen, W. (Wei), West, J.D. (John D.), Westlye, L.T. (Lars), Whalley, H. (Heather), Wierenga, L.M. (Lara M.), Williams, S.C.R. (Steven C. R.), Wittfeld, K. (Katharina), Wolf, D.H. (Daniel H.), Worker, A. (Amanda), Wright, M.J. (Margaret J.), Yang, K. (Kun), Yoncheva, Y. (Yulyia), Zanetti, M.V. (Marcus V.), Ziegler, G.C. (Georg C.), Thompson, P.M. (Paul), and Frangou, S. (Sophia)

Abstract

Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3–90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns.

Published
2020
Full Text
View/download PDF

13. ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

Author

Thompson, P.M. (Paul), Jahanshad, N. (Neda), Ching, C.R.K. (Christopher), Salminen, L.E. (Lauren E.), Thomopoulos, S.I. (Sophia I.), Bright, J. (Joanna), Baune, B.T., Bertolín, S. (Sara), Bralten, L.B.C. (Linda), Bruin, W.B. (Willem B.), Bülow, R. (Robin), Chen, J. (Jian), Chye, Y. (Yann), Dannlowski, U. (Udo), de Kovel, C.G.F. (Carolien G F), Donohoe, D.J. (Dennis), Eyler, L.T. (Lisa T.), Faraone, S.V. (Stephen), Favre, P. (Pauline), Filippi, C.A. (Courtney A.), Frodl, T. (Thomas), Garijo, D. (Daniel), Gil, Y. (Yolanda), Grabe, H.J. (Hans Jörgen), Grasby, K.L. (Katrina L.), Hajek, T. (Tomas), Han, L.K.M. (Laura K M), Hatton, W., Hilbert, K. (Kevin), Ho, T.C. (Tiffany C.), Holleran, L. (Laurena), Homuth, G. (Georg), Hosten, N. (Norbert), Houenou, J. (Josselin), Ivanov, I. (Iliyan), Jia, T. (Tianye), Kelly, S. (Sinead), Klein, M. (Marieke), Kwon, J.S. (Jun Soo), Laansma, M.A. (Max A.), Leerssen, J. (Jeanne), Lueken, U. (Ulrike), Nunes, A. (Abraham), Neill, J.O. (Joseph O'), Opel, N. (Nils), Piras, F. (Fabrizio), Piras, F. (Federica), Postema, M.C. (Merel C.), Pozzi, E. (Elena), Shatokhina, N. (Natalia), Soriano-Mas, C. (Carles), Spalletta, G. (Gianfranco), Sun, D. (Daqiang), Teumer, A. (Alexander), Tilot, A.K. (Amanda K.), Tozzi, L. (Leonardo), van der Merwe, C. (Celia), Someren, E.J.W. (Eus) van, van Wingen, G.A. (Guido A.), Völzke, H. (Henry), Walton, E. (Esther), Wang, L. (Lei), Winkler, A.M. (Anderson), Wittfeld, K. (Katharina), Wright, M.J. (Margaret), Yun, J.-Y. (Je-Yeon), Zhang, G. (Guohao), Zhang-James, Y. (Yanli), Adhikari, B.M. (Bhim M.), Agartz, I. (Ingrid), Aghajani, M. (Moji), Aleman, A. (André), Althoff, R.R. (Robert R.), Altmann, A. (A.), Andreassen, O.A. (Ole), Baron, D.A. (David A.), Bartnik-Olson, B.L. (Brenda L.), Marie Bas-Hoogendam, J. (Janna), Baskin-Sommers, A.R. (Arielle R.), Bearden, C.E. (Carrie), Berner, L.A. (Laura A.), Boedhoe, P.S.W. (Premika S W), Brouwer, R.M. (Rachel), Buitelaar, J.K. (Jan), Caeyenberghs, K. (Karen), Cecil, C.A.M. (Charlotte), Cohen, R.A. (Ronald A.), Cole, J.H. (James H.), Conrod, P. (Patricia), De Brito, S.A. (Stephane A.), de Zwarte, S.M.C. (Sonja M C), Dennis, E.L. (Emily L.), Desrivieres, S. (Sylvane), Dima, D. (Danai), Ehrlich, S.M. (Stefan), Esopenko, C. (Carrie), Fairchild, G. (Graeme), Fisher, S.E. (Simon), Fouche, J.-P. (Jean-Paul), Francks, C. (Clyde), Frangou, S. (Sophia), Franke, B. (Barbara), Garavan, H.P. (Hugh P.), Glahn, D.C. (David), Groenewold, N.A. (Nynke A.), Gurholt, T.P. (Tiril P.), Gutman, B.A. (Boris A.), Hahn, T. (Tim), Harding, I.H. (Ian H.), Hernaus, D. (Dennis), Hibar, D.P. (Derrek P.), Hillary, F.G. (Frank G.), Hoogman, M. (Martine), Hulshoff Pol, H.E. (Hilleke E.), Jalbrzikowski, M. (Maria), Karkashadze, G.A. (George A.), Klapwijk, E.T. (Eduard T.), Knickmeyer, R.C. (Rebecca C.), Kochunov, P. (Peter), Koerte, I.K. (Inga K.), Kong, X.-Z. (Xiang-Zhen), Liew, S.-L. (Sook-Lei), Lin, A.P. (Alexander P.), Logue, M.W. (Mark W.), Luders, E. (Eileen), Macciardi, F. (Fabio), Mackey, S. (Scott), Mayer, A.R. (Andrew R.), McDonald, C.R. (Carrie R.), McMahon, A.B. (Agnes B.), Medland, S.E. (Sarah), Modinos, G. (Gemma), Morey, R.A. (Rajendra A.), Mueller, S.C. (Sven C.), Mukherjee, P. (Pratik), Namazova-Baranova, L. (L.), Nir, T.M. (Talia M.), Olsen, A. (Alexander), Paschou, P. (Peristera), Pine, D.S. (Daniel S.), Pizzagalli, F. (Fabrizio), Rentería, M.E. (Miguel), Rohrer, J.D. (Jonathan D.), Sämann, P.G. (Philipp), Schmaal, L. (Lianne), Schumann, G. (Gunter), Shiroishi, M.S. (Mark S.), Sisodiya, S.M. (Sanjay), Smit, D.J.A. (Dirk J A), Sønderby, I.E. (Ida E.), Stein, D.J. (Dan J.), Stein, J.L., Tahmasian, M. (Masoud), Tate, D.F. (David F.), Turner, J. (Jessica), Heuvel, O.A. (Odile A.), Wee, N.J. (Nic) van der, van der Werf, Y.D. (Ysbrand), Erp, T.G.M. (Theo G.) van, van Haren, N.E.M. (Neeltje E M), van Rooij, D. (Daan), Van Velzen, L.S., Veer, I.M. (Ilya), Veltman, D.J. (Dick), Villalon-Reina, J.E. (Julio E.), Walter, H.J. (Henrik), Whelan, C.D. (Christopher), Wilde, E.A. (Elisabeth A.), Zarei, M. (Mojtaba), Zelman, V. (Vladimir), Thompson, P.M. (Paul), Jahanshad, N. (Neda), Ching, C.R.K. (Christopher), Salminen, L.E. (Lauren E.), Thomopoulos, S.I. (Sophia I.), Bright, J. (Joanna), Baune, B.T., Bertolín, S. (Sara), Bralten, L.B.C. (Linda), Bruin, W.B. (Willem B.), Bülow, R. (Robin), Chen, J. (Jian), Chye, Y. (Yann), Dannlowski, U. (Udo), de Kovel, C.G.F. (Carolien G F), Donohoe, D.J. (Dennis), Eyler, L.T. (Lisa T.), Faraone, S.V. (Stephen), Favre, P. (Pauline), Filippi, C.A. (Courtney A.), Frodl, T. (Thomas), Garijo, D. (Daniel), Gil, Y. (Yolanda), Grabe, H.J. (Hans Jörgen), Grasby, K.L. (Katrina L.), Hajek, T. (Tomas), Han, L.K.M. (Laura K M), Hatton, W., Hilbert, K. (Kevin), Ho, T.C. (Tiffany C.), Holleran, L. (Laurena), Homuth, G. (Georg), Hosten, N. (Norbert), Houenou, J. (Josselin), Ivanov, I. (Iliyan), Jia, T. (Tianye), Kelly, S. (Sinead), Klein, M. (Marieke), Kwon, J.S. (Jun Soo), Laansma, M.A. (Max A.), Leerssen, J. (Jeanne), Lueken, U. (Ulrike), Nunes, A. (Abraham), Neill, J.O. (Joseph O'), Opel, N. (Nils), Piras, F. (Fabrizio), Piras, F. (Federica), Postema, M.C. (Merel C.), Pozzi, E. (Elena), Shatokhina, N. (Natalia), Soriano-Mas, C. (Carles), Spalletta, G. (Gianfranco), Sun, D. (Daqiang), Teumer, A. (Alexander), Tilot, A.K. (Amanda K.), Tozzi, L. (Leonardo), van der Merwe, C. (Celia), Someren, E.J.W. (Eus) van, van Wingen, G.A. (Guido A.), Völzke, H. (Henry), Walton, E. (Esther), Wang, L. (Lei), Winkler, A.M. (Anderson), Wittfeld, K. (Katharina), Wright, M.J. (Margaret), Yun, J.-Y. (Je-Yeon), Zhang, G. (Guohao), Zhang-James, Y. (Yanli), Adhikari, B.M. (Bhim M.), Agartz, I. (Ingrid), Aghajani, M. (Moji), Aleman, A. (André), Althoff, R.R. (Robert R.), Altmann, A. (A.), Andreassen, O.A. (Ole), Baron, D.A. (David A.), Bartnik-Olson, B.L. (Brenda L.), Marie Bas-Hoogendam, J. (Janna), Baskin-Sommers, A.R. (Arielle R.), Bearden, C.E. (Carrie), Berner, L.A. (Laura A.), Boedhoe, P.S.W. (Premika S W), Brouwer, R.M. (Rachel), Buitelaar, J.K. (Jan), Caeyenberghs, K. (Karen), Cecil, C.A.M. (Charlotte), Cohen, R.A. (Ronald A.), Cole, J.H. (James H.), Conrod, P. (Patricia), De Brito, S.A. (Stephane A.), de Zwarte, S.M.C. (Sonja M C), Dennis, E.L. (Emily L.), Desrivieres, S. (Sylvane), Dima, D. (Danai), Ehrlich, S.M. (Stefan), Esopenko, C. (Carrie), Fairchild, G. (Graeme), Fisher, S.E. (Simon), Fouche, J.-P. (Jean-Paul), Francks, C. (Clyde), Frangou, S. (Sophia), Franke, B. (Barbara), Garavan, H.P. (Hugh P.), Glahn, D.C. (David), Groenewold, N.A. (Nynke A.), Gurholt, T.P. (Tiril P.), Gutman, B.A. (Boris A.), Hahn, T. (Tim), Harding, I.H. (Ian H.), Hernaus, D. (Dennis), Hibar, D.P. (Derrek P.), Hillary, F.G. (Frank G.), Hoogman, M. (Martine), Hulshoff Pol, H.E. (Hilleke E.), Jalbrzikowski, M. (Maria), Karkashadze, G.A. (George A.), Klapwijk, E.T. (Eduard T.), Knickmeyer, R.C. (Rebecca C.), Kochunov, P. (Peter), Koerte, I.K. (Inga K.), Kong, X.-Z. (Xiang-Zhen), Liew, S.-L. (Sook-Lei), Lin, A.P. (Alexander P.), Logue, M.W. (Mark W.), Luders, E. (Eileen), Macciardi, F. (Fabio), Mackey, S. (Scott), Mayer, A.R. (Andrew R.), McDonald, C.R. (Carrie R.), McMahon, A.B. (Agnes B.), Medland, S.E. (Sarah), Modinos, G. (Gemma), Morey, R.A. (Rajendra A.), Mueller, S.C. (Sven C.), Mukherjee, P. (Pratik), Namazova-Baranova, L. (L.), Nir, T.M. (Talia M.), Olsen, A. (Alexander), Paschou, P. (Peristera), Pine, D.S. (Daniel S.), Pizzagalli, F. (Fabrizio), Rentería, M.E. (Miguel), Rohrer, J.D. (Jonathan D.), Sämann, P.G. (Philipp), Schmaal, L. (Lianne), Schumann, G. (Gunter), Shiroishi, M.S. (Mark S.), Sisodiya, S.M. (Sanjay), Smit, D.J.A. (Dirk J A), Sønderby, I.E. (Ida E.), Stein, D.J. (Dan J.), Stein, J.L., Tahmasian, M. (Masoud), Tate, D.F. (David F.), Turner, J. (Jessica), Heuvel, O.A. (Odile A.), Wee, N.J. (Nic) van der, van der Werf, Y.D. (Ysbrand), Erp, T.G.M. (Theo G.) van, van Haren, N.E.M. (Neeltje E M), van Rooij, D. (Daan), Van Velzen, L.S., Veer, I.M. (Ilya), Veltman, D.J. (Dick), Villalon-Reina, J.E. (Julio E.), Walter, H.J. (Henrik), Whelan, C.D. (Christopher), Wilde, E.A. (Elisabeth A.), Zarei, M. (Mojtaba), and Zelman, V. (Vladimir)

Abstract

This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development and aging; still other WGs develop methodological pipelines and tools to facilitate harmonized analyses of "big data" (i.e., genetic and epigenetic data, multimodal MRI, and electroencephalography data). These international efforts have yielded the largest neuroimaging studies to date in schizophrenia, bipolar disorder, major depressive disorder, post-traumatic stress disorder, substance use disorders, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism spectrum disorders, epilepsy, and 22q11.2 deletion syndrome. More recent ENIGMA WGs have formed to study anxiety disorders, suicidal thoughts and behavior, sleep and insomnia, eating disorders, irritability, brain injury, antisocial personality and conduct disorder, and dissociative identity disorder. Here, we summarize the first decade of ENIGMA's activities and ongoing projects, and describe the successes and challenges encountered along the way. We highlight the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings, offering the opportunity to identify brain systems involved in clinical syndromes across diverse samples and associated genetic, environmental, demographic, cognitive, and psychosocial factors.

Published
2020
Full Text
View/download PDF

14. Identification of neurobehavioural symptom groups based on shared brain mechanisms

Author

Ing, A., Samann, P.G., Chu, C., Tay, N., Biondo, F., Robert, G., Jia, T., Wolfers, T., Desrivieres, S., Banaschewski, T., Bokde, A.L., Bromberg, U., Buchel, C., Conrod, P., Fadai, T., Flor, H., Frouin, V., Garavan, H., Spechler, P.A., Gowland, P., Grimmer, Y., Heinz, A., Ittermann, B., Kappel, V., Martinot, J.L., Meyer-Lindenberg, A., Millenet, S., Nees, F., Noort, B. van, Orfanos, D.P., Martinot, M.P., Penttila, J., Poustka, L., Quinlan, E.B., Smolka, M.N., Stringaris, A., Struve, M., Veer, I.M., Walter, H., Whelan, R., Andreassen, O.A., Agartz, I., Lemaitre, H., Barker, E.D., Ashburner, J., Binder, E., Buitelaar, J.K., Marquand, A.F., Robbins, T.W, Schumann, G., Ing, A., Samann, P.G., Chu, C., Tay, N., Biondo, F., Robert, G., Jia, T., Wolfers, T., Desrivieres, S., Banaschewski, T., Bokde, A.L., Bromberg, U., Buchel, C., Conrod, P., Fadai, T., Flor, H., Frouin, V., Garavan, H., Spechler, P.A., Gowland, P., Grimmer, Y., Heinz, A., Ittermann, B., Kappel, V., Martinot, J.L., Meyer-Lindenberg, A., Millenet, S., Nees, F., Noort, B. van, Orfanos, D.P., Martinot, M.P., Penttila, J., Poustka, L., Quinlan, E.B., Smolka, M.N., Stringaris, A., Struve, M., Veer, I.M., Walter, H., Whelan, R., Andreassen, O.A., Agartz, I., Lemaitre, H., Barker, E.D., Ashburner, J., Binder, E., Buitelaar, J.K., Marquand, A.F., Robbins, T.W, and Schumann, G.

Abstract

Item does not contain fulltext, Most psychopathological disorders develop in adolescence. The biological basis for this development is poorly understood. To enhance diagnostic characterization and develop improved targeted interventions, it is critical to identify behavioural symptom groups that share neural substrates. We ran analyses to find relationships between behavioural symptoms and neuroimaging measures of brain structure and function in adolescence. We found two symptom groups, consisting of anxiety/depression and executive dysfunction symptoms, respectively, that correlated with distinct sets of brain regions and inter-regional connections, measured by structural and functional neuroimaging modalities. We found that the neural correlates of these symptom groups were present before behavioural symptoms had developed. These neural correlates showed case-control differences in corresponding psychiatric disorders, depression and attention deficit hyperactivity disorder in independent clinical samples. By characterizing behavioural symptom groups based on shared neural mechanisms, our results provide a framework for developing a classification system for psychiatric illness that is based on quantitative neurobehavioural measures.

Published
2019

15. Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group

Author

Schmaal, L. (L.), Hibar, D.P. (D. P.), Sämann, P.G. (Philipp), Hall, G.B. (Garry), Baune, B.T., Jahanshad, N. (Neda), Cheung, J.W. (J. W.), Erp, T.G.M. (Theo G.) van, Bos, D. (Daniel), Ikram, M.K. (Kamran), Vernooij, M.W. (Meike), Niessen, W.J. (Wiro), Tiemeier, H.W. (Henning), Hofman, A. (Albert), Wittfeld, K. (Katharina), Grabe, H.J. (Hans Jörgen), Janowitz, D. (Deborah), Bülow, R. (R.), Selonke, M. (M.), Völzke, H. (Henry), Grotegerd, D. (D.), Dannlowski, U. (U.), Arolt, V. (Volker), Opel, N. (N.), Heindel, W. (W.), Kugel, H. (H.), Hoehn, D. (David), Czisch, M. (Michael), Couvy-Duchesne, B. (Baptiste), Rentería, M.E. (Miguel), Strike, L.T. (Lachlan), Wright, M.J. (Margaret), Mills, N.T., Zubicaray, G.I. (Greig) de, Mcmahon, K.L. (Katie), Medland, S.E. (Sarah), Martin, N.G. (Nicholas), Gillespie, N.A. (N. A.), Goya-Maldonado, R., Gruber, O. (Oliver), Krämer, B.K. (Bernhard), Hatton, W., Lagopoulos, J. (Jim), Hickie, I.B. (Ian), Frodl, T. (Thomas), Carballedo, A., Frey, E.M., Van Velzen, L.S., Penninx, B.W.J.H. (Brenda), Tol, M.J.D. (Marie-José) van, Wee, N.J. (Nic) van der, Davey, C.G. (Christopher), Harrison, B.J. (B. J.), Mwangi, B. (Benson), Cao, B. (B.), Soares, J.C. (J. C.), Veer, I.M. (Ilya), Walter, H.J. (Henrik), Schoepf, D., Zurowski, B., Konrad, C. (C.), Schramm, E. (E.), Normann, C., Schnell, K. (Kerry), Sacchet, M.D. (M. D.), Gotlib, I.H. (I. H.), MacQueen, G.M. (Glenda), Godlewska, B. (Beata), Nickson, T., McIntosh, A.M. (Andrew), Papmeyer, M. (Martina), Whalley, H.C. (H. C.), Hall, J. (Jeremy), Sussmann, J. (Jessika), Li, M. (M.), Walter, M. (M.), Aftanas, L. (L.), Brack, I. (I.), Bokhan, N.A. (N. A.), Thompson, P.M. (Paul), Veltman, D.J. (Dick), Schmaal, L. (L.), Hibar, D.P. (D. P.), Sämann, P.G. (Philipp), Hall, G.B. (Garry), Baune, B.T., Jahanshad, N. (Neda), Cheung, J.W. (J. W.), Erp, T.G.M. (Theo G.) van, Bos, D. (Daniel), Ikram, M.K. (Kamran), Vernooij, M.W. (Meike), Niessen, W.J. (Wiro), Tiemeier, H.W. (Henning), Hofman, A. (Albert), Wittfeld, K. (Katharina), Grabe, H.J. (Hans Jörgen), Janowitz, D. (Deborah), Bülow, R. (R.), Selonke, M. (M.), Völzke, H. (Henry), Grotegerd, D. (D.), Dannlowski, U. (U.), Arolt, V. (Volker), Opel, N. (N.), Heindel, W. (W.), Kugel, H. (H.), Hoehn, D. (David), Czisch, M. (Michael), Couvy-Duchesne, B. (Baptiste), Rentería, M.E. (Miguel), Strike, L.T. (Lachlan), Wright, M.J. (Margaret), Mills, N.T., Zubicaray, G.I. (Greig) de, Mcmahon, K.L. (Katie), Medland, S.E. (Sarah), Martin, N.G. (Nicholas), Gillespie, N.A. (N. A.), Goya-Maldonado, R., Gruber, O. (Oliver), Krämer, B.K. (Bernhard), Hatton, W., Lagopoulos, J. (Jim), Hickie, I.B. (Ian), Frodl, T. (Thomas), Carballedo, A., Frey, E.M., Van Velzen, L.S., Penninx, B.W.J.H. (Brenda), Tol, M.J.D. (Marie-José) van, Wee, N.J. (Nic) van der, Davey, C.G. (Christopher), Harrison, B.J. (B. J.), Mwangi, B. (Benson), Cao, B. (B.), Soares, J.C. (J. C.), Veer, I.M. (Ilya), Walter, H.J. (Henrik), Schoepf, D., Zurowski, B., Konrad, C. (C.), Schramm, E. (E.), Normann, C., Schnell, K. (Kerry), Sacchet, M.D. (M. D.), Gotlib, I.H. (I. H.), MacQueen, G.M. (Glenda), Godlewska, B. (Beata), Nickson, T., McIntosh, A.M. (Andrew), Papmeyer, M. (Martina), Whalley, H.C. (H. C.), Hall, J. (Jeremy), Sussmann, J. (Jessika), Li, M. (M.), Walter, M. (M.), Aftanas, L. (L.), Brack, I. (I.), Bokhan, N.A. (N. A.), Thompson, P.M. (Paul), and Veltman, D.J. (Dick)

Abstract

The neuro-anatomical substrates of major depressive disorder (MDD) are still not well understood, despite many neuroimaging studies over the past few decades. Here we present the largest ever worldwide study by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Major Depressive Disorder Working Group on cortical structural alterations in MDD. Structural T1-weighted brain magnetic resonance imaging (MRI) scans from 2148 MDD patients and 7957 healthy controls were analysed with harmonized protocols at 20 sites around the world. To detect consistent effects of MDD and its modulators on cortical thickness and surface area estimates derived from MRI, statistical effects from sites were meta-analysed separately for adults and adolescents. Adults with MDD had thinner cortical gray matter than controls in the orbitofrontal cortex (OFC), anterior and posterior cingulate, insula and temporal lobes (Cohen's d effect sizes: -0.10 to -0.14). These effects were most pronounced in first episode and adult-onset patients (>21 years). Compared to matched controls, adolescents with MDD had lower total surface area (but no differences in cortical thickness) and regional reductions in frontal regions (medial OFC and superior frontal gyrus) and primary and higher-order visual, somatosensory and motor areas (d: -0.26 to -0.57). The strongest effects were found in recurrent adolescent patients. This highly powered global effort to identify consistent brain abnormalities showed widespread cortical alterations in MDD patients as compared to controls and suggests that MDD may impact brain structure in a highly dynamic way, with different patterns of alterations at different stages of life.

Published
2017
Full Text
View/download PDF

16. The resilience framework as a strategy to combat stress-related disorders

Author

Kalisch, R., Baker, D.G., Basten, U., Boks, M.P.M., Bonanno, G.A., Brummelman, E., Chmitorz, A., Fernandez, G.S.E., Fiebach, C.J., Galatzer-Levy, I.R., Geuze, E., Groppa, S., Helmreich, I., Hendler, T., Hermans, E.J., Jovanovic, T., Kubiak, T., Lieb, K., Lutz, B., Müller, M.B., Murray, R.J., Nievergelt, C.M., Reif, A., Roelofs, K., Rutten, B.P.F., Sander, D., Schick, A., Tüscher, O., Diest, I. van, Harmelen, A.L. van, Veer, I.M., Vermetten, E., Vinkers, C.H., Wager, T.D., Walter, H., Wessa, M., Wibral, M., Kleim, B., Kalisch, R., Baker, D.G., Basten, U., Boks, M.P.M., Bonanno, G.A., Brummelman, E., Chmitorz, A., Fernandez, G.S.E., Fiebach, C.J., Galatzer-Levy, I.R., Geuze, E., Groppa, S., Helmreich, I., Hendler, T., Hermans, E.J., Jovanovic, T., Kubiak, T., Lieb, K., Lutz, B., Müller, M.B., Murray, R.J., Nievergelt, C.M., Reif, A., Roelofs, K., Rutten, B.P.F., Sander, D., Schick, A., Tüscher, O., Diest, I. van, Harmelen, A.L. van, Veer, I.M., Vermetten, E., Vinkers, C.H., Wager, T.D., Walter, H., Wessa, M., Wibral, M., and Kleim, B.

Abstract

Item does not contain fulltext, Consistent failure over the past few decades to reduce the high prevalence of stress-related disorders has motivated a search for alternative research strategies. Resilience refers to the phenomenon of many people maintaining mental health despite exposure to psychological or physical adversity. Instead of aiming to understand the pathophysiology of stress-related disorders, resilience research focuses on protective mechanisms that shield people against the development of such disorders and tries to exploit its insights to improve treatment and, in particular, disease prevention. To fully harness the potential of resilience research, a critical appraisal of the current state of the art - in terms of basic concepts and key methods - is needed. We highlight challenges to resilience research and make concrete conceptual and methodological proposals to improve resilience research. Most importantly, we propose to focus research on the dynamic processes of successful adaptation to stressors in prospective longitudinal studies.

Published
2017

17. Dissociable relations between amygdala subregional networks and psychopathy trait dimensions in conduct-disordered juvenile offenders

Author

Aghajani, M., Colins, O.F., Klapwijk, E.T., Veer, I.M., Andershed, H., Popma, A., Van der Wee, N.J., Vermeiren, R.J.M., Andershed, H. Popma A., Van, der Wee N.J., Pediatric surgery, EMGO - Mental health, Andershed, H. Popma A., and Van, der Wee N.J.

Subjects
Male, Adolescent, Substance-Related Disorders, Rest, Psychopathy, Poison control, Comorbidity, Brain mapping, Amygdala, 050105 experimental psychology, psychopathy, Developmental psychology, 03 medical and health sciences, 0302 clinical medicine, Interview, Psychological, Neural Pathways, medicine, Humans, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, Big Five personality traits, Research Articles, Brain Mapping, Radiological and Ultrasound Technology, Salience (language), conduct disorder, Antisocial personality disorder, 05 social sciences, Antisocial Personality Disorder, amygdala, Criminals, medicine.disease, Magnetic Resonance Imaging, medicine.anatomical_structure, Neurology, Conduct disorder, Neurology (clinical), Anatomy, Psychology, intrinsic functional connectivity, 030217 neurology & neurosurgery, Research Article
Abstract

Psychopathy is a serious psychiatric phenomenon characterized by a pathological constellation of affective (e.g., callous, unemotional), interpersonal (e.g., manipulative, egocentric), and behavioral (e.g., impulsive, irresponsible) personality traits. Though amygdala subregional defects are suggested in psychopathy, the functionality and connectivity of different amygdala subnuclei is typically disregarded in neurocircuit‐level analyses of psychopathic personality. Hence, little is known of how amygdala subregional networks may contribute to psychopathy and its underlying trait assemblies in severely antisocial people. We addressed this important issue by uniquely examining the intrinsic functional connectivity of basolateral (BLA) and centromedial (CMA) amygdala networks in relation to affective, interpersonal, and behavioral traits of psychopathy, in conduct‐disordered juveniles with a history of serious delinquency (N = 50, mean age = 16.83 ± 1.32). As predicted, amygdalar connectivity profiles exhibited dissociable relations with different traits of psychopathy. Interpersonal psychopathic traits not only related to increased connectivity of BLA and CMA with a corticostriatal network formation accommodating reward processing, but also predicted stronger CMA connectivity with a network of cortical midline structures supporting sociocognitive processes. In contrast, affective psychopathic traits related to diminished CMA connectivity with a frontolimbic network serving salience processing and affective responding. Finally, behavioral psychopathic traits related to heightened BLA connectivity with a frontoparietal cluster implicated in regulatory executive functioning. We suggest that these trait‐specific shifts in amygdalar connectivity could be particularly relevant to the psychopathic phenotype, as they may fuel a self‐centered, emotionally cold, and behaviorally disinhibited profile. Hum Brain Mapp 37:4017–4033, 2016. © 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.

Published
2016

18. Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group

Author

Schmaal, L., Veltman, D.J., Erp, T.G.M. van, Samann, P.G., Frodl, T., Jahanshad, N., Loehrer, E., Tiemeier, H., Hofman, A., Niessen, W.J., Vernooij, M.W., Ikram, M.A., Wittfeld, K., Grabe, H.J., Block, A., Hegenscheid, K., Volzke, H., Hoehn, D., Czisch, M., Lagopoulos, J., Hatton, S.N., Hickie, I.B., Goya-Maldonado, R., Kramer, B., Gruber, O., Couvy-Duchesne, B., Renteria, M.E., Strike, L.T., Mills, N.T., Zubicaray, G.I. de, McMahon, K.L., Medland, S.E., Martin, N.G., Gillespie, N.A., Wright, M.J., Hall, G.B., MacQueen, G.M., Frey, E.M., Carballedo, A., Velzen, L.S. van, Tol, M.J. van, Wee, N.J. van der, Veer, I.M., Walter, H., Schnell, K., Schramm, E., Normann, C., Schoepf, D., Konrad, C., Zurowski, B., Nickson, T., McIntosh, A.M., Papmeyer, M., Whalley, H.C., Sussmann, J.E., Godlewska, B.R., Cowen, P.J., Fischer, F.H., Rose, M., Penninx, B.W.J.H., Thompson, P.M., Hibar, D.P., ENIGMA-Major Depressive Disorder W, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Clinical Cognitive Neuropsychiatry Research Program (CCNP), Psychiatry, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Anatomy and neurosciences, Epidemiology, Medical Informatics, Radiology & Nuclear Medicine, Neurology, and Erasmus MC other

Subjects
Male, STRESS, hippocampus, SEGMENTATION, Hippocampus, UNIPOLAR DEPRESSION, Medical and Health Sciences, Lateral ventricles, 0302 clinical medicine, pathology [Brain], 2.1 Biological and endogenous factors, Aetiology, Letter to the Editor, First episode, Psychiatry, pathology [Depressive Disorder, Major], ENIGMA consortium, ABNORMALITIES, Depression, Brain, Middle Aged, Biological Sciences, Serious Mental Illness, Magnetic Resonance Imaging, 3. Good health, AMYGDALA VOLUME, Psychiatry and Mental health, structural volumes, Mental Health, VOXEL-BASED MORPHOMETRY, Neurological, Cardiology, Major depressive disorder, Biomedical Imaging, ONSET DEPRESSION, Original Article, Female, Psychology, methods [Neuroimaging], Clinical psychology, Adult, medicine.medical_specialty, Major Depressive Disorder, HIPPOCAMPAL VOLUME, Neuroimaging, behavioral disciplines and activities, 03 medical and health sciences, Cellular and Molecular Neuroscience, Clinical Research, Internal medicine, medicine, Subcortical brain alterations, depressive disorder, ENIGMA, Humans, Bipolar disorder, ddc:610, Molecular Biology, METAANALYSIS, Depressive Disorder, Major, Depressive Disorder, Brain morphometry, Psychology and Cognitive Sciences, Neurosciences, Major, Voxel-based morphometry, medicine.disease, 030227 psychiatry, Brain Disorders, meta-analysis, pathology [Hippocampus], Case-Control Studies, Age of onset, MATTER, 030217 neurology & neurosurgery
Abstract

The pattern of structural brain alterations associated with major depressive disorder (MDD) remains unresolved. This is in part due to small sample sizes of neuroimaging studies resulting in limited statistical power, disease heterogeneity and the complex interactions between clinical characteristics and brain morphology. To address this, we meta-analyzed three-dimensional brain magnetic resonance imaging data from 1728 MDD patients and 7199 controls from 15 research samples worldwide, to identify subcortical brain volumes that robustly discriminate MDD patients from healthy controls. Relative to controls, patients had significantly lower hippocampal volumes (Cohen's d=-0.14, % difference=-1.24). This effect was driven by patients with recurrent MDD (Cohen's d=-0.17, % difference=-1.44), and we detected no differences between first episode patients and controls. Age of onset ⩽21 was associated with a smaller hippocampus (Cohen's d=-0.20, % difference=-1.85) and a trend toward smaller amygdala (Cohen's d=-0.11, % difference=-1.23) and larger lateral ventricles (Cohen's d=0.12, % difference=5.11). Symptom severity at study inclusion was not associated with any regional brain volumes. Sample characteristics such as mean age, proportion of antidepressant users and proportion of remitted patients, and methodological characteristics did not significantly moderate alterations in brain volumes in MDD. Samples with a higher proportion of antipsychotic medication users showed larger caudate volumes in MDD patients compared with controls. This currently largest worldwide effort to identify subcortical brain alterations showed robust smaller hippocampal volumes in MDD patients, moderated by age of onset and first episode versus recurrent episode status.Molecular Psychiatry advance online publication, 30 June 2015; doi:10.1038/mp.2015.69. peerReviewed

Published
2016

19. VVE helpt 2: Startgroepen

Author

Veer, I.M. (Ilona), Vegt, van der, A.L. (Anne Luc), Tuijl, van, C. (Cathy), and Sleegers, P. (Peter)

Subjects
startgroepen, VVE, opbrengst gericht werken, doelgroepkinderen
Abstract

Zijn startgroepen effectief in het kleiner maken van (taal)achterstanden bij kinderen? Ja, blijkt uit onderzoek door de Universiteit Twente en Oberon. Met veel uren (12,5 per week), een pabo-geschoolde leerkracht, nadruk op opbrengstgericht werken, een doorgaande leerlijn en onder regie van de basisschool kunnen doelgroepkinderen geholpen worden.

Published
2016

20. Structural brain alterations in major depression: findings from the ENIGMA Major Depressive Disorder Working Group

Author

Schmaal, L., Veltman, D.J., Erp, T.G. van, Samann, P.G., Frodl, T., Jahanshad, N., Loehrer, E., Tiemeier, H., Hofman, A., Niessen, W.J., Vernooij, M.W., Ikram, M.A., Wittfeld, K., Grabe, H.J., Block, A., Hegenscheid, K., Volzke, H., Hoehn, D., Czisch, M., Lagopoulos, J., Hatton, S.N., Hickie, I.B., Goya-Maldonado, R., Kramer, B., Gruber, O., Couvy-Duchesne, B., Renteria, M.E., Strike, L.T., Mills, N.T., Zubicaray, G.I. de, McMahon, K.L., Medland, S.E., Martin, N.G., Gillespie, N.A., Wright, M.J., Hall, G.B., MacQueen, G.M., Frey, E.M., Carballedo, A., Velzen, L.S. van, Tol, M.J. van, Wee, N.J. van der, Veer, I.M., Walter, H., Schnell, K., Schramm, E., Normann, C., Schoepf, D., Konrad, C., Zurowski, B., Nickson, T., McIntosh, A.M., Papmeyer, M., Whalley, H.C., Sussmann, J.E., Godlewska, B.R., Cowen, P.J., Fischer, F.H., Rose, M., Penninx, B.W., Thompson, P.M., Hibar, D.P., and ENIGMA-Major Depressive Disorder W

Published
2015

21. The stress connection: Neuroimaging studies of emotion circuits in social stress, personality, and stress-related psychopathology

Author

Veer, I.M., Rombouts, S.A.R.B., Buchem, M.A. van, Elzinga, B.M., Wee, N.J. van der, Meijer, O.C., Beckmann, C.F., Fernandez, G., Johstone, I.T., and Leiden University

Subjects
Emotion, Resting-state, Functional connectivity, fMRI, Major depression, PTSD, Amygdala, Stress
Abstract

The aim of this thesis was to identify the neural mechanisms that enable a person to adaptively respond to, and recover from stress, which was studied in healthy controls, in people with increased vulnerability or resilience to stress-related disorders, and in people with depression or PTSD, using magnetic resonance imaging (MRI). In most of the studies, a specific MRI method was employed, with which it is possible to assess how different brain regions communicate with each other (i.e., functional connectivity) when the brain is initiating or regulating stress responses. Structure, activity, and connectivity of the amygdala, a small brain region important for stress reactivity, was of main interest. The results show how stress influences information processing, and causes changes in the communication between brain areas, even long after the stressful event ended. Furthermore, personality dimensions associated with increased vulnerability or resilience to affective disorders were associated with changes in brain networks involved in emotion processing and regulation. Finally, smaller amygdala volumes were found in women with PTSD, while reduced integrity of affective brain networks was demonstrated in depression. Together, these results open important new avenues for future research into the short and long term effects of stress on the brain.

Published
2015

22. Cerebral volumetric abnormalities in Neurofibromatosis type 1: associations with parent ratings of social and attention problems, executive dysfunction, and autistic mannerisms

Author

Huijbregts, S.C.J., Loitfelder, M., Rombouts, S.A., Swaab, H., Verbist, B.M., Arkink, E.B., Buchem, M.A. van, and Veer, I.M.

Subjects
Subcortical volume, Magnetic resonance imaging, Executive and social functioning, Voxel-based morphometry, Gray matter, Neurofibromatosis type 1, Rare cancers Radboud Institute for Health Sciences [Radboudumc 9]
Abstract

Contains fulltext : 154738.pdf (Publisher’s version ) (Open Access) Neurofibromatosis type 1 (NF1) is a single-gene neurodevelopmental disorder, in which social and cognitive problems are highly prevalent. Several commonly observed central nervous system (CNS) abnormalities in NF1 might underlie these social and cognitive problems. Cerebral volumetric abnormalities are among the most consistently observed CNS abnormalities in NF1. This study investigated whether differences were present between NF1 patients and healthy controls (HC) in volumetric measures of cortical and subcortical brain regions and whether differential associations existed for NF1 patients and HC between the volumetric measures and parent ratings of social skills, attention problems, social problems, autistic mannerisms, and executive dysfunction.Fifteen NF1 patients (mean age 12.9 years, SD 2.6) and 18 healthy controls (HC, mean age 13.8 years, SD 3.6) underwent 3 T MRI scanning. Segmentation of cortical gray and white matter, as well as volumetry of subcortical nuclei, was carried out. Voxel-based morphometry was performed to assess cortical gray matter density. Correlations were calculated, for NF1-patients and HC separately, between MRI parameters and scores on selected dimensions of the following behavior rating scales: the Social Skills Rating System, the Child Behavior Checklist, the Social Responsiveness Scale, the Behavior Rating Inventory of Executive Functioning, and the Dysexecutive Questionnaire.After correction for age, sex, and intracranial volume, larger volumes of all subcortical regions were found in NF1 patients compared to controls. Patients further showed decreased gray matter density in midline regions of the frontal and parietal lobes and larger total white matter volume. Significantly more social and attention problems, more autistic mannerisms, and poorer executive functioning were reported for NF1 patients compared to HC. In NF1 patients, larger left putamen volume and larger total white matter volume were associated with more social problems and poorer executive functioning, larger right amygdala volume with poorer executive functioning and autistic mannerisms, and smaller precentral gyrus gray matter density was associated with more social problems. In controls, only significant negative correlations were observed: larger volumes (and greater gray matter density) were associated with better outcomes.Widespread volumetric differences between patients and controls were found in cortical and subcortical brain regions. In NF1 patients but not HC, larger volumes were associated with poorer behavior ratings.

Published
2015

25. Response to Dr Fried & Dr Kievit, and Dr Malhi et al.

Author

Schmaal, L. (Lianne), Veltman, D.J. (Dick), Van Erp, T.G.M., Smann, P.G., Frodl, T. (Thomas), Jahanshad, N., Loehrer, E. (Elizabeth), Vernooij, M.W. (Meike), Niessen, W.J. (Wiro), Ikram, M.A. (Arfan), Wittfeld, K., Grabe, H.J. (Hans Jörgen), Block, A. (Andrea), Hegenscheid, K. (Katrin), Hoehn, D. (David), Czisch, M. (Michael), Lagopoulos, J. (Jim), Hatton, W., Hickie, I.B. (Ian), Goya-Maldonado, R., Krmer, B., Gruber, O., Couvy-Duchesne, B. (Baptiste), Rentera, M.E., Strike, L.T. (Lachlan), Wright, M.J., Zubicaray, G.I. (Greig) de, McMahon, K.L., Medland, S.E. (Sarah), Gillespie, N.A., Hall, G.B., Van Velzen, L.S., Tol, M.J.D. (Marie-José) van, Wee, N.J. (Nic) van der, Veer, I.M. (Ilya), Walter, H., Schramm, E., Normann, C., Schoepf, D., Konrad, C., Zurowski, B., McIntosh, A.M., Whalley, H.C., Sussmann, J. (Jessika), Godlewska, B. (Beata), Fischer, F.H., Penninx, B.W.J.H., Thompson, P.M., Hibar, D.P. (Derrek), Schmaal, L. (Lianne), Veltman, D.J. (Dick), Van Erp, T.G.M., Smann, P.G., Frodl, T. (Thomas), Jahanshad, N., Loehrer, E. (Elizabeth), Vernooij, M.W. (Meike), Niessen, W.J. (Wiro), Ikram, M.A. (Arfan), Wittfeld, K., Grabe, H.J. (Hans Jörgen), Block, A. (Andrea), Hegenscheid, K. (Katrin), Hoehn, D. (David), Czisch, M. (Michael), Lagopoulos, J. (Jim), Hatton, W., Hickie, I.B. (Ian), Goya-Maldonado, R., Krmer, B., Gruber, O., Couvy-Duchesne, B. (Baptiste), Rentera, M.E., Strike, L.T. (Lachlan), Wright, M.J., Zubicaray, G.I. (Greig) de, McMahon, K.L., Medland, S.E. (Sarah), Gillespie, N.A., Hall, G.B., Van Velzen, L.S., Tol, M.J.D. (Marie-José) van, Wee, N.J. (Nic) van der, Veer, I.M. (Ilya), Walter, H., Schramm, E., Normann, C., Schoepf, D., Konrad, C., Zurowski, B., McIntosh, A.M., Whalley, H.C., Sussmann, J. (Jessika), Godlewska, B. (Beata), Fischer, F.H., Penninx, B.W.J.H., Thompson, P.M., and Hibar, D.P. (Derrek)

Published
2016
Full Text
View/download PDF

26. Subcortical brain alterations in major depressive disorder: Findings from the ENIGMA Major Depressive Disorder working group

Author

Schmaal, L. (Lianne), Veltman, D.J. (Dick), Van Erp, T.G.M., Smann, P.G., Frodl, T. (Thomas), Jahanshad, N., Loehrer, E. (Elizabeth), Tiemeier, H.W. (Henning), Hofman, A., Niessen, W.J. (Wiro), Vernooij, M.W. (Meike), Ikram, M.A. (Arfan), Wittfeld, K. (Katharina), Grabe, H.J. (Hans Jörgen), Block, A. (Andrea), Hegenscheid, K. (Katrin), Völzke, H. (Henry), Hoehn, D. (David), Czisch, M. (Michael), Lagopoulos, J. (Jim), Hatton, W., Hickie, I.B. (Ian), Goya-Maldonado, R., Krmer, B., Gruber, O., Couvy-Duchesne, B. (Baptiste), Rentera, M.E., Strike, L.T. (Lachlan), Mills, N.T., Zubicaray, G.I. (Greig) de, Mcmahon, K.L. (Katie), Medland, S.E. (Sarah), Martin, N.G. (Nicholas), Gillespie, N.A., Wright, M.J. (Margaret), Hall, G.B., MacQueen, G.M. (Glenda), Frey, E.M., Carballedo, A., Van Velzen, L.S., Tol, M.J.D. (Marie-José) van, Wee, N.J. (Nic) van der, Veer, I.M. (Ilya), Walter, H., Schnell, K., Schramm, E., Normann, C., Schoepf, D., Konrad, C., Zurowski, B., Nickson, T., McIntosh, A.M. (Andrew), Papmeyer, M. (Martina), Whalley, H.C., Sussmann, J. (Jessika), Godlewska, B. (Beata), Cowen, P.J., Fischer, F.H., Rose, M., Penninx, B.W.J.H. (Brenda), Thompson, P.M., Hibar, D.P. (Derrek), Schmaal, L. (Lianne), Veltman, D.J. (Dick), Van Erp, T.G.M., Smann, P.G., Frodl, T. (Thomas), Jahanshad, N., Loehrer, E. (Elizabeth), Tiemeier, H.W. (Henning), Hofman, A., Niessen, W.J. (Wiro), Vernooij, M.W. (Meike), Ikram, M.A. (Arfan), Wittfeld, K. (Katharina), Grabe, H.J. (Hans Jörgen), Block, A. (Andrea), Hegenscheid, K. (Katrin), Völzke, H. (Henry), Hoehn, D. (David), Czisch, M. (Michael), Lagopoulos, J. (Jim), Hatton, W., Hickie, I.B. (Ian), Goya-Maldonado, R., Krmer, B., Gruber, O., Couvy-Duchesne, B. (Baptiste), Rentera, M.E., Strike, L.T. (Lachlan), Mills, N.T., Zubicaray, G.I. (Greig) de, Mcmahon, K.L. (Katie), Medland, S.E. (Sarah), Martin, N.G. (Nicholas), Gillespie, N.A., Wright, M.J. (Margaret), Hall, G.B., MacQueen, G.M. (Glenda), Frey, E.M., Carballedo, A., Van Velzen, L.S., Tol, M.J.D. (Marie-José) van, Wee, N.J. (Nic) van der, Veer, I.M. (Ilya), Walter, H., Schnell, K., Schramm, E., Normann, C., Schoepf, D., Konrad, C., Zurowski, B., Nickson, T., McIntosh, A.M. (Andrew), Papmeyer, M. (Martina), Whalley, H.C., Sussmann, J. (Jessika), Godlewska, B. (Beata), Cowen, P.J., Fischer, F.H., Rose, M., Penninx, B.W.J.H. (Brenda), Thompson, P.M., and Hibar, D.P. (Derrek)

Abstract

The pattern of structural brain alterations associated with major depressive disorder (MDD) remains unresolved. This is in part due to small sample sizes of neuroimaging studies resulting in limited statistical power, disease heterogeneity and the complex interactions between clinical characteristics and brain morphology. To address this, we meta-analyzed three-dimensional brain magnetic resonance imaging data from 1728 MDD patients and 7199 controls from 15 research samples worldwide, to identify subcortical brain volumes that robustly discriminate MDD patients from healthy controls. Relative to controls, patients had significantly lower hippocampal volumes (Cohen's d=-0.14, % difference=-1.24). This effect was driven by patients with recurrent MDD (Cohen's d=-0.17, % difference=-1.44), and we detected no differences between first episode patients and controls. Age of onset ≤21 was associated with a smaller hippocampus (Cohen's d=-0.20, % difference=-1.85) and a trend toward smaller amygdala (Cohen's d=-0.11, % difference=-1.23) and larger lateral ventricles (Cohen's d=0.12, % difference=5.11). Symptom severity at study inclusion was not associated with any regional brain volumes. Sample characteristics such as mean age, proportion of antidepressant users and proportion of remitted patients, and methodological characteristics did not significantly moderate alterations in brain volumes in MDD. Samples with a higher proportion of antipsychotic medication users showed larger caudate volumes in MDD patients compared with controls. This currently largest worldwide effort to identify subcortical brain alterations showed robust smaller hippocampal volumes in MDD patients, moderated by age of onset and first episode versus recurrent episode status.

Published
2016
Full Text
View/download PDF

31. Neural sensitivity to social reward and punishment anticipation in social anxiety disorder

Author

Cremers, H.R., Veer, I.M., Spinhoven, P., Rombouts, S.A.R.B., Roelofs, K., Cremers, H.R., Veer, I.M., Spinhoven, P., Rombouts, S.A.R.B., and Roelofs, K.

Abstract

Contains fulltext : 138659.pdf (publisher's version ) (Open Access), An imbalance in the neural motivational system may underlie Social Anxiety Disorder (SAD). This study examines social reward and punishment anticipation in SAD, predicting a valence-specific effect: increased striatal activity for punishment avoidance compared to obtaining a reward. Individuals with SAD (n = 20) and age, gender, and education case-matched controls (n = 20) participated in a functional magnetic resonance imaging (fMRI) study. During fMRI scanning, participants performed a Social Incentive Delay (SID) task to measure the anticipation of social reward and punishment. The left putamen (part of the striatum) showed a valence-specific interaction with group after correcting for medication use and comorbidity. The control group showed a relatively stronger activation for reward vs. punishment trials, compared to the social anxiety group. However, post-hoc pairwise comparisons were not significant, indicating that the effect is driven by a relative difference. A connectivity analysis (Psychophysiological interaction) further revealed a general salience effect: SAD patients showed decreased putamen-ACC connectivity compared to controls for both reward and punishment trials. Together these results suggest that the usual motivational preference for social reward is absent in SAD. In addition, cortical control processes during social incentive anticipation may be disrupted in SAD. These results provide initial evidence for altered striatal involvement in both valence-specific and valence-nonspecific processing of social incentives, and stress the relevance of taking motivational processes into account when studying social anxiety.

Published
2015

32. Altered cortical-amygdala coupling in social anxiety disorder during the anticipation of giving a public speech

Author

Cremers, H.R., Veer, I.M., Spinhoven, P., Rombouts, S.A.R.B., Yarkoni, T., Wager, T.D., Roelofs, K., Cremers, H.R., Veer, I.M., Spinhoven, P., Rombouts, S.A.R.B., Yarkoni, T., Wager, T.D., and Roelofs, K.

Abstract

Item does not contain fulltext, Background. Severe stress in social situations is a core symptom of social anxiety disorder (SAD). Connectivity between the amygdala and cortical regions is thought to be important for emotion regulation, a function that is compromised in SAD. However, it has never been tested if and how this connectivity pattern changes under conditions of stress-inducing social evaluative threat. Here we investigate changes in cortical-amygdala coupling in SAD during the anticipation of giving a public speech. Method. Twenty individuals with SAD and age-, gender-and education-matched controls (n = 20) participated in this study. During the functional magnetic resonance imaging (fMRI) session, participants underwent three 'resting-state' fMRI scans: one before, one during, and one after the anticipation of giving a public speech. Functional connectivity between cortical emotion regulation regions and the amygdala was investigated. Results. Compared to controls, SAD participants showed reduced functional integration between cortical emotion regulation regions and the amygdala during the public speech anticipation. Moreover, in SAD participants cortical-amygdala connectivity changes correlated with social anxiety symptom severity. Conclusions. The distinctive pattern of cortical-amygdala connectivity suggests less effective cortical-subcortical communication during social stress-provoking situations in SAD.

Published
2015

33. Cerebral volumetric abnormalities in Neurofibromatosis type 1: associations with parent ratings of social and attention problems, executive dysfunction, and autistic mannerisms

Author

Huijbregts, S.C., Loitfelder, M., Rombouts, S.A.R.B., Swaab, H., Verbist, B.M., Arkink, E.B., Buchem, M.A. van, Veer, I.M., Huijbregts, S.C., Loitfelder, M., Rombouts, S.A.R.B., Swaab, H., Verbist, B.M., Arkink, E.B., Buchem, M.A. van, and Veer, I.M.

Abstract

Contains fulltext : 154738.pdf (publisher's version ) (Open Access), Neurofibromatosis type 1 (NF1) is a single-gene neurodevelopmental disorder, in which social and cognitive problems are highly prevalent. Several commonly observed central nervous system (CNS) abnormalities in NF1 might underlie these social and cognitive problems. Cerebral volumetric abnormalities are among the most consistently observed CNS abnormalities in NF1. This study investigated whether differences were present between NF1 patients and healthy controls (HC) in volumetric measures of cortical and subcortical brain regions and whether differential associations existed for NF1 patients and HC between the volumetric measures and parent ratings of social skills, attention problems, social problems, autistic mannerisms, and executive dysfunction.Fifteen NF1 patients (mean age 12.9 years, SD 2.6) and 18 healthy controls (HC, mean age 13.8 years, SD 3.6) underwent 3 T MRI scanning. Segmentation of cortical gray and white matter, as well as volumetry of subcortical nuclei, was carried out. Voxel-based morphometry was performed to assess cortical gray matter density. Correlations were calculated, for NF1-patients and HC separately, between MRI parameters and scores on selected dimensions of the following behavior rating scales: the Social Skills Rating System, the Child Behavior Checklist, the Social Responsiveness Scale, the Behavior Rating Inventory of Executive Functioning, and the Dysexecutive Questionnaire.After correction for age, sex, and intracranial volume, larger volumes of all subcortical regions were found in NF1 patients compared to controls. Patients further showed decreased gray matter density in midline regions of the frontal and parietal lobes and larger total white matter volume. Significantly more social and attention problems, more autistic mannerisms, and poorer executive functioning were reported for NF1 patients compared to HC. In NF1 patients, larger left putamen volume and larger total white matter volume were associated with more social prob

Published
2015

34. Tract-Based Spatial Statistics on Diffusion Tensor Imaging in Systemic Lupus Erythematosus Reveals Localized Involvement of White Matter Tracts

Author

Emmer, B.J., Veer, I.M., Steup-Beekman, G.M., Huizinga, T.W.J., Grond, J. van der, and Buchem, M.A. van

Subjects
magnetization-transfer brain-injury antibody lesions abnormalities immunity criteria markers damage gray
Abstract

Objective. The aim of this study was to determine whether there are differences in white matter integrity between systemic lupus erythematosus (SLE) patients and healthy controls, as determined using tract-based spatial statistics (TBSS) analysis of diffusion tensor imaging data. Methods. Twelve patients with SLE (mean age 42 years [range 15-61 years]) diagnosed according to the American College of Rheumatology 1982 revised criteria for SLE and 28 healthy controls (mean age 46 years [range 21-61 years]) were included in the study. Magnetic resonance imaging was performed on a 3.0T scanner. Fractional anisotropy (FA) maps were calculated for each patient. TBSS analysis was used to compare the FA maps. The TBSS technique projects the FA data into a common space through the use of an initial approximate nonlinear registration, followed by projection onto an alignment-invariant tract representation (mean FA skeleton). The cluster results were corrected for multiple comparisons across space, and a threshold of significance of 0.05 was used. Results. The white matter of tracts in the inferior fronto-occipital fasciculus, the fasciculus uncinatus, as well as the fornix, the posterior limb of the internal capsule (corticospinal tract), and the anterior limb of the internal capsule (anterior thalamic radiation) of patients with SLE showed reduced integrity as compared with normal subjects. Conclusion. In this preliminary study, the integrity of white matter tracts in areas around limbic structures and in the internal capsule was found to be reduced. Larger studies could improve our understanding of the pathologic mechanisms behind the reduced white matter tract integrity in SLE.

Published
2010

35. P.2.b.017 Structural brain alterations in major depression: findings from the ENIGMA Major Depressive Disorder Working Group

Author

Schmaal, L., primary, Veltman, D.J, additional, Van Erp, T.G, additional, Sämann, P.G, additional, Frodl, T., additional, Jahanshad, N., additional, Loehrer, E., additional, Tiemeier, H., additional, Hofman, A., additional, Niessen, W.J, additional, Vernooij, M.W, additional, Ikram, M.A, additional, Wittfeld, K., additional, Grabe, H.J., additional, Block, A., additional, Hegenscheid, K., additional, Völzke, H., additional, Hoehn, D., additional, Czisch, M., additional, Lagopoulos, J., additional, Hatton, S.N, additional, Hickie, I.B., additional, Goya-Maldonado, R., additional, Krämer, B., additional, Gruber, O., additional, Couvy-Duchesne, B., additional, Rentería, M.E, additional, Strike, L.T, additional, Mills, N.T, additional, De Zubicaray, G.I, additional, McMahon, K.L, additional, Medland, S.E., additional, Martin, N.G, additional, Gillespie, N.A, additional, Wright, M.J, additional, Hall, G.B, additional, MacQueen, G.M, additional, Frey, E.M, additional, Carballedo, A., additional, Van Velzen, L.S., additional, Van Tol, M.J, additional, Van der Wee, N.J, additional, Veer, I.M., additional, Walter, H., additional, Schnell, K., additional, Schramm, E., additional, Normann, C., additional, Schoepf, D., additional, Konrad, C., additional, Zurowski, B., additional, Nickson, T., additional, McIntosh, A.M, additional, Papmeyer, M., additional, Whalley, H.C, additional, Sussmann, J.E, additional, Godlewska, B.R, additional, Cowen, P.J, additional, Fischer, F.H, additional, Rose, M., additional, Penninx, B.W, additional, Thompson, P.M, additional, and Hibar, D.P, additional

Published
2015
Full Text
View/download PDF

37. Structural and functional brain connectivity in presymptomatic familial frontotemporal dementia

Author

Dopper, E.G.P. (Elise), Rombouts, S.A.R.B. (Serge), Jiskoot, L.C. (Lize), Heijer, T. (Tom) den, Graaf, J.R.A. (Joke) de, Koning, I. (Inge) de, Hammerschlag, M.R., Seelaar, H. (Harro), Seeley, W. (William), Veer, I.M. (Ilya), Buchem, M.A. (Mark) van, Rizzu, P. (Patrizia), Swieten, J.C. (John) van, Dopper, E.G.P. (Elise), Rombouts, S.A.R.B. (Serge), Jiskoot, L.C. (Lize), Heijer, T. (Tom) den, Graaf, J.R.A. (Joke) de, Koning, I. (Inge) de, Hammerschlag, M.R., Seelaar, H. (Harro), Seeley, W. (William), Veer, I.M. (Ilya), Buchem, M.A. (Mark) van, Rizzu, P. (Patrizia), and Swieten, J.C. (John) van

Abstract

Objective: We aimed to investigate whether cognitive deficits and structural and functional connectivity changes can be detected before symptom onset in a large cohort of carriers of MAPT (microtubule-associated protein tau) or GRN (progranulin) mutations. Methods: In this case-control study, 75 healthy individuals (aged 20-70 years) with 50% risk of frontotemporal dementia (FTD) underwent DNA screening, neuropsychological assessment, structural MRI, and fMRI. We used voxel-based morphometry and tract-based spatial statistics for voxel-wise analyses of gray matter volume and diffusion tensor imaging measures. Using resting-state fMRI scans, we assessed whole-brain functional connectivity to frontoinsular, anterior midcingulate, and posterior cingulate cortices. Results: Carriers (n = 39) and noncarriers (n = 36) had similar neuropsychological performance, except for lower Letter Digit Substitution Test scores in carriers. Worse performance on Stroop III, Rivermead Behavioral Memory Test, and Happé Cartoons correlated with higher age in carriers, but not controls. Reduced fractional anisotropy in the right uncinate fasciculus was found in carriers compared with controls. Reductions in functional connectivity between anterior midcingulate cortex and frontoinsula and several other brain regions were found in carriers compared with controls and correlated with higher age in carriers, but not controls. We found no significant differences or age correlations in posterior cingulate cortex connectivity. No differences in regional gray matter volume were found, except for a small cluster of higher volume in the precentral gyrus in carriers. Conclusions: This study demonstrates that alterations in structural and functional connectivity develop before the first symptoms of FTD arise. These findings suggest that diffusion tensor imaging and resting-state fMRI may have the potential to become sensitive biomarkers for early FTD in future clinical trials.

Published
2014
Full Text
View/download PDF

39. Structural and functional brain connectivity in presymptomatic familial frontotemporal dementia

Author

Dopper, E.G.P. (Elise), Rombouts, S.A.R.B. (Serge), Jiskoot, L.C. (Lize), Heijer, T. (Tom) den, Graaf, J.R.A. (J. Roos) de, Koning, I. (Inge) de, Hammerschlag, M.R., Seelaar, H. (Harro), Seeley, W. (William), Veer, I.M. (Ilya), Buchem, M.A. (Mark) van, Rizzu, P. (Patrizia), Swieten, J.C. (John) van, Dopper, E.G.P. (Elise), Rombouts, S.A.R.B. (Serge), Jiskoot, L.C. (Lize), Heijer, T. (Tom) den, Graaf, J.R.A. (J. Roos) de, Koning, I. (Inge) de, Hammerschlag, M.R., Seelaar, H. (Harro), Seeley, W. (William), Veer, I.M. (Ilya), Buchem, M.A. (Mark) van, Rizzu, P. (Patrizia), and Swieten, J.C. (John) van

Abstract

Objective: We aimed to investigate whether cognitive deficits and structural and functional connectivity changes can be detected before symptom onset in a large cohort of carriers of microtubuleassociated protein tau and progranulin mutations. Methods: In this case-control study, 75 healthy individuals (aged 20-70 years) with 50%risk for frontotemporal dementia (FTD) underwent DNA screening, neuropsychological assessment, and structural and functional MRI. We used voxel-based morphometry and tract-based spatial statistics for voxelwise analyses of gray matter volume and diffusion tensor imaging measures. Using resting-state fMRI scans, we assessed whole-brain functional connectivity to frontoinsula, anterior midcingulate cortex (aMCC), and posterior cingulate cortex. Results: Although carriers (n 5 37) and noncarriers (n 5 38) had similar neuropsychological performance, worse performance on Stroop III, Ekman faces, and Happé cartoons correlated with higher age in carriers, but not controls. Reduced fractional anisotropy and increased radial diffusivity throughout frontotemporal white matter tracts were found in carriers and correlated with higher age. Reductions in functional aMCC connectivity were found in carriers compared with controls, and connectivity between frontoinsula and aMCC seeds and several brain regions significantly decreased with higher age in carriers but not controls. We found no significant differences or age correlations in posterior cingulate cortex connectivity. No differences in regional gray matter volume were found. Conclusions: This study convincingly demonstrates that alterations in structural and functional connectivity develop before the first symptoms of FTD arise. These findings suggest that diffusion tensor imaging and resting-state fMRI may have the potential to become sensitive biomarkers for early FTD in future clinical trials.

Published
2013
Full Text
View/download PDF

43. Greater male than female variability in regional brain structure across the lifespan

Author

Wierenga, L.M., Doucet, G.E., Dima, D., Agartz, I., Aghajani, M., Akudjedu, T.N., Albajes-Eizagirr, A., Alnæs, D., Alpert, K.I., Andreassen, O.A., Anticevic, A., Asherson, P., Banaschewski, T., Bargallo, N., Baumeister, S., Baur-Streubel, R., Bertolino, A., Bonvino, A., Boomsma, D.I., Borgwardt, S., Bourque, J., den Braber, A., Brandeis, D., Breier, A., Brodaty, H., Brouwer, R.M., Buitelaar, J.K., Busatt, G.F., Calhoun, V.D., Canales-Rodríguez, E.J., Cannon, D.M., Caseras, X., Castellanos, F.X., Chaim-Avancin, T.M., Ching, C.R.K., Clark, V.P., Conrod, P.J., Conzelmann, A., Crivello, F., Davey, C.G., Dickie, E.W., Ehrlich, S., van't Ent, D., Fisher, S.E., Fouche, J.P., Franke, B., Fuentes-Claramonte, P., de Geus, E.J.C, Di Giorgio, A., Glahn, D.C., Gotlib, I.H., Grabe, H.J., Gruber, O., Gruner, P., Gur, R.E., Gur, R.C., Gurholt, T.P., de Haan, L., Haatveit, B., Harrison, B.J., Hartman, C.A., Hatton, S.N., Heslenfeld, D.J., van den Heuvel, O.A., Hickie, I.B., Hoekstra, P.J., Hohmann, S., Holmes, A.J., Hoogman, M., Hosten, N., Howells, F.M., Hulshoff Pol, H.E., Huyser, C., Jahanshad, N., James, A.C., Jiang, J., Jönsson, E.G., Joska, J.A., Kalnin, A.J., Consortium, Karolinska Schizophrenia Project (KaSP), Klein, M., Koenders, L., Kolskår, K.K., Krämer, B., Kuntsi, J., Lagopoulos, J., Lazaro, L., Lebedeva, I.S., Lee, P.H., Lochner, C., Machielsen, M.W.J., Maingault, S., Martin, N.G., Martínez-Zalacaín, I., Mataix-Cols, D., Mazoyer, B., McDonald, B.C., McDonald, C., McIntosh, A.M., McMahon, K.L., McPhilemy, G., van der Meer, D., Menchón, J.M., Naaijen, J., Nyberg, L., Oosterlaan, J., Paloyelis, Y., Pauli, P., Pergola, G., Pomarol-Clotet, E., Portella, M.J., Radua, J., Reif, A., Richards, G., Roffman, J.L., Rosa, P.G.P., Sacchet, M.D., Sachdev, P.S., Salvador, R., Sarró, S., Satterthwaite, T.D., Saykin, A.J., Serpa, M.H., Sim, K., Simmons, A., Smoller, J.W., Sommer, I.E., Soriano-Mas, C., Stein, D.J., Strike, L.T., Szeszko, P.R., Temmingh, H.S., Thomopoulos, S., Tomyshev, A.S., Trollor, J.N., Uhlmann, A., Veer, I.M., Veltman, D.J., Voineskos, A., Völzke, H., Walter, H., Wang, L., Wang, Y., Weber, B., Wen, W., West, J.D., Westlye, L.T., Whalley, H.C., Williams, S.C.R., Wittfeld, K., Wolf, D.H., Wright, M.J., Yoncheva, Y.N., Zanetti, M.V., Ziegler, G.C., de Zubicaray, G.I., Thompson, P.M., Crone, E.A., Frangou, S., Tamnes, C.K., Wierenga, L.M., Doucet, G.E., Dima, D., Agartz, I., Aghajani, M., Akudjedu, T.N., Albajes-Eizagirr, A., Alnæs, D., Alpert, K.I., Andreassen, O.A., Anticevic, A., Asherson, P., Banaschewski, T., Bargallo, N., Baumeister, S., Baur-Streubel, R., Bertolino, A., Bonvino, A., Boomsma, D.I., Borgwardt, S., Bourque, J., den Braber, A., Brandeis, D., Breier, A., Brodaty, H., Brouwer, R.M., Buitelaar, J.K., Busatt, G.F., Calhoun, V.D., Canales-Rodríguez, E.J., Cannon, D.M., Caseras, X., Castellanos, F.X., Chaim-Avancin, T.M., Ching, C.R.K., Clark, V.P., Conrod, P.J., Conzelmann, A., Crivello, F., Davey, C.G., Dickie, E.W., Ehrlich, S., van't Ent, D., Fisher, S.E., Fouche, J.P., Franke, B., Fuentes-Claramonte, P., de Geus, E.J.C, Di Giorgio, A., Glahn, D.C., Gotlib, I.H., Grabe, H.J., Gruber, O., Gruner, P., Gur, R.E., Gur, R.C., Gurholt, T.P., de Haan, L., Haatveit, B., Harrison, B.J., Hartman, C.A., Hatton, S.N., Heslenfeld, D.J., van den Heuvel, O.A., Hickie, I.B., Hoekstra, P.J., Hohmann, S., Holmes, A.J., Hoogman, M., Hosten, N., Howells, F.M., Hulshoff Pol, H.E., Huyser, C., Jahanshad, N., James, A.C., Jiang, J., Jönsson, E.G., Joska, J.A., Kalnin, A.J., Consortium, Karolinska Schizophrenia Project (KaSP), Klein, M., Koenders, L., Kolskår, K.K., Krämer, B., Kuntsi, J., Lagopoulos, J., Lazaro, L., Lebedeva, I.S., Lee, P.H., Lochner, C., Machielsen, M.W.J., Maingault, S., Martin, N.G., Martínez-Zalacaín, I., Mataix-Cols, D., Mazoyer, B., McDonald, B.C., McDonald, C., McIntosh, A.M., McMahon, K.L., McPhilemy, G., van der Meer, D., Menchón, J.M., Naaijen, J., Nyberg, L., Oosterlaan, J., Paloyelis, Y., Pauli, P., Pergola, G., Pomarol-Clotet, E., Portella, M.J., Radua, J., Reif, A., Richards, G., Roffman, J.L., Rosa, P.G.P., Sacchet, M.D., Sachdev, P.S., Salvador, R., Sarró, S., Satterthwaite, T.D., Saykin, A.J., Serpa, M.H., Sim, K., Simmons, A., Smoller, J.W., Sommer, I.E., Soriano-Mas, C., Stein, D.J., Strike, L.T., Szeszko, P.R., Temmingh, H.S., Thomopoulos, S., Tomyshev, A.S., Trollor, J.N., Uhlmann, A., Veer, I.M., Veltman, D.J., Voineskos, A., Völzke, H., Walter, H., Wang, L., Wang, Y., Weber, B., Wen, W., West, J.D., Westlye, L.T., Whalley, H.C., Williams, S.C.R., Wittfeld, K., Wolf, D.H., Wright, M.J., Yoncheva, Y.N., Zanetti, M.V., Ziegler, G.C., de Zubicaray, G.I., Thompson, P.M., Crone, E.A., Frangou, S., and Tamnes, C.K.

Abstract

For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta‐Analysis) Consortium presents the largest‐ever mega‐analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1‐90 years old (47% females). We observed significant patterns of greater male than female between‐subject variance for all subcortical volumetric measures, all cortical surface area measures, and 60% of cortical thickness measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene‐environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex‐specific vulnerability to disorders.

44. Psycho-social factors associated with mental resilience in the Corona lockdown

Author

Veer, Ilya M., Riepenhausen, Antje, Zerban, Matthias, Wackerhagen, Carolin, Puhlmann, Lara M. C., Engen, Haakon, Köber, Göran, Bögemann, Sophie A., Weermeijer, Jeroen, Uściłko, Aleksandra, Mor, Netali, Marciniak, Marta A., Askelund, Adrian Dahl, Al-Kamel, Abbas, Ayash, Sarah, Barsuola, Giulia, Bartkute-Norkuniene, Vaida, Battaglia, Simone, Bobko, Yaryna, Bölte, Sven, Cardone, Paolo, Chvojková, Edita, Damnjanović, Kaja, De Calheiros Velozo, Joana, de Thurah, Lena, Deza-Araujo, Yacila I., Dimitrov, Annika, Farkas, Kinga, Feller, Clémence, Gazea, Mary, Gilan, Donya, Gnjidić, Vedrana, Hajduk, Michal, Hiekkaranta, Anu P., Hofgaard, Live S., Ilen, Laura, Kasanova, Zuzana, Khanpour, Mohsen, Lau, Bobo Hi Po, Lenferink, Dionne B., Lindhardt, Thomas B., Magas, Dávid Á., Mituniewicz, Julian, Moreno-López, Laura, Muzychka, Sofiia, Ntafouli, Maria, O’Leary, Aet, Paparella, Ilenia, Põldver, Nele, Rintala, Aki, Robak, Natalia, Rosická, Anna M., Røysamb, Espen, Sadeghi, Siavash, Schneider, Maude, Siugzdaite, Roma, Stantić, Mirta, Teixeira, Ana, Todorovic, Ana, Wan, Wendy W. N., van Dick, Rolf, Lieb, Klaus, Kleim, Birgit, Hermans, Erno J., Kobylińska, Dorota, Hendler, Talma, Binder, Harald, Myin-Germeys, Inez, van Leeuwen, Judith M. C., Tüscher, Oliver, Yuen, Kenneth S. L., Walter, Henrik, Kalisch, Raffael, Riepenhausen, Antje [0000-0001-8749-5349], Wackerhagen, Carolin [0000-0002-5689-3472], Puhlmann, Lara MC [0000-0002-0870-8770], Marciniak, Marta A [0000-0003-4301-3269], Al-Kamel, Abbas [0000-0002-7941-0381], Ayash, Sarah [0000-0001-5146-1040], Bölte, Sven [0000-0002-4579-4970], Farkas, Kinga [0000-0002-1125-3957], Gnjidić, Vedrana [0000-0002-4036-4525], Hajduk, Michal [0000-0002-7073-7564], Põldver, Nele [0000-0001-7307-544X], van Dick, Rolf [0000-0002-6308-9466], Myin-Germeys, Inez [0000-0002-3731-4930], Tüscher, Oliver [0000-0002-4023-5301], Walter, Henrik [0000-0002-9403-6121], Kalisch, Raffael [0000-0002-9503-7601], Apollo - University of Cambridge Repository, Puhlmann, Lara M. C. [0000-0002-0870-8770], Marciniak, Marta A. [0000-0003-4301-3269], Veer I.M., Riepenhausen A., Zerban M., Wackerhagen C., Puhlmann L.M.C., Engen H., Kober G., Bogemann S.A., Weermeijer J., Uscilko A., Mor N., Marciniak M.A., Askelund A.D., Al-Kamel A., Ayash S., Barsuola G., Bartkute-Norkuniene V., Battaglia S., Bobko Y., Bolte S., Cardone P., Chvojkova E., Damnjanovic K., De Calheiros Velozo J., de Thurah L., Deza-Araujo Y.I., Dimitrov A., Farkas K., Feller C., Gazea M., Gilan D., Gnjidic V., Hajduk M., Hiekkaranta A.P., Hofgaard L.S., Ilen L., Kasanova Z., Khanpour M., Lau B.H.P., Lenferink D.B., Lindhardt T.B., Magas D.A., Mituniewicz J., Moreno-Lopez L., Muzychka S., Ntafouli M., O'Leary A., Paparella I., Poldver N., Rintala A., Robak N., Rosicka A.M., Roysamb E., Sadeghi S., Schneider M., Siugzdaite R., Stantic M., Teixeira A., Todorovic A., Wan W.W.N., van Dick R., Lieb K., Kleim B., Hermans E.J., Kobylinska D., Hendler T., Binder H., Myin-Germeys I., van Leeuwen J.M.C., Tuscher O., Yuen K.S.L., Walter H., Kalisch R., Ontwikkelingspsychologie (Psychologie, FMG), and Psychology Other Research (FMG)

Subjects
Adult, Male, OUTBREAK, Social Sciences, mental health, resilience, pandemic, coronavirus, positive appraisal style, international collaboration, Regression Analysi, lcsh:RC321-571, Cellular and Molecular Neuroscience, Young Adult, 631/477/2811, ddc:150, Human behaviour, 692/53/2421, Disease Transmission, Infectious, Humans, Social Factors, Multivariate Analysi, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Protective Factor, Biological Psychiatry, Cross-Sectional Studie, article, COVID-19, Social Support, Diagnostic markers, Middle Aged, Protective Factors, Resilience, Psychological, ddc:616.8, Europe, Psychiatry and Mental health, Cross-Sectional Studies, Mental Health, Disease Transmission, Infectiou, HEALTH-CARE, Multivariate Analysis, Regression Analysis, Female, Stress, Psychological, Human
Abstract

The SARS-CoV-2 pandemic is not only a threat to physical health but is also having severe impacts on mental health. Although increases in stress-related symptomatology and other adverse psycho-social outcomes, as well as their most important risk factors have been described, hardly anything is known about potential protective factors. Resilience refers to the maintenance of mental health despite adversity. To gain mechanistic insights about the relationship between described psycho-social resilience factors and resilience specifically in the current crisis, we assessed resilience factors, exposure to Corona crisis-specific and general stressors, as well as internalizing symptoms in a cross-sectional online survey conducted in 24 languages during the most intense phase of the lockdown in Europe (22 March to 19 April) in a convenience sample of N = 15,970 adults. Resilience, as an outcome, was conceptualized as good mental health despite stressor exposure and measured as the inverse residual between actual and predicted symptom total score. Preregistered hypotheses (osf.io/r6btn) were tested with multiple regression models and mediation analyses. Results confirmed our primary hypothesis that positive appraisal style (PAS) is positively associated with resilience (p

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results